Detailed information for compound 401392

Basic information

Technical information
  • TDR Targets ID: 401392
  • Name: (2S,5R,8S,11R,14S)-8-[(S)-[(5S)-2-amino-4,5-d ihydro-1H-imidazol-5-yl]-hydroxymethyl]-5-[(R )-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-tri hydroxy-6-(hydroxymethyl)oxan-2-yl]-4,5-dihyd roimidazol-4-yl]-hydroxymethyl]-11-[[4-[(2R,3 S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy -6-(hydroxymethyl)-5-[(6-methoxynaphthalen-2- yl)methoxy]oxan-2-yl]oxy-3,4-dihydroxy-6-(hyd roxymethyl)oxan-2-yl]oxyphenyl]methyl]-2-(hyd roxymethyl)-14-[(1S)-1-phenylethyl]-3,6,9,12, 15,18-hexazacyclooctadecane-1,4,7,10,13,16-he xone
  • MW: 1465.47 | Formula: C66H88N12O26
  • H donors: 22 H acceptors: 19 LogP: -6.35 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](Oc2ccc(cc2)C[C@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC2=O)[C@H]([C@@H]2CN=C(N2)N)O)[C@H]([C@@H]2CN=C(N2[C@H]2O[C@H](CO)[C@H]([C@@H]([C@@H]2O)O)O)N)O)CO)[C@H](c2ccccc2)C)[C@H]([C@H]([C@@H]1O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@@H]1O)O)OCc1ccc2c(c1)ccc(c2)OC)O)O
  • InChi: 1S/C66H88N12O26/c1-27(30-6-4-3-5-7-30)43-59(95)72-35(17-28-9-13-33(14-10-28)100-63-54(92)51(89)56(41(25-82)103-63)104-64-53(91)50(88)55(40(24-81)102-64)99-26-29-8-11-32-18-34(98-2)15-12-31(32)16-29)58(94)76-44(46(84)36-19-70-65(67)74-36)61(97)77-45(60(96)73-37(22-79)57(93)69-21-42(83)75-43)47(85)38-20-71-66(68)78(38)62-52(90)49(87)48(86)39(23-80)101-62/h3-16,18,27,35-41,43-56,62-64,79-82,84-92H,17,19-26H2,1-2H3,(H2,68,71)(H,69,93)(H,72,95)(H,73,96)(H,75,83)(H,76,94)(H,77,97)(H3,67,70,74)/t27-,35+,36-,37-,38-,39+,40+,41+,43-,44-,45+,46-,47-,48+,49-,50+,51+,52-,53-,54-,55+,56+,62-,63-,64+/m0/s1
  • InChiKey: NEXLBIOXHRMJKE-UQDBEIBASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S,5R,8S,11R,14S)-8-[(S)-[(5S)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-hydroxy-methyl]-5-[(R)-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-4,5-dihydroimidazol-4-yl]-hydroxy-methyl]-11-[[4-[(2R,3S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(6-methoxy-2-naphthyl)methoxy]tetrahydropyran-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyphenyl]methyl]-2-(hydroxymethyl)-14-[(1S)-1-phenylethyl]-3,6,9,12,15,18-hexazacyclooctadecane-1,4,7,10,13,16-hexone
  • (2S,5R,8S,11R,14S)-8-[(S)-[(5S)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-hydroxymethyl]-5-[(R)-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-4,5-dihydroimidazol-4-yl]-hydroxymethyl]-11-[[4-[[(2R,3S,4R,5S,6R)-5-[[(2R,3S,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(6-methoxy-2-naphthyl)methoxy]-2-tetrahydropyranyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]methyl]-2-(hydroxymethyl)-14-[(1S)-1-phenylethyl]-3,6,9,12,15,18-hexazacyclooctadecane-1,4,7,10,13,16-hexone
  • (2S,5R,8S,11R,14S)-8-[(S)-[(5S)-2-azanyl-4,5-dihydro-1H-imidazol-5-yl]-hydroxy-methyl]-5-[(R)-[(4S)-2-azanyl-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4,5-dihydroimidazol-4-yl]-hydroxy-methyl]-11-[[4-[(2R,3S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(6-methoxynaphthalen-2-yl)methoxy]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]-2-(hydroxymethyl)-14-[(1S)-1-phenylethyl]-3,6,9,12,15,18-hexazacyclooctadecane-1,4,7,10,13,16-hexone
  • (2S,5R,8S,11R,14S)-8-[(S)-[(4S)-2-amino-2-imidazolin-4-yl]-hydroxy-methyl]-5-[(R)-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]-2-imidazolin-4-yl]-hydroxy-methyl]-11-[4-[(2R,3S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy-5-[(6-methoxy-2-naphthyl)methoxy]-6-methylol-tetrahydropyran-2-yl]oxy-3,4-dihydroxy-6-methylol-tetrahydropyran-2-yl]oxybenzyl]-2-methylol-14-[(1S)-1-phenylethyl]-3,6,9,12,15,18-hexazacyclooctadecane-1,4,7,10,13,16-triquinone
  • (3S,6R,9S,12R,15S)-9-[(S)-[(4S)-2-amino-4,5-dihydro-3H-imidazol-4-yl]-hydroxymethyl]-6-[(R)-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4,5-dihydroimidazol-4-yl]-hydroxymethyl]-12-[[4-[(2R,3S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(6-methoxynaphthalen-2-yl)methoxy]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]-3-(hydroxymethyl)-15-[(1S)-1-phenylethyl]-1,4,7,10,13,16-hexazacyclooctadecane-2,5,8,11,14,17-hexone
  • (3S,6R,9S,12R,15S)-9-[(S)-[(4S)-2-amino-4,5-dihydro-3H-imidazol-4-yl]-hydroxy-methyl]-6-[(R)-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]-4,5-dihydroimidazol-4-yl]-hydroxy-methyl]-12-[4-[(2R,3S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy-5-[(6-methoxy-2-naphthyl)methoxy]-6-methylol-tetrahydropyran-2-yl]oxy-3,4-dihydroxy-6-methylol-tetrahydropyran-2-yl]oxybenzyl]-3-methylol-15-[(1S)-1-phenylethyl]-1,4,7,10,13,16-hexazacyclooctadecane-2,5,8,11,14,17-triquinone
  • (3S,6R,9S,12R,15S)-9-[(S)-[(4S)-2-amino-4,5-dihydro-3H-imidazol-4-yl]-hydroxy-methyl]-6-[(R)-[(4S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4,5-dihydroimidazol-4-yl]-hydroxy-methyl]-12-[[4-[(2R,3S,4R,5S,6R)-5-[(2R,3S,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(6-methoxynaphthalen-2-yl)methoxy]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]-3-(hydroxymethyl)-15-[(1S)-1-phenylethyl]-1,4,7,10,13,16-hexazacyclooctadecane-2,5,8,11,14,17-hexone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0468 0.0864 0.8982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0556 0.3845
Leishmania major casein kinase II, putative 0.0142 0.0242 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.0536 0.3709
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0123 0.0206 0.0585
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.001 0.0067
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0447 0.0824 0.8529
Echinococcus granulosus axis inhibition protein axin 0.002 0.001 0.0009
Brugia malayi M-phase phosphoprotein, mpp8 0.0104 0.017 0.119
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0092 0.0148 0.0148
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0483 0.3379
