Detailed information for compound 401582

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1523.77 | Formula: C71H114N18O19
  • H donors: 19 H acceptors: 19 LogP: -1.56 Rotable bonds: 57
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(C[C@@H](C(=O)NC(C(=O)N[C@H](C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(C(=O)N[C@H](C(=O)O)CCC(=O)N)(C)C)CC(C)C)CCC(=O)N)(C)C)(C)C)(C)C)CCC(=O)N)(C)C)NC(=O)C(NC(=O)C(NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)C)C)(C)C)(C)C)C
  • InChi: 1S/C71H114N18O19/c1-35(2)31-45(55(98)85-66(9,10)59(103)81-44(57(100)101)27-30-50(74)93)78-52(95)42(25-28-48(72)91)79-60(104)67(11,12)88-64(108)71(19,20)89-63(107)70(17,18)84-54(97)43(26-29-49(73)92)80-58(102)65(7,8)86-56(99)46(32-36(3)4)82-61(105)68(13,14)87-62(106)69(15,16)83-51(94)37(5)76-53(96)47(77-38(6)90)33-39-34-75-41-24-22-21-23-40(39)41/h21-24,34-37,42-47,75H,25-33H2,1-20H3,(H2,72,91)(H2,73,92)(H2,74,93)(H,76,96)(H,77,90)(H,78,95)(H,79,104)(H,80,102)(H,81,103)(H,82,105)(H,83,94)(H,84,97)(H,85,98)(H,86,99)(H,87,106)(H,88,108)(H,89,107)(H,100,101)/t37-,42-,43-,44-,45-,46-,47-/m0/s1
  • InChiKey: YGXQDXSKNMACDG-NCIRRWTHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0241 0.029 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0703 0.0886 0.0885
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.0273 0.2285
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.001 0.0081
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0007 0.0007
Echinococcus multilocularis serine protein kinase ATM 0.0388 0.048 0.048
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.0018 0.0099
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.0189 0.1209
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0131 0.1069
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0201
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0021 0.0122
Entamoeba histolytica hypothetical protein 0.0146 0.0168 0.1383
Schistosoma mansoni survival motor neuron protein 0.0104 0.0114 0.0645
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0065 0.0065
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0131 0.7719
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Entamoeba histolytica hypothetical protein 0.0388 0.048 0.4072
Entamoeba histolytica casein kinase, putative 0.0148 0.017 0.1406
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0017 0.011
Echinococcus multilocularis geminin 0.0181 0.0214 0.0213
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0131 0.1069
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.7786 1 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0031 0.0208
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0693 0.0873 0.0872
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0038 0.0267
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0778 0.0982 0.8388
Onchocerca volvulus 0.0029 0.0017 0.0403
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0007 0.0038
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0243 0.0293 0.0838
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0146 0.0168 0.1383
Giardia lamblia Kinase, CMGC CK2 0.0148 0.017 0.1726
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0007 0.0038
Echinococcus multilocularis lamin dm0 0.0029 0.0017 0.0017
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0146 0.0168 0.0953
Echinococcus granulosus protein kinase shaggy 0.0055 0.0051 0.0051
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Toxoplasma gondii hypothetical protein 0.0058 0.0055 0.064
Brugia malayi FAT domain containing protein 0.0266 0.0323 0.2763
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0013
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0031 0.0083
Echinococcus granulosus lamin 0.0029 0.0017 0.0017
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0306 0.2575
Brugia malayi hypothetical protein 0.0176 0.0207 0.1767
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0168 0.0167
Brugia malayi hypothetical protein 0.0021 0.0007 0.0057
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0131 0.0837
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0114 0.092
Giardia lamblia Casein kinase II beta chain 0.0039 0.0031 0.0117
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0031 0.0725
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0373 0.046 0.132
Loa Loa (eye worm) phosphatidylinositol 3 0.123 0.1564 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0051 0.038
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0146 0.0168 0.1383
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0051 0.158
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0025 0.0025
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Loa Loa (eye worm) calcium channel 0.0035 0.0025 0.0157
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.0886 0.7561
Schistosoma mansoni hypothetical protein 0.0055 0.0052 0.0291
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.0426 0.2422
Entamoeba histolytica hypothetical protein 0.0146 0.0168 0.1383
Echinococcus granulosus serine protein kinase ATM 0.0388 0.048 0.048
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0018 0.0093
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.029 0.3402
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1381 0.1757 0.1757
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0168 0.1433
Echinococcus multilocularis lamin 0.0029 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0373 0.046 0.046
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0037 0.021
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0031 0.0725
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.0886 0.7561
Echinococcus granulosus expressed protein 0.0402 0.0498 0.0498
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0007 0.0007
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0007 0.0041
Brugia malayi phosphofructokinase 0.0117 0.0131 0.112
Brugia malayi hypothetical protein 0.0508 0.0634 0.5419
Toxoplasma gondii target of rapamycin (TOR), putative 0.0679 0.0854 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.086 0.7341
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Brugia malayi serine/threonine-protein kinase plk-2 0.0207 0.0246 0.2105
