Detailed information for compound 42435

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.492 | Formula: C18H28N2O2S
  • H donors: 0 H acceptors: 2 LogP: 3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CS(=O)(=O)N([C@@H]1CCN2[C@@H](C1)c1ccccc1CC2)C)C
  • InChi: 1S/C18H28N2O2S/c1-14(2)13-23(21,22)19(3)16-9-11-20-10-8-15-6-4-5-7-17(15)18(20)12-16/h4-7,14,16,18H,8-13H2,1-3H3/t16-,18+/m1/s1
  • InChiKey: ASJBFSIEEDXKAI-AEFFLSMTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0139 0.0215
Trichomonas vaginalis guanylate cyclase, putative 0.014 0.0812 0.2681
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0139 0.0138
Schistosoma mansoni DNA helicase recq1 0.0028 0.0091 0.009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0275 0.0349
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.014 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0033
Entamoeba histolytica hypothetical protein 0.0019 0.0031 0.0926
Echinococcus granulosus sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0018 0.0021 0.0006
Echinococcus granulosus expressed protein 0.0373 0.2318 0.3107
Echinococcus granulosus orexin receptor type 2 0.0036 0.014 0.0166
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0257 0.0347
Echinococcus granulosus g-protein coupled receptor 0.0036 0.014 0.0166
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0018 0.0021 0.0006
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0031 0.0019
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0051 0.0046
Toxoplasma gondii hypothetical protein 0.0018 0.0021 0.0194
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.014 0.0812 1
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0026 0.0012
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0076 0.008
Echinococcus multilocularis lamin dm0 0.0054 0.0257 0.0324
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0026 0.004
Brugia malayi Cytochrome P450 family protein 0.0023 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi nuclear receptor NHR-67 0.0017 0.0017 0.0026
Onchocerca volvulus 0.0036 0.014 0.0189
Onchocerca volvulus 0.0036 0.014 0.0189
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0035 0.036
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.014 0.0189
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.014 0.0812 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0031 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0139 0.0188
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.014 0.0189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0139 0.0215
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0026 0.004
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0035 0.0054
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0017 0.0023
Trichomonas vaginalis rotamase, putative 0.0033 0.0118 0.0298
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0264 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.014 0.0166
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.1409 0.1408
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1103 0.1102
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0018 0.0021 0.0006
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0139 0.0188
Echinococcus granulosus lamin 0.0054 0.0257 0.0324
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Schistosoma mansoni biogenic amine receptor 0.0036 0.014 0.0139
Brugia malayi hypothetical protein 0.0019 0.003 0.0046
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0051 0.0787
Echinococcus granulosus nAChR subunit 0.0018 0.0026 0.0012
Echinococcus granulosus lamin dm0 0.0054 0.0257 0.0324
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.014 0.0166
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0017 0.0026
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0095 0.0146
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0139 0.0165
Echinococcus granulosus g protein coupled receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Cation transporter family protein 0.0018 0.0026 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Brugia malayi Dopamine receptor protein 2 0.0036 0.014 0.0216
Schistosoma mansoni rotamase 0.0033 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0031 0.003
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0586 0.3693 0.4963
Onchocerca volvulus Ribonuclease H1 homolog 0.0025 0.0066 0.0089
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0139 0.0165
Brugia malayi Pre-SET motif family protein 0.006 0.0294 0.0452
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0026 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0139 0.0188
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0256 0.1559 0.1558
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0094
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0108 0.0263
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.014 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Schistosoma mansoni lamin 0.0054 0.0257 0.0256
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0161 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0068
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0393 0.0606
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni phosphoglucomutase 0.0025 0.0066 0.0065
Schistosoma mansoni adenoreceptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0091 0.01
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0273 0.2474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0066 0.0803
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi RE15519p 0.0036 0.014 0.0216
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni rab6-interacting 0.002 0.0035 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.014 0.0166
Schistosoma mansoni nuclear receptor 0.0017 0.0017 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.1495
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.2549 0.3418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0022 0.0051 0.0068
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.014 0.0216
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0001 0.001
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.014 0.0166
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0017 0.0016
Echinococcus granulosus neuropeptide receptor 0.0036 0.014 0.0166
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.015 0.0179
Onchocerca volvulus 0.0036 0.014 0.0189
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0326 0.1818
Schistosoma mansoni opsin-like receptor 0.0036 0.014 0.0139
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0161 0.0468
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.014 0.0166
Brugia malayi CXXC zinc finger family protein 0.0029 0.0093 0.0143
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0936
