Detailed information for compound 442599

Basic information

Technical information
  • TDR Targets ID: 442599
  • Name: (2R,3S,4S,5R)-2-[[bis(cyclohexylmethyl)amino] methyl]-5-[[(2S,3S,4S,5R)-5-[[bis(cyclohexylm ethyl)amino]methyl]-3,4-dihydroxyoxolan-2-yl] oxymethyl]oxolane-3,4-diol
  • MW: 678.982 | Formula: C39H70N2O7
  • H donors: 4 H acceptors: 4 LogP: 6.78 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1[C@@H](CN(CC2CCCCC2)CC2CCCCC2)O[C@@H]([C@H]1O)OC[C@H]1O[C@@H]([C@H]([C@@H]1O)O)CN(CC1CCCCC1)CC1CCCCC1
  • InChi: 1S/C39H70N2O7/c42-35-32(25-40(21-28-13-5-1-6-14-28)22-29-15-7-2-8-16-29)47-34(37(35)44)27-46-39-38(45)36(43)33(48-39)26-41(23-30-17-9-3-10-18-30)24-31-19-11-4-12-20-31/h28-39,42-45H,1-27H2/t32-,33-,34-,35-,36-,37-,38+,39+/m1/s1
  • InChiKey: IDHXQPROXVNPSN-JYQREJNHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3S,4S,5R)-2-[[bis(cyclohexylmethyl)amino]methyl]-5-[[(2S,3S,4S,5R)-5-[[bis(cyclohexylmethyl)amino]methyl]-3,4-dihydroxy-tetrahydrofuran-2-yl]oxymethyl]tetrahydrofuran-3,4-diol
  • (2R,3S,4S,5R)-2-[[bis(cyclohexylmethyl)amino]methyl]-5-[[(2S,3S,4S,5R)-5-[[bis(cyclohexylmethyl)amino]methyl]-3,4-dihydroxy-2-tetrahydrofuranyl]oxymethyl]tetrahydrofuran-3,4-diol
  • (2R,3S,4S,5R)-2-[[bis(cyclohexylmethyl)amino]methyl]-5-[[(2S,3S,4S,5R)-5-[[bis(cyclohexylmethyl)amino]methyl]-3,4-dihydroxy-oxolan-2-yl]oxymethyl]oxolane-3,4-diol
  • (2R,3S,4S,5R)-2-[(bis(cyclohexylmethyl)amino)methyl]-5-[[(2S,3S,4S,5R)-5-[(bis(cyclohexylmethyl)amino)methyl]-3,4-dihydroxyoxolan-2-yl]oxymethyl]oxolane-3,4-diol
  • (2R,3S,4S,5R)-2-[(bis(cyclohexylmethyl)amino)methyl]-5-[[(2S,3S,4S,5R)-5-[(bis(cyclohexylmethyl)amino)methyl]-3,4-dihydroxy-tetrahydrofuran-2-yl]oxymethyl]tetrahydrofuran-3,4-diol
  • (2R,3S,4S,5R)-2-[(bis(cyclohexylmethyl)amino)methyl]-5-[[(2S,3S,4S,5R)-5-[(bis(cyclohexylmethyl)amino)methyl]-3,4-dihydroxy-2-tetrahydrofuranyl]oxymethyl]tetrahydrofuran-3,4-diol
  • (2R,3S,4S,5R)-2-[(bis(cyclohexylmethyl)amino)methyl]-5-[[(2S,3S,4S,5R)-5-[(bis(cyclohexylmethyl)amino)methyl]-3,4-dihydroxy-oxolan-2-yl]oxymethyl]oxolane-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0141 0.1634 0.3123
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0062 0.0672 0.0672
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.007 0.0762 0.0762
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0.0872 0.1028
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0354 0.5262
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0144 0.0647
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0023 0.0188 0.0188
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0023 0.0188 0.0624
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.2741 0.2741
Loa Loa (eye worm) hypothetical protein 0.0036 0.0354 0.0676
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0172 0.0329
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0213 0.2802
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.001 0.0012
Brugia malayi Cytochrome P450 family protein 0.0016 0.0108 0.0357
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0354 0.4646
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0172 0.0329
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0122 0.0144
Echinococcus multilocularis neuropeptide receptor A26 0.0542 0.6533 0.6864
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.257
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0337 0.0354
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.8481 0.8911
Brugia malayi hypothetical protein 0.0016 0.0106 0.0353
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0.0872 0.2896
Onchocerca volvulus 0.0026 0.0233 0.1198
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0872 0.1028
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0354 0.1175
Loa Loa (eye worm) hydrolase 0.0023 0.0188 0.0359
Onchocerca volvulus 0.0079 0.0872 0.4483
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0188 0.2466
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0022 0.0074
Echinococcus multilocularis Smad4 0.0008 0.0008 0.0008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0122 0.0627
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0009
Echinococcus multilocularis protein pangolin J 0.0063 0.0687 0.0722
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0196 0.257
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0709 0.0744
Onchocerca volvulus Cirhin homolog 0.0094 0.1064 0.5471
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0337 0.0397
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.3734 0.7135
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0.0872 0.4483
Schistosoma mansoni nuclear hormone receptor 0.0008 0.001 0.0012
Brugia malayi Serotonin receptor 0.0079 0.0872 0.2896
Trypanosoma cruzi hydrolase-like protein 0.0023 0.0188 0.2466
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0172 0.0571
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3011 1
Schistosoma mansoni hypothetical protein 0.0079 0.0872 0.1028
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0484 0.0925
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1337 0.2555
Entamoeba histolytica hypothetical protein 0.0024 0.0201 0.2642
Schistosoma mansoni pangolin 0.0063 0.0687 0.081
Brugia malayi RE15519p 0.0079 0.0872 0.2896
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0108 0.1412
Mycobacterium ulcerans hydrolase 0.0023 0.0188 0.0188
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0188 0.0624
Schistosoma mansoni hypothetical protein 0.0079 0.0872 0.1028
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0023 0.0188 0.0188
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.257
Loa Loa (eye worm) hypothetical protein 0.0036 0.0354 0.0676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0112 0.0112
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Brugia malayi Melatonin receptor type 1A 0.0079 0.0872 0.2896
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Plasmodium falciparum alpha/beta hydrolase, putative 0.0023 0.0188 0.2332
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0872 0.1666
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0196 0.2911
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0122 0.0405
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0199 0.0199
Brugia malayi Alpha/beta hydrolase 0.0023 0.0188 0.0624
Brugia malayi Nuclear hormone receptor E75 0.0008 0.001 0.0034
Schistosoma mansoni hypothetical protein 0.0331 0.3955 0.4663
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0172 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Giardia lamblia Phosphoglycolate phosphatase 0.0021 0.0172 0.4314
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0354 0.0354
Plasmodium vivax importin-beta 2, putative 0.0029 0.0269 0.455
