Detailed information for compound 337805

Basic information

Technical information
  • TDR Targets ID: 337805
  • Name: AIDS-292469
  • MW: 344.36 | Formula: C17H13FN2O3S
  • H donors: 0 H acceptors: 2 LogP: 3.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S/C(=N/c1ccccc1F)/OCCN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C17H13FN2O3S/c18-13-7-3-4-8-14(13)19-17(24)23-10-9-20-15(21)11-5-1-2-6-12(11)16(20)22/h1-8H,9-10H2,(H,19,24)
  • InChiKey: XGBLJXFOOFNXQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS292469
  • Carbamothioic acid, (2-fluorophenyl)-, O-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl] ester
  • N-(2-fluorophenyl)carbamothioic acid O-[2-(1,3-dioxo-2-isoindolinyl)ethyl] ester
  • N-(2-fluorophenyl)thiocarbamic acid O-(2-phthalimidoethyl) ester
  • O-[2-(1,3-dioxoisoindol-2-yl)ethyl] N-(2-fluorophenyl)carbamothioate
  • O-[2-(1,3-dioxoisoindolin-2-yl)ethyl] N-(2-fluorophenyl)carbamothioate
  • O-[2-(1,3-dioxoisoindol-2-yl)ethyl] [(2-fluorophenyl)amino]methanethioate
  • O-[2-(1,3-dioxoisoindolin-2-yl)ethyl] [(2-fluorophenyl)amino]methanethioate
  • [(2-fluorophenyl)amino]methanethioic acid O-[2-(1,3-dioxo-2-isoindolinyl)ethyl] ester
  • [(2-fluorophenyl)amino]methanethioic acid O-[2-(1,3-diketoisoindolin-2-yl)ethyl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Neuropeptide F receptor homolog 0.0121 0.1409 0.6573
Schistosoma mansoni amine GPCR 0.0121 0.1409 0.3447
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0121 0.1409 0.3447
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0363 0.0428
Brugia malayi Dopamine receptor 0.0121 0.1409 0.6581
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.0267 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.0267 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Loa Loa (eye worm) solute carrier family 6 member 4 0.0178 0.2141 0.3257
Schistosoma mansoni hypothetical protein 0.0051 0.0528 0.129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Brugia malayi topoisomerase 0.001 0.0006 0.0026
Echinococcus granulosus tyrosine kinase 0.0034 0.0317 0.0317
Schistosoma mansoni topbp1 0.001 0.0006 0.0013
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0264
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0267 0.0653
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Onchocerca volvulus 0.0121 0.1409 0.6573
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0104 0.029
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0317 0.0317
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.001 0.0015 0.0029
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0121 0.1409 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.001 0.0015 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0179 0.0481
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0121 0.1409 0.1663
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus multilocularis g protein coupled receptor 0.0121 0.1409 0.1663
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0287 0.1926
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0121 0.1409 0.6581
Echinococcus multilocularis G-protein coupled receptor, putative 0.0121 0.1409 0.1663
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.0267 0.0653
Echinococcus multilocularis expressed protein 0.0033 0.0297 0.035
Onchocerca volvulus 0.003 0.0267 0.1224
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0121 0.1409 0.1663
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0041
Trichomonas vaginalis rotamase, putative 0.0033 0.0297 0.7125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0287 0.313
Brugia malayi Tachykinin-like peptides receptor 99D 0.0121 0.1409 0.6581
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0363 0.0363
Brugia malayi Cytochrome P450 family protein 0.001 0.0015 0.0072
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.1451 1
Echinococcus granulosus serotonin receptor 0.0121 0.1409 0.1409
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0279 0.3413 1
Brugia malayi Furin-like cysteine rich region family protein 0.0148 0.1754 0.8189
Onchocerca volvulus 0.0121 0.1409 0.6573
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Onchocerca volvulus 0.0121 0.1409 0.6573
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0179 0.0509
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0021
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0121 0.1409 0.1663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0041
Onchocerca volvulus 0.0121 0.1409 0.6573
Echinococcus granulosus G protein coupled receptor 139 0.0121 0.1409 0.1409
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0104 0.0262
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.001 0.0015 0.0029
Brugia malayi steroid hormone receptor 0.001 0.0009 0.0041
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.001 0.0015 0.0029
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0015 0.0068
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0121 0.1409 0.1409
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0369 0.0369