Echinococcus multilocularis serotonin receptor 0.0036 0.014 0.0166
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0091 0.01
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1799 0.1798
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0017 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.014 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.003 0.0046
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.024 0.0239
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0031 0.0042
Onchocerca volvulus 0.0051 0.024 0.0325
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0031 0.003
Schistosoma mansoni biogenic amine receptor 0.0036 0.014 0.0139
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0054 0.0257 0.0347
Trypanosoma brucei ingi protein (ORF1) 0.003 0.0102 0.0252
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.014 0.0189
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0171 0.0263
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0077 0.0698
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0064 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0031 0.003
Echinococcus granulosus tumor protein p63 0.0352 0.2181 0.2921
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0017 0.0026
Schistosoma mansoni sodium/chloride dependent transporter 0.0018 0.0021 0.002
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0026 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni nuclear receptor 0.0017 0.0017 0.0016
Onchocerca volvulus 0.0104 0.0579 0.0783
Schistosoma mansoni hypothetical protein 0.0037 0.0149 0.0148
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0031 0.0019
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.014 0.0166
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0047
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0031 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0315 0.0314
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0026 0.0012
Brugia malayi putative neuropeptide receptor 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0139 0.0215
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0064 0.0063
Entamoeba histolytica hypothetical protein 0.0019 0.0031 0.0926
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Schistosoma mansoni sodium/chloride dependent transporter 0.0104 0.0579 0.0578
Schistosoma mansoni slit 0.0024 0.0064 0.0063
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0026 0.004
Echinococcus multilocularis orexin receptor type 2 0.0036 0.014 0.0166
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0026 0.004
Brugia malayi Kringle domain containing protein 0.0022 0.0051 0.0078
Schistosoma mansoni loxhd1 0.002 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.014 0.0166
Schistosoma mansoni cpg binding protein 0.0029 0.0093 0.0092
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0026 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0139 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1103 0.4362
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.014 0.0166
Brugia malayi hypothetical protein 0.0019 0.0031 0.0048
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0018 0.0021 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Onchocerca volvulus 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.014 0.0812 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0139 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.014 0.0166
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0026 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0294 0.0292
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0326 0.2616
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.014 0.0166
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0141
Schistosoma mansoni hypothetical protein 0.0257 0.1567 0.1566
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.0783
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0035 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0812 0.2681
Echinococcus granulosus voltage dependent calcium channel subunit 0.0266 0.1629 0.2177
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.1103 0.1466
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0139 0.0165
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0326 0.0441
Onchocerca volvulus 0.0018 0.0021 0.0029
Schistosoma mansoni hypothetical protein 0.0022 0.0051 0.005
Schistosoma mansoni biogenic amine receptor 0.0036 0.014 0.0139
Echinococcus granulosus somatostatin receptor 0.0036 0.014 0.0166
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Schistosoma mansoni ap endonuclease 0.0039 0.0161 0.016
Brugia malayi larval opioid receptor 0.0036 0.014 0.0216
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0026 0.0012
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.014 0.0166
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Loa Loa (eye worm) hypothetical protein 0.0051 0.024 0.0325
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Brugia malayi steroid hormone receptor 0.0036 0.0139 0.0215
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.014 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus g protein coupled receptor 0.0036 0.014 0.0166
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0139 0.0138
Brugia malayi hypothetical protein 0.0026 0.0077 0.0119
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Brugia malayi nuclear receptor NHR-88 0.0036 0.0139 0.0215
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.014 0.0166
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0091 0.01
Brugia malayi hypothetical protein 0.0019 0.0031 0.0048
Toxoplasma gondii hypothetical protein 0.0018 0.0021 0.0194
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi tailless protein 0.0017 0.0017 0.0026
Echinococcus multilocularis serotonin receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0026 0.0035
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0026 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.0783
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0031 0.0042
Treponema pallidum ribonuclease H (rnhA) 0.0025 0.0066 0.0191
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0031 0.0048
Echinococcus multilocularis allatostatin A receptor 0.0036 0.014 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus granulosus fmrfamide receptor 0.0036 0.014 0.0166
Brugia malayi neuropeptide F receptor 0.0036 0.014 0.0216
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0161 0.1971
Toxoplasma gondii exonuclease III APE 0.0039 0.0161 0.1459
Onchocerca volvulus 0.0403 0.2513 0.3399
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.014 0.0139
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.014 0.0812 0.2681
