Detailed information for compound 401106

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1465.47 | Formula: C66H88N12O26
  • H donors: 22 H acceptors: 19 LogP: -6.35 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](Oc2ccc(cc2)C[C@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(NC(=O)[C@@H](NC2=O)[C@H]([C@@H]2CN=C(N2)N)O)C([C@@H]2CN=C(N2[C@H]2O[C@H](CO)[C@H]([C@@H]([C@@H]2O)O)O)N)O)CO)[C@H](c2ccccc2)C)[C@H]([C@H]([C@@H]1O[C@H]1O[C@H](COCc2ccc3c(c2)ccc(c3)OC)[C@H]([C@@H]([C@@H]1O)O)O)O)O
  • InChi: 1S/C66H88N12O26/c1-27(30-6-4-3-5-7-30)43-59(95)72-35(17-28-9-13-33(14-10-28)100-63-55(92)52(89)56(40(24-81)102-63)104-64-54(91)51(88)49(86)41(103-64)26-99-25-29-8-11-32-18-34(98-2)15-12-31(32)16-29)58(94)76-44(46(83)36-19-70-65(67)74-36)61(97)77-45(60(96)73-37(22-79)57(93)69-21-42(82)75-43)47(84)38-20-71-66(68)78(38)62-53(90)50(87)48(85)39(23-80)101-62/h3-16,18,27,35-41,43-56,62-64,79-81,83-92H,17,19-26H2,1-2H3,(H2,68,71)(H,69,93)(H,72,95)(H,73,96)(H,75,82)(H,76,94)(H,77,97)(H3,67,70,74)/t27-,35+,36-,37-,38-,39+,40+,41+,43-,44-,45?,46-,47?,48+,49+,50-,51-,52+,53-,54-,55-,56+,62-,63-,64+/m0/s1
  • InChiKey: NPXYNPUPFIIQCP-YNPJEPRGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0044 0.1322
Schistosoma mansoni z-protein (S1r protein) 0.002 0.001 0.0045
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.001 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0107 0.0177 0.1752
Brugia malayi hypoxia-induced factor 1 0.0156 0.0269 0.1881
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Loa Loa (eye worm) gastrulation defective protein 1 0.0135 0.0229 0.1224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0162 0.1072
Onchocerca volvulus 0.0037 0.0043 0.0705
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0185 0.0325 0.227
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0233 0.0416 0.4146
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0078 0.0477
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0053 0.0073 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.001 0.0007
Entamoeba histolytica protein kinase, putative 0.0053 0.0073 0.0442
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0035 0.0035
Toxoplasma gondii ck2 beta subunit 0.0038 0.0044 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0512 0.3538
Loa Loa (eye worm) phosphatidylinositol 3 0.0996 0.1871 1
Echinococcus granulosus protein kinase shaggy 0.0053 0.0073 0.0072
Toxoplasma gondii 6-phosphofructokinase 0.003 0.003 0.0328
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0554 0.1029 0.1028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0483 0.3334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0556 0.3845
Brugia malayi phosphofructokinase 0.0113 0.0187 0.1303
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0063 0.0092 0.0865
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0035 0.0035
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Brugia malayi hypothetical protein 0.002 0.001 0.0067
Entamoeba histolytica hypothetical protein 0.0107 0.0177 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus multilocularis lamin dm0 0.0028 0.0025 0.0024
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0283 0.0512 0.528
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.019 0.0334 0.228
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0028 0.0025 0.0025
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1122 0.211 0.211
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Echinococcus multilocularis regulator of G protein signaling 0.002 0.001 0.0009
Loa Loa (eye worm) RecQ helicase 0.0022 0.0014 0.0072
Schistosoma mansoni intermediate filament proteins 0.0028 0.0025 0.0116
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0315 0.0573 0.3964
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.019 0.0334 0.0333
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.0956
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0554 0.1029 0.1028
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0187 0.0186
Onchocerca volvulus 0.0099 0.0162 0.2663
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0242 0.1637
Leishmania major phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.0474
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0654
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0044 0.0725
Loa Loa (eye worm) phosphatidylinositol 3 0.0519 0.0961 0.5133
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0028 0.0025 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0657 0.1225 0.8558
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0054 0.0146
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0035 0.0035
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.001 0.0045
Leishmania major phosphatidylinositol kinase, putative 0.0107 0.0177 0.0474
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0311 0.0565 0.3909
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.0000000073565
Schistosoma mansoni hypothetical protein 0.0174 0.0304 0.1438
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.526 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0107 0.0177 0.0502
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0028 0.0025 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0236 0.1117
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0044 0.0118
Brugia malayi Protein kinase domain containing protein 0.0138 0.0236 0.1649
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0187 0.1245
Mycobacterium ulcerans putative regulatory protein 0.002 0.001 0.0007
Loa Loa (eye worm) phosphatidylinositol kinase 0.0107 0.0177 0.0943
Onchocerca volvulus 0.0028 0.0025 0.0403
Echinococcus multilocularis protein kinase shaggy 0.0053 0.0073 0.0072
Brugia malayi serine/threonine-protein kinase plk-2 0.0198 0.035 0.2449
Loa Loa (eye worm) calcium channel 0.0033 0.0035 0.0187
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.0502
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.019 0.0334 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.009 0.0143 0.0677
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0017 0.0016
