Detailed information for compound 432952

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.51 | Formula: C20H36N2O6
  • H donors: 3 H acceptors: 5 LogP: 4.05 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCC(=O)C(=O)N[C@@H](COC(=O)NCC)CCC(=O)O
  • InChi: 1S/C20H36N2O6/c1-3-5-6-7-8-9-10-11-12-17(23)19(26)22-16(13-14-18(24)25)15-28-20(27)21-4-2/h16H,3-15H2,1-2H3,(H,21,27)(H,22,26)(H,24,25)/t16-/m1/s1
  • InChiKey: WFTHLWOMRNLLCR-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0359
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0044 0.0101 0.144
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0086 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0359
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0229 0.0665 0.1901
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.003 0.0816
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.144
Leishmania major phosphatidylinositol 3-kinase, putative 0.0229 0.0665 0.183
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0066 0.0253
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0132 0.0349
Brugia malayi Doublecortin family protein 0.002 0.0027 0.0322
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0033 0.0066 0.0011
Trypanosoma cruzi hypothetical protein 0.0093 0.0252 0.0709
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0044 0.0101 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0359
Brugia malayi beta-lactamase 0.0032 0.0065 0.0776
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0027 0.0027
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.017 0.0487 0.578
Loa Loa (eye worm) Ulp1 protease 0.0039 0.0086 0.102
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0027 0.0027
Loa Loa (eye worm) oxidoreductase 0.0033 0.0066 0.0784
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0129 0.036 0.1022
Echinococcus multilocularis expressed conserved protein 0.0136 0.0383 0.0383
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0072 0.0116
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0101 0.0101
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0083 0.022 0.6431
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0132 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Schistosoma mansoni tar DNA-binding protein 0.0287 0.0843 0.3044
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.022 0.2615
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0445 0.0445
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0176 0.0503 0.1818
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0306 1
Plasmodium vivax sentrin-specific protease 1, putative 0.0039 0.0086 0.3041
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0101 0.1194
Schistosoma mansoni alpha-glucosidase 0.0135 0.0378 0.1366
Schistosoma mansoni microtubule-associated protein tau 0.0917 0.2769 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0229 0.0665 0.183
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0306 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0081 0.1136
Onchocerca volvulus 0.002 0.0027 0.0714
Schistosoma mansoni rab6-interacting 0.002 0.0027 0.0098
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0093 0.0252 0.0909
Entamoeba histolytica acyl-coA synthetase, putative 0.0111 0.0306 0.4561
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0072 0.1011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0045 0.0538
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0957
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0101 0.144
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0072 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.003 0.0359
Schistosoma mansoni lipoxygenase 0.002 0.0027 0.0098
Mycobacterium tuberculosis Conserved protein 0.0032 0.0065 0.0241
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0044 0.0101 0.38
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0044 0.0101 0.0363
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0207 0.06 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.144
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Loa Loa (eye worm) beta-lactamase 0.0032 0.0065 0.0776
Loa Loa (eye worm) phosphatidylinositol 3 0.0229 0.0665 0.7892
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0359
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0081 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0101 0.38
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.0473 0.7085
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Loa Loa (eye worm) hypothetical protein 0.0083 0.022 0.2615
Giardia lamblia Hypothetical protein 0.0044 0.0101 0.0342
Loa Loa (eye worm) doublecortin family protein 0.002 0.0027 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0072 0.0192
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0033 0.0066 0.0028
Toxoplasma gondii propionate-CoA ligase 0.0033 0.0066 0.0011
Leishmania major hypothetical protein, unknown function 0.0044 0.0101 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0072 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0359
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0129 0.036 0.036
Onchocerca volvulus 0.0039 0.0086 0.2668
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.003 0.0359
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.01 0.0271 0.0271
Toxoplasma gondii target of rapamycin (TOR), putative 0.0229 0.0665 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0065 0.0065
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0111 0.0306 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.102
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.003 0.0109
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2468 0.7512 0.7512
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0044 0.0101 0.144
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0306 0.3636
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0359
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0101 0.0587
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0081 0.0291
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0132 0.1103
Entamoeba histolytica hypothetical protein 0.0044 0.0101 0.144
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0044 0.0101 0.0342
Entamoeba histolytica hypothetical protein 0.0044 0.0101 0.144
