Detailed information for compound 402397

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1329.79 | Formula: C40H28Cl2N12O12Pt2++++++++
  • H donors: 0 H acceptors: 12 LogP: 3.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 3
  • SMILES: Clc1cc2c3cccc[n+]3[Pt+2]3([n+]2c(c1)c1cccc[n+]31)[n+]1ccc(cc1)c1cc[n+](cc1)[Pt+2]12[n+]3ccccc3c3[n+]2c(c2[n+]1cccc2)cc(c3)Cl.[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-]
  • InChi: 1S/2C15H10ClN3.C10H8N2.4NO3.2Pt/c2*16-11-9-14(12-5-1-3-7-17-12)19-15(10-11)13-6-2-4-8-18-13;1-5-11-6-2-9(1)10-3-7-12-8-4-10;4*2-1(3)4;;/h2*1-10H;1-8H;;;;;;/q;;;4*-1;2*+6
  • InChiKey: SCVAUPXLCYXCIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0034 0.0034
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0037
Brugia malayi 6-phosphofructokinase 0.0122 0.0093 0.107
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0005 0.0005
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0037
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0196 0.0158 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0081 0.0879
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0044
Echinococcus granulosus geminin 0.0189 0.0151 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0965 0.0831 0.957
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0256 0.021 0.06
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0005 0.0206
Trichomonas vaginalis set domain proteins, putative 0.0264 0.0217 0.2459
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0519 0.044 0.5074
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Schistosoma mansoni histamine h1 receptor 0.0055 0.0034 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0015 0.0117
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0296 0.0245 0.2986
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0116
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0034 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0036 0.0363
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0005 0.0043
Brugia malayi sulfakinin receptor protein 0.0055 0.0034 0.0391
Echinococcus multilocularis casein kinase ii subunit alpha 0.0154 0.0121 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0034 0.0264
Giardia lamblia Hypothetical protein 0.0196 0.0158 0.1753
Loa Loa (eye worm) phosphatidylinositol kinase 0.0196 0.0158 0.1375
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0005 0.0055
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Loa Loa (eye worm) hypothetical protein 0.0196 0.0158 0.1375
Onchocerca volvulus 0.0055 0.0034 0.1122
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0034 0.0296
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0213 0.0172 0.0491
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.1445 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0093 0.1021
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0519 0.044 0.3837
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0122 0.0093 0.5749
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0036 0.0017 0.0135
Brugia malayi PXA domain containing protein 0.0023 0.0006 0.0071
Echinococcus granulosus allatostatin A receptor 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0046 0.0477
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0965 0.0831 0.957
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0034 0.1122
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0955 0.0821 0.2359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Loa Loa (eye worm) phosphatidylinositol 3 0.1327 0.1147 1
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0022 0.0738
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0453 0.0382 0.4371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0034 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0036 0.0363
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0034 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0196 0.0158 0.1818
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0039 0.0392
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0361 0.0302 0.2631
Onchocerca volvulus 0.0055 0.0034 0.1122
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Brugia malayi Dopamine receptor protein 2 0.0055 0.0034 0.0391
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0108 0.008 0.0626
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0268 0.3055
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0196 0.0158 0.1851
Loa Loa (eye worm) phosphatidylinositol 3 0.0196 0.0158 0.1375
Mycobacterium ulcerans 6-phosphofructokinase 0.0122 0.0093 1
Schistosoma mansoni biogenic amine receptor 0.0055 0.0034 0.0264
Schistosoma mansoni myosin xvIII 0.0055 0.0034 0.0264
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0034 0.0034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0034 0.0391
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0022
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1484 0.1285 0.1284
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0034 0.0296
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0296 0.0245 0.2986
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.003 0.0012 0.0143
Echinococcus granulosus expressed protein 0.042 0.0353 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9099
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0034 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0002
Schistosoma mansoni opsin-like receptor 0.0055 0.0034 0.0264
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0006 0.0054
Schistosoma mansoni neuropeptide receptor 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0015 0.0122
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Entamoeba histolytica hypothetical protein 0.0196 0.0158 0.1773
Echinococcus multilocularis lamin 0.003 0.0012 0.0012
Entamoeba histolytica protein kinase rad3, putative 0.0519 0.044 0.5047
Schistosoma mansoni serine/threonine protein kinase 0.0361 0.0302 0.235
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0965 0.0831 0.2386