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0872 0.1028
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0484 0.0571
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0.0872 0.1666
Brugia malayi nuclear hormone receptor 0.0008 0.001 0.0034
Trichomonas vaginalis inositol monophosphatase, putative 0.007 0.0762 0.253
Leishmania major hypothetical protein, conserved 0.0025 0.0213 0.2802
Echinococcus multilocularis g-protein coupled receptor 0.0079 0.0872 0.0916
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0122 0.0144
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0188 0.0624
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0021 0.0172 0.0329
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0872 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0122 0.0405
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0023 0.0188 0.0188
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0144 0.048
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0233 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0354 0.1175
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0023 0.0188 0.0197
Brugia malayi Dopamine receptor protein 2 0.0079 0.0872 0.2896
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3011 1
Leishmania major hydrolase-like protein 0.0023 0.0188 0.2466
Echinococcus multilocularis smad 0.0008 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0122 0.0405
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.172 0.2028
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0122 0.0128
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0144 0.0144
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0563 0.0592
Schistosoma mansoni neuropeptide receptor 0.0079 0.0872 0.1028
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0872 0.1028
Treponema pallidum phosphoglycolate phosphatase 0.0021 0.0172 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0354 0.7212
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0122 0.0627
Brugia malayi G-protein coupled receptor 0.0079 0.0872 0.2896
Schistosoma mansoni smad 0.0008 0.0008 0.0009
Schistosoma mansoni amine GPCR 0.0079 0.0872 0.1028
Onchocerca volvulus 0.0079 0.0872 0.4483
Schistosoma mansoni opsin-like receptor 0.0079 0.0872 0.1028
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.007 0.0762 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0563 0.0664
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0.0872 0.1028
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0122 0.0144
Echinococcus granulosus hypothetical protein 0.0294 0.3506 0.4134
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0.0872 0.1028
Brugia malayi hypothetical protein 0.0009 0.0022 0.0074
Loa Loa (eye worm) TYRA-2 protein 0.0079 0.0872 0.1666
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0108 0.0206
Schistosoma mansoni hypothetical protein 0.0065 0.0709 0.0835
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0122 0.0128
Onchocerca volvulus 0.0079 0.0872 0.4483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0709 0.2353
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.4821 0.5065
Brugia malayi neuropeptide F receptor 0.0079 0.0872 0.2896
Onchocerca volvulus 0.0023 0.0196 0.1007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0144 0.048
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0.0872 0.1028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.007 0.0762 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0144 0.1896
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0.0872 0.2896
Plasmodium falciparum epoxide hydrolase 1 0.0023 0.0188 0.2332
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Schistosoma mansoni amine GPCR 0.0079 0.0872 0.1028
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0122 0.0233
Mycobacterium ulcerans epoxide hydrolase EphE 0.0023 0.0188 0.0188
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0174 0.0579
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0872 0.0916
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Loa Loa (eye worm) DR-78 0.0008 0.001 0.002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0.0872 0.1028
Mycobacterium ulcerans hypothetical protein 0.0023 0.0188 0.0188
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0172 0.0329
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Leishmania major GTP-binding protein, putative 0.0022 0.0174 0.229
Echinococcus granulosus g-protein coupled receptor 0.0079 0.0872 0.1028
Schistosoma mansoni nuclear receptor 0.0008 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0402 0.4821 0.5684
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0023 0.0188 0.2466
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0122 0.0233
Giardia lamblia Phosphoglycolate phosphatase 0.0021 0.0172 0.4314
Mycobacterium ulcerans oxidoreductase 0.0023 0.0188 0.0188
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0008 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0144 0.1896
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0021 0.0172 0.0172
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0023 0.0188 0.2466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0236
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0083 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0196
Schistosoma mansoni lamin 0.0026 0.0233 0.0275
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Echinococcus granulosus microtubule associated protein 2 0.0701 0.8481 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Leishmania major hypothetical protein, conserved 0.0036 0.0354 0.4646
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0043
Onchocerca volvulus 0.0079 0.0872 0.4483
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0196
Onchocerca volvulus 0.0047 0.0484 0.2489
Onchocerca volvulus 0.0036 0.0354 0.1819
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0.0872 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Schistosoma mansoni ran 0.0022 0.0174 0.0206
Mycobacterium tuberculosis Conserved protein 0.0036 0.0354 0.0354
Schistosoma mansoni coup transcription factor 0.0017 0.0122 0.0144
Mycobacterium ulcerans epoxide hydrolase EphF 0.0023 0.0188 0.0188
Brugia malayi Smad1 0.0008 0.0008 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0023 0.0188 0.0188
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0484 0.0571
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0563 0.0664
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0122 0.0144
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0021 0.0172 0.0446
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0354 0.0354
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0872 0.1666
Mycobacterium ulcerans lipase/esterase 0.0023 0.0188 0.0188
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0.0872 0.1028