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0139 0.0215
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0264 0.0334
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.003 0.0029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0017 0.0023
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.014 0.0166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.014 0.0139
Brugia malayi G protein-coupled receptor 0.0036 0.014 0.0216
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Brugia malayi conserved hypotetical protein 0.0017 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.014 0.0216
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0026 0.0012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Brugia malayi neuropeptide F receptor 0.0036 0.014 0.0216
Toxoplasma gondii ribonuclease HI protein 0.0025 0.0066 0.06
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0161 0.0218
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0118 0.107
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0139 0.0188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.0409 0.2549 0.2548
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.014 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0161 0.0663
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0161 0.0446
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni lipoxygenase 0.002 0.0035 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.1495
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Trichomonas vaginalis rotamase, putative 0.0033 0.0123 0.0316
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0149 0.0179
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.014 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0104 0.0579 0.0578
Schistosoma mansoni ap endonuclease 0.0039 0.0161 0.016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0026 0.004
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0026 0.0012
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0035 0.0048
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0031 0.0019
Onchocerca volvulus 0.006 0.0294 0.0397
Onchocerca volvulus 0.002 0.0035 0.0047
Schistosoma mansoni coup transcription factor 0.0036 0.0139 0.0138
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.014 0.0166
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0139 0.0165
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Schistosoma mansoni phosphoglucomutase 0.0025 0.0066 0.0065
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0021 0.002
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.014 0.0166
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0294 0.0374
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0104 0.0579 0.0892
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.014 0.0216
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0031 0.0042
Brugia malayi EGF-like domain containing protein 0.0024 0.0064 0.0098
Echinococcus multilocularis cpg binding protein 0.003 0.0103 0.0117
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0077 0.1495
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.014 0.0189
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni intermediate filament proteins 0.0054 0.0257 0.0256
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0076 0.008
Brugia malayi nuclear receptor NHR-88 0.0017 0.0017 0.0026
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1103 0.1102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0326 0.0325
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0154 0.3572
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0294 0.2661
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0118 0.0641
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0294 0.0292
Brugia malayi Serotonin receptor 0.0036 0.014 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Echinococcus multilocularis RUN 0.002 0.0035 0.0024
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0118 0.1442
Schistosoma mansoni hypothetical protein 0.0138 0.0797 0.0796
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.1409 0.188
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.003 0.0046
Loa Loa (eye worm) doublecortin family protein 0.002 0.0035 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.014 0.0166
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.014 0.0139
Echinococcus granulosus transcription factor Dp 1 0.0037 0.015 0.0179
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0051 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0036 0.014 0.0166
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0051 0.0459
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) norepinephrine transporter 0.0104 0.0579 0.0783
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0026 0.004
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0026 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0139 0.0138
Brugia malayi RNase H family protein 0.0025 0.0066 0.0102
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0026 0.0035
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0145 0.0842 0.1139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.1799 0.2406
Onchocerca volvulus 0.1159 0.7394 1
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.014 0.0166
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.014 0.0166
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0031 0.0019
Echinococcus granulosus pikachurin 0.0024 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0139 0.0165
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.1103 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.1567 0.2093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0139 0.0188
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.014 0.0166
Brugia malayi hypothetical protein 0.0122 0.0694 0.1069
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Echinococcus multilocularis ribonuclease H1 0.0025 0.0066 0.0067
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.014 0.0166
Brugia malayi Cation transporter family protein 0.0018 0.0026 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni cpg binding protein 0.003 0.0103 0.0102
Schistosoma mansoni opsin-like receptor 0.0036 0.014 0.0139
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0026 0.0025
Trypanosoma brucei ingi protein (ORF1) 0.003 0.0102 0.0252
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0123 0.019
Echinococcus granulosus serotonin transporter 0.0104 0.0579 0.0759
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.014 0.0139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0139 0.0215
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.014 0.0139
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0031 0.0048
