Detailed information for compound 402307

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 922.068 | Formula: C49H67N3O14
  • H donors: 3 H acceptors: 6 LogP: 2.55 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(nc1)[C@@H]([C@H](C(=O)O[C@H]1C[C@@]2(O)[C@@H](OCc3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4CC[C@]3([C@H]3[C@@H](C(=C1C)C2(C)C)O[C@H](O3)CN1CCOCC1)C)OC(=O)C)O)NC(=O)OC(C)(C)C
  • InChi: 1S/C49H67N3O14/c1-28-33(62-43(55)38(54)37(51-44(56)66-45(3,4)5)32-16-15-31(58-9)24-50-32)23-49(57)42(60-26-30-13-11-10-12-14-30)40-47(8,18-17-34-48(40,27-61-34)65-29(2)53)41-39(36(28)46(49,6)7)63-35(64-41)25-52-19-21-59-22-20-52/h10-16,24,33-35,37-42,54,57H,17-23,25-27H2,1-9H3,(H,51,56)/t33-,34+,35+,37-,38+,39+,40-,41+,42-,47+,48-,49+/m0/s1
  • InChiKey: JYDOEUIWXYWXBR-QJCWKBPNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0261 0.0279 0.1885
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0048 0.0036 0.0096
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0166 0.1119
Echinococcus multilocularis survival motor neuron protein 1 0.0539 0.0596 0.0596
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0433 0.0475 0.1364
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0098 0.0587
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0123 0.0331
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0203 0.0214 0.2384
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0166 0.0165
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0928 0.104 0.104
Brugia malayi SH2 domain containing protein 0.0389 0.0425 0.3839
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.002 0.0235
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0016 0.0146
Schistosoma mansoni lamin 0.0031 0.0016 0.0097
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0772 0.0862 0.0862
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0263 0.0281 1
Entamoeba histolytica hypothetical protein 0.0161 0.0166 0.1446
Echinococcus multilocularis expressed protein 0.0427 0.0469 0.0469
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0161 0.0166 0.0165
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0772 0.0862 0.2481
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0061 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0463 0.051 0.4572
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0099 0.0095 0.0569
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0061 0.0496
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0161 0.0166 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.0166 0.1446
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0029 0.0256
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0456 0.4082
Leishmania major phosphatidylinositol kinase related protein, putative 0.0178 0.0185 0.05
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0263 0.0281 0.2494
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.002 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0061 0.0169
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0123 0.1062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0811 0.7302
Echinococcus multilocularis voltage dependent calcium channel 0.0037 0.0023 0.0023
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.0048 0.0125
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0166 0.1963
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0741 0.0827 0.7448
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0007 0.0006
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1472 0.1661 0.166
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.0797 0.7175
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0007 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.0797 0.7175
Plasmodium falciparum casein kinase 2, alpha subunit 0.0157 0.016 0.5611
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0263 0.0281 0.0804
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Loa Loa (eye worm) gastrulation defective protein 1 0.0149 0.0152 0.1025
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0157 0.016 0.1083
Onchocerca volvulus 0.0161 0.0166 0.413
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0029 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.002 0.0121
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0161 0.0166 0.0471
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0433 0.0475 0.2859
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0726 0.0811 0.9263
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0007 0.0006
Echinococcus granulosus expressed protein 0.0427 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0115 0.0113 0.076
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus granulosus casein kinase ii subunit alpha 0.0157 0.016 0.016
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0719 0.0801 0.0801
Toxoplasma gondii CMGC kinase, CK2 family 0.0157 0.016 0.1899
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0156 0.0939
Echinococcus multilocularis voltage dependent calcium channel 0.0037 0.0023 0.0023
Brugia malayi Protein kinase domain containing protein 0.0367 0.0401 0.3618
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0048 0.0377
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.002 0.0121
Entamoeba histolytica hypothetical protein 0.0827 0.0926 0.8347
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.002 0.0235
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0161 0.0166 0.1832
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0007 0.0045
Schistosoma mansoni hypothetical protein 0.0298 0.0322 0.1938
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.002 0.0121
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0263 0.0281 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0428 0.047 0.4209
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0263 0.0281 0.0281
Brugia malayi 6-phosphofructokinase 0.0124 0.0123 0.1113
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0721 0.0804 0.7263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0458 0.0504 0.4517
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0783 0.0874 0.2516
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0772 0.0862 0.5191
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0298 0.0322 0.0322
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0783 0.0874 0.5265
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0204 0.0215 0.1938
Entamoeba histolytica protein kinase, putative 0.0058 0.0048 0.0377
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0153 0.0156 0.1055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0007 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0161 0.0166 0.5892
