Detailed information for compound 546387

Basic information

Technical information
  • TDR Targets ID: 546387
  • Name: 1-anilino-3-[(4-chlorophenyl)carbamothioylami no]thiourea
  • MW: 351.877 | Formula: C14H14ClN5S2
  • H donors: 5 H acceptors: 0 LogP: 4.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NNc1ccccc1)NNC(=S)Nc1ccc(cc1)Cl
  • InChi: 1S/C14H14ClN5S2/c15-10-6-8-11(9-7-10)16-13(21)18-20-14(22)19-17-12-4-2-1-3-5-12/h1-9,17H,(H2,16,18,21)(H2,19,20,22)
  • InChiKey: ISCVLKBJGPVDRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-anilino-3-[[(4-chloroanilino)-thioxomethyl]amino]thiourea
  • 1-(4-chlorophenyl)-3-(phenylazanylcarbamothioylamino)thiourea
  • 1-anilino-3-[(4-chlorophenyl)thiocarbamoylamino]thiourea
  • 1-(4-chlorophenyl)-3-[(phenylamino)carbamothioylamino]thiourea
  • 1-(4-chlorophenyl)-3-[[(N'-phenylhydrazino)-thioxomethyl]amino]thiourea
  • 1-(4-chlorophenyl)-3-[(phenylamino)thiocarbamoylamino]thiourea
  • 92253-45-7
  • NSC148168

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0144 0.1702
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0027 0.0027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0352 0.0982
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0027 0.0017
Toxoplasma gondii hypothetical protein 0.0149 0.0799 0.8142
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0036
Brugia malayi hypothetical protein 0.0107 0.0552 0.0552
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0052 0.0078
Loa Loa (eye worm) hypothetical protein 0.1212 0.697 0.6967
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0203 0.0553
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0062
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0025 0.0188
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0231 0.0594
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0053 0.0238 0.0614
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0042 0.0408
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.017 0.0419
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0352 0.4226
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.049
Trichomonas vaginalis esterase, putative 0.0072 0.0352 0.0944
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0077 0.0067
Echinococcus granulosus sterol O acyltransferase 1 0.0149 0.0799 0.0789
Leishmania major GTP-binding protein, putative 0.0021 0.005 0.0505
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0059 0.0624
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0144 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0799 0.2234
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0113
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Schistosoma mansoni hypothetical protein 0.0149 0.0799 0.0789
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Schistosoma mansoni cpg binding protein 0.0097 0.0497 0.0487
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0744 0.0744
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Loa Loa (eye worm) beta-lactamase 0.0072 0.0352 0.0342
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0087 0.0437 1
Onchocerca volvulus 0.0496 0.2814 1
Leishmania major hypothetical protein, conserved 0.0072 0.0352 0.4334
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0087 0.0437 0.0437
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0612 0.3488 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.002 0.0047 0.0036
Schistosoma mansoni sterol O-acyltransferase 1 0.0149 0.0799 0.0789
Brugia malayi steroid hormone receptor 0.0017 0.0027 0.0027
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0077 0.0067
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0124 0.0124
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0144 0.2101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0027 0.0017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.017 0.165
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0025 0.0025
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0027 0.0017
Giardia lamblia DINP protein human, muc B family 0.0019 0.0042 0.0306
Echinococcus granulosus dnaJ subfamily B 0.0866 0.4963 0.4958
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0108 0.056 0.055
Schistosoma mansoni lipoxygenase 0.0177 0.096 0.0951
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0144 0.1544
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0104 0.0538 0.6692
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0342
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0346 0.0928
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.002 0.002
Plasmodium vivax importin-beta 2, putative 0.0028 0.0093 0.0876
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0278
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0551 0.1555
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.011 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0027 0.0017
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.002 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0149 0.0799 0.0789
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.002 0.0047 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0422 0.1146
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0352 0.0352
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0077 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0027 0.0017
Brugia malayi Thioredoxin reductase 0.0047 0.0203 0.0203
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.005 0.004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0027 0.0027
Loa Loa (eye worm) PDE1B protein 0.002 0.0047 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Leishmania major glycerol uptake protein, putative 0.0149 0.0799 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.044
Plasmodium vivax phosphodiesterase gamma, putative 0.002 0.0047 0.0278
Echinococcus granulosus ubiquitin specific protease 41 0.0108 0.056 0.055
Loa Loa (eye worm) hypothetical protein 0.0086 0.0431 0.0421
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Echinococcus granulosus microtubule associated protein 2 0.0672 0.3834 0.3828
Loa Loa (eye worm) hypothetical protein 0.0257 0.1422 0.1413
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0149 0.0799 0.0789
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0047 0.0461
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0203 0.0193