Onchocerca volvulus 0.0057 0.0036 0.1193
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0611 0.052 0.6195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9099
Onchocerca volvulus 0.0055 0.0034 0.1122
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0093 0.1021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0158 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0945 0.0812 0.936
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0216 0.0174 0.0174
Brugia malayi phosphofructokinase 0.0122 0.0093 0.107
Toxoplasma gondii target of rapamycin (TOR), putative 0.0939 0.0808 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0015 0.0132
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0034 0.0034
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0069 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0005 0.0037
Onchocerca volvulus 0.0055 0.0034 0.1122
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0536 0.0455 0.1304
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0017 0.0017
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0017 0.0017
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0965 0.0831 0.6465
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0034 0.0034
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0196 0.0158 0.6446
Onchocerca volvulus 0.0108 0.008 0.2662
Brugia malayi hypothetical protein 0.0022 0.0005 0.0055
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0034 0.0034
Echinococcus granulosus hypothetical protein 0.0055 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Plasmodium falciparum casein kinase 2, alpha subunit 0.0154 0.0121 0.484
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0196 0.0158 0.6384
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.0772 0.8889
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.003 0.0012 0.0012
Onchocerca volvulus 0.0055 0.0034 0.1122
Trypanosoma brucei protein kinase, putative 0.0057 0.0036 0.0376
Schistosoma mansoni biogenic amine receptor 0.0055 0.0034 0.0264
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0158 0.1773
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0057
Loa Loa (eye worm) RecQ helicase 0.0024 0.0007 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0116
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0041 0.0022 0.0056
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0034 0.0264
Brugia malayi bHLH-PAS transcription factor 0.004 0.0021 0.0246
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0245 0.07
Loa Loa (eye worm) intermediate filament protein 0.003 0.0012 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0034 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0034 0.0264
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0519 0.044 0.044
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Plasmodium vivax hypothetical protein, conserved 0.0196 0.0158 0.6446
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.003 0.0012 0.0012
Brugia malayi hypothetical protein 0.0529 0.0449 0.5177
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1008 0.0868 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0034 0.0264
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0000070625 0.0000000036656
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0116
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0965 0.0831 1
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0034 0.0296
Echinococcus granulosus high voltage activated calcium channel beta 0.0098 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi Protein kinase domain containing protein 0.015 0.0118 0.1354
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0005
Onchocerca volvulus 0.0055 0.0034 0.1122
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Brugia malayi RE15519p 0.0055 0.0034 0.0391
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Echinococcus granulosus g protein coupled receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0561 0.0476 0.5466
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.0046 0.0496
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0296 0.0245 0.1905
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0054 0.0033 0.0286
Loa Loa (eye worm) calcium channel 0.0036 0.0017 0.0152
Brugia malayi Dopamine receptor protein 1 0.0055 0.0034 0.0391
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Onchocerca volvulus 0.0055 0.0034 0.1122
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0022 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0034
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0098 0.0071 0.0554
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0021 0.0021
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Onchocerca volvulus 0.0196 0.0158 0.5225
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0519 0.044 0.044
Leishmania major phosphatidylinositol kinase, putative 0.0196 0.0158 0.0428
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0036 0.0017 0.0135
Loa Loa (eye worm) hypothetical protein 0.0382 0.032 0.2792
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0196 0.0158 0.6384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0945 0.0812 0.936
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0296 0.0245 0.2781
Echinococcus multilocularis high voltage activated calcium channel beta 0.0098 0.0071 0.0071
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0046 0.0477
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0015 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.0945 0.0812 0.2334
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0069 0.0046 0.0357
Echinococcus granulosus lamin 0.003 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0536 0.0455 0.524
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0196 0.0158 0.1773
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0022 0.0738
Onchocerca volvulus 0.0264 0.0217 0.7189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.01 0.0074 0.0074
Echinococcus granulosus intermediate filament protein 0.003 0.0012 0.0012