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0033 0.0066 0.0028
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0132 0.0363
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0101 0.1194
Schistosoma mansoni hypothetical protein 0.0107 0.0295 0.1064
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0072 0.0858
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0086 0.0343
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0072 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.0405 0.6061
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0066 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0207 0.2816
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0044 0.0101 0.144
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0111 0.0306 1
Schistosoma mansoni polycystin 1-related 0.002 0.0027 0.0098
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0033 0.0066 0.0028
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.38
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0359
Echinococcus granulosus cpg binding protein 0.0027 0.005 0.005
Onchocerca volvulus 0.0098 0.0265 0.8605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0033 0.0066 0.0784
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0229 0.0665 1
Echinococcus multilocularis sentrin specific protease 8 0.0093 0.0252 0.0252
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0093 0.0252 0.2985
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.003 0.0109
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.003 0.0109
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0445 0.0445
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0101 0.144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0359
Echinococcus granulosus tumor protein p63 0.0667 0.2005 0.2005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0101 0.1194
Plasmodium vivax acetyl-CoA synthetase, putative 0.0033 0.0066 0.2012
Loa Loa (eye worm) hypothetical protein 0.01 0.0273 0.324
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0129 0.036 0.036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0111 0.0306 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0101 0.144
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0081 0.0208
Loa Loa (eye worm) hypothetical protein 0.0083 0.022 0.2615
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0101 0.0587
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0137 0.0137
Brugia malayi TAR-binding protein 0.0287 0.0843 1
Onchocerca volvulus 0.002 0.0027 0.0714
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0072 0.1011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0101 0.1194
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.003 0.0109
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Entamoeba histolytica hypothetical protein 0.0107 0.0295 0.4381
Trichomonas vaginalis antibiotic synthetase, putative 0.0033 0.0066 0.0915
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0086 0.1217
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0101 0.0363
Brugia malayi beta-lactamase family protein 0.0032 0.0065 0.0776
Entamoeba histolytica acyl-CoA synthetase, putative 0.0111 0.0306 0.4561
Schistosoma mansoni hypothetical protein 0.0334 0.0989 0.357
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0271 0.4022
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0044 0.0101 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.003 0.0816
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Loa Loa (eye worm) hypothetical protein 0.01 0.0271 0.3214
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0044 0.0101 0.0101
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0072 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Schistosoma mansoni coup transcription factor 0.0021 0.003 0.0109
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0137 0.0137
Loa Loa (eye worm) TAR-binding protein 0.0287 0.0843 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0101 0.0884
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0072 0.1011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0207 0.2816
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0044 0.0101 0.0274
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0129 0.036 0.5378
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0081 0.0216
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0033 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0066 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.003 0.0109
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0033 0.0066 0.0915
Brugia malayi hypothetical protein 0.002 0.0027 0.0322
Schistosoma mansoni tar DNA-binding protein 0.0287 0.0843 0.3044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0776
Entamoeba histolytica acyl-CoA synthetase, putative 0.0111 0.0306 0.4561
Entamoeba histolytica protein kinase rad3, putative 0.0129 0.036 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0229 0.0665 0.7892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0229 0.0665 0.183
Echinococcus multilocularis Zinc finger, PHD finger 0.0044 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0226 0.3339
Brugia malayi CXXC zinc finger family protein 0.0026 0.0045 0.0538
Leishmania major 4-coumarate:coa ligase-like protein 0.0111 0.0306 0.0835
Schistosoma mansoni lipoxygenase 0.0056 0.0137 0.0495
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0093 0.0252 0.3729
Leishmania major 4-coumarate:coa ligase-like protein 0.0111 0.0306 0.0835
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0044 0.0101 0.0101
Schistosoma mansoni rab6-interacting 0.002 0.0027 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0287 0.0843 0.3044
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0065 0.1978
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0101 0.144
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0072 0.0858
Brugia malayi nuclear receptor NHR-88 0.0021 0.003 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0132 0.1908
Loa Loa (eye worm) hypothetical protein 0.0111 0.0306 0.3636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0101 0.0101
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0111 0.0306 1
