Detailed information for compound 402541

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2577.29 | Formula: C82H128N3Na11O57S8
  • H donors: 4 H acceptors: 37 LogP: 6.99 Rotable bonds: 80
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCCCCCC(=O)OC/C(=C\C(=O)[O-])/OC1OC(COS(=O)(=O)[O-])C(C(C1NS(=O)(=O)[O-])OC(=O)CCCCCCC)OC1OC(C(=O)[O-])C(C(C1OS(=O)(=O)[O-])OC(=O)CCCCCCC)OC1OC(COS(=O)(=O)[O-])C(C(C1NS(=O)(=O)[O-])OC(=O)CCCCCCC)OC1OC(C(=O)[O-])C(C(C1OS(=O)(=O)[O-])OC(=O)CCCCCCC)OC1OC(CS(=O)(=O)[O-])C(C(C1NS(=O)(=O)[O-])OC(=O)CCCCCCC)O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C82H139N3O57S8.11Na/c1-7-13-19-25-31-37-53(88)123-44-48(43-52(86)87)126-78-60(84-145(105,106)107)66(131-55(90)39-33-27-21-15-9-3)63(49(127-78)45-124-147(111,112)113)135-81-75(142-150(120,121)122)71(134-58(93)42-36-30-24-18-12-6)69(73(140-81)77(97)98)138-80-61(85-146(108,109)110)67(132-56(91)40-34-28-22-16-10-4)64(50(128-80)46-125-148(114,115)116)136-82-74(141-149(117,118)119)70(133-57(92)41-35-29-23-17-11-5)68(72(139-82)76(95)96)137-79-59(83-144(102,103)104)65(62(94)51(129-79)47-143(99,100)101)130-54(89)38-32-26-20-14-8-2;;;;;;;;;;;/h43,49-51,59-75,78-85,94H,7-42,44-47H2,1-6H3,(H,86,87)(H,95,96)(H,97,98)(H,99,100,101)(H,102,103,104)(H,105,106,107)(H,108,109,110)(H,111,112,113)(H,114,115,116)(H,117,118,119)(H,120,121,122);;;;;;;;;;;/q;11*+1/p-11/b48-43+;;;;;;;;;;;
  • InChiKey: KDYCBUATUZYOLD-VHXXFDBQSA-C  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol kinase 0.0132 0.0172 0.0981
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.035 0.0492 0.1413
Loa Loa (eye worm) hypothetical protein 0.0334 0.0469 0.2675
Loa Loa (eye worm) hypothetical protein 0.0653 0.0937 0.5347
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0024 0.0123
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0058 0.0057
Schistosoma mansoni regulator of G protein signaling 0.002 0.0008 0.0038
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.0000000058483
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0028 0.0028
Giardia lamblia Casein kinase II beta chain 0.0039 0.0035 0.0129
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0065 0.0074 0.0371
Schistosoma mansoni serine/threonine protein kinase 0.0343 0.0482 0.2444
Echinococcus granulosus lamin 0.0029 0.002 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0132 0.0172 0.1969
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0039 0.0035 0.0404
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1358 0.197 0.197
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0029 0.002 0.002
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0227 0.0311 0.0311
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0129 0.0933
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0237 0.0326 0.0325
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0188 0.0951
Brugia malayi intermediate filament protein 0.0029 0.002 0.0149
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0172 0.023 0.2456
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0148 0.0148
Echinococcus granulosus axis inhibition protein axin 0.002 0.0008 0.0008
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0008 0.0058
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Toxoplasma gondii hypothetical protein 0.0057 0.0062 0.0707
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0346 0.261
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Trypanosoma brucei polo-like protein kinase 0.0205 0.0279 0.2997
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0028 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0058 0.0385
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0008 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0132 0.0172 0.0981
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0058 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.1209 0.1752 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.0486 0.3683
Schistosoma mansoni casein kinase II beta subunit 0.0039 0.0035 0.0177
Brugia malayi hypothetical protein 0.002 0.0008 0.0058
Loa Loa (eye worm) calcium channel 0.0034 0.0028 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0042 0.0211
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0772 0.1111 0.8501
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.002 0.0094
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0635 0.091 0.6958
Echinococcus granulosus casein kinase ii subunit beta 0.0039 0.0035 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0029 0.002 0.002
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0148 0.0845
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6829 1 1
Schistosoma mansoni hypothetical protein 0.018 0.0242 0.1224
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.035 0.0492 0.5359
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.0074 0.0724
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0148 0.0845
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0058 0.0385
Leishmania major phosphatidylinositol 4-kinase, putative 0.0132 0.0172 0.0463
Echinococcus multilocularis lamin dm0 0.0029 0.002 0.0019
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0008 0.0043
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0132 0.0172 0.0172
Entamoeba histolytica protein kinase domain containing protein 0.0146 0.0193 0.1425
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0227 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0363 0.0511 0.2917
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.002 0.0094
Brugia malayi Cytochrome P450 family protein 0.0021 0.0008 0.0061
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0011 0.0082
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0653 0.0937 0.0936
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0218 0.0297 0.0851