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0093 0.0262
Loa Loa (eye worm) phosphatidylinositol 3 0.0196 0.0158 0.1375
Leishmania major phosphatidylinositol kinase related protein, putative 0.0213 0.0172 0.0468
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0965 0.0831 1
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0005 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0596 0.0507 0.6085
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0531 0.0451 0.517
Leishmania major cytochrome p450-like protein 0.0022 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0924 0.0794 0.9151
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0005 0.0005
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0008 0.0071
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0744 0.0637 0.5551
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1484 0.1285 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0089
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0034 0.0264
Schistosoma mansoni hypothetical protein 0.0055 0.0034 0.0264
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0767 0.0657 0.7563
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0069 0.0046 0.0046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0015 0.0015
Loa Loa (eye worm) gastrulation defective protein 1 0.0147 0.0114 0.0995
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0005
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0154 0.0121 0.4929
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0296 0.0245 0.2133
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi 6-phosphofructokinase 0.0122 0.0093 0.107
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0046 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.0772 0.8889
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0196 0.0158 0.1773
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0196 0.0158 0.0449
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0047 0.0027 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0453 0.0382 0.4566
Leishmania major phosphatidylinositol 4-kinase, putative 0.0196 0.0158 0.0428
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0296 0.0245 1
Brugia malayi Csnk2b protein 0.0041 0.0022 0.0253
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0196 0.0158 0.0449
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0036 0.0036
Brugia malayi putative neuropeptide receptor 0.0055 0.0034 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9098
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0116
Echinococcus granulosus casein kinase ii subunit alpha 0.0154 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0851 0.073 0.841
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Schistosoma mansoni adenoreceptor 0.0055 0.0034 0.0264
Onchocerca volvulus 0.0113 0.0085 0.2804
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0046 0.0127
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Echinococcus granulosus cyclin dependent kinase 19 0.015 0.0118 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Trypanosoma cruzi casein kinase II, putative 0.0154 0.0121 0.0342
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0196 0.0158 0.1773
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.003 0.0012 0.0096
Schistosoma mansoni fkbp-rapamycin associated protein 0.0519 0.044 0.3427
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Leishmania major hypothetical protein, unknown function 0.0196 0.0158 0.0428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.0772 0.8889
Echinococcus granulosus serine protein kinase ATM 0.0536 0.0455 0.0455
Echinococcus granulosus g protein coupled receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0965 0.0831 0.957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0945 0.0812 0.936
Toxoplasma gondii FATC domain-containing protein 0.0536 0.0455 0.5601
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0002 0.0018
Leishmania major phosphatidylinositol 3-kinase, putative 0.0898 0.0772 0.2113
Schistosoma mansoni amine GPCR 0.0055 0.0034 0.0264
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0005
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0339 0.0283 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0046 0.0477
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0965 0.0831 0.2274
Brugia malayi serine/threonine-protein kinase plk-2 0.0216 0.0174 0.2011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0014 0.0014
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0034 0.0391
Loa Loa (eye worm) phosphatidylinositol 3 0.0965 0.0831 0.7238
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0196 0.0158 0.1228
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Onchocerca volvulus 0.0055 0.0034 0.1122
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0361 0.0302 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0034 0.0034
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0036 0.1474
Brugia malayi FAT domain containing protein 0.0379 0.0317 0.3658
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0519 0.044 0.1263
Brugia malayi Melatonin receptor type 1A 0.0055 0.0034 0.0391
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0296 0.0245 0.2781
Echinococcus granulosus 6 phosphofructokinase 0.0122 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0245 0.07
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0037
Schistosoma mansoni amine GPCR 0.0055 0.0034 0.0264
Echinococcus granulosus single minded 2 0.004 0.0021 0.0021
Brugia malayi intracellular kinase 0.0057 0.0036 0.0416
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0093 0.0722
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0017 0.0017
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0036 0.1324
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.01 0.0074 0.0572
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1008 0.0868 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0034 0.0034