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0219 0.0232 0.0231
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0045
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Brugia malayi hypoxia-induced factor 1 0.0172 0.0178 0.1606
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0123 0.0349
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0007 0.0013
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0037 0.0023 0.0023
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0042 0.0029 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0011 0.0064
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0123 0.0833
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0048 0.033
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.002 0.002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0987 0.1108 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0042 0.0029 0.0078
Trypanosoma cruzi casein kinase II, putative 0.0157 0.016 0.0456
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0263 0.0281 0.1692
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0031 0.0017 0.0016
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.0048 0.0132
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0098 0.0587
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.085 0.7665
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0166 0.0165
Loa Loa (eye worm) hypothetical protein 0.0389 0.0425 0.2875
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0042 0.0029 0.026
Echinococcus granulosus single minded 2 0.0041 0.0029 0.0028
Toxoplasma gondii non-specific serine/threonine protein kinase 0.046 0.0506 0.5996
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.082 0.7392
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0987 0.1108 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0367 0.0401 0.3618
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0107 0.0914
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.007 0.0061 0.0061
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0007 0.0038
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0037 0.0023 0.0023
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.0048 0.057
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0772 0.0862 0.2481
Brugia malayi intermediate filament protein 0.0031 0.0016 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.085 0.7665
Brugia malayi hypothetical protein 0.0115 0.0113 0.1016
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0026 0.0011 0.0073
Onchocerca volvulus 0.0041 0.0029 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Echinococcus multilocularis tumor protein p63 0.0387 0.0423 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.046 0.0506 0.4539
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0099 0.0095 0.0094
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.002 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0719 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0043
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0029 0.1861
Brugia malayi phosphofructokinase 0.0124 0.0123 0.1113
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0166 0.1119
Brugia malayi intracellular kinase 0.0058 0.0048 0.0432
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0037 0.0023 0.0023
Echinococcus multilocularis expressed conserved protein 0.0093 0.0088 0.0088
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0166 0.0165
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0123 0.7336
Schistosoma mansoni casein kinase II beta subunit 0.0042 0.0029 0.0175
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.002 0.0121
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0161 0.0166 0.0471
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0042 0.0029 0.0207
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.002 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0987 0.1108 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.002 0.012
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0783 0.0874 0.2389
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.0045 0.0269
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.006
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0219 0.0232 0.1566
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0009 0.0024
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0161 0.0166 0.5892
Giardia lamblia Hypothetical protein 0.0161 0.0166 0.1707
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0261 0.0279 0.0798
Giardia lamblia GTOR 0.0783 0.0874 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0254 0.0272 0.2409
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0007 0.0038
Brugia malayi PXA domain containing protein 0.0024 0.0008 0.0074
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0428 0.047 0.4209
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0031 0.0017 0.0016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0178 0.0185 0.0526
Plasmodium vivax casein kinase II beta chain, putative 0.0042 0.0029 0.1037
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.002 0.0121
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0123 0.1344
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0166 0.1963
Schistosoma mansoni hypothetical protein 0.011 0.0107 0.0642
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0422 0.0463 0.4147
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0123 0.1062
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0161 0.0166 0.1446
Onchocerca volvulus 0.0031 0.0016 0.0403
Echinococcus granulosus geminin 0.0192 0.0201 0.0201
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0123 0.0833
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.878 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0772 0.0862 0.0862
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0007 0.0038
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0037 0.0023 0.0139
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0048 0.0036 0.0266
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus granulosus lamin 0.0031 0.0016 0.0016
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0827 0.0926 0.8347
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0263 0.0281 1
Toxoplasma gondii hypothetical protein 0.0022 0.0007 0.0082
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0161 0.0166 0.0471
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0161 0.0166 0.5808
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0048 0.0324
Entamoeba histolytica casein kinase, putative 0.0157 0.016 0.1396
Echinococcus multilocularis lamin dm0 0.0031 0.0016 0.0016
Toxoplasma gondii hypothetical protein 0.0061 0.0051 0.0609