Brugia malayi Pre-SET motif family protein 0.0221 0.0302 0.231
Onchocerca volvulus 0.0103 0.0129 0.2662
Loa Loa (eye worm) hypothetical protein 0.0132 0.0172 0.0981
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0024 0.0123
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0148 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0201 0.1488
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0093 0.0114 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0029 0.002 0.0111
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0013 0.0013
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0227 0.0311 0.2337
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0205 0.0279 0.0754
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0425 0.0601 0.4574
Schistosoma mansoni regulator of G protein signaling 0.002 0.0008 0.0038
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0074 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Echinococcus multilocularis casein kinase ii subunit beta 0.0039 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0024 0.0121
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0028 0.0141
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Echinococcus granulosus intermediate filament protein 0.0029 0.002 0.0019
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0013 0.0074
Echinococcus multilocularis high voltage activated calcium channel beta 0.0093 0.0114 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.0279 0.1412
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0024 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0132 0.0172 0.0489
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0028 0.0028
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0024 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.091 0.6958
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0904 0.1305 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.037 0.052 0.3949
Giardia lamblia Kinase, CMGC CK2 0.0146 0.0193 0.1904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.0526 0.3997
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0035 0.0931
Echinococcus granulosus bloom syndrome protein 0.0023 0.0011 0.0011
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0227 0.0311 0.2337
Brugia malayi hypothetical protein 0.002 0.0008 0.0058
Echinococcus granulosus single minded 2 0.0038 0.0034 0.0034
Schistosoma mansoni regulator of G protein signaling 0.002 0.0008 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0846 0.6458
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0058 0.1671
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0129 0.0933
Schistosoma mansoni axis inhibition protein axin 0.002 0.0008 0.0038
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0034 0.0172
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0132 0.0172 0.0872
Echinococcus granulosus casein kinase ii subunit alpha 0.0146 0.0193 0.0192
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0132 0.0172 0.0489
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0132 0.0172 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.053 0.4059
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0008 0.0007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0635 0.091 0.091
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Onchocerca volvulus 0.0044 0.0042 0.0865
Trypanosoma brucei Casein kinase II 0.0146 0.0193 0.2045
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.0279 0.0797
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0625 0.0896 0.2581
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0148 0.1083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0625 0.0896 0.6862
Echinococcus granulosus survival motor neuron protein 1 0.0504 0.0717 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Toxoplasma gondii hypothetical protein 0.0021 0.0008 0.0095
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0148 0.1083
Brugia malayi SH2 domain containing protein 0.0363 0.0511 0.3916
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0227 0.0311 0.1774
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0148 0.1083
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0024 0.0123
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0227 0.0311 0.1577
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0755 0.1086 0.8312
Toxoplasma gondii CMGC kinase, CK2 family 0.0146 0.0193 0.2204
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0008 0.0008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.0355 0.2026
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0028 0.0028
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0058 0.0057
Entamoeba histolytica protein kinase rad3, putative 0.0334 0.0469 0.3553
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0024 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0244 0.0335 0.0961
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0656 0.094 0.7206
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0191 0.0258 0.1977
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0635 0.091 0.6958
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0376 0.053 0.4024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.091 0.6958
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0583 0.0834 0.9148
Echinococcus granulosus tumor protein p63 0.0361 0.0508 0.0508
Loa Loa (eye worm) phosphatidylinositol 3 0.0132 0.0172 0.0981
Brugia malayi Cytochrome P450 family protein 0.0032 0.0024 0.0185
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0376 0.053 0.4024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0846 0.6458
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0008 0.0008
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0034 0.0034
Plasmodium vivax hypothetical protein 0.0132 0.0172 0.5533