Onchocerca volvulus 0.003 0.0012 0.0403
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0296 0.0245 0.0245
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0015 0.0116
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0196 0.0158 0.0158
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0034 0.0034
Entamoeba histolytica serine/threonine protein kinase, putative 0.0216 0.0174 0.1967
Echinococcus granulosus neuropeptide receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.015 0.0118 0.1024
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0036 0.0261
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0116
Entamoeba histolytica hypothetical protein 0.004 0.0021 0.0192
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0034 0.0034
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0034 0.0034
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0196 0.0158 0.0158
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0093 0.0809
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0912 0.0784 0.0784
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0034 0.0034
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1008 0.0868 0.2493
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0000070588 0.0001
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0379 0.0317 0.0317
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0005 0.0005
Brugia malayi Death domain containing protein 0.0016 0.0000070625 0.0001
Entamoeba histolytica hypothetical protein 0.0536 0.0455 0.5214
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus granulosus protein kinase shaggy 0.0057 0.0036 0.0036
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Schistosoma mansoni survival motor neuron protein 0.0108 0.008 0.0626
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0106
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0196 0.0158 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Echinococcus multilocularis sex peptide receptor 0.0055 0.0034 0.0034
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0015 0.0122
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0034 0.0264
Brugia malayi SH2 domain containing protein 0.0382 0.032 0.3692
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0022 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0043
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0015 0.0605
Echinococcus multilocularis serine protein kinase ATM 0.0536 0.0455 0.0455
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0851 0.073 0.841
Onchocerca volvulus 0.0055 0.0034 0.1122
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0034 0.0034
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0036 0.0094
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0055
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0093 0.1021
Loa Loa (eye worm) phosphatidylinositol 3 0.0196 0.0158 0.1375
Onchocerca volvulus 0.003 0.0012 0.0403
Onchocerca volvulus 0.0113 0.0085 0.2804
Schistosoma mansoni hypothetical protein 0.0055 0.0034 0.0264
Onchocerca volvulus 0.0055 0.0034 0.1122
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0955 0.0821 0.6393
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Onchocerca volvulus 0.0046 0.0026 0.0864
Echinococcus multilocularis tumor protein p63 0.038 0.0318 0.0318
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0022 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0003
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0000070625 0.000000028537
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0034 0.0034
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0965 0.0831 0.9572
Echinococcus multilocularis somatostatin receptor 0.0055 0.0034 0.0034
Brugia malayi G protein-coupled receptor 0.0055 0.0034 0.0391
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0189 0.0151 0.1177
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0196 0.0158 0.1818
Trypanosoma cruzi polo-like protein kinase, putative 0.0216 0.0174 0.0498
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0026 0.0203
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0005
Echinococcus multilocularis 6 phosphofructokinase 0.0122 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.0046 0.0496
Mycobacterium leprae conserved hypothetical protein 0.0196 0.0158 1
Echinococcus multilocularis expressed conserved protein 0.0092 0.0066 0.0066
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0041 0.0022 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0015 0.0124
Onchocerca volvulus 0.0055 0.0034 0.1122
Loa Loa (eye worm) hypothetical protein 0.0033 0.0015 0.0131
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0037
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1008 0.0868 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0196 0.0158 0.1228
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0034 0.0034
Entamoeba histolytica protein kinase domain containing protein 0.0154 0.0121 0.1343
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0034 0.0264
Trypanosoma brucei polo-like protein kinase 0.0216 0.0174 0.2053
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0034 0.0264
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0965 0.0831 0.2274
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0361 0.0302 0.348
Trichomonas vaginalis conserved hypothetical protein 0.0575 0.0489 0.5615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.053 0.6086
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0361 0.0302 0.0302
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0196 0.0158 0.1902
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0022 0.0199
Loa Loa (eye worm) hypothetical protein 0.0183 0.0146 0.1276
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0047 0.0027 0.0255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0021 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0034 0.0296
Leishmania major phosphatidylinositol 3-related kinase, putative 0.091 0.0782 0.2141
