Detailed information for compound 428303

Basic information

Technical information
  • TDR Targets ID: 428303
  • Name: 4-[[7-(5-cyano-2-methylphenyl)-5-methyl-1,2,4 -benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-y lethyl)benzenesulfonamide
  • MW: 527.641 | Formula: C28H29N7O2S
  • H donors: 2 H acceptors: 6 LogP: 4.06 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc(c(c1)c1cc(C)c2c(c1)nnc(n2)Nc1ccc(cc1)S(=O)(=O)NCCN1CCCC1)C
  • InChi: 1S/C28H29N7O2S/c1-19-5-6-21(18-29)16-25(19)22-15-20(2)27-26(17-22)33-34-28(32-27)31-23-7-9-24(10-8-23)38(36,37)30-11-14-35-12-3-4-13-35/h5-10,15-17,30H,3-4,11-14H2,1-2H3,(H,31,32,34)
  • InChiKey: DKRTWRRBVFCPKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[7-(5-cyano-2-methyl-phenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide
  • 4-[[7-(5-cyano-2-methylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-[2-(1-pyrrolidinyl)ethyl]benzenesulfonamide
  • 4-[[7-(5-cyano-2-methyl-phenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidinoethyl)benzenesulfonamide
  • 4-[[7-(5-cyano-2-methylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-1-pyrrolidinylethyl)benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Echinococcus granulosus cyclins 0.0011 0.035 0.0458
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 2, putative 0.0005 0.0022 0.0034
Trypanosoma brucei calpain, putative 0.0063 0.2941 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.2462 0.3135
Plasmodium vivax DNA repair protein REV1, putative 0.0009 0.0238 0.1013
Brugia malayi Protein kinase domain containing protein 0.0006 0.0064 0.0064
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0134 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Echinococcus granulosus protein quaking 0.0015 0.0542 0.071
Leishmania major DNA damage repair protein, putative 0.0009 0.0238 0.0759
Trichomonas vaginalis ral, putative 0.0036 0.1561 0.6306
Onchocerca volvulus 0.0006 0.0064 0.0064
Echinococcus granulosus transcription factor Dp 1 0.0022 0.0854 0.1119
Schistosoma mansoni tyrosine kinase 0.001 0.0287 0.0366
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0037 0.1641 0.5546
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0451 0.1758
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0016 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0075
Echinococcus multilocularis flap endonuclease 1 0.0015 0.0509 0.0648
Loa Loa (eye worm) AGC/PKG protein kinase 0.0005 0.0016 0.0016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0005 0.0022 0.0028
Toxoplasma gondii ubiquitin-specific protease USP4 0.0005 0.0022 0.0031
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0005 0.0022 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0005 0.0022 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0037 0.1641 0.5546
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0005 0.0022 0.0028
Schistosoma mansoni hypothetical protein 0.0006 0.0091 0.0116
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.013 0.0166
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.206 0.2701
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0063 0.2941 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0005 0.0022 0.0029
Trichomonas vaginalis cyclin D, putative 0.0011 0.035 0.1341
Trichomonas vaginalis cyclin B, putative 0.0011 0.035 0.1341
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Schistosoma mansoni tyrosine kinase 0.0045 0.206 0.2623
Trichomonas vaginalis cyclin D, putative 0.0011 0.035 0.1341
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.1918 0.7791
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0063 0.2941 1
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0016 0.002
Entamoeba histolytica protein kinase, putative 0.0005 0.0024 0.0096
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0034 0.1462 0.4942
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0223 0.0223
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.2028 0.6871
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0009 0.0219 0.0278
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0052 0.0052
Entamoeba histolytica cyclin family protein 0.0011 0.035 0.142
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.1996 0.6762
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Echinococcus granulosus son of sevenless 1 0.0007 0.013 0.017
Onchocerca volvulus 0.001 0.0275 0.0275
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0238 0.0738
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0005 0.0022 0.0029
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0009 0.0219 0.0673
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.7855 0.7855
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0005 0.0022 0.0028
Loa Loa (eye worm) tumor suppressor 0.0181 0.8882 0.8882
Echinococcus granulosus bloom syndrome protein 0.0014 0.0451 0.0592
Schistosoma mansoni ras GTP exchange factor 0.0007 0.013 0.0166
Brugia malayi hypothetical protein 0.0006 0.0064 0.0064
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.1918 0.2442
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.2084 0.2732
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.195 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0275 0.0275
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0009 0.0219 0.0673
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.013 0.0166
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.013 0.0166
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0053 0.2462 0.3135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0052 0.017
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0005 0.0022 0.0034
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.013 0.0441
