Detailed information for compound 340552

Basic information

Technical information
  • TDR Targets ID: 340552
  • Name: 1-[(4-tert-butylphenyl)methyl]-3-[[3-cyano-4- (methanesulfonamido)phenyl]methyl]thiourea
  • MW: 430.587 | Formula: C21H26N4O2S2
  • H donors: 2 H acceptors: 3 LogP: 4.3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc(CN/C(=N/Cc2ccc(cc2)C(C)(C)C)/S)ccc1NS(=O)(=O)C
  • InChi: 1S/C21H26N4O2S2/c1-21(2,3)18-8-5-15(6-9-18)13-23-20(28)24-14-16-7-10-19(17(11-16)12-22)25-29(4,26)27/h5-11,25H,13-14H2,1-4H3,(H2,23,24,28)
  • InChiKey: YXWMNXXIQMALNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-tert-butylphenyl)methyl]-3-[[3-cyano-4-(methylsulfonylamino)phenyl]methyl]thiourea
  • 1-(4-tert-butylbenzyl)-3-[3-cyano-4-(methanesulfonamido)benzyl]thiourea
  • 1-[(4-tert-butylphenyl)methyl]-3-[(3-cyano-4-methanesulfonamidophenyl)methyl]thiourea
  • 1-[(4-tert-butylphenyl)methyl]-3-[(3-cyano-4-methanesulfonamido-phenyl)methyl]thiourea
  • 1-(4-tert-butylbenzyl)-3-(3-cyano-4-methanesulfonamido-benzyl)thiourea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Vanilloid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0982 0.7814 0.8114
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0145
Schistosoma mansoni lipoxygenase 0.0021 0.0038 0.004
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0136 0.0494
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0982 0.7814 0.7814
Loa Loa (eye worm) neuropeptide F receptor 0.0982 0.7814 0.7814
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0205 0.0212
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.028 0.2134 0.2134
Onchocerca volvulus 0.0982 0.7814 0.956
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0135 0.0135
Schistosoma mansoni myosin xvIII 0.0982 0.7814 0.8114
Schistosoma mansoni neuropeptide receptor 0.0982 0.7814 0.8114
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0982 0.7814 0.8114
Echinococcus granulosus lamin 0.0061 0.0364 0.0378
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0046 0.0046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0916 0.0951
Echinococcus multilocularis adenylate cyclase 9 0.0092 0.0618 0.0641
Echinococcus multilocularis neuropeptide Y receptor 0.0982 0.7814 0.8114
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0053 0.0162
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi Protein kinase domain containing protein 0.0017 0.0005 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1101 0.3391
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0982 0.7814 0.8114
Echinococcus granulosus alpha 1A adrenergic receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0827 0.0858
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Loa Loa (eye worm) G-protein coupled receptor 0.0982 0.7814 0.7814
Echinococcus multilocularis snurportin 1 0.0309 0.2366 0.2457
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0388 0.0402
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0135 0.0488
Echinococcus multilocularis G-protein coupled receptor, putative 0.0982 0.7814 0.8114
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0323 0.0993
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0205 0.063
Echinococcus multilocularis neuropeptide receptor 0.0982 0.7814 0.8114
Brugia malayi Melatonin receptor type 1A 0.0982 0.7814 0.7814
Leishmania major hypothetical protein, conserved 0.0056 0.0323 0.0993
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0053 0.0162
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0982 0.7814 0.8114
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0213 0.1346
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.0042
Echinococcus granulosus serotonin receptor 0.0982 0.7814 0.8114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.006 0.0046
Trichomonas vaginalis set domain proteins, putative 0.1026 0.8168 1
Schistosoma mansoni opsin-like receptor 0.0982 0.7814 0.8114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0721 0.0721
Brugia malayi Cytochrome P450 family protein 0.0023 0.0053 0.0053
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0135 0.0417
Onchocerca volvulus 0.0022 0.0046 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.2134 0.2216
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0828 0.2548
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Schistosoma mansoni polycystin 1-related 0.0021 0.0038 0.004
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0828 0.0828
Echinococcus granulosus RUN 0.0021 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0164 0.0171
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0452 0.0452
Echinococcus granulosus 7tm_1 domain containing protein 0.0982 0.7814 0.8114
Echinococcus multilocularis geminin 0.037 0.2864 0.2974
Schistosoma mansoni biogenic amine (5HT) receptor 0.0982 0.7814 0.8114
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0053 0.0162
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0145
Brugia malayi G protein-coupled receptor 0.0982 0.7814 0.7814
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0323 0.0993
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0125 0.0878 0.0911
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0046 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0068 0.021
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0135 0.0141
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0506 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0205 0.063
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Brugia malayi hypothetical protein 0.0021 0.0038 0.0038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0164 0.0164
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0828 0.0989
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0323 0.0335
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1253 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0369 0.0369
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0262 0.0294
Echinococcus granulosus neuropeptide receptor 0.0982 0.7814 0.8114
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0236 0.0727
Loa Loa (eye worm) hypothetical protein 0.0258 0.1953 0.1953
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0135 0.0417
Brugia malayi Pre-SET motif family protein 0.0902 0.7161 0.7161
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.034 0.0353
Mycobacterium leprae Probable lipase LipE 0.0036 0.0164 0.1192
Onchocerca volvulus 0.1027 0.8171 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0139 0.0139
Loa Loa (eye worm) G-protein coupled receptor 0.0982 0.7814 0.7814
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0135 0.0141
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0042 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0046 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0418 0.3248 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0164
