Detailed information for compound 42762

Basic information

Technical information
  • TDR Targets ID: 42762
  • Name: N-[(2S,11bR)-2,3,4,6,7,11b-hexahydro-1H-pyrid o[2,1-a]isoquinolin-2-yl]-N-methylpropane-1-s ulfonamide
  • MW: 322.466 | Formula: C17H26N2O2S
  • H donors: 0 H acceptors: 2 LogP: 2.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCS(=O)(=O)N([C@H]1CCN2[C@H](C1)c1ccccc1CC2)C
  • InChi: 1S/C17H26N2O2S/c1-3-12-22(20,21)18(2)15-9-11-19-10-8-14-6-4-5-7-16(14)17(19)13-15/h4-7,15,17H,3,8-13H2,1-2H3/t15-,17+/m0/s1
  • InChiKey: LJPDFKRYOKWXMQ-DOTOQJQBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2S,11bR)-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl]-N-methyl-propane-1-sulfonamide
  • N-[(2S,11bR)-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl]-N-methyl-1-propanesulfonamide
  • PDSP2_001182

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0019 0.0031 0.0926
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.014 0.0189
Echinococcus granulosus expressed protein 0.0373 0.2318 0.3107
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0018 0.0021 0.0006
Echinococcus granulosus sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Trichomonas vaginalis guanylate cyclase, putative 0.014 0.0812 0.2681
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0275 0.0349
Schistosoma mansoni DNA helicase recq1 0.0028 0.0091 0.009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0139 0.0138
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0051 0.0046
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0031 0.0019
Toxoplasma gondii hypothetical protein 0.0018 0.0021 0.0194
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.014 0.0812 1
Echinococcus granulosus orexin receptor type 2 0.0036 0.014 0.0166
Echinococcus granulosus g-protein coupled receptor 0.0036 0.014 0.0166
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0018 0.0021 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0257 0.0347
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.014 0.0189
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.014 0.0812 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0035 0.036
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi nuclear receptor NHR-67 0.0017 0.0017 0.0026
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi Cytochrome P450 family protein 0.0023 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0139 0.0188
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0031 0.0019
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0076 0.008
Echinococcus multilocularis lamin dm0 0.0054 0.0257 0.0324
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0026 0.0012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0026 0.004
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.1409 0.1408
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.014 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0017 0.0023
Trichomonas vaginalis rotamase, putative 0.0033 0.0118 0.0298
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0264 0.0334
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0139 0.0188
Echinococcus granulosus lamin 0.0054 0.0257 0.0324
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0018 0.0021 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1103 0.1102
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0035 0.0054
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0026 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0139 0.0215
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.014 0.0189
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0095 0.0146
Schistosoma mansoni biogenic amine receptor 0.0036 0.014 0.0139
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0017 0.0026
Echinococcus granulosus nAChR subunit 0.0018 0.0026 0.0012
Echinococcus granulosus lamin dm0 0.0054 0.0257 0.0324
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0051 0.0787
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.014 0.0166
Brugia malayi hypothetical protein 0.0019 0.003 0.0046
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni rotamase 0.0033 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0139 0.0215
Brugia malayi Pre-SET motif family protein 0.006 0.0294 0.0452
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0139 0.0165
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0586 0.3693 0.4963
Onchocerca volvulus Ribonuclease H1 homolog 0.0025 0.0066 0.0089
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0123
Brugia malayi Cation transporter family protein 0.0018 0.0026 0.004
Echinococcus granulosus g protein coupled receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0139 0.0165
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Brugia malayi Dopamine receptor protein 2 0.0036 0.014 0.0216
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0161 1
Schistosoma mansoni lamin 0.0054 0.0257 0.0256
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0139 0.0188
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0256 0.1559 0.1558
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0026 0.0012
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.014 0.0166
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0108 0.0263
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.014 0.0166
Schistosoma mansoni nuclear receptor 0.0017 0.0017 0.0016
Schistosoma mansoni rab6-interacting 0.002 0.0035 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.2549 0.3418
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.1495
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0091 0.01
Schistosoma mansoni adenoreceptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni phosphoglucomutase 0.0025 0.0066 0.0065
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0393 0.0606
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi RE15519p 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0066 0.0803
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0273 0.2474
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0017 0.0016
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.014 0.0166
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0001 0.001
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.014 0.0216
Echinococcus granulosus neuropeptide receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0022 0.0051 0.0068
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.014 0.0139
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0017 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1799 0.1798
Schistosoma mansoni biogenic amine receptor 0.0036 0.014 0.0139
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0031 0.003