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.2148 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0037 0.1641 0.5546
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.2028 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Loa Loa (eye worm) hypothetical protein 0.0036 0.1561 0.1561
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0005 0.0022 0.0028
Onchocerca volvulus 0.0005 0.0022 0.0022
Loa Loa (eye worm) isocitrate dehydrogenase 0.0009 0.0219 0.0219
Onchocerca volvulus 0.0005 0.0022 0.0022
Trichomonas vaginalis rheb, putative 0.0036 0.1561 0.6306
Schistosoma mansoni nck2/grb4 0.0009 0.0223 0.0284
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0005 0.0022 0.0028
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0275 0.035
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Entamoeba histolytica Ras family GTPase 0.0036 0.1561 0.634
Onchocerca volvulus 0.0006 0.0064 0.0064
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0005 0.0022 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.2028 0.6871
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.013 0.013
Loa Loa (eye worm) acetyltransferase 0.0161 0.7855 0.7855
Echinococcus granulosus cyclins 0.0011 0.035 0.0458
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0231 0.0981
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.013 0.0166
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0113 0.0143
Loa Loa (eye worm) hypothetical protein 0.0014 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.1773 0.2324
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0095 0.4572 0.582
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0052 0.017
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Trypanosoma brucei PAB1-binding protein , putative 0.0014 0.0485 0.1586
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0485 0.1586
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.1111 0.4461
Trichomonas vaginalis ras-dva small GTPase, putative 0.0036 0.1561 0.6306
Entamoeba histolytica cyclin, putative 0.0011 0.035 0.142
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.1275 0.1275
Schistosoma mansoni DNA polymerase eta 0.0044 0.1996 0.2541
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0005 0.0022 0.0028
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0005 0.0022 0.0028
Echinococcus granulosus cyclin b3 0.0011 0.035 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Loa Loa (eye worm) TK protein kinase 0.0036 0.1608 0.1608
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0287 0.0366
Loa Loa (eye worm) hypothetical protein 0.0043 0.1918 0.1918
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.1918 0.7771
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0005 0.0022 0.0029
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0287 0.0366
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Echinococcus granulosus dna polymerase kappa 0.0045 0.2028 0.2659
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0063 0.2941 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.206 0.2623
Brugia malayi Cyclin, N-terminal domain containing protein 0.0011 0.035 0.035
Trypanosoma cruzi DNA damage repair protein, putative 0.0009 0.0238 0.0738
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Echinococcus granulosus geminin 0.0095 0.4572 0.5993
Schistosoma mansoni dep domain containing protein 0.001 0.0275 0.035
Echinococcus granulosus cyclins 0.0011 0.035 0.0458
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0005 0.0022 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0037 0.1641 0.2089
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0034 0.1462 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0134 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.1918 0.7771
Trypanosoma cruzi cyclin 6, putative 0.0011 0.035 0.1121
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.1918 0.2515
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0959 0.321
Leishmania major DNA polymerase kappa, putative 0.0009 0.0238 0.0759
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0275 0.035
Brugia malayi serine/threonine-protein kinase plk-2 0.0053 0.2462 0.2462
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.206 0.2701
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Entamoeba histolytica ras-1, putative 0.0036 0.1561 0.634
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.013 0.017
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.7628 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.206 0.2623
Echinococcus granulosus dna polymerase eta 0.0044 0.1996 0.2617
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0053 0.2462 0.8362
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.1837 0.2339
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0009 0.0219 0.0278
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0275 0.0275
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.1918 0.2442
Brugia malayi ubiquitin specific protease 14 0.0005 0.0022 0.0022
Plasmodium falciparum ubiquitin specific protease, putative 0.0005 0.0022 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0485 0.2427
Trichomonas vaginalis cyclin B3, putative 0.0011 0.035 0.1341
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0015 0.0509 0.1667
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.1275 0.1275
Loa Loa (eye worm) TK/ABL protein kinase 0.0006 0.0064 0.0064
Trichomonas vaginalis cyclin A, putative 0.0011 0.035 0.1341
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.1918 0.2515
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.1275 0.1623
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Trichomonas vaginalis rap1 and, putative 0.0036 0.1561 0.6306