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0982 0.7814 0.7814
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0046 0.0046
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0323 0.0369
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0982 0.7814 0.8114
Schistosoma mansoni hypothetical protein 0.0023 0.0053 0.0055
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0104 0.0321
Loa Loa (eye worm) hypothetical protein 0.0105 0.0721 0.0721
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0205 0.063
Echinococcus multilocularis g-protein coupled receptor 0.0982 0.7814 0.8114
Plasmodium vivax SET domain protein, putative 0.0129 0.0916 0.2821
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0164 0.0941
Giardia lamblia DINP protein human, muc B family 0.0041 0.0205 0.0764
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.1074 0.1115
Schistosoma mansoni hypothetical protein 0.037 0.2864 0.2974
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0418 0.3248 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Brugia malayi Inositol-1 0.0037 0.0168 0.0168
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0053 0.0162
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0323 0.0369
Toxoplasma gondii hypothetical protein 0.0023 0.0054 0.0165
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0129 0.0408
Loa Loa (eye worm) cytochrome P450 0.0023 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0369
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0356 0.037
Schistosoma mansoni lamin 0.0061 0.0364 0.0378
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0129 0.0131
Schistosoma mansoni loxhd1 0.0021 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.2471 0.7608
Toxoplasma gondii ABC1 family protein 0.0036 0.0164 0.0506
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0364 0.0364
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0164 0.0174
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0364 0.0364
Leishmania major DNA polymerase kappa, putative 0.0041 0.0205 0.063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0046 0.0046
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0369
Schistosoma mansoni single-minded 0.0057 0.0333 0.0346
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0054 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0323 0.0323
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0323 0.0993
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0129 0.5
Schistosoma mansoni lamin 0.0061 0.0364 0.0378
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0046 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0046 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0828 0.3433
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Leishmania major importin beta-1 subunit, putative 0.0023 0.006 0.0185
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0205 0.1279
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0828 0.2548
Echinococcus multilocularis serotonin receptor 0.0982 0.7814 0.8114
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0323 0.0323
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0387 0.0402
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0387 0.0402
Echinococcus granulosus neuropeptides capa receptor 0.0982 0.7814 0.8114
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.1201 0.1201
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0046 0.0047
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi isocitrate dehydrogenase 0.0033 0.0135 0.0135
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0982 0.7814 0.8114
Schistosoma mansoni neuropeptide receptor 0.0982 0.7814 0.8114
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0982 0.7814 0.8114
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0054 0.0165
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0828 0.2548
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.2164 1
Echinococcus multilocularis lamin dm0 0.0061 0.0364 0.0378
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0205 0.0212
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0916 0.0951
Echinococcus granulosus tm gpcr rhodopsin 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0129 0.0397
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0135 0.0417
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0038
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0205 0.0205
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0205 0.063
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.1317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0993
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0452 0.0452
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0828 0.0859
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0229 0.088
Echinococcus granulosus biogenic amine 5HT receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1207 0.963 1
Brugia malayi neuropeptide F receptor 0.0982 0.7814 0.7814
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0418 0.3248 1
Brugia malayi nuclear hormone receptor 0.0022 0.0046 0.0046
Brugia malayi hypoxia-induced factor 1 0.0177 0.1301 0.1301
Echinococcus granulosus snurportin 1 0.0309 0.2366 0.2457
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0164 0.0659
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.1074 0.1115
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0828 0.0859
Schistosoma mansoni ran 0.0021 0.0042 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0053 0.0053
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0982 0.7814 0.8114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0046 0.0046
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Trypanosoma brucei unspecified product 0.0028 0.0101 0.0311
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0046 0.0047
Schistosoma mansoni hypothetical protein 0.0982 0.7814 0.8114
Echinococcus granulosus tachykinin peptides receptor 99D 0.0982 0.7814 0.8114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0721 0.0721
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0364 0.0364
Onchocerca volvulus 0.0036 0.0164 0.0155
Mycobacterium ulcerans beta-lactamase 0.0036 0.0164 0.0941
Echinococcus granulosus hypothetical protein 0.0982 0.7814 0.8114
Brugia malayi neuropeptide F receptor 0.0982 0.7814 0.7814
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0046 0.0046
Schistosoma mansoni neuropeptide receptor 0.0982 0.7814 0.8114
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0953 0.7577 0.7868
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0079 0.0506 0.0525
Schistosoma mansoni survival motor neuron protein 0.0053 0.0295 0.0306
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0369
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0982 0.7814 0.956