Leishmania major cytochrome p450-like protein 0.001 0.0015 0.0042
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.0151
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.037 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0009 0.0021
Onchocerca volvulus 0.0121 0.1409 0.6573
Loa Loa (eye worm) acetyltransferase 0.0143 0.1688 0.2566
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0267 0.0653
Echinococcus multilocularis orexin receptor type 2 0.0121 0.1409 0.1663
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.001 0.0015 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0121 0.1409 0.1663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.1451 0.1713
Echinococcus granulosus 7tm_1 domain containing protein 0.0121 0.1409 0.1409
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Brugia malayi Protein kinase domain containing protein 0.0048 0.049 0.2289
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Leishmania major basic transcription factor 3a, putative 0.0034 0.0316 0.2127
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Echinococcus granulosus neuropeptide FF receptor 2 0.0121 0.1409 0.1409
Echinococcus granulosus somatostatin receptor 0.0121 0.1409 0.1409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0009 0.0027
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0121 0.1409 0.1409
Echinococcus granulosus transcription factor btf3 0.0034 0.0316 0.0316
Echinococcus granulosus epidermal growth factor receptor 0.008 0.0894 0.0894
Schistosoma mansoni amine GPCR 0.0121 0.1409 0.3447
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0316 0.7598
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0121 0.1409 0.3447
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0038
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0363 0.0428
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0092 0.0226
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0009
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.0178 0.2141 0.3257
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0279 0.3413 1
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.1754 0.1754
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.0267 0.1247
Loa Loa (eye worm) melatonin receptor type 1A 0.0121 0.1409 0.2141
Echinococcus multilocularis allatostatin A receptor 0.0121 0.1409 0.1663
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0363 0.0363
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.008 0.0894 0.0894
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0121 0.1409 0.1663
Echinococcus granulosus neuropeptides capa receptor 0.0121 0.1409 0.1409
Loa Loa (eye worm) serotonin transporter b 0.0178 0.2141 0.3257
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.6395
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.001 0.0015 0.0029
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0316 0.0912
Echinococcus granulosus orexin receptor type 2 0.0121 0.1409 0.1409
Onchocerca volvulus 0.0121 0.1409 0.6573
Schistosoma mansoni biogenic amine receptor 0.0121 0.1409 0.3447
Brugia malayi protein-tyrosine kinase 0.0034 0.0317 0.1482
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0124 0.1451 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0009 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0009 0.0015
Echinococcus granulosus neuropeptide Y receptor 0.0121 0.1409 0.1409
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.0267 0.0267
Brugia malayi Cytochrome P450 family protein 0.001 0.0015 0.0072
Echinococcus multilocularis insulin receptor 0.0048 0.049 0.0578
Loa Loa (eye worm) norepinephrine transporter 0.0178 0.2141 0.3257
Echinococcus multilocularis neuropeptide Y receptor 0.0121 0.1409 0.1663
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.001 0.0015 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Echinococcus multilocularis somatostatin receptor 0.0121 0.1409 0.1663
Leishmania major cytochrome p450-like protein 0.001 0.0015 0.0042
Leishmania major lanosterol 14-alpha-demethylase, putative 0.001 0.0015 0.0042
Schistosoma mansoni amine GPCR 0.0121 0.1409 0.3447
Brugia malayi Melatonin receptor type 1A 0.0121 0.1409 0.6581
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Schistosoma mansoni transcription factor btf3 0.0034 0.0316 0.0773
Brugia malayi SRC-1 0.0038 0.0363 0.1695
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0121 0.1409 0.1663
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0015 0.0015
Onchocerca volvulus 0.0121 0.1409 0.6573
Schistosoma mansoni neuropeptide receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus multilocularis 0.0045 0.0458 0.0541
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0121 0.1409 0.3447
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1638 0.1638
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0121 0.1409 0.2141
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0363 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.1451 0.1713
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Loa Loa (eye worm) TK protein kinase 0.0034 0.0317 0.0475
