Detailed information for compound 546271

Basic information

Technical information
  • TDR Targets ID: 546271
  • Name: 2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one
  • MW: 186.21 | Formula: C11H10N2O
  • H donors: 2 H acceptors: 1 LogP: 1.69 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCCc2c1[nH]c1c2cccc1
  • InChi: 1S/C11H10N2O/c14-11-10-8(5-6-12-11)7-3-1-2-4-9(7)13-10/h1-4,13H,5-6H2,(H,12,14)
  • InChiKey: FZHZQHNKCPJTNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3,4,9-tetrahydro-$b-carbolin-1-one
  • 17952-82-8
  • 2,3,4,9-Tetrahydro-1H-pyrido(3,4-b)indol-1-one
  • Oprea1_215891
  • MLS000766137
  • ZINC00054469
  • 1,2,3,4-Tetrahydrol-oxo-beta-carboline
  • SMR000122646
  • MLS001049054
  • EINECS 241-878-7
  • Oprea1_286796
  • MLS000523573
  • 1,2,3,4-Tetrahydro-1-oxo-.beta.-carboline
  • 1,2,3,4-Tetrahydronorharman-1-one
  • 1H-Pyrido[3,4-b]indol-1-one, 2,3,4,9-tetrahydro-
  • L-Oxonoreleagnine
  • NSC147829
  • ZERO/001846
  • 2,3,4,9-Tetrahydro-beta-carbolin-1-one
  • BAS 02786828

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0036 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.1259 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0336 0.4321
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0457 0.6008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.3375 0.3396
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0458 0.091
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0088 0.0177
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0071 0.0106
Brugia malayi hypothetical protein 0.0022 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0072 0.0457 0.046
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0108 0.0744 0.0749
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0925 0.189
Schistosoma mansoni cpg binding protein 0.0126 0.0894 0.0894
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0095 0.0145
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0031 0.0031
Schistosoma mansoni rab6-interacting 0.0022 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0088 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0088 0.0089
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0458 0.0458
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0108 0.0744 0.0744
Echinococcus multilocularis zinc finger protein 0.1143 0.9072 0.9072
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0078 0.073
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0056 0.0056
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0087 0.0574 0.324
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.5258 0.5258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0458 0.6023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0457 0.0908
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0925 0.1813
Loa Loa (eye worm) MBOAT family protein 0.0108 0.0744 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0088 0.0089
Brugia malayi nuclear hormone receptor 0.0026 0.0088 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1348 0.1348
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0088 0.0089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0021 0.0021
Echinococcus multilocularis enteropeptidase 0.0018 0.0021 0.0021
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0056 0.0415
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0088 0.0088
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0108 0.0744 0.0744
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0087 0.0574 1
Brugia malayi Trypsin family protein 0.0018 0.0021 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0256 0.1935 0.1935
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0088 0.0088
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0179 0.0179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1348 0.1348
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0457 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0087 0.0574 0.1068
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0457 0.6008
Loa Loa (eye worm) hypothetical protein 0.0108 0.0744 0.0749
Mycobacterium ulcerans hypothetical protein 0.061 0.478 1
Toxoplasma gondii ABC1 family protein 0.0072 0.0457 0.2551
Onchocerca volvulus 0.005 0.0277 0.0669
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0095 0.0145
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0734 0.0734
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0457 0.0908
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0179 0.0322
Brugia malayi Trypsin family protein 0.0018 0.0021 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0457 0.0908
Onchocerca volvulus 0.0072 0.0457 0.1139
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0056 0.0056
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0056 0.0056
Toxoplasma gondii thioredoxin reductase 0.0057 0.0336 0.1835
Leishmania major glycerol uptake protein, putative 0.0108 0.0744 1
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0088 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0457 0.046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1042 0.2061
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0031 0.001
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0071 0.082
Brugia malayi beta-lactamase family protein 0.0072 0.0457 0.046
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0071 0.0266
Echinococcus granulosus enteropeptidase 0.0018 0.0021 0.0021
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0458 0.6023
Echinococcus multilocularis RUN 0.0022 0.0056 0.0056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0036 0.0142
Leishmania major glycerol uptake protein, putative 0.0108 0.0744 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0244 0.1837 0.1837
Brugia malayi Pre-SET motif family protein 0.0435 0.3375 0.3396
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0193 0.0193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0088 0.0088
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0036 0.0142