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0031 0.0042
Onchocerca volvulus 0.0051 0.024 0.0325
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.003 0.0046
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.024 0.0239
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.015 0.0179
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0091 0.01
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0936
Echinococcus multilocularis serotonin receptor 0.0036 0.014 0.0166
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0161 0.0468
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.014 0.0166
Brugia malayi CXXC zinc finger family protein 0.0029 0.0093 0.0143
Onchocerca volvulus 0.0036 0.014 0.0189
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0326 0.1818
Schistosoma mansoni opsin-like receptor 0.0036 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.0037 0.0149 0.0148
Onchocerca volvulus 0.0104 0.0579 0.0783
Schistosoma mansoni nuclear receptor 0.0017 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi putative neuropeptide receptor 0.0036 0.014 0.0216
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0315 0.0314
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0026 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.014 0.0139
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0031 0.0019
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.014 0.0166
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0064 0.0063
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0171 0.0263
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0077 0.0698
Loa Loa (eye worm) hypothetical protein 0.0054 0.0257 0.0347
Trypanosoma brucei ingi protein (ORF1) 0.003 0.0102 0.0252
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.014 0.0189
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0026 0.004
Schistosoma mansoni sodium/chloride dependent transporter 0.0018 0.0021 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0031 0.003
Echinococcus granulosus tumor protein p63 0.0352 0.2181 0.2921
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0017 0.0026
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0026 0.004
Echinococcus multilocularis orexin receptor type 2 0.0036 0.014 0.0166
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0026 0.004
Schistosoma mansoni slit 0.0024 0.0064 0.0063
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.014 0.0166
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Schistosoma mansoni loxhd1 0.002 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Kringle domain containing protein 0.0022 0.0051 0.0078
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Entamoeba histolytica hypothetical protein 0.0019 0.0031 0.0926
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0064 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Schistosoma mansoni sodium/chloride dependent transporter 0.0104 0.0579 0.0578
Brugia malayi hypothetical protein 0.0019 0.0031 0.0048
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.014 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.014 0.0812 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0139 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.014 0.0166
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0018 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0026 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0139 0.0165
Schistosoma mansoni cpg binding protein 0.0029 0.0093 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1103 0.4362
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0812 0.2681
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Echinococcus granulosus somatostatin receptor 0.0036 0.014 0.0166
Schistosoma mansoni biogenic amine receptor 0.0036 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.0022 0.0051 0.005
Onchocerca volvulus 0.0018 0.0021 0.0029
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0326 0.0441
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0139 0.0165
Echinococcus granulosus voltage dependent calcium channel subunit 0.0266 0.1629 0.2177
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.1103 0.1466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0294 0.0292
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.0783
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0141
Schistosoma mansoni hypothetical protein 0.0257 0.1567 0.1566
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.014 0.0166
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0326 0.2616
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.014 0.0166
Brugia malayi nuclear receptor NHR-88 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0051 0.024 0.0325
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.014 0.0166
Brugia malayi steroid hormone receptor 0.0036 0.0139 0.0215
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0026 0.0012
Brugia malayi larval opioid receptor 0.0036 0.014 0.0216
Schistosoma mansoni ap endonuclease 0.0039 0.0161 0.016
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Brugia malayi hypothetical protein 0.0026 0.0077 0.0119
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Echinococcus granulosus g protein coupled receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0139 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0139 0.0215
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.014 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0139 0.0215
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0026 0.0012
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0026 0.0035
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi tailless protein 0.0017 0.0017 0.0026
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.014 0.0166
Toxoplasma gondii hypothetical protein 0.0018 0.0021 0.0194
Brugia malayi hypothetical protein 0.0019 0.0031 0.0048
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0091 0.01
Echinococcus multilocularis serotonin receptor 0.0036 0.014 0.0166
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0264 0.0334
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.014 0.0812 0.2681
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0139 0.0215
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus granulosus fmrfamide receptor 0.0036 0.014 0.0166
Echinococcus multilocularis allatostatin A receptor 0.0036 0.014 0.0166
Treponema pallidum ribonuclease H (rnhA) 0.0025 0.0066 0.0191
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0031 0.0048
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.0783
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0403 0.2513 0.3399
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.014 0.0139