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0298 0.0322 0.0322
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0 0.0000000048638
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Brugia malayi hypothetical protein 0.0187 0.0195 0.1755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.0166 0.1446
Brugia malayi follicle stimulating hormone receptor 0.027 0.029 0.2618
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0031 0.0017 0.0149
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0123 0.0123
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0007 0.0038
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0007 0.0006
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Entamoeba histolytica hypothetical protein 0.0041 0.0029 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0107 0.0914
Schistosoma mansoni fkbp-rapamycin associated protein 0.0416 0.0456 0.2744
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Loa Loa (eye worm) phosphatidylinositol 3 0.1312 0.1479 1
Echinococcus granulosus protein kinase shaggy 0.0058 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0007 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0048 0.0377
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.0166 0.1446
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0037 0.0023 0.0023
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0 0.0000000048638
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0037 0.0023 0.0023
Plasmodium vivax casein kinase II beta chain, putative 0.0042 0.0029 0.1037
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.007 0.0061 0.0367
Brugia malayi hypothetical protein 0.0022 0.0007 0.0057
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0367 0.0401 0.271
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0783 0.0874 0.2389
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.0048 0.1704
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.002 0.002
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0161 0.0166 0.0996
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0422 0.0463 0.4147
Echinococcus granulosus lamin dm0 0.0031 0.0016 0.0016
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0263 0.0281 0.2494
Brugia malayi Csnk2b protein 0.0042 0.0029 0.0263
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1472 0.1661 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0742 0.0829 0.7466
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.011
Schistosoma mansoni protein kinase 0.0157 0.016 0.0964
Loa Loa (eye worm) hypothetical protein 0.0416 0.0456 0.3082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0035 0.0208
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0783 0.0874 0.7895
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0007 0.0239
Entamoeba histolytica hypothetical protein 0.0433 0.0475 0.4255
Plasmodium falciparum GAF domain-related protein, putative 0.0022 0.0007 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0123 0.1062
Loa Loa (eye worm) hypothetical protein 0.0539 0.0596 0.4031
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0742 0.0829 0.7466
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0762 0.0851 0.2324
Mycobacterium leprae conserved hypothetical protein 0.0161 0.0166 1
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0232 0.1394
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0762 0.0851 0.9724
Brugia malayi 6-phosphofructokinase 0.0124 0.0123 0.1113
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus multilocularis 0.0161 0.0166 0.0165
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.0726 0.0811 0.548
Onchocerca volvulus 0.0058 0.0048 0.1193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0 0.0001
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0263 0.0281 0.0764
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0007 0.0006
Entamoeba histolytica hypothetical protein 0.0041 0.0029 0.0199
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0009 0.0024
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0007 0.0038
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0161 0.0166 0.0996
Entamoeba histolytica hypothetical protein 0.0041 0.0029 0.0199
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0157 0.016 0.5698
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0166 0.1495
Leishmania major casein kinase II, putative 0.0157 0.016 0.0433
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0007 0.0006
Schistosoma mansoni survival motor neuron protein 0.011 0.0107 0.0642
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0042 0.0029 0.0078
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.002 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.0874 0.7883
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0099 0.0095 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.002 0.0121
Echinococcus multilocularis cyclin dependent kinase 19 0.0153 0.0156 0.0156
Loa Loa (eye worm) calcium channel 0.0037 0.0023 0.0157
Echinococcus multilocularis beta adrenergic receptor kinase 0.0026 0.0011 0.0011
Toxoplasma gondii FATC domain-containing protein 0.0433 0.0475 0.5626
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0433 0.0475 0.4288
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0166 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0987 0.1108 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Onchocerca volvulus Serine\/threonine kinase homolog 0.0219 0.0232 0.5778
Echinococcus multilocularis casein kinase ii subunit beta 0.0042 0.0029 0.0029
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0263 0.0281 0.2494
Echinococcus granulosus high voltage activated calcium channel beta 0.0099 0.0095 0.0094
Echinococcus multilocularis lamin 0.0031 0.0016 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0011 0.0064
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0161 0.0166 0.5892
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0031 0.0017 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Echinococcus granulosus casein kinase ii subunit beta 0.0042 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0157
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.002 0.0235
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.0534 0.479
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus granulosus voltage dependent calcium channel 0.0037 0.0023 0.0023
Entamoeba histolytica protein kinase rad3, putative 0.0416 0.0456 0.4082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0433 0.0475 0.4255
Giardia lamblia Phosphatidylinositol 4-kinase 0.0161 0.0166 0.1707
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0042 0.0029 0.0207