Schistosoma mansoni flap endonuclease-1 0.0013 0.0438 0.0558
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0223 0.0284
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0052 0.0052
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0275 0.036
Trichomonas vaginalis GTP-binding protein rit, putative 0.0036 0.1561 0.6306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Echinococcus granulosus cyclins 0.0011 0.035 0.0458
Echinococcus multilocularis protein quaking 0.0015 0.0542 0.069
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0053 0.2462 0.8358
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.2028 0.822
Trichomonas vaginalis cyclin B, putative 0.0011 0.035 0.1341
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0425 0.1918
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0995 0.3332
Echinococcus granulosus tyrosine kinase 0.0006 0.0064 0.0084
Schistosoma mansoni calpain-7 (C02 family) 0.0005 0.0022 0.0028
Echinococcus granulosus tyrosine kinase 0.0041 0.1837 0.2408
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Echinococcus granulosus hypothetical protein 0.0015 0.0542 0.071
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0005 0.0022 0.0028
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0275 0.035
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0006 0.0064 0.0261
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.7855 1
Schistosoma mansoni hypothetical protein 0.0015 0.0542 0.069
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0016 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Giardia lamblia DNA damage repair protein 0.0009 0.0238 0.0883
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0005 0.0022 0.0028
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0223 0.0223
Echinococcus granulosus ubiquitin specific peptidase c family 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0203 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.0006 0.0064 0.0084
Loa Loa (eye worm) SRC-1 0.0045 0.206 0.206
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.1111 0.4461
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Trypanosoma cruzi DNA damage repair protein, putative 0.0009 0.0238 0.0738
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0037 0.1641 0.1641
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0009 0.0219 0.0287
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0451 0.0451
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0275 0.0275
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.1918 0.7771
Loa Loa (eye worm) hypothetical protein 0.0011 0.035 0.035
Trypanosoma cruzi cyclin, putative 0.0011 0.035 0.1121
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0063 0.2941 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.013 0.013
Schistosoma mansoni regulator of G protein signaling 0.001 0.0275 0.035
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0053 0.2462 0.2462
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0005 0.0022 0.0028
Brugia malayi Flap endonuclease-1 0.0015 0.0509 0.0509
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0005 0.0022 0.0028
Brugia malayi Protein kinase domain containing protein 0.0006 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0064 0.0064
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.1918 0.6503
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.206 0.2701
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.1918 0.2442
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0238 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0005 0.0022 0.0028
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0005 0.0022 0.0029
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0005 0.0022 0.0034
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Echinococcus multilocularis isocitrate dehydrogenase 0.0009 0.0219 0.0278
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0009 0.0219 0.105
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0005 0.0022 0.0029
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0005 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0542 0.0542
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Trichomonas vaginalis cyclins, putative 0.0011 0.035 0.1341
Brugia malayi hypothetical protein 0.0015 0.0542 0.0542
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0005 0.0022 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0005 0.0022 0.0028
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0005 0.0022 0.0028
Trichomonas vaginalis cyclins, putative 0.0011 0.035 0.1341
Giardia lamblia Cyclin A 0.0011 0.035 0.1341
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0009 0.0219 0.0278
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0223 0.0223
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Schistosoma mansoni dishevelled 0.001 0.0275 0.035
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0223 0.0293
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0223 0.0223
Trypanosoma brucei polo-like protein kinase 0.0053 0.2462 0.8358
Echinococcus granulosus cyclin B3 1 0.0011 0.035 0.0458
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0005 0.0022 0.0028
Entamoeba histolytica hypothetical protein 0.0007 0.013 0.0528
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0011 0.035 0.0445
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.1918 0.2442
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0063 0.2941 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0275 0.0275
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0009 0.0219 0.0694
Loa Loa (eye worm) hypothetical protein 0.001 0.0275 0.0275
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0308 0.0392
