Detailed information for compound 401860

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1270.46 | Formula: C57H87N15O16S
  • H donors: 17 H acceptors: 16 LogP: -7.35 Rotable bonds: 49
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)O)CCCN=C(N)N)CC(C)C)CCC(=O)N)CCS)CC(=O)O)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)CO)Cc1ccccc1
  • InChi: 1S/C57H87N15O16S/c1-31(2)26-42(55(86)72-24-9-14-44(72)54(85)67-39(56(87)88)13-8-23-63-57(61)62)70-49(80)37(19-20-45(60)75)65-50(81)38(21-25-89)66-52(83)41(29-46(76)77)69-48(79)36(12-6-7-22-58)64-51(82)40(28-32-10-4-3-5-11-32)68-53(84)43(30-73)71-47(78)35(59)27-33-15-17-34(74)18-16-33/h3-5,10-11,15-18,31,35-44,73-74,89H,6-9,12-14,19-30,58-59H2,1-2H3,(H2,60,75)(H,64,82)(H,65,81)(H,66,83)(H,67,85)(H,68,84)(H,69,79)(H,70,80)(H,71,78)(H,76,77)(H,87,88)(H4,61,62,63)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
  • InChiKey: LFABMKHGKDYYLZ-BLDAPKAQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0427 0.0857 0.8719
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0015 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0846 0.1724 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0194 0.0374 0.0373
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0253 0.0494 0.0494
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0098 0.0272
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0037 0.0139
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0194 0.0374 0.2119
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0017 0.0099
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.001 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0625 0.1267 0.7334
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0369 0.1398
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Loa Loa (eye worm) hypothetical protein 0.0278 0.0548 0.2339
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.3738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0571 0.327
Schistosoma mansoni hypothetical protein 0.0082 0.014 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Leishmania major phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.0497
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0075
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0104 0.0186 0.199
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.1724 0.4992
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0035
Echinococcus granulosus casein kinase ii subunit alpha 0.0137 0.0255 0.0255
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0702 0.1426 0.8262
Loa Loa (eye worm) RecQ helicase 0.0021 0.0015 0.0061
Schistosoma mansoni single-minded 0.0049 0.0072 0.027
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0156 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0051 0.0077 0.0199
Schistosoma mansoni hypothetical protein 0.0169 0.032 0.1212
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0104 0.0186 0.0702
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0234 0.0456 0.1313
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.001 0.001
Schistosoma mansoni lamin 0.0027 0.0026 0.0098
Brugia malayi hypothetical protein 0.0101 0.018 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0082 0.0417
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Brugia malayi hypoxia-induced factor 1 0.0151 0.0284 0.1644
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.0639 0.2419
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0057 0.0154
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0015 0.0024
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0338 0.0671 0.6809
Giardia lamblia Hypothetical protein 0.0104 0.0186 0.1622
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Giardia lamblia Kinase, PLK 0.0192 0.0369 0.3557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.001 0.001
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0179 0.0342 0.1461
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0438 0.0879 0.8949
Trypanosoma brucei polo-like protein kinase 0.0192 0.0369 0.3695
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0015 0.0024
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0077 0.0076
Brugia malayi Pre-SET motif family protein 0.0207 0.04 0.232
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Giardia lamblia Phosphatidylinositol 4-kinase 0.0104 0.0186 0.1622
Leishmania major hypothetical protein, conserved 0.1781 0.3665 1
Schistosoma mansoni hypothetical protein 0.0104 0.0186 0.0702
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0194 0.0374 0.2165
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0032 0.0032
Onchocerca volvulus 0.0236 0.046 0.7196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0186 0.1075
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0047 0.103
Mycobacterium leprae conserved hypothetical protein 0.0104 0.0186 0.9407
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.018 0.104
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0194 0.0374 1
Onchocerca volvulus 0.0041 0.0056 0.0866
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0137 0.0255 0.1089
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0171 0.0936
Schistosoma mansoni hypothetical protein 0.0051 0.0077 0.0291
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0104 0.0186 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0224 0.1245
Brugia malayi hypothetical protein 0.0019 0.001 0.0058
Echinococcus granulosus tumor protein p63 0.0339 0.0674 0.0673
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0284 0.121
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.0528
Mycobacterium ulcerans putative regulatory protein 0.002 0.0011 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0487 0.0981 0.2669
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0051 0.0077 0.0821
Echinococcus multilocularis 0.0104 0.0186 0.0185
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Onchocerca volvulus 0.0027 0.0026 0.0404
Schistosoma mansoni kinase 0.0099 0.0176 0.0665
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.007 0.0297
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0267 0.0525 0.3002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0077 0.0076
Brugia malayi PAS domain containing protein 0.0049 0.0072 0.0414
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0037 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Schistosoma mansoni lamin 0.0027 0.0026 0.0098
Onchocerca volvulus 0.005 0.0073 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Loa Loa (eye worm) hypothetical protein 0.0253 0.0494 0.211
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1287 0.264 0.2639
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0194 0.0374 0.2119
Brugia malayi Protein kinase domain containing protein 0.0018 0.0008 0.0041
Plasmodium vivax glycogen synthase kinase 3, putative 0.0051 0.0077 0.2043
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0005 0.0018
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0027 0.0152
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0151 0.015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.083 0.4784
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0124 0.0123
