Detailed information for compound 401710

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1214.35 | Formula: C53H79N15O16S
  • H donors: 17 H acceptors: 16 LogP: -9.07 Rotable bonds: 47
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N[C@H](C(=O)O)CCCN=C(N)N)CCC(=O)N)CCS)CC(=O)O)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)CO)Cc1ccccc1
  • InChi: 1S/C53H79N15O16S/c54-20-5-4-10-33(62-47(78)37(25-29-8-2-1-3-9-29)65-49(80)39(28-69)67-44(75)32(55)24-30-13-15-31(70)16-14-30)45(76)66-38(26-43(73)74)48(79)63-34(19-23-85)46(77)64-35(17-18-41(56)71)51(82)68-22-7-12-40(68)50(81)60-27-42(72)61-36(52(83)84)11-6-21-59-53(57)58/h1-3,8-9,13-16,32-40,69-70,85H,4-7,10-12,17-28,54-55H2,(H2,56,71)(H,60,81)(H,61,72)(H,62,78)(H,63,79)(H,64,77)(H,65,80)(H,66,76)(H,67,75)(H,73,74)(H,83,84)(H4,57,58,59)/t32-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
  • InChiKey: ASJWOVVUCFOXRS-LCQMPJFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0077 0.0326
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0038
Entamoeba histolytica casein kinase, putative 0.0137 0.0255 0.143
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.0061
Brugia malayi FAT domain containing protein 0.0175 0.0333 0.1929
Trypanosoma cruzi casein kinase II, putative 0.0137 0.0255 0.073
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.4966
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0157
Brugia malayi hypothetical protein 0.0019 0.001 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0064
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0047 0.0198
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0104 0.0186 0.199
Brugia malayi intracellular kinase 0.0051 0.0077 0.0442
Plasmodium vivax SET domain protein, putative 0.003 0.0032 0.0853
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.1724 0.4992
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0194 0.0374 0.0373
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0104 0.0186 0.1023
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0027 0.0094
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0077 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0098 0.0508
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0156 0.0156
Echinococcus granulosus survival motor neuron protein 1 0.0473 0.0951 0.095
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0197 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0267 0.0525 0.1987
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0047 0.103
Brugia malayi hypothetical protein 0.0036 0.0045 0.0261
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0338 0.0671 0.3857
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0846 0.1724 1
Leishmania major cytochrome p450-like protein 0.0019 0.0011 0.0019
Toxoplasma gondii target of rapamycin (TOR), putative 0.0464 0.0933 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0263 0.0517 0.2955
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0098 0.0097
Onchocerca volvulus 0.0096 0.017 0.2663
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.001 0.0058
Plasmodium falciparum glycogen synthase kinase 3 0.0051 0.0077 0.1849
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0037 0.0214
Echinococcus granulosus intermediate filament protein 0.0027 0.0026 0.0026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0487 0.0981 0.5664
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0478 0.0961 0.0961
Onchocerca volvulus 0.0101 0.018 0.2807
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0017 0.0073
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0045 0.0262
Brugia malayi hypothetical protein 0.0473 0.0951 0.5513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.0517 0.2955
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Echinococcus granulosus high voltage activated calcium channel beta 0.0087 0.0151 0.0151
Echinococcus multilocularis tumor protein p63 0.0339 0.0674 0.0673
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Leishmania major phosphatidylinositol kinase related protein, putative 0.0118 0.0216 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0186 0.1023
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0077 0.0473
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0037 0.0037
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Plasmodium vivax unspecified product 0.0137 0.0255 0.6836
Echinococcus multilocularis expressed conserved protein 0.0082 0.014 0.014
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.4966
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0098 0.0893
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0032 0.0339
Brugia malayi phosphofructokinase 0.0109 0.0197 0.1139
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0047 0.037
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0047 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0032 0.0345
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0846 0.1724 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0072 0.027
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0487 0.0981 0.2836
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0032 0.0839
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0075
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0197 0.0743
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0197 0.0838
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0192 0.0369 0.0369
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0047 0.0212
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0197 0.1087
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0057 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0338 0.0671 0.3857
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0156 0.059
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.1658 0.1657
Brugia malayi Protein kinase domain containing protein 0.0134 0.0249 0.1442
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0164 0.031 0.0888
Onchocerca volvulus 0.0104 0.0186 0.2901
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0032 0.0839
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0267 0.0525 0.5298
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0194 0.0374 0.4003
Schistosoma mansoni protein kinase 0.0137 0.0255 0.0966
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0487 0.0981 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0027 0.0099
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0026 0.011
Toxoplasma gondii CMGC kinase, CK2 family 0.0137 0.0255 0.2738
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.0634 0.3639
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0981 0.5664
Loa Loa (eye worm) hypothetical protein 0.0341 0.0678 0.2893
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0087 0.0151 0.057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Onchocerca volvulus 0.0036 0.0045 0.0705
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Echinococcus granulosus cyclin dependent kinase 19 0.0134 0.0249 0.0248
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.1073
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0141 0.0262 0.2589