Entamoeba histolytica hypothetical protein 0.0161 0.0166 0.1446
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0219 0.0232 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.085 0.7665
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0783 0.0874 0.7883
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.002 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.085 0.7665
Echinococcus multilocularis geminin 0.0192 0.0201 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0458 0.0504 0.4517
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0481 0.053 0.6033
Trichomonas vaginalis set domain proteins, putative 0.0269 0.0288 0.2557
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus granulosus cyclin dependent kinase 19 0.0153 0.0156 0.0156
Echinococcus granulosus serine protein kinase ATM 0.0433 0.0475 0.0475
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0007 0.0006
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.007 0.0061 0.0061
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0007 0.0057
Leishmania major hypothetical protein, unknown function 0.0161 0.0166 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0009 0.0081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0166 0.1495
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0714 0.0797 0.9101
Brugia malayi hypothetical protein 0.0041 0.0029 0.0255
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0161 0.0166 0.5808
Brugia malayi Cytochrome P450 family protein 0.0034 0.002 0.0181
Trypanosoma cruzi polo-like protein kinase, putative 0.0219 0.0232 0.0662
Brugia malayi M-phase phosphoprotein, mpp8 0.0115 0.0113 0.1015
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0007 0.0006
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0031 0.0017 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0474 0.0522 0.4685
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0051 0.0407
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.0821 0.7393
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0061 0.0496
Plasmodium vivax unspecified product 0.0157 0.016 0.5698
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0031 0.0017 0.0092
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0772 0.0862 0.7784
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0007 0.0007
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.0048 0.0048
Schistosoma mansoni kinase 0.0113 0.0111 0.0664
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.046 0.0506 0.3423
Schistosoma mansoni hypothetical protein 0.0192 0.0201 0.1208
Brugia malayi Casein kinase II, alpha chain 0.0157 0.016 0.1446
Schistosoma mansoni single-minded 0.0056 0.0045 0.0269
Brugia malayi Death domain containing protein 0.0016 0 0.0001
Toxoplasma gondii ck2 beta subunit 0.0042 0.0029 0.0348
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0037 0.0023 0.0139
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0061 0.0169
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0055 0.0044 0.0295
Echinococcus granulosus tumor protein p63 0.0387 0.0423 0.0422
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0007 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0048 0.0377
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1472 0.1661 0.166
Toxoplasma gondii target of rapamycin (TOR), putative 0.0756 0.0844 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0367 0.0401 0.0401
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0048 0.0377
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.029 0.1961
Onchocerca volvulus 0.0057 0.0046 0.1143
Echinococcus multilocularis musashi 0.0031 0.0016 0.0016
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0007 0.0043
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0048 0.0324
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0123 0.1062
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0007 0.0038
Schistosoma mansoni intermediate filament proteins 0.0031 0.0016 0.0097
Echinococcus multilocularis high voltage activated calcium channel beta 0.0099 0.0095 0.0094
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0078 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0507 0.056 0.5029
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0051 0.0407
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0048 0.0036 0.0266
Loa Loa (eye worm) hypothetical protein 0.0187 0.0195 0.1315
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0433 0.0475 0.5397
Plasmodium falciparum casein kinase II beta chain 0.0042 0.0029 0.0856
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Brugia malayi FAT domain containing protein 0.0298 0.0322 0.2906
Brugia malayi Uncoordinated protein 44 0.0016 0 0.0001
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Onchocerca volvulus 0.0115 0.0113 0.2803
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0007 0.0006
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0031 0.0017 0.0149
Brugia malayi Pre-SET motif family protein 0.0236 0.0251 0.2263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.082 0.7392
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0219 0.0232 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.0797 0.7175
Entamoeba histolytica serine/threonine protein kinase, putative 0.0219 0.0232 0.2045
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0007 0.0038
Brugia malayi PXA domain containing protein 0.0024 0.0008 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0458 0.0504 0.4517
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0045
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0263 0.0281 0.2494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.0821 0.7393
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.002 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0298 0.0322 0.2866
Schistosoma mansoni hypothetical protein 0.0059 0.0048 0.029
Echinococcus granulosus bloom syndrome protein 0.0024 0.0009 0.0009
Leishmania major hypothetical protein, conserved 0.3217 0.3652 1
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0271 0.0291 0.0832
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0022 0.0007 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0157 0.016 0.1396
Onchocerca volvulus 0.011 0.0107 0.2662
Echinococcus multilocularis protein kinase shaggy 0.0058 0.0048 0.0048
Brugia malayi Protein kinase domain containing protein 0.0153 0.0156 0.1408
Onchocerca volvulus 0.0161 0.0166 0.413
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0123 0.0123
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0123 0.0833
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Loa Loa (eye worm) hypothetical protein 0.0161 0.0166 0.1119
