Detailed information for compound 307770

Basic information

Technical information
  • TDR Targets ID: 307770
  • Name: (E)-N-hydroxy-N-methyl-3-phenanthren-2-ylprop -2-enamide
  • MW: 277.317 | Formula: C18H15NO2
  • H donors: 1 H acceptors: 2 LogP: 3.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(O)C)/C=C/c1ccc2c(c1)ccc1c2cccc1
  • InChi: 1S/C18H15NO2/c1-19(21)18(20)11-7-13-6-10-17-15(12-13)9-8-14-4-2-3-5-16(14)17/h2-12,21H,1H3/b11-7+
  • InChiKey: YYXIRZNCGWVYCR-YRNVUSSQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-N-hydroxy-N-methyl-3-(2-phenanthryl)prop-2-enamide
  • (E)-N-hydroxy-N-methyl-3-(2-phenanthryl)-2-propenamide
  • (E)-N-hydroxy-N-methyl-3-phenanthren-2-yl-prop-2-enamide
  • (E)-N-hydroxy-N-methyl-3-(2-phenanthryl)acrylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major gamma-tubulin 0.021 0.2543 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2543 0.2543
Plasmodium vivax delta tubulin, putative 0.0091 0.1038 0.3757
Entamoeba histolytica tubulin alpha chain, putative 0.021 0.2543 1
Trypanosoma cruzi epsilon tubulin, putative 0.021 0.2543 1
Brugia malayi MAP kinase sur-1 0.005 0.0518 0.1967
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2543 0.2543
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus multilocularis peroxisome assembly protein 26 0.021 0.2543 0.2543
Loa Loa (eye worm) BEN-1 protein 0.021 0.2543 1
Toxoplasma gondii beta-tubulin, putative 0.021 0.2543 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0518 0.1603
Leishmania major alpha tubulin 0.021 0.2543 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0091 0.1038 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0091 0.1038 0.3965
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0192 0.0251
Echinococcus granulosus tubulin subunit beta 0.021 0.2543 0.2995
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0518 0.061
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0013 0.0049 0.0057
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Echinococcus granulosus RUN 0.0024 0.0185 0.0217
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0091 0.1038 0.3757
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Brugia malayi Bromodomain containing protein 0.0038 0.036 0.134
Plasmodium vivax tubulin gamma chain, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Echinococcus granulosus carboxylesterase 5A 0.0078 0.0867 0.1021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0065
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0192 0.145
Loa Loa (eye worm) tubulin beta chain 0.021 0.2543 1
Schistosoma mansoni hypothetical protein 0.0015 0.0073 0.0029
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0103 0.0122
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0192 0.0669
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0119 0.1388 0.5369
Echinococcus multilocularis BC026374 protein (S09 family) 0.0013 0.0049 0.0049
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0518 0.1801
Schistosoma mansoni bromodomain containing protein 0.0064 0.0694 0.0764
Echinococcus multilocularis acetylcholinesterase 0.0078 0.0867 0.0867
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0185 0.0726
Trypanosoma brucei tubulin gamma chain 0.021 0.2543 1
Plasmodium falciparum tubulin gamma chain 0.021 0.2543 1
Schistosoma mansoni zinc finger protein 0.0021 0.0148 0.0118
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Schistosoma mansoni rab6-interacting 0.0024 0.0185 0.0161
Schistosoma mansoni hypothetical protein 0.002 0.014 0.0108
Plasmodium falciparum tubulin delta chain, putative 0.0091 0.1038 0.3757
Leishmania major beta tubulin 0.021 0.2543 1
Plasmodium falciparum tubulin epsilon chain, putative 0.021 0.2543 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0185 0.0217
Giardia lamblia Beta tubulin 0.021 0.2543 1
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Trichomonas vaginalis tubulin epsilon chain, putative 0.0091 0.1038 0.3965
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0331 0.0389
Loa Loa (eye worm) PHD-finger family protein 0.002 0.014 0.0549
Leishmania major beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) BEN-1 protein 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0361 0.142
Leishmania major beta tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0192 0.0251
Entamoeba histolytica tubulin gamma chain 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0726
Entamoeba histolytica tubulin family protein 0.021 0.2543 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0091 0.1038 0.3965
Trypanosoma cruzi beta tubulin, putative 0.021 0.2543 1
Loa Loa (eye worm) carboxylesterase 0.0013 0.0049 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.1038 0.3965
