Detailed information for compound 376961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1029.99 | Formula: C49H72BN13O11
  • H donors: 13 H acceptors: 12 LogP: -1.6 Rotable bonds: 36
    Rule of 5 violations (Lipinski): 4
  • SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)[C@H](CC)C)Cc1ccc(cc1)B(O)O)C(C)C)CCCN=C(N)N
  • InChi: 1S/C49H72BN13O11/c1-6-29(4)41(46(69)59-36(24-33-25-54-27-56-33)47(70)63-21-11-15-38(63)44(67)60-37(48(71)72)23-30-12-8-7-9-13-30)62-43(66)35(22-31-16-18-32(19-17-31)50(73)74)58-45(68)40(28(2)3)61-42(65)34(57-39(64)26-53-5)14-10-20-55-49(51)52/h7-9,12-13,16-19,25,27-29,34-38,40-41,53,73-74H,6,10-11,14-15,20-24,26H2,1-5H3,(H,54,56)(H,57,64)(H,58,68)(H,59,69)(H,60,67)(H,61,65)(H,62,66)(H,71,72)(H4,51,52,55)/t29-,34-,35-,36-,37-,38+,40-,41-/m0/s1
  • InChiKey: MRTRTIMZRPAQMR-BBAZYHAFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0011 0.0011 0.0085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0067 0.0216 0.0216
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0116 0.1245
Entamoeba histolytica Ran family GTPase 0.0068 0.022 0.8911
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0141 0.0174
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0085 0.0105
Schistosoma mansoni DNA ligase IV 0.0021 0.0047 0.0058
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.0858
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0856
Schistosoma mansoni cpg binding protein 0.0036 0.0102 0.0125
Echinococcus multilocularis ferritin 0.0009 0.0003 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.053 0.1925 0.2365
Mycobacterium ulcerans aldehyde dehydrogenase 0.0207 0.0735 1
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0429 0.1187
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0047 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.2212 0.8141 0.8141
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0047 0.014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0224 0.0224
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0067 0.0216 0.0265
Schistosoma mansoni importin-beta 2 0.0017 0.0033 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0067 0.0216 0.0307
Toxoplasma gondii aldehyde dehydrogenase 0.0207 0.0735 0.2792
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0011 0.0011 0.1746
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0011 0.0011 0.003
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0011 0.0011 0.0105
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Brugia malayi hypothetical protein 0.0138 0.0479 0.0681
Mycobacterium ulcerans hypothetical protein 0.004 0.0116 0.1545
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0067 0.0216 0.0265
Onchocerca volvulus 0.0032 0.0085 0.0085
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0000083579 0.0000083579
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.1822
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0011 0.0011 0.0085
Mycobacterium leprae Probable lipase LipE 0.004 0.0116 1
Leishmania major importin beta-1 subunit, putative 0.0075 0.0246 0.0898
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0066 0.2341
Schistosoma mansoni ferritin light chain 0.0009 0.0003 0.0004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0116 0.1245
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0085 0.0121
Echinococcus multilocularis expressed protein 0.0009 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.4926
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0033 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0011 0.0013
Brugia malayi hypothetical protein 0.0035 0.0099 0.0141
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0003
Brugia malayi ecdysone receptor 0.0032 0.0085 0.0121
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.1822
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0047 0.014
Echinococcus granulosus importin 5 0.0017 0.0033 0.0041
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0011 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0108 0.0368 0.0452
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Schistosoma mansoni ferritin 0.0009 0.0003 0.0004
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0041 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0216 0.0307
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0003 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0216 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0067 0.0216 0.0307
Echinococcus granulosus ferritin 0.0009 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0013
Plasmodium vivax telomerase reverse transcriptase, putative 0.0719 0.2624 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0099 0.0099
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.0085 0.0085
Schistosoma mansoni ferritin light chain 0.0009 0.0003 0.0004
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0141 0.0141
Schistosoma mansoni RAR-like nuclear receptor 0.0067 0.0216 0.0265
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0011 0.0011 0.0683
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0033 0.0092
Mycobacterium ulcerans beta-lactamase 0.004 0.0116 0.1545
Schistosoma mansoni ferritin 0.0009 0.0003 0.0004
Brugia malayi orphan nuclear receptor NR2E1 0.0032 0.0085 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.1822
Echinococcus multilocularis dnaJ subfamily B 0.0485 0.1762 0.1762
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0011 0.0011 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0008
Brugia malayi tailless protein 0.0032 0.0085 0.0121
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.0085 0.0236
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0131
Treponema pallidum DNA ligase (lig) 0.0021 0.0047 1
Brugia malayi nuclear receptor NHR-88 0.0032 0.0085 0.0121
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0011 0.0011 0.0105
Echinococcus granulosus translational activator gcn1 0.0017 0.0033 0.0041