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0034 0.0034
Brugia malayi PAS domain containing protein 0.0055 0.0034 0.0389
Echinococcus granulosus sex peptide receptor 0.0055 0.0034 0.0034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0965 0.0831 0.2386
Schistosoma mansoni opsin-like receptor 0.0055 0.0034 0.0264
Echinococcus granulosus serotonin receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0361 0.0302 0.0302
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0477 0.0403 0.4643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.0134 0.1168
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0035 0.0269
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0021 0.0021
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0022 0.0199
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0453 0.0382 0.4371
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0007 0.0023
Echinococcus granulosus neuropeptide receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0047 0.0027 0.0255
Brugia malayi G-protein coupled receptor 0.0055 0.0034 0.0391
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0036 0.0363
Echinococcus multilocularis expressed protein 0.042 0.0353 0.0353
Onchocerca volvulus 0.0196 0.0158 0.5225
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0034 0.0296
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0924 0.0794 0.9151
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0034 0.0264
Toxoplasma gondii CMGC kinase, CK2 family 0.0154 0.0121 0.144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0008 0.0093
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0015 0.5
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9099
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0196 0.0158 0.1902
Loa Loa (eye worm) hypothetical protein 0.0056 0.0035 0.0301
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0000070625 0.0000000036656
Schistosoma mansoni lamin 0.003 0.0012 0.0095
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.3988 0.3475 1
Entamoeba histolytica hypothetical protein 0.004 0.0021 0.0192
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni voltage-gated cation channel 0.0036 0.0017 0.0135
Echinococcus granulosus g protein coupled receptor 0.0055 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Plasmodium vivax SET domain protein, putative 0.0033 0.0015 0.0615
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0008 0.0063
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9098
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0245 0.2905
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0955 0.0821 0.0821
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0055
Schistosoma mansoni hypothetical protein 0.0092 0.0066 0.0515
Loa Loa (eye worm) hypothetical protein 0.0379 0.0317 0.2766
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0296 0.0245 0.0245
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0453 0.0382 0.4371
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0015 0.0122
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0296 0.0245 1
Schistosoma mansoni opsin-like receptor 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0811 0.0696 0.8008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0945 0.0812 0.936
Brugia malayi hypoxia-induced factor 1 0.0169 0.0134 0.1545
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0015 0.0441
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0744 0.0637 0.0637
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.0174 0.1358
Leishmania major casein kinase II, putative 0.0154 0.0121 0.0326
Brugia malayi neuropeptide F receptor 0.0055 0.0034 0.0391
Echinococcus granulosus orexin receptor type 2 0.0055 0.0034 0.0034
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0005 0.0007
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0196 0.0158 0.0158
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0034 0.0264
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0122 0.0093 0.5749
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0015 0.0116
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0034 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0176 0.1982
Schistosoma mansoni intermediate filament proteins 0.003 0.0012 0.0095
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0965 0.0831 0.083
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0093 0.0722
Onchocerca volvulus 0.004 0.0021 0.0705
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0296 0.0245 0.2821
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0504 0.0427 0.4889
Echinococcus multilocularis 0.0196 0.0158 0.0158
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0453 0.0382 0.4402
Loa Loa (eye worm) phosphatidylinositol 3 0.0196 0.0158 0.1375
Onchocerca volvulus 0.0055 0.0034 0.1122
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0767 0.0657 0.7563
Brugia malayi GnHR receptor homolog 0.0055 0.0034 0.0391
Echinococcus granulosus Ankyrin repeat domain containing protein 0.01 0.0074 0.0074
Brugia malayi M-phase phosphoprotein, mpp8 0.0113 0.0085 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0317 0.3623
Schistosoma mansoni hypothetical protein 0.004 0.0021 0.0165
Loa Loa (eye worm) hypothetical protein 0.0575 0.0489 0.4264
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0296 0.0245 0.0245
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0021 0.0165
Loa Loa (eye worm) Csnk2b protein 0.0041 0.0022 0.0191
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0034 0.0296
Schistosoma mansoni amine GPCR 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0034 0.0034
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0034 0.0034
Brugia malayi AKH receptor 0.0055 0.0034 0.0391
Entamoeba histolytica protein kinase, putative 0.0057 0.0036 0.0363
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0007 0.0077
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0561 0.0476 0.5466
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.008 0.0927