Trichomonas vaginalis tubulin beta chain, putative 0.0119 0.1388 0.5369
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Loa Loa (eye worm) alpha-tubulin 0.021 0.2543 1
Leishmania major alpha tubulin 0.021 0.2543 1
Leishmania major alpha tubulin 0.021 0.2543 1
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0131 0.0236
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0263 0.1033
Brugia malayi Tubulin beta-1 chain 0.021 0.2543 1
Leishmania major alpha tubulin 0.021 0.2543 1
Loa Loa (eye worm) carboxylesterase 0.0078 0.0867 0.3408
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.2543 0.2543
Schistosoma mansoni hypothetical protein 0.0024 0.0185 0.0161
Schistosoma mansoni loxhd1 0.0024 0.0185 0.0161
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Schistosoma mansoni tubulin subunit gamma 0.021 0.2543 0.2954
Brugia malayi CXXC zinc finger family protein 0.003 0.0263 0.0954
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Echinococcus granulosus tubulin alpha 0.021 0.2543 0.2995
Echinococcus multilocularis beta tubulin 0.021 0.2543 0.2543
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0131 0.0517
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Trichomonas vaginalis tubulin gamma chain, putative 0.021 0.2543 1
Echinococcus multilocularis tubulin alpha 0.021 0.2543 0.2543
Toxoplasma gondii alpha-tubulin I, putative 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0867 0.0969
Leishmania major alpha tubulin 0.021 0.2543 1
Trypanosoma cruzi tubulin delta chain 0.0091 0.1038 0.3905
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.1388 0.5457
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Leishmania major alpha tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0192 0.0481
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Onchocerca volvulus 0.0087 0.0984 0.6982
Brugia malayi tubulin alpha chain - mouse 0.021 0.2543 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0091 0.1038 0.3757
Echinococcus granulosus beta tubulin 0.021 0.2543 0.2995
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.8492 0.8492
Onchocerca volvulus 0.0024 0.0185 0.1015
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Loa Loa (eye worm) hypothetical protein 0.0078 0.0867 0.3408
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.158 0.1814
Trichomonas vaginalis tubulin alpha chain, putative 0.0119 0.1388 0.5369
Trypanosoma brucei tubulin delta chain 0.0091 0.1038 0.3905
Mycobacterium ulcerans cell division protein FtsZ 0.0091 0.1038 1
Giardia lamblia Alpha-tubulin 0.021 0.2543 1
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.2543 0.2995
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0095 0.0095
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.158 0.6102
Loa Loa (eye worm) tubulin alpha chain 0.021 0.2543 1
Toxoplasma gondii alpha tubulin TUBA1 0.021 0.2543 1
Brugia malayi Carboxylesterase family protein 0.0078 0.0867 0.335
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0984 0.3814
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2543 0.2995
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0192 0.0251
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0185 0.0185
Brugia malayi Tubulin beta chain 0.0091 0.1038 0.4028
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.2543 0.2995
Brugia malayi Tubulin beta chain 0.0119 0.1388 0.5417
Trichomonas vaginalis tubulin alpha chain, putative 0.0119 0.1388 0.5369
Trypanosoma brucei alpha tubulin, putative 0.0119 0.1388 0.5323
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0192 0.0251
Echinococcus multilocularis neuroligin 0.0013 0.0049 0.0049
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0013 0.0049 0.0049
Trichomonas vaginalis tubulin alpha chain, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0518 0.0518
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0518 0.1801
Echinococcus multilocularis tubulin delta chain 0.0091 0.1038 0.1038
Giardia lamblia Beta tubulin 0.021 0.2543 1
Schistosoma mansoni alpha tubulin 0.021 0.2543 0.2954
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0131 0.0837
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Brugia malayi Tubulin alpha-2 chain 0.021 0.2543 1
Trichomonas vaginalis tubulin, putative 0.0119 0.1388 0.5369
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.1038 0.3965
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0633 0.2078
Loa Loa (eye worm) hypothetical protein 0.0091 0.1038 0.408
Plasmodium vivax tubulin beta chain, putative 0.021 0.2543 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0192 0.145
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.158 0.158
Leishmania major beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) beta-tubulin 0.021 0.2543 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0192 0.0669