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0005 0.0022 0.0029
Onchocerca volvulus 0.0005 0.0022 0.0022
Leishmania major DNA polymerase eta, putative 0.0044 0.1996 0.677
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.1918 0.2515
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0223 0.0284
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 1 1
Schistosoma mansoni tyrosine kinase 0.0045 0.206 0.2623
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0005 0.0022 0.0028
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.013 0.0166
Onchocerca volvulus 0.0006 0.0064 0.0064
Trichomonas vaginalis cyclin B, putative 0.0011 0.035 0.1341
Plasmodium falciparum cyclin 0.0011 0.035 0.1726
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.1275 0.8496
Schistosoma mansoni adapter molecule crk 0.0009 0.0223 0.0284
Entamoeba histolytica Flap nuclease, putative 0.0015 0.0509 0.2067
Loa Loa (eye worm) hypothetical protein 0.0068 0.3195 0.3195
Loa Loa (eye worm) RecQ helicase 0.0014 0.0451 0.0451
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.013 0.013
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Loa Loa (eye worm) cyclin domain-containing protein 0.0011 0.035 0.035
Schistosoma mansoni peptidase 0.0005 0.0046 0.0059
Trichomonas vaginalis DNA helicase recq, putative 0.0007 0.0134 0.046
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0009 0.0219 0.0673
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0275 0.0275
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0053 0.2462 0.3228
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0037 0.1641 0.2089
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0037 0.1641 0.6666
Echinococcus granulosus cyclins 0.0011 0.035 0.0458
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.2148 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0037 0.1641 0.2152
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Echinococcus granulosus flap endonuclease 1 0.0015 0.0509 0.0667
Echinococcus multilocularis dna polymerase kappa 0.0045 0.2028 0.2582
Schistosoma mansoni DNA polymerase IV / kappa 0.0009 0.0238 0.0303
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0005 0.0022 0.0022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0005 0.0022 0.0029
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Trypanosoma brucei mitotic cyclin 6 0.0011 0.035 0.1121
Echinococcus multilocularis cyclin B3 1 0.0011 0.035 0.0445
Trichomonas vaginalis dexras1, putative 0.0036 0.1561 0.6306
Schistosoma mansoni tyrosine kinase 0.0006 0.0064 0.0082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Brugia malayi SRC-1 0.0045 0.206 0.206
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.206 0.2701
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.1837 0.2408
Onchocerca volvulus 0.0007 0.013 0.013
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0005 0.0022 0.0034
Trypanosoma cruzi cyclin, putative 0.0011 0.035 0.1121
Entamoeba histolytica cyclin, putative 0.0011 0.035 0.142
Trypanosoma brucei hypothetical protein 0.0063 0.2941 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.1918 0.1918
Plasmodium falciparum flap endonuclease 1 0.0015 0.0509 0.2549
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0005 0.0022 0.0029
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0006 0.0091 0.012
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0015 0.0509 0.1667
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.1773 0.2257
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Brugia malayi Cyclin, N-terminal domain containing protein 0.0011 0.035 0.035
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Trypanosoma brucei calpain-like protein, putative 0.0063 0.2941 1
Entamoeba histolytica hypothetical protein 0.0005 0.0022 0.0091
Onchocerca volvulus Serine\/threonine kinase homolog 0.0053 0.2462 0.2462
Trypanosoma brucei DNA damage repair protein, putative 0.0009 0.0238 0.0738
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0005 0.0022 0.0029
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0005 0.0022 0.0028
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0275 0.036
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.1608 0.2108
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.1275 0.1671
Onchocerca volvulus 0.0011 0.035 0.035
Brugia malayi hypothetical protein 0.001 0.0275 0.0275
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.001 0.0275 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0016 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0016 0.002
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0223 0.0284
Toxoplasma gondii hypothetical protein 0.0009 0.021 0.0911
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0451 0.1758
Loa Loa (eye worm) hypothetical protein 0.0011 0.035 0.035
Echinococcus granulosus Protein son of sevenless 0.0007 0.013 0.017
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0016 0.002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.013 0.0166
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0005 0.0022 0.0028
Echinococcus multilocularis geminin 0.0095 0.4572 0.582
Brugia malayi hypothetical protein 0.001 0.0275 0.0275
Trypanosoma brucei unspecified product 0.0041 0.1841 0.6231
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0238 0.0738
Echinococcus granulosus ras GTP exchange factor 0.0007 0.013 0.017
Brugia malayi Ras-related protein R-Ras2 0.0036 0.1561 0.1561
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Trichomonas vaginalis cyclin B, putative 0.0011 0.035 0.1341
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Brugia malayi N-terminal motif family protein 0.0007 0.013 0.013