Schistosoma mansoni adenoreceptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Brugia malayi hypothetical protein 0.001 0.0006 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0179 0.1176
Onchocerca volvulus 0.0121 0.1409 0.6573
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni hypothetical protein 0.0332 0.4089 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0363 0.0428
Schistosoma mansoni cytochrome P450 0.001 0.0015 0.0038
Plasmodium falciparum transporter, putative 0.003 0.0267 0.0767
Trichomonas vaginalis rotamase, putative 0.0032 0.0287 0.6887
Onchocerca volvulus 0.0121 0.1409 0.6573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Echinococcus granulosus insulin receptor 0.0048 0.049 0.049
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0121 0.1409 0.2141
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0015 0.024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.0151
Echinococcus granulosus geminin 0.0332 0.4089 0.4089
Schistosoma mansoni neuropeptide F-like receptor 0.0121 0.1409 0.3447
Echinococcus granulosus g protein coupled receptor 0.0121 0.1409 0.1409
Echinococcus granulosus fmrfamide receptor 0.0121 0.1409 0.1409
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.001 0.0015 0.0029
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0267 0.0653
Schistosoma mansoni tyrosine kinase 0.008 0.0894 0.2188
Echinococcus granulosus allatostatin A receptor 0.0121 0.1409 0.1409
Echinococcus granulosus neuropeptide receptor 0.0121 0.1409 0.1409
Brugia malayi AKH receptor 0.0121 0.1409 0.6581
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0414 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0179 0.0836
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0121 0.1409 0.2141
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0316 0.3453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.027 0.027
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0294 0.0294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.1409 0.3447
Schistosoma mansoni neuropeptide receptor 0.0121 0.1409 0.3447
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0316 0.2148
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0414 0.0414
Schistosoma mansoni rotamase 0.0033 0.0297 0.0726
Schistosoma mansoni tyrosine kinase 0.0048 0.049 0.1199
Echinococcus granulosus tm gpcr rhodopsin 0.0121 0.1409 0.1409
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.001
Brugia malayi Dopamine receptor protein 2 0.0121 0.1409 0.6581
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0121 0.1409 0.1663
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Schistosoma mansoni opsin-like receptor 0.0121 0.1409 0.3447
Schistosoma mansoni nuclear hormone receptor 0.001 0.0009 0.0021
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0528 0.6564 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.001 0.0015 0.0029
Brugia malayi hypothetical protein 0.003 0.0267 0.1247
Schistosoma mansoni DNA ligase IV 0.001 0.0006 0.0013
Schistosoma mansoni hypothetical protein 0.0332 0.4089 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0317 0.0374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0092 0.0226
Schistosoma mansoni hypothetical protein 0.0121 0.1409 0.3447
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0121 0.1409 0.1663
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0267 0.0267
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.001 0.0015 0.0029
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0121 0.1409 0.1409
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0179 0.0509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1688 0.1992
Mycobacterium ulcerans hypothetical protein 0.0023 0.0179 0.0509
Echinococcus multilocularis serotonin receptor 0.0121 0.1409 0.1663
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.0399
Echinococcus granulosus sex peptide receptor 0.0121 0.1409 0.1409
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.1247
Echinococcus granulosus g protein coupled receptor 0.0121 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0121 0.1409 0.1663
Schistosoma mansoni tyrosine kinase 0.008 0.0894 0.2188
Echinococcus multilocularis neuropeptide Y receptor 0.0121 0.1409 0.1663
Echinococcus multilocularis g protein coupled receptor 0.0121 0.1409 0.1663
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0363 0.0363
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0279 0.3413 1
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0414 0.12
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0005
Schistosoma mansoni myosin xvIII 0.0121 0.1409 0.3447
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0487 0.0735
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Brugia malayi putative neuropeptide receptor NPR1 0.0121 0.1409 0.6581
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0179 0.0509
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0267 0.0315
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0009 0.0015