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0122 0.0144
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0108 0.1412
Echinococcus granulosus fmrfamide receptor 0.0079 0.0872 0.1028
Schistosoma mansoni hypothetical protein 0.0141 0.1634 0.1927
Schistosoma mansoni beta-catenin 0.0095 0.1072 0.1264
Echinococcus granulosus G protein coupled receptor 139 0.0079 0.0872 0.1028
Leishmania major hydrolase-like protein,esterase-like protein 0.0023 0.0188 0.2466
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0337 0.0397
Leishmania major hypothetical protein, conserved 0.0023 0.0188 0.2466
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.001 0.0012
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0.0872 0.1028
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0484 0.0571
Giardia lamblia Hydrolase, putative 0.0021 0.0172 0.4314
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0.0872 0.0916
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0484 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0122 0.0405
Brugia malayi hypothetical protein 0.0008 0.001 0.0034
Onchocerca volvulus 0.0079 0.0872 0.4483
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0.0872 0.2896
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0.0872 0.1666
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0018
Brugia malayi steroid hormone receptor 0.0017 0.0122 0.0405
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0188 0.2466
Schistosoma mansoni hypothetical protein 0.0289 0.3443 0.406
Echinococcus granulosus lamin dm0 0.0026 0.0233 0.0275
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.001 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0608 0.7987
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0374
Mycobacterium tuberculosis Probable exported protease 0.0023 0.0188 0.0188
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0354 0.0354
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0144 0.1896
Mycobacterium ulcerans epoxide hydrolase EphA 0.0825 1 1
Trypanosoma cruzi hydrolase-like protein, putative 0.0023 0.0188 0.2466
Schistosoma mansoni hypothetical protein 0.0079 0.0872 0.1028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0233 0.0445
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0021 0.0172 0.0203
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0354 0.0354
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0.0872 0.1028
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3011 1
Echinococcus granulosus abhydrolase domain containing protein 3 0.0023 0.0188 0.0221
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0174 0.229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0122 0.0233
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Leishmania major hydrolase, alpha/beta fold family, putative 0.0023 0.0188 0.2466
Echinococcus multilocularis neuropeptide s receptor 0.0542 0.6533 0.6864
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0122 0.0128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0236
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0872 0.0916
Onchocerca volvulus 0.0079 0.0872 0.4483
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0023 0.0188 0.0359
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0172 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Brugia malayi Dopamine receptor protein 1 0.0079 0.0872 0.2896
Brugia malayi hypothetical protein 0.0008 0.001 0.0034
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.001 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0213 0.3264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0269 0.3531
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0236
Mycobacterium ulcerans hypothetical protein 0.0021 0.0172 0.0172
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0872 0.0916
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0188 0.2466
Schistosoma mansoni opsin-like receptor 0.0079 0.0872 0.1028
Onchocerca volvulus 0.0079 0.0872 0.4483
Brugia malayi ecdysteroid receptor 0.0017 0.0122 0.0405
Echinococcus multilocularis beta catenin 0.0095 0.1072 0.1126
Mycobacterium tuberculosis Possible phosphatase 0.0021 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus multilocularis serotonin receptor 0.0079 0.0872 0.0916
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0122 0.0405
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2054 0.6823
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0122 0.0405
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0.0872 0.1028
Brugia malayi nuclear receptor NHR-67 0.0008 0.001 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Mycobacterium ulcerans lipase/esterase 0.0023 0.0188 0.0188
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0.0872 0.0916
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0047 0.0049
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0062 0.0672 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.001 0.0012
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0269 0.3531
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.2432 0.4647
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0.0872 0.2896
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0484 0.0509
Echinococcus granulosus g protein coupled receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) inositol-1 0.007 0.0762 0.1456
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0023 0.0188 0.2466
Onchocerca volvulus 0.0021 0.0172 0.0884
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0.0872 0.0916
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2217 0.2329
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Onchocerca volvulus 0.0079 0.0872 0.4483
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0122 0.0144
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0213 0.2811
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0872 0.1028
Onchocerca volvulus 0.0079 0.0872 0.4483
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0115
Mycobacterium ulcerans haloalkane dehalogenase 0.0023 0.0188 0.0188
Schistosoma mansoni myosin xvIII 0.0079 0.0872 0.1028
Schistosoma mansoni cpg binding protein 0.003 0.0275 0.0325
Brugia malayi hypothetical protein 0.0009 0.0022 0.0074
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0174 0.1843
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0.0872 0.1666
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis geminin 0.0331 0.3955 0.4155
Echinococcus granulosus neuropeptide s receptor 0.0542 0.6533 0.7703
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0108 0.0206
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0.0872 0.0916
Echinococcus granulosus neuropeptide receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0063 0.0687 0.0722
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0872 0.0916