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0519 0.0961 0.2618
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.0092 0.0257
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0764 0.1429 1
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0038 0.0044 0.0485
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0332 0.0606 0.0605
Echinococcus granulosus cyclin dependent kinase 19 0.0138 0.0236 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0315 0.0573 0.4004
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0017 0.0087
Echinococcus multilocularis musashi 0.0028 0.0025 0.0024
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.009 0.0143 0.0142
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.019 0.0334 0.1579
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0198 0.035 0.0948
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0364 0.0667 0.3158
Toxoplasma gondii hypothetical protein 0.002 0.001 0.0114
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0028 0.0025 0.0108
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0143
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Brugia malayi FAT domain containing protein 0.0189 0.0332 0.2318
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0519 0.0961 0.4551
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0332 0.0606 1
Toxoplasma gondii GAF domain-containing protein 0.002 0.001 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0053 0.0248
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0044 0.1096
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0509 0.0942 0.0942
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.019 0.0334 0.1781
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0509 0.0942 0.0942
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0177 0.1235
Schistosoma mansoni protein kinase 0.0142 0.0242 0.1146
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0107 0.0177 0.5296
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Leishmania major phosphatidylinositol 3-kinase, putative 0.0457 0.0843 0.2295
Echinococcus granulosus single minded 2 0.0037 0.0043 0.0043
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0014 0.0094
Echinococcus granulosus casein kinase ii subunit alpha 0.0142 0.0242 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0092 0.0582
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0073 0.0442
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Trypanosoma cruzi casein kinase II, putative 0.0142 0.0242 0.0691
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0177 0.9446
Onchocerca volvulus 0.0107 0.0177 0.2913
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0044 0.0243
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.001 0.0009
Schistosoma mansoni survival motor neuron protein 0.0099 0.0162 0.0764
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Plasmodium vivax hypothetical protein, conserved 0.002 0.001 0.0303
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.0888 0.6187
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0332 0.0606 0.0605
Plasmodium vivax SET domain protein, putative 0.0031 0.0031 0.0906
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0187 0.0882
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0315 0.0573 0.5917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0177 0.1176
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0043 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0107 0.0177 0.0836
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Onchocerca volvulus 0.0104 0.017 0.2806
Echinococcus multilocularis 0.0107 0.0177 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Entamoeba histolytica hypothetical protein 0.0107 0.0177 0.1176
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0891
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0107 0.0177 0.1932
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0315 0.0573 0.1649
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.5
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0053 0.0073 0.02
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0268 0.0483 0.0483
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0033 0.0035 0.0035
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.001 0.0045
Onchocerca volvulus 0.0243 0.0436 0.7194
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0142 0.0242 0.7262
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0031 0.0334
Entamoeba histolytica hypothetical protein 0.0639 0.119 0.8316
Echinococcus granulosus geminin 0.0174 0.0304 0.0303
Brugia malayi Pre-SET motif family protein 0.0214 0.038 0.2653
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0557 0.1033 0.7229
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0063 0.0092 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0961 0.6697
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0332 0.0606 0.3237
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0519 0.0961 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0332 0.0606 0.4238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0764 0.1429 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.0502
Echinococcus multilocularis geminin 0.0174 0.0304 0.0303
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0138 0.0236 0.126
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0092 0.0148 0.0148
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.0956
Brugia malayi 6-phosphofructokinase 0.0113 0.0187 0.1303
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0054 0.0312
Brugia malayi SH2 domain containing protein 0.0352 0.0643 0.4496
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0961 0.6697
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0063 0.0092 0.0092
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.009 0.0143 0.0142
Plasmodium falciparum phosphatidylinositol 3-kinase 0.019 0.0334 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0142 0.0242 0.7191
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0519 0.0961 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0025 0.0172