Onchocerca volvulus 0.0026 0.0066 0.0065
Mycobacterium leprae conserved hypothetical protein 0.004 0.0116 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0116 0.4662
Mycobacterium ulcerans aldehyde dehydrogenase 0.0207 0.0735 1
Onchocerca volvulus 0.004 0.0116 0.0117
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0003 0.0004
Trypanosoma cruzi importin beta-1 subunit, putative 0.0075 0.0246 0.0898
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0085 0.0105
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0041 0.0031
Onchocerca volvulus 0.004 0.0116 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0067 0.0216 0.0307
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0047 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0099 0.0141
Mycobacterium ulcerans lipase LipD 0.004 0.0116 0.1545
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0321
Echinococcus multilocularis FTZ F1 alpha 0.0067 0.0216 0.0216
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0047 0.014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0067 0.0216 0.0265
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0011 0.0011 0.0105
Schistosoma mansoni nuclear receptor nhr-48 0.0032 0.0085 0.0105
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0047 0.0058
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0011 0.0011
Brugia malayi Aldehyde dehydrogenase protein 4 0.0011 0.0011 0.0015
Schistosoma mansoni coup transcription factor 0.0067 0.0216 0.0265
Schistosoma mansoni cpg binding protein 0.0034 0.0095 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0067 0.0216 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0067 0.0216 0.0597
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0068 0.022 0.08
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0165 0.0203
Schistosoma mansoni ran 0.0068 0.022 0.027
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0275
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0041 0.042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Echinococcus multilocularis geminin 0.0543 0.1975 0.1975
Schistosoma mansoni nuclear receptor 0.0032 0.0085 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0075 0.0246 1
Schistosoma mansoni aldehyde dehydrogenase 0.0207 0.0735 0.0903
Schistosoma mansoni dishevelled 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0321
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0224 0.0275
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.4926
Onchocerca volvulus Huntingtin homolog 0.0138 0.0479 0.0492
Echinococcus granulosus snurportin 1 0.0987 0.3614 0.4439
Brugia malayi DKFZp564C0469 protein 0.0021 0.0047 0.0067
Brugia malayi N-terminal motif family protein 0.0188 0.0665 0.0945
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0085 0.0105
Onchocerca volvulus 0.0032 0.0085 0.0085
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0003 0.0003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0032 0.0085 0.0121
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0003 0.0004
Echinococcus multilocularis nibrin 0.0021 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0011 0.0011 0.0105
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0068 0.022 0.08
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0182
Echinococcus multilocularis Smad4 0.0008 0.0000083579 0.0000083579
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0116 0.0165
Echinococcus granulosus microtubule associated protein 2 0.2212 0.8141 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Treponema pallidum gamma-glutamyl phosphate reductase 0.0011 0.0011 0.1746
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.2631 0.969 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0165 0.0203
Brugia malayi hypothetical protein 0.0021 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0003
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0141 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0067 0.0216 0.0597
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.4926
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0066 0.069
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0116 0.1245
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0068 0.022 0.0609
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Plasmodium falciparum telomerase reverse transcriptase 0.0719 0.2624 1
Schistosoma mansoni apoferritin-2 0.0009 0.0003 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0068 0.022 0.08
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0069 0.0224 0.0275
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0085 0.0085
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0011 0.0011
Echinococcus multilocularis neuropeptide s receptor 0.0522 0.1897 0.1897
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0165 0.0165
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0224 0.062
Echinococcus granulosus transportin 1 0.0017 0.0033 0.0041
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.0649 0.0649
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0011 0.0011 0.0318
Brugia malayi beta-lactamase 0.004 0.0116 0.0165
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0032 0.0085 0.0236
Mycobacterium tuberculosis Conserved protein 0.004 0.0116 0.1245
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0011 0.0011 0.0013
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0116 0.1545
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0067 0.0216 0.0307
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.0067 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0219 0.0776 0.1103
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0368 0.0523
Schistosoma mansoni aldehyde dehydrogenase 0.0207 0.0735 0.0903
Loa Loa (eye worm) hypothetical protein 0.0162 0.0566 0.1565
Plasmodium vivax importin-beta 2, putative 0.0092 0.031 0.1069
Loa Loa (eye worm) RNA binding protein 0.0203 0.0719 0.1989
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0067 0.0216 0.0265