Echinococcus multilocularis serine protein kinase ATM 0.0129 0.036 0.036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0295 0.0295
Echinococcus multilocularis 0.0044 0.0101 0.0101
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0229 0.0665 0.0665
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0093 0.0252 0.3729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Leishmania major acetyl-CoA synthetase, putative 0.0033 0.0066 0.0168
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.0065 0.0241
Entamoeba histolytica hypothetical protein 0.0107 0.0295 0.4381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0229 0.0665 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0065 0.0172
Entamoeba histolytica hypothetical protein 0.0044 0.0101 0.144
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0229 0.0665 0.2402
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0033 0.0066 0.0784
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0132 0.1908
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0359
Leishmania major hypothetical protein, conserved 0.1192 0.361 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.0274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.003
Trypanosoma brucei glucosidase, putative 0.0035 0.0072 0.1011
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0039 0.0086 0.1217
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0081 0.0081
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0086 0.0343
Echinococcus granulosus sentrin specific protease 7 0.0176 0.0503 0.0503
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.003 0.0109
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.38
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0359
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Trichomonas vaginalis esterase, putative 0.0032 0.0065 0.0905
Loa Loa (eye worm) hypothetical protein 0.0044 0.0101 0.1194
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.144
Schistosoma mansoni hypothetical protein 0.002 0.0027 0.0098
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.0065 0.0241
Brugia malayi hypothetical protein 0.0107 0.0295 0.3495
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0065 0.0905
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0129 0.036 0.4276
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0144 0.3249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0132 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Echinococcus granulosus RUN 0.002 0.0027 0.0027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0101 0.1194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0101 0.1194
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0306 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.0263
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.144
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0072 0.1011
Entamoeba histolytica heat shock transcription factor, putative 0.01 0.0273 0.4055
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0033 0.0066 0.0784
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.003 0.003
Echinococcus granulosus sentrin specific protease 8 0.0093 0.0252 0.0252
Brugia malayi RNA binding protein 0.0287 0.0843 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0044 0.0101 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0101 0.144
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0229 0.0665 1
Schistosoma mansoni cpg binding protein 0.0027 0.005 0.018
Leishmania major hypothetical protein, conserved 0.0032 0.0065 0.0166
Echinococcus multilocularis sentrin specific protease 7 0.0176 0.0503 0.0503
Echinococcus granulosus expressed conserved protein 0.0136 0.0383 0.0383
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0065 0.0905
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0265 0.0955
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0229 0.0665 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0359
Onchocerca volvulus 0.0033 0.0066 0.2007
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0369 0.1094 0.395
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0033 0.0066 0.0066
Trypanosoma cruzi target of rapamycin kinase 3 0.0229 0.0665 0.1901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0083 0.022 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0144 0.1705
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0229 0.0665 0.1901
Plasmodium falciparum acyl-CoA synthetase 0.0083 0.022 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0044 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0098 0.0265 0.3139
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.0065 0.0241
Trichomonas vaginalis antibiotic synthetase, putative 0.0033 0.0066 0.0915
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0111 0.0306 0.464
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0111 0.0306 1
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0066 0.0784
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.102
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0359
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0066 0.0174
Loa Loa (eye worm) RNA binding protein 0.0287 0.0843 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0295 0.0295
Leishmania major phosphatidylinositol kinase, putative 0.0044 0.0101 0.0263
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0085 0.0226 0.268
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0033 0.0066 0.0253
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0044 0.0101 0.0101
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0083 0.022 0.307
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0086 0.1217
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0081 0.1136
Brugia malayi MAP kinase sur-1 0.0054 0.0132 0.1561
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.003 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0065 0.0776
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0229 0.0665 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0132 0.0132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0049 0.0116 0.0846
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0033 0.0066 0.0028
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0044 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0207 0.2816