Toxoplasma gondii exonuclease III APE 0.0039 0.0161 0.1459
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi neuropeptide F receptor 0.0036 0.014 0.0216
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0161 0.1971
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.014 0.0139
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0118 0.107
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0161 0.0218
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0026 0.0035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0017 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.003 0.0029
Brugia malayi neuropeptide F receptor 0.0036 0.014 0.0216
Toxoplasma gondii ribonuclease HI protein 0.0025 0.0066 0.06
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0026 0.0012
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Brugia malayi conserved hypotetical protein 0.0017 0.0017 0.0026
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.014 0.0216
Brugia malayi G protein-coupled receptor 0.0036 0.014 0.0216
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.014 0.0139
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.014 0.0166
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0161 0.0446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0161 0.0663
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.1495
Schistosoma mansoni lipoxygenase 0.002 0.0035 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.0409 0.2549 0.2548
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0139 0.0188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0104 0.0579 0.0578
Schistosoma mansoni ap endonuclease 0.0039 0.0161 0.016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.014 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0149 0.0179
Trichomonas vaginalis rotamase, putative 0.0033 0.0123 0.0316
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0026 0.004
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0035 0.0048
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0035 0.0024
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0021 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0104 0.0579 0.0892
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0294 0.0374
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.014 0.0166
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0139 0.0165
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.014 0.0166
Onchocerca volvulus 0.006 0.0294 0.0397
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0031 0.0019
Schistosoma mansoni coup transcription factor 0.0036 0.0139 0.0138
Onchocerca volvulus 0.002 0.0035 0.0047
Schistosoma mansoni phosphoglucomutase 0.0025 0.0066 0.0065
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1103 0.1102
Brugia malayi nuclear receptor NHR-88 0.0017 0.0017 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0076 0.008
Schistosoma mansoni intermediate filament proteins 0.0054 0.0257 0.0256
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0294 0.2661
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0118 0.0641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0326 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0154 0.3572
Brugia malayi EGF-like domain containing protein 0.0024 0.0064 0.0098
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0031 0.0042
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.014 0.0216
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.014 0.0189
Echinococcus multilocularis cpg binding protein 0.003 0.0103 0.0117
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0077 0.1495
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.003 0.0046
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.1409 0.188
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni hypothetical protein 0.0138 0.0797 0.0796
Echinococcus multilocularis RUN 0.002 0.0035 0.0024
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0118 0.1442
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) doublecortin family protein 0.002 0.0035 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0294 0.0292
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi Serotonin receptor 0.0036 0.014 0.0216
Brugia malayi RNase H family protein 0.0025 0.0066 0.0102
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0051 0.0459
Echinococcus multilocularis neuropeptide receptor 0.0036 0.014 0.0166
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0051 0.0046
Echinococcus granulosus transcription factor Dp 1 0.0037 0.015 0.0179
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0026 0.004
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0026 0.0012
Loa Loa (eye worm) norepinephrine transporter 0.0104 0.0579 0.0783
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0139 0.0165
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0139 0.0188
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.1567 0.2093
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.1103 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0145 0.0842 0.1139
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0026 0.0035
Echinococcus granulosus pikachurin 0.0024 0.0064 0.0063
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.014 0.0166
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0031 0.0019
Onchocerca volvulus 0.1159 0.7394 1
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.014 0.0166
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.1799 0.2406
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni opsin-like receptor 0.0036 0.014 0.0139
Trypanosoma brucei ingi protein (ORF1) 0.003 0.0102 0.0252
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0026 0.0025
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni cpg binding protein 0.003 0.0103 0.0102
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.014 0.0139
Echinococcus granulosus serotonin transporter 0.0104 0.0579 0.0759
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0123 0.019
Echinococcus multilocularis ribonuclease H1 0.0025 0.0066 0.0067
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Schistosoma mansoni neuropeptide receptor 0.0036 0.014 0.0139
Brugia malayi hypothetical protein 0.0122 0.0694 0.1069
Onchocerca volvulus 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.014 0.0166
Brugia malayi Cation transporter family protein 0.0018 0.0026 0.004
Echinococcus multilocularis serotonin transporter 0.0104 0.0579 0.0759
Onchocerca volvulus 0.0036 0.014 0.0189
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0031 0.0048
Brugia malayi follicle stimulating hormone receptor 0.0036 0.014 0.0216