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus multilocularis serotonin transporter 0.0104 0.0579 0.0759
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0021 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Brugia malayi follicle stimulating hormone receptor 0.0036 0.014 0.0216
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0026 0.0025
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0542 0.3413 1
Trichomonas vaginalis adenylate cyclase, putative 0.014 0.0812 0.2681
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0031 0.0019
Trichomonas vaginalis ribonuclease H1, putative 0.0025 0.0066 0.012
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0031 0.003
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.014 0.0166
Echinococcus multilocularis lamin 0.0054 0.0257 0.0324
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0031 0.0019
Leishmania major ribonuclease H1, putative 0.0025 0.0066 0.0148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0161 0.1971
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0123 0.0316
Onchocerca volvulus 0.0018 0.0026 0.0035
Brugia malayi nuclear hormone receptor 0.0036 0.0139 0.0215
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0118 0.3599
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0026 0.0035
Echinococcus granulosus serotonin receptor 0.0036 0.014 0.0166
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.1314
Brugia malayi Cache domain containing protein 0.0118 0.067 0.1032
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0108 0.3281
Echinococcus multilocularis fmrfamide receptor 0.0036 0.014 0.0166
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0035 0.036
Loa Loa (eye worm) hypothetical protein 0.1019 0.649 0.8777
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0031 0.003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0033
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0031 0.0042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0061 0.0549
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0149 0.0179
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0161 0.0514
Mycobacterium leprae Possible regulatory protein 0.014 0.0812 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Serotonin receptor 0.0036 0.014 0.0216
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Brugia malayi PXA domain containing protein 0.0019 0.0031 0.0048
Brugia malayi PXA domain containing protein 0.0019 0.0031 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0827
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0145 0.0842 0.1114
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0033
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0171 0.0479
Brugia malayi nuclear receptor RXR 0.0019 0.003 0.0046
Brugia malayi G-protein coupled receptor 0.0036 0.014 0.0216
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.014 0.0139
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0031 0.0048
Plasmodium vivax SET domain protein, putative 0.006 0.0294 0.7316
Treponema pallidum sodium- and chloride- dependent transporter 0.0104 0.0579 0.1693
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0294 0.0374
Echinococcus multilocularis slit 2 protein 0.0024 0.0064 0.0063
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0018 0.0021 0.0006
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.014 0.0216
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0018 0.0021 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.014 0.0189
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0161 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0031 0.0019
Echinococcus multilocularis geminin 0.0169 0.1002 0.133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1103 0.4362
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0017 0.0017 0.0023
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0031 0.0048
Echinococcus granulosus slit 2 protein 0.0024 0.0064 0.0063
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0393 0.3355
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0139 0.0215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0139 0.0165
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0086
Brugia malayi intermediate filament protein 0.0054 0.0257 0.0396
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0064 0.115
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Echinococcus multilocularis expressed protein 0.0373 0.2318 0.3107
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0017 0.0023
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.014 0.0812 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0021 0.002
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0031 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.014 0.0189
Brugia malayi laminin alpha chain 0.0024 0.0064 0.0098
Echinococcus multilocularis g protein coupled receptor 0.0036 0.014 0.0166
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0017 0.0016
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0118 0.0363
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.014 0.0166
Onchocerca volvulus 0.0018 0.0021 0.0029
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.014 0.0139
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.2575 0.3483
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0048
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0031 0.0019
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Schistosoma mansoni serine-rich repeat protein 0.0138 0.0797 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0139 0.0215
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0053 0.0251 0.0339
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni histamine h1 receptor 0.0036 0.014 0.0139
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Echinococcus multilocularis fmrfamide receptor 0.0036 0.014 0.0166
Onchocerca volvulus 0.0018 0.0026 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0257 0.0347
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0031 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.014 0.0166
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0066 0.0803
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0021 0.002
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0064 0.0098
Schistosoma mansoni DNA helicase recq5 0.0028 0.0091 0.009
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0317 0.1956 0.2646
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0827
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Onchocerca volvulus 0.0018 0.0021 0.0029
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0026 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.1103 0.1466
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0326 0.4007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0139 0.0165