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0131 0.7719
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0693 0.0873 0.7463
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Casein kinase II, alpha chain 0.0148 0.017 0.1455
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.0000000051701
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0007 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7067
Entamoeba histolytica protein kinase, putative 0.0055 0.0051 0.038
Brugia malayi hypothetical protein 0.0021 0.0007 0.0057
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0241 0.029 0.1651
Echinococcus granulosus bloom syndrome protein 0.0023 0.001 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0038
Onchocerca volvulus 0.0146 0.0168 0.3934
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0148 0.017 0.5861
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0007 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0168 0.1433
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0031 0.0083
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0146 0.0168 0.5684
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0114 0.092
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0703 0.0886 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.012
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0025 0.0025
Echinococcus multilocularis high voltage activated calcium channel beta 0.0093 0.0101 0.01
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0021 0.5
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0207 0.0246 0.0246
Brugia malayi Protein kinase domain containing protein 0.0144 0.0166 0.1418
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0012 0.0011
Brugia malayi Csnk2b protein 0.0039 0.0031 0.0265
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0391 0.0484 0.139
Entamoeba histolytica protein kinase domain containing protein 0.0148 0.017 0.1406
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0391 0.0484 0.4104
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0924 0.1169 0.3368
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.0246 0.0704
Brugia malayi hypothetical protein 0.0039 0.003 0.0257
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0241 0.029 0.2439
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0065 0.05
Toxoplasma gondii CMGC kinase, CK2 family 0.0148 0.017 0.1995
Echinococcus multilocularis musashi 0.0029 0.0017 0.0017
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0093 0.01 0.01
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0012 0.0098
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0017 0.0147
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Pre-SET motif family protein 0.0032 0.0021 0.0181
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0025 0.014
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0207 0.0246 0.0246
Echinococcus multilocularis casein kinase ii subunit beta 0.0039 0.0031 0.0031
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0065 0.05
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0443 0.055 0.3129
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0065 0.0658
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0241 0.029 0.1856
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0038 0.0267
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0168 0.0167
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0391 0.0484 0.4104
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.0634 0.0633
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0185 0.0219 0.2407
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0168 0.1071
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0131 0.0352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0874 0.1105 0.1105
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0096 0.0104 0.0104
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0017 0.011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0112
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0693 0.0873 0.4964
Trypanosoma brucei Casein kinase II 0.0148 0.017 0.1857
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.029 0.0831
Loa Loa (eye worm) hypothetical protein 0.0366 0.0452 0.2889
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0021 0.072
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0388 0.048 0.5385
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0417 0.0517 0.4391
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0693 0.0872 0.7447
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0065 0.018
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0093 0.0101 0.0571
Brugia malayi hypoxia-induced factor 1 0.0162 0.0189 0.1617
Loa Loa (eye worm) hypothetical protein 0.0373 0.046 0.294
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0241 0.029 0.2439
Echinococcus multilocularis 0.0146 0.0168 0.0167
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0168 0.1071
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0168 0.5772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7066
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0021 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0131 0.1069
Brugia malayi intermediate filament protein 0.0029 0.0017 0.0147
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0671 0.0844 0.0843
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0051 0.038
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0639 0.0803 0.6848
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1381 0.1757 0.1757
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0038
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0639 0.0803 0.9057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Leishmania major phosphatidylinositol 4-kinase, putative 0.0146 0.0168 0.0452
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0241 0.029 0.029
Loa Loa (eye worm) gastrulation defective protein 1 0.0141 0.0161 0.103
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0065 0.018
Schistosoma mansoni casein kinase II beta subunit 0.0039 0.0031 0.0176
Leishmania major casein kinase II, putative 0.0148 0.017 0.0459
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0146 0.0168 0.1965