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0005 0.0022 0.0028
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.206 0.2623
Brugia malayi isocitrate dehydrogenase 0.0009 0.0219 0.0219
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0223 0.0223
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0287 0.0377
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0238 0.0738
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0009 0.0238 0.1041
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0005 0.0022 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0005 0.0022 0.0028
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0005 0.0022 0.0029
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.013 0.017
Trichomonas vaginalis cyclins, putative 0.0011 0.035 0.1341
Entamoeba histolytica protein kinase, putative 0.0036 0.1608 0.6531
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0005 0.0022 0.0028
Entamoeba histolytica Ras family GTPase 0.0036 0.1561 0.634
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0063 0.2941 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0959 0.4425
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.206 0.2701
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.1918 0.6495
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Echinococcus multilocularis son of sevenless 1 0.0007 0.013 0.0166
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0287 0.0366
Brugia malayi RasGEF domain containing protein 0.0007 0.013 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0995 0.3332
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0005 0.0022 0.0028
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0287 0.0287
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0005 0.0024 0.0096
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0011 0.035 0.1141
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.1918 0.2442
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.013 0.0441
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0005 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0275 0.036
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.1275 0.1623
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Brugia malayi RasGEF domain containing protein 0.0007 0.013 0.013
Onchocerca volvulus 0.0006 0.0064 0.0064
Brugia malayi Ras protein let-60 0.0036 0.1561 0.1561
Echinococcus multilocularis ras gtpase 0.0036 0.1561 0.1987
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0275 0.035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Schistosoma mansoni dishevelled 0.001 0.0275 0.035
Echinococcus multilocularis Protein son of sevenless 0.0007 0.013 0.0166
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0015 0.0509 0.1686
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0012 0.0369 0.1824
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0223 0.0284
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0005 0.0022 0.0091
Toxoplasma gondii hypothetical protein 0.0005 0.0022 0.0031
Brugia malayi Cyclin, N-terminal domain containing protein 0.0011 0.035 0.035
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0006 0.0064 0.0084
Echinococcus multilocularis cyclin b3 0.0011 0.035 0.0445
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Toxoplasma gondii hypothetical protein 0.001 0.0275 0.1214
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.1608 0.2047
Echinococcus multilocularis transcription factor Dp 1 0.0022 0.0854 0.1087
Leishmania major DNA polymerase eta, putative 0.0024 0.0959 0.3226
Schistosoma mansoni DNA helicase recq1 0.0006 0.0052 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0009 0.0219 0.0673
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Schistosoma mansoni cyclins 0.0011 0.035 0.0445
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0134 0.0406
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.013 0.0441
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Trypanosoma cruzi hypothetical protein 0.0007 0.013 0.0369
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.195 0.7921
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0005 0.0022 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.1996 0.1996
Leishmania major hypothetical protein, conserved 0.0014 0.0485 0.1605
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.195 0.7902
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0005 0.0022 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0005 0.0022 0.0031
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Onchocerca volvulus 0.0006 0.0064 0.0064
Trichomonas vaginalis cyclin B, putative 0.0011 0.035 0.1341
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.2148 0.8714
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0009 0.0238 0.1148
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.1918 0.6495
Schistosoma mansoni cyclin B3 0.0011 0.035 0.0445
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0005 0.0022 0.0028
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0006 0.0052 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0275 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.2148 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.013 0.0166
Brugia malayi Isocitrate dehydrogenase 0.0009 0.0219 0.0219
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.206 0.2623
Onchocerca volvulus 0.0006 0.0064 0.0064
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Brugia malayi hypothetical protein 0.0014 0.0485 0.0485
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Giardia lamblia G2/mitotic-specific cyclin B 0.0011 0.035 0.1341
Brugia malayi hypothetical protein 0.0009 0.0232 0.0232
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0005 0.0022 0.0031