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Leishmania major phosphatidylinositol 3-kinase, putative 0.019 0.0334 0.0902
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0107 0.0177 0.1932
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0035 0.0035
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.019 0.0334 0.228
Loa Loa (eye worm) hypothetical protein 0.0554 0.1029 0.5497
Toxoplasma gondii hypothetical protein 0.0055 0.0078 0.0849
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0315 0.0573 0.3964
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0044 0.0725
Onchocerca volvulus 0.0053 0.0073 0.1193
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0357 0.0653 0.4566
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0063 0.0092 0.0865
Schistosoma mansoni hypothetical protein 0.0099 0.0162 0.0764
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.001 0.0067
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Leishmania major hypothetical protein, unknown function 0.0107 0.0177 0.0474
Onchocerca volvulus 0.0028 0.0025 0.0403
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0187 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.001 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0025 0.0131
Trypanosoma brucei polo-like protein kinase 0.0198 0.035 0.3578
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0028 0.0025 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0076
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0038 0.0044 0.0111
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0519 0.0961 0.2618
Loa Loa (eye worm) hypothetical protein 0.0176 0.0307 0.1641
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0187 0.0995
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.0902
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0131
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0208 0.0368 0.1055
Loa Loa (eye worm) hypothetical protein 0.0257 0.0462 0.2469
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0031 0.0162
Brugia malayi hypothetical protein 0.0037 0.0043 0.0299
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Brugia malayi hypothetical protein 0.002 0.001 0.0067
Echinococcus granulosus casein kinase ii subunit beta 0.0038 0.0044 0.0044
Onchocerca volvulus Serine\/threonine kinase homolog 0.0198 0.035 0.5778
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0519 0.0961 0.096
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0107 0.0177 0.5174
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0187 0.0882
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0033 0.0035 0.0245
Schistosoma mansoni hypothetical protein 0.0189 0.0332 0.157
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0187 0.1245
Loa Loa (eye worm) hypothetical protein 0.0169 0.0294 0.157
Schistosoma mansoni hypothetical protein 0.0053 0.0073 0.0345
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0053 0.0073 0.0794
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Toxoplasma gondii hypothetical protein 0.002 0.001 0.0114
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0031 0.003
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.0902 0.0901
Brugia malayi Serotonin receptor 0.0483 0.0892 0.6242
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0107 0.0177 0.1176
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0107 0.0177 0.5174
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0028 0.0025 0.0108
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0025 0.0131
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0382 0.07 0.4862
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.003 0.0142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0315 0.0573 0.3964
Echinococcus multilocularis Zinc finger, PHD finger 0.019 0.0334 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6122
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0044 0.0118
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.001 0.0067
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0005 0.0022
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0764 0.1429 1
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0038 0.0044 0.0358
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0176 0.0307 0.088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0519 0.0961 0.6719
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0519 0.0961 0.6697
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0457 0.0843 0.876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0187 0.05
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0189 0.0332 0.0331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0126
Schistosoma mansoni fkbp-rapamycin associated protein 0.0268 0.0483 0.2288
Brugia malayi Casein kinase II, alpha chain 0.0142 0.0242 0.1693
Onchocerca volvulus 0.0107 0.0177 0.2913
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0017 0.0113
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.019 0.0334 0.2332
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.0438 0.2342
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000034868
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0572 0.1063 0.7418
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0891
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0187 0.053
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.007 0.0328
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.0269 0.1437
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.5
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.001 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0117 0.0117
Toxoplasma gondii FATC domain-containing protein 0.0283 0.0512 0.5596
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.001 0.0009
Plasmodium vivax glycogen synthase kinase 3, putative 0.0053 0.0073 0.2171
Echinococcus granulosus serine protein kinase ATM 0.0283 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0488 0.0902 0.4818