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0263 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0115 0.0113 0.0761
Onchocerca volvulus 0.0047 0.0035 0.0864
Schistosoma mansoni voltage-gated cation channel 0.0037 0.0023 0.0139
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0263 0.0281 0.0281
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0061 0.0496
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0123 0.0742
Plasmodium vivax SET domain protein, putative 0.0034 0.002 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.0401 0.2413
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0987 0.1108 0.3189
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0263 0.0281 0.2537
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0123 0.1062
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0507 0.056 0.5029
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0009 0.0009
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0263 0.0281 0.2494
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.017
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0026 0.0011 0.0073
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0007 0.0057
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0166 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.0874 0.7883
Brugia malayi hypothetical protein 0.0022 0.0007 0.0057
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0987 0.1108 1
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0123 0.1062
Loa Loa (eye worm) PXA domain-containing protein 0.0024 0.0008 0.0055
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.002 0.07
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0263 0.0281 0.333
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0416 0.0456 0.0456
Onchocerca volvulus 0.0269 0.0288 0.7188
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0422 0.0463 0.4147
Echinococcus granulosus expressed conserved protein 0.0093 0.0088 0.0088
Trypanosoma brucei Casein kinase II 0.0157 0.016 0.1769
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.0048 0.0048
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0204 0.0215 0.1452
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0061 0.0496
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0161 0.0166 0.5892
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0825 0.0923 0.8327
Brugia malayi Protein kinase domain containing protein 0.002 0.0005 0.0041
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0102 0.0098 0.0098
Loa Loa (eye worm) RecQ helicase 0.0024 0.0009 0.006
Brugia malayi PAS domain containing protein 0.0056 0.0045 0.0405
Echinococcus granulosus survival motor neuron protein 1 0.0539 0.0596 0.0596
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0583 0.0647 0.7333
Brugia malayi hypothetical protein 0.0539 0.0596 0.5382
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0161 0.0166 0.0996
Giardia lamblia Kinase, PLK 0.0219 0.0232 0.2479
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0105
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0367 0.0401 0.0401
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0161 0.0166 0.1446
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0011 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Loa Loa (eye worm) hypothetical protein 0.0298 0.0322 0.2177
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0061 0.0169
Schistosoma mansoni ankyrin 23/unc44 0.0016 0 0.000000029293
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.0135
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0783 0.0874 0.0874
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0166 0.1119
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0046 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.019 0.1663
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0019 0.0018
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0078 0.0077
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0007 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0416 0.0456 0.0456
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0042 0.0029 0.0725
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0048 0.033
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0007 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0416 0.0456 0.4116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.082 0.7392
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0037 0.0023 0.0209
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0007 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.002 0.0121
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0783 0.0874 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0 0.0001
Leishmania major cytochrome p450-like protein 0.0022 0.0007 0.0012
Brugia malayi Pre-SET motif family protein 0.0034 0.002 0.018
Loa Loa (eye worm) hypothetical protein 0.032 0.0347 0.2345
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0422 0.0463 0.5259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0007 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0029 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.002 0.012
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0263 0.0281 0.19
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0783 0.0874 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0741 0.0827 0.7448
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.002 0.0511
Giardia lamblia Kinase, CMGC CK2 0.0157 0.016 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0756 0.0844 0.761
Entamoeba histolytica hypothetical protein 0.0041 0.0029 0.0199
Leishmania major phosphatidylinositol 4-kinase, putative 0.0161 0.0166 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0007 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.3055 0.3468 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0007 0.0057
Loa Loa (eye worm) hypothetical protein 0.0057 0.0046 0.031
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.016 0.1396
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0007 0.0038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0042 0.0029 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.085 0.7665
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0166 0.1119
Echinococcus multilocularis Zinc finger, PHD finger 0.0263 0.0281 0.0281
Echinococcus granulosus beta-adrenergic receptor kinase 0.0026 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0719 0.0801 0.5419
Schistosoma mansoni hypothetical protein 0.0093 0.0088 0.0528
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0367 0.0401 0.271
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0416 0.0456 0.1309