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni hypothetical protein 0.0169 0.1002 0.1001
Schistosoma mansoni cell polarity protein 0.0024 0.0064 0.0063
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0018 0.0021 0.002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.014 0.0216
Schistosoma mansoni phosphoglucomutase 0.0025 0.0066 0.0065
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0031 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0047
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0266 0.1629 0.2177
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0034
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi hypothetical protein 0.0018 0.0021 0.0033
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0091 0.0123
Brugia malayi aryl hydrocarbon receptor AHR-1 0.1019 0.649 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Brugia malayi Melatonin receptor type 1A 0.0036 0.014 0.0216
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.1159 0.7394 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.014 0.0216
Entamoeba histolytica hypothetical protein 0.0019 0.0031 0.0926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0294 0.0292
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0139 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0139 0.0215
Echinococcus multilocularis sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0017 0.0016
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0026 0.004
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0091 0.2646
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0094
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Toxoplasma gondii endonuclease IV APN 0.0075 0.0393 0.3567
Echinococcus granulosus single minded 2 0.0399 0.2483 0.3329
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.014 0.0812 0.2681
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0161 0.492
Brugia malayi bHLH-PAS transcription factor 0.0399 0.2483 0.3826
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0104
Schistosoma mansoni hypothetical protein 0.0169 0.1002 0.1001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0139 0.0165
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) serotonin transporter b 0.0104 0.0579 0.0783
Schistosoma mansoni single-minded 0.0539 0.3388 0.3387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0051 0.0068
Schistosoma mansoni lipoxygenase 0.0055 0.0264 0.0263
Echinococcus multilocularis nAChR subunit 0.0018 0.0026 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.0542
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0031 0.003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0029
Onchocerca volvulus 0.0018 0.0026 0.0035
Brugia malayi Dopamine receptor 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0031 0.0019
Schistosoma mansoni myosin xvIII 0.0036 0.014 0.0139
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.014 0.0139
Echinococcus granulosus hypothetical protein 0.0036 0.014 0.0166
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0018 0.0021 0.0006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.014 0.0812 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.1023 0.652 0.8817
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0139 0.0138
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0139 0.0165
Leishmania major hypothetical protein, conserved 0.0026 0.0077 0.025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0139 0.0188
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0035 0.0024
Brugia malayi ORL1-like opioid receptor 0.0036 0.014 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) RecQ helicase 0.0041 0.0171 0.0231
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0139 0.0138
Loa Loa (eye worm) DR-78 0.0017 0.0017 0.0023
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.014 0.0139
Schistosoma mansoni polycystin 1-related 0.002 0.0035 0.0034
Brugia malayi Cation transporter family protein 0.0018 0.0026 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0139 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.014 0.0166
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0194
Schistosoma mansoni lamin 0.0054 0.0257 0.0256
Echinococcus granulosus geminin 0.0169 0.1002 0.133
Onchocerca volvulus 0.0054 0.0257 0.0347
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0194
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0145 0.0842 0.1114
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0091 0.1879
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.014 0.0216
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0171 0.0208
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0123 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0161 0.0195
Echinococcus granulosus RUN 0.002 0.0035 0.0024
Echinococcus multilocularis musashi 0.0054 0.0257 0.0324
Leishmania major protein kinase, putative 0.014 0.0812 0.7234
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0326 0.0417
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Onchocerca volvulus 0.0018 0.0026 0.0035
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.014 0.0166
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0149 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0036 0.014 0.0166
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0326 0.4007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.003 0.0018
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Leishmania major protein kinase, putative 0.014 0.0812 0.7234
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.1409 0.188
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.014 0.0812 0.2681
Echinococcus multilocularis transfer RNA-Lys 0.0399 0.2483 0.3329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.014 0.0189
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Brugia malayi hypothetical protein 0.014 0.0812 0.1251
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0026 0.004
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.014 0.0812 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0139 0.0188
Brugia malayi PAS domain containing protein 0.0539 0.3388 0.522
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus allatostatin A receptor 0.0036 0.014 0.0166
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.0783
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Echinococcus multilocularis pikachurin 0.0024 0.0064 0.0063
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0031 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0161 0.0195
Trichomonas vaginalis guanylate cyclase, putative 0.014 0.0812 0.2681
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0031 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0294 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Echinococcus multilocularis g protein coupled receptor 0.0036 0.014 0.0166