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0187
Brugia malayi Cytochrome P450 family protein 0.002 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0161
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0519 0.0961 0.2773
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Schistosoma mansoni axis inhibition protein axin 0.002 0.001 0.0045
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.003 0.0328
Brugia malayi follicle stimulating hormone receptor 0.0245 0.0438 0.3066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0296 0.0536 0.5861
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.001 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0043 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.035 0.1658
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0519 0.0961 0.096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0143
Giardia lamblia Hypothetical protein 0.0107 0.0177 0.1577
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0043 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0187 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0177 0.1176
Schistosoma mansoni axis inhibition protein axin 0.002 0.001 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.1827 0.3454 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Echinococcus multilocularis axis inhibition protein axin 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.037
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0177 0.9446
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.05 0.0924 0.2519
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0187 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0198 0.035 0.1871
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Echinococcus multilocularis expressed conserved protein 0.0084 0.0133 0.0133
Entamoeba histolytica protein kinase rad3, putative 0.0268 0.0483 0.3334
Entamoeba histolytica hypothetical protein 0.0283 0.0512 0.3538
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0468 0.0864 0.6016
Loa Loa (eye worm) hypothetical protein 0.0189 0.0332 0.1771
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0509 0.0942 0.2719
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0078 0.0477
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.0054 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.0278 0.1892
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0332 0.0606 0.3237
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.038 0.2027
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Loa Loa (eye worm) hypothetical protein 0.0104 0.0171 0.091
Loa Loa (eye worm) RGS-3 protein 0.002 0.001 0.0051
Schistosoma mansoni lamin 0.0028 0.0025 0.0116
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.019 0.0334 0.0333
Brugia malayi hypothetical protein 0.0488 0.0902 0.6307
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0864 0.4616
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0189 0.0332 0.0331
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.019 0.0334 0.3645
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.001 0.0051
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0606 0.287
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0107 0.0177 0.1176
Loa Loa (eye worm) CYP4Cod1 0.002 0.001 0.0053
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.019 0.0334 0.228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0031 0.003
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0436 0.3
Trypanosoma brucei protein kinase, putative 0.0053 0.0073 0.0656
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Leishmania major hypothetical protein, conserved 0.1934 0.3659 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0208 0.0368 0.1965
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Brugia malayi Cytochrome P450 family protein 0.002 0.001 0.007
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0162 0.1072
Brugia malayi intracellular kinase 0.0053 0.0073 0.0506
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0107 0.0177 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0213 0.143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0177 0.1235
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Schistosoma mansoni casein kinase II beta subunit 0.0038 0.0044 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Entamoeba histolytica serine/threonine protein kinase, putative 0.0198 0.035 0.2398
Brugia malayi hypothetical protein 0.0104 0.0171 0.1191
Onchocerca volvulus 0.0042 0.0053 0.0865
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0033 0.0035 0.0165
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni hypothetical protein 0.0107 0.0177 0.0836
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0268 0.0483 0.0483
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.035 0.1004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0764 0.1429 1
Plasmodium vivax hypothetical protein 0.0107 0.0177 0.5296
Echinococcus multilocularis expressed protein 0.0386 0.0709 0.0708
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0014 0.0013
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.3401
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0043 0.0202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0044 0.1096
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0017 0.0016
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0572 0.1063 0.7418
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.001 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0764 0.1429 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.5296
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0014 0.0028
Brugia malayi Pre-SET motif family protein 0.0031 0.0031 0.0211
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.019 0.0334 0.0333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0512 0.3581