Plasmodium falciparum casein kinase 2, alpha subunit 0.0146 0.0193 0.6108
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0132 0.0172 0.1317
Leishmania major phosphatidylinositol kinase, putative 0.0132 0.0172 0.0463
Loa Loa (eye worm) phosphatidylinositol 3 0.0583 0.0834 0.4758
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0132 0.0172 0.5434
Onchocerca volvulus 0.0107 0.0135 0.2805
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0058 0.015
Trypanosoma cruzi casein kinase II, putative 0.0146 0.0193 0.0549
Echinococcus granulosus lamin dm0 0.0029 0.002 0.0019
Toxoplasma gondii target of rapamycin (TOR), putative 0.0611 0.0874 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0024 0.0123
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Brugia malayi phosphofructokinase 0.0116 0.0148 0.1135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0845 0.6457
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0028 0.0028
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0143 0.0188 0.107
Entamoeba histolytica hypothetical protein 0.0038 0.0034 0.0203
Mycobacterium leprae conserved hypothetical protein 0.0132 0.0172 1
Entamoeba histolytica hypothetical protein 0.0132 0.0172 0.1267
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.0492 0.373
Brugia malayi hypoxia-induced factor 1 0.0161 0.0214 0.1638
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0227 0.0311 0.2337
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0132 0.0172 0.0172
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0132 0.0172 0.1317
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0227 0.0311 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0882 0.6736
Leishmania major phosphatidylinositol 3-kinase, putative 0.0572 0.0817 0.2227
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0074 0.0506
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0008 0.0045
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1358 0.197 0.197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.0817 0.6236
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0008 0.0259
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0118 0.0595
Echinococcus granulosus cyclin dependent kinase 19 0.0143 0.0188 0.0187
Schistosoma mansoni hypothetical protein 0.018 0.0242 0.1224
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0148 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0867 0.125 0.125
Brugia malayi hypothetical protein 0.0504 0.0717 0.5492
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0376 0.053 0.1523
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0043 0.0271
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0132 0.0172 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.0302 0.1721
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0039 0.0035 0.0089
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0093 0.0114 0.0113
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Giardia lamblia GTOR 0.0635 0.091 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0398 0.0562 0.4276
Echinococcus multilocularis tumor protein p63 0.0361 0.0508 0.0508
Schistosoma mansoni protein kinase 0.0146 0.0193 0.0976
Brugia malayi Protein kinase domain containing protein 0.0343 0.0482 0.3691
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0024 0.0556
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0111
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.002 0.01
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0635 0.091 0.2484
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0227 0.0311 1
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0146 0.0193 0.1099
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0035 0.0931
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0024 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904 0.1305 0.3764
Echinococcus multilocularis 0.0132 0.0172 0.0172
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0035 0.0211
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0148 0.0148
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0035 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0024 0.0123
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0074 0.0204
Leishmania major casein kinase II, putative 0.0146 0.0193 0.0519
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Schistosoma mansoni hypothetical protein 0.0087 0.0106 0.0535
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0011 0.0011
Giardia lamblia Phosphatidylinositol 4-kinase 0.0132 0.0172 0.1673
Loa Loa (eye worm) phosphatidylinositol 3 0.0132 0.0172 0.0981
Brugia malayi serine/threonine-protein kinase plk-2 0.0205 0.0279 0.2133
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0043
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0024 0.076
Brugia malayi PAS domain containing protein 0.0052 0.0054 0.0413
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0635 0.091 0.2624
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0882 0.6736
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0343 0.0482 0.275
Brugia malayi M-phase phosphoprotein, mpp8 0.0107 0.0135 0.1036
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0013 0.0099
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0635 0.091 1
Echinococcus multilocularis musashi 0.0029 0.002 0.0019
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0625 0.0896 0.0895
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0058 0.0382
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0028 0.0213
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0148 0.8546
Brugia malayi Protein kinase domain containing protein 0.0143 0.0188 0.1437
Echinococcus granulosus high voltage activated calcium channel beta 0.0093 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0534 0.4053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.0834 0.6366
