Detailed information for compound 433209

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.58 | Formula: C31H30N2O6
  • H donors: 1 H acceptors: 3 LogP: 5.18 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCC#Cc1cn(C/C=C/2\OC(=O)C(=C2OCc2ccccc2)OCc2ccccc2)c(=O)[nH]c1=O
  • InChi: 1S/C31H30N2O6/c1-2-3-4-5-12-17-25-20-33(31(36)32-29(25)34)19-18-26-27(37-21-23-13-8-6-9-14-23)28(30(35)39-26)38-22-24-15-10-7-11-16-24/h6-11,13-16,18,20H,2-5,19,21-22H2,1H3,(H,32,34,36)/b26-18-
  • InChiKey: BCBIQDAVQVFABQ-ITYLOYPMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0174 0.182
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0133 0.0915 0.1161
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1311 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.073 0.192
Echinococcus multilocularis lamin 0.0027 0.0097 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0053 0.0301 0.2923
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0138 0.0136
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0039 0.0037
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0099 0.0187
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0567 0.4266 0.8188
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0212 0.0335
Plasmodium vivax hypothetical protein 0.0053 0.0301 0.3171
Echinococcus multilocularis tumor protein p63 0.0338 0.2499 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.1029 0.1919
Entamoeba histolytica protein kinase, putative 0.0051 0.0284 0.0476
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0138
Echinococcus multilocularis high voltage activated calcium channel beta 0.0087 0.056 0.0559
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0039 0.0037
Brugia malayi phosphofructokinase 0.0109 0.073 0.1401
Onchocerca volvulus 0.0101 0.0666 0.2804
Toxoplasma gondii CMGC kinase, CK2 family 0.0137 0.0948 0.6111
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0486 0.3634 0.3633
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0948 0.1761
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0099 0.0116
Giardia lamblia Kinase, PLK 0.0192 0.1371 0.4616
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0054 0.003
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0041 0.0072
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0118 0.0911
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Echinococcus granulosus serine protein kinase ATM 0.0126 0.0859 0.0857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0336 0.0575
Schistosoma mansoni kinase 0.0099 0.0653 0.0829
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0138 0.0136
Brugia malayi Death domain containing protein 0.0014 0.0002 0.0001
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0053 0.0301 0.0381
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0174 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Brugia malayi hypothetical protein 0.0101 0.0667 0.128
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0179 0.1271 0.2441
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0118 0.0152
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0051 0.0284 0.052
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0486 0.3634 0.3633
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0174 0.0249
Loa Loa (eye worm) phosphatidylinositol 3 0.0913 0.693 1
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Echinococcus granulosus lamin 0.0027 0.0097 0.0095
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0192 0.1371 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.1729 0.3274
Echinococcus multilocularis musashi 0.0027 0.0097 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0443 0.0783
Schistosoma mansoni hypothetical protein 0.0168 0.1188 0.1508
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0301 0.0433
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0133 0.0915 0.9647
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0003 0.0001
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0169 0.0322
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0362 0.1776
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0039 0.0054
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0126 0.0859 0.109
Echinococcus granulosus lamin dm0 0.0027 0.0097 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.1065 0.1988
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.073 0.1339
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0689 0.5202 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0192 0.1371 0.1976
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Loa Loa (eye worm) hypothetical protein 0.0032 0.0138 0.0198
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.004 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0284 0.0476
Trypanosoma brucei protein kinase, putative 0.0051 0.0284 0.1348
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.073 0.1339
Plasmodium falciparum glycogen synthase kinase 3 0.0051 0.0284 0.2736
Giardia lamblia GTOR 0.0238 0.1729 0.5936
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0054
Echinococcus granulosus Ankyrin 0.0015 0.0003 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0746 0.137
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0301 0.3171
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.005 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.0251
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0039 0.0037
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.073 0.1339
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0041 0.0004
Toxoplasma gondii hypothetical protein 0.0054 0.0304 0.196
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0054
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0174 0.0736
Echinococcus granulosus high voltage activated calcium channel beta 0.0087 0.056 0.0559
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.0251
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0068 0.0413 0.0411
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0039 0.0037
Entamoeba histolytica protein kinase rad3, putative 0.0111 0.0746 0.137
Onchocerca volvulus 0.0053 0.0301 0.1265
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Onchocerca volvulus 0.0041 0.0207 0.0865
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0201 0.1439 0.2747
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0039 0.0037
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0381 0.2832 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0238 0.1729 0.2494
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.1587 0.2999
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0039 0.0047
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0362 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0133 0.0915 0.1696
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.237 0.4556
Toxoplasma gondii FATC domain-containing protein 0.0126 0.0859 0.5538
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0319 0.2349 0.4474