Entamoeba histolytica hypothetical protein 0.0107 0.0295 0.4381
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0065 0.0172
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0086 0.031
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0044 0.0101 0.1194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0068
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0033 0.0066 0.0028
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0132 0.0363
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0081 0.0081
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.0065 0.0241
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0229 0.0665 0.2402
Brugia malayi steroid hormone receptor 0.0021 0.003 0.0359
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0086 0.1217
Trypanosoma cruzi hypothetical protein, conserved 0.1148 0.3476 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.003 0.0359
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0229 0.0665 0.183
Loa Loa (eye worm) phosphatidylinositol 3 0.0229 0.0665 0.7892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0044 0.0101 0.144
Schistosoma mansoni hypothetical protein 0.01 0.0271 0.0978
Giardia lamblia Sentrin specific protease, putative 0.0039 0.0086 0.0091
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0101 0.1194
Brugia malayi FAT domain containing protein 0.01 0.0271 0.3214
Mycobacterium ulcerans acetyl-CoA synthetase 0.0033 0.0066 0.0028
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0072 0.1011
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0044 0.0101 0.38
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0229 0.0665 0.0665
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0144 0.0405 0.6061
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0101 0.0363
Loa Loa (eye worm) hypothetical protein 0.0083 0.022 0.2615
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0132 0.0132
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0101 0.144
Echinococcus granulosus geminin 0.0334 0.0989 0.0989
Echinococcus granulosus serine protein kinase ATM 0.0129 0.036 0.036
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.0065 0.0241
Onchocerca volvulus 0.0026 0.0045 0.1317
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0065 0.0905
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0229 0.0665 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0132 0.1561
Entamoeba histolytica heat shock transcription factor, putative 0.01 0.0273 0.4055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Trypanosoma brucei protein kinase, putative 0.0054 0.0132 0.1908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0039 0.0086 0.0231
Loa Loa (eye worm) hypothetical protein 0.017 0.0487 0.578
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0044 0.0101 0.0101
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0086 0.1217
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0066 0.0784
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0081 0.0081
Mycobacterium ulcerans hypothetical protein 0.0111 0.0306 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0065 0.0236
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0033 0.0066 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0287 0.0843 0.3044
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0132 0.1908
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0044 0.0101 0.0274
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0111 0.0306 0.464
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0111 0.0306 0.3636
Entamoeba histolytica hypothetical protein 0.0129 0.036 0.5378
Entamoeba histolytica hypothetical protein 0.0107 0.0295 0.4381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0101 0.1194
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0229 0.0665 0.0665
Schistosoma mansoni tar DNA-binding protein 0.0287 0.0843 0.3044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0445 0.5277
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.1217
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0306 0.3636
Brugia malayi RNA recognition motif domain containing protein 0.0287 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.022 0.2615
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0144 0.0519
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0033 0.0066 0.0028
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0044 0.0101 0.144
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0033 0.0066 0.0028
Mycobacterium leprae conserved hypothetical protein 0.0044 0.0101 0.1461
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0229 0.0665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0405 0.6061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.003
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0129 0.036 0.1302
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0101 0.0587
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0039 0.0086 0.0223
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0101 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0101 0.144
Plasmodium vivax sentrin-specific protease 2, putative 0.0039 0.0086 0.3041
Entamoeba histolytica hypothetical protein 0.0044 0.0101 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.144
Schistosoma mansoni fkbp-rapamycin associated protein 0.0129 0.036 0.1302
Onchocerca volvulus 0.0033 0.0066 0.2007
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0033 0.0066 0.0174
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0445 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Echinococcus granulosus dnaJ subfamily B 0.0369 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0129 0.036 0.4276
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.38
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.1217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0359
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0066 0.0915
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0044 0.0101 0.1194
Echinococcus multilocularis sentrin specific protease 1 0.0039 0.0086 0.0086
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0144 0.3249
Brugia malayi ecdysteroid receptor 0.0021 0.003 0.0359
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0085 0.0226 0.0635