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0024 0.0123
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0008 0.0038
Brugia malayi hypothetical protein 0.0038 0.0034 0.026
Onchocerca volvulus 0.0038 0.0034 0.0705
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0343 0.0482 0.3691
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Giardia lamblia Hypothetical protein 0.0132 0.0172 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0882 0.6736
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0043
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0028 0.0028
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0058 0.0382
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0129 0.0983
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904 0.1305 0.3764
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0334 0.0469 0.0468
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0376 0.053 0.5782
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0035 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0013 0.0065
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0148 0.0195 0.0556
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0148 0.0845
Schistosoma mansoni regulator of G protein signaling 0.002 0.0008 0.0038
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0028 0.0028
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0008 0.0008
Entamoeba histolytica casein kinase, putative 0.0146 0.0193 0.1425
Entamoeba histolytica serine/threonine protein kinase, putative 0.0205 0.0279 0.2087
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0008 0.0038
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0058 0.1851
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0132 0.0172 0.0489
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.002 0.0149
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0058 0.0291
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0118 0.0595
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0904 0.1305 1
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0035 0.1127
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0132 0.0172 0.1817
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0227 0.0311 0.3356
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0137
Trypanosoma brucei protein kinase, putative 0.0054 0.0058 0.0549
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0148 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.0172 0.1267
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0616 0.0882 0.2405
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0132 0.0172 0.5533
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0008 0.0008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0625 0.0896 0.2581
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0132 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.0817 0.6236
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0205 0.0279 0.0278
Echinococcus granulosus expressed conserved protein 0.0087 0.0106 0.0105
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0334 0.0469 0.1347
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0227 0.0311 0.3557
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0343 0.0482 0.275
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0227 0.0311 0.2337
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0013 0.0065
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0583 0.0834 0.2273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0024 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0132 0.0172 0.1317
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0227 0.0311 0.0843
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0635 0.091 0.4619
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0024 0.0123
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0034 0.0261
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0315
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0065 0.0074 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.2374 0.3462 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0043
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0132 0.0172 0.0872
Toxoplasma gondii hypothetical protein 0.0021 0.0008 0.0095
Entamoeba histolytica hypothetical protein 0.0038 0.0034 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0132 0.0172 0.0172
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0343 0.0482 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0058 0.0328
Schistosoma mansoni axis inhibition protein axin 0.002 0.0008 0.0038
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0343 0.0482 0.0481
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.0214 0.1221
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0023 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0882 0.6736
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0093 0.0093
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.0172 0.1267
Onchocerca volvulus 0.0053 0.0055 0.1143
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0008 0.0008
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0616 0.0882 0.9681
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0024 0.0273
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0282 0.0391 0.4142
Echinococcus multilocularis serine protein kinase ATM 0.035 0.0492 0.0491
Trypanosoma cruzi target of rapamycin kinase 3 0.0616 0.0882 0.254
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0853 0.6514
Brugia malayi Pre-SET motif family protein 0.0032 0.0024 0.0184
Leishmania major cytochrome p450-like protein 0.0021 0.0008 0.0014
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0008 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0635 0.091 0.2624