Schistosoma mansoni lamin 0.0028 0.0025 0.0116
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0028 0.0028
Echinococcus multilocularis serine protein kinase ATM 0.0283 0.0512 0.0512
Entamoeba histolytica casein kinase, putative 0.0142 0.0242 0.1637
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0315 0.0573 0.5917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus granulosus lamin dm0 0.0028 0.0025 0.0024
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0073 0.0458
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0198 0.035 0.035
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0145 0.0249 0.2514
Loa Loa (eye worm) hypothetical protein 0.0296 0.0536 0.2865
Entamoeba histolytica hypothetical protein 0.0107 0.0177 0.1176
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0187 1
Schistosoma mansoni hypothetical protein 0.0037 0.0043 0.0202
Echinococcus multilocularis cyclin dependent kinase 19 0.0138 0.0236 0.0236
Schistosoma mansoni voltage-gated cation channel 0.0033 0.0035 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.0888 0.6187
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0063 0.0092 0.0092
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0107 0.0177 0.0836
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.003 0.0328
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.019 0.0334 0.228
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0177 0.1235
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.001 0.0009
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1122 0.211 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Trypanosoma cruzi target of rapamycin kinase 3 0.05 0.0924 0.2668
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0279 0.0504 0.3483
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0509 0.0942 0.2719
Brugia malayi intermediate filament protein 0.0028 0.0025 0.0172
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0519 0.0961 0.2773
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0017 0.0087
Loa Loa (eye worm) hypothetical protein 0.0104 0.017 0.0909
Leishmania major phosphatidylinositol kinase related protein, putative 0.0123 0.0206 0.0553
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0177 0.5296
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0035 0.0035
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0073 0.0458
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0043 0.0043
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.0009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6122
Echinococcus multilocularis tumor protein p63 0.035 0.0639 0.0638
Echinococcus multilocularis high voltage activated calcium channel beta 0.009 0.0143 0.0143
Giardia lamblia Casein kinase II beta chain 0.0038 0.0044 0.0154
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0187 0.1245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0031 0.003
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0764 0.1429 0.4131
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0044 0.0243
Echinococcus multilocularis casein kinase ii subunit alpha 0.0142 0.0242 0.0242
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni hypothetical protein 0.0084 0.0133 0.0628
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0107 0.0177 0.0176
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.019 0.0334 0.228
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0187 1
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Echinococcus granulosus bloom syndrome protein 0.0022 0.0014 0.0013
Giardia lamblia GTOR 0.0519 0.0961 1
Schistosoma mansoni single-minded 0.005 0.0068 0.0321
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.003 0.0142
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.001 0.0053
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0033 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Plasmodium vivax unspecified product 0.0142 0.0242 0.7262
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.5296
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0076
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Giardia lamblia Phosphatidylinositol 4-kinase 0.0107 0.0177 0.1577
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0073 0.0442
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.0332 0.2266
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.001 0.0051
Giardia lamblia Kinase, CMGC CK2 0.0142 0.0242 0.2281
Giardia lamblia Kinase, PLK 0.0198 0.035 0.3442
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.1572 0.1572
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0092 0.0148 0.0699
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0028 0.0025 0.0117
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0073 0.0386
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0107 0.0177 0.1932
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0073 0.0442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0143
Loa Loa (eye worm) Csnk2b protein 0.0038 0.0044 0.0235
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0283 0.0512 0.1473
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Trypanosoma brucei target of rapamycin kinase 3, putative 0.05 0.0924 0.962
Brugia malayi 6-phosphofructokinase 0.0113 0.0187 0.1303
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.0092 0.0257
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0162 0.1129
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0053 0.0073 0.0072
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0033 0.0035 0.0165
Trypanosoma cruzi cytochrome P450, putative 0.002 0.001 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0339 0.0618 0.4283
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.0483 0.139
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0764 0.1429 0.4131
Echinococcus granulosus axis inhibition protein axin 0.002 0.001 0.0009
Toxoplasma gondii target of rapamycin (TOR), putative 0.0495 0.0915 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0519 0.0961 0.096
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.035 0.1658