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.003 0.0018
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0064 0.0063
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0021 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0139 0.0165
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0393 0.4612
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0031 0.0019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0118 0.1442
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.014 0.0166
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0139 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0051 0.0611
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0161 0.1178
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.003 0.004
Trypanosoma brucei unspecified product 0.003 0.0102 0.0252
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0161 0.0446
Echinococcus granulosus intermediate filament protein 0.0054 0.0257 0.0324
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0257 0.0396
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0031 0.0019
Onchocerca volvulus 0.0036 0.014 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0812 0.2681
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0026 0.0012
Schistosoma mansoni hypothetical protein 0.0246 0.1495 0.1494
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0812 0.2681
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0026 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0161 0.3752
Brugia malayi ecdysteroid receptor 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0075 0.0393 0.0532
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0026 0.0012
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.014 0.0166
Echinococcus granulosus bloom syndrome protein 0.0041 0.0171 0.0208
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0017 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0139 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0294 0.0374
Echinococcus multilocularis sex peptide receptor 0.0036 0.014 0.0166
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0393 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.1567 0.2093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.014 0.0166
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0141
Brugia malayi hypothetical protein 0.0019 0.003 0.0046
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0326 1
Echinococcus granulosus sex peptide receptor 0.0036 0.014 0.0166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0161 0.1048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Onchocerca volvulus Putative nachr subunit 0.0018 0.0026 0.0035
Trypanosoma brucei RNA helicase, putative 0.0246 0.1495 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0036 0.014 0.0189
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0109
Loa Loa (eye worm) hypothetical protein 0.014 0.0812 0.1098
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0171 0.0479
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0026 0.0012
Brugia malayi sulfakinin receptor protein 0.0036 0.014 0.0216
Brugia malayi Pre-SET motif family protein 0.0413 0.2575 0.3968
Echinococcus granulosus voltage dependent calcium channel subunit 0.0586 0.3693 0.4963
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0026 0.0035
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.014 0.0812 0.7234
Brugia malayi hypothetical protein 0.0107 0.0598 0.0921
Brugia malayi hypothetical protein 0.002 0.0035 0.0054
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.014 0.0166
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0031 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0054 0.0257 0.0347
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.014 0.0166
Brugia malayi nuclear hormone receptor 0.0017 0.0017 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Chlamydia trachomatis endonuclease IV 0.0075 0.0393 0.4706
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.014 0.0189
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0018 0.0021 0.0033
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0021 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.014 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Mycobacterium ulcerans putative regulatory protein 0.0399 0.2483 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0936
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.1103 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi nuclear receptor RXR 0.0017 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0086
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0102 0.0252
Onchocerca volvulus 0.0029 0.0093 0.0126
Echinococcus granulosus aryl hydrocarbon receptor 0.1163 0.7424 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0161 0.3752
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Brugia malayi hypothetical protein 0.002 0.0035 0.0054
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0026 0.0025
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.014 0.0812 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.014 0.0139
Echinococcus multilocularis somatostatin receptor 0.0036 0.014 0.0166
Onchocerca volvulus 0.0018 0.0026 0.0035
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0051 0.0787
Echinococcus multilocularis tumor protein p63 0.0352 0.2181 0.2921
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0054 0.0074
Schistosoma mansoni opsin-like receptor 0.0036 0.014 0.0139
Echinococcus granulosus sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Schistosoma mansoni sodium-dependent amino acid transporter 0.0018 0.0021 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.5144 0.6922
Echinococcus granulosus expressed protein 0.0033 0.0123 0.0143
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0031 0.0048
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.014 0.0166
Echinococcus granulosus neuropeptide s receptor 0.0036 0.014 0.0166
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0007 0.0006
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.014 0.0166
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0031 0.0019
Brugia malayi hypothetical protein 0.0037 0.0149 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.006 0.0294 0.0397
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0093 0.0126
Onchocerca volvulus 0.0036 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus neuropeptide receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Brugia malayi Doublecortin family protein 0.002 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0026 0.004
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0091 0.01