Loa Loa (eye worm) hypothetical protein 0.1212 0.697 0.6967
Loa Loa (eye worm) MBOAT family protein 0.0149 0.0799 0.0789
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0408
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0025 0.0153
Plasmodium falciparum cGMP-specific phosphodiesterase 0.002 0.0047 0.0278
Leishmania major DNA polymerase eta, putative 0.0019 0.0042 0.0408
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.0998 0.0988
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0027 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Loa Loa (eye worm) hhat protein 0.0149 0.0799 0.0789
Mycobacterium ulcerans hypothetical protein 0.0612 0.3488 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0077 0.0689
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0042 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0027 0.0027
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0087 0.0437 0.1226
Loa Loa (eye worm) hypothetical protein 0.0155 0.083 0.0821
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0352 0.0982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.0998 0.0988
Schistosoma mansoni importin beta-1 0.0028 0.0093 0.0083
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0042 0.0438
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0027 0.0017
Brugia malayi Pre-SET motif family protein 0.0064 0.0304 0.0304
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Mycobacterium ulcerans putative regulatory protein 0.0052 0.0231 0.0634
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0042 0.0093
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.002 0.0047 0.0461
Plasmodium vivax glutathione reductase, putative 0.0047 0.0203 0.2297
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.3834 0.3828
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.002 0.0047 0.0461
Brugia malayi MBOAT family protein 0.0149 0.0799 0.0799
Loa Loa (eye worm) histone methyltransferase 0.0031 0.011 0.01
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0108 0.056 0.9415
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.0093
Giardia lamblia hypothetical protein 0.002 0.0047 0.0379
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.011 0.01
Brugia malayi ecdysteroid receptor 0.0017 0.0027 0.0027
Brugia malayi Muscleblind-like protein 0.1212 0.697 0.697
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.002 0.0047 0.0036
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0027 0.0017
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0025 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0071 0.0806
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0047 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0027 0.0027
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.015 0.1797
Echinococcus granulosus muscleblind protein 0.1212 0.697 0.6967
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.002 0.0047 0.0062
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.002 0.0047 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0552 0.0543
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0087 0.0437 0.1226
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0551 0.1555
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0107 0.0552 0.6744
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0149 0.0799 0.0789
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.002 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0593 0.0584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0071 0.0601
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0127 0.0336
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0304 0.3038
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0025 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0438
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0198 0.108 0.1071
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.002 0.0047 0.0036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.2621 0.7507
Trypanosoma brucei trypanothione reductase 0.0047 0.0203 0.2465
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0213 0.0213
Entamoeba histolytica vacuolar protein sorting 26 0.0149 0.0799 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0077 0.0671
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0089 0.0445 0.125
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0071 0.0176
Brugia malayi beta-lactamase 0.0072 0.0352 0.0352
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0047 0.049
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0593 0.7397
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0047 0.0062
Brugia malayi RNA, U transporter 1 0.0079 0.0391 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Schistosoma mansoni kinase 0.0058 0.0268 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Leishmania major trypanothione reductase 0.0047 0.0203 0.2442
Loa Loa (eye worm) hypothetical protein 0.0064 0.0304 0.0294
Trypanosoma cruzi glycerol uptake protein, putative 0.0149 0.0799 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0278
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0534
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0071 0.0777
Echinococcus multilocularis ornithine aminotransferase 0.0087 0.0437 0.0427
Echinococcus multilocularis muscleblind protein 1 0.1212 0.697 0.6967
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0144 0.0134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.015 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0027 0.0017
Toxoplasma gondii GAF domain-containing protein 0.0052 0.0231 0.2278
Leishmania major importin beta-1 subunit, putative 0.0023 0.0062 0.0659
Mycobacterium leprae Probable lipase LipE 0.0072 0.0352 0.0982
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0721 0.0712
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.015 0.014
Toxoplasma gondii exonuclease III APE 0.0037 0.0144 0.1386
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0551 0.1555
Leishmania major glycerol uptake protein, putative 0.0149 0.0799 1
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0173 0.1908
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0047 0.0461
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0948 0.5438 0.5433
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0027 0.0017
Giardia lamblia Kinase, PLK 0.0114 0.0593 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0149 0.0799 0.0789