Brugia malayi intermediate filament protein 0.0061 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0068
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0387 0.1193
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0053 0.0162
Giardia lamblia Hypothetical protein 0.0056 0.0323 0.132
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.2471 0.7608
Schistosoma mansoni hypothetical protein 0.037 0.2864 0.2974
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0104 0.0321
Schistosoma mansoni neuropeptide f receptor 76f 0.0982 0.7814 0.8114
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.0516
Echinococcus granulosus 7TM GPCR rhodopsin 0.0982 0.7814 0.8114
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0046 0.0047
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0205 0.0224
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0982 0.7814 0.8114
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0387 0.0402
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0164 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0375 0.0432
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0982 0.7814 0.7814
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0046 0.0047
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0356 0.037
Brugia malayi beta-lactamase family protein 0.0036 0.0164 0.0164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0139 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Onchocerca volvulus 0.0982 0.7814 0.956
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0827 0.2545
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0046 0.0046
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0827 0.2545
Echinococcus granulosus adenylate cyclase 9 0.0092 0.0618 0.0641
Schistosoma mansoni growth hormone secretagogue receptor 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0323 0.0993
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0168 0.0174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0131
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1101 0.3391
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0168 0.5
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0519 0.0539
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0323 0.0369
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.0753 0.2318
Schistosoma mansoni hypothetical protein 0.0053 0.0295 0.0306
Mycobacterium tuberculosis Conserved protein 0.0036 0.0164 0.0659
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0164 0.0941
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0139 0.0139
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0139 0.0145
Echinococcus granulosus allatostatin A receptor 0.0982 0.7814 0.8114
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0827 0.2545
Brugia malayi Dopamine receptor protein 2 0.0982 0.7814 0.7814
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0982 0.7814 0.8114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0164 0.0506
Brugia malayi 6-phosphofructokinase 0.0118 0.0828 0.0828
Giardia lamblia hypothetical protein 0.0056 0.0323 0.132
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0982 0.7814 0.8114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.1201 0.1247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0916 0.0951
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0068 0.2114
Brugia malayi cytochrome P450 0.0023 0.0053 0.0053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0205 0.0212
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Echinococcus multilocularis dna polymerase eta 0.0041 0.0205 0.0212
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0982 0.7814 0.8114
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.0753 0.2318
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0164 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0388 0.0402
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1207 0.963 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.006 0.0185
Brugia malayi MAP kinase sur-1 0.0109 0.0753 0.0753
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0506 0.0593
Brugia malayi Doublecortin family protein 0.0021 0.0038 0.0038
Loa Loa (eye worm) PDE1B protein 0.1207 0.963 0.963
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.0323 0.0335
Schistosoma mansoni importin beta-1 0.0029 0.0104 0.0108
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0982 0.7814 0.8114
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.0042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0168 0.0968
Trichomonas vaginalis importin beta-1, putative 0.0023 0.006 0.0046
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0993
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0135 0.0141
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0046 0.0047
Echinococcus multilocularis lamin 0.0061 0.0364 0.0378
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.0753 0.2318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.2134 0.2216
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0991 0.7899
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0046 0.0009
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0323 0.0993
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0916 0.0951
Echinococcus granulosus dna polymerase eta 0.0041 0.0205 0.0212
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Onchocerca volvulus 0.0982 0.7814 0.956
Echinococcus granulosus g protein coupled receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.0753 0.0782
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0982 0.7814 0.8114
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0345 0.2664 0.2664
Brugia malayi ecdysteroid receptor 0.0022 0.0046 0.0046
Schistosoma mansoni biogenic amine receptor 0.0982 0.7814 0.8114
Schistosoma mansoni opsin-like receptor 0.0982 0.7814 0.8114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Brugia malayi phosphofructokinase 0.0118 0.0828 0.0828
Brugia malayi Pre-SET motif family protein 0.0129 0.0916 0.0916
Echinococcus granulosus g protein coupled receptor 0.0982 0.7814 0.8114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0387 0.2818
Echinococcus granulosus tar DNA binding protein 0.0064 0.0388 0.0402
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0135 0.0141
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0053 0.0162
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0982 0.7814 0.8114
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0229 0.088
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0982 0.7814 0.8114
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0164 0.0174
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0205 0.0205
Trichomonas vaginalis ran, putative 0.0021 0.0042 0.0025
Brugia malayi Cytochrome P450 family protein 0.0023 0.0053 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0131