Brugia malayi Casein kinase II, alpha chain 0.0137 0.0948 0.182
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0915 0.2416
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0174 0.0261
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0053 0.0301 0.3171
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0065 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0301 0.3781
Onchocerca volvulus 0.0027 0.0097 0.0403
Schistosoma mansoni fkbp-rapamycin associated protein 0.0111 0.0746 0.0947
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0053 0.0301 0.3171
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0133 0.0915 0.1696
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0119 0.0149
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0138 0.0136
Onchocerca volvulus 0.0053 0.0301 0.1265
Brugia malayi intermediate filament protein 0.0027 0.0097 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0301 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0039 0.0072
Entamoeba histolytica hypothetical protein 0.0053 0.0301 0.0509
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0118 0.0152
Echinococcus multilocularis expressed protein 0.0374 0.2772 0.2771
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0065 0.0122
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0118 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0413 0.0724
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0133 0.0915 0.1696
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0053 0.0301 0.0553
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0138 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.141 0.2656
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0002 0.0001
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.073 0.0926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1409 0.2655
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0174 0.1525
Echinococcus multilocularis 0.0053 0.0301 0.03
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0689 0.5202 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Entamoeba histolytica hypothetical protein 0.0053 0.0301 0.0509
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0118 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0138 0.0136
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0002 0.00000002877
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0238 0.1729 0.9333
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0579 0.0577
Brugia malayi hypothetical protein 0.0036 0.0169 0.0321
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.073 0.1051
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.073 0.1339
Leishmania major casein kinase II, putative 0.0137 0.0948 0.2506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0859 0.1589
Entamoeba histolytica serine/threonine protein kinase, putative 0.0192 0.1371 0.2579
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0284 0.0283
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.073 0.0728
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0099 0.0187
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0238 0.1729 0.4603
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0254 0.185 0.3508
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0229 0.1656 0.1655
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0039 0.0047
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1034 0.7865 0.7865
Schistosoma mansoni hypothetical protein 0.0053 0.0301 0.0381
Onchocerca volvulus 0.0235 0.1705 0.719
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0039 0.0037
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0301 0.0433
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0072 0.0449 0.0837
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.073 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0212 0.0335
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0137 0.0948 1
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0174 0.1525
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0304 0.0514
Entamoeba histolytica hypothetical protein 0.0567 0.4266 0.8188
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.073 0.1339
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0133 0.0915 0.1696
Trypanosoma cruzi target of rapamycin kinase 3 0.022 0.1588 0.3033
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.1439 0.2075
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0111 0.0746 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1371 0.1741
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0118 0.0758
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.1371 0.2614
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0746 0.1432
Echinococcus granulosus casein kinase ii subunit alpha 0.0137 0.0948 0.0946
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.237 0.2369
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0097 0.0184
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0099 0.0116
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0301 0.1943
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0301 0.0577
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.237 0.2369
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0053 0.0301 0.03
Toxoplasma gondii target of rapamycin (TOR), putative 0.0215 0.1551 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0503 0.3768 0.7222
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0119 0.0118
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0039 0.0054
Echinococcus granulosus geminin 0.0168 0.1188 0.1186
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0053 0.0301 0.0381
Loa Loa (eye worm) hypothetical protein 0.0111 0.0746 0.1075
Brugia malayi intracellular kinase 0.0051 0.0284 0.0544
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0179 0.1271 0.1832
Loa Loa (eye worm) calcium channel 0.0032 0.0138 0.0198
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0118 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1409 0.2655
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0362 0.0626
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0118 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.1029 0.1919
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1484 0.214
Brugia malayi Protein kinase domain containing protein 0.0322 0.237 0.4556
Brugia malayi hypothetical protein 0.0471 0.3526 0.6778
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0238 0.1729 0.1728
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0133 0.0915 0.1696
Giardia lamblia Hypothetical protein 0.0053 0.0301 0.0677
Brugia malayi hypothetical protein 0.0163 0.1151 0.221
Loa Loa (eye worm) hypothetical protein 0.0486 0.3634 0.5244
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0559 0.0558
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0121 0.0823 0.5307
Echinococcus granulosus single minded 2 0.0036 0.0169 0.0167
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0192 0.1371 0.1369