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0021 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0168 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7066
Echinococcus multilocularis expressed protein 0.0402 0.0498 0.0498
Toxoplasma gondii FATC domain-containing protein 0.0388 0.048 0.5625
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi hypothetical protein 0.0108 0.012 0.1023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0168 0.1433
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0146 0.0168 0.1827
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0651 0.0818 0.9226
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0144 0.0166 0.106
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0065 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0021 0.0021
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0025 0.014
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0051 0.038
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0346 0.0426 0.0426
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Plasmodium vivax unspecified product 0.0148 0.017 0.5861
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0266 0.0323 0.0323
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0773 0.0976 0.8335
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0022 0.0136
Loa Loa (eye worm) hypothetical protein 0.0243 0.0293 0.1871
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0021 0.0251
Leishmania major phosphatidylinositol 3-kinase, putative 0.0241 0.029 0.0788
Brugia malayi 6-phosphofructokinase 0.0117 0.0131 0.112
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0388 0.048 0.4106
Loa Loa (eye worm) phosphatidylinositol 3 0.0651 0.0818 0.5228
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0693 0.0873 0.0872
Giardia lamblia GTOR 0.0703 0.0886 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0412 0.0511 0.4336
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0065 0.05
Schistosoma mansoni hypothetical protein 0.0266 0.0323 0.1838
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0703 0.0886 0.2419
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0193 0.0228 0.1951
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0051 0.0325
Echinococcus multilocularis cyclin dependent kinase 19 0.0144 0.0166 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Toxoplasma gondii hypothetical protein 0.0021 0.0007 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0007 0.0086
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0007 0.0057
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0161 0.0188 0.0535
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0131 0.0837
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0031 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0065
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0131 0.141
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0051 0.0347
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0122
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0146 0.0168 0.0953
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.029 0.0831
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0924 0.1169 0.3368
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0039 0.0031 0.0078
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0096 0.0104 0.059
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0051 0.0289
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0018 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.086 0.7341
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0146 0.0168 0.1383
Loa Loa (eye worm) Csnk2b protein 0.0039 0.0031 0.0198
Brugia malayi SH2 domain containing protein 0.0366 0.0452 0.3864
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0412 0.0511 0.4336
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0346 0.0426 0.0426
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0007 0.0007
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0671 0.0844 0.0843
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0924 0.1169 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0114 0.097
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0025 0.021
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0051 0.0347
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0007 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.086 0.7341
Schistosoma mansoni lamin 0.0029 0.0017 0.0098
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0693 0.0873 0.2512
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0012 0.0073
Onchocerca volvulus 0.0108 0.012 0.2805
Echinococcus granulosus tumor protein p63 0.0364 0.0449 0.0449
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0684 0.086 0.9711
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.003 0.0171
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0412 0.0511 0.4336
Echinococcus granulosus high voltage activated calcium channel beta 0.0093 0.0101 0.01
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0007 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0651 0.0818 0.6976
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0131 0.0371
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0168 0.0167
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Trypanosoma brucei protein kinase, putative 0.0055 0.0051 0.0499
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0148 0.017 0.1088
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.0065 0.0368
Echinococcus granulosus expressed conserved protein 0.0088 0.0094 0.0093
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0201
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0021 0.0247
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0131 0.1069
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Schistosoma mansoni hypothetical protein 0.0039 0.003 0.0171
Entamoeba histolytica hypothetical protein 0.0146 0.0168 0.1383
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0122
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0924 0.1169 1
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0039 0.0031 0.0272
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0122
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0703 0.0886 0.5039
Brugia malayi PAS domain containing protein 0.0052 0.0048 0.0407