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0457 0.0908
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.0134 0.0134
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0088 0.0177
Brugia malayi MH2 domain containing protein 0.0129 0.0916 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0088 0.0089
Echinococcus granulosus zinc finger protein 0.1143 0.9072 0.9072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0036 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0036 0.0142
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0036 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0088 0.0089
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0734 0.0734
Mycobacterium ulcerans beta-lactamase 0.0072 0.0457 0.0918
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0087 0.0574 0.1153
Loa Loa (eye worm) hypothetical protein 0.0072 0.0458 0.0461
Echinococcus multilocularis Mastin 0.0018 0.0021 0.0021
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0179 0.2131
Toxoplasma gondii hypothetical protein 0.0108 0.0744 0.4246
Onchocerca volvulus Huntingtin homolog 0.0148 0.1067 0.2728
Loa Loa (eye worm) hypothetical protein 0.0108 0.0744 0.0749
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0071 0.0626
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0266 0.0267
Plasmodium vivax glutathione reductase, putative 0.0057 0.0336 0.4321
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0056 0.0415
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0108 0.0744 0.0744
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.1348 0.1356
Brugia malayi follicle stimulating hormone receptor 0.1169 0.9281 0.9339
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0457 0.0908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0095 0.0145
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0734 0.0734
Loa Loa (eye worm) hhat protein 0.0108 0.0744 0.0749
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1348 0.1348
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0021
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0566 0.0566
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0457 0.6008
Loa Loa (eye worm) inositol-1 0.0038 0.0179 0.018
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.061 0.478 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1042 0.2136
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0193 0.0193
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0336 0.0336
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0131 0.0132
Loa Loa (eye worm) hypothetical protein 0.0065 0.0397 0.0399
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0087 0.0574 0.1153
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0916 0.0921
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0458 0.6023
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0378 0.0378
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0457 0.0908
Brugia malayi MBOAT family protein 0.0108 0.0744 0.0749
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0088 0.0177
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0072 0.0457 0.046
Echinococcus granulosus Mastin 0.0018 0.0021 0.0021
Loa Loa (eye worm) MBOAT family protein 0.0108 0.0744 0.0749
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.061 0.478 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Schistosoma mansoni lipoxygenase 0.0062 0.0378 0.0378
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0108 0.0744 0.0744
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0071 0.0095
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0095 0.0145
Echinococcus granulosus cpg binding protein 0.0126 0.0894 0.0894
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0458 0.0458
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0088 0.0089
Schistosoma mansoni inositol monophosphatase 0.0038 0.0179 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0088 0.0089
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0457 0.0457
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0088 0.0088
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0108 0.0744 0.0744
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0018 0.0021 0.0021
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.061 0.478 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Echinococcus granulosus RUN 0.0022 0.0056 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0031 0.0068
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0056 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0088 0.0088
Leishmania major glycerol uptake protein, putative 0.0108 0.0744 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0095 0.0145
Schistosoma mansoni hypothetical protein 0.0022 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1169 0.9281 0.9339
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0088 0.0088
Onchocerca volvulus 0.0244 0.1837 0.4736
Mycobacterium ulcerans acetylornithine aminotransferase 0.0087 0.0574 0.1163
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0179 0.0905
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0108 0.0744 0.0744
Schistosoma mansoni cpg binding protein 0.012 0.0839 0.0839
Loa Loa (eye worm) trypsin family protein 0.0018 0.0021 0.0021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.0011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0179 0.2131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0088 0.0089
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0458 0.0458
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0087 0.0574 0.1163
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0088 0.0088
Schistosoma mansoni cpg binding protein 0.0126 0.0894 0.0894
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Echinococcus granulosus transmembrane protease serine 3 0.0018 0.0021 0.0021
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0036 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0095 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0088 0.0089