Echinococcus granulosus NCK adaptor protein 0.0009 0.0223 0.0293
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Trypanosoma brucei unspecified product 0.0021 0.0808 0.2692
Giardia lamblia Sgs1 DNA helicase, putative 0.0006 0.0052 0.0121
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.206 0.2623
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.1275 0.1623
Brugia malayi hypothetical protein 0.0005 0.0022 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0006 0.0064 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0063 0.2941 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0006 0.0064 0.0082
Toxoplasma gondii isocitrate dehydrogenase 0.0009 0.0219 0.0952
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0009 0.0219 0.0924
Trypanosoma cruzi hypothetical protein 0.0007 0.013 0.0369
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.1275 0.5177
Schistosoma mansoni kinase 0.0027 0.1146 0.1459
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Echinococcus granulosus c src tyrosine kinase 0.001 0.0287 0.0377
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.013 0.013
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0485 0.1586
Brugia malayi Protein kinase domain containing protein 0.0006 0.0064 0.0064
Echinococcus granulosus tyrosine protein kinase Srms 0.0006 0.0064 0.0084
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0006 0.0064 0.0082
Echinococcus multilocularis expressed conserved protein 0.0005 0.0016 0.002
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0005 0.0022 0.0028
Giardia lamblia DINP protein human, muc B family 0.0034 0.1462 0.5899
Schistosoma mansoni hypothetical protein 0.0015 0.0542 0.069
Trypanosoma cruzi CYC2-like cyclin, putative 0.0011 0.035 0.1121
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0005 0.0022 0.0029
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0451 0.0574
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0275 0.035
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0005 0.0022 0.0028
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.206 0.2623
Leishmania major DNA polymerase kappa, putative 0.0034 0.1462 0.4942
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0063 0.2941 1
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0223 0.0284
Brugia malayi SH2 domain containing protein 0.0006 0.0064 0.0064
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0991 0.3319
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0006 0.0052 0.0068
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0037 0.1641 0.5556
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.206 0.2701
Echinococcus granulosus cyclin B 0.0011 0.035 0.0458
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0995 0.3332
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0275 0.036
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.035 0.1341
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.1996 0.1996
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Schistosoma mansoni DNA helicase recq5 0.0006 0.0052 0.0066
Toxoplasma gondii isocitrate dehydrogenase 0.0009 0.0219 0.0952
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.1841 0.6231
Entamoeba histolytica cyclin family protein 0.0011 0.035 0.142
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0006 0.0052 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Schistosoma mansoni tyrosine kinase 0.001 0.0287 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0005 0.0022 0.0028
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0005 0.0022 0.0028
Entamoeba histolytica recQ family helicase, putative 0.0007 0.0134 0.0546
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0022
Echinococcus multilocularis cyclins 0.0011 0.035 0.0445
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0005 0.0022 0.0029
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.013 0.0441
Brugia malayi Temporarily assigned gene name protein 44 0.0015 0.0542 0.0542
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Onchocerca volvulus 0.0005 0.0018 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.2462 1
Giardia lamblia Flap structure-specific endonuclease 0.0015 0.0509 0.1994
Echinococcus granulosus ras gtpase 0.0036 0.1561 0.2046
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.1918 0.7771
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0226 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0991 0.3319
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0005 0.0022 0.0028
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.1837 0.2408
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.0485 0.2177
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Brugia malayi protein-tyrosine kinase 0.0041 0.1837 0.1837
Brugia malayi Egg laying defective protein 4 0.0005 0.0016 0.0016
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0011 0.035 0.0458
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0005 0.0022 0.0028
Plasmodium vivax flap endonuclease 1, putative 0.0015 0.0509 0.2289
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.1996 0.6762
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0006 0.0052 0.0068
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.1837 0.2339
Echinococcus multilocularis cyclin B 0.0011 0.035 0.0445
Schistosoma mansoni hypothetical protein 0.0095 0.4572 0.582
Brugia malayi RasGEF domain containing protein 0.0007 0.013 0.013
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0275 0.035
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.2028 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0005 0.0022 0.0091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0006 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0006 0.0052 0.0052