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0071 0.0176
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0062 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Mycobacterium tuberculosis Conserved protein 0.0072 0.0352 0.0982
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0144 0.1349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0027 0.0017
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0277 0.1538 0.1529
Schistosoma mansoni ap endonuclease 0.0037 0.0144 0.0134
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0144 0.1728
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0279 0.0269
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0438
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0093 0.1075
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0352 0.0944
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.001
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0149 0.0799 1
Mycobacterium tuberculosis Probable aminotransferase 0.0612 0.3488 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.004
Brugia malayi follicle stimulating hormone receptor 0.0948 0.5438 0.5438
Toxoplasma gondii hypothetical protein 0.0085 0.0422 0.4253
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.002 0.001
Schistosoma mansoni ap endonuclease 0.0037 0.0144 0.0134
Echinococcus granulosus zinc finger protein 0.1584 0.9132 0.9131
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.062 0.1754
Brugia malayi Pre-SET motif family protein 0.0436 0.2466 0.2466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0304 0.0294
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0052 0.0078
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.015 0.014
Echinococcus granulosus ornithine aminotransferase 0.0087 0.0437 0.0427
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.017 0.0419
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Echinococcus multilocularis snurportin 1 0.0298 0.166 0.1651
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0149 0.0799 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0593 0.0584
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0071 0.1129
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0177 0.096 0.0951
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0104 0.0538 0.6692
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0551 0.1555
Brugia malayi MBOAT family protein 0.0149 0.0799 0.0799
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0027 0.0017
Entamoeba histolytica hypothetical protein 0.0107 0.0552 0.6744
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.015 0.0361
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.0998 0.0988
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Schistosoma mansoni ran 0.0021 0.005 0.004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0027 0.0017
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Loa Loa (eye worm) hypothetical protein 0.0149 0.0799 0.0789
Brugia malayi hypothetical protein 0.0245 0.1354 0.1354
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0025 0.0043
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0087 0.0437 0.1226
Schistosoma mansoni hypothetical protein 0.0298 0.166 0.1651
Brugia malayi beta-lactamase family protein 0.0072 0.0352 0.0352
Echinococcus multilocularis dnaJ subfamily B 0.0866 0.4963 0.4958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0027 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0352 0.4351
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0067
Schistosoma mansoni coup transcription factor 0.0017 0.0027 0.0017
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0149 0.0799 1
Entamoeba histolytica hypothetical protein 0.0024 0.0071 0.0384
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0027 0.0017
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0087 0.0437 0.1226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0304 0.0294
Brugia malayi hypothetical protein 0.0042 0.0173 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.0998 0.0988
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0352 0.0982
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.0998 0.0988
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0042 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0684 0.0675
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0043
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0278
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0352 0.0944
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.015 0.1423
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0352 0.0342
Giardia lamblia Hypothetical protein 0.002 0.0047 0.0379
Leishmania major cAMP-specific phosphodiesterase, putative 0.002 0.0047 0.0461
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0612 0.3488 1
Mycobacterium ulcerans hypothetical protein 0.0072 0.0352 0.0982
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0027 0.0027
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0025 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0259 0.0675
Trypanosoma cruzi GUP1, putative 0.0149 0.0799 1
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0149 0.0799 0.0789
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0052 0.0231 0.0634
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0177 0.096 0.0951
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0213 0.0213
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0149 0.0799 0.0789
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0173 0.1908
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0089 0.0445 0.125
Plasmodium falciparum cGMP-specific phosphodiesterase 0.002 0.0047 0.0278
Onchocerca volvulus 0.005 0.0221 0.0695
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Schistosoma mansoni DNA polymerase eta 0.0019 0.0042 0.0032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0042 0.0032
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.005 0.0323
Mycobacterium leprae conserved hypothetical protein 0.0052 0.0231 0.0634
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.002 0.0047 0.0036
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0593 0.2031
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0149 0.0799 0.0789
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0352 0.0944