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0179 0.2131
Echinococcus multilocularis transmembrane protease serine 3 0.0018 0.0021 0.0021
Onchocerca volvulus 0.0495 0.3856 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0031 0.0068
Brugia malayi hypothetical protein 0.0022 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0108 0.0744 1
Brugia malayi hypothetical protein 0.0016 0.0007 0.0007
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0087 0.0574 0.1163
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0036 0.0142
Brugia malayi beta-lactamase family protein 0.0072 0.0457 0.046
Echinococcus multilocularis glycoprotein Antigen 5 0.0018 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0458 0.091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1348 0.1348
Onchocerca volvulus 0.0022 0.0056 0.0092
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0336 0.0653
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Plasmodium falciparum ornithine aminotransferase 0.0087 0.0574 0.7632
Schistosoma mansoni hypothetical protein 0.0033 0.0143 0.0143
Brugia malayi MBOAT family protein 0.1251 0.9939 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0108 0.0744 0.0744
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0108 0.0744 0.0744
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0397 0.0397
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0021 0.0021
Echinococcus granulosus o acyltransferase membrane bound domain 0.0108 0.0744 0.0744
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0036 0.0142
Trichomonas vaginalis transmembrane protein nessy, putative 0.0108 0.0744 0.1511
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0071 0.0266
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0457 0.0908
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0078 0.031
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.1251 0.9939 0.9939
Loa Loa (eye worm) hypothetical protein 0.0244 0.1837 0.1848
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0108 0.0744 0.0744
Giardia lamblia DINP protein human, muc B family 0.0019 0.0031 0.0113
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0378 0.0378
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0078 0.073
Echinococcus multilocularis muscleblind protein 0.1206 0.9579 0.9579
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0108 0.0744 0.0744
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0088 0.0089
Loa Loa (eye worm) hypothetical protein 0.0022 0.0056 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0244 0.1837 0.1848
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.6357 0.6357
Treponema pallidum alginate O-acetylation protein (algI) 0.0108 0.0744 1
Leishmania major hypothetical protein, conserved 0.0025 0.0078 0.073
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0036 0.0186
Trichomonas vaginalis porcupine, putative 0.0108 0.0744 0.1511
Echinococcus multilocularis Aminotransferase class III 0.0087 0.0574 0.0574
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0458 0.0458
Entamoeba histolytica hypothetical protein 0.0107 0.0734 0.9856
Brugia malayi Trypsin-like protease protein 5 0.0018 0.0021 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Loa Loa (eye worm) hypothetical protein 0.0148 0.1067 0.1074
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0566 0.057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0088 0.0089
Schistosoma mansoni DNA polymerase eta 0.0019 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0048 0.0266 0.0267
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0026
Loa Loa (eye worm) beta-lactamase 0.0072 0.0457 0.046
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.1838 0.1838
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0087 0.0574 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0458 0.0458
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0071 0.0626
Echinococcus multilocularis muscleblind protein 1 0.1206 0.9579 0.9579
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0336 0.0338
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0457 0.0908
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0088 0.0088
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0108 0.0744 0.4246
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0087 0.0574 0.1163
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0036 0.0142
Schistosoma mansoni rab6-interacting 0.0022 0.0056 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0088 0.0088
Onchocerca volvulus 0.0065 0.0397 0.0981
Schistosoma mansoni hypothetical protein 0.1259 1 1
Brugia malayi glutathione reductase 0.0057 0.0336 0.0338
Plasmodium vivax SET domain protein, putative 0.0065 0.0397 0.5164
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0108 0.0744 0.0744
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0088 0.0089
Trichomonas vaginalis esterase, putative 0.0072 0.0457 0.0908
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0036 0.0142
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Brugia malayi Hhat protein 0.0108 0.0744 0.0749
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0031 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0078 0.073
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0036 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0036 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0088 0.0089
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0088 0.0088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0244 0.1837 0.1837
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0078 0.073
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0036 0.0036
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0193 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0336 0.4321
Loa Loa (eye worm) glutathione reductase 0.0057 0.0336 0.0338
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0088 0.0089