Giardia lamblia Hypothetical protein 0.0107 0.0177 0.1577
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0043 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Echinococcus multilocularis axis inhibition protein axin 0.002 0.001 0.0009
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.1827 0.3454 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.037
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0187 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0043 0.1861
Schistosoma mansoni axis inhibition protein axin 0.002 0.001 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0177 0.1176
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.05 0.0924 0.2519
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0187 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0177 0.9446
Loa Loa (eye worm) hypothetical protein 0.0189 0.0332 0.1771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0468 0.0864 0.6016
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0509 0.0942 0.2719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0198 0.035 0.1871
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Entamoeba histolytica hypothetical protein 0.0283 0.0512 0.3538
Entamoeba histolytica protein kinase rad3, putative 0.0268 0.0483 0.3334
Echinococcus multilocularis expressed conserved protein 0.0084 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0126
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0189 0.0332 0.0331
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0187 0.05
Brugia malayi Casein kinase II, alpha chain 0.0142 0.0242 0.1693
Schistosoma mansoni fkbp-rapamycin associated protein 0.0268 0.0483 0.2288
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0457 0.0843 0.876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.0438 0.2342
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0572 0.1063 0.7418
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0891
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000034868
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0063 0.0092 0.0582
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.019 0.0334 0.2332
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0017 0.0113
Onchocerca volvulus 0.0107 0.0177 0.2913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0117 0.0117
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.001 0.0045
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.0269 0.1437
Echinococcus granulosus serine protein kinase ATM 0.0283 0.0512 0.0512
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Plasmodium vivax glycogen synthase kinase 3, putative 0.0053 0.0073 0.2171
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.001 0.0009
Toxoplasma gondii FATC domain-containing protein 0.0283 0.0512 0.5596
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.007 0.0328
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0187 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0296 0.0536 0.5861
Brugia malayi follicle stimulating hormone receptor 0.0245 0.0438 0.3066
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.003 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.001 0.0067
Schistosoma mansoni axis inhibition protein axin 0.002 0.001 0.0045
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0519 0.0961 0.2773
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0161
Brugia malayi Cytochrome P450 family protein 0.002 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.0488 0.0902 0.4818
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0187
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Brugia malayi hypothetical protein 0.0037 0.0043 0.0299
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0031 0.0162
Loa Loa (eye worm) hypothetical protein 0.0257 0.0462 0.2469
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0208 0.0368 0.1055
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0519 0.0961 0.096
Onchocerca volvulus Serine\/threonine kinase homolog 0.0198 0.035 0.5778
Echinococcus granulosus casein kinase ii subunit beta 0.0038 0.0044 0.0044
Brugia malayi hypothetical protein 0.002 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0176 0.0307 0.1641
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0187 0.0995
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0519 0.0961 0.2618
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0131
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.0902
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0053 0.0073 0.0794
Schistosoma mansoni hypothetical protein 0.0053 0.0073 0.0345
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.0902 0.0901
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0031 0.003
Toxoplasma gondii hypothetical protein 0.002 0.001 0.0114
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0187 0.1245
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0033 0.0035 0.0245
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0187 0.0882
Schistosoma mansoni hypothetical protein 0.0189 0.0332 0.157
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0107 0.0177 0.5174
Loa Loa (eye worm) hypothetical protein 0.0169 0.0294 0.157
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0005 0.0022
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.001 0.0067
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0044 0.0118
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0764 0.1429 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0382 0.07 0.4862
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0025 0.0131
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0028 0.0025 0.0108
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0107 0.0177 0.5174
Brugia malayi Serotonin receptor 0.0483 0.0892 0.6242
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0107 0.0177 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6122
Echinococcus multilocularis Zinc finger, PHD finger 0.019 0.0334 0.0333
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0315 0.0573 0.3964