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0104 0.0186 0.1023
Loa Loa (eye worm) RGS-3 protein 0.0019 0.001 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0077 0.0386
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0047 0.0046
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.0061
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0482 0.0969 0.9878
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0487 0.0981 0.5664
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0037 0.0037
Toxoplasma gondii ck2 beta subunit 0.0037 0.0047 0.0501
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0197 0.0196
Echinococcus multilocularis casein kinase ii subunit alpha 0.0137 0.0255 0.0255
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0175 0.0333 0.0332
Toxoplasma gondii FATC domain-containing protein 0.0267 0.0525 0.5625
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.0639 0.0638
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.1073
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus multilocularis expressed protein 0.0374 0.0747 0.0747
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.0639 0.2727
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.1802
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0338 0.0671 0.1937
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0478 0.0961 0.5575
Brugia malayi hypothetical protein 0.0164 0.031 0.1797
Echinococcus granulosus bloom syndrome protein 0.0021 0.0015 0.0014
Echinococcus multilocularis survival motor neuron protein 1 0.0473 0.0951 0.095
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0442 0.0886 0.5138
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus multilocularis lamin dm0 0.0027 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0082 0.0417
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.001 0.0043
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.001 0.001
Brugia malayi SH2 domain containing protein 0.0341 0.0678 0.393
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0767
Plasmodium vivax hypothetical protein, conserved 0.002 0.0011 0.0285
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0032 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi Pre-SET motif family protein 0.003 0.0032 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0494 0.2824
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.04 0.1708
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Giardia lamblia GTOR 0.0487 0.0981 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0194 0.0374 0.101
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0047 0.0212
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0197 0.0838
Echinococcus granulosus geminin 0.0169 0.032 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0981 0.5664
Echinococcus multilocularis lamin 0.0027 0.0026 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0077 0.0288
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0255 0.143
Onchocerca volvulus 0.0051 0.0077 0.1193
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0197 0.1915
Plasmodium vivax hypothetical protein 0.0104 0.0186 0.4966
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0333 0.1882
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0197 0.0743
Loa Loa (eye worm) hypothetical protein 0.0164 0.031 0.1323
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0023
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0047 0.0725
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0011 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0846 0.1724 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0027 0.0026
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0386 0.0771 0.2918
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0104 0.0186 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5161
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.003 0.0029
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.0639 0.3704
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Brugia malayi Casein kinase II, alpha chain 0.0137 0.0255 0.148
Schistosoma mansoni hypothetical protein 0.0169 0.032 0.1212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0487 0.0981 0.5689
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0487 0.0981 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Leishmania major phosphatidylinositol 3-kinase, putative 0.0427 0.0857 0.233
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0253 0.0494 0.1424
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0038
Onchocerca volvulus 0.0101 0.018 0.2807
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0156 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0278 0.0548 0.5873
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.001 0.0038
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0118 0.0216 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0571 0.327
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0037 0.0037
Loa Loa (eye worm) phosphatidylinositol kinase 0.0104 0.0186 0.0791
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0369 0.1061
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0047 0.0124
Loa Loa (eye worm) hypothetical protein 0.0604 0.1223 0.522
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Onchocerca volvulus Serine\/threonine kinase homolog 0.0192 0.0369 0.5778
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0104 0.0186 0.4843
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0026 0.011
Onchocerca volvulus 0.0104 0.0186 0.2901
Toxoplasma gondii GAF domain-containing protein 0.002 0.0011 0.0118
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0197 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.001 0.001
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0047 0.0501
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0297 0.0586 0.5931
Toxoplasma gondii hypothetical protein 0.0054 0.0082 0.0878
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.001
Schistosoma mansoni survival motor neuron protein 0.0096 0.017 0.0644
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0077 0.0386
Echinococcus granulosus expressed protein 0.0374 0.0747 0.0747
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0098 0.0097
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0045 0.0045
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0112
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0047 0.1244
Onchocerca volvulus 0.0027 0.0026 0.0404
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0194 0.0374 0.1413
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0194 0.0374 0.2119
Loa Loa (eye worm) phosphatidylinositol 3 0.0487 0.0981 0.4188
Brugia malayi Cytochrome P450 family protein 0.003 0.0032 0.0185
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0186 0.9407
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0469 0.0943 0.9607
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0045 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.1678 0.345 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0073 0.0277
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0469 0.0943 0.2565
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0045 0.1861