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0036 0.0033
Mycobacterium ulcerans L-lysine aminotransferase 0.0087 0.0574 0.1163
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0036 0.0186
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0458 0.0458
Brugia malayi Doublecortin family protein 0.0022 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0397 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0031 0.001
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0458 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0088 0.0088
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0036 0.0142
Brugia malayi steroid hormone receptor 0.0026 0.0088 0.0089
Brugia malayi beta-lactamase 0.0072 0.0457 0.046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0088 0.0089
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0036 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0088 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.1348 0.1356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0095 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0036 0.0142
Brugia malayi Pre-SET motif family protein 0.0065 0.0397 0.0399
Loa Loa (eye worm) hypothetical protein 0.0072 0.0457 0.046
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0458 0.0458
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0397 0.0397
Plasmodium falciparum glutathione reductase 0.0057 0.0336 0.4321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0397 0.0397
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0457 0.0908
Mycobacterium tuberculosis Conserved protein 0.0072 0.0457 0.0908
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0031 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1348 0.1348
Leishmania major DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Schistosoma mansoni sterol O-acyltransferase 1 0.0108 0.0744 0.0744
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0266 0.0267
Entamoeba histolytica hypothetical protein 0.0107 0.0734 0.9856
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0071 0.0646
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0021 0.0021
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0179 0.0179
Leishmania major glycerol uptake protein, putative 0.0108 0.0744 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0457 0.0918
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0021 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0336 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0088 0.0089
Loa Loa (eye worm) hypothetical protein 0.0022 0.0056 0.0056
Brugia malayi hypothetical protein 0.0244 0.1838 0.1849
Trypanosoma cruzi glycerol uptake protein, putative 0.0108 0.0744 1
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0087 0.0574 0.1068
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0108 0.0744 0.0744
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0071 0.0626
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0744 0.1511
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0108 0.0744 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0357 0.0357
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0018 0.0021 0.0021
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0056 0.0056
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0108 0.0744 0.4246
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0071 0.0626
Brugia malayi Trypsin family protein 0.0018 0.0021 0.0021
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0397 0.0397
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0134 0.0134
Brugia malayi hypothetical protein 0.0025 0.0078 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0179 0.0322
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0031 0.0031
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0925 0.189
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0031 0.0068
Leishmania major glycerol uptake protein, putative 0.0108 0.0744 1
Loa Loa (eye worm) hhat protein 0.0108 0.0744 0.0749
Echinococcus granulosus muscleblind protein 0.1206 0.9579 0.9579
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0087 0.0574 0.1153
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0457 0.0918
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0179 0.0333
Mycobacterium tuberculosis Conserved protein 0.0072 0.0457 0.0908
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0087 0.0574 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0457 0.046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Onchocerca volvulus 0.0022 0.0056 0.0092
Brugia malayi Cytochrome P450 family protein 0.0032 0.0131 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0916 0.0921
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Loa Loa (eye worm) hypothetical protein 0.0072 0.0457 0.046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Onchocerca volvulus 0.012 0.0839 0.2133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.0134 0.0134
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0088 0.0088
Brugia malayi Muscleblind-like protein 0.1206 0.9579 0.9638
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0036 0.0142
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0458 0.091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0179 0.2131
Mycobacterium tuberculosis Probable reductase 0.013 0.0925 0.189
Entamoeba histolytica vacuolar protein sorting 26 0.0108 0.0744 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0744 0.1511
Trypanosoma brucei trypanothione reductase 0.0057 0.0336 0.4321
Loa Loa (eye worm) CXXC zinc finger family protein 0.012 0.0839 0.0844
Entamoeba histolytica hypothetical protein, conserved 0.0108 0.0744 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0179 0.2793
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0018 0.0021 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0078 0.073
Echinococcus granulosus glycoprotein Antigen 5 0.0018 0.0021 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0088 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0088 0.0088