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.006
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.0246 0.0704
Giardia lamblia Hypothetical protein 0.0146 0.0168 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.0168 0.1383
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.001 0.0024
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0543 0.0679 0.7609
Loa Loa (eye worm) hypothetical protein 0.0508 0.0634 0.4051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Leishmania major phosphatidylinositol kinase, putative 0.0146 0.0168 0.0452
Echinococcus multilocularis casein kinase ii subunit alpha 0.0148 0.017 0.017
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0346 0.0426 0.3642
Trypanosoma brucei polo-like protein kinase 0.0207 0.0246 0.2721
Leishmania major hypothetical protein, unknown function 0.0146 0.0168 0.0452
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0012 0.0073
Loa Loa (eye worm) hypothetical protein 0.0266 0.0323 0.2065
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0021 0.0247
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0703 0.0886 0.2419
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0065 0.0658
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0146 0.0168 0.5772
Loa Loa (eye worm) hypothetical protein 0.0053 0.0049 0.0312
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.002 0.002
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0083 0.0082
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0007 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0193 0.1602
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0007 0.0057
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0051 0.0325
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.003 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0373 0.046 0.3933
Entamoeba histolytica protein kinase rad3, putative 0.0373 0.046 0.3898
Plasmodium vivax SET domain protein, putative 0.0032 0.0021 0.0731
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0703 0.0886 0.255
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0664 0.0835 0.7123
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0025 0.0025
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0296 0.0361 0.3934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.0475 0.4026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0021 0.0122
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0039 0.0031 0.0365
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0021 0.0247
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0241 0.029 0.2439
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0703 0.0886 0.0885
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0021 0.0526
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0146 0.0168 0.1965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0673 0.0847 0.7243
Onchocerca volvulus 0.0146 0.0168 0.3934
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0146 0.0168 0.0477
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.2709 0.3466 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0049 0.0277
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0146 0.0168 0.0477
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0031 0.0208
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0045
Trypanosoma cruzi target of rapamycin kinase 3 0.0684 0.086 0.2476
Loa Loa (eye worm) hypothetical protein 0.0146 0.0168 0.1071
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0065
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0241 0.029 0.2439
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0651 0.0818 0.2233
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0346 0.0426 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0241 0.029 0.2439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0373 0.046 0.3898
Schistosoma mansoni hypothetical protein 0.0088 0.0094 0.053
Leishmania major phosphatidylinositol 3-kinase, putative 0.0639 0.0803 0.2192
Entamoeba histolytica serine/threonine protein kinase, putative 0.0207 0.0246 0.2059
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0146 0.0168 0.5772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.086 0.7341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0639 0.0803 0.6848
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0384 0.0475 0.4026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0146 0.0168 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0007 0.0007
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0388 0.048 0.2731
Schistosoma mansoni protein kinase 0.0148 0.017 0.0968
Brugia malayi Serotonin receptor 0.0503 0.0627 0.5365
Brugia malayi Protein kinase domain containing protein 0.0346 0.0426 0.3642
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0108 0.012 0.0765
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0096 0.0104 0.0104
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0131 0.0837
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0025 0.0025
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0241 0.029 1
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0131 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0703 0.0886 0.7575
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0007 0.0007
Giardia lamblia Kinase, PLK 0.0207 0.0246 0.2604
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0388 0.048 0.1379
Onchocerca volvulus 0.0039 0.003 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0055 0.041
Schistosoma mansoni hypothetical protein 0.0104 0.0114 0.0645
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0038
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0051 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.0543 0.4611
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.006
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0029 0.0018 0.0017
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0131 0.0745
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0007 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0168 0.1071
Leishmania major cytochrome p450-like protein 0.0021 0.0007 0.0013
Echinococcus granulosus intermediate filament protein 0.0029 0.0017 0.0017
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0241 0.029 0.1651
