Detailed information for compound 401332

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2315.59 | Formula: C104H147N29O28S2
  • H donors: 30 H acceptors: 28 LogP: -3.22 Rotable bonds: 57
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC[C@@H]([C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N)CCC(=O)O)C(C)C)Cc1ccccc1)CCC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)Nc1cccc(c1)C)C)CC(C)C)C
  • InChi: 1S/C104H147N29O28S2/c1-9-54(7)84-100(159)127-72(46-82(142)143)93(152)118-63(25-16-36-112-102(108)109)87(146)125-70(43-58-47-114-62-24-14-13-23-61(58)62)92(151)124-68(42-57-28-30-60(134)31-29-57)91(150)130-74(96(155)119-66(32-34-77(105)135)88(147)123-69(41-56-20-11-10-12-21-56)95(154)131-83(52(4)5)99(158)121-65(33-35-80(138)139)86(145)115-48-79(107)137)49-162-163-50-75(129-90(149)67(39-51(2)3)122-85(144)55(8)116-104(161)117-59-22-15-19-53(6)40-59)97(156)126-71(45-81(140)141)94(153)128-73(44-78(106)136)101(160)133-38-18-27-76(133)98(157)120-64(89(148)132-84)26-17-37-113-103(110)111/h10-15,19-24,28-31,40,47,51-52,54-55,63-76,83-84,114,134H,9,16-18,25-27,32-39,41-46,48-50H2,1-8H3,(H2,105,135)(H2,106,136)(H2,107,137)(H,115,145)(H,118,152)(H,119,155)(H,120,157)(H,121,158)(H,122,144)(H,123,147)(H,124,151)(H,125,146)(H,126,156)(H,127,159)(H,128,153)(H,129,149)(H,130,150)(H,131,154)(H,132,148)(H,138,139)(H,140,141)(H,142,143)(H4,108,109,112)(H4,110,111,113)(H2,116,117,161)/t54-,55-,63+,64-,65-,66-,67-,68+,69-,70-,71+,72-,73-,74+,75+,76+,83-,84+/m0/s1
  • InChiKey: OQHMQQKPMNGVFR-IOJUSPAISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus glycoprotein Antigen 5 coagulation factor VII (serum prothrombin conversion accelerator) 466 aa 384 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0127 0.1064
Plasmodium falciparum GAF domain-related protein, putative 0.0022 0.0009 0.0041
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0721 0.0843 0.746
Brugia malayi hypothetical protein 0.0525 0.0609 0.5394
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0731 0.0855 0.972
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.0855 0.7562
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0127 0.1064
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0168 0.1964
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0046 0.0038 0.0266
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0041 0.0032 0.0353
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0751 0.0879 0.5193
Echinococcus granulosus expressed protein 0.0416 0.0479 0.0479
Leishmania major cytochrome p450-like protein 0.0022 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0155 0.0168 0.0983
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0008 0.0008
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0168 0.0168
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0008 0.0057
Entamoeba histolytica protein kinase domain containing protein 0.0153 0.0165 0.1399
Entamoeba histolytica hypothetical protein 0.004 0.0031 0.02
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0008 0.0008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0111 0.0916
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis Ankyrin 0.0016 0.0002 0.0002
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0051 0.0288
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0698 0.0816 0.0816
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.004 0.0031 0.02
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.0286 0.2477
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0011 0.0081
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0478 0.4231
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.0473
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0415 0.0478 0.5393
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0002 0.000000029333
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.096 0.1128 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0751 0.0879 0.5839
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0022 0.0121
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0025 0.0025
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0022 0.0516
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0214 0.0238 0.0238
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0149 0.0161 0.1067
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0098 0.0098
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0013 0.0085
Echinococcus multilocularis lamin 0.003 0.0018 0.0018
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0064 0.0636
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0025 0.0025
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0022 0.0239
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Brugia malayi serine/threonine-protein kinase plk-2 0.0214 0.0238 0.2095
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0538 0.4733
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0064 0.0064
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0032 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0002 0.0002
Leishmania major phosphatidylinositol 3-kinase, putative 0.0254 0.0286 0.0771
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0168 0.0473
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0013 0.0013
Echinococcus granulosus high voltage activated calcium channel beta 0.0097 0.0098 0.0098
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0019 0.0092
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Leishmania major phosphatidylinositol kinase related protein, putative 0.0171 0.0187 0.0502
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0127 0.1364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0022 0.012
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Onchocerca volvulus 0.0107 0.0111 0.2662
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0254 0.0286 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.0274 0.237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0751 0.0879 0.7781
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0058
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0011 0.0024
Echinococcus granulosus lamin dm0 0.003 0.0018 0.0018
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0415 0.0478 0.1368
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0002 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0286 0.1898
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1115
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0168 0.1426
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0008 0.0008