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.003 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0519 0.0961 0.6697
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0519 0.0961 0.6719
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0176 0.0307 0.088
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0038 0.0044 0.0358
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0447 0.0824 0.8529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0483 0.3379
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0092 0.0148 0.0148
Brugia malayi M-phase phosphoprotein, mpp8 0.0104 0.017 0.119
Echinococcus granulosus axis inhibition protein axin 0.002 0.001 0.0009
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0468 0.0864 0.8982
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.001 0.0067
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0123 0.0206 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.0536 0.3709
Leishmania major casein kinase II, putative 0.0142 0.0242 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0556 0.3845
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0035 0.0035
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0107 0.0177 0.1932
Leishmania major phosphatidylinositol 3-kinase, putative 0.019 0.0334 0.0902
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Loa Loa (eye worm) hypothetical protein 0.0554 0.1029 0.5497
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.019 0.0334 0.228
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Leishmania major hypothetical protein, unknown function 0.0107 0.0177 0.0474
Onchocerca volvulus 0.0028 0.0025 0.0403
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.001 0.0009
Echinococcus multilocularis axis inhibition protein axin 0.002 0.001 0.0009
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0187 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0044 0.0725
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0315 0.0573 0.3964
Toxoplasma gondii hypothetical protein 0.0055 0.0078 0.0849
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Schistosoma mansoni hypothetical protein 0.0099 0.0162 0.0764
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.001 0.0067
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0063 0.0092 0.0865
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0357 0.0653 0.4566
Onchocerca volvulus 0.0053 0.0073 0.1193
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0038 0.0044 0.0111
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0028 0.0025 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0025 0.0131
Trypanosoma brucei polo-like protein kinase 0.0198 0.035 0.3578
Echinococcus granulosus tumor protein p63 0.035 0.0639 0.0638
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0107 0.0177 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0278 0.1892
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0073 0.0442
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0519 0.0961 0.6697
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Echinococcus multilocularis lamin 0.0028 0.0025 0.0024
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.0902 0.0901
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0107 0.0177 0.1176
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.0092 0.0257
Schistosoma mansoni kinase 0.0102 0.0167 0.0789
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0279 0.0504 0.3483
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0049 0.0066 0.0352
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0053 0.0073 0.0342
Brugia malayi PAS domain containing protein 0.005 0.0068 0.0474
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.0000000073565
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0035 0.0035
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0044 0.0243
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0028 0.0025 0.0174
Onchocerca volvulus 0.0051 0.007 0.1143
Loa Loa (eye worm) hypothetical protein 0.0268 0.0483 0.2581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1122 0.211 0.211
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0198 0.035 0.035
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.019 0.0334 0.3645
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0042
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0053 0.0073 0.0189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0027
Echinococcus granulosus high voltage activated calcium channel beta 0.009 0.0143 0.0143
Echinococcus granulosus intermediate filament protein 0.0028 0.0025 0.0024
Echinococcus granulosus expressed protein 0.0386 0.0709 0.0708
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0117 0.0117
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0107 0.0177 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0004
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0073 0.0386
Mycobacterium ulcerans putative regulatory protein 0.002 0.001 0.0007
Echinococcus multilocularis casein kinase ii subunit beta 0.0038 0.0044 0.0044
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0509 0.0942 0.4463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0961 0.6697
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0033 0.0035 0.0035
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0185 0.0325 0.1734
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0142 0.0242 0.1293
Brugia malayi Csnk2b protein 0.0038 0.0044 0.0308
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0187 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.033 0.0601 0.4165
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0283 0.0512 0.2425
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.035 0.1004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0362 0.0662 0.4595
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0315 0.0573 0.3964
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.1752
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Brugia malayi Protein kinase domain containing protein 0.0332 0.0606 0.4238
Brugia malayi hypothetical protein 0.0169 0.0294 0.2056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0509 0.0942 0.6589