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.001 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0104 0.0186 0.1023
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0478 0.0961 0.3641
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0197 0.1087
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0104 0.0186 0.0528
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.001 0.001
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0047 0.0175
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0438 0.0879 0.2391
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0179 0.0342 0.1984
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0197 0.0838
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0478 0.0961 0.2779
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0194 0.0374 0.1413
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0017 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5161
Entamoeba histolytica protein kinase rad3, putative 0.0253 0.0494 0.2824
Echinococcus multilocularis serine protein kinase ATM 0.0267 0.0525 0.0524
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0194 0.0374 0.2119
Echinococcus granulosus expressed conserved protein 0.0082 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0175 0.0333 0.142
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0106
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0197 1
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0137 0.0255 0.6836
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0253 0.0494 0.2866
Trichomonas vaginalis PIKK family atypical protein kinase 0.0438 0.0879 0.5069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.0467 0.1993
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0 0.0000000077582
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0625 0.1267 0.7334
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0064
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0032 0.0615
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0124 0.0123
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0279 0.1569
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0077 0.0326
Entamoeba histolytica hypothetical protein 0.0267 0.0525 0.3002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0267 0.0525 0.3043
Brugia malayi 6-phosphofructokinase 0.0109 0.0197 0.1139
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0312
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0247 0.0484 0.476
Brugia malayi Serotonin receptor 0.047 0.0946 0.5484
Loa Loa (eye worm) hypothetical protein 0.0287 0.0567 0.2418
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0032 0.5
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0473 0.0951 0.4059
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0011 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0032 0.0136
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0118
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0487 0.0981 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0037 0.0037
Brugia malayi hypothetical protein 0.0473 0.0951 0.5513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.0517 0.2955
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0045 0.0262
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0478 0.0961 0.0961
Echinococcus granulosus intermediate filament protein 0.0027 0.0026 0.0026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0487 0.0981 0.5664
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0017 0.0073
Onchocerca volvulus 0.0101 0.018 0.2807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0186 0.1023
Leishmania major phosphatidylinositol kinase related protein, putative 0.0118 0.0216 0.058
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0037 0.0037
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0077 0.0473
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Echinococcus granulosus high voltage activated calcium channel beta 0.0087 0.0151 0.0151
Echinococcus multilocularis tumor protein p63 0.0339 0.0674 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.001
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0047 0.037
Brugia malayi phosphofructokinase 0.0109 0.0197 0.1139
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0846 0.1724 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0032 0.0345
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0047 0.0117
Plasmodium vivax unspecified product 0.0137 0.0255 0.6836
Echinococcus multilocularis expressed conserved protein 0.0082 0.014 0.014
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0032 0.0339
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0098 0.0893
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.4966
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0369 0.2094
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0197 0.0743
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0197 0.0838
Brugia malayi PXA domain containing protein 0.0021 0.0013 0.0075
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0032 0.0839
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0487 0.0981 0.2836
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0072 0.027
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0157
Brugia malayi hypothetical protein 0.0019 0.001 0.0058
Trypanosoma cruzi casein kinase II, putative 0.0137 0.0255 0.073
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.4966
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0047 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0064
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0077 0.0326
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0104 0.0186 0.0185
Brugia malayi FAT domain containing protein 0.0175 0.0333 0.1929
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.0061
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0038
Entamoeba histolytica casein kinase, putative 0.0137 0.0255 0.143
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0104 0.0186 0.1023
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0194 0.0374 0.0373
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.1724 0.4992
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0156 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0098 0.0508
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0077 0.0473
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0027 0.0094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0104 0.0186 0.199
Brugia malayi intracellular kinase 0.0051 0.0077 0.0442
Plasmodium vivax SET domain protein, putative 0.003 0.0032 0.0853
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0047 0.103
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0267 0.0525 0.1987
Brugia malayi hypothetical protein 0.0036 0.0045 0.0261
Echinococcus granulosus survival motor neuron protein 1 0.0473 0.0951 0.095
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0197 1
Onchocerca volvulus 0.0096 0.017 0.2663
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0098 0.0097
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0037 0.0214
Plasmodium falciparum glycogen synthase kinase 3 0.0051 0.0077 0.1849
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.001 0.0058