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0363 0.0428
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.1451 0.1713
Echinococcus multilocularis neuropeptide receptor 0.0121 0.1409 0.1663
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0414 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0121 0.1409 0.1663
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0121 0.1409 0.3447
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Brugia malayi neuropeptide F receptor 0.0121 0.1409 0.6581
Onchocerca volvulus 0.003 0.0267 0.1224
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0104 0.3778
Entamoeba histolytica protein kinase, putative 0.0031 0.027 0.2945
Trypanosoma brucei cytochrome P450, putative 0.001 0.0015 0.0068
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0121 0.1409 0.6581
Echinococcus granulosus expressed protein 0.0033 0.0297 0.0297
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0015 0.0068
Entamoeba histolytica hypothetical protein 0.0034 0.0316 0.3453
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Schistosoma mansoni biogenic amine receptor 0.0121 0.1409 0.3447
Echinococcus granulosus tm gpcr rhodopsin 0.0121 0.1409 0.1409
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0005
Echinococcus granulosus replication factor c subunit 1 0.001 0.0006 0.0006
Brugia malayi hypothetical protein 0.001 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus multilocularis G protein coupled receptor 139 0.0121 0.1409 0.1663
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0121 0.1409 0.6581
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0041
Brugia malayi Cytochrome P450 family protein 0.0048 0.0487 0.2276
Loa Loa (eye worm) CYP4Cod1 0.001 0.0015 0.0015
Brugia malayi RE15519p 0.0121 0.1409 0.6581
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0267 0.0267
Onchocerca volvulus 0.0121 0.1409 0.6573
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0092 0.0226
Echinococcus granulosus peptide allatostatin:somatostatin 0.0121 0.1409 0.1409
Onchocerca volvulus 0.003 0.0267 0.1224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0316 0.7598
Loa Loa (eye worm) TK protein kinase 0.0031 0.027 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0005
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0006 0.0026
Brugia malayi nuclear hormone receptor 0.001 0.0009 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0021
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.001 0.0015 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0009 0.0041
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0363 0.0428
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0121 0.1409 0.1663
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0179 0.1176
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.0151
Schistosoma mansoni coup transcription factor 0.001 0.0009 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0121 0.1409 0.3447
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.001 0.0015 0.0029
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0121 0.1409 0.3447
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0009 0.0094
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1688 0.4129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0092 0.0226
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0905 1
Plasmodium vivax amine transporter, putative 0.003 0.0267 0.0767
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0104 0.029
Brugia malayi Serotonin receptor 0.0121 0.1409 0.6581
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.0151
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0316 0.0474
Echinococcus granulosus biogenic amine 5HT receptor 0.0121 0.1409 0.1409
Onchocerca volvulus 0.0121 0.1409 0.6573
Onchocerca volvulus 0.0121 0.1409 0.6573
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.0151
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.001
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.001 0.0015 0.0029
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0316 0.2148
Loa Loa (eye worm) G-protein coupled receptor 0.0121 0.1409 0.2141
Brugia malayi nuclear receptor NHR-88 0.001 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0009 0.0021
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0273 0.0667
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.1247
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0179 0.0509
Onchocerca volvulus 0.0121 0.1409 0.6573
Echinococcus multilocularis geminin 0.0332 0.4089 0.4825
Loa Loa (eye worm) hypothetical protein 0.0178 0.2141 0.3257
Echinococcus granulosus neuropeptides capa receptor 0.0121 0.1409 0.1409
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.6395
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0124 0.1451 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0121 0.1409 0.3447
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Echinococcus granulosus tm gpcr rhodopsin 0.063 0.7852 0.7852