Echinococcus multilocularis musashi 0.0061 0.0364 0.0378
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.034 0.0353
Brugia malayi beta-lactamase 0.0036 0.0164 0.0164
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0753 0.0897
Brugia malayi putative neuropeptide receptor NPR1 0.0982 0.7814 0.7814
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1207 0.963 1
Brugia malayi RE15519p 0.0982 0.7814 0.7814
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0054 0.0007
Brugia malayi RNA, U transporter 1 0.0082 0.0535 0.0535
Schistosoma mansoni intermediate filament proteins 0.0061 0.0364 0.0378
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0038 0.1186
Leishmania major DNA polymerase eta, putative 0.0041 0.0205 0.063
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0164 0.1192
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Echinococcus granulosus dna polymerase kappa 0.0041 0.0205 0.0212
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Trypanosoma brucei unspecified product 0.0028 0.0101 0.0311
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0827 0.2545
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Trypanosoma brucei protein kinase, putative 0.0109 0.0753 0.2318
Brugia malayi Importin beta-1 subunit 0.0029 0.0104 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0845 0.0845
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0205 0.063
Echinococcus granulosus lamin dm0 0.0061 0.0364 0.0378
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0046 0.0047
Loa Loa (eye worm) hypothetical protein 0.0061 0.0364 0.0364
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0828 0.0989
Echinococcus multilocularis neuropeptide receptor A26 0.0982 0.7814 0.8114
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0101 0.0311
Schistosoma mansoni rab6-interacting 0.0021 0.0038 0.004
Onchocerca volvulus 0.0982 0.7814 0.956
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.1953 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0375 0.0432
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0068 0.021
Echinococcus multilocularis g protein coupled receptor 0.0982 0.7814 0.8114
Echinococcus granulosus neuropeptides capa receptor 0.0982 0.7814 0.8114
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0054 0.0007
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.0753 0.0782
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0356 0.0356
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0046 0.0009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0982 0.7814 0.8114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0135 0.0141
Brugia malayi Dopamine receptor protein 1 0.0982 0.7814 0.7814
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.2164 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0205 0.0895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Onchocerca volvulus 0.0982 0.7814 0.956
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.0753 0.2318
Onchocerca volvulus Neuropeptide F receptor homolog 0.0982 0.7814 0.956
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0164 0.0174
Schistosoma mansoni amine GPCR 0.0982 0.7814 0.8114
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0982 0.7814 0.7814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0164 0.0171
Echinococcus multilocularis neuropeptide s receptor 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0845 0.0845
Loa Loa (eye worm) hypothetical protein 0.0192 0.1421 0.1421
Schistosoma mansoni biogenic amine receptor 0.0982 0.7814 0.8114
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0109 0.0113
Brugia malayi Serotonin receptor 0.0982 0.7814 0.7814
Echinococcus granulosus sex peptide receptor 0.0982 0.7814 0.8114
Brugia malayi hypothetical protein 0.0149 0.1074 0.1074
Echinococcus granulosus fmrfamide receptor 0.0982 0.7814 0.8114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0418 0.3248 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0916 0.0951
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0068 0.2114
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0135 0.0141
Onchocerca volvulus 0.0982 0.7814 0.956
Brugia malayi Serotonin receptor 0.0982 0.7814 0.7814
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0164 0.0506
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0164 0.0659
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Schistosoma mansoni biogenic amine receptor 0.0982 0.7814 0.8114
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0056 0.0323 0.132
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0356 0.037
Brugia malayi hypothetical protein 0.0192 0.1421 0.1421
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0042 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Leishmania major GTP-binding protein, putative 0.0021 0.0042 0.0131
Echinococcus multilocularis neuropeptides capa receptor 0.0982 0.7814 0.8114
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0145
Onchocerca volvulus 0.0053 0.0295 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.2134 0.2216
Trichomonas vaginalis esterase, putative 0.0036 0.0164 0.0174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.0516
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0038
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0236 0.0727
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0982 0.7814 0.8114
Brugia malayi steroid hormone receptor 0.0022 0.0046 0.0046
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0164 0.0659
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Onchocerca volvulus 0.0982 0.7814 0.956
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2164 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0038 0.004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0982 0.7814 0.7814
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0046 0.0047
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0079 0.0506 0.0506
Brugia malayi MH2 domain containing protein 0.0121 0.0845 0.0845
Onchocerca volvulus 0.0982 0.7814 0.956
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0129 0.0408
Echinococcus granulosus g-protein coupled receptor 0.0982 0.7814 0.8114
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.0753 0.2318
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni hypothetical protein 0.0149 0.1074 0.1115
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0982 0.7814 0.7814
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0205 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0323 0.0993
Echinococcus multilocularis fmrfamide receptor 0.0982 0.7814 0.8114
Schistosoma mansoni amine GPCR 0.0982 0.7814 0.8114
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0164 0.0171
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0088 0.0586 0.0586