Schistosoma mansoni fkbp-rapamycin associated protein 0.0334 0.0469 0.2377
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Entamoeba histolytica hypothetical protein 0.0132 0.0172 0.1267
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0107
Echinococcus multilocularis survival motor neuron protein 1 0.0504 0.0717 0.0716
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0526 0.075 0.8195
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.0000000058483
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0024 0.076
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0676 0.0969 0.7412
Brugia malayi follicle stimulating hormone receptor 0.0257 0.0355 0.272
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0132 0.0172 0.1969
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0904 0.1305 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0035 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0008 0.0045
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0004 0.0019
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0024 0.0273
Loa Loa (eye worm) hypothetical protein 0.037 0.052 0.2968
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.0279 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0845 0.6457
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0132 0.0172 0.5533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0845 0.6457
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0148 0.1083
Echinococcus multilocularis lamin 0.0029 0.002 0.0019
Onchocerca volvulus 0.0029 0.002 0.0403
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0427 0.0605 0.3068
Loa Loa (eye worm) phosphatidylinositol 3 0.0635 0.091 0.5197
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.0274 0.2054
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0635 0.091 0.2484
Leishmania major phosphatidylinositol kinase related protein, putative 0.0148 0.0195 0.0526
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0008 0.0008
Toxoplasma gondii ck2 beta subunit 0.0039 0.0035 0.0404
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0227 0.0311 0.0311
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0635 0.091 0.6976
Plasmodium vivax SET domain protein, putative 0.0032 0.0024 0.0772
Schistosoma mansoni hypothetical protein 0.0237 0.0326 0.1652
Loa Loa (eye worm) hypothetical protein 0.0299 0.0417 0.2381
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0034 0.1861
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0074 0.0506
Loa Loa (eye worm) hypothetical protein 0.0218 0.0297 0.1696
Schistosoma mansoni intermediate filament proteins 0.0029 0.002 0.0099
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0635 0.091 0.091
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0132 0.0172 0.1267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.0274 0.2054
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0008 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0846 0.6458
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0058 0.0661
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0058 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Echinococcus multilocularis geminin 0.018 0.0242 0.0241
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0148 0.0751
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0132 0.0172 0.1267
Onchocerca volvulus 0.0132 0.0172 0.3569
Onchocerca volvulus 0.0132 0.0172 0.3569
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0043
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0008 0.0015
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0008 0.0008
Brugia malayi 6-phosphofructokinase 0.0116 0.0148 0.1135
Onchocerca volvulus 0.0029 0.002 0.0403
Onchocerca volvulus 0.0054 0.0058 0.1193
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Echinococcus granulosus expressed protein 0.0399 0.0563 0.0563
Schistosoma mansoni hypothetical protein 0.0103 0.0129 0.0651
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0008 0.0058
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0008 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0062 0.0415
Entamoeba histolytica hypothetical protein 0.035 0.0492 0.373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.002 0.0111
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0013 0.0074
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0039 0.0035 0.03
Entamoeba histolytica hypothetical protein 0.0038 0.0034 0.0203
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0227 0.0311 0.2337
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0029 0.002 0.0152
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0008 0.0008
Onchocerca volvulus 0.0107 0.0135 0.2805
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0095 0.0118 0.0117
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0334 0.0469 0.0468
Brugia malayi Serotonin receptor 0.0503 0.0716 0.5486
Echinococcus granulosus serine protein kinase ATM 0.035 0.0492 0.0491
Plasmodium vivax unspecified product 0.0146 0.0193 0.6192
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.035 0.0492 0.2494
Loa Loa (eye worm) gastrulation defective protein 1 0.0139 0.0182 0.104
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0008 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.0817 0.6236
Brugia malayi Cytochrome P450 family protein 0.0021 0.0008 0.0061
Giardia lamblia Kinase, PLK 0.0205 0.0279 0.2873
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0653 0.0937 0.0936
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0035 0.0725
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0148 0.042
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0227 0.0311 0.2381
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0148 0.1083
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0055 0.0279