Echinococcus granulosus dnaJ subfamily B 0.0402 0.4821 0.5684
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0354 0.0417
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0021 0.0172 0.0203
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0023 0.0188 0.2793
Onchocerca volvulus 0.0079 0.0872 0.4483
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0354 0.0417
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0172 0.2257
Schistosoma mansoni choline dehydrogenase 0.0021 0.0172 0.0203
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0122 0.0144
Onchocerca volvulus 0.0017 0.0122 0.0627
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Loa Loa (eye worm) hypothetical protein 0.0053 0.0563 0.1077
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0174 0.229
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.9517 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0023 0.0188 0.0188
Toxoplasma gondii ABC1 family protein 0.0036 0.0354 0.4646
Schistosoma mansoni lamin 0.0026 0.0233 0.0275
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.001 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0709 0.0835
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0563 0.0592
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0.0872 0.2896
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0196 0.257
Schistosoma mansoni inositol monophosphatase 0.007 0.0762 0.0898
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Mycobacterium ulcerans peroxidase BpoB 0.0023 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.001 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0122 0.0405
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0008 0.0008
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0872 0.0916
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0331 0.3955 0.4663
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.065
Echinococcus multilocularis cpg binding protein 0.003 0.0275 0.0289
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Onchocerca volvulus 0.0026 0.0233 0.1198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0122 0.0233
Echinococcus granulosus geminin 0.0331 0.3955 0.4663
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Brugia malayi neuropeptide F receptor 0.0079 0.0872 0.2896
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Brugia malayi mbt repeat family protein 0.0047 0.0484 0.1608
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0021 0.0172 0.2257
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0063 0.0687 0.081
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0122 0.0128
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0709 0.2353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0374
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0122 0.0144
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0443 0.1471
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0484 0.0509
Mycobacterium leprae Probable exported protease 0.0023 0.0188 0.2793
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0023 0.0188 0.2793
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0108 0.0206
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0122 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0008 0.0015
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0066 0.007
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0023 0.0188 0.0188
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0872 0.1666
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0021 0.0172 0.2257
Brugia malayi MH1 domain containing protein 0.0008 0.0008 0.0027
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0023 0.0188 0.2466
Mycobacterium ulcerans proline iminopeptidase PIP 0.0023 0.0188 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0022 0.0043
Brugia malayi alpha/beta hydrolase 0.0023 0.0188 0.0624
Trypanosoma cruzi glycosyl hydrolase, putative 0.0021 0.0172 0.2257
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Schistosoma mansoni hydrolase 0.0023 0.0188 0.0221
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0095 0.1072 0.3559
Mycobacterium ulcerans hypothetical protein 0.0036 0.0354 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0122 0.0405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0196 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.065
Echinococcus granulosus smad 0.0008 0.0008 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0122 0.0144
Echinococcus granulosus Smad4 0.0008 0.0008 0.0009
Echinococcus granulosus abhydrolase domain containing protein 0.0023 0.0188 0.0221
Loa Loa (eye worm) hypothetical protein 0.0047 0.0484 0.0925
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0021 0.0172 0.0181
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0443 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0043
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0023 0.0188 0.2466
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0354 0.1175
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.3011 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1945 1
Mycobacterium ulcerans hydrolase 0.0023 0.0188 0.0188
Onchocerca volvulus 0.0008 0.001 0.0053
Entamoeba histolytica myo-inositol monophosphatase, putative 0.007 0.0762 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0213 0.2802
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0023 0.0188 0.0221
Echinococcus multilocularis orexin receptor type 2 0.0079 0.0872 0.0916
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0408
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.001 0.0034
Schistosoma mansoni adenoreceptor 0.0079 0.0872 0.1028
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus cpg binding protein 0.003 0.0275 0.0325
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0021
Brugia malayi MH2 domain containing protein 0.0008 0.0008 0.0027
Brugia malayi Dopamine receptor 0.0079 0.0872 0.2896
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0174 0.229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0122 0.0144
Schistosoma mansoni neuropeptide receptor 0.0079 0.0872 0.1028
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Mycobacterium ulcerans lignin peroxidase LipJ 0.0023 0.0188 0.0188
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Mycobacterium ulcerans hypothetical protein 0.0023 0.0188 0.0188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0122 0.0233
Brugia malayi Nuclear hormone receptor E75 0.0008 0.001 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0484 0.0571
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0021 0.0172 0.0329
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0.0872 0.2896
Brugia malayi HMG box family protein 0.0063 0.0687 0.2281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0354 0.0417