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0238 0.1729 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.1446 0.2725
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.073 0.1339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0119 0.0149
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0039 0.0037
Brugia malayi follicle stimulating hormone receptor 0.0237 0.1715 0.3296
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0459 0.0458
Loa Loa (eye worm) hypothetical protein 0.0068 0.0413 0.0594
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0053 0.0301 0.0509
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0301 0.03
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.0666 0.1278
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.185 0.3508
Onchocerca volvulus 0.0036 0.0169 0.0705
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0189 0.1351 0.7242
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0174 0.182
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0689 0.5202 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0039 0.0047
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0238 0.1729 0.2197
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0189 0.1351 0.3587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0041 0.0007
Echinococcus granulosus protein kinase shaggy 0.0051 0.0284 0.0283
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0138 0.0136
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0301 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0336 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0823 0.1519
Toxoplasma gondii hypothetical protein 0.0019 0.0041 0.0264
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0039 0.0037
Leishmania major phosphatidylinositol 4-kinase, putative 0.0053 0.0301 0.077
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0915 0.4831
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0051 0.0284 0.1833
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0068 0.0414 0.0771
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0065 0.0092
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0174 0.0307
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Entamoeba histolytica hypothetical protein 0.0126 0.0859 0.1589
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0138 0.0136
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0039 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0119 0.0149
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0284 0.0408
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0284 0.0476
Schistosoma mansoni lamin 0.0027 0.0097 0.0121
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0301 0.1442
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0304 0.0514
Giardia lamblia Casein kinase II beta chain 0.0037 0.0174 0.0207
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0689 0.5202 1
Plasmodium vivax unspecified product 0.0137 0.0948 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0449 0.0645
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0301 0.0433
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0174 0.0172
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0118 0.1228
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0053 0.0301 0.3171
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0053 0.0301 0.0553
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0122 0.0829 0.153
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.017
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0689 0.5202 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0667 0.0961
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0174 0.0725
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0039 0.0037
Schistosoma mansoni single-minded 0.0049 0.0266 0.0336
Brugia malayi Serotonin receptor 0.0467 0.3491 0.6711
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0118 0.0152
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0054 0.003
Onchocerca volvulus 0.0101 0.0666 0.2804
Onchocerca volvulus 0.0096 0.0632 0.2662
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0133 0.0915 0.1161
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0362 0.1776
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0065 0.008
Schistosoma mansoni intermediate filament proteins 0.0027 0.0097 0.0121
Echinococcus granulosus tumor protein p63 0.0338 0.2499 0.2498
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0302 0.2218 0.2819
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0169 0.1861
Loa Loa (eye worm) phosphatidylinositol 3 0.0189 0.1351 0.1948
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.185 0.3508
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0041 0.0419
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0118 0.0911
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.1715 0.2474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0301 0.03
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0169 0.0167
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0284 0.0614
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0138 0.0174
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.073 0.1339
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0273 0.0344
Schistosoma mansoni hypothetical protein 0.0096 0.0632 0.0802
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0192 0.1371 0.364
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.1371 0.2614
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0284 0.0359
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0041 0.0264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.0859 0.1649
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0301 0.03
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.185 0.3555
Toxoplasma gondii hypothetical protein 0.0019 0.0041 0.0264
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0118 0.0758
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0138 0.0174
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0238 0.1729 0.3305
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.3526 0.3525
Echinococcus multilocularis Ankyrin 0.0015 0.0003 0.0001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0039 0.0047
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0041 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0119 0.0118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0254 0.185 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0039 0.0072
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0111 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.185 0.3508
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0175 0.1237 0.4122
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.1587 0.2999
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0229 0.1656 0.3165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.1268 0.2381
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0111 0.0746 0.0744