Echinococcus multilocularis casein kinase ii subunit alpha 0.0153 0.0165 0.0165
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.003 0.0019 0.0149
Onchocerca volvulus 0.0057 0.0051 0.1193
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0127 0.0742
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.0471 0.4134
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0002 0.0013
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.8395 1 1
Schistosoma mansoni hypothetical protein 0.0187 0.0206 0.1209
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0127 0.0127
Loa Loa (eye worm) intermediate filament protein 0.003 0.0018 0.0122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0168 0.1475
Loa Loa (eye worm) Csnk2b protein 0.0041 0.0032 0.021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0741 0.0867 0.5119
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0122
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0804 0.0943 0.8346
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Onchocerca volvulus 0.0046 0.0037 0.0865
Schistosoma mansoni voltage-gated cation channel 0.0036 0.0025 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0399 0.0459 0.0459
Loa Loa (eye worm) phosphatidylinositol 3 0.1277 0.1506 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0051 0.0336
Onchocerca volvulus 0.0155 0.0168 0.4068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Schistosoma mansoni hypothetical protein 0.0057 0.0051 0.029
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0025 0.0025
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0214 0.0238 0.0238
Brugia malayi Death domain containing protein 0.0016 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0286 0.0324 0.282
Toxoplasma gondii hypothetical protein 0.006 0.0054 0.0618
Brugia malayi Csnk2b protein 0.0041 0.0032 0.0264
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0008 0.0038
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0038
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0127 0.0356
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0168 0.183
Brugia malayi hypothetical protein 0.0182 0.02 0.1759
Onchocerca volvulus 0.0262 0.0295 0.719
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.003 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0111 0.0916
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0031 0.0031
Echinococcus multilocularis Zinc finger, PHD finger 0.0254 0.0286 0.0286
Onchocerca volvulus 0.003 0.0018 0.0403
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1432 0.1692 0.1692
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Entamoeba histolytica casein kinase, putative 0.0153 0.0165 0.1399
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0019 0.0149
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0721 0.0843 0.746
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0399 0.0459 0.4058
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis casein kinase ii subunit beta 0.0041 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0025 0.0169
Brugia malayi Uncoordinated protein 44 0.0016 0.0002 0.0001
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0008 0.0008
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0051 0.1719
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0022 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0751 0.0879 0.7781
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.041 0.2415
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0409 0.0471 0.1348
Plasmodium vivax hypothetical protein 0.0155 0.0168 0.5854
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0127 0.0338
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0022 0.0121
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0051 0.0378
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0254 0.0286 1
Plasmodium vivax unspecified product 0.0153 0.0165 0.5749
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0041 0.0032 0.0075
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.096 0.1128 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0101 0.0588
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0051 0.0335
Echinococcus multilocularis musashi 0.003 0.0018 0.0018
Echinococcus granulosus cyclin dependent kinase 19 0.0149 0.0161 0.0161
Echinococcus granulosus protein kinase shaggy 0.0057 0.0051 0.0051
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0008 0.0008
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Onchocerca volvulus Serine\/threonine kinase homolog 0.0214 0.0238 0.5778
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.0473
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0025 0.0025
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0008 0.0008
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0127 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.0183 0.1216
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0013 0.0085
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0441 0.0509 0.4474
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0358 0.041 0.2723
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.096 0.1128 0.3244
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0008 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.7289
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0064 0.0173
Schistosoma mansoni survival motor neuron protein 0.0107 0.0111 0.0643
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0051 0.0335
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0036 0.0025 0.0025
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0038
Trypanosoma cruzi target of rapamycin kinase 3 0.0731 0.0855 0.2456
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0168 0.1704
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Loa Loa (eye worm) hypothetical protein 0.0379 0.0435 0.2888
Onchocerca volvulus 0.004 0.0031 0.0705
Brugia malayi bHLH-PAS transcription factor 0.004 0.0031 0.0256
Loa Loa (eye worm) phosphatidylinositol 3 0.0697 0.0814 0.5406
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0022 0.012
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0441 0.0509 0.3381
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0168 0.1426
Brugia malayi 6-phosphofructokinase 0.0121 0.0127 0.1115
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0036 0.0025 0.0025
Trypanosoma brucei protein kinase, putative 0.0057 0.0051 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.0855 0.7562
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0741 0.0867 0.249