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0034 0.0034
Schistosoma mansoni neuropeptide receptor 0.0055 0.0034 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0039 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.044 0.5047
Brugia malayi Protein kinase domain containing protein 0.002 0.0003 0.0039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0034 0.0034
Plasmodium vivax hypothetical protein 0.0196 0.0158 0.6446
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Onchocerca volvulus 0.0055 0.0034 0.1122
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0034 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0093 0.1021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0201 0.0162 0.1864
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0122 0.0093 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0216 0.0174 0.0498
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Giardia lamblia Phosphatidylinositol 4-kinase 0.0196 0.0158 0.1753
Schistosoma mansoni hypothetical protein 0.0196 0.0158 0.1228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0034 0.0264
Brugia malayi ORL1-like opioid receptor 0.0055 0.0034 0.0391
Loa Loa (eye worm) phosphatidylinositol 3 0.091 0.0782 0.6818
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0015 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0036 0.0017 0.0017
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0041 0.0022 0.0206
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0036 0.0363
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0008 0.0063
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0022 0.0058
Entamoeba histolytica hypothetical protein 0.0196 0.0158 0.1773
Loa Loa (eye worm) phosphatidylinositol 3 0.0256 0.021 0.1831
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0955 0.0821 0.9465
Echinococcus multilocularis geminin 0.0189 0.0151 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0022 0.0897
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0034 0.0034
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0034 0.0391
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0965 0.0831 0.083
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0296 0.0245 0.2781
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0361 0.0302 0.2631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0268 0.3055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0034 0.0034
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Echinococcus multilocularis serotonin receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0174 0.1967
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0955 0.0821 0.2359
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0955 0.0821 0.0821
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0196 0.0158 0.1818
Echinococcus granulosus bloom syndrome protein 0.0024 0.0007 0.0007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0529 0.0449 0.3915
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0238 0.0194 0.2288
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0898 0.0772 0.9288
Entamoeba histolytica casein kinase, putative 0.0154 0.0121 0.1343
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0093 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.0772 0.8889
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0015 0.0605
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0089
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0566 0.0481 0.5519
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1008 0.0868 1
Mycobacterium ulcerans putative regulatory protein 0.004 0.0021 0.1861
Onchocerca volvulus 0.0055 0.0034 0.1122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0055 0.0034 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0945 0.0812 0.936
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0201 0.0162 0.141
Brugia malayi hypothetical protein 0.0022 0.0005 0.0055
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0536 0.0455 0.5219
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0034 0.0391
Echinococcus multilocularis cyclin dependent kinase 19 0.015 0.0118 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Echinococcus multilocularis survival motor neuron protein 1 0.0529 0.0449 0.0449
Brugia malayi Pre-SET motif family protein 0.0033 0.0015 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0561 0.0476 0.5466
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0005 0.0037
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0313 0.026 0.2268
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0022 0.0725
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0046 0.0127
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0453 0.0382 0.1095
Echinococcus granulosus survival motor neuron protein 1 0.0529 0.0449 0.0449
Schistosoma mansoni hypothetical protein 0.0189 0.0151 0.1177
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0034 0.0034
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0216 0.0174 0.1521
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0196 0.0158 0.6446
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0034 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0965 0.0831 0.957
Echinococcus granulosus lamin dm0 0.003 0.0012 0.0012
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0945 0.0812 0.9782
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0034 0.0296
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.0189 0.1646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0113 0.0085 0.0738
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0034 0.1122
Onchocerca volvulus 0.0055 0.0034 0.1122
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0196 0.0158 0.0449
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0015 0.0441
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0034 0.0391
Echinococcus granulosus somatostatin receptor 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0455 0.5214
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0039 0.0392