Schistosoma mansoni opsin-like receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0121 0.1409 0.1663
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0179 0.0509
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0316 0.7598
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0015 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus granulosus mitogen activated protein kinase 11 0.0124 0.1451 0.1451
Brugia malayi DKFZp564C0469 protein 0.001 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0015 0.0068
Brugia malayi sulfakinin receptor protein 0.0121 0.1409 0.6581
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0294 0.0346
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Brugia malayi Serotonin receptor 0.0121 0.1409 0.6581
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.1247
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0267 0.0653
Treponema pallidum hypothetical protein 0.0279 0.3413 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0124 0.1451 0.1451
Echinococcus multilocularis 0.001 0.0015 0.0018
Brugia malayi neuropeptide F receptor 0.0121 0.1409 0.6581
Toxoplasma gondii hypothetical protein 0.003 0.0267 0.6395
Onchocerca volvulus 0.0023 0.0179 0.0812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Leishmania major cytochrome p450-like protein 0.001 0.0015 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0179 0.0836
Echinococcus multilocularis g-protein coupled receptor 0.0121 0.1409 0.1663
Brugia malayi larval opioid receptor 0.0121 0.1409 0.6581
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0041
Loa Loa (eye worm) neuropeptide F receptor 0.0121 0.1409 0.2141
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0009 0.0015
Plasmodium vivax hypothetical protein, conserved 0.003 0.0267 0.0767
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.1409 0.3447
Echinococcus granulosus dro:myosuppressin receptor 0.0121 0.1409 0.1409
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Brugia malayi G protein-coupled receptor 0.0121 0.1409 0.6581
Echinococcus granulosus g protein coupled receptor 0.0121 0.1409 0.1409
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.1451 0.1713
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.063 0.7852 0.9266
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0006 0.0013
Schistosoma mansoni histamine h1 receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0528 0.6564 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0414 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.001 0.0015 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0121 0.1409 0.3447
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.001 0.0015 0.0029
Schistosoma mansoni neuropeptide f receptor 76f 0.0121 0.1409 0.3447
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0317 0.0317
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0363 0.0428
Echinococcus multilocularis neuropeptide s receptor 0.0121 0.1409 0.1663
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0264
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0009 0.0021
Schistosoma mansoni topbp1 0.001 0.0006 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0179 0.1176
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0279 0.3413 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0287 0.1947
Brugia malayi Cytochrome P450 family protein 0.001 0.0015 0.0072
Onchocerca volvulus 0.0178 0.2141 1
Mycobacterium leprae putative cytochrome p450 0.001 0.0015 0.0029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0121 0.1409 0.6573
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0363 0.0363
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0179 0.0836
Onchocerca volvulus 0.001 0.0009 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.037 0.4053
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0121 0.1409 0.1409
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0316 0.7598
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0009 0.0021
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0363 0.0428
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0178 0.2141 0.5237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Brugia malayi ecdysteroid receptor 0.001 0.0009 0.0041
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.0267 0.0315
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0048 0.049 0.1199
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0317 0.0374
Echinococcus granulosus neuropeptide s receptor 0.0121 0.1409 0.1409
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0121 0.1409 0.1409
Echinococcus multilocularis epidermal growth factor receptor 0.008 0.0894 0.1055
Loa Loa (eye worm) TYRA-2 protein 0.0121 0.1409 0.2141
Brugia malayi P38 map kinase family protein 2 0.0124 0.1451 0.6778
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0041
Echinococcus multilocularis neuropeptide FF receptor 2 0.0121 0.1409 0.1663
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0005
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0316 0.0912
Brugia malayi G-protein coupled receptor 0.0121 0.1409 0.6581