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0108 0.056 0.055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0408
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0218
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0203 0.2297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0304 0.0294
Schistosoma mansoni rab6-interacting 0.0042 0.0173 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.056 0.1545
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.002 0.0047 0.0047
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.002 0.0047 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0551 0.1555
Echinococcus multilocularis cpg binding protein 0.0097 0.0497 0.0487
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0027 0.0017
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0149 0.0799 0.0789
Loa Loa (eye worm) hypothetical protein 0.0049 0.0213 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0047 0.0461
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0104 0.0538 0.0528
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0108 0.056 0.1545
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0071 0.0633
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.002 0.0047 0.0062
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0108 0.056 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Plasmodium falciparum thioredoxin reductase 0.0047 0.0203 0.2297
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0352 0.0982
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.062 0.1754
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0021 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0352 0.0944
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0304 0.0294
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0071 0.0176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0062
Trypanosoma cruzi GUP1, putative 0.0149 0.0799 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0052 0.0078
Onchocerca volvulus 0.0086 0.0431 0.1449
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0149 0.0799 0.8142
Leishmania major hypothetical protein, conserved 0.002 0.0047 0.0461
Echinococcus granulosus dna polymerase kappa 0.0019 0.0042 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0047 0.0461
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0027 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0062
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.049
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0025 0.0218
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Brugia malayi Cytochrome P450 family protein 0.0014 0.001 0.001
Brugia malayi CXXC zinc finger family protein 0.0092 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0342
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0846
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0093 0.0853
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0422 0.1146
Onchocerca volvulus 0.0042 0.0173 0.0521
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0104 0.0538 0.0528
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.0998 0.0998
Schistosoma mansoni cpg binding protein 0.0092 0.0466 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0047 0.0461
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0505
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0173 0.0163
Echinococcus multilocularis ornithine aminotransferase 0.0087 0.0437 0.0427
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0144 0.0386
Brugia malayi nuclear receptor NHR-88 0.0017 0.0027 0.0027
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.002 0.0047 0.0036
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.1734 1 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.015 0.014
Leishmania major hypothetical protein, conserved 0.0037 0.0145 0.1708
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0108 0.056 0.6985
Plasmodium vivax ornithine aminotransferase, putative 0.0087 0.0437 0.532
Echinococcus multilocularis GPCR, family 2 0.0015 0.002 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0027 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0015 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Brugia malayi Cytochrome P450 family protein 0.0022 0.0059 0.0059
Brugia malayi Doublecortin family protein 0.0042 0.0173 0.0173
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0144 0.2902
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0352 0.0982
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0593 0.7397
Schistosoma mansoni hypothetical protein 0.0107 0.0552 0.0543
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0108 0.056 0.055
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.002 0.0047 0.0047
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0093 0.0083
Brugia malayi diacylglycerol acyltransferase 0.0149 0.0799 0.0799
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0025 0.0043
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0027 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0027 0.0027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.015 0.1422
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0277 0.1538 0.1529
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0108 0.056 0.6847
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0087 0.0437 0.1226
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0144 0.0345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0304 0.0294
Mycobacterium ulcerans putative regulatory protein 0.0052 0.0231 0.0634
Schistosoma mansoni survival motor neuron protein 0.005 0.0221 0.0211
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.002 0.0047 0.0062
Entamoeba histolytica hypothetical protein 0.0023 0.0062 0.0261
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.017 0.1874
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0144 0.0144
Schistosoma mansoni ran 0.0021 0.005 0.004
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0149 0.0799 0.0789
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.002 0.0047 0.0461
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0077 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0025 0.0077 0.0846
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0025 0.0188
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0027 0.0017