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0037 0.1641 0.1641
Brugia malayi SH2 domain containing protein 0.0006 0.0064 0.0064
Brugia malayi DIX domain containing protein 0.001 0.0275 0.0275
Echinococcus granulosus tyrosine protein kinase ABL1 0.0006 0.0064 0.0084
Loa Loa (eye worm) hypothetical protein 0.0007 0.013 0.013
Brugia malayi Protein kinase domain containing protein 0.0006 0.0064 0.0064
Trichomonas vaginalis flap endonuclease-1, putative 0.0015 0.0509 0.1994
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.2028 0.822
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Trypanosoma brucei chrX additional, unordered contigs 0.0009 0.0238 0.0738
Loa Loa (eye worm) hypothetical protein 0.0007 0.013 0.013
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0005 0.0022 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Trypanosoma brucei DNA damage repair protein, putative 0.0009 0.0238 0.0738
Loa Loa (eye worm) flap endonuclease-1 0.0015 0.0509 0.0509
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0275 0.035
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0006 0.0052 0.0187
Echinococcus multilocularis expressed protein 0.0005 0.0022 0.0028
Echinococcus multilocularis tyrosine kinase 0.0006 0.0064 0.0082
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0006 0.0052 0.0052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.206 0.2623
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.013 0.0369
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0005 0.0022 0.0028
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.206 0.2623
Trichomonas vaginalis cyclins, putative 0.0011 0.035 0.1341
Echinococcus granulosus cGMP dependent protein kinase 0.0005 0.0016 0.0021
Entamoeba histolytica serine/threonine protein kinase, putative 0.0053 0.2462 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0015 0.0509 0.2313
Brugia malayi tumor suppressor. 0.0181 0.8882 0.8882
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0485 0.2427
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0275 0.036
Leishmania major cyclin 0.0011 0.035 0.1141
Giardia lamblia Kinase, PLK 0.0053 0.2462 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0053 0.2462 0.8358
Giardia lamblia Hypothetical protein 0.0011 0.035 0.1341
Echinococcus multilocularis dna polymerase eta 0.0044 0.1996 0.2541
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0064 0.0064
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0287 0.0366
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0005 0.0022 0.0029
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.1837 0.2339
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0009 0.0219 0.0278
Loa Loa (eye worm) hypothetical protein 0.0024 0.0991 0.0991
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.2148 0.8714
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.2148 0.2816
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.1918 0.6495
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0005 0.0022 0.0029
Brugia malayi Protein kinase domain containing protein 0.0006 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0005 0.0022 0.0028
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0005 0.0022 0.0091
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0005 0.0022 0.0028
Loa Loa (eye worm) Ras protein let-60 0.0036 0.1561 0.1561
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.206 0.2623
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.013 0.0528
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0005 0.0022 0.0023
Loa Loa (eye worm) TK protein kinase 0.0041 0.1837 0.1837
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0005 0.0022 0.0031
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0016 0.0021
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0005 0.0022 0.0022
Schistosoma mansoni calpain-7 (C02 family) 0.0005 0.0022 0.0028
Trypanosoma brucei unspecified product 0.0021 0.0808 0.2692
Brugia malayi polk-prov protein 0.0024 0.0991 0.0991
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.2028 0.6871
Schistosoma mansoni tyrosine kinase 0.0006 0.0064 0.0082
Schistosoma mansoni cyclin B 0.0011 0.035 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.1462 0.493
Trichomonas vaginalis cyclins, putative 0.0011 0.035 0.1341
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0005 0.0022 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0005 0.0022 0.0029
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0005 0.0022 0.0034
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.0005 0.0022 0.0034
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.206 0.2701
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0005 0.0022 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.0485 0.2202
Brugia malayi N-terminal motif family protein 0.0007 0.013 0.013
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0005 0.0022 0.0028
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.7855 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0009 0.0219 0.0278
Plasmodium falciparum ubiquitin specific protease, putative 0.0005 0.0022 0.0034
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0275 0.0275

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 25.2 nM Luciferase-Based Assay BINDINGDB. No reference
IC50 (binding) = 25.2 nM Inhibition of human recombinant c-Src using PTK2 substrate incubated for 90 mins by luciferase-based assay PATENT. No reference
IC50 (binding) = 0.025 uM Inhibition of Src ChEMBL. 17113292
IC50 (binding) = 0.025 uM Inhibition of Src ChEMBL. 17113292

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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