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.049 0.0578
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0121 0.1409 0.1409
Brugia malayi beta-NAC-like protein 0.0034 0.0316 0.1476
Brugia malayi follicle stimulating hormone receptor 0.0121 0.1409 0.6581
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0178 0.2141 0.3257
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.001 0.0015 0.0029
Echinococcus granulosus g-protein coupled receptor 0.0121 0.1409 0.1409
Schistosoma mansoni amine GPCR 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0399
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Echinococcus multilocularis fmrfamide receptor 0.0121 0.1409 0.1663
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0009 0.0041
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.049 0.049
Schistosoma mansoni neuropeptide F-like receptor 0.0121 0.1409 0.3447
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0287 0.1947
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.0399
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0009 0.0021
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.027 0.0319
Echinococcus multilocularis dro:myosuppressin receptor 0.0121 0.1409 0.1663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0005
Brugia malayi Dopamine receptor protein 1 0.0121 0.1409 0.6581
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0179 0.1927
Schistosoma mansoni tyrosine kinase 0.0038 0.0363 0.0888
Echinococcus granulosus neuropeptide receptor A26 0.0121 0.1409 0.1409
Schistosoma mansoni neuropeptide receptor 0.0121 0.1409 0.3447
Schistosoma mansoni biogenic amine (5HT) receptor 0.0121 0.1409 0.3447
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0267 0.0653
Brugia malayi ORL1-like opioid receptor 0.0121 0.1409 0.6581
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0009 1
Onchocerca volvulus 0.0121 0.1409 0.6573
Schistosoma mansoni tyrosine kinase 0.0038 0.0363 0.0888
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0267 0.0653
Schistosoma mansoni biogenic amine (5HT) receptor 0.0121 0.1409 0.3447
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus granulosus biogenic amine 5HT receptor 0.0121 0.1409 0.1409
Schistosoma mansoni tyrosine kinase 0.0078 0.0871 0.213
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus multilocularis nibrin 0.001 0.0006 0.0007
Schistosoma mansoni neuropeptide receptor 0.0121 0.1409 0.3447
Schistosoma mansoni alpha-1 adrenergic receptor 0.0121 0.1409 0.3447
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0267 0.0315
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0179 0.0509
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0905 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0015 0.0068
Echinococcus granulosus serotonin transporter 0.0178 0.2141 0.2141
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0297 0.1386
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0009 0.0027
Echinococcus multilocularis transcription factor btf3 0.0034 0.0316 0.0373
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0414 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0267 0.0653
Loa Loa (eye worm) hypothetical protein 0.0081 0.0905 0.1372
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0121 0.1409 0.6581
Echinococcus granulosus neuropeptide Y receptor 0.0121 0.1409 0.1409
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0363 0.0428
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0121 0.1409 0.6581
Echinococcus multilocularis serotonin transporter 0.0178 0.2141 0.2527
Schistosoma mansoni tyrosine kinase 0.0078 0.0871 0.213
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0124 0.1451 0.2205
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0279 0.3413 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0121 0.1409 0.2141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.1409 0.3447
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0179 0.0509
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Onchocerca volvulus 0.0121 0.1409 0.6573
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Schistosoma mansoni hypothetical protein 0.0121 0.1409 0.3447
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0363 0.0363
Brugia malayi putative neuropeptide receptor 0.0121 0.1409 0.6581
Echinococcus granulosus 7TM GPCR rhodopsin 0.0121 0.1409 0.1409
Schistosoma mansoni sodium/chloride dependent transporter 0.0178 0.2141 0.5237
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0121 0.1409 0.1663
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0015 0.0015
Brugia malayi G-protein coupled receptor 0.0121 0.1409 0.6581
Schistosoma mansoni tyrosine kinase 0.0078 0.0871 0.213
Onchocerca volvulus 0.0121 0.1409 0.6573
Loa Loa (eye worm) G-protein coupled receptor 0.0121 0.1409 0.2141
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.037 0.107
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.049 0.0739
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.001
Echinococcus multilocularis neuropeptide receptor 0.0121 0.1409 0.1663