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.003 0.0019 0.0019
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0013 0.0097
Onchocerca volvulus 0.0112 0.0116 0.2804
Echinococcus multilocularis tumor protein p63 0.0377 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0031 0.0031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0751 0.0879 0.2526
Brugia malayi PAS domain containing protein 0.0054 0.0048 0.0405
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0002 0.0002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0022 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0168 0.1426
Leishmania major hypothetical protein, unknown function 0.0155 0.0168 0.0449
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0011 0.0024
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1115
Echinococcus multilocularis expressed conserved protein 0.0091 0.0091 0.0091
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0022 0.0121
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0127 0.0846
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0032 0.0207
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0032 0.0079
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.0449
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0022 0.0706
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.096 0.1128 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0741 0.0867 0.0867
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0254 0.0286 0.0813
Echinococcus granulosus intermediate filament protein 0.003 0.0018 0.0018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0019 0.0092
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0022 0.0516
Brugia malayi SH2 domain containing protein 0.0379 0.0435 0.3847
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0168 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.0473 0.4151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0445 0.0514 0.4515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0741 0.0867 0.7682
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0064 0.0636
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis high voltage activated calcium channel beta 0.0097 0.0098 0.0098
Giardia lamblia Casein kinase II beta chain 0.0041 0.0032 0.0113
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0254 0.0286 0.0286
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0168 0.0983
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0037 0.0209
Toxoplasma gondii FATC domain-containing protein 0.0415 0.0478 0.5626
Loa Loa (eye worm) hypothetical protein 0.0525 0.0609 0.4045
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.1061 0.1061
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0196 0.0217 0.2391
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0127 0.7453
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0168 0.5854
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0099 0.0101 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0009 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0685 0.08 0.7071
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0064 0.0497
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1432 0.1692 0.1692
Toxoplasma gondii GAF domain-containing protein 0.0022 0.0009 0.0083
Leishmania major phosphatidylinositol 3-kinase, putative 0.0685 0.08 0.2181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0254 0.0286 0.0286
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0153 0.0165 0.1095
Loa Loa (eye worm) gastrulation defective protein 1 0.0145 0.0156 0.1038
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0064 0.0173
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0254 0.0286 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0399 0.0459 0.0459
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0171 0.0187 0.0529
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Entamoeba histolytica hypothetical protein 0.004 0.0031 0.02
Onchocerca volvulus 0.0155 0.0168 0.4068
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0168 0.0983
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0036 0.0025 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0002 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0701 0.0819 0.7256
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0127 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0022 0.0121
Schistosoma mansoni intermediate filament proteins 0.003 0.0018 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.071 0.0831 0.7345
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0168 0.1115
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0051 0.0378
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Loa Loa (eye worm) hypothetical protein 0.0112 0.0116 0.0773
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0153 0.0165 0.5749
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0697 0.0814 0.222
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Echinococcus multilocularis cyclin dependent kinase 19 0.0149 0.0161 0.0161
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0168 0.1964
Trypanosoma cruzi casein kinase II, putative 0.0153 0.0165 0.0464
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0031 0.017
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0038
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0698 0.0816 0.0816
Echinococcus multilocularis expressed protein 0.0416 0.0479 0.0479
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0168 0.0983
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0022 0.0022
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0411 0.0473 0.4151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.0814 0.7199
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0751 0.0879 0.0879
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0508 0.446
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0741 0.0867 0.0867
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0199 0.0221 0.1464
Giardia lamblia GTOR 0.0751 0.0879 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0286 0.0324 0.0324
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0022 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0051 0.0378
Brugia malayi Protein kinase domain containing protein 0.0358 0.041 0.3625
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0025 0.0025
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0008 0.0008
Brugia malayi FAT domain containing protein 0.0286 0.0324 0.2861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0168 0.1475