Trichomonas vaginalis conserved hypothetical protein 0.0278 0.0548 0.3137
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0104 0.0186 0.0185
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0032 0.0339
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Leishmania major casein kinase II, putative 0.0137 0.0255 0.0687
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0051 0.0077 0.0211
Echinococcus granulosus lamin dm0 0.0027 0.0026 0.0026
Trypanosoma cruzi target of rapamycin kinase 3 0.0469 0.0943 0.2725
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1287 0.264 0.2639
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0098 0.0508
Mycobacterium ulcerans putative regulatory protein 0.002 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Loa Loa (eye worm) phosphatidylinositol 3 0.0438 0.0879 0.3753
Entamoeba histolytica serine/threonine protein kinase, putative 0.0192 0.0369 0.2094
Leishmania major phosphatidylinositol kinase, putative 0.0104 0.0186 0.0497
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.0098 0.0368
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0186 0.4966
Schistosoma mansoni hypothetical protein 0.0036 0.0045 0.017
Entamoeba histolytica hypothetical protein 0.0104 0.0186 0.1023
Trypanosoma brucei Casein kinase II 0.0137 0.0255 0.2521
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0338 0.0671 0.3857
Trichomonas vaginalis PIKK family atypical protein kinase 0.045 0.0905 0.5218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.012
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0197 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.0619 0.355
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0766
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Loa Loa (eye worm) hypothetical protein 0.0104 0.0186 0.0791
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0104 0.0186 0.0528
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0104 0.0186 0.4966
Echinococcus granulosus protein kinase shaggy 0.0051 0.0077 0.0076
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0253 0.0494 0.0494
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0037 0.0037
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0032 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.012
Entamoeba histolytica hypothetical protein 0.0702 0.1426 0.8262
Brugia malayi follicle stimulating hormone receptor 0.0239 0.0467 0.2708
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0038
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0032 0.0124
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0194 0.0374 0.0373
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.0639 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0104 0.0186 0.199
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0194 0.0374 0.2119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5161
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0338 0.0671 0.3857
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0487 0.0981 0.3715
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0487 0.0981 0.0981
Echinococcus multilocularis geminin 0.0169 0.032 0.032
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0606 0.1228 0.7119
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0098 0.0272
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0456 0.1947
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0056 0.0209
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0098 0.0272
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0487 0.0981 0.2669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0338 0.0671 0.3893
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.001 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0186 0.1075
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0478 0.0961 0.0961
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0478 0.0961 0.2779
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0104 0.0186 0.4843
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0192 0.0369 0.0998
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0077 0.0386
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.045 0.0905 0.5218
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0 0.0000000077582
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.101
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.0045
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0015 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0197 0.1087
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.001 0.001
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.0528
Echinococcus granulosus single minded 2 0.0036 0.0045 0.0045
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.001 0.001
Giardia lamblia Kinase, CMGC CK2 0.0137 0.0255 0.2357
Entamoeba histolytica hypothetical protein 0.0104 0.0186 0.1023
Schistosoma mansoni hypothetical protein 0.0096 0.017 0.0644
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0011 0.0045
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0487 0.0981 0.2836
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0032 0.0339
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0192 0.0369 0.1576
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0104 0.0186 0.1802
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0151 0.015
Loa Loa (eye worm) calcium channel 0.0032 0.0037 0.0157
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0017 0.0017
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.0639 0.0638
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0047 0.1244
Brugia malayi Protein kinase domain containing protein 0.0322 0.0639 0.3704
Echinococcus multilocularis cyclin dependent kinase 19 0.0134 0.0249 0.0248
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0098 0.0893
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0846 0.1724 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Brugia malayi serine/threonine-protein kinase plk-2 0.0192 0.0369 0.214
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0194 0.0374 1
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0064
Brugia malayi intermediate filament protein 0.0027 0.0026 0.015
Echinococcus multilocularis high voltage activated calcium channel beta 0.0087 0.0151 0.0151
Plasmodium falciparum casein kinase 2, alpha subunit 0.0137 0.0255 0.6759
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus granulosus lamin 0.0027 0.0026 0.0026
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0047 0.0046
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0175 0.0333 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.012
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0037 0.0037
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.001 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0384 0.0766 0.4408
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0192 0.0369 0.0369
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0369 0.1061
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0604 0.1223 0.1222
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0013 0.0056
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.002