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.014 0.0166
Onchocerca volvulus 0.0017 0.0017 0.0023
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.014 0.0139
Echinococcus multilocularis expressed protein 0.0033 0.0123 0.0143
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0077 0.0076
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0194
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.003 0.0102 0.0252
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.029
Schistosoma mansoni sodium/chloride dependent transporter 0.0018 0.0021 0.002
Brugia malayi GnHR receptor homolog 0.0036 0.014 0.0216
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0035 0.0024
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0017 0.0026
Echinococcus granulosus cpg binding protein 0.003 0.0103 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0139 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0139 0.0188
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.014 0.0812 0.2681
Echinococcus granulosus ribonuclease H1 0.0025 0.0066 0.0067
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0017 0.0026
Brugia malayi G-protein coupled receptor 0.0036 0.014 0.0216
Onchocerca volvulus 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0026 0.0012
Brugia malayi RNase H family protein 0.0025 0.0066 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.014 0.0166
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0064 0.0063
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0026 0.0012
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.014 0.0166
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0095 0.0128
Brugia malayi ecdysone receptor 0.0017 0.0017 0.0026
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.1409 0.1906
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1799 0.1798
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Brugia malayi Dopamine receptor protein 1 0.0036 0.014 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0064 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0139 0.0215
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0326 0.0417
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Mycobacterium ulcerans endonuclease IV 0.0075 0.0393 0.1463
Loa Loa (eye worm) hypothetical protein 0.0118 0.067 0.0906
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0026 0.0012
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0129 0.074 0.0739
Onchocerca volvulus 0.047 0.2943 0.398
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0161 0.0248
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.014 0.0216
Schistosoma mansoni rab6-interacting 0.002 0.0035 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0139 0.0215
Onchocerca volvulus 0.002 0.0035 0.0047
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0035 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0139 0.0138
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0026 0.0012
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0018 0.0021 0.0006
Echinococcus multilocularis aryl hydrocarbon receptor 0.1163 0.7424 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1103 0.4362
Brugia malayi Protein kinase domain containing protein 0.0022 0.0051 0.0078
Echinococcus multilocularis neuropeptide receptor 0.0036 0.014 0.0166
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.014 0.0139
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.014 0.0812 0.2681
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0064 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.014 0.0166
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0031 0.003
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.014 0.0166
Brugia malayi RNase H family protein 0.0025 0.0066 0.0102
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.014 0.0166
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0026 0.0025
Loa Loa (eye worm) solute carrier family 6 member 4 0.0104 0.0579 0.0783
Schistosoma mansoni cpg binding protein 0.003 0.0103 0.0102
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0326 0.0502
Schistosoma mansoni zinc finger protein 0.0017 0.0017 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.1103 1
Echinococcus granulosus g protein coupled receptor 0.0036 0.014 0.0166
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.014 0.0139
Trichomonas vaginalis set domain proteins, putative 0.047 0.2943 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0026 0.0012
Brugia malayi AKH receptor 0.0036 0.014 0.0216
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0139 0.0165
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0017 0.0026
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0393 1
Echinococcus granulosus dnaJ subfamily B 0.0409 0.2549 0.3418
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0026 0.0025

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 6.49 Antagonistic activity against alpha-1 adrenergic receptor in isolated rat anococcygeus muscle ChEMBL. 2838634
Kd (functional) = 6.9 Antagonistic activity against alpha-1 adrenergic receptor in rat vas deferens ChEMBL. 2838634
Kd (functional) = 8.05 Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens ChEMBL. 2838634
Kd (functional) = 8.16 Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens ChEMBL. 2838634
Ki (binding) = -8.04 Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]-yohimbine displacement from rat cortical membrane ChEMBL. 1671705
Ki (binding) = -5.7 Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]-Prazosin displacement from rat cortical membrane ChEMBL. 1671705
Log Ki (binding) = 5.7 Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]-Prazosin displacement from rat cortical membrane ChEMBL. 1671705
Log Ki (binding) = 8.04 Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]-yohimbine displacement from rat cortical membrane ChEMBL. 1671705
pA2 (functional) = 6.49 Antagonistic activity against alpha-1 adrenergic receptor in isolated rat anococcygeus muscle ChEMBL. 2838634
pA2 (functional) = 6.9 Antagonistic activity against alpha-1 adrenergic receptor in rat vas deferens ChEMBL. 2838634
pA2 (functional) = 8.05 Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens ChEMBL. 2838634
pA2 (functional) = 8.16 Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens ChEMBL. 2838634
Ratio (binding) = 47 Selectivity ratio represented as antilog (alpha-2 pA2 - alpha-1 pA2) ChEMBL. 2838634
Selectivity ratio (binding) = 220 Selectivity ratio measured as the pKi (alpha-2) /pKi(alpha-1) receptor values. ChEMBL. 1671705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

2 literature references were collected for this gene.

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