Schistosoma mansoni hypothetical protein 0.0982 0.7814 0.8114
Brugia malayi beta-lactamase family protein 0.0036 0.0164 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0164 0.0659
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0323 0.0335
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0079 0.0506 0.0593
Echinococcus multilocularis neuropeptides capa receptor 0.0982 0.7814 0.8114
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0388 0.0402
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0053 0.0055
Onchocerca volvulus 0.0088 0.0586 0.0673
Leishmania major cytochrome p450-like protein 0.0023 0.0053 0.0162
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0046 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0046 0.0046
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0164 0.0171
Brugia malayi jmjC domain containing protein 0.006 0.0356 0.0356
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0131
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0054 0.0009
Echinococcus multilocularis fmrfamide receptor 0.0982 0.7814 0.8114
Echinococcus granulosus intermediate filament protein 0.0061 0.0364 0.0378
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0827 0.0987
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0388 0.0402
Echinococcus granulosus g protein coupled receptor 0.0982 0.7814 0.8114
Echinococcus granulosus importin subunit beta 1 0.0029 0.0104 0.0108
Loa Loa (eye worm) nuclear hormone receptor 0.0101 0.0687 0.0687
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0828 0.0828
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0828 0.0828
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0042 0.0131
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0993
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0046 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.124 0.7001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0205 0.0205
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0054 0.0005
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0828 0.3701
Echinococcus granulosus single minded 2 0.0042 0.0213 0.0221
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0205 0.0895
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0135 0.0135
Echinococcus granulosus GPCR family 2 0.0033 0.0139 0.0145
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0387 0.0402
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.0753 0.0782
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0982 0.7814 0.8114
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0356 0.037
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi G-protein coupled receptor 0.0982 0.7814 0.7814
Echinococcus multilocularis neuropeptide Y receptor 0.0982 0.7814 0.8114
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0164 0.0506
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0213 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0388 0.0402
Brugia malayi Tachykinin-like peptides receptor 99D 0.0982 0.7814 0.7814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0375 0.0432
Brugia malayi Dopamine receptor 0.0982 0.7814 0.7814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0164 0.0506
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0982 0.7814 0.8114
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0323 0.0993
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0323 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0164 0.0659
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0323 0.0993
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0054 0.0165
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0046 0.0009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Leishmania major cytochrome p450-like protein 0.0023 0.0053 0.0162
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0982 0.7814 0.8114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0354 0.1091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0046 0.0047
Echinococcus granulosus dro:myosuppressin receptor 0.0982 0.7814 0.8114
Onchocerca volvulus 0.0982 0.7814 0.956
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0046 0.0046
Brugia malayi TAR-binding protein 0.0064 0.0388 0.0388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Echinococcus multilocularis somatostatin receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0038 0.004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0753 0.0897
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0205 0.063
Schistosoma mansoni microtubule-associated protein tau 0.0783 0.6206 0.6444
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.01
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0129 0.0397
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Mycobacterium ulcerans hypothetical protein 0.0036 0.0164 0.0941
Entamoeba histolytica hypothetical protein 0.0149 0.1074 0.4863
Schistosoma mansoni neuropeptide F-like receptor 0.0982 0.7814 0.8114
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0354 0.1091
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0213 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0101 0.0311
Echinococcus multilocularis GPCR, family 2 0.0033 0.0139 0.0145
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.2471 0.7608
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0053 0.0162
Brugia malayi Cytochrome P450 family protein 0.0023 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0982 0.7814 0.8114
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0262 0.0806
Loa Loa (eye worm) melatonin receptor type 1A 0.0982 0.7814 0.7814
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0262 0.0806
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1749 1
Echinococcus multilocularis adenylate cyclase type IX 0.013 0.092 0.0956
Schistosoma mansoni hypothetical protein 0.0072 0.0452 0.0469
Loa Loa (eye worm) hypothetical protein 0.0056 0.0323 0.0323
Brugia malayi Cytochrome P450 family protein 0.0062 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0164
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0418 0.3248 0.3373
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0982 0.7814 0.8114
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.1207 0.963 0.963
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus multilocularis RUN 0.0021 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0109 0.0113
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0418 0.3248 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0046 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.0982 0.7814 0.8114
Echinococcus granulosus geminin 0.037 0.2864 0.2974
Echinococcus granulosus neuropeptide Y receptor 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.2134 0.2216
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0916 0.2821