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0021 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.014 0.0139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0139 0.0215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Trichomonas vaginalis ribonuclease H1, putative 0.0025 0.0066 0.012
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0031 0.0019
Echinococcus multilocularis lamin 0.0054 0.0257 0.0324
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.014 0.0166
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0031 0.003
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0542 0.3413 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0026 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Trichomonas vaginalis adenylate cyclase, putative 0.014 0.0812 0.2681
Echinococcus granulosus serotonin receptor 0.0036 0.014 0.0166
Brugia malayi Cache domain containing protein 0.0118 0.067 0.1032
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.1314
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0118 0.3599
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0026 0.0035
Brugia malayi nuclear hormone receptor 0.0036 0.0139 0.0215
Onchocerca volvulus 0.0018 0.0026 0.0035
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0035 0.036
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.1019 0.649 0.8777
Echinococcus multilocularis fmrfamide receptor 0.0036 0.014 0.0166
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0108 0.3281
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0161 0.1971
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0086
Leishmania major ribonuclease H1, putative 0.0025 0.0066 0.0148
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0031 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0123 0.0316
Mycobacterium leprae Possible regulatory protein 0.014 0.0812 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Brugia malayi Serotonin receptor 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0061 0.0549
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0031 0.0042
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0031 0.003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0161 0.0514
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0149 0.0179
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.014 0.0139
Brugia malayi G-protein coupled receptor 0.0036 0.014 0.0216
Plasmodium vivax SET domain protein, putative 0.006 0.0294 0.7316
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0031 0.0048
Brugia malayi PXA domain containing protein 0.0019 0.0031 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0827
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Brugia malayi PXA domain containing protein 0.0019 0.0031 0.0048
Brugia malayi nuclear receptor RXR 0.0019 0.003 0.0046
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0171 0.0479
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0033
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0145 0.0842 0.1114
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis geminin 0.0169 0.1002 0.133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1103 0.4362
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0031 0.0019
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0161 1
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0393 0.3355
Echinococcus granulosus slit 2 protein 0.0024 0.0064 0.0063
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0031 0.0048
Onchocerca volvulus 0.0017 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Treponema pallidum sodium- and chloride- dependent transporter 0.0104 0.0579 0.1693
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.014 0.0189
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0018 0.0021 0.0006
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.014 0.0216
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0018 0.0021 0.0006
Echinococcus multilocularis slit 2 protein 0.0024 0.0064 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0294 0.0374
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0031 0.003
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.014 0.0812 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0018 0.0021 0.002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0017 0.0023
Echinococcus multilocularis expressed protein 0.0373 0.2318 0.3107
Echinococcus multilocularis g protein coupled receptor 0.0036 0.014 0.0166
Brugia malayi laminin alpha chain 0.0024 0.0064 0.0098
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.014 0.0189
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0026 0.0035
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0086
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0064 0.115
Brugia malayi intermediate filament protein 0.0054 0.0257 0.0396
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0139 0.0165
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0048
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0031 0.0019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.014 0.0139
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.014 0.0166
Onchocerca volvulus 0.0018 0.0021 0.0029
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0118 0.0363
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0017 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.2575 0.3483
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Echinococcus multilocularis fmrfamide receptor 0.0036 0.014 0.0166
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Schistosoma mansoni histamine h1 receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0257 0.0347
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.014 0.0166
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0066 0.0803
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0031 0.0019
Onchocerca volvulus 0.0018 0.0026 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0139 0.0215
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni serine-rich repeat protein 0.0138 0.0797 0.0796
Loa Loa (eye worm) hypothetical protein 0.0053 0.0251 0.0339
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0317 0.1956 0.2646
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0827
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0017 0.0016
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0026 0.0012
Onchocerca volvulus 0.0018 0.0021 0.0029
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.1103 0.1466
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0064 0.0098
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0021 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni DNA helicase recq5 0.0028 0.0091 0.009
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0266 0.1629 0.2177