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.1251 0.9939 0.9939
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0108 0.0744 0.0744
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0078 0.073
Brugia malayi MBOAT family protein 0.0108 0.0744 0.0749
Schistosoma mansoni inositol monophosphatase 0.0038 0.0179 0.0179
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0108 0.0744 0.0744
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0457 0.6008
Echinococcus granulosus dna polymerase kappa 0.0019 0.0031 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0457 0.0457
Loa Loa (eye worm) MBOAT family protein 0.1251 0.9939 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0108 0.0744 0.0744
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0031 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0457 0.0457
Echinococcus granulosus dna polymerase eta 0.0019 0.0031 0.0031
Plasmodium falciparum thioredoxin reductase 0.0057 0.0336 0.4321
Echinococcus granulosus Aminotransferase class III 0.0087 0.0574 0.0574
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0088 0.0088
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0189 0.019
Brugia malayi MBOAT family protein 0.0108 0.0744 0.0749
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0086 0.0566 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0143 0.0144
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0925 0.189
Loa Loa (eye worm) hypothetical protein 0.0244 0.1838 0.1849
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0458 0.0458
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0087 0.0574 0.0574
Brugia malayi hypothetical protein 0.0018 0.0021 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.5258 0.5258
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0108 0.0744 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0458 0.6023
Schistosoma mansoni zinc finger protein 0.1251 0.9939 0.9939
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0088 0.0089
Schistosoma mansoni hypothetical protein 0.0107 0.0734 0.0734
Schistosoma mansoni lipoxygenase 0.0022 0.0056 0.0056
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0566 0.0566
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0031 0.0068
Echinococcus multilocularis ornithine aminotransferase 0.0087 0.0574 0.0574
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0088 0.0088
Trypanosoma brucei unspecified product 0.0019 0.0031 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0088 0.0089
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0108 0.0744 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0229 0.1717 1
Brugia malayi MBOAT family protein 0.0108 0.0744 0.0749
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0087 0.0574 0.0578
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0021 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0088 0.0089
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0458 0.6023
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0088 0.0088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.3585 0.7487
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0925 0.189
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.061 0.478 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0108 0.0744 0.0744
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0566 0.0566
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0108 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.1206 0.9579 0.9638
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0457 0.0908
Leishmania major trypanothione reductase 0.0057 0.0336 0.4321
Echinococcus multilocularis cpg binding protein 0.0126 0.0894 0.0894
Onchocerca volvulus Huntingtin homolog 0.0148 0.1067 0.2728
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0036 0.0235
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0179 0.2131
Mycobacterium ulcerans lipase LipD 0.0072 0.0457 0.0918
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0108 0.0744 1
Trypanosoma brucei glycerol uptake protein, putative 0.0108 0.0744 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0036 0.0036
Onchocerca volvulus 0.0226 0.1693 0.4362
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0031 0.0031
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0088 0.0088
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0458 0.0461
Entamoeba histolytica hypothetical protein 0.0107 0.0734 0.9856
Brugia malayi ecdysteroid receptor 0.0026 0.0088 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0744 0.1511
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0147 0.0255
Schistosoma mansoni coup transcription factor 0.0026 0.0088 0.0088
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0108 0.0744 0.0744
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0457 0.0908
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0108 0.0744 1
Schistosoma mansoni loxhd1 0.0022 0.0056 0.0056
Echinococcus granulosus microtubule associated protein 2 0.0669 0.5258 0.5258
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0179 0.0322
Mycobacterium tuberculosis Conserved protein 0.0072 0.0457 0.0908
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0108 0.0744 0.0749
Onchocerca volvulus 0.0108 0.0744 0.1887
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0018 0.0021 0.0021
Trichomonas vaginalis helicase, putative 0.0027 0.0095 0.0145
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0026
Plasmodium falciparum glutathione reductase 0.002 0.0036 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Echinococcus granulosus o acyltransferase membrane bound domain 0.0108 0.0744 0.0744
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1042 0.2136
Loa Loa (eye worm) hypothetical protein 0.0108 0.0744 0.0749
Brugia malayi Trypsin family protein 0.0244 0.1837 0.1848
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0108 0.0744 0.0744
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.0068