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0014 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0468 0.0864 0.2353
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0187 0.1855
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0054
Trypanosoma cruzi cytochrome P450, putative 0.002 0.001 0.0019
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0187 0.0995
Echinococcus granulosus lamin 0.0028 0.0025 0.0024
Leishmania major cytochrome p450-like protein 0.002 0.001 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0078 0.0477
Loa Loa (eye worm) hypothetical protein 0.0352 0.0643 0.3434
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.001 0.0067
Trypanosoma brucei Casein kinase II 0.0142 0.0242 0.2441
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0043 0.0299
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Onchocerca volvulus 0.0104 0.017 0.2806
Schistosoma mansoni phosphatidylinositol 4-kinase 0.019 0.0334 0.1579
Brugia malayi Cytochrome P450 family protein 0.0031 0.0031 0.0212
Schistosoma mansoni hypothetical protein 0.0107 0.0177 0.0836
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0014 0.0013
Echinococcus multilocularis expressed protein 0.0386 0.0709 0.0708
Plasmodium vivax hypothetical protein 0.0107 0.0177 0.5296
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0764 0.1429 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0268 0.0483 0.0483
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.035 0.1004
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0033 0.0035 0.0165
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.0009
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0017 0.0016
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0572 0.1063 0.7418
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0043 0.0202
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.3401
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0044 0.1096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0556 0.3845
Echinococcus granulosus expressed conserved protein 0.0084 0.0133 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0512 0.3581
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.019 0.0334 0.0333
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.5296
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0014 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0764 0.1429 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.001 0.0053
Brugia malayi Pre-SET motif family protein 0.0031 0.0031 0.0211
Brugia malayi Protein kinase domain containing protein 0.0018 0.0007 0.0047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0639 0.119 0.8316
Toxoplasma gondii CMGC kinase, CK2 family 0.0142 0.0242 0.2648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0044 0.1322
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0092 0.0148 0.0699
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0013 0.0066
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0068 0.0321
Plasmodium falciparum glycogen synthase kinase 3 0.0053 0.0073 0.1967
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni hypothetical protein 0.0174 0.0304 0.1438
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.038 0.2027
Schistosoma mansoni lamin 0.0028 0.0025 0.0116
Loa Loa (eye worm) RGS-3 protein 0.002 0.001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0104 0.0171 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0078 0.0477
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.0278 0.1892
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0332 0.0606 0.3237
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0054 0.0312
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0086
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0107 0.0177 0.1176
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0606 0.287
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Brugia malayi hypothetical protein 0.0488 0.0902 0.6307
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.019 0.0334 0.0333
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.001 0.0051
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.019 0.0334 0.3645
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0189 0.0332 0.0331
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0864 0.4616
Trypanosoma brucei protein kinase, putative 0.0053 0.0073 0.0656
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0086
Brugia malayi Cytochrome P450 family protein 0.002 0.001 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Loa Loa (eye worm) phosphatidylinositol 3 0.0208 0.0368 0.1965
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Leishmania major hypothetical protein, conserved 0.1934 0.3659 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.019 0.0334 0.228
Loa Loa (eye worm) CYP4Cod1 0.002 0.001 0.0053
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0436 0.3
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0031 0.003
Schistosoma mansoni casein kinase II beta subunit 0.0038 0.0044 0.0208
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0177 0.1235
Onchocerca volvulus 0.0042 0.0053 0.0865
Brugia malayi hypothetical protein 0.0104 0.0171 0.1191
Entamoeba histolytica serine/threonine protein kinase, putative 0.0198 0.035 0.2398
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0162 0.1072
Brugia malayi intracellular kinase 0.0053 0.0073 0.0506
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0107 0.0177 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0213 0.143

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) <= 0.06 ug ml-1 In vitro minimum inhibitory concentration of the compound against Streptococcus species; ChEMBL. 12873519
MIC (functional) = 1 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus aureus; 1-2 ChEMBL. 12873519
MIC (functional) = 2 ug ml-1 In vitro minimum inhibitory concentration of the compound against Enterococcus species 2-8 ChEMBL. 12873519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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