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0556 0.3845
Echinococcus granulosus expressed conserved protein 0.0084 0.0133 0.0133
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0177 0.0943
Plasmodium falciparum glycogen synthase kinase 3 0.0053 0.0073 0.1967
Schistosoma mansoni hypothetical protein 0.0174 0.0304 0.1438
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Toxoplasma gondii CMGC kinase, CK2 family 0.0142 0.0242 0.2648
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0639 0.119 0.8316
Brugia malayi Protein kinase domain containing protein 0.0018 0.0007 0.0047
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0092 0.0148 0.0699
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0013 0.0066
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0068 0.0321
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0044 0.1322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0033 0.0035 0.0035
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0283 0.0512 0.2425
Trichomonas vaginalis PIKK family atypical protein kinase 0.033 0.0601 0.4165
Brugia malayi Csnk2b protein 0.0038 0.0044 0.0308
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0187 0.0186
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0142 0.0242 0.1293
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0185 0.0325 0.1734
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0509 0.0942 0.4463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0961 0.6697
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0509 0.0942 0.6589
Brugia malayi hypothetical protein 0.0169 0.0294 0.2056
Brugia malayi Protein kinase domain containing protein 0.0332 0.0606 0.4238
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0362 0.0662 0.4595
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.035 0.1004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.1752
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0315 0.0573 0.3964
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0054
Trypanosoma cruzi cytochrome P450, putative 0.002 0.001 0.0019
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0187 0.0995
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0014 0.0028
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0187 0.1855
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0468 0.0864 0.2353
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0043 0.0299
Trypanosoma brucei Casein kinase II 0.0142 0.0242 0.2441
Brugia malayi Cytochrome P450 family protein 0.0031 0.0031 0.0212
Schistosoma mansoni phosphatidylinositol 4-kinase 0.019 0.0334 0.1579
Onchocerca volvulus 0.0104 0.017 0.2806
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Echinococcus granulosus lamin 0.0028 0.0025 0.0024
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0352 0.0643 0.3434
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0078 0.0477
Leishmania major cytochrome p450-like protein 0.002 0.001 0.0018
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.0902 0.0901
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0107 0.0177 0.1176
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.0092 0.0257
Echinococcus multilocularis lamin 0.0028 0.0025 0.0024
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0519 0.0961 0.6697
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0073 0.0442
Schistosoma mansoni kinase 0.0102 0.0167 0.0789
Echinococcus granulosus tumor protein p63 0.035 0.0639 0.0638
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0278 0.1892
Loa Loa (eye worm) hypothetical protein 0.0107 0.0177 0.0943
Brugia malayi PAS domain containing protein 0.005 0.0068 0.0474
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.0000000073565
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0044 0.0243
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0035 0.0035
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0049 0.0066 0.0352
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0279 0.0504 0.3483
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0053 0.0073 0.0342
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1122 0.211 0.211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Loa Loa (eye worm) hypothetical protein 0.0268 0.0483 0.2581
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0053 0.0073 0.0189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0042
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.019 0.0334 0.3645
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0198 0.035 0.035
Onchocerca volvulus 0.0051 0.007 0.1143
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0028 0.0025 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0004
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0073 0.0386
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0107 0.0177 0.0502
Mycobacterium ulcerans putative regulatory protein 0.002 0.001 0.0007
Echinococcus multilocularis casein kinase ii subunit beta 0.0038 0.0044 0.0044
Echinococcus granulosus intermediate filament protein 0.0028 0.0025 0.0024
Echinococcus granulosus high voltage activated calcium channel beta 0.009 0.0143 0.0143
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0117 0.0117
Echinococcus granulosus expressed protein 0.0386 0.0709 0.0708
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0053 0.0248
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0044 0.1096
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0519 0.0961 0.4551
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0332 0.0606 1
Toxoplasma gondii GAF domain-containing protein 0.002 0.001 0.0114
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.001 0.0009
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0107 0.0177 0.5296
Leishmania major phosphatidylinositol 3-kinase, putative 0.0457 0.0843 0.2295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0509 0.0942 0.0942