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0263 0.0281 0.1692
Leishmania major phosphatidylinositol kinase, putative 0.0161 0.0166 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.0797 0.7175
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Trypanosoma cruzi target of rapamycin kinase 3 0.0762 0.0851 0.2447
Leishmania major phosphatidylinositol 3-kinase, putative 0.0714 0.0797 0.2176
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0463 0.418
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0161 0.0166 0.1832
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0422 0.0463 0.1329
Plasmodium vivax hypothetical protein 0.0161 0.0166 0.5892
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0007 0.0038
Brugia malayi Serotonin receptor 0.0534 0.059 0.5329
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0043
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0102 0.0098 0.0098
Onchocerca volvulus 0.0115 0.0113 0.2803
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0367 0.0401 1
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0123 0.1062
Loa Loa (eye worm) Csnk2b protein 0.0042 0.0029 0.0197
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0263 0.0281 0.3162
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0123 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0037 0.0023 0.0023
Toxoplasma gondii GAF domain-containing protein 0.0022 0.0007 0.0082
Brugia malayi serine/threonine-protein kinase plk-2 0.0219 0.0232 0.2091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0783 0.0874 0.2516
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0051 0.0407
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0029 0.0207
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0422 0.0463 0.4147
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.0048 0.1535
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0477 0.0525 0.3163
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0061 0.0496
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0007 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.011 0.0107 0.0963
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0007 0.0038
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0007 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0045
Onchocerca volvulus 0.0031 0.0016 0.0403
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0123 0.7336
Entamoeba histolytica hypothetical protein 0.0161 0.0166 0.1446
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0043
Schistosoma mansoni lamin 0.0031 0.0016 0.0097
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0263 0.0281 0.333
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0026 0.0011 0.0097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0016 0.011
Giardia lamblia Casein kinase II beta chain 0.0042 0.0029 0.0111
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0029 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.0874 0.7883
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0166 0.1495
Trypanosoma cruzi polo-like protein kinase, putative 0.0219 0.0232 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0254 0.0272 0.2409
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0031 0.0017 0.0099
Loa Loa (eye worm) hypothetical protein 0.0271 0.0291 0.1966
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.002 0.0136
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0321 0.0348 0.3836
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0029 0.017
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0061 0.0626
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0007 0.0006
Plasmodium falciparum casein kinase II beta chain 0.0042 0.0029 0.0856
Loa Loa (eye worm) phosphatidylinositol 3 0.0783 0.0874 0.5913
Leishmania major phosphatidylinositol 3-kinase, putative 0.0263 0.0281 0.0764
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0123 0.0742
Trypanosoma brucei polo-like protein kinase 0.0219 0.0232 0.2592
Schistosoma mansoni hypothetical protein 0.0161 0.0166 0.0996
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0037 0.0023 0.0023
Loa Loa (eye worm) phosphatidylinositol kinase 0.0161 0.0166 0.1119
Schistosoma mansoni hypothetical protein 0.0192 0.0201 0.1208
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.0048 0.0288
Trypanosoma brucei protein kinase, putative 0.0058 0.0048 0.0475
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0166 0.1963
Toxoplasma gondii hypothetical protein 0.0022 0.0007 0.0082
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.002 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.0821 0.7393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.0821 0.7393
Echinococcus multilocularis casein kinase ii subunit alpha 0.0157 0.016 0.016
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0123 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0016 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0016 0.011
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0485 0.0535 0.4826
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.002 0.0121
Echinococcus multilocularis serine protein kinase ATM 0.0433 0.0475 0.0475
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0251 0.1695
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0726 0.0811 0.2214
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0007 0.0006
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0042 0.0029 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0023
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0987 0.1108 0.3189
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0042 0.0029 0.0725
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0783 0.0874 1
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0232 0.2045
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0783 0.0874 0.7883
Loa Loa (eye worm) hypoxia-induced factor 1 0.0172 0.0178 0.1203

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5.9 mg kg-1 Effective dose of intravenously administered compound against B16 melanoma BL6 cells implanted into mice ChEMBL. 15149677
ED50 (functional) = 5.9 mg kg-1 Effective dose of intravenously administered compound against B16 melanoma BL6 cells implanted into mice ChEMBL. 15149677
ED50 (functional) = 13.3 mg kg-1 Effective dose of perorally administered compound against B16 melanoma BL6 cells implanted into mice ChEMBL. 15149677
ED50 (functional) = 13.3 mg kg-1 Effective dose of perorally administered compound against B16 melanoma BL6 cells implanted into mice ChEMBL. 15149677

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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