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0022 0.0239
Entamoeba histolytica hypothetical protein 0.0804 0.0942 0.8343
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.0286 0.2477
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0022 0.0243
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0127 0.1064
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0254 0.0286 0.252
Entamoeba histolytica hypothetical protein 0.0415 0.0478 0.4197
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0127 0.0846
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0036 0.0025 0.0139
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0286 0.3352
Toxoplasma gondii ck2 beta subunit 0.0041 0.0032 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0127 0.1064
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0751 0.0879 0.7781
Entamoeba histolytica serine/threonine protein kinase, putative 0.0214 0.0238 0.205
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0009 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0685 0.08 0.7071
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0009 0.0057
Entamoeba histolytica hypothetical protein 0.0155 0.0168 0.1426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0409 0.0471 0.4167
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0168 0.0473
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0409 0.0471 0.5311
Brugia malayi Serotonin receptor 0.052 0.0603 0.534
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0358 0.041 0.3625
Brugia malayi M-phase phosphoprotein, mpp8 0.0112 0.0116 0.1017
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0099 0.0101 0.0101
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0008 0.0008
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0018 0.0147
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.0812
Entamoeba histolytica hypothetical protein 0.004 0.0031 0.02
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0409 0.0471 0.4134
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0054 0.0408
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0107 0.0111 0.0643
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0008 0.0057
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0462 0.0534 0.6029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0051 0.0127
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0127 0.1064
Echinococcus multilocularis lamin dm0 0.003 0.0018 0.0018
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0008 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0009 0.0013
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0008 0.0057
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0168 0.5769
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0168 0.5769
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0036 0.0025 0.0025
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.5854
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0238 0.0674
Brugia malayi 6-phosphofructokinase 0.0121 0.0127 0.1115
Echinococcus multilocularis geminin 0.0187 0.0206 0.0206
Entamoeba histolytica hypothetical protein 0.0155 0.0168 0.1426
Brugia malayi intracellular kinase 0.0057 0.0051 0.0433
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.729
Brugia malayi Cytochrome P450 family protein 0.0033 0.0022 0.0182
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0022 0.0009 0.0007
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.5854
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0214 0.0238 0.064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0751 0.0879 0.7794
Schistosoma mansoni lamin 0.003 0.0018 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0274 0.237
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0022 0.0121
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.0297 0.1973
Loa Loa (eye worm) hypothetical protein 0.0312 0.0355 0.2358
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0751 0.0879 0.7781
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0254 0.0286 0.1679
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0032 0.0725
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0038
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0032 0.0863
Brugia malayi hypoxia-induced factor 1 0.0168 0.0183 0.1609
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0238 0.1396
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0751 0.0879 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0751 0.0879 0.7781
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0473 0.0547 0.4838
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0019 0.0092
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0018 0.0122
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0127 0.0846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.7289
Giardia lamblia Kinase, CMGC CK2 0.0153 0.0165 0.1669
Loa Loa (eye worm) hypothetical protein 0.0698 0.0816 0.5417
Brugia malayi Pre-SET motif family protein 0.023 0.0257 0.2268
Plasmodium vivax SET domain protein, putative 0.0033 0.0022 0.0717
Echinococcus granulosus serine protein kinase ATM 0.0415 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0035
Toxoplasma gondii hypothetical protein 0.0022 0.0009 0.0083
Echinococcus granulosus casein kinase ii subunit beta 0.0041 0.0032 0.0032
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.096 0.1128 1
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Schistosoma mansoni hypothetical protein 0.0286 0.0324 0.1906
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0751 0.0879 0.2398
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0022 0.0121
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0002 0.0013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0566 0.0658 0.7418
Echinococcus granulosus survival motor neuron protein 1 0.0525 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Giardia lamblia Hypothetical protein 0.0155 0.0168 0.1704
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0168 0.1964
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0358 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0009 0.0003
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0751 0.0879 0.2526
Brugia malayi Pre-SET motif family protein 0.0033 0.0022 0.018
Brugia malayi Cytochrome P450 family protein 0.0022 0.0009 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.7289
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0409 0.0471 0.4134
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0311 0.0353 0.3866
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0022 0.0121