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.257
Brugia malayi beta-lactamase family protein 0.0036 0.0354 0.1175
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0023 0.0188 0.0624
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0047 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0122 0.0405
Onchocerca volvulus 0.0036 0.0354 0.1819
Schistosoma mansoni hypothetical protein 0.0065 0.0709 0.0835
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0065 0.0709 0.1354
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0172 0.2257
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0188 0.0624
Loa Loa (eye worm) hypothetical protein 0.0435 0.5233 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0709 0.0744
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2217 0.2614
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0122 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0122 0.0405
Onchocerca volvulus 0.0079 0.0872 0.4483
Mycobacterium ulcerans hypothetical protein 0.0023 0.0196 0.0196
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0021 0.0172 0.151
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0023 0.0188 0.2466
Schistosoma mansoni amine GPCR 0.0079 0.0872 0.1028
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0144 0.0276
Echinococcus granulosus hypothetical protein 0.0079 0.0872 0.1028
Schistosoma mansoni hypothetical protein 0.0065 0.0709 0.0835
Brugia malayi G protein-coupled receptor 0.0079 0.0872 0.2896
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0174 0.4376
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0443 0.0522
Mycobacterium ulcerans exported protease 0.0023 0.0188 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0112 0.0112
Brugia malayi hydrolase, alpha/beta fold family protein 0.0023 0.0188 0.0624
Entamoeba histolytica hypothetical protein 0.0023 0.0188 0.2466
Echinococcus multilocularis sex peptide receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0009
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0.0872 0.2896
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0269 0.3531
Brugia malayi Cytochrome P450 family protein 0.0016 0.0108 0.0357
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0023 0.0188 0.0221
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0872 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0122 0.0405
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.001 0.0053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0872 0.0916
Entamoeba histolytica hypothetical protein 0.0021 0.0172 0.2257
Echinococcus multilocularis snurportin 1 0.0313 0.3734 0.3923
Onchocerca volvulus Lipase homolog 0.0023 0.0188 0.0966
Echinococcus granulosus beta catenin 0.0095 0.1072 0.1264
Schistosoma mansoni hypothetical protein 0.0035 0.0337 0.0397
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0083 0.0277
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0009
Echinococcus granulosus sex peptide receptor 0.0079 0.0872 0.1028
Leishmania major hypothetical protein, conserved 0.0023 0.0188 0.2466
Entamoeba histolytica hypothetical protein 0.0035 0.0337 0.4425
Mycobacterium tuberculosis Probable hydrolase 0.0021 0.0172 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0122 0.0405
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Brugia malayi G-protein coupled receptor 0.0079 0.0872 0.2896
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.3011 0.5754
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0122 0.0128
Schistosoma mansoni ap endonuclease 0.0019 0.0144 0.017
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0872 0.0916
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0.0872 0.1028
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0124 0.0124
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0201 0.2642
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0174 0.0206
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0008 0.0015
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0108 0.0108
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0.0872 0.1028
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0188 0.0188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0872 0.1028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0122 0.0144
Brugia malayi nuclear hormone receptor 0.0017 0.0122 0.0405
Entamoeba histolytica hypothetical protein 0.0035 0.0337 0.4425
Brugia malayi RNA, U transporter 1 0.0083 0.0929 0.3086
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0174 0.1587
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0642 0.0757
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Brugia malayi nuclear receptor NHR-88 0.0008 0.001 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0008 0.001 0.0012
Trichomonas vaginalis hydrolase, putative 0.0023 0.0188 0.0624
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Mycobacterium leprae Probable hydrolase 0.0021 0.0172 0.2556
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0172 0.0571
Schistosoma mansoni importin beta-1 0.0029 0.0269 0.0317
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0115
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0354 0.0676
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Schistosoma mansoni cpg binding protein 0.003 0.0275 0.0325
Onchocerca volvulus 0.0079 0.0872 0.4483
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.001 0.002
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0023 0.0188 0.2793
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0872 0.1028
Brugia malayi conserved hypotetical protein 0.0008 0.001 0.0034
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Echinococcus granulosus allatostatin A receptor 0.0079 0.0872 0.1028
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.001 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1669 0.1968
Brugia malayi ORL1-like opioid receptor 0.0079 0.0872 0.2896
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0017 0.0033
Trypanosoma cruzi hydrolase-like protein, putative 0.0023 0.0188 0.2466
Echinococcus granulosus inositol monophosphatase 1 0.007 0.0762 0.0898
Echinococcus granulosus importin subunit beta 1 0.0029 0.0269 0.0317
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.172 0.5712
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0398 0.5232
Brugia malayi beta-lactamase 0.0036 0.0354 0.1175
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.001 0.002
Brugia malayi follicle stimulating hormone receptor 0.0079 0.0872 0.2896
Echinococcus multilocularis lamin 0.0026 0.0233 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0.0872 0.0916
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0872 0.1028
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0196 0.0196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.2432 0.8077