Schistosoma mansoni intermediate filament proteins 0.0027 0.0026 0.0098
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.0639 0.2727
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0032 0.0615
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0047 0.0725
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Brugia malayi 6-phosphofructokinase 0.0109 0.0197 0.1139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.017 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0294 0.0581 0.3326
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0186 0.1075
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0047 0.0124
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4836 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Loa Loa (eye worm) hypothetical protein 0.0164 0.031 0.1321
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0027 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0249 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0981 0.5664
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0037 0.0139
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0026 0.015
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0742 0.1509 0.8745
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0057 0.0272
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0194 0.0374 0.1594
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.001
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0134 0.0249 0.1061
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0197 0.0196
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0077 0.0386
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.011
Leishmania major hypothetical protein, unknown function 0.0104 0.0186 0.0497
Trichomonas vaginalis set domain proteins, putative 0.0236 0.046 0.2621
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0082 0.0417
Schistosoma mansoni hypothetical protein 0.0175 0.0333 0.1259
Schistosoma mansoni ankyrin 23/unc44 0.0014 0 0.000000029393
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0186 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0279 0.1569
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0027 0.0094
Loa Loa (eye worm) gastrulation defective protein 1 0.0131 0.0242 0.1031
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0194 0.0374 0.0373
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0047 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0045 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0171 0.0936
Echinococcus granulosus serine protein kinase ATM 0.0267 0.0525 0.0524
Brugia malayi Csnk2b protein 0.0037 0.0047 0.0269
Loa Loa (eye worm) phosphatidylinositol 3 0.1143 0.2342 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Entamoeba histolytica protein kinase, putative 0.0051 0.0077 0.0386
Trypanosoma brucei protein kinase, putative 0.0051 0.0077 0.0677
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0197 0.056
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0037 0.0037
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0037 0.0139
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Giardia lamblia Casein kinase II beta chain 0.0037 0.0047 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.0045
Schistosoma mansoni fkbp-rapamycin associated protein 0.0253 0.0494 0.1872
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0077 0.0076
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0032 0.0124
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0604 0.1223 0.1222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0571 0.327
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0197 0.0527
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0194 0.0374 0.4003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0027 0.0094
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1287 0.264 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Echinococcus multilocularis musashi 0.0027 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0104 0.0186 0.1023
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0267 0.0525 0.1512
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0082 0.0417
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0057 0.0154
Brugia malayi hypoxia-induced factor 1 0.0151 0.0284 0.1644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.0639 0.2419
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0234 0.0456 0.1313
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0104 0.0186 0.0702
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Brugia malayi hypothetical protein 0.0101 0.018 0.1041
Schistosoma mansoni lamin 0.0027 0.0026 0.0098
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Giardia lamblia Kinase, PLK 0.0192 0.0369 0.3557
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Trypanosoma brucei polo-like protein kinase 0.0192 0.0369 0.3695
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0179 0.0342 0.1461
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0438 0.0879 0.8949
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.001 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0015 0.0024
Giardia lamblia Hypothetical protein 0.0104 0.0186 0.1622
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0338 0.0671 0.6809
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0194 0.0374 0.2165
Onchocerca volvulus 0.0236 0.046 0.7196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0032 0.0032
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0077 0.0076
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0015 0.0024
Schistosoma mansoni hypothetical protein 0.0104 0.0186 0.0702
Leishmania major hypothetical protein, conserved 0.1781 0.3665 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Giardia lamblia Phosphatidylinositol 4-kinase 0.0104 0.0186 0.1622
Brugia malayi Pre-SET motif family protein 0.0207 0.04 0.232
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0171 0.0936
Schistosoma mansoni hypothetical protein 0.0051 0.0077 0.0291
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0104 0.0186 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0224 0.1245
Mycobacterium leprae conserved hypothetical protein 0.0104 0.0186 0.9407
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0047 0.103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0186 0.1075
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0137 0.0255 0.1089
Onchocerca volvulus 0.0041 0.0056 0.0866
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0194 0.0374 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.018 0.104
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0037 0.0139
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0194 0.0374 0.2119
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0098 0.0272
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Echinococcus multilocularis Zinc finger, PHD finger 0.0194 0.0374 0.0373
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0846 0.1724 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0253 0.0494 0.0494
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0015 0.0014