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0136 0.0893
Loa Loa (eye worm) adenylyl cyclase 3 0.0218 0.1636 0.1636
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0827 0.0987
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0323 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0054 0.0038
Schistosoma mansoni neuropeptide F-like receptor 0.0982 0.7814 0.8114
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0982 0.7814 0.8114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0046 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0112 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0355
Onchocerca volvulus 0.0092 0.0618 0.0712
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0323 0.0369
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0129 0.3999
Brugia malayi RNA binding protein 0.0064 0.0388 0.0388
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0079 0.0506 0.0525
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Brugia malayi hypothetical protein 0.0021 0.0038 0.0038
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0135 0.0141
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0092 0.0618 0.0712
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1101 0.3391
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0092 0.0618 0.0712
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0096 0.0644 0.0763
Brugia malayi Adenylyl cyclase protein 0.0092 0.0618 0.0618
Leishmania major cytochrome p450-like protein 0.0023 0.0053 0.0162
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0828 0.0989
Loa Loa (eye worm) neuropeptide F receptor 0.0982 0.7814 0.7814
Schistosoma mansoni biogenic amine (5HT) receptor 0.0982 0.7814 0.8114
Trypanosoma brucei unspecified product 0.0041 0.0205 0.063
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0982 0.7814 0.8114
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0135 0.0417
Echinococcus granulosus orexin receptor type 2 0.0982 0.7814 0.8114
Brugia malayi 6-phosphofructokinase 0.0118 0.0828 0.0828
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.1164 0.1208
Onchocerca volvulus 0.0982 0.7814 0.956
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0387 0.2818
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0164
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0388 0.0388
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0164 0.0164
Schistosoma mansoni jumonji domain containing protein 0.006 0.0356 0.037
Onchocerca volvulus 0.0982 0.7814 0.956
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.2471 0.7608
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0168 0.059
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0993
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Echinococcus granulosus adenylate cyclase type IX 0.013 0.092 0.0956
Echinococcus granulosus Solute carrier family 22 5 0.1206 0.9624 0.9993
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0205 0.063
Schistosoma mansoni rab6-interacting 0.0021 0.0038 0.004
Schistosoma mansoni lipoxygenase 0.0058 0.034 0.0353
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0042 0.0131
Mycobacterium ulcerans hypothetical protein 0.0169 0.124 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0356 0.037
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0054 0.1659
Schistosoma mansoni opsin-like receptor 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi PAS domain containing protein 0.0057 0.0333 0.0333
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0135 0.0417
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0323 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0205 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0023 0.006 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0131
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.2366 0.2366
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0387 0.1193
Schistosoma mansoni alpha-1 adrenergic receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis orexin receptor type 2 0.0982 0.7814 0.8114
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0168 0.0174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0982 0.7814 0.8114
Plasmodium vivax importin-beta 2, putative 0.0029 0.0104 0.0321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0387 0.2818
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0323 0.0993
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0205 0.063
Schistosoma mansoni ran 0.0021 0.0042 0.0044
Echinococcus multilocularis G protein coupled receptor 139 0.0982 0.7814 0.8114
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0038 0.004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0205 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0753 0.0897
Onchocerca volvulus 0.0061 0.0364 0.0401
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0387 0.1973
Toxoplasma gondii hypothetical protein 0.0023 0.0054 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.2134 0.2216
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0129 0.0397
Echinococcus multilocularis dro:myosuppressin receptor 0.0982 0.7814 0.8114
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0323 0.0993
Schistosoma mansoni histamine h1 receptor 0.0982 0.7814 0.8114
Mycobacterium tuberculosis Conserved protein 0.0036 0.0164 0.0659
Schistosoma mansoni amine GPCR 0.0982 0.7814 0.8114
Brugia malayi nuclear receptor NHR-88 0.0022 0.0046 0.0046
Schistosoma mansoni inositol monophosphatase 0.0037 0.0168 0.0174
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0827 0.2545
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus granulosus neuropeptide FF receptor 2 0.0982 0.7814 0.8114
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0205 0.063
Echinococcus granulosus tm gpcr rhodopsin 0.0982 0.7814 0.8114
Echinococcus multilocularis neuropeptide receptor 0.0982 0.7814 0.8114
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.0753 0.3349
Leishmania major hypothetical protein, conserved 0.0056 0.0323 0.0993
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0753 0.0897
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0982 0.7814 0.8114
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0046 0.0047
Schistosoma mansoni cytochrome P450 0.0023 0.0053 0.0055
Echinococcus granulosus neuropeptide s receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0046 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0164
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0164 0.0174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.0516
Brugia malayi sulfakinin receptor protein 0.0982 0.7814 0.7814
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0418 0.3248 0.3373
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0104 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0139
Loa Loa (eye worm) RNA binding protein 0.0064 0.0388 0.0388