Echinococcus granulosus snurportin 1 0.0298 0.166 0.1651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0027 0.0017
Brugia malayi hypothetical protein 0.0016 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0438
Plasmodium vivax SET domain protein, putative 0.0064 0.0304 0.3612
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.002 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0127 0.0336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0144 0.1702
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0108 0.056 0.056
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0238 0.2886
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0342
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.0145 0.1708
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0052 0.0078
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0025 0.0188
Schistosoma mansoni loxhd1 0.0042 0.0173 0.0163
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0684 0.0675
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0149 0.0799 0.0789
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0144 0.0345
Brugia malayi Hhat protein 0.0149 0.0799 0.0799
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0149 0.0799 0.0789
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0071 0.0601
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Toxoplasma gondii thioredoxin reductase 0.0047 0.0203 0.1988
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0149 0.0799 0.0789
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0108 0.056 0.055
Echinococcus multilocularis ubiquitin specific protease 41 0.0108 0.056 0.055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0408
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0352 0.0982
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0108 0.056 0.6976
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0203 0.0193
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0027 0.0027
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.002 0.0047 0.0036
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0027 0.0017
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.002 0.0047 0.0036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0203 0.0193
Onchocerca volvulus 0.0064 0.0304 0.0994
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.015 0.1772
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0224 0.0214
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.015 0.1616
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0059 0.0653
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.002 0.0047 0.0379
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.3834 0.3828
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0346 0.0928
Trichomonas vaginalis helicase, putative 0.0021 0.0052 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0752 0.2099
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0352 0.0982
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0015
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0173 0.0163
Echinococcus granulosus o acyltransferase membrane bound domain 0.0149 0.0799 0.0789
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0173 0.0163
Brugia malayi MBOAT family protein 0.0149 0.0799 0.0799
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Mycobacterium tuberculosis Conserved protein 0.0072 0.0352 0.0982
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0593 0.7286
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0551 0.1555
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.002 0.0047 0.0036
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0277 0.1538 0.1538
Plasmodium falciparum phosphodiesterase delta, putative 0.002 0.0047 0.0278
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0104 0.0538 0.6702
Trypanosoma brucei glycerol uptake protein, putative 0.0149 0.0799 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0053 0.0238 0.0614
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0261 0.068
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0108 0.056 0.055
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0593 0.7397
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.002 0.0047 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0259 0.0675
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0027 0.0017
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.005
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0612 0.3488 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0027 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0261 0.068
Schistosoma mansoni rab6-interacting 0.0042 0.0173 0.0163
Trypanosoma brucei glycerol uptake protein, putative 0.0149 0.0799 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0027 0.0017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0304 0.0294
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0149 0.0799 0.0789
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0015
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0173 0.0163
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Treponema pallidum alginate O-acetylation protein (algI) 0.0149 0.0799 1
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0422 0.1146
Loa Loa (eye worm) acetyltransferase 0.014 0.0744 0.0735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0052 0.0078
Schistosoma mansoni lipoxygenase 0.0102 0.0525 0.0515
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Echinococcus multilocularis zinc finger protein 0.1584 0.9132 0.9131
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0431 0.0421
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0213 0.0203
Plasmodium falciparum importin beta, putative 0.0028 0.0093 0.0876
Schistosoma mansoni hypothetical protein 0.0866 0.4963 0.4958
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.001 0.0031
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0077 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0352 0.4334
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0108 0.056 0.6976
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0149 0.0799 0.0789
Plasmodium falciparum phosphodiesterase gamma, putative 0.002 0.0047 0.0278
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0059 0.0049
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.0093
Trichomonas vaginalis ran, putative 0.0021 0.005 0.0072
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0071 0.0601