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0012 0.0011
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0029 0.0018 0.015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0246 0.14
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0146 0.0168 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.0886 0.7561
Echinococcus granulosus lamin dm0 0.0029 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0273 0.2285
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi follicle stimulating hormone receptor 0.0255 0.0308 0.2635
Loa Loa (eye worm) hypothetical protein 0.0302 0.0369 0.2357
Brugia malayi Cytochrome P450 family protein 0.0032 0.0022 0.0182
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0031 0.1067
Loa Loa (eye worm) phosphatidylinositol 3 0.0703 0.0886 0.5662
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0241 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.0168 0.1383
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Giardia lamblia Phosphatidylinositol 4-kinase 0.0146 0.0168 0.1696
Schistosoma mansoni hypothetical protein 0.0181 0.0214 0.1213
Onchocerca volvulus 0.0055 0.0051 0.1193
Trypanosoma cruzi casein kinase II, putative 0.0148 0.017 0.0484
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0051 0.1752
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7067
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0007 0.0038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.011
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0457 0.0569 0.4863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7066
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0146 0.0168 0.5772
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0131 0.1069
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0018 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7067
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0391 0.0484 0.4104
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0122
Brugia malayi Pre-SET motif family protein 0.0222 0.0267 0.228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0038
Mycobacterium ulcerans putative regulatory protein 0.0039 0.003 0.1861
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0924 0.1169 1
Echinococcus granulosus single minded 2 0.0039 0.003 0.003
Leishmania major phosphatidylinositol kinase related protein, putative 0.0161 0.0188 0.0508
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0703 0.0886 0.7561
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0703 0.0886 1
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0146 0.0168 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Schistosoma mansoni fkbp-rapamycin associated protein 0.0373 0.046 0.2616
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0391 0.0484 0.5427
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0693 0.0872 0.7447
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0703 0.0886 0.7561
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0412 0.0511 0.3264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.086 0.7341
Schistosoma mansoni hypothetical protein 0.0181 0.0214 0.1213
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0246 0.0297 0.0849
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0065 0.0065
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.044 0.0547 0.4646
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0391 0.0484 0.4138
Echinococcus granulosus cyclin dependent kinase 19 0.0144 0.0166 0.0166
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Plasmodium vivax hypothetical protein 0.0146 0.0168 0.5772
Loa Loa (eye worm) RecQ helicase 0.0023 0.001 0.0061
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0684 0.086 0.2349
Loa Loa (eye worm) phosphatidylinositol kinase 0.0146 0.0168 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0639 0.0803 0.6848
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Onchocerca volvulus 0.0108 0.012 0.2805
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0021 0.0526
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0246 0.2059
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0029 0.0018 0.0017
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0055 0.041
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0007 0.0057
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0432 0.0536 0.6021
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0693 0.0873 0.2512
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0051 0.0051
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0146 0.0168 0.5684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0828 0.7067
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Onchocerca volvulus 0.0029 0.0017 0.0403
Schistosoma mansoni kinase 0.0106 0.0117 0.0666
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0007 0.0007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0412 0.0511 0.5981
Echinococcus granulosus geminin 0.0181 0.0214 0.0213
Schistosoma mansoni hypothetical protein 0.0146 0.0168 0.0953
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.0000000051701
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0048 0.0271
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0025 0.014
Brugia malayi bHLH-PAS transcription factor 0.0039 0.003 0.0257
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0051 0.0047 0.0296
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0007 0.0007
Echinococcus multilocularis tumor protein p63 0.0364 0.0449 0.0449
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi intracellular kinase 0.0055 0.0051 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.0854 0.7286
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0346 0.0426 0.2722
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1381 0.1757 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0207 0.0246 0.1573
Onchocerca volvulus 0.0253 0.0306 0.7192
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0051 0.0051
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0035
Schistosoma mansoni intermediate filament proteins 0.0029 0.0017 0.0098
Onchocerca volvulus 0.0053 0.0049 0.1143
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0131 0.0745