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0055 0.0034 0.0264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Plasmodium falciparum GAF domain-related protein, putative 0.0022 0.0005 0.0035
Brugia malayi hypothetical protein 0.0183 0.0146 0.1688
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Brugia malayi Cytochrome P450 family protein 0.0033 0.0015 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0015 0.0117
Schistosoma mansoni biogenic amine receptor 0.0055 0.0034 0.0264
Entamoeba histolytica hypothetical protein 0.0196 0.0158 0.1773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0747 0.0639 0.7367
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0005
Echinococcus multilocularis casein kinase ii subunit beta 0.0041 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0939 0.0808 0.9307
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0152
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0034 0.0034
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0007 0.0007
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Schistosoma mansoni amine GPCR 0.0055 0.0034 0.0264
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0034 0.0391
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0037
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0036 0.0261
Entamoeba histolytica hypothetical protein 0.004 0.0021 0.0192
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Brugia malayi intermediate filament protein 0.003 0.0012 0.0141
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0034 0.0034
Echinococcus granulosus tumor protein p63 0.038 0.0318 0.0318
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0007 0.0023
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0012 0.0143
Schistosoma mansoni kinase 0.0111 0.0083 0.0646
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0005
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Brugia malayi Casein kinase II, alpha chain 0.0154 0.0121 0.139
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.091 0.0782 0.9416
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0034 0.0391
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0034 0.0264
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0945 0.0812 0.2224
Schistosoma mansoni single-minded 0.0055 0.0034 0.0262
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0036 0.0314
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0196 0.0158 0.1228
Trypanosoma brucei Casein kinase II 0.0154 0.0121 0.1401
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0536 0.0455 0.3539
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0034 0.0034
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0034 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0034 0.0034
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0005 0.001
Onchocerca volvulus 0.0055 0.0034 0.1122
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0008 0.0071
Entamoeba histolytica hypothetical protein 0.004 0.0021 0.0192
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0034 0.0034
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0036 0.0099
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0005 0.0055
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0093 0.1064
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0058 0.0058
Brugia malayi Serotonin receptor 0.0572 0.0486 0.5607
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0034 0.0264
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0034 0.0391
Schistosoma mansoni casein kinase II beta subunit 0.0041 0.0022 0.017
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0071 0.0071
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0036 0.0386
Schistosoma mansoni neuropeptide receptor 0.0055 0.0034 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0034 0.0264
Brugia malayi hypothetical protein 0.004 0.0021 0.0246
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0216 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0315 0.0261 0.2277
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1484 0.1285 0.1284
Onchocerca volvulus 0.0055 0.0034 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9099
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0379 0.0317 0.0317
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0036 0.0017 0.0201
Onchocerca volvulus 0.0056 0.0035 0.1143
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0022 0.0897
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0034 0.0296
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0216 0.0174 0.0474
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0744 0.0637 0.0637
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0022 0.0199
Giardia lamblia Kinase, PLK 0.0216 0.0174 0.1958
Schistosoma mansoni hypothetical protein 0.0055 0.0034 0.0264
Brugia malayi Pre-SET motif family protein 0.0232 0.0189 0.2177
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.0782 0.9011
Brugia malayi neuropeptide F receptor 0.0055 0.0034 0.0391
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0536 0.0455 0.5447
Schistosoma mansoni protein kinase 0.0154 0.0121 0.0939
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0017 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0005 0.001
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0531 0.0451 0.517
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0196 0.0158 0.1851
Brugia malayi Dopamine receptor 0.0055 0.0034 0.0391
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0036 0.0017 0.0017
Toxoplasma gondii hypothetical protein 0.006 0.0039 0.0418
Echinococcus multilocularis lamin dm0 0.003 0.0012 0.0012
Schistosoma mansoni lamin 0.003 0.0012 0.0095
Brugia malayi hypothetical protein 0.0113 0.0085 0.0977
Echinococcus granulosus fmrfamide receptor 0.0055 0.0034 0.0034
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Schistosoma mansoni neuropeptide receptor 0.0055 0.0034 0.0264
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0353 0.0295 0.3434