Toxoplasma gondii target of rapamycin (TOR), putative 0.0726 0.0849 1
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0008 0.0038
Onchocerca volvulus 0.0055 0.0049 0.1143
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0168 0.0449
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0038
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0176 0.0192 0.1644
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0399 0.0459 0.1312
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0051 0.0051
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0008 0.0057
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0032 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0459 0.4023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0168 1
Brugia malayi hypothetical protein 0.004 0.0031 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0009 0.0241
Schistosoma mansoni protein kinase 0.0153 0.0165 0.0965
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0008 0.0008
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.2921 0.3468 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0064 0.0173
Loa Loa (eye worm) hypothetical protein 0.0055 0.0049 0.0323
Mycobacterium ulcerans putative regulatory protein 0.004 0.0031 0.1861
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0022 0.0148
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0751 0.0879 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0254 0.0286 0.2477
Leishmania major casein kinase II, putative 0.0153 0.0165 0.0441
Loa Loa (eye worm) hypothetical protein 0.0033 0.0022 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.071 0.0831 0.7345
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0697 0.0814 0.9251
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0254 0.0286 0.2477
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Entamoeba histolytica protein kinase rad3, putative 0.0399 0.0459 0.4023
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0254 0.0286 0.1679
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0358 0.041 0.2723
Schistosoma mansoni hypothetical protein 0.0091 0.0091 0.0529
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0238 0.0674
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0685 0.08 0.9088
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0168 0.5854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.0855 0.7562
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0008 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.0855 0.7562
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.183
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.729
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.0257 0.1708
Toxoplasma gondii hypothetical protein 0.0022 0.0009 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0214 0.0238 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0685 0.08 0.7071
Brugia malayi PXA domain containing protein 0.0023 0.001 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0508 0.446
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0054 0.0408
Loa Loa (eye worm) hypothetical protein 0.0182 0.02 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.0478 0.4197
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0032 0.0207
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0046 0.0038 0.0266
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0041 0.0032 0.0264
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0286 0.0324 0.0324
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0002 0.0002
Trypanosoma brucei Casein kinase II 0.0153 0.0165 0.1796
Onchocerca volvulus 0.003 0.0018 0.0403
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0008 0.0055
Brugia malayi hypothetical protein 0.0112 0.0117 0.1018
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0051 0.0578
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0111 0.0965
Brugia malayi Protein kinase domain containing protein 0.0149 0.0161 0.1411
Loa Loa (eye worm) hypothetical protein 0.0155 0.0168 0.1115
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0032 0.0207
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0127 0.0127
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0127 0.1064
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.0038 0.0098
Onchocerca volvulus 0.0112 0.0116 0.2804
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.0812
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.0771
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0286 0.0324 0.2151
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0022 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.729
Brugia malayi PXA domain containing protein 0.0023 0.001 0.0074
Entamoeba histolytica protein kinase, putative 0.0057 0.0051 0.0378
Brugia malayi hypothetical protein 0.0021 0.0008 0.0057
Plasmodium falciparum casein kinase 2, alpha subunit 0.0153 0.0165 0.5662
Brugia malayi follicle stimulating hormone receptor 0.0263 0.0297 0.2623
Leishmania major hypothetical protein, conserved 0.3076 0.3653 1
Brugia malayi Casein kinase II, alpha chain 0.0153 0.0165 0.1449
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0286 0.3352
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0031 0.0031
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0032 0.1047
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1115
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0008 0.0055
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0013 0.0013
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0751 0.0879 0.0879
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0025 0.0025
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0254 0.0286 0.1896
Brugia malayi phosphofructokinase 0.0121 0.0127 0.1115
Echinococcus granulosus bloom syndrome protein 0.0024 0.0011 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0492 0.057 0.5017
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0127 0.1064
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0022 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.096 0.1128 0.3244
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0254 0.0286 0.2477
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0358 0.041 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0051 0.0134
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0199 0.0221 0.1942
Brugia malayi Protein kinase domain containing protein 0.002 0.0006 0.0041
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0804 0.0942 0.8343