Loa Loa (eye worm) hypothetical protein 0.004 0.0391 0.1536
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin epsilon chain 0.021 0.2543 0.2543
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Toxoplasma gondii beta tubulin 0.021 0.2543 1
Entamoeba histolytica tubulin alpha-1 chain 0.021 0.2543 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.158 0.1861
Echinococcus granulosus neuroligin 0.0013 0.0049 0.0057
Onchocerca volvulus 0.0119 0.1388 1
Brugia malayi PHD-finger family protein 0.0026 0.0215 0.0764
Schistosoma mansoni tubulin subunit beta 0.0091 0.1038 0.1171
Echinococcus granulosus dnaJ subfamily B 0.0427 0.5301 0.6242
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2543 0.2995
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0518 0.1801
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0103 0.0103
Schistosoma mansoni zinc finger protein 0.0015 0.0073 0.0029
Echinococcus multilocularis carboxylesterase 5A 0.0078 0.0867 0.0867
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Echinococcus multilocularis tubulin gamma 1 chain 0.021 0.2543 0.2543
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0185 0.0218
Echinococcus multilocularis beta tubulin 0.021 0.2543 0.2543
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0055
Echinococcus granulosus tubulin gamma 1 chain 0.021 0.2543 0.2995
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2543 0.2995
Trypanosoma cruzi zeta tubulin, putative 0.0091 0.1038 0.3905
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.169 0.169
Schistosoma mansoni tubulin subunit alpha 0.0091 0.1038 0.1171
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.2543 0.2995
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0332
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0518 0.2037
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0192 0.0481
Schistosoma mansoni alpha tubulin 0.021 0.2543 0.2954
Loa Loa (eye worm) tubulin alpha chain 0.021 0.2543 1
Echinococcus granulosus tubulin beta 4A class IVa 0.021 0.2543 0.2995
Schistosoma mansoni polycystin 1-related 0.0024 0.0185 0.0161
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Leishmania major beta tubulin 0.021 0.2543 1
Schistosoma mansoni tubulin subunit alpha 0.021 0.2543 0.2954
Loa Loa (eye worm) hypothetical protein 0.0044 0.0436 0.1715
Leishmania major beta tubulin 0.021 0.2543 1
Onchocerca volvulus 0.003 0.0263 0.1599
Loa Loa (eye worm) hypothetical protein 0.021 0.2543 1
Schistosoma mansoni cpg binding protein 0.0034 0.0308 0.0307
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.158 0.6214
Leishmania major beta tubulin 0.021 0.2543 1
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Schistosoma mansoni cpg binding protein 0.003 0.0263 0.0254
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Leishmania major delta tubulin, putative 0.0091 0.1038 0.3905
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Trypanosoma cruzi zeta tubulin, putative 0.0091 0.1038 0.3905
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0131 0.0433
Echinococcus granulosus para nitrobenzyl esterase 0.0013 0.0049 0.0057
Plasmodium vivax tubulin alpha chain, putative 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Giardia lamblia Beta tubulin 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Leishmania major zeta tubulin, putative 0.0091 0.1038 0.3905
Echinococcus multilocularis tubulin subunit TubB 0.021 0.2543 0.2543
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus granulosus microtubule associated protein 2 0.0678 0.8492 1
Brugia malayi Tubulin alpha chain 0.021 0.2543 1
Giardia lamblia Alpha-tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1388 0.5457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0065
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.2543 0.2543
Echinococcus multilocularis acetylcholinesterase 0.0078 0.0867 0.0867
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2543 0.2543
Leishmania major beta tubulin 0.021 0.2543 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0236
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.0865 0.0865
Plasmodium falciparum tubulin beta chain 0.021 0.2543 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0518 0.1801
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0185 0.022
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.5301 0.5301
Brugia malayi hypothetical protein 0.0024 0.0185 0.0643
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0518 0.1801
Toxoplasma gondii beta-1 tubulin, putative 0.021 0.2543 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0103 0.0404
Brugia malayi Tubulin alpha-2 chain 0.021 0.2543 1