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.014 0.0166
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0031 0.0019
Brugia malayi hypothetical protein 0.0018 0.0021 0.0033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0034
Schistosoma mansoni hypothetical protein 0.0169 0.1002 0.1001
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0326 0.4007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0139 0.0165
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.014 0.0216
Schistosoma mansoni phosphoglucomutase 0.0025 0.0066 0.0065
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0018 0.0021 0.002
Schistosoma mansoni cell polarity protein 0.0024 0.0064 0.0063
Entamoeba histolytica hypothetical protein 0.0019 0.0031 0.0926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0294 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0091 0.0123
Brugia malayi aryl hydrocarbon receptor AHR-1 0.1019 0.649 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.1159 0.7394 1
Brugia malayi Melatonin receptor type 1A 0.0036 0.014 0.0216
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0017 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0094
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0139 0.0215
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0091 0.2646
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0026 0.004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0017 0.0016
Echinococcus multilocularis sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.014 0.0189
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0139 0.0165
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Schistosoma mansoni hypothetical protein 0.0169 0.1002 0.1001
Loa Loa (eye worm) serotonin transporter b 0.0104 0.0579 0.0783
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.014 0.0812 0.2681
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Echinococcus granulosus single minded 2 0.0399 0.2483 0.3329
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Toxoplasma gondii endonuclease IV APN 0.0075 0.0393 0.3567
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0104
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0035 0.0024
Brugia malayi bHLH-PAS transcription factor 0.0399 0.2483 0.3826
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0161 0.492
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0031 0.003
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.0542
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Brugia malayi Dopamine receptor 0.0036 0.014 0.0216
Onchocerca volvulus 0.0018 0.0026 0.0035
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0051 0.0068
Schistosoma mansoni lipoxygenase 0.0055 0.0264 0.0263
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Schistosoma mansoni single-minded 0.0539 0.3388 0.3387
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0139 0.0215
Echinococcus multilocularis nAChR subunit 0.0018 0.0026 0.0012
Leishmania major hypothetical protein, conserved 0.0026 0.0077 0.025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0139 0.0165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0139 0.0138
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Onchocerca volvulus 0.0036 0.014 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0139 0.0188
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.014 0.0139
Schistosoma mansoni myosin xvIII 0.0036 0.014 0.0139
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.1023 0.652 0.8817
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0139 0.0215
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.014 0.0812 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0018 0.0021 0.0006
Echinococcus granulosus hypothetical protein 0.0036 0.014 0.0166
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.014 0.0166
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0139 0.0138
Schistosoma mansoni lamin 0.0054 0.0257 0.0256
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0194
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0139 0.0138
Loa Loa (eye worm) DR-78 0.0017 0.0017 0.0023
Loa Loa (eye worm) RecQ helicase 0.0041 0.0171 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.014 0.0166
Brugia malayi ORL1-like opioid receptor 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Brugia malayi Cation transporter family protein 0.0018 0.0026 0.004
Schistosoma mansoni polycystin 1-related 0.002 0.0035 0.0034
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.014 0.0139
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0171 0.0208
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0123 0.0166
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.014 0.0216
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0091 0.1879
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0194
Onchocerca volvulus 0.0054 0.0257 0.0347
Echinococcus granulosus geminin 0.0169 0.1002 0.133
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0145 0.0842 0.1114
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0326 0.4007
Echinococcus multilocularis g protein coupled receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0149 0.0148
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.1409 0.188
Leishmania major protein kinase, putative 0.014 0.0812 0.7234
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.003 0.0018
Leishmania major protein kinase, putative 0.014 0.0812 0.7234
Echinococcus multilocularis musashi 0.0054 0.0257 0.0324
Echinococcus granulosus RUN 0.002 0.0035 0.0024
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0161 0.0195
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.014 0.0166
Onchocerca volvulus 0.0018 0.0026 0.0035
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0326 0.0417
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0139 0.0188
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.014 0.0812 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0026 0.004
Echinococcus granulosus allatostatin A receptor 0.0036 0.014 0.0166
Brugia malayi PAS domain containing protein 0.0539 0.3388 0.522
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Echinococcus multilocularis transfer RNA-Lys 0.0399 0.2483 0.3329
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.014 0.0812 0.2681
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Brugia malayi hypothetical protein 0.014 0.0812 0.1251
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.014 0.0189
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0031 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0139 0.0165
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0393 0.4612
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.003 0.0018