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.002 0.0094
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0008 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0023
Entamoeba histolytica protein kinase, putative 0.0054 0.0058 0.0385
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0205 0.0279 0.1589
Loa Loa (eye worm) hypothetical protein 0.0237 0.0326 0.1859
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1358 0.197 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0334 0.0469 0.3553
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0093 0.0093
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0453 0.0643 0.4929
Schistosoma mansoni lamin 0.0029 0.002 0.0099
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0093 0.0114 0.0576
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0008 0.0008
Loa Loa (eye worm) Csnk2b protein 0.0039 0.0035 0.02
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0058 0.0385
Loa Loa (eye worm) RGS-3 protein 0.002 0.0008 0.0043
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0148 0.8546
Loa Loa (eye worm) hypothetical protein 0.0174 0.0234 0.1334
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0132 0.0172 0.0489
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0008 0.0038
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0389 0.0549 0.5994
Schistosoma mansoni kinase 0.0106 0.0133 0.0672
Schistosoma mansoni hypothetical protein 0.0132 0.0172 0.0872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0846 0.6458
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0074 0.0506
Schistosoma mansoni lamin 0.0029 0.002 0.0099
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0635 0.091 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0008 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0058 0.0385
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0058 0.0328
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0065 0.0074 0.0073
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0051 0.0053 0.0299
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0343 0.0482 0.0481
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0008 0.0008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0028 0.0141
Schistosoma mansoni single-minded 0.0052 0.0054 0.0273
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000029685
Loa Loa (eye worm) phosphatidylinositol 3 0.0132 0.0172 0.0981
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0572 0.0817 0.8961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0882 0.6736
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0011 0.0024
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0132 0.0172 0.1267
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0008 0.0058
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0074 0.0204
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0008 0.0007
Schistosoma mansoni regulator of G protein signaling 0.002 0.0008 0.0038
Echinococcus multilocularis expressed protein 0.0399 0.0563 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0062 0.0415
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0024 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Brugia malayi hypothetical protein 0.0108 0.0136 0.1037
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0008 0.0095
Entamoeba histolytica hypothetical protein 0.0038 0.0034 0.0203
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.091 0.6958
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0625 0.0896 0.4544
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0346 0.0486 0.3683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.0526 0.3997
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0132 0.0172 0.1267
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0146 0.0193 0.6192
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0028 0.0028
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0132 0.0172 0.0872
Toxoplasma gondii non-specific serine/threonine protein kinase 0.037 0.052 0.5949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0414 0.0585 0.445
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0326 0.2451
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.0074 0.0724
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0625 0.0896 0.0895
Echinococcus granulosus geminin 0.018 0.0242 0.0241
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0376 0.053 0.4024
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0024 0.0273
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0132 0.0172 0.1817
Leishmania major phosphatidylinositol 3-kinase, putative 0.0227 0.0311 0.0843
Toxoplasma gondii FATC domain-containing protein 0.035 0.0492 0.5624
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0237 0.0326 0.0325
Echinococcus multilocularis expressed conserved protein 0.0087 0.0106 0.0105
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.035 0.0492 0.3767
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0024 0.0024
Echinococcus granulosus axis inhibition protein axin 0.002 0.0008 0.0008
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0904 0.1305 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0011 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0148 0.1083
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0054 0.0273
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0095 0.0118 0.0117
Brugia malayi PXA domain containing protein 0.0022 0.001 0.0075
Loa Loa (eye worm) hypothetical protein 0.0504 0.0717 0.4092
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0035 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0193 0.1425
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0755 0.1086 0.8312
Brugia malayi Protein kinase domain containing protein 0.0019 0.0006 0.0041