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0185 0.022
Echinococcus granulosus cpg binding protein 0.0034 0.0308 0.0363
Schistosoma mansoni hypothetical protein 0.0427 0.5301 0.622
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0689 0.0759
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0331 0.0331
Schistosoma mansoni rab6-interacting 0.0024 0.0185 0.0161
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0095 0.0112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Brugia malayi tubulin alpha-2 chain 0.021 0.2543 1
Brugia malayi hypothetical protein 0.0013 0.0049 0.0104
Trichomonas vaginalis tubulin, putative 0.0119 0.1388 0.5369
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0185 0.0185
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0518 0.1801
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0518 0.061
Echinococcus granulosus BC026374 protein S09 family 0.0013 0.0049 0.0057
Loa Loa (eye worm) tubulin alpha-2 chain 0.021 0.2543 1
Schistosoma mansoni tubulin subunit alpha 0.021 0.2543 0.2954
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Trypanosoma cruzi alpha tubulin, putative 0.021 0.2543 1
Brugia malayi hypothetical protein 0.0024 0.0185 0.0643
Echinococcus granulosus acetylcholinesterase 0.0078 0.0867 0.1021
Loa Loa (eye worm) tubulin beta-1 chain 0.021 0.2543 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0091 0.1038 0.408
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Entamoeba histolytica tubulin family protein 0.021 0.2543 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0185 0.0162
Trichomonas vaginalis tubulin, putative 0.021 0.2543 1
Echinococcus granulosus tubulin epsilon chain 0.021 0.2543 0.2995
Echinococcus granulosus alpha tubulin 0.021 0.2543 0.2995
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0192 0.145
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.021 0.2543 1
Schistosoma mansoni tubulin subunit epsilon 0.021 0.2543 0.2954
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0119 0.1388 0.5457
Trichomonas vaginalis tubulin alpha chain, putative 0.0119 0.1388 0.5369
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0131 0.0236
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0131 0.0131
Echinococcus multilocularis tubulin, beta 4A class IVa 0.021 0.2543 0.2543
Echinococcus multilocularis para nitrobenzyl esterase 0.0013 0.0049 0.0049
Echinococcus granulosus transcription factor Dp 1 0.0077 0.0865 0.1019
Echinococcus granulosus tubulin delta chain 0.0091 0.1038 0.1222
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0518 0.0556
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.2543 0.2995
Leishmania major alpha tubulin 0.021 0.2543 1
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Loa Loa (eye worm) hypothetical protein 0.0087 0.0984 0.3868
Trichomonas vaginalis tubulin alpha chain, putative 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0726
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0131 0.0837
Schistosoma mansoni cpg binding protein 0.0034 0.0308 0.0307
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Brugia malayi Bromodomain containing protein 0.0075 0.084 0.3243
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.1388 0.5457
Echinococcus granulosus tubulin beta 1 chain 0.021 0.2543 0.2995
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0185 0.0185
Leishmania major beta tubulin 0.021 0.2543 1
Trypanosoma brucei zeta tubulin 0.0091 0.1038 0.3905
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.158 0.6102
Trypanosoma cruzi epsilon tubulin, putative 0.021 0.2543 1
Onchocerca volvulus 0.0024 0.0185 0.1015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0518 0.1801
Loa Loa (eye worm) tubulin beta chain 0.0091 0.1038 0.408
Brugia malayi Tubulin gamma chain 0.021 0.2543 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.158 0.6008
Loa Loa (eye worm) tubulin beta-2A chain 0.021 0.2543 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0185 0.0217
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Brugia malayi beta-tubulin, identical 0.021 0.2543 1
Trichomonas vaginalis tubulin gamma chain, putative 0.021 0.2543 1
Trypanosoma brucei protein kinase, putative 0.005 0.0518 0.1801
Brugia malayi Tubulin alpha chain 0.0091 0.1038 0.4028
Loa Loa (eye worm) acetylcholinesterase 1 0.0078 0.0867 0.3408
Entamoeba histolytica hypothetical protein 0.0024 0.0192 0.0251
Brugia malayi Doublecortin family protein 0.0024 0.0185 0.0643
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0055
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0185 0.0217
Mycobacterium tuberculosis Cell division protein FtsZ 0.0091 0.1038 1
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus granulosus peroxisome assembly protein 26 0.021 0.2543 0.2995