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0429 0.1187
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0321
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0165 0.0203
Loa Loa (eye worm) hypothetical protein 0.0053 0.0165 0.0457
Echinococcus multilocularis GPCR, family 2 0.0069 0.0224 0.0224
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0068 0.022 0.08
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0085 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0321
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0011 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.1822
Schistosoma mansoni importin beta-1 0.0092 0.031 0.0381
Schistosoma mansoni hypothetical protein 0.0485 0.1762 0.2165
Trypanosoma brucei telomerase reverse transcriptase 0.0719 0.2624 1
Entamoeba histolytica HEAT repeat domain containing protein 0.0017 0.0033 0.0955
Echinococcus multilocularis tumor protein p63 0.1104 0.4046 0.4046
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0141 0.0391
Echinococcus granulosus GTP binding nuclear protein Ran 0.0068 0.022 0.027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0066 0.0856
Echinococcus granulosus tar DNA binding protein 0.0203 0.0719 0.0883
Schistosoma mansoni ran 0.0068 0.022 0.027
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.0085 0.0236
Schistosoma mansoni hypothetical protein 0.0069 0.0224 0.0275
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0116 0.0143
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0085 0.0085
Echinococcus granulosus ecdysone induced protein 78C 0.0067 0.0216 0.0265
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0216 0.0307
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0165 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0067 0.0216 0.0597
Brugia malayi mbt repeat family protein 0.0047 0.0141 0.0201
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0032 0.0085 0.0105
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0099 0.0141
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0216 0.0265
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0047 0.1553
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0987 0.3614 0.4439
Schistosoma mansoni ferritin 0.0009 0.0003 0.0004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0207 0.0735 0.0735
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0041 0.0521
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Brugia malayi hypothetical protein 0.0043 0.0126 0.018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0066 0.2341
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.0665 0.0683
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0011 0.0011 0.0085
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0141 0.0143
Schistosoma mansoni zinc finger protein 0.0032 0.0085 0.0105
Onchocerca volvulus 0.004 0.0116 0.0117
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0095 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0182
Toxoplasma gondii ABC1 family protein 0.004 0.0116 0.0432
Brugia malayi nuclear hormone receptor 0.0032 0.0085 0.0121
Echinococcus granulosus tumor protein p63 0.1104 0.4046 0.4971
Chlamydia trachomatis DNA ligase 0.0021 0.0047 1
Brugia malayi hypothetical protein 0.0032 0.0085 0.0121
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0003 0.0004
Echinococcus granulosus expressed protein 0.0009 0.0003 0.0004
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0021 0.0047 0.3908
Echinococcus multilocularis neuropeptide receptor A26 0.0522 0.1897 0.1897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0067 0.0216 0.0597
Mycobacterium tuberculosis Conserved protein 0.004 0.0116 0.1245
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0114
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0543 0.1975 0.2427
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0216 0.0265
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0116 0.1245
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0216 0.0307
Brugia malayi beta-lactamase family protein 0.004 0.0116 0.0165
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0011 0.0011 0.0085
Brugia malayi photoreceptor-specific nuclear receptor 0.0067 0.0216 0.0307
Brugia malayi hypothetical protein 0.0021 0.0047 0.0067
Echinococcus multilocularis nuclear receptor nhr 48 0.0032 0.0085 0.0085
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0116 0.1245
Echinococcus granulosus importin subunit beta 1 0.0092 0.031 0.0381
Plasmodium falciparum importin beta, putative 0.0092 0.031 0.1069
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0032 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0141 0.0174
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0011 0.0011 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0067 0.0216 0.0265
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0007 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0116 0.0403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0116 0.0143
Trichomonas vaginalis importin beta-1, putative 0.0075 0.0246 1
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0033 0.0116
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0033 0.0086
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0003 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0085 0.0105
Brugia malayi mbt repeat family protein 0.0047 0.0141 0.0201
Leishmania major hypothetical protein, conserved 0.004 0.0116 0.0403
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0011 0.0013
Brugia malayi RNA, U transporter 1 0.0263 0.094 0.1336
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0047 0.1822
Onchocerca volvulus Protein ultraspiracle homolog 0.0067 0.0216 0.022
Loa Loa (eye worm) hypothetical protein 0.053 0.1925 0.5328
Brugia malayi nuclear receptor NHR-88 0.0067 0.0216 0.0307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0224 0.0224