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0338 0.0671 0.3857
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0263 0.0517 0.2955
Leishmania major cytochrome p450-like protein 0.0019 0.0011 0.0019
Toxoplasma gondii target of rapamycin (TOR), putative 0.0464 0.0933 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0846 0.1724 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.002
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0197 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.045 0.0905 0.5218
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0338 0.0671 0.3857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.0619 0.355
Schistosoma mansoni hypothetical protein 0.0036 0.0045 0.017
Entamoeba histolytica hypothetical protein 0.0104 0.0186 0.1023
Trypanosoma brucei Casein kinase II 0.0137 0.0255 0.2521
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0104 0.0186 0.4966
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0766
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0104 0.0186 0.0528
Loa Loa (eye worm) hypothetical protein 0.0104 0.0186 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0194 0.0374 0.0373
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0032 0.0124
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0194 0.0374 0.2119
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0104 0.0186 0.199
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.0639 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0032 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0037 0.0037
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0253 0.0494 0.0494
Echinococcus granulosus protein kinase shaggy 0.0051 0.0077 0.0076
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0038
Brugia malayi follicle stimulating hormone receptor 0.0239 0.0467 0.2708
Entamoeba histolytica hypothetical protein 0.0702 0.1426 0.8262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.012
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0456 0.1947
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0098 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0606 0.1228 0.7119
Echinococcus multilocularis geminin 0.0169 0.032 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5161
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0487 0.0981 0.3715
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0487 0.0981 0.0981
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0338 0.0671 0.3857
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0338 0.0671 0.3857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Brugia malayi Protein kinase domain containing protein 0.0134 0.0249 0.1442
Onchocerca volvulus 0.0104 0.0186 0.2901
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0164 0.031 0.0888
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.1658 0.1657
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0156 0.059
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0047 0.0212
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0192 0.0369 0.0369
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0057 0.0272
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0197 0.1087
Loa Loa (eye worm) hypothetical protein 0.0341 0.0678 0.2893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0981 0.5664
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0087 0.0151 0.057
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0027 0.0099
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0026 0.011
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0487 0.0981 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0194 0.0374 0.4003
Schistosoma mansoni protein kinase 0.0137 0.0255 0.0966
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0267 0.0525 0.5298
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0032 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.0634 0.3639
Toxoplasma gondii CMGC kinase, CK2 family 0.0137 0.0255 0.2738
Trypanosoma cruzi target of rapamycin kinase 3 0.0469 0.0943 0.2725
Echinococcus granulosus lamin dm0 0.0027 0.0026 0.0026
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0051 0.0077 0.0211
Leishmania major casein kinase II, putative 0.0137 0.0255 0.0687
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0141 0.0262 0.2589
Trichomonas vaginalis conserved hypothetical protein 0.0278 0.0548 0.3137
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.1073
Echinococcus granulosus cyclin dependent kinase 19 0.0134 0.0249 0.0248
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0197 0.1087
Onchocerca volvulus 0.0036 0.0045 0.0705
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0933 0.5384
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0037 0.0037
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0032 0.0339
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0104 0.0186 0.0185
Leishmania major phosphatidylinositol kinase, putative 0.0104 0.0186 0.0497
Entamoeba histolytica serine/threonine protein kinase, putative 0.0192 0.0369 0.2094
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0186 0.4966
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.0098 0.0368
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0895 0.5162
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1287 0.264 0.2639
Mycobacterium ulcerans putative regulatory protein 0.002 0.0011 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0438 0.0879 0.3753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Loa Loa (eye worm) calcium channel 0.0032 0.0037 0.0157
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0151 0.015
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0032 0.0339
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0104 0.0186 0.1802
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0192 0.0369 0.1576
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0017 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0487 0.0981 0.2836
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0124
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0846 0.1724 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0098 0.0893
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0047 0.1244
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.0639 0.0638
Echinococcus multilocularis cyclin dependent kinase 19 0.0134 0.0249 0.0248
Brugia malayi Protein kinase domain containing protein 0.0322 0.0639 0.3704
Plasmodium falciparum casein kinase 2, alpha subunit 0.0137 0.0255 0.6759
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi intermediate filament protein 0.0027 0.0026 0.015
Echinococcus multilocularis high voltage activated calcium channel beta 0.0087 0.0151 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0017 0.0064
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Brugia malayi serine/threonine-protein kinase plk-2 0.0192 0.0369 0.214
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0194 0.0374 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.001 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0384 0.0766 0.4408
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Echinococcus granulosus lamin 0.0027 0.0026 0.0026