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0427 0.0857 0.8719
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0369 0.1398
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.001 0.001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0017 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0625 0.1267 0.7334
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.1724 0.4992
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0075
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0104 0.0186 0.199
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Schistosoma mansoni hypothetical protein 0.0082 0.014 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0571 0.327
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.3738
Loa Loa (eye worm) hypothetical protein 0.0278 0.0548 0.2339
Leishmania major phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.0497
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0051 0.0077 0.0199
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Schistosoma mansoni hypothetical protein 0.0169 0.032 0.1212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0702 0.1426 0.8262
Echinococcus granulosus casein kinase ii subunit alpha 0.0137 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0035
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Loa Loa (eye worm) RecQ helicase 0.0021 0.0015 0.0061
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0156 0.059
Schistosoma mansoni single-minded 0.0049 0.0072 0.027
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0037 0.0037
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.0639 0.0638
Toxoplasma gondii FATC domain-containing protein 0.0267 0.0525 0.5625
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0175 0.0333 0.0332
Echinococcus multilocularis casein kinase ii subunit alpha 0.0137 0.0255 0.0255
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0197 0.0196
Toxoplasma gondii ck2 beta subunit 0.0037 0.0047 0.0501
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0482 0.0969 0.9878
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0487 0.0981 0.5664
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Brugia malayi hypothetical protein 0.0164 0.031 0.1797
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0478 0.0961 0.5575
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0338 0.0671 0.1937
Echinococcus multilocularis expressed protein 0.0374 0.0747 0.0747
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.1073
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.1802
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.0639 0.2727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus multilocularis survival motor neuron protein 1 0.0473 0.0951 0.095
Echinococcus granulosus bloom syndrome protein 0.0021 0.0015 0.0014
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0442 0.0886 0.5138
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0045 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0032 0.0032
Plasmodium vivax hypothetical protein, conserved 0.002 0.0011 0.0285
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0767
Echinococcus multilocularis lamin dm0 0.0027 0.0026 0.0026
Brugia malayi SH2 domain containing protein 0.0341 0.0678 0.393
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.001 0.001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.001 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0082 0.0417
Onchocerca volvulus 0.0027 0.0026 0.0404
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus multilocularis 0.0104 0.0186 0.0185
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0051 0.0077 0.0821
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0487 0.0981 0.2669
Mycobacterium ulcerans putative regulatory protein 0.002 0.0011 0.0007
Schistosoma mansoni kinase 0.0099 0.0176 0.0665
Brugia malayi hypothetical protein 0.0019 0.001 0.0058
Echinococcus granulosus tumor protein p63 0.0339 0.0674 0.0673
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.0528
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0284 0.121
Brugia malayi PAS domain containing protein 0.0049 0.0072 0.0414
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0037 0.0037
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0267 0.0525 0.3002
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.007 0.0297
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0077 0.0076
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1287 0.264 0.2639
Loa Loa (eye worm) hypothetical protein 0.0253 0.0494 0.211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Brugia malayi Protein kinase domain containing protein 0.0018 0.0008 0.0041
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0005 0.0018
Plasmodium vivax glycogen synthase kinase 3, putative 0.0051 0.0077 0.2043
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0194 0.0374 0.2119
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Onchocerca volvulus 0.005 0.0073 0.1143
Schistosoma mansoni lamin 0.0027 0.0026 0.0098
Loa Loa (eye worm) RGS-3 protein 0.0019 0.001 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0077 0.0386
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0104 0.0186 0.1023
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0047 0.0046
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.0061
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0151 0.015
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0027 0.0152
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0124 0.0123
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.083 0.4784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0571 0.327
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0118 0.0216 0.0616
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.001 0.0038
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0278 0.0548 0.5873
Leishmania major phosphatidylinositol 3-kinase, putative 0.0427 0.0857 0.233
Onchocerca volvulus 0.0101 0.018 0.2807
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0156 0.0156
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0038
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0253 0.0494 0.1424
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0104 0.0186 0.4843
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0047 0.0124
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0369 0.1061
Loa Loa (eye worm) phosphatidylinositol kinase 0.0104 0.0186 0.0791
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0037 0.0037
Onchocerca volvulus Serine\/threonine kinase homolog 0.0192 0.0369 0.5778
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0604 0.1223 0.522
Toxoplasma gondii hypothetical protein 0.0054 0.0082 0.0878
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0047 0.0501
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0297 0.0586 0.5931
Echinococcus granulosus expressed protein 0.0374 0.0747 0.0747
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0098 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0077 0.0386
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0058