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0719 0.2624 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0275
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0047 0.1822
Schistosoma mansoni hypothetical protein 0.0543 0.1975 0.2427
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0236 0.029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0067 0.0216 0.0265
Loa Loa (eye worm) beta-lactamase 0.004 0.0116 0.0321
Brugia malayi Calcitonin receptor-like protein seb-1 0.0219 0.0776 0.1103
Loa Loa (eye worm) aldehyde dehydrogenase 0.0011 0.0011 0.003
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0003
Brugia malayi Telomerase reverse transcriptase 0.1913 0.7035 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0099 0.0122
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0068 0.022 0.0721
Mycobacterium tuberculosis Conserved protein 0.004 0.0116 0.1245
Brugia malayi topoisomerase 0.0021 0.0047 0.0067
Brugia malayi nuclear receptor RXR 0.0035 0.0099 0.0141
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0011 0.0011 0.0085
Onchocerca volvulus 0.0034 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0149 0.0521 0.144
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0114
Brugia malayi RNA recognition motif domain containing protein 0.0203 0.0719 0.1022
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0067 0.0216 0.0216
Echinococcus multilocularis transportin 1 0.0017 0.0033 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0099 0.0122
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.0911 1
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0116 0.0321
Echinococcus granulosus FTZ F1 alpha 0.0067 0.0216 0.0265
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0011 0.0011 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0067 0.0216 0.0597
Schistosoma mansoni topbp1 0.0021 0.0047 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0116 0.0403
Schistosoma mansoni hypothetical protein 0.0149 0.0521 0.0639
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0131
Onchocerca volvulus 0.0047 0.0141 0.0143
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0047 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0093
Echinococcus granulosus dnaJ subfamily B 0.0485 0.1762 0.2165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0224 0.0318
Echinococcus multilocularis survival motor neuron protein 1 0.053 0.1925 0.1925
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0216 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0037 0.0376
Mycobacterium ulcerans hypothetical protein 0.0026 0.0066 0.0856
Loa Loa (eye worm) steroid hormone receptor 0.0067 0.0216 0.0597
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0224 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0067 0.0216 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0037 0.0376
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0033 0.0086
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.0085 0.0085
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0011 0.0011 0.0013
Brugia malayi hypothetical protein 0.0032 0.0085 0.0121
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0032 0.0085 0.0121
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0126 0.0155
Loa Loa (eye worm) TAR-binding protein 0.0203 0.0719 0.1989
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0216 0.0216
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0224 0.0318
Loa Loa (eye worm) MBCTL1 0.0053 0.0165 0.0457
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0047 1
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0047 0.014
Schistosoma mansoni tar DNA-binding protein 0.0203 0.0719 0.0883
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0116 0.0143
Schistosoma mansoni cellular tumor antigen P53 0.0162 0.0566 0.0695
Echinococcus granulosus neuropeptide s receptor 0.0522 0.1897 0.233
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0047 0.0604
Onchocerca volvulus Huntingtin homolog 0.0138 0.0479 0.0492
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0856
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0011 0.0011 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0116 0.4662
Brugia malayi CXXC zinc finger family protein 0.0034 0.0095 0.0134
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0011 0.0011 0.0683
Echinococcus multilocularis importin subunit beta 1 0.0092 0.031 0.031
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.021
Schistosoma mansoni nuclear receptor 0.0032 0.0085 0.0105
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0011 0.0011 0.0105
Loa Loa (eye worm) DR-78 0.0032 0.0085 0.0236
Schistosoma mansoni microtubule-associated protein tau 0.2212 0.8141 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0067 0.0216 0.0216
Echinococcus multilocularis importin 5 0.0017 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0116 0.4662
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0011 0.0011 0.0008
Echinococcus multilocularis cpg binding protein 0.0036 0.0102 0.0102
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0068 0.022 0.0828
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0207 0.0735 0.277
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0032 0.0085 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.0092 0.031 0.1172
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0066 0.0856
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0275
Echinococcus multilocularis thyroid hormone receptor alpha 0.0067 0.0216 0.0216
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0047 0.0169
Schistosoma mansoni topbp1 0.0021 0.0047 0.0058
Onchocerca volvulus 0.0162 0.0566 0.0581
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0011 0.0011 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0067 0.0216 0.0307
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0011 0.0011 0.0105
Leishmania major hypothetical protein, conserved 0.0017 0.0033 0.0086