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0064 0.0063
Echinococcus multilocularis g protein coupled receptor 0.0036 0.014 0.0166
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0021 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0294 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0118 0.1442
Echinococcus multilocularis pikachurin 0.0024 0.0064 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0104 0.0579 0.0783
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0077 0.0076
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0031 0.0042
Trichomonas vaginalis guanylate cyclase, putative 0.014 0.0812 0.2681
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0161 0.0195
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0031 0.0019
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0017 0.0026
Echinococcus granulosus intermediate filament protein 0.0054 0.0257 0.0324
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0161 0.0446
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.003 0.004
Trypanosoma brucei unspecified product 0.003 0.0102 0.0252
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0161 0.1178
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0051 0.0611
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0139 0.0165
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0246 0.1495 0.1494
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0026 0.004
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0812 0.2681
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0257 0.0396
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0026 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0812 0.2681
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0031 0.0019
Onchocerca volvulus 0.0036 0.014 0.0189
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Echinococcus granulosus bloom syndrome protein 0.0041 0.0171 0.0208
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0026 0.0012
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.014 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0139 0.0188
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0017 0.0023
Schistosoma mansoni amine GPCR 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0075 0.0393 0.0532
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0161 0.3752
Brugia malayi ecdysteroid receptor 0.0036 0.0139 0.0215
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0326 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0141
Brugia malayi hypothetical protein 0.0019 0.003 0.0046
Trypanosoma brucei RNA helicase, putative 0.0246 0.1495 1
Onchocerca volvulus 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.014 0.0189
Onchocerca volvulus Putative nachr subunit 0.0018 0.0026 0.0035
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0161 0.1048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Echinococcus granulosus sex peptide receptor 0.0036 0.014 0.0166
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.1567 0.2093
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0393 1
Echinococcus multilocularis sex peptide receptor 0.0036 0.014 0.0166
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0294 0.0374
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.014 0.0166
Brugia malayi sulfakinin receptor protein 0.0036 0.014 0.0216
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0026 0.0012
Brugia malayi hypothetical protein 0.002 0.0035 0.0054
Brugia malayi hypothetical protein 0.0107 0.0598 0.0921
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.014 0.0812 0.7234
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0026 0.0035
Brugia malayi Pre-SET motif family protein 0.0413 0.2575 0.3968
Echinococcus granulosus voltage dependent calcium channel subunit 0.0586 0.3693 0.4963
Loa Loa (eye worm) hypothetical protein 0.014 0.0812 0.1098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0109
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0171 0.0479
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.014 0.0166
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0018 0.0021 0.0033
Chlamydia trachomatis endonuclease IV 0.0075 0.0393 0.4706
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.014 0.0189
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0018 0.0021 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0936
Mycobacterium ulcerans putative regulatory protein 0.0399 0.2483 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Onchocerca volvulus 0.0054 0.0257 0.0347
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.014 0.0166
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0031 0.0019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.014 0.0166
Brugia malayi nuclear hormone receptor 0.0017 0.0017 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0026 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0031 0.0019
Echinococcus granulosus aryl hydrocarbon receptor 0.1163 0.7424 1
Onchocerca volvulus 0.0029 0.0093 0.0126
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.014 0.0139
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.014 0.0812 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0026 0.0025
Brugia malayi hypothetical protein 0.002 0.0035 0.0054
Schistosoma mansoni hypothetical protein 0.0036 0.014 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0161 0.3752
Brugia malayi nuclear receptor RXR 0.0017 0.0017 0.0026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.1103 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0102 0.0252
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0086
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.5144 0.6922
Schistosoma mansoni sodium-dependent amino acid transporter 0.0018 0.0021 0.002
Echinococcus granulosus sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.014 0.0166
Echinococcus granulosus expressed protein 0.0033 0.0123 0.0143
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0031 0.0048
Echinococcus multilocularis tumor protein p63 0.0352 0.2181 0.2921
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0054 0.0074
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0051 0.0787
Onchocerca volvulus 0.0018 0.0026 0.0035
Echinococcus multilocularis somatostatin receptor 0.0036 0.014 0.0166
Schistosoma mansoni opsin-like receptor 0.0036 0.014 0.0139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.006 0.0294 0.0397
Onchocerca volvulus 0.0036 0.0139 0.0188
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0093 0.0126
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0031 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.014 0.0166
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0007 0.0006