Schistosoma mansoni survival motor neuron protein 0.0096 0.017 0.0644
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.001
Toxoplasma gondii GAF domain-containing protein 0.002 0.0011 0.0118
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0026 0.011
Onchocerca volvulus 0.0104 0.0186 0.2901
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0058
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.001 0.001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0197 1
Onchocerca volvulus 0.0027 0.0026 0.0404
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0194 0.0374 0.1413
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0047 0.1244
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0112
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0981 0.5664
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0197 0.0838
Echinococcus granulosus geminin 0.0169 0.032 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Echinococcus multilocularis lamin 0.0027 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0494 0.2824
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.04 0.1708
Brugia malayi Pre-SET motif family protein 0.003 0.0032 0.0185
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0047 0.0212
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Leishmania major phosphatidylinositol 3-kinase, putative 0.0194 0.0374 0.101
Giardia lamblia GTOR 0.0487 0.0981 1
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0333 0.1882
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0037 0.0037
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0197 0.0743
Plasmodium vivax hypothetical protein 0.0104 0.0186 0.4966
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0197 0.1915
Loa Loa (eye worm) hypothetical protein 0.0164 0.031 0.1323
Onchocerca volvulus 0.0051 0.0077 0.1193
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0255 0.143
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0077 0.0288
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0032 0.0032
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0104 0.0186 0.0702
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0386 0.0771 0.2918
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0027 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.0639 0.3704
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.003 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5161
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0047 0.0725
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0846 0.1724 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Schistosoma mansoni hypothetical protein 0.0169 0.032 0.1212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0487 0.0981 0.5689
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0487 0.0981 1
Brugia malayi Casein kinase II, alpha chain 0.0137 0.0255 0.148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.0879 0.5069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.0333 0.142
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0253 0.0494 0.2866
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0137 0.0255 0.6836
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0064
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.0467 0.1993
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0625 0.1267 0.7334
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0 0.0000000077582
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0312
Brugia malayi 6-phosphofructokinase 0.0109 0.0197 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0279 0.1569
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0124 0.0123
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0032 0.0615
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0267 0.0525 0.3043
Entamoeba histolytica hypothetical protein 0.0267 0.0525 0.3002
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0077 0.0326
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0118
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0487 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0011 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0032 0.0136
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0032 0.5
Brugia malayi Serotonin receptor 0.047 0.0946 0.5484
Loa Loa (eye worm) hypothetical protein 0.0287 0.0567 0.2418
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0247 0.0484 0.476
Loa Loa (eye worm) hypothetical protein 0.0473 0.0951 0.4059
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0045 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.0487 0.0981 0.4188
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0194 0.0374 0.2119
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0469 0.0943 0.9607
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0186 0.9407
Brugia malayi Cytochrome P450 family protein 0.003 0.0032 0.0185
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0045 0.1861
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0469 0.0943 0.2565
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0104 0.0186 0.1023
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.001 0.0058
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trypanosoma cruzi hypothetical protein, conserved 0.1678 0.345 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.001
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0073 0.0277
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.001 0.001
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0047 0.0175
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0104 0.0186 0.0528
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0478 0.0961 0.3641
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0197 0.1087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5161
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0194 0.0374 0.1413
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0017 0.0073
Echinococcus granulosus expressed conserved protein 0.0082 0.014 0.014
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0194 0.0374 0.2119
Echinococcus multilocularis serine protein kinase ATM 0.0267 0.0525 0.0524
Entamoeba histolytica protein kinase rad3, putative 0.0253 0.0494 0.2824
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0197 0.0838
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0179 0.0342 0.1984
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0438 0.0879 0.2391
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0478 0.0961 0.2779

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 48 uM Effective dose required for smooth muscle contraction in human fetal artery ChEMBL. 7932541
EC50 (functional) = 344 uM Effective dose required for smooth muscle contraction in guinea pig ileum ChEMBL. 7932541
pD2 (binding) = 3.64 Pharmacological activity against C5a receptor in guinea pig ileum ChEMBL. 7932541
pD2 (binding) = 4.4 Pharmacological activity against C5a receptor in human fetal artery ChEMBL. 7932541
Platelet aggregation (functional) = 500 uM Platelet aggregation in guinea pig ChEMBL. 7932541

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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