Entamoeba histolytica hypothetical protein 0.0155 0.0168 0.1426
Echinococcus multilocularis survival motor neuron protein 1 0.0525 0.0609 0.0609
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0032 0.0863
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0048 0.027
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.001 0.0068
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0101 0.0588
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0127 0.0742
Loa Loa (eye worm) RecQ helicase 0.0024 0.0011 0.0073
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.096 0.1128 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0022 0.0022
Echinococcus granulosus expressed conserved protein 0.0091 0.0091 0.0091
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0409 0.0471 0.4134
Loa Loa (eye worm) hypothetical protein 0.0399 0.0459 0.3046
Loa Loa (eye worm) hypothetical protein 0.026 0.0293 0.1946
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.3181
Toxoplasma gondii CMGC kinase, CK2 family 0.0153 0.0165 0.1928
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0022 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0508 0.446
Echinococcus granulosus geminin 0.0187 0.0206 0.0206
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0731 0.0855 0.2332
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0068 0.0064 0.0367
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.026 0.0293 0.0834
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0462 0.0535 0.3152
Echinococcus multilocularis serine protein kinase ATM 0.0415 0.0478 0.0478
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0161 0.094
Loa Loa (eye worm) calcium channel 0.0036 0.0025 0.0169
Trypanosoma brucei polo-like protein kinase 0.0214 0.0238 0.2632
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0168 0.1426
Schistosoma mansoni casein kinase II beta subunit 0.0041 0.0032 0.0175
Echinococcus multilocularis 0.0155 0.0168 0.0168
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0415 0.0478 0.2819
Schistosoma mansoni fkbp-rapamycin associated protein 0.0399 0.0459 0.2703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.0855 0.7562
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0751 0.0879 0.2398
Echinococcus granulosus Ankyrin 0.0016 0.0002 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1115
Echinococcus granulosus single minded 2 0.004 0.0031 0.0031
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0009 0.0057
Loa Loa (eye worm) hypothetical protein 0.0112 0.0117 0.0774
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0238 0.205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0022 0.0022
Brugia malayi intermediate filament protein 0.003 0.0018 0.0147
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0054 0.0408
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.046 0.0531 0.4673
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0008 0.0008
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0009 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0168 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0064 0.0497
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0008 0.0038
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0685 0.08 0.7071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0168 0.1426
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0002 0.0001
Schistosoma mansoni single-minded 0.0054 0.0048 0.027
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0036 0.0025 0.0139
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0032 0.0725
Echinococcus granulosus tumor protein p63 0.0377 0.0432 0.0432
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0008 0.0008
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0053 0.0046 0.0307
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0051 0.0378
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0051 0.0336
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0741 0.0867 0.249
Brugia malayi Cytochrome P450 family protein 0.0022 0.0009 0.006
Schistosoma mansoni lamin 0.003 0.0018 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0824 0.729
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0165 0.1399
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0064 0.0497
Schistosoma mansoni kinase 0.011 0.0114 0.0664
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0441 0.0509 0.5991
Brugia malayi hypothetical protein 0.0021 0.0008 0.0057
Echinococcus granulosus casein kinase ii subunit alpha 0.0153 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0187 0.0206 0.1209
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0127 0.7453
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0051 0.1549
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0008 0.0038
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0032 0.1047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0097 0.0098 0.057
Echinococcus granulosus lamin 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0564 0.4965
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0081 0.0081
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0358 0.041 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0849 0.7507
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1432 0.1692 1
Echinococcus granulosus death domain containing protein 0.0016 0.0002 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0262 0.0295 0.2563
Giardia lamblia Kinase, PLK 0.0214 0.0238 0.2518
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0048
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0051 0.0051
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.003 0.0019 0.0099
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0049 0.0276

Activities

Activity type Activity value Assay description Source Reference
Binding affinity (binding) = 0.59 In vitro binding affinity for human serum albumin. ChEMBL. 12270169
Binding affinity (binding) = 0.83 In vitro binding affinity for rabbit serum albumin. ChEMBL. 12270169
Binding affinity (binding) = 0.59 In vitro binding affinity for human serum albumin. ChEMBL. 12270169
Binding affinity (binding) = 0.83 In vitro binding affinity for rabbit serum albumin. ChEMBL. 12270169
IC50 (binding) = 1.8 nM Inhibition of amino terminally biotinylated E-76 peptide binding to immobilized fVIIa ChEMBL. 12270169
IC50 (binding) = 1.8 nM Inhibition of amino terminally biotinylated E-76 peptide binding to immobilized fVIIa ChEMBL. 12270169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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