Onchocerca volvulus 0.0982 0.7814 0.956
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi hypothetical protein 0.0024 0.0068 0.0068
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0262 0.0294
Loa Loa (eye worm) inositol-1 0.0037 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0104 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0753 0.0782
Echinococcus multilocularis sex peptide receptor 0.0982 0.7814 0.8114
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0323 0.0993
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0129 0.0397
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0046 0.0047
Brugia malayi GnHR receptor homolog 0.0982 0.7814 0.7814
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0038 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0168 0.0178
Echinococcus multilocularis allatostatin A receptor 0.0982 0.7814 0.8114
Schistosoma mansoni amine GPCR 0.0982 0.7814 0.8114
Onchocerca volvulus 0.0042 0.0213 0.0214
Loa Loa (eye worm) hypothetical protein 0.0129 0.0916 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0046 0.0046
Toxoplasma gondii hypothetical protein 0.0052 0.029 0.0893
Echinococcus multilocularis microtubule associated protein 2 0.0783 0.6206 0.6444
Schistosoma mansoni coup transcription factor 0.0022 0.0046 0.0047
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0053 0.0162
Schistosoma mansoni DNA polymerase eta 0.0041 0.0205 0.0212
Loa Loa (eye worm) hypothetical protein 0.0102 0.0697 0.0697
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0828 0.0859
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Echinococcus granulosus microtubule associated protein 2 0.0783 0.6206 0.6444
Onchocerca volvulus 0.0982 0.7814 0.956
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0139 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0046 0.0046
Echinococcus granulosus neuropeptide receptor 0.0982 0.7814 0.8114
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.1953 0.2028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0356 0.037
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0046 0.0047
Onchocerca volvulus 0.0982 0.7814 0.956
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0135 0.0417
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0262 0.0272
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0418 0.3248 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0046 0.0046
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0164 0.0659
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.0753 0.0782
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0323 0.0369
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0046 0.0047
Toxoplasma gondii hypothetical protein 0.0062 0.0375 0.1153
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.0753 0.2318
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0135 0.4198
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 0.0369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0827 0.0858
Onchocerca volvulus 0.0129 0.0916 0.1079
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0205 0.063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.0753 0.2318
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0129 0.3999
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Echinococcus granulosus peptide allatostatin:somatostatin 0.0982 0.7814 0.8114
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.0516
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0916 0.0951
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0982 0.7814 0.8114
Entamoeba histolytica hypothetical protein 0.0149 0.1074 0.4863
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.006 0.0046
Brugia malayi jmjC domain containing protein 0.006 0.0356 0.0356
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0827 0.0987
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0168 0.0178
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0333 0.0346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.028 0.2134 0.2134
Brugia malayi hypothetical protein 0.0133 0.0942 0.0942
Echinococcus granulosus G protein coupled receptor 139 0.0982 0.7814 0.8114
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0135 0.0417
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0139 0.0139
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0038 0.004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0236 0.0727
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0828 0.0989
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.2134 0.2216
Mycobacterium ulcerans lipase LipD 0.0036 0.0164 0.0941
Onchocerca volvulus 0.0982 0.7814 0.956
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi larval opioid receptor 0.0982 0.7814 0.7814
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0991 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0096 0.0644 0.0763
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.01
Echinococcus multilocularis g protein coupled receptor 0.0982 0.7814 0.8114
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.0323 0.0335
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0068 0.021
Onchocerca volvulus 0.0061 0.0364 0.0401
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0068 0.021
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0323 0.0369
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.0323 0.0335
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0038 0.0118
Echinococcus granulosus tm gpcr rhodopsin 0.0982 0.7814 0.8114
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0323 0.0323
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0042 0.0131
Brugia malayi G protein-coupled receptor F59B2.13 0.0982 0.7814 0.7814
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0046 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0229 0.7102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.2134 0.2216
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0323 0.0369
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0982 0.7814 0.7814
Loa Loa (eye worm) acetyltransferase 0.0165 0.1201 0.1201
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0046 0.0047
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0828 0.4568
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0046 0.0047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.1074 0.1115
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0323 0.0335
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0323 0.0993
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0982 0.7814 0.7814
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0902 0.7161 0.7161
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Entamoeba histolytica hypothetical protein 0.0149 0.1074 0.4863
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0323 0.0369