Brugia malayi cytochrome P450 0.001 0.0015 0.0072
Echinococcus multilocularis fmrfamide receptor 0.0121 0.1409 0.1663
Echinococcus granulosus alpha 1A adrenergic receptor 0.0121 0.1409 0.1409
Schistosoma mansoni hypothetical protein 0.0121 0.1409 0.3447
Echinococcus multilocularis neuropeptides capa receptor 0.0121 0.1409 0.1663
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0267 0.0653
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.001 0.0015 0.0029
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0267 0.0267
Schistosoma mansoni amine GPCR 0.0121 0.1409 0.3447
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1688 0.7883
Schistosoma mansoni tyrosine kinase 0.0148 0.1754 0.4289
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0179 0.0509
Echinococcus multilocularis sex peptide receptor 0.0121 0.1409 0.1663
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0104 0.029
Plasmodium falciparum amino acid transporter, putative 0.003 0.0267 0.0767
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0179 0.1927
Brugia malayi GnHR receptor homolog 0.0121 0.1409 0.6581
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) cytochrome P450 0.001 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0317 0.0374
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.1409 0.1663
Brugia malayi hypothetical protein 0.0121 0.1409 0.6581
Mycobacterium leprae Conserved hypothetical protein 0.001 0.0015 0.0029
Echinococcus multilocularis serotonin receptor 0.0121 0.1409 0.1663
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0121 0.1409 0.1663
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0267 0.0267
Treponema pallidum sodium- and chloride- dependent transporter 0.0178 0.2141 0.6268
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0005
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0179 0.0481
Loa Loa (eye worm) SRC-1 0.0038 0.0363 0.0545
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0005
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0297 0.0444
Toxoplasma gondii hypothetical protein 0.003 0.0267 0.6395
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0178 0.2141 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0179 0.0509
Onchocerca volvulus 0.0121 0.1409 0.6573
Brugia malayi G protein-coupled receptor F59B2.13 0.0121 0.1409 0.6581
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0041
Schistosoma mansoni hypothetical protein 0.0121 0.1409 0.3447
Loa Loa (eye worm) TK/EGFR protein kinase 0.0148 0.1754 0.2665
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0015 0.0068
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.001 0.0015 0.0029
Echinococcus multilocularis conserved hypothetical protein 0.0679 0.8474 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.001 0.0015 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus granulosus tachykinin peptides receptor 99D 0.0121 0.1409 0.1409
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0267 0.0653
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0264
Schistosoma mansoni biogenic amine receptor 0.0121 0.1409 0.3447
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0316 0.2148
Loa Loa (eye worm) neuropeptide F receptor 0.0121 0.1409 0.2141
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.0267 0.0315
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0179 0.1927
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0006 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0267 0.6395
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0121 0.1409 0.1663
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.1754 0.2069
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.001 0.0015 0.0029
Echinococcus granulosus neuropeptide receptor 0.0121 0.1409 0.1409
Schistosoma mansoni opsin-like receptor 0.0121 0.1409 0.3447
Echinococcus granulosus nibrin 0.001 0.0006 0.0006
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Loa Loa (eye worm) hypothetical protein 0.0121 0.1409 0.2141
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0297 0.7125
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.1451 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.001 0.0015 0.0029
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0287 0.6887
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0287 0.1947

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 100 uM Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method ChEMBL. 15916438
CC50 (functional) > 100 uM Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method ChEMBL. 15916438
EC50 (functional) = 3 uM Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method ChEMBL. 15916438
EC50 (functional) = 3 uM Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method ChEMBL. 15916438
SI (functional) > 33 Ratio of CC50 to that of EC50 determined in MT-4 cells ChEMBL. 15916438

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15916438

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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