Brugia malayi Steroid receptor seven-up type 2 0.0067 0.0216 0.0307
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.062
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0116 0.1245
Entamoeba histolytica hypothetical protein 0.0075 0.0246 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0522 0.0642
Brugia malayi nuclear receptor RXR 0.0032 0.0085 0.0121
Giardia lamblia Telomerase catalytic subunit 0.0719 0.2624 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0066 0.0856
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0047 0.014
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0008 0.0021
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0047 0.0054
Echinococcus granulosus nibrin 0.0021 0.0047 0.0058
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0085 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0116 0.0403
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0216 0.0265
Schistosoma mansoni cpg binding protein 0.0036 0.0102 0.0125
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0066 0.0856
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0066 0.069
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.0085 0.0105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0207 0.0735 1
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Brugia malayi hypothetical protein 0.053 0.1925 0.2737
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0032 0.0085 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0067 0.0216 0.022
Entamoeba histolytica hypothetical protein 0.0021 0.0047 0.1553
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0003 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0521 0.074
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0067 0.0216 0.0307
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0856
Echinococcus multilocularis smad 0.0008 0.0000083579 0.0000083579
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.021
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0003 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.0522 0.0642
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0000083579 0.0000083579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.0522 0.0642
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Echinococcus multilocularis translational activator gcn1 0.0017 0.0033 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0067 0.0216 0.0265
Trichomonas vaginalis hypothetical protein 0.0017 0.0033 0.1243
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0066 0.5544
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0116 0.4662
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0131
Schistosoma mansoni ferritin 0.0009 0.0003 0.0004
Trichomonas vaginalis esterase, putative 0.004 0.0116 0.4662
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0068 0.022 0.0313
Schistosoma mansoni hypothetical protein 0.0069 0.0224 0.0275
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0011 0.0011 0.0015
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0047 0.1822
Onchocerca volvulus 0.0067 0.0216 0.022
Trichomonas vaginalis ran, putative 0.0068 0.022 0.8945
Brugia malayi kap beta 3 protein 0.0017 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0216 0.0216
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0099 0.0275
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0066 0.5544
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0008 0.0008
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0011 0.0011 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0047 0.1822
Schistosoma mansoni tar DNA-binding protein 0.0203 0.0719 0.0883
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.0522 0.1445
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0207 0.078
Brugia malayi conserved hypotetical protein 0.0032 0.0085 0.0121
Schistosoma mansoni hypothetical protein 0.0069 0.0224 0.0275
Brugia malayi beta-lactamase family protein 0.004 0.0116 0.0165
Schistosoma mansoni dishevelled 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0047 0.0141 0.0391
Trypanosoma brucei importin beta-1 subunit, putative 0.0092 0.031 0.1145
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.0085 0.0105
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.4926
Schistosoma mansoni hypothetical protein 0.0043 0.0126 0.0155
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0011 0.0011 0.003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0099 0.0122
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0067 0.0216 0.0597
Echinococcus granulosus neuropeptide receptor A26 0.0522 0.1897 0.233
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0114
Loa Loa (eye worm) hypothetical protein 0.0138 0.0479 0.1327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0216 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0203 0.0719 0.0883
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0219 0.0776 0.2147
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0011 0.0011 0.0013
Brugia malayi hypothetical protein 0.0158 0.0551 0.0784
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0116 0.4662
Onchocerca volvulus Bile acid receptor homolog 0.0067 0.0216 0.022
Brugia malayi ecdysteroid receptor 0.0067 0.0216 0.0307
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.0085 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0114
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0011 0.0011 0.0105
Schistosoma mansoni retinoic acid receptor RXR 0.0067 0.0216 0.0265
Brugia malayi aldehyde dehydrogenase 0.0011 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0219 0.0776 0.2147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0075 0.0246 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0066 0.2341
Brugia malayi steroid hormone receptor 0.0067 0.0216 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0037 0.0376
Loa Loa (eye worm) hypothetical protein 0.0188 0.0665 0.184
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0203 0.0719 0.1989