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Leishmania major phosphatidylinositol kinase related protein, putative 0.0044 0.0101 0.0263
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0101 0.0274
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0144 0.0144
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0033 0.0066 0.0784
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.003 0.0359
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0066 0.0253
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.003 0.003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0101 0.0587
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0033 0.0066 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0081 0.1136
Echinococcus multilocularis tumor protein p63 0.0667 0.2005 0.2005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0066 0.0174
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0044 0.0101 0.144
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0295 0.1064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0081 0.0957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0065 0.0236
Schistosoma mansoni hypothetical protein 0.0044 0.0101 0.0363
Trypanosoma brucei SUMO1/Ulp2, putative 0.0039 0.0086 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.1217
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0044 0.0101 0.0274
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0144 0.167
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0044 0.0101 0.0363
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0065 0.0905
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0033 0.0066 0.0028
Plasmodium falciparum sentrin-specific protease 1 0.0039 0.0086 0.3041
Onchocerca volvulus 0.0044 0.0101 0.3156
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Leishmania major acetyl-CoA synthetase, putative 0.0033 0.0066 0.0168
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0033 0.0066 0.2012
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0033 0.0066 0.0253
Echinococcus multilocularis geminin 0.0334 0.0989 0.0989
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0065 0.0905
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0287 0.0843 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0072 0.1011
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0322
Trichomonas vaginalis Sentrin-specific protease, putative 0.0093 0.0252 0.3729
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.003 0.0816
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0101 0.144
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0044 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0776
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0229 0.0665 0.0665
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0229 0.0665 0.1901
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.144
Onchocerca volvulus 0.0021 0.003 0.0816
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0445 0.5277
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0027 0.0027
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0065 0.0776
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0101 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0132 0.1908
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0081 0.0216
Schistosoma mansoni acetyl-CoA synthetase 0.0033 0.0066 0.0239
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0027 0.0027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0129 0.036 0.4276
Echinococcus granulosus sentrin specific protease 1 0.0039 0.0086 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0101 0.1194
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0072 0.0192
Onchocerca volvulus 0.0032 0.0065 0.1985
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0132 0.0132
Giardia lamblia Phosphatidylinositol 4-kinase 0.0044 0.0101 0.0342
Plasmodium vivax acyl-CoA synthetase, putative 0.0083 0.022 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3281 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0229 0.0665 0.1901
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0784
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0044 0.0101 0.0274
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0072 0.1011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0776
Schistosoma mansoni hypothetical protein 0.0334 0.0989 0.357
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0111 0.0306 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.003
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0044 0.0101 0.144
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0132 0.0363
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0081 0.1136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0101 0.144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0776
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.01 0.0271 0.0271
Echinococcus multilocularis tar DNA binding protein 0.0287 0.0843 0.0843
Onchocerca volvulus Heat shock factor protein 2 homolog 0.01 0.0273 0.889
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.003 0.0109
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.003 0.003
Toxoplasma gondii FATC domain-containing protein 0.0129 0.036 0.4918
Schistosoma mansoni cpg binding protein 0.0026 0.0045 0.0164
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0144 0.0144
Onchocerca volvulus 0.0032 0.0065 0.1985
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0072 0.0072
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0044 0.0101 0.0342
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0044 0.0101 0.0101
Plasmodium vivax hypothetical protein 0.0044 0.0101 0.38
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0322
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0033 0.0066 0.0253
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0033 0.0066 0.0915
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0086 0.1217
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Onchocerca volvulus 0.0111 0.0306 1
Echinococcus granulosus tar DNA binding protein 0.0287 0.0843 0.0843
Onchocerca volvulus 0.0032 0.0065 0.1985
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0081 0.1136
Onchocerca volvulus 0.0044 0.0101 0.3156