Schistosoma mansoni protein kinase 0.0142 0.0242 0.1146
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0509 0.0942 0.0942
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0177 0.1235
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.019 0.0334 0.1781
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0092 0.0582
Echinococcus granulosus casein kinase ii subunit alpha 0.0142 0.0242 0.0242
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0073 0.0442
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Echinococcus granulosus single minded 2 0.0037 0.0043 0.0043
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0014 0.0094
Plasmodium vivax hypothetical protein, conserved 0.002 0.001 0.0303
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Onchocerca volvulus 0.0107 0.0177 0.2913
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0177 0.9446
Trypanosoma cruzi casein kinase II, putative 0.0142 0.0242 0.0691
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.0045
Schistosoma mansoni survival motor neuron protein 0.0099 0.0162 0.0764
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0044 0.0243
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.001 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0519 0.0961 0.2618
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.009 0.0143 0.0677
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.019 0.0334 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.0502
Loa Loa (eye worm) calcium channel 0.0033 0.0035 0.0187
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0017 0.0016
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0332 0.0606 0.0605
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0038 0.0044 0.0485
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0315 0.0573 0.4004
Echinococcus granulosus cyclin dependent kinase 19 0.0138 0.0236 0.0236
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0764 0.1429 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.0092 0.0257
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.019 0.0334 0.1579
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0198 0.035 0.0948
Echinococcus multilocularis musashi 0.0028 0.0025 0.0024
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.009 0.0143 0.0142
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0017 0.0087
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0028 0.0025 0.0108
Brugia malayi FAT domain containing protein 0.0189 0.0332 0.2318
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0143
Toxoplasma gondii hypothetical protein 0.002 0.001 0.0114
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0364 0.0667 0.3158
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.019 0.0334 0.0333
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0554 0.1029 0.1028
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.0956
Loa Loa (eye worm) RecQ helicase 0.0022 0.0014 0.0072
Echinococcus multilocularis regulator of G protein signaling 0.002 0.001 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0315 0.0573 0.3964
Schistosoma mansoni intermediate filament proteins 0.0028 0.0025 0.0116
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0242 0.1637
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0654
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0044 0.0725
Leishmania major phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.0474
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0187 0.0186
Onchocerca volvulus 0.0099 0.0162 0.2663
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.0000000073565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0311 0.0565 0.3909
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Leishmania major phosphatidylinositol kinase, putative 0.0107 0.0177 0.0474
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0044 0.0118
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0028 0.0025 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0236 0.1117
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0107 0.0177 0.0502
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.526 1 1
Schistosoma mansoni hypothetical protein 0.0174 0.0304 0.1438
Loa Loa (eye worm) phosphatidylinositol 3 0.0519 0.0961 0.5133
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.001 0.0045
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0035 0.0035
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.0054 0.0146
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0028 0.0025 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0657 0.1225 0.8558
Brugia malayi serine/threonine-protein kinase plk-2 0.0198 0.035 0.2449
Mycobacterium ulcerans putative regulatory protein 0.002 0.001 0.0007
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0187 0.1245
Brugia malayi Protein kinase domain containing protein 0.0138 0.0236 0.1649
Echinococcus multilocularis protein kinase shaggy 0.0053 0.0073 0.0072
Loa Loa (eye worm) phosphatidylinositol kinase 0.0107 0.0177 0.0943
Onchocerca volvulus 0.0028 0.0025 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0078 0.0477
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0233 0.0416 0.4146
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0185 0.0325 0.227
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Loa Loa (eye worm) gastrulation defective protein 1 0.0135 0.0229 0.1224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0133
Brugia malayi hypoxia-induced factor 1 0.0156 0.0269 0.1881
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0107 0.0177 0.1752
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.001 0.0009
Schistosoma mansoni z-protein (S1r protein) 0.002 0.001 0.0045
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0044 0.1322
Onchocerca volvulus 0.0037 0.0043 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0162 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0512 0.3538