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0.0872 0.0916
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0872 0.1028
Schistosoma mansoni amine GPCR 0.0079 0.0872 0.1028
Mycobacterium ulcerans hydrolase 0.0021 0.0172 0.0172
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0021 0.0172 0.2257
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Schistosoma mansoni intermediate filament proteins 0.0026 0.0233 0.0275
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0122 0.0128
Entamoeba histolytica Ran family GTPase 0.0022 0.0174 0.229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0354 0.0676
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.172 0.1807
Loa Loa (eye worm) hypothetical protein 0.0206 0.2432 0.4647
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0144 0.1896
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.007 0.0762 1
Schistosoma mansoni biogenic amine receptor 0.0079 0.0872 0.1028
Trichomonas vaginalis esterase, putative 0.0036 0.0354 0.1175
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0.0872 0.0916
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0.0872 0.0916
Brugia malayi Importin beta-1 subunit 0.0029 0.0269 0.0893
Schistosoma mansoni biogenic amine receptor 0.0079 0.0872 0.1028
Brugia malayi MH2 domain containing protein 0.0008 0.0008 0.0027
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0023 0.0188 0.0359
Mycobacterium leprae Probable lipase LipE 0.0036 0.0354 0.5262
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0709 0.0835
Entamoeba histolytica hypothetical protein 0.0035 0.0337 0.4425
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0.0872 0.0916
Echinococcus multilocularis lamin dm0 0.0026 0.0233 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0354 0.4646
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0872 0.1666
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0354 0.0372
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.001 0.0011
Loa Loa (eye worm) MBCTL1 0.0053 0.0563 0.1077
Leishmania major cytochrome p450-like protein 0.0016 0.0108 0.1412
Schistosoma mansoni Smad4 0.0008 0.0008 0.0009
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0172 0.2257
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0023 0.0188 0.0197
Onchocerca volvulus 0.0079 0.0872 0.4483
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0144 0.0152
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0023 0.0188 0.2793
Brugia malayi nuclear receptor NHR-88 0.0017 0.0122 0.0405
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0108 0.1412
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Mycobacterium ulcerans epoxide hydrolase EphB 0.0023 0.0188 0.0188
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0008 0.0008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0174 0.0333
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.001 0.0034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.007 0.0762 0.253
Loa Loa (eye worm) Smad1 0.0008 0.0008 0.0015
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0354 0.1175
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0023 0.0188 0.0197
Echinococcus multilocularis inositol monophosphatase 1 0.007 0.0762 0.08
Mycobacterium ulcerans hypothetical protein 0.0023 0.0188 0.0188
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0023 0.0188 0.2466
Echinococcus granulosus GPCR family 2 0.0065 0.0709 0.0835
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0.0872 0.1028
Echinococcus granulosus orexin receptor type 2 0.0079 0.0872 0.1028
Brugia malayi larval opioid receptor 0.0079 0.0872 0.2896
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0036 0.0354 0.0676
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0008 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3011 1
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0172 0.0571
Echinococcus multilocularis musashi 0.0026 0.0233 0.0245
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0144 0.3624
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0872 0.1028
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0172 0.2257
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0872 0.1028
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0188 0.0624
Schistosoma mansoni biogenic amine receptor 0.0079 0.0872 0.1028
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0023 0.0188 0.0188
Mycobacterium ulcerans bromoperoxidase BpoC 0.0023 0.0188 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0354 0.1175
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni neuropeptide receptor 0.0079 0.0872 0.1028
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0122 0.0405
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0236
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.001 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0112 0.0112
Mycobacterium tuberculosis Conserved protein 0.0036 0.0354 0.0354
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0172 0.2257
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0124 0.0124
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0872 0.1028
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Brugia malayi beta-lactamase family protein 0.0036 0.0354 0.1175
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.007 0.0762 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0022 0.0023
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0023 0.0188 0.2332
Loa Loa (eye worm) beta-lactamase 0.0036 0.0354 0.0676
Schistosoma mansoni zinc finger protein 0.0008 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0122 0.0405
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0398 1
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0023 0.0188 0.0197
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0443 0.5814
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Mycobacterium ulcerans hydrolase 0.0021 0.0172 0.0172
Echinococcus granulosus pangolin 0.0063 0.0687 0.081
Plasmodium vivax alpha/beta hydrolase, putative 0.0023 0.0188 0.2008
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0872 0.0916
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0872 0.0916
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0174 0.229
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0213 0.2802
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0196 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0144 0.048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni histamine h1 receptor 0.0079 0.0872 0.1028
Mycobacterium ulcerans hypothetical protein 0.0023 0.0188 0.0188
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0188 0.2008
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0043
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0354 0.0354