Schistosoma mansoni survival motor neuron protein 0.0096 0.0632 0.0802
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0133
Leishmania major phosphatidylinositol 3-kinase, putative 0.0133 0.0915 0.2416
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0065 0.0092
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0559 0.0558
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0133 0.0915 0.0913
Leishmania major phosphatidylinositol kinase, putative 0.0053 0.0301 0.077
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0118 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0488 0.3652 0.7021
Brugia malayi Uncoordinated protein 44 0.0014 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.1207 0.2263
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0174 0.0307
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0039 0.0072
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0087 0.056 0.071
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.073 0.1379
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.03 0.22 0.4187
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0301 0.1943
Entamoeba histolytica casein kinase, putative 0.0137 0.0948 0.1761
Onchocerca volvulus Serine\/threonine kinase homolog 0.0192 0.1371 0.5778
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0179 0.1268 0.6784
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1704 0.3225
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0065 0.008
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0139 0.0965 0.5111
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.237 0.3419
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.009 0.0585 0.3008
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0133 0.0915 0.9634
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0229 0.1656 0.1655
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0118 0.1228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0169 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.1729 0.3274
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0579 0.0577
Brugia malayi Cytochrome P450 family protein 0.003 0.012 0.0228
Brugia malayi SH2 domain containing protein 0.034 0.2515 0.4834
Schistosoma mansoni protein kinase 0.0137 0.0948 0.1203
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0579 0.0734
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0249 0.1809 0.2608
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0169 0.0212
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.073 0.0926
Loa Loa (eye worm) hypothetical protein 0.005 0.0273 0.0391
Loa Loa (eye worm) phosphatidylinositol kinase 0.0053 0.0301 0.0433
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0053 0.0301 0.1943
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1034 0.7865 0.7865
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0039 0.0047
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0053 0.0301 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0284 0.0408
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0039 0.0037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0362 0.067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0054
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0053 0.0301 0.2923
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0039 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.073 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0141
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0039 0.0037
Echinococcus multilocularis casein kinase ii subunit alpha 0.0137 0.0948 0.0946
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0097 0.0138
Toxoplasma gondii ck2 beta subunit 0.0037 0.0174 0.1119
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0065 0.008
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0099 0.0097
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0829 0.153
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Brugia malayi 6-phosphofructokinase 0.0109 0.073 0.1401
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0039 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0229 0.1656 0.3165
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0362 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0301 0.0509
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.004 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.1268 0.2381
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.1587 0.2999
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Echinococcus granulosus cyclin dependent kinase 19 0.0134 0.0924 0.0922
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0039 0.0037
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.3526 0.3525
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Plasmodium falciparum casein kinase 2, alpha subunit 0.0137 0.0948 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0138 0.0136
Echinococcus multilocularis cyclin dependent kinase 19 0.0134 0.0924 0.0922
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0118 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.141 0.2656
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0238 0.1729 0.3274
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0099 0.0123
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0238 0.1729 0.4603
Echinococcus granulosus expressed conserved protein 0.0082 0.0521 0.0519
Trypanosoma brucei target of rapamycin kinase 3, putative 0.022 0.1588 0.8551
Onchocerca volvulus 0.0027 0.0097 0.0403
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0689 0.5202 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0028
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0174 0.1119
Loa Loa (eye worm) hypothetical protein 0.034 0.2515 0.3628
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0133 0.0915 0.5896
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0345 0.2554 0.4909
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0126 0.0859 0.1628
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0924 0.1172
Schistosoma mansoni lamin 0.0027 0.0097 0.0121
Echinococcus granulosus expressed protein 0.0374 0.2772 0.2771
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0632 0.1213
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0133 0.0915 0.1318
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0471 0.3526 0.5087
Trypanosoma cruzi casein kinase II, putative 0.0137 0.0948 0.18
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.1268 0.2381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.1142 0.2138
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0119 0.0769
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0301 0.0577
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0915 0.1735
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0138 0.0136
Loa Loa (eye worm) hypothetical protein 0.0101 0.0666 0.0959
Echinococcus multilocularis Zinc finger, PHD finger 0.0133 0.0915 0.0913