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0129 0.036 0.1022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.0065 0.0241
Entamoeba histolytica heat shock transcription factor, putative 0.01 0.0273 0.4055
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0072 0.1011
Echinococcus multilocularis microtubule associated protein 2 0.0917 0.2769 0.2769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Brugia malayi beta-lactamase family protein 0.0032 0.0065 0.0776
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0101 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.036 0.5378
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.1217
Leishmania major 4-coumarate:coa ligase-like protein 0.0111 0.0306 0.0835
Echinococcus multilocularis RUN 0.002 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0226 0.3339
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0132 0.1908
Echinococcus multilocularis cpg binding protein 0.0027 0.005 0.005
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0306 0.3636
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0207 0.2816
Brugia malayi nuclear hormone receptor 0.0021 0.003 0.0359
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0101 0.1194
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0033 0.0066 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0359
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0033 0.0066 0.0028
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0101 0.0587
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0129 0.036 0.5378
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0033 0.0066 0.0174
Echinococcus granulosus microtubule associated protein 2 0.0917 0.2769 0.2769
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.003 0.0359
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0081 0.0081
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0101 0.144
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0081 0.0291
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0033 0.0066 0.0253
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0086 0.1217
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0132 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Brugia malayi hypothetical protein 0.002 0.0027 0.0322
Onchocerca volvulus 0.0037 0.0078 0.2405
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0111 0.0306 0.3636
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0359
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0066 0.0253
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0132 0.0475
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0101 0.144
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0132 0.0871
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.003 0.0109
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0044 0.0101 0.1194
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0044 0.0101 0.38
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0066 0.0253
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0359
Schistosoma mansoni alpha glucosidase 0.0035 0.0072 0.0261
Onchocerca volvulus 0.0033 0.0066 0.2007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0683 0.8105
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0144 0.0405 0.5669
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.003 0.0359
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0101 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.0665 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0229 0.0665 0.183
Giardia lamblia GTOR 0.0229 0.0665 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0144 0.0383
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0101 0.1194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0229 0.0665 0.7892
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0093 0.0252 0.3729
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0006 0.0068
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0093 0.0252 0.3729
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0033 0.0066 0.0253
Brugia malayi HSF-type DNA-binding domain containing protein 0.01 0.0273 0.324
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.0065 0.0241
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0044 0.0101 0.0274
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.003 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.0134 0.0484
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0044 0.0101 0.38
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.102
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0086 0.1217
Schistosoma mansoni cpg binding protein 0.0027 0.005 0.018
Onchocerca volvulus 0.0091 0.0243 0.7888
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0033 0.0066 0.0253
Mycobacterium tuberculosis Conserved protein 0.0032 0.0065 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0066 0.0784
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0176 0.0503 0.7546
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0359
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0039 0.0086 0.0231
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0044 0.0101 0.0274
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0065 0.0905
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0683 0.8105
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0101 0.0274
Loa Loa (eye worm) phosphatidylinositol kinase 0.0044 0.0101 0.1194
Loa Loa (eye worm) Ulp1 protease 0.0093 0.0252 0.2985
Mycobacterium tuberculosis Conserved protein 0.0032 0.0065 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0066 0.0784
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0144 0.0405 0.481
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0066 0.0028
Schistosoma mansoni loxhd1 0.002 0.0027 0.0098
Schistosoma mansoni alpha-glucosidase 0.0135 0.0378 0.1366
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0132 0.1564
Echinococcus multilocularis dnaJ subfamily B 0.0369 0.1094 0.1094
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0086 0.0343

Activities

Activity type Activity value Assay description Source Reference
XI50 (binding) 0 Inhibition of human GIVA cPLA2 ChEMBL. 17672443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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