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0052 0.0078
Echinococcus granulosus RUN 0.0042 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0408
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.015 0.0402
Mycobacterium tuberculosis Probable reductase 0.0107 0.0551 0.1555
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0352 0.0982
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0104 0.0538 0.6692
Brugia malayi cytochrome P450 0.0014 0.001 0.001
Trichomonas vaginalis set domain proteins, putative 0.0496 0.2814 0.8054
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0144 0.1544
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0042 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0027 0.0027
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0077 0.0874
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0141 0.0752 0.2099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.0998 0.0988
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0231 0.266
Loa Loa (eye worm) MBOAT family protein 0.0149 0.0799 0.0789
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.0998 0.0988
Mycobacterium tuberculosis Conserved protein 0.0072 0.0352 0.0982
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0155 0.083 0.083
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0042 0.0032
Plasmodium falciparum ornithine aminotransferase 0.0087 0.0437 0.532
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0087 0.0437 0.1226
Echinococcus multilocularis dna polymerase eta 0.0019 0.0042 0.0032
Toxoplasma gondii ABC1 family protein 0.0072 0.0352 0.3529
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0612 0.3488 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.015 0.0361
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0144 0.1544
Schistosoma mansoni inositol monophosphatase 0.0038 0.015 0.014
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0025 0.0043
Leishmania major hypothetical protein, conserved 0.0149 0.0799 1
Onchocerca volvulus 0.0072 0.0352 0.1165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0552 0.0543
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0062 0.0659
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.002 0.0047 0.0036
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0093 0.1075
Brugia malayi Cytochrome P450 family protein 0.0051 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0027 0.0027
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0087 0.0437 0.0427
Trichomonas vaginalis transmembrane protein nessy, putative 0.0149 0.0799 0.2234
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.062 0.1754
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.1734 1 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.015 0.3035
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0149 0.0799 0.0789
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0015
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0149 0.0799 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.002 0.0047 0.049
Trypanosoma cruzi glycerol uptake protein, putative 0.0149 0.0799 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Loa Loa (eye worm) hypothetical protein 0.0042 0.0173 0.0163
Brugia malayi MBOAT family protein 0.0149 0.0799 0.0799
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0042 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0149 0.0799 0.8142
Brugia malayi beta-lactamase family protein 0.0072 0.0352 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0799 0.2234
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0027 0.0017
Entamoeba histolytica Ran family GTPase 0.0021 0.005 0.01
Echinococcus multilocularis Aminotransferase class III 0.0087 0.0437 0.0427
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0342
Leishmania major hypothetical protein, conserved 0.002 0.0047 0.0461
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.015 0.1772
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0352 0.4334
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0352 0.0342
Leishmania major cytochrome p450-like protein 0.0022 0.0059 0.0624
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0304 0.0294
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0173 0.0163
Echinococcus granulosus cpg binding protein 0.0097 0.0497 0.0487
Echinococcus granulosus importin subunit beta 1 0.0028 0.0093 0.0083
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0593 0.0584
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.015 0.1443
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Loa Loa (eye worm) hypothetical protein 0.0149 0.0799 0.0789
Toxoplasma gondii histone lysine methyltransferase SET1 0.018 0.0978 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0436 0.2466 0.2458
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0346 0.0928
Schistosoma mansoni hypothetical protein 0.0033 0.0124 0.0113
Plasmodium falciparum GAF domain-related protein, putative 0.0052 0.0231 0.266
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0087 0.0437 0.1226
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0104 0.0538 0.6702
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0104 0.0538 0.148
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0059 0.0049
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.002 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0027 0.0017
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0071 0.0633
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Brugia malayi nuclear hormone receptor 0.0017 0.0027 0.0027
Onchocerca volvulus 0.0072 0.0352 0.1165
Mycobacterium ulcerans acetylornithine aminotransferase 0.0087 0.0437 0.1226
Onchocerca volvulus 0.0092 0.0466 0.1575
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.0466 0.0456
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0352 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0047 0.0062
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0149 0.0799 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0027 0.0017
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0141 0.0752 0.2099
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0203 0.2442
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.015 0.22
Brugia malayi MH2 domain containing protein 0.013 0.0684 0.0684
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0145 0.0387