Brugia malayi putative neuropeptide receptor 0.0079 0.0872 0.2896
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0196
Mycobacterium tuberculosis Conserved protein 0.0023 0.0188 0.0188
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0008 0.0009
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0023 0.0188 0.2466
Schistosoma mansoni hypothetical protein 0.0079 0.0872 0.1028
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0.0872 0.0916
Brugia malayi tailless protein 0.0008 0.001 0.0034
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0872 0.1028
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0023 0.0188 0.0188
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0.0872 0.1028
Brugia malayi nuclear receptor RXR 0.0009 0.0022 0.0074
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0354 0.0354
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0.0872 0.0916
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0872 0.1028
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Onchocerca volvulus 0.0008 0.001 0.0053
Brugia malayi nuclear receptor RXR 0.0008 0.001 0.0034
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0201 0.0668
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0172 0.0571
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2054 0.6823
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0023 0.0188 0.0197
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0174 0.0183
Schistosoma mansoni hypothetical protein 0.0065 0.0709 0.0835
Brugia malayi hypothetical protein 0.0035 0.0337 0.1119
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0122 0.0144
Onchocerca volvulus 0.0079 0.0872 0.4483
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0172 0.0172
Onchocerca volvulus Lipase homolog 0.0023 0.0188 0.0966
Echinococcus granulosus abhydrolase domain containing protein 11 0.0023 0.0188 0.0221
Onchocerca volvulus 0.0079 0.0872 0.4483
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0.0872 0.1666
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0122 0.0405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0122 0.0233
Schistosoma mansoni amine GPCR 0.0079 0.0872 0.1028
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0022 0.0074
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0.0872 0.2896
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0023 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0188 0.0359
Echinococcus granulosus intermediate filament protein 0.0026 0.0233 0.0275
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0709 0.1354
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0021 0.0172 0.0203
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0188 0.0624
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.007 0.0762 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Echinococcus multilocularis allatostatin A receptor 0.0079 0.0872 0.0916
Schistosoma mansoni ap endonuclease 0.0019 0.0144 0.017
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus lamin 0.0026 0.0233 0.0275
Echinococcus granulosus snurportin 1 0.0313 0.3734 0.4402
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0563 0.1871
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0122 0.0144
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0354 0.1175
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0.0872 0.1028
Brugia malayi intermediate filament protein 0.0026 0.0233 0.0774
Echinococcus granulosus g protein coupled receptor 0.0079 0.0872 0.1028
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0872 0.0916
Brugia malayi MH1 domain containing protein 0.0008 0.0008 0.0027
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0354 0.0354
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0023 0.0188 0.0188
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0144 0.017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0144 0.1896
Onchocerca volvulus 0.0028 0.0256 0.1314
Schistosoma mansoni nuclear receptor 0.0008 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0022 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0233 0.0445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.0445
Mycobacterium ulcerans haloalkane dehalogenase 0.0023 0.0188 0.0188
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0122 0.0144
Echinococcus multilocularis abhydrolase domain containing protein 0.0023 0.0188 0.0197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0022 0.0026
Plasmodium falciparum importin beta, putative 0.0029 0.0269 0.5284
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0122 0.0144
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0313 0.3734 0.4402
Brugia malayi mbt repeat family protein 0.0047 0.0484 0.1608
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0484 0.2489
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0354 0.0354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0872 0.1028
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0872 0.1028
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0188 0.2008
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.007 0.0762 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0066 0.0078
Mycobacterium ulcerans hypothetical protein 0.0021 0.0172 0.0172
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0443 0.5814
Onchocerca volvulus 0.0021 0.0172 0.0884
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.002
Mycobacterium ulcerans beta-lactamase 0.0036 0.0354 0.0354
Schistosoma mansoni ran 0.0022 0.0174 0.0206
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Echinococcus granulosus somatostatin receptor 0.0079 0.0872 0.1028
Entamoeba histolytica hypothetical protein 0.0035 0.0337 0.4425
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0201 0.0668
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0374
Trichomonas vaginalis ran, putative 0.0022 0.0174 0.0579
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0124 0.7198
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0122 0.0627
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Schistosoma mansoni neuropeptide receptor 0.0079 0.0872 0.1028
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0023 0.0188 0.0188
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0196 0.257
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0021 0.0172 0.0181
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0196 0.2911
Mycobacterium ulcerans exported protease 0.0023 0.0188 0.0188
Echinococcus granulosus neuropeptide receptor 0.0079 0.0872 0.1028
Echinococcus multilocularis somatostatin receptor 0.0079 0.0872 0.0916
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0127
Echinococcus multilocularis abhydrolase domain containing 3 0.0023 0.0188 0.0197
Mycobacterium tuberculosis Conserved protein 0.0036 0.0354 0.0354
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0122 0.0128