Brugia malayi diacylglycerol acyltransferase 0.0108 0.0744 0.0749
Echinococcus granulosus sterol O acyltransferase 1 0.0108 0.0744 0.0744
Mycobacterium leprae Probable lipase LipE 0.0072 0.0457 0.0821
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0088 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1348 0.1348
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0457 0.046
Brugia malayi CXXC zinc finger family protein 0.012 0.0839 0.0844
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0925 0.189
Onchocerca volvulus 0.0026 0.0088 0.0177
Leishmania major hypothetical protein, conserved 0.0072 0.0457 0.6008
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0147 0.0162
Brugia malayi Thioredoxin reductase 0.0057 0.0336 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0088 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0088 0.0089
Onchocerca volvulus 0.0086 0.0566 0.1423
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0108 0.0744 1
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.1838 0.1838
Treponema pallidum NADH oxidase 0.002 0.0036 0.0142
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0266 0.0267
Schistosoma mansoni polycystin 1-related 0.0022 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0088 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0071 0.0626
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0108 0.0744 0.0749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1348 0.1348
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0022
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Trypanosoma cruzi glycerol uptake protein, putative 0.0108 0.0744 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0036 0.0142
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0018 0.0021 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0021 0.0021
Leishmania major DNA polymerase eta, putative 0.0019 0.0031 0.0068
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0397 0.2192
Loa Loa (eye worm) hypothetical protein 0.1206 0.9579 0.9638
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0087 0.0574 0.1153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Plasmodium vivax ornithine aminotransferase, putative 0.0087 0.0574 0.7632
Trichomonas vaginalis set domain proteins, putative 0.0495 0.3856 0.8056
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1042 0.2136
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Brugia malayi hypothetical protein 0.0107 0.0734 0.0738
Entamoeba histolytica hypothetical protein 0.0107 0.0734 0.9856
Trypanosoma cruzi GUP1, putative 0.0108 0.0744 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0108 0.0744 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0036 0.0036
Echinococcus multilocularis dna polymerase eta 0.0019 0.0031 0.0031
Plasmodium falciparum thioredoxin reductase 0.002 0.0036 0.0142
Brugia malayi Inositol-1 0.0038 0.0179 0.018
Mycobacterium tuberculosis Probable aminotransferase 0.061 0.478 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0277 0.0279
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0056 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0088 0.0088
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0036 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0068
Schistosoma mansoni hypothetical protein 0.005 0.0277 0.0277
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0071 0.0106
Schistosoma mansoni survival motor neuron protein 0.005 0.0277 0.0277
Mycobacterium ulcerans hypothetical protein 0.0072 0.0457 0.0918
Echinococcus granulosus ornithine aminotransferase 0.0087 0.0574 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0145
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0072 0.0457 0.046
Echinococcus multilocularis sterol O acyltransferase 1 0.0108 0.0744 0.0744
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0088 0.0088
Trypanosoma cruzi GUP1, putative 0.0108 0.0744 1
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0457 0.0821
Brugia malayi hypothetical protein 0.0148 0.1067 0.1074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0095 0.0145
Loa Loa (eye worm) hypothetical protein 0.0148 0.1067 0.1074
Brugia malayi nuclear receptor NHR-88 0.0026 0.0088 0.0089
Trypanosoma brucei glycerol uptake protein, putative 0.0108 0.0744 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0457 0.0457
Onchocerca volvulus 0.0072 0.0457 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0088 0.0089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0036 0.0142
Echinococcus multilocularis ornithine aminotransferase 0.0087 0.0574 0.0574
Entamoeba histolytica hypothetical protein 0.0024 0.0071 0.0626
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0087 0.0574 0.1163
Onchocerca volvulus 0.0072 0.0457 0.1139
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0036 0.0142
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0397 0.0397

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.818382931 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Activity (functional) Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 12828469
Activity (functional) Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 12828469
Activity (functional) Antileishmanial activity against Leishmania donovani promastigotes expressing luciferase ChEMBL. 12828469
IC50 (functional) > 40 uM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 22342628
IC50 (functional) > 40 uM Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay ChEMBL. 22342628
IC50 (functional) > 40 uM Cytotoxicity against human A549 cells after 48 hrs by MTT assay ChEMBL. 22342628
IC50 (functional) > 40 uM Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay ChEMBL. 22342628
IC50 (functional) > 40 uM Cytotoxicity against human SW480 cells after 48 hrs by MTT assay ChEMBL. 22342628
MIC (functional) Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ChEMBL. 12828469
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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