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.002 0.0047 0.0461
Mycobacterium ulcerans beta-lactamase 0.0072 0.0352 0.0982
Mycobacterium ulcerans lipase LipD 0.0072 0.0352 0.0982
Trypanosoma brucei unspecified product 0.0019 0.0042 0.0438
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0744 0.0735
Onchocerca volvulus 0.0042 0.0173 0.0521
Leishmania major glycerol uptake protein, putative 0.0149 0.0799 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0104 0.0538 0.0528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0062 0.0107
Echinococcus granulosus dna polymerase eta 0.0019 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0173 0.0163
Echinococcus granulosus Aminotransferase class III 0.0087 0.0437 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.0671
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0083
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0036
Echinococcus granulosus GPCR family 2 0.0015 0.002 0.001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0027 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0352 0.0944
Entamoeba histolytica hypothetical protein 0.0149 0.0799 1
Leishmania major glycerol uptake protein, putative 0.0149 0.0799 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0027 0.0017
Brugia malayi hypothetical protein 0.0042 0.0173 0.0173
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0149 0.0799 0.0789
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0149 0.0799 0.0789
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.002 0.0047 0.049
Leishmania major glycerol uptake protein, putative 0.0149 0.0799 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0042 0.005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0108 0.056 0.1545
Entamoeba histolytica hypothetical protein 0.0107 0.0552 0.6744
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0278
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0027 0.0017
Echinococcus multilocularis RUN 0.0042 0.0173 0.0163
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0552 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0799 0.2234
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.4631 0.4626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0027 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0846
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Schistosoma mansoni polycystin 1-related 0.0042 0.0173 0.0163
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0155 0.083 0.0821
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0104 0.0538 0.148
Toxoplasma gondii hypothetical protein 0.0052 0.0231 0.2278
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.017 0.165
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0071 0.0176
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0052 0.0078
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.005 0.0411
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0071 0.1129
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0059 0.0141
Loa Loa (eye worm) hypothetical protein 0.0205 0.1122 0.1113
Schistosoma mansoni hypothetical protein 0.0042 0.0173 0.0163
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0352 0.0982
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.0505
Onchocerca volvulus 0.0149 0.0799 0.2767
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0059 0.0049
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0431 0.0421
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0108 0.0108
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1354 0.1345
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0087 0.0437 0.1226
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.015 0.1772
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0144 0.0386
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0149 0.0799 0.0789
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0042 0.0093
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0087 0.0437 1
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0087 0.0437 0.1226
Loa Loa (eye worm) hypothetical protein 0.0149 0.0799 0.0789
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.002 0.0047 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0027 0.0017
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0149 0.0799 0.0789
Trypanosoma brucei polo-like protein kinase 0.0114 0.0593 0.7405
Echinococcus multilocularis sterol O acyltransferase 1 0.0149 0.0799 0.0789
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0593 0.0593
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0025 0.0218
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0027 0.0027
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0108 0.056 0.6976
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0062 0.0107
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0431 0.0421
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Echinococcus multilocularis muscleblind protein 0.1212 0.697 0.6967
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0352 0.0982
Schistosoma mansoni cpg binding protein 0.0097 0.0497 0.0487
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0173 0.0163
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.017 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.002 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Entamoeba histolytica hypothetical protein, conserved 0.0149 0.0799 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0149 0.0799 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0149 0.0799 0.0789
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0352 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0027 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0047 0.0375
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.166 0.1651
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0087 0.0437 0.1226
Leishmania major DNA polymerase kappa, putative 0.0019 0.0042 0.0408
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.0145 0.1708
Onchocerca volvulus 0.0072 0.0352 0.1165
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0144 0.0134
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0352 0.0342
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0059 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Loa Loa (eye worm) glutathione reductase 0.0047 0.0203 0.0193
Loa Loa (eye worm) inositol-1 0.0038 0