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0045
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0051 0.0051
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.0018 0.015
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0093 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0568 0.4827
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0083 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0055 0.041
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0031 0.1067
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0391 0.0484 0.4104
Loa Loa (eye worm) hypothetical protein 0.0176 0.0207 0.1321
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0038 0.0102
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0031 0.088
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000029424
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0323 0.2721
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0146 0.0168 0.1965
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0007 0.0007
Schistosoma mansoni lamin 0.0029 0.0017 0.0098
Brugia malayi M-phase phosphoprotein, mpp8 0.0108 0.012 0.1022
Echinococcus granulosus casein kinase ii subunit beta 0.0039 0.0031 0.0031
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0267 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0664 0.0835 0.7123
Toxoplasma gondii hypothetical protein 0.0021 0.0007 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0639 0.0803 0.6848
Onchocerca volvulus Serine\/threonine kinase homolog 0.0207 0.0246 0.5778
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0207 0.0246 0.0667
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0009 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.0511 0.4334
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0146 0.0168 0.0477
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0241 0.029 0.2483
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0007 0.0057
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0021 0.072
Loa Loa (eye worm) hypothetical protein 0.0671 0.0844 0.5394
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0266 0.0323 0.0323
Brugia malayi PXA domain containing protein 0.0022 0.0009 0.0074
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0051 0.014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.0308 0.197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0043
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0146 0.0168 0.0953
Leishmania major hypothetical protein, conserved 0.2854 0.3653 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0146 0.0168 0.1827
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0051 0.038
Onchocerca volvulus 0.0104 0.0114 0.2662
Mycobacterium leprae conserved hypothetical protein 0.0146 0.0168 1
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0166 0.0943
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0131 0.1069
Toxoplasma gondii ck2 beta subunit 0.0039 0.0031 0.0365
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.012 0.0764
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0241 0.029 0.0788
Onchocerca volvulus 0.0044 0.0037 0.0865
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.017 0.1406
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.0065 0.05
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0241 0.029 0.029
Brugia malayi 6-phosphofructokinase 0.0117 0.0131 0.112
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0471 0.0587 0.4992
Echinococcus multilocularis bloom syndrome protein 0.0023 0.001 0.0009
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0924 0.1169 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0241 0.029 0.029
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0346 0.0426 0.2722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.012
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0131 0.1069
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0031 0.0208
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0241 0.029 0.3224
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0201
Plasmodium falciparum casein kinase 2, alpha subunit 0.0148 0.017 0.5775
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0065
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0703 0.0886 0.255
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0131 0.0131
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.001 0.0024
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0007 0.0045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0924 0.1169 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0136
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0373 0.046 0.046
Loa Loa (eye worm) phosphatidylinositol 3 0.0246 0.0297 0.1895
Echinococcus multilocularis expressed conserved protein 0.0088 0.0094 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0388 0.048 0.4072
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.029 0.3402
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0168 0.0167
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0051 0.0598
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0193 0.0228 0.1458
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0065 0.05
Brugia malayi Protein kinase domain containing protein 0.0019 0.0005 0.0041
Echinococcus granulosus casein kinase ii subunit alpha 0.0148 0.017 0.017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0773 0.0976 0.8335
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0096 0.0104 0.059
Schistosoma mansoni single-minded 0.0052 0.0048 0.0271
Brugia malayi PXA domain containing protein 0.0022 0.0009 0.0074
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0031 0.0208
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.0634 0.0633

Activities

Activity type Activity value Assay description Source Reference
(functional) Evaluated for its ability to modify the core body temperature of mice; No activity ChEMBL. 12061880
NA (functional) 0 Evaluated for pigment induction capacity based on the P. destructiva halo color; No activity ChEMBL. 12061880
NA (functional) 0 Evaluated for its ability to modify the core body temperature of mice; No activity ChEMBL. 12061880

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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