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.073 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0039 0.0037
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0238 0.1729 0.9333
Plasmodium vivax SET domain protein, putative 0.003 0.0119 0.1247
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0051 0.0284 0.0724
Brugia malayi 6-phosphofructokinase 0.0109 0.073 0.1401
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0284 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0634 0.1153
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.004 0.0056
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0053 0.0301 0.0381
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0039 0.0037
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0229 0.1656 0.2104
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.073 0.3811
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0254 0.185 0.3538
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0054 0.0052
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0134 0.0924 0.1331
Brugia malayi Pre-SET motif family protein 0.003 0.0119 0.0227
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0039 0.0047
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.0251
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0002 0.0001
Loa Loa (eye worm) phosphofructokinase 0.0109 0.073 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Brugia malayi Cytochrome P450 family protein 0.0019 0.004 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0301 0.0433
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0097 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1409 0.2655
Brugia malayi serine/threonine-protein kinase plk-2 0.0192 0.1371 0.2633
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.073 0.1051
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0133 0.0915 0.1756
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0634 0.1153
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0138 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0446 0.3329 0.639
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.237 1
Loa Loa (eye worm) gastrulation defective protein 1 0.0131 0.0897 0.1293
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.237 0.3012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.1446 0.2725
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0118 0.0152
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.141 0.2656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Loa Loa (eye worm) hypothetical protein 0.0053 0.0301 0.0433
Brugia malayi hypoxia-induced factor 1 0.0151 0.1053 0.2022
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.002 0.0023
Brugia malayi Protein kinase domain containing protein 0.0018 0.0028 0.0051
Onchocerca volvulus 0.0051 0.0284 0.1193
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.1053 0.1518
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0133 0.0915 0.0913
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.615 0.615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.1268 0.2381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.1729 0.3322
Onchocerca volvulus 0.005 0.0273 0.1143
Echinococcus granulosus intermediate filament protein 0.0027 0.0097 0.0095
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0039 0.0072
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.004 0.0056
Plasmodium vivax glycogen synthase kinase 3, putative 0.0051 0.0284 0.299
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0053 0.0301 0.0553
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.022 0.1588 0.4223
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0002 0.00000002877
Mycobacterium leprae conserved hypothetical protein 0.0053 0.0301 0.3781
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0099 0.0097
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0362 0.036
Echinococcus multilocularis lamin dm0 0.0027 0.0097 0.0095
Entamoeba histolytica hypothetical protein 0.0053 0.0301 0.0509
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0238 0.1729 0.1728
Leishmania major phosphatidylinositol kinase related protein, putative 0.0068 0.0414 0.1074
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0284 0.0476
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.237 0.3419
Leishmania major cytochrome p450-like protein 0.0019 0.004 0.007
Brugia malayi FAT domain containing protein 0.0068 0.0413 0.0791
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0126 0.0859 0.4525
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0039 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.1551 0.293
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0174 0.0261
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0138 0.0174
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0002 0.000000036582
Brugia malayi PAS domain containing protein 0.0049 0.0266 0.051
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0284 0.0283
Leishmania major hypothetical protein, unknown function 0.0053 0.0301 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.1351 0.2541
Loa Loa (eye worm) CYP4Cod1 0.0019 0.004 0.0056
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.0259 0.0372
Schistosoma mansoni hypothetical protein 0.0168 0.1188 0.1508
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.012 0.0171
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0238 0.1729 0.3305
Brugia malayi Cytochrome P450 family protein 0.0019 0.004 0.0075
Giardia lamblia Kinase, CMGC CK2 0.0137 0.0948 0.3059
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0459 0.0458
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1034 0.7865 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0054
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0579 0.0734
Loa Loa (eye worm) hypothetical protein 0.0163 0.1151 0.1659
Schistosoma mansoni hypothetical protein 0.0051 0.0287 0.0362
Brugia malayi PXA domain containing protein 0.0021 0.005 0.0093
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0068 0.0413 0.0411
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.073 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0362 0.067
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0284 0.0476
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.073 0.0728
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0207 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.0362 0.0626
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0362 0.036
Brugia malayi Csnk2b protein 0.0037 0.0174 0.0331
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0212 0.038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0174 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.141 0.2656
Echinococcus multilocularis serine protein kinase ATM 0.0126 0.0859 0.0857
Giardia lamblia Phosphatidylinositol 4-kinase 0.0053 0.0301 0.0677
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.0362 0.0458