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0191 0.0258 0.1473
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Brugia malayi intracellular kinase 0.0054 0.0058 0.0441
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0904 0.1305 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0227 0.0311 0.0891
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.0469 0.359
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0024 0.0123
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0148 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0456 0.0647 0.4924
Loa Loa (eye worm) RecQ helicase 0.0023 0.0011 0.0061
Brugia malayi 6-phosphofructokinase 0.0116 0.0148 0.1135
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0028 0.0141
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0227 0.0311 0.1577
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0074 0.0506
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0676 0.0969 0.7412
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0013 0.0065
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0008 0.0008
Echinococcus multilocularis casein kinase ii subunit alpha 0.0146 0.0193 0.0192
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0035 0.0211
Schistosoma mansoni hypothetical protein 0.0038 0.0034 0.0172
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0227 0.0311 0.0891
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0074 0.0506
Leishmania major hypothetical protein, conserved 0.2506 0.3656 1
Plasmodium vivax hypothetical protein, conserved 0.0132 0.0172 0.5533
Brugia malayi FAT domain containing protein 0.0237 0.0326 0.2495
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0008 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0132 0.0172 0.1969
Schistosoma mansoni hypothetical protein 0.0055 0.0058 0.0294
Brugia malayi PXA domain containing protein 0.0022 0.001 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0874 0.668
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0024 0.0278
Onchocerca volvulus 0.0251 0.0347 0.7192
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0008 0.0058
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0227 0.0311 0.3557
Brugia malayi Casein kinase II, alpha chain 0.0146 0.0193 0.1475
Echinococcus multilocularis Zinc finger, PHD finger 0.0227 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0108 0.0136 0.0773
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0043 0.0116
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0148 0.1553
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0148 0.0398
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0035 0.1127
Echinococcus multilocularis cyclin dependent kinase 19 0.0143 0.0188 0.0187
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0132 0.0172 0.5434
Echinococcus granulosus protein kinase shaggy 0.0054 0.0058 0.0057
Schistosoma mansoni survival motor neuron protein 0.0103 0.0129 0.0651
Loa Loa (eye worm) hypothetical protein 0.0107 0.0135 0.0772
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0043
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.002 0.0152
Loa Loa (eye worm) phosphatidylinositol 3 0.0244 0.0335 0.1914
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0132 0.0172 0.5533
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Brugia malayi Csnk2b protein 0.0039 0.0035 0.0268
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0043 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.0526 0.3997
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211
Brugia malayi hypothetical protein 0.0174 0.0234 0.179
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0062 0.0415
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0376 0.053 0.4024
Leishmania major hypothetical protein, unknown function 0.0132 0.0172 0.0463
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.001 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.0817 0.6236
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.0279 0.2087
Onchocerca volvulus Serine\/threonine kinase homolog 0.0205 0.0279 0.5778
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0046
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0205 0.0279 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0853 0.6514
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0035 0.0211

Activities

Activity type Activity value Assay description Source Reference
APTT (functional) ND 0 IU mg-1 In vitro anticoagulant activity determined by clotting test of activated partial thromboplastintime (APTT) on a pool of human plasma ChEMBL. 8246223
EC50 (functional) = 3.3 ug ml-1 Effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 ChEMBL. 8246223
EC50 (functional) = 3.3 ug ml-1 Effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 ChEMBL. 8246223
EC50 (functional) = 20 ug ml-1 Giant-cell formation between persistently HIV-1 infected HUT-78 cells and uninfected MOLT-4 cells ChEMBL. 8246223
EC50 (functional) = 20 ug ml-1 Giant-cell formation between persistently HIV-1 infected HUT-78 cells and uninfected MOLT-4 cells ChEMBL. 8246223
EC50 (functional) > 23.2 ug ml-1 Effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-2 ChEMBL. 8246223
EC50 (functional) > 23.2 ug ml-1 Effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-2 ChEMBL. 8246223
Selectivity index (functional) > 1 Selectivity index for CC50 (cytotoxic concentration based on reduction of viability of mock-infected MT-4 cells) to that of EC50 against HIV-2 ChEMBL. 8246223
Selectivity index (functional) = 6 Selectivity index for CC50 (cytotoxic concentration based on the reduction of the viability of mock-infected MT-4 cells) to that of EC50 against HIV-1 ChEMBL. 8246223

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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