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.012
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0037 0.0037
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0175 0.0333 0.0332
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0047 0.0046
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0487 0.0981 0.2669
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.001 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0338 0.0671 0.3893
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0056 0.0209
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0098 0.0272
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0478 0.0961 0.0961
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0478 0.0961 0.2779
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0192 0.0369 0.0998
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0104 0.0186 0.4843
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0186 0.1075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0427 0.0857 0.4939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.0045
Entamoeba histolytica hypothetical protein 0.0036 0.0045 0.0204
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0194 0.0374 0.101
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0015 0.0083
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0098 0.0508
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0 0.0000000077582
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.045 0.0905 0.5218
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0077 0.0386
Entamoeba histolytica hypothetical protein 0.0104 0.0186 0.1023
Giardia lamblia Kinase, CMGC CK2 0.0137 0.0255 0.2357
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.001 0.001
Echinococcus granulosus single minded 2 0.0036 0.0045 0.0045
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0104 0.0186 0.0528
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0011 0.0045
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Schistosoma mansoni hypothetical protein 0.0096 0.017 0.0644
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.001 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0197 0.1087
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0047 0.0212
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0194 0.0374 0.0373
Loa Loa (eye worm) gastrulation defective protein 1 0.0131 0.0242 0.1031
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0027 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0279 0.1569
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0186 0.1023
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0171 0.0936
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0045 0.0045
Schistosoma mansoni ankyrin 23/unc44 0.0014 0 0.000000029393
Schistosoma mansoni hypothetical protein 0.0175 0.0333 0.1259
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0082 0.0417
Trichomonas vaginalis set domain proteins, putative 0.0236 0.046 0.2621
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0197 0.056
Trypanosoma brucei protein kinase, putative 0.0051 0.0077 0.0677
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0043
Entamoeba histolytica protein kinase, putative 0.0051 0.0077 0.0386
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0037 0.0037
Brugia malayi Csnk2b protein 0.0037 0.0047 0.0269
Echinococcus granulosus serine protein kinase ATM 0.0267 0.0525 0.0524
Loa Loa (eye worm) phosphatidylinositol 3 0.1143 0.2342 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0604 0.1223 0.1222
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0032 0.0124
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0077 0.0076
Schistosoma mansoni fkbp-rapamycin associated protein 0.0253 0.0494 0.1872
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0197 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.0571 0.327
Giardia lamblia Casein kinase II beta chain 0.0037 0.0047 0.0159
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0037 0.0139
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.0045
Entamoeba histolytica hypothetical protein 0.0104 0.0186 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0943 0.5441
Echinococcus multilocularis musashi 0.0027 0.0026 0.0026
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0267 0.0525 0.1512
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0027 0.0094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0194 0.0374 0.4003
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1287 0.264 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0047 0.0212
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0013 0.0056
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.002
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.0639 0.2727
Schistosoma mansoni intermediate filament proteins 0.0027 0.0026 0.0098
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0192 0.0369 0.0369
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0604 0.1223 0.1222
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0369 0.1061
Brugia malayi 6-phosphofructokinase 0.0109 0.0197 0.1139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.017 0.0987
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0255 0.143
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0047 0.0725
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0032 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0981 0.5664
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0057 0.0272
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0026 0.015
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0742 0.1509 0.8745
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.001
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0037 0.0139
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0098 0.0508
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0186 0.1075
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0294 0.0581 0.3326
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0027 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0249 0.0941
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0186 0.0791
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4836 1 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.031 0.1321
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0047 0.0124
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0197 0.0196
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0134 0.0249 0.1061
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.001
Leishmania major hypothetical protein, unknown function 0.0104 0.0186 0.0497
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0077 0.0386
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0194 0.0374 0.1594

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 1000 uM Effective dose required for smooth muscle contraction in human fetal artery ChEMBL. 7932541
pD2 (binding) < 3 Pharmacological activity against C5a receptor in human fetal artery ChEMBL. 7932541
Platelet aggregation (functional) = 225 uM Platelet aggregation in guinea pig ChEMBL. 7932541

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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