Toxoplasma gondii ck2 beta subunit 0.0038 0.0044 0.0485
Loa Loa (eye worm) phosphatidylinositol 3 0.0996 0.1871 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.001 0.0007
Entamoeba histolytica protein kinase, putative 0.0053 0.0073 0.0442
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0053 0.0073 0.0072
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0035 0.0035
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0035 0.0035
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0063 0.0092 0.0865
Brugia malayi hypothetical protein 0.002 0.001 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0483 0.3334
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0554 0.1029 0.1028
Echinococcus granulosus protein kinase shaggy 0.0053 0.0073 0.0072
Toxoplasma gondii 6-phosphofructokinase 0.003 0.003 0.0328
Brugia malayi phosphofructokinase 0.0113 0.0187 0.1303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0556 0.3845
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0028 0.0025 0.0025
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.019 0.0334 0.228
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1122 0.211 0.211
Echinococcus multilocularis lamin dm0 0.0028 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Entamoeba histolytica hypothetical protein 0.0107 0.0177 0.1176
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0283 0.0512 0.528
Giardia lamblia Phosphatidylinositol 4-kinase 0.0107 0.0177 0.1577
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0073 0.0442
Giardia lamblia Kinase, CMGC CK2 0.0142 0.0242 0.2281
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.001 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.0332 0.2266
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.5296
Plasmodium vivax unspecified product 0.0142 0.0242 0.7262
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0051
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0033 0.0035 0.0035
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0076
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0107 0.0177 0.1932
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0073 0.0442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0143
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.1572 0.1572
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Giardia lamblia Kinase, PLK 0.0198 0.035 0.3442
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0028 0.0025 0.0117
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0053 0.0073 0.0386
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0092 0.0148 0.0699
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Trypanosoma brucei target of rapamycin kinase 3, putative 0.05 0.0924 0.962
Brugia malayi 6-phosphofructokinase 0.0113 0.0187 0.1303
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0283 0.0512 0.1473
Loa Loa (eye worm) Csnk2b protein 0.0038 0.0044 0.0235
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0339 0.0618 0.4283
Toxoplasma gondii target of rapamycin (TOR), putative 0.0495 0.0915 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.001 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0764 0.1429 0.4131
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.0483 0.139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0162 0.1129
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.0092 0.0257
Trypanosoma cruzi cytochrome P450, putative 0.002 0.001 0.0019
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0033 0.0035 0.0165
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0053 0.0073 0.0072
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0519 0.0961 0.2773
Brugia malayi intermediate filament protein 0.0028 0.0025 0.0172
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0509 0.0942 0.2719
Loa Loa (eye worm) hypothetical protein 0.0104 0.017 0.0909
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0017 0.0087
Entamoeba histolytica hypothetical protein 0.0037 0.0043 0.0234
Trypanosoma cruzi target of rapamycin kinase 3 0.05 0.0924 0.2668
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0279 0.0504 0.3483
Echinococcus multilocularis tumor protein p63 0.035 0.0639 0.0638
Echinococcus multilocularis high voltage activated calcium channel beta 0.009 0.0143 0.0143
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6122
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0654
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0177 0.5296
Leishmania major phosphatidylinositol kinase related protein, putative 0.0123 0.0206 0.0553
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0073 0.0458
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0035 0.0035
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Echinococcus multilocularis casein kinase ii subunit alpha 0.0142 0.0242 0.0242
Schistosoma mansoni hypothetical protein 0.0084 0.0133 0.0628
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0107 0.0177 0.0176
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0142
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0187 0.1245
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Giardia lamblia Casein kinase II beta chain 0.0038 0.0044 0.0154
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0044 0.0243
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0764 0.1429 0.4131
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0031 0.003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.003 0.0142
Schistosoma mansoni single-minded 0.005 0.0068 0.0321
Giardia lamblia GTOR 0.0519 0.0961 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.001 0.0053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.019 0.0334 0.228
Echinococcus granulosus bloom syndrome protein 0.0022 0.0014 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0187 0.1245