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0003 0.0004
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0011 0.0011 0.0105
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0011 0.0011 0.003
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0216 0.0265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0011 0.0011 0.0085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0067 0.0216 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0203 0.0719 0.0883
Echinococcus granulosus geminin 0.0543 0.1975 0.2427
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0011 0.0011 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0126 0.0155
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0141 0.0174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0126 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0085 0.0085
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0011 0.0011 0.0105
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0011 0.0011 0.0015
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0011 0.0011 0.0105
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0987 0.3614 1
Brugia malayi RNA binding protein 0.0203 0.0719 0.1022
Brugia malayi DIX domain containing protein 0.0009 0.0003 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0116 0.1245
Schistosoma mansoni survival motor neuron protein 0.0108 0.0368 0.0452
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0068 0.022 0.0721
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0275
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0011 0.0011 0.0683
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0216 0.0265
Onchocerca volvulus 0.0158 0.0551 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0522 0.0642
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0067 0.0216 0.0216
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0047 0.014
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0141 0.0141
Brugia malayi nuclear hormone receptor 0.0067 0.0216 0.0307
Toxoplasma gondii RNA-directed DNA polymerase 0.0719 0.2624 1
Brugia malayi hypothetical protein 0.0035 0.0099 0.0141
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0068 0.022 0.022
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0047 0.1822
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0047 0.0169
Trypanosoma brucei importin beta-1 subunit, putative 0.0092 0.031 0.1145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0037 0.0376
Echinococcus multilocularis tar DNA binding protein 0.0203 0.0719 0.0719
Brugia malayi nuclear receptor NHR-67 0.0032 0.0085 0.0121
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0003 0.0004
Brugia malayi nuclear hormone receptor family member odr-7 0.0032 0.0085 0.0121
Onchocerca volvulus 0.0108 0.0368 0.0377
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0216 0.0265
Schistosoma mansoni apoferritin-2 0.0009 0.0003 0.0004
Schistosoma mansoni dep domain containing protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0067 0.0216 0.0597
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0522 0.0642
Leishmania major telomerase reverse transcriptase, putative 0.0719 0.2624 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0479 0.1327
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0207 0.0735 0.806
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0011 0.0011 0.0105
Loa Loa (eye worm) hypothetical protein 0.0158 0.0551 0.1526
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0011 0.0011 0.0105
Leishmania major GTP-binding protein, putative 0.0068 0.022 0.08
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0182
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0047 0.0067
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0141 0.0174
Echinococcus granulosus cpg binding protein 0.0036 0.0102 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0236
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0165 0.0165
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.0649 0.0797
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0216 0.0307
Brugia malayi TAR-binding protein 0.0203 0.0719 0.1022
Echinococcus granulosus GPCR family 2 0.0069 0.0224 0.0275
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.021
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0011 0.0011 0.0085
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0719 0.2624 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0067 0.0216 0.0265
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0011 0.0011 0.003
Brugia malayi Importin beta-1 subunit 0.0092 0.031 0.0441
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0011 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0067 0.0216 0.0597
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0047 0.1822
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0207 0.0735 0.0903
Brugia malayi MH2 domain containing protein 0.0125 0.0429 0.061
Schistosoma mansoni tar DNA-binding protein 0.0203 0.0719 0.0883
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0067 0.0216 0.0265
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0116 0.1545
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.0522 0.0742
Onchocerca volvulus 0.0021 0.0047 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0011 0.0011 0.0085
Echinococcus multilocularis snurportin 1 0.0987 0.3614 0.3614
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0131
Plasmodium vivax hypothetical protein, conserved 0.004 0.0116 0.032
Schistosoma mansoni hypothetical protein 0.0284 0.1018 0.1251

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10 % Angiotensin II-like agonist activity, measured in the in vitro rabbit aorta strip assay ChEMBL. 2724307
pA2 (functional) = 0 Antagonist activity pA2, was measured in the in vitro rabbit aorta strip assay ChEMBL. 2724307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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