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0168 0.0516
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0519 0.0539
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0982 0.7814 0.8114
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0164 0.0659
Loa Loa (eye worm) beta-lactamase 0.0036 0.0164 0.0164
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0982 0.7814 0.8114
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0046 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0828 0.8261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0139 0.0145
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0129 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0205 0.1279
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0046 0.0047
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0323 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0323 1
Schistosoma mansoni hypothetical protein 0.0309 0.2366 0.2457
Onchocerca volvulus 0.0982 0.7814 0.956
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.0753 0.0753
Echinococcus multilocularis neuropeptide FF receptor 2 0.0982 0.7814 0.8114
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0323 0.0993
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Echinococcus multilocularis serotonin receptor 0.0982 0.7814 0.8114
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0131
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0038 0.004
Leishmania major hypothetical protein, conserved 0.0036 0.0164 0.0506
Entamoeba histolytica hypothetical protein 0.0149 0.1074 0.4863
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0118 0.0827 0.0858
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0053 0.0162
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Schistosoma mansoni adenoreceptor 0.0982 0.7814 0.8114
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0068 0.021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0168 0.0178
Echinococcus multilocularis 0.0023 0.0053 0.0055
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0828 0.0859
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0046 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0316 0.0973
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0164
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Brugia malayi hypothetical protein 0.0258 0.1953 0.1953
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0828 0.3701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0916 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0262 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0827 0.0987
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0135 0.0417
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0129 0.0397
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0092 0.0618 0.0618
Loa Loa (eye worm) hypoxia-induced factor 1 0.0177 0.1301 0.1301
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0054 0.0005
Brugia malayi ORL1-like opioid receptor 0.0982 0.7814 0.7814
Loa Loa (eye worm) hypothetical protein 0.0056 0.0323 0.0323
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2164 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0982 0.7814 0.8114
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Brugia malayi putative neuropeptide receptor 0.0982 0.7814 0.7814
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Plasmodium falciparum importin beta, putative 0.0029 0.0104 0.323
Schistosoma mansoni inositol monophosphatase 0.0037 0.0168 0.0174
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0828 0.3701
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0323 0.0335
Echinococcus granulosus rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Schistosoma mansoni amine GPCR 0.0982 0.7814 0.8114
Loa Loa (eye worm) TYRA-2 protein 0.0982 0.7814 0.7814
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0042 0.0044
Schistosoma mansoni hypothetical protein 0.0982 0.7814 0.8114
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0982 0.7814 0.8114
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0236 0.0727
Onchocerca volvulus 0.0036 0.0164 0.0155
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0079 0.0506 0.0525
Schistosoma mansoni hypothetical protein 0.0021 0.0038 0.004
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0418 0.3248 1
Echinococcus granulosus neuropeptide receptor A26 0.0982 0.7814 0.8114
Echinococcus granulosus somatostatin receptor 0.0982 0.7814 0.8114
Echinococcus multilocularis g protein coupled receptor 0.0982 0.7814 0.8114
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0205 0.0764
Brugia malayi AKH receptor 0.0982 0.7814 0.7814
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0205 0.0212
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.0753 0.2318
Brugia malayi G-protein coupled receptor 0.0982 0.7814 0.7814
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0991 0.553
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0112 0.0779 0.0809
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.0323 0.0335
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0079 0.0506 0.0506
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Onchocerca volvulus 0.0982 0.7814 0.956
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.1201 0.1247
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Brugia malayi hypothetical protein 0.0982 0.7814 0.7814
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0112 0.0779 0.0809
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0982 0.7814 0.7814
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0096 0.0644 0.1982
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0982 0.7814 0.7814
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0046 0.0047
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0827 0.0987
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2164 0.2629
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0828 0.6525
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0046 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0046 0.0047
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0323 0.0335
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0205 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0101 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0046 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0388 0.0402
Onchocerca volvulus 0.0036 0.0164 0.0155
Leishmania major hypothetical protein, conserved 0.0024 0.0068 0.021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0104

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5900 nM Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes ChEMBL. 16134949
IC50 (binding) = 5900 nM Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes ChEMBL. 16134949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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