Echinococcus granulosus neuropeptide s receptor 0.0036 0.014 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Brugia malayi hypothetical protein 0.0037 0.0149 0.023
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0091 0.01
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0026 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Onchocerca volvulus 0.0017 0.0017 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus neuropeptide receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi Doublecortin family protein 0.002 0.0035 0.0054
Echinococcus multilocularis sodium and chloride dependent glycine 0.0018 0.0021 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0139 0.0188
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0017 0.0026
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0035 0.0024
Brugia malayi GnHR receptor homolog 0.0036 0.014 0.0216
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.003 0.0102 0.0252
Schistosoma mansoni sodium/chloride dependent transporter 0.0018 0.0021 0.002
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.029
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Echinococcus granulosus cpg binding protein 0.003 0.0103 0.0117
Echinococcus multilocularis expressed protein 0.0033 0.0123 0.0143
Onchocerca volvulus 0.0036 0.014 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0029
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0026 0.0012
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0018 0.0021 0.0194
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0077 0.0076
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.4566
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.004
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.014 0.0166
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0064 0.0063
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0026 0.0012
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.014 0.0812 0.2681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0139 0.0188
Brugia malayi RNase H family protein 0.0025 0.0066 0.0102
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0026 0.0012
Onchocerca volvulus 0.0018 0.0026 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0017 0.0026
Brugia malayi G-protein coupled receptor 0.0036 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Echinococcus granulosus ribonuclease H1 0.0025 0.0066 0.0067
Schistosoma mansoni nAChR subunit 0.0018 0.0026 0.0025
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0326 0.0417
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0129 0.074 0.0739
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0026 0.0012
Mycobacterium ulcerans endonuclease IV 0.0075 0.0393 0.1463
Loa Loa (eye worm) hypothetical protein 0.0118 0.067 0.0906
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni thyroid hormone receptor 0.0293 0.1799 0.1798
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.1409 0.1906
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0095 0.0128
Brugia malayi ecdysone receptor 0.0017 0.0017 0.0026
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.014 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0139 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0139 0.0165
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0064 0.0086
Brugia malayi Dopamine receptor protein 1 0.0036 0.014 0.0216
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0139 0.0138
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0035 0.0024
Onchocerca volvulus 0.002 0.0035 0.0047
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0018 0.0021 0.0006
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0026 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0161 0.0248
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.014 0.0166
Onchocerca volvulus 0.047 0.2943 0.398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0139 0.0215
Schistosoma mansoni rab6-interacting 0.002 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.014 0.0216
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0023
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0139 0.0188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1103 0.4362
Echinococcus multilocularis neuropeptide receptor 0.0036 0.014 0.0166
Brugia malayi Protein kinase domain containing protein 0.0022 0.0051 0.0078
Echinococcus multilocularis aryl hydrocarbon receptor 0.1163 0.7424 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.014 0.0812 0.2681
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0064 0.0098
Brugia malayi hypothetical protein 0.0036 0.014 0.0216
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.014 0.0139
Schistosoma mansoni cpg binding protein 0.003 0.0103 0.0102
Loa Loa (eye worm) solute carrier family 6 member 4 0.0104 0.0579 0.0783
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0026 0.0025
Schistosoma mansoni zinc finger protein 0.0017 0.0017 0.0016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0326 0.0502
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0188
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.014 0.0166
Brugia malayi RNase H family protein 0.0025 0.0066 0.0102
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.014 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0031 0.003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0139 0.0165
Brugia malayi AKH receptor 0.0036 0.014 0.0216
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0026 0.0025
Echinococcus granulosus dnaJ subfamily B 0.0409 0.2549 0.3418
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0393 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0017 0.0026
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.1103 1
Echinococcus granulosus g protein coupled receptor 0.0036 0.014 0.0166
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0026 0.0012
Trichomonas vaginalis set domain proteins, putative 0.047 0.2943 1
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.014 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.014 0.0139
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0031 0.003

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 5.8 Antagonistic activity against alpha-1 adrenergic receptor in isolated rat anococcygeus muscle ChEMBL. 2838634
Kd (functional) = 7.1 Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens ChEMBL. 2838634
pA2 (functional) = 5.8 Antagonistic activity against alpha-1 adrenergic receptor in isolated rat anococcygeus muscle ChEMBL. 2838634
pA2 (functional) = 7.1 Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens ChEMBL. 2838634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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