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0099 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Echinococcus multilocularis geminin 0.0168 0.1188 0.1186
Echinococcus multilocularis expressed conserved protein 0.0082 0.0521 0.0519
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0174 0.0261
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0133 0.0915 0.0913
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0915 0.1735
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0229 0.1656 0.3182
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0041 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.1729 0.3274
Brugia malayi Protein kinase domain containing protein 0.0134 0.0924 0.1773
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0174 0.0725
Schistosoma mansoni hypothetical protein 0.0082 0.0521 0.066
Brugia malayi Pre-SET motif family protein 0.0207 0.1484 0.2851
Echinococcus granulosus bloom syndrome protein 0.0021 0.0054 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0119 0.0118
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0689 0.5202 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0039 0.0072
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Brugia malayi PXA domain containing protein 0.0021 0.005 0.0093
Schistosoma mansoni hypothetical protein 0.0068 0.0413 0.0522
Trypanosoma brucei Casein kinase II 0.0137 0.0948 0.5016
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0053 0.0301 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.1371 0.2579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.1029 0.1919
Trypanosoma brucei polo-like protein kinase 0.0192 0.1371 0.7351
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0053 0.0301 0.1442
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0133 0.0915 0.5896
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0284 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.1587 0.2999
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0174 0.0172
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0266 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0304 0.0514
Loa Loa (eye worm) RecQ helicase 0.0021 0.0054 0.0076
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0503 0.3768 0.7222
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0111 0.0746 0.141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0032 0.0044
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0138 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0053 0.0301 0.03
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.0362 0.0626
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0118 0.0152
Leishmania major phosphatidylinositol 3-kinase, putative 0.0179 0.1268 0.3365
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0636 0.4791 0.9205
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0948 0.1761
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0054 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.1587 0.2999
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0362 0.0626
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0174 0.0218
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0137 0.0948 0.1366
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0169 0.0167
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0301 0.0509
Leishmania major hypothetical protein, conserved 0.0499 0.374 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0039 0.0047
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0121 0.0823 0.1186

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 12.3 uM Cytotoxicity against human HEL cells assessed as reduction of cell growth ChEMBL. 17672445
CC50 (ADMET) = 12.3 uM Cytotoxicity against human HEL cells assessed as reduction of cell growth ChEMBL. 17672445
EC50 (functional) = 3.1 uM Antiviral activity against CMV Davis in human HEL cells after 7 days ChEMBL. 17672445
EC50 (functional) > 4 uM Antiviral activity against thymidine kinase-positive VZV OKA in human HEL cells after 7 days ChEMBL. 17672445
EC50 (functional) > 4 uM Antiviral activity against thymidine kinase deficient VZV 07/1 in human HEL cells after 7 days ChEMBL. 17672445
EC50 (functional) > 4 uM Antiviral activity against CMV AD169 in human HEL cells after 7 days ChEMBL. 17672445
IC50 (functional) = 8.2 uM Antiproliferative activity against human CEM cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 8.2 uM Antiproliferative activity against human CEM cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 10 uM Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 10 uM Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 13 uM Antiproliferative activity against MiaPaCa2 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 13 uM Antiproliferative activity against MiaPaCa2 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 14 uM Antiproliferative activity against HeLa cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 14 uM Antiproliferative activity against SW620 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 14 uM Antiproliferative activity against HeLa cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 14 uM Antiproliferative activity against SW620 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 15 uM Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 15 uM Antiproliferative activity against H460 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 15 uM Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 15 uM Antiproliferative activity against H460 cells after 72 hrs by MTT assay ChEMBL. 17672445
IC50 (functional) = 19 uM Antiproliferative activity against human Molt4/C8 cells after 72 hrs by MTT assay ChEMBL. 17672445
MCC (ADMET) = 20 uM Cytotoxicity against human HEL cells assessed as alteration in cell morphology ChEMBL. 17672445
MCC (ADMET) = 20 uM Cytotoxicity against human HEL cells assessed as alteration in cell morphology ChEMBL. 17672445
MIC (functional) = 4.8 uM Antiviral activity against Parainfluenza 3 virus in Vero cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against VSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) = 8 uM Antiviral activity against HSV1 KOS in HEL cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against HSV2 G in HEL cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against Vaccinia virus in HEL cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against RSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against Reovirus 1 in Vero cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against Sindbis virus in Vero cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against Coxsackie virus B4 in Vero cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445
MIC (functional) > 8 uM Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus-induced cytopathogenicity ChEMBL. 17672445

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17672445
Mus musculus ChEMBL23 17672445

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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