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0187 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.019 0.0334 0.0956
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0044 0.0243
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.0054 0.0312
Brugia malayi 6-phosphofructokinase 0.0113 0.0187 0.1303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0332 0.0606 0.4238
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0092 0.0148 0.0148
Echinococcus multilocularis geminin 0.0174 0.0304 0.0303
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0138 0.0236 0.126
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0107 0.0177 0.0502
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0764 0.1429 1
Echinococcus multilocularis serine protein kinase ATM 0.0283 0.0512 0.0512
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0028 0.0028
Schistosoma mansoni lamin 0.0028 0.0025 0.0116
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0025 0.0172
Plasmodium falciparum casein kinase 2, alpha subunit 0.0142 0.0242 0.7191
Plasmodium falciparum phosphatidylinositol 3-kinase 0.019 0.0334 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0519 0.0961 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0315 0.0573 0.5917
Entamoeba histolytica casein kinase, putative 0.0142 0.0242 0.1637
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0961 0.6697
Brugia malayi SH2 domain containing protein 0.0352 0.0643 0.4496
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.009 0.0143 0.0142
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0063 0.0092 0.0092
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0187 1
Echinococcus multilocularis cyclin dependent kinase 19 0.0138 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0037 0.0043 0.0202
Entamoeba histolytica hypothetical protein 0.0107 0.0177 0.1176
Loa Loa (eye worm) hypothetical protein 0.0296 0.0536 0.2865
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0145 0.0249 0.2514
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0198 0.035 0.035
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.003 0.0328
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0063 0.0092 0.0092
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0107 0.0177 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.0888 0.6187
Schistosoma mansoni voltage-gated cation channel 0.0033 0.0035 0.0165
Giardia lamblia Kinase, CMGC GSK 0.0053 0.0073 0.0458
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Echinococcus granulosus lamin dm0 0.0028 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0495 0.0915 0.6377
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1122 0.211 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.0924 0.6442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0843 0.5867
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0107 0.0177 0.0176
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.019 0.0334 0.228
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0063 0.0092 0.0582
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0177 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0177 0.1176
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0043 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0242 0.1637
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0187 0.0882
Plasmodium vivax SET domain protein, putative 0.0031 0.0031 0.0906
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0332 0.0606 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0481 0.0888 0.6187
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.001 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0315 0.0573 0.5917
Onchocerca volvulus 0.0104 0.017 0.2806
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Entamoeba histolytica hypothetical protein 0.0107 0.0177 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6123
Echinococcus multilocularis 0.0107 0.0177 0.0176
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0107 0.0177 0.0836
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0033 0.0035 0.0035
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0268 0.0483 0.0483
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0053 0.0073 0.02
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0031 0.0334
Entamoeba histolytica hypothetical protein 0.0639 0.119 0.8316
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0142 0.0242 0.7262
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0063 0.0092 0.0582
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.001 0.0045
Onchocerca volvulus 0.0243 0.0436 0.7194
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0891
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0315 0.0573 0.1649
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.035 0.2398
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0107 0.0177 0.1932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0879 0.6122
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0332 0.0606 0.3237
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0519 0.0961 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0961 0.6697
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0557 0.1033 0.7229
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0063 0.0092 0.0436
Brugia malayi Pre-SET motif family protein 0.0214 0.038 0.2653
Echinococcus granulosus geminin 0.0174 0.0304 0.0303

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) <= 0.06 ug ml-1 In vitro minimum inhibitory concentration of the compound against Streptococcus species ChEMBL. 12873519
MIC (functional) = 0.25 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus aureus; 0.25-1 ChEMBL. 12873519
MIC (functional) = 1 ug ml-1 In vitro minimum inhibitory concentration of the compound against Enterococcus species; 1-2 ChEMBL. 12873519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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