Treponema pallidum phosphoglycolate phosphatase 0.0021 0.0172 1
Echinococcus multilocularis GPCR, family 2 0.0065 0.0709 0.0744
Echinococcus granulosus neuropeptide receptor A26 0.0542 0.6533 0.7703
Schistosoma mansoni inositol monophosphatase 0.007 0.0762 0.0898
Brugia malayi ecdysone receptor 0.0008 0.001 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.065
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0023 0.0188 0.0188
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0172 0.2257
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0172 0.2257
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0011 0.0047 0.0055
Echinococcus granulosus g protein coupled receptor 0.0079 0.0872 0.1028
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Brugia malayi AKH receptor 0.0079 0.0872 0.2896
Loa Loa (eye worm) hypothetical protein 0.0017 0.0122 0.0233
Leishmania major importin beta-1 subunit, putative 0.0024 0.0201 0.2642
Onchocerca volvulus 0.0079 0.0872 0.4483
Entamoeba histolytica hypothetical protein 0.0021 0.0172 0.2257
Brugia malayi UPF0017 protein CG3488 0.0023 0.0188 0.0624
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0213 0.3264
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0021 0.0172 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0172 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0122 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1337 0.2555
Loa Loa (eye worm) hypothetical protein 0.0036 0.0354 0.0676
Brugia malayi hydrolase, alpha/beta fold family protein 0.0023 0.0188 0.0624
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0872 0.1028
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0172 0.0571
Schistosoma mansoni opsin-like receptor 0.0079 0.0872 0.1028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0122 0.0233
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0.0872 0.4483
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0213 0.2802
Toxoplasma gondii alpha/beta hydrolase, putative 0.0023 0.0188 0.2466
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0.0872 0.1028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0122 0.0128
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0563 0.0664
Loa Loa (eye worm) acetyltransferase 0.0148 0.172 0.3287
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.1634 0.5428
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0021 0.0172 0.1753
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0.0872 0.1028
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0872 0.1028
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0021 0.0172 0.0571
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0188 0.0624
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.001 0.0012
Brugia malayi MH2 domain containing protein 0.0117 0.1337 0.4441
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0122 0.0144
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0023 0.0188 0.0966
Brugia malayi GnHR receptor homolog 0.0079 0.0872 0.2896
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0144 0.1896
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0872 0.0916
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.8481 1
Schistosoma mansoni hypothetical protein 0.0231 0.2737 0.3227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0872 0.0916
Brugia malayi sulfakinin receptor protein 0.0079 0.0872 0.2896
Onchocerca volvulus 0.0079 0.0872 0.4483
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.2432 0.8077
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0.0872 0.1666
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1945 0.6459
Giardia lamblia ENC6 protein 0.0023 0.0188 0.4713
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0354 0.0676
Brugia malayi Serotonin receptor 0.0079 0.0872 0.2896
Brugia malayi hypothetical protein 0.0079 0.0872 0.2896
Loa Loa (eye worm) HMG box family protein 0.0063 0.0687 0.1313
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0122 0.0128
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0227 0.0434
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0236
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0256 0.0488
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0201 0.0668
Loa Loa (eye worm) hypothetical protein 0.0023 0.0188 0.0359
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.001 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0354 0.4646
Loa Loa (eye worm) hypothetical protein 0.0079 0.0872 0.1666
Leishmania major hydrolase-like protein,esterase-like protein 0.0023 0.0188 0.2466
Brugia malayi CXXC zinc finger family protein 0.0028 0.0256 0.0849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0122 0.0233
Loa Loa (eye worm) hypothetical protein 0.0029 0.0269 0.0514
Onchocerca volvulus 0.0036 0.0354 0.1819
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0269 0.0283
Trichomonas vaginalis myo inositol monophosphatase, putative 0.007 0.0762 0.253
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0.0872 0.1666
Echinococcus multilocularis serotonin receptor 0.0079 0.0872 0.0916
Chlamydia trachomatis phosphoglycolate phosphatase 0.0021 0.0172 1
Schistosoma mansoni cpg binding protein 0.0028 0.0256 0.0301
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0043
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0443 0.1471
Loa Loa (eye worm) hypothetical protein 0.0435 0.5233 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0122 0.0144
Brugia malayi Inositol-1 0.007 0.0762 0.253
Mycobacterium ulcerans lipase LipD 0.0036 0.0354 0.0354
Loa Loa (eye worm) HMP-2 protein 0.0095 0.1072 0.2048
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0188 0.2008
Mycobacterium leprae Probable exported protease 0.0023 0.0188 0.2793
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0144 0.0752
Brugia malayi hypothetical protein 0.0025 0.0213 0.0709
Echinococcus granulosus serotonin receptor 0.0079 0.0872 0.1028
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0021 0.0172 0.4314

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation at 3.6 mM ChEMBL. 17566735
Activity (binding) 0 Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation at 3.6 mM ChEMBL. 17566735
IC50 (binding) = 2.8 mM Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation ChEMBL. 17566735
IC50 (binding) = 2.8 mM Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation ChEMBL. 17566735
MIC (functional) = 8 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Ra ChEMBL. 17566735
MIC (functional) = 8 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Ra ChEMBL. 17566735
MIC (functional) = 16 ug ml-1 Antimycobacterial activity against Mycobacterium avium ChEMBL. 17566735

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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