Loa Loa (eye worm) alpha-tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin gamma chain, putative 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Trypanosoma brucei zeta tubulin, putative 0.0091 0.1038 0.3905
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Echinococcus multilocularis hypothetical protein 0.021 0.2543 0.2543
Echinococcus granulosus tubulin subunit TubB 0.021 0.2543 0.2995
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0131 0.0155
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0332
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0984 0.1107
Plasmodium falciparum alpha tubulin 1 0.021 0.2543 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0236
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin, putative 0.0091 0.1038 0.3965
Echinococcus multilocularis tubulin subunit beta 0.021 0.2543 0.2543
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Trypanosoma cruzi tubulin delta chain 0.0091 0.1038 0.3905
Trypanosoma cruzi tubulin gamma chain 0.021 0.2543 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Echinococcus granulosus beta tubulin 0.021 0.2543 0.2995
Loa Loa (eye worm) tubulin gamma chain 0.021 0.2543 1
Loa Loa (eye worm) tubulin beta-4 chain 0.021 0.2543 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.169 0.199
Schistosoma mansoni tubulin subunit delta 0.0091 0.1038 0.1171
Echinococcus multilocularis cpg binding protein 0.0034 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.007 0.0765 0.3007
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus granulosus acetylcholinesterase 0.0078 0.0867 0.1021
Mycobacterium leprae cell division protein FtsZ 0.0091 0.1038 1
Echinococcus multilocularis RUN 0.0024 0.0185 0.0185
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0764
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Giardia lamblia Delta tubulin 0.0091 0.1038 0.3757
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0518 0.0518
Leishmania major beta tubulin 0.021 0.2543 1
Schistosoma mansoni lipoxygenase 0.01 0.1146 0.13
Loa Loa (eye worm) carboxylesterase 0.0013 0.0049 0.0191
Giardia lamblia Gamma tubulin 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0407
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.2543 0.2543
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0649
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.158 0.6102
Leishmania major epsilon tubulin, putative 0.021 0.2543 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0518 0.1603
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0119 0.1388 0.5369
Plasmodium vivax tubulin alpha chain, putative 0.021 0.2543 1
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Schistosoma mansoni alpha tubulin 0.021 0.2543 0.2954
Plasmodium vivax tubulin epsilon chain, putative 0.021 0.2543 1
Treponema pallidum cell division protein FtsZ 0.0091 0.1038 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.158 0.6181
Trypanosoma brucei epsilon tubulin 0.021 0.2543 1
Echinococcus granulosus zinc finger protein 0.0021 0.0148 0.0175
Schistosoma mansoni lipoxygenase 0.0142 0.169 0.1944
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0192 0.5
Trypanosoma brucei epsilon tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0091 0.1038 0.3965
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.158 0.6102
Echinococcus multilocularis tubulin beta 1 chain 0.021 0.2543 0.2543
Brugia malayi Carboxylesterase family protein 0.0078 0.0867 0.335
Giardia lamblia Epsilon tubulin 0.0091 0.1038 0.3757
Trypanosoma brucei epsilon tubulin 0.021 0.2543 1
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.8492 1
Leishmania major alpha tubulin 0.021 0.2543 1
Plasmodium falciparum alpha tubulin 2 0.021 0.2543 1
Brugia malayi alpha-tubulin 0.021 0.2543 1
Brugia malayi Cell division protein ftsZ 0.0091 0.1038 0.4028
Echinococcus multilocularis zinc finger protein 0.0021 0.0148 0.0148
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.2543 0.2543
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0078 0.0867 0.3408
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0984 0.1158
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0098
Schistosoma mansoni tubulin subunit alpha 0.021 0.2543 0.2954

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.82 Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) ChEMBL. 2308149
IC50 (binding) = 0.13 uM In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) ChEMBL. 2308149
IC50 (binding) = 0.13 uM In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) ChEMBL. 2308149
Log 1/IC50 (binding) = 5.82 Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) ChEMBL. 2308149

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.