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0154 0.0121 0.1051
Echinococcus multilocularis serotonin receptor 0.0055 0.0034 0.0034
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0196 0.0158 0.1902
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0118 0.0914
Giardia lamblia Casein kinase II beta chain 0.0041 0.0022 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0081 0.0879
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0036 0.028
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0196 0.0158 0.6446
Loa Loa (eye worm) hypothetical protein 0.0113 0.0085 0.0739
Echinococcus multilocularis Zinc finger, PHD finger 0.0296 0.0245 0.0245
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0034 0.0034
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0093 0.1021
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0012 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0093 0.1021
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0034 0.0034
Echinococcus multilocularis musashi 0.003 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0919 0.079 0.9098
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0034 0.0296
Brugia malayi Protein kinase domain containing protein 0.0361 0.0302 0.348
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0034 0.0264
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0296 0.0245 0.1905
Leishmania major hypothetical protein, conserved 0.4184 0.3647 1
Giardia lamblia Kinase, CMGC CK2 0.0154 0.0121 0.1297
Loa Loa (eye worm) hypothetical protein 0.0339 0.0283 0.2465
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0034 0.0034
Plasmodium vivax unspecified product 0.0154 0.0121 0.4929
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0058 0.0036 0.0283
Brugia malayi larval opioid receptor 0.0055 0.0034 0.0391
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0034 0.0264
Brugia malayi hypothetical protein 0.0055 0.0034 0.0391
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0296 0.0245 0.2781
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0965 0.0831 0.957
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0034 0.0264
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0196 0.0158 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0036 0.0017 0.0017
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0296 0.0245 0.0667
Brugia malayi G-protein coupled receptor 0.0055 0.0034 0.0391
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0046 0.0477
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1008 0.0868 0.2493
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0379 0.0317 0.2471
Leishmania major phosphatidylinositol 3-kinase, putative 0.0296 0.0245 0.0667
Loa Loa (eye worm) phosphofructokinase 0.0122 0.0093 0.0809
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0575 0.0489 0.6031
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0034 0.0034
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0022 0.0199
Leishmania major ATP-dependent phosphofructokinase 0.0122 0.0093 0.025
Onchocerca volvulus Serine\/threonine kinase homolog 0.0216 0.0174 0.5778
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0046 0.0477
Brugia malayi Uncoordinated protein 44 0.0016 0.0000070625 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0116
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0036 0.0314
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Brugia malayi PXA domain containing protein 0.0023 0.0006 0.0071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0034 0.0034
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.01 0.0074 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.0499 0.5728
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0034 0.0034
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0196 0.0158 0.0158
Giardia lamblia GTOR 0.0965 0.0831 1
Brugia malayi Serotonin receptor 0.0055 0.0034 0.0391
Loa Loa (eye worm) hypothetical protein 0.0055 0.0034 0.0296
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0012 0.0106
Echinococcus granulosus casein kinase ii subunit beta 0.0041 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0008 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0034 0.0034
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1008 0.0868 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0034 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0093 0.1021
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0005 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0121 0.1343
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0296 0.0245 0.2781
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0005 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0313 0.026 0.2999
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0453 0.0382 0.4371
Toxoplasma gondii ck2 beta subunit 0.0041 0.0022 0.0211
Echinococcus granulosus expressed conserved protein 0.0092 0.0066 0.0066
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0506 0.0429 0.3338

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.59 uM In vitro inhibition of human ovarian cell line (CH1) ChEMBL. 10447962
IC50 (functional) = 0.69 uM In vitro inhibition of human ovarian cell line, resistant to doxorubicin (CH1doxR). ChEMBL. 10447962
IC50 (functional) = 0.87 uM In vitro inhibition of human ovarian cell line, resistant to cisplatin (CH1cisR). ChEMBL. 10447962
IC50 (functional) = 1.3 uM In vitro inhibition of human ovarian cell line SKOV-3. ChEMBL. 10447962
IC50 (functional) = 18.5 uM In vitro inhibition of human ovarian cell line, resistant to cisplatin (A2780cisR). ChEMBL. 10447962
IC50 (functional) > 25 uM In vitro inhibition of human ovarian cell line A2780 ChEMBL. 10447962
Resistance factor (functional) = 1.1 Resistance factor, (IC50 of CH1 doxR / IC50 of CH1) ChEMBL. 10447962
Resistance factor (functional) = 1.5 Resistance factor, (IC50 of CH1 cisR / IC50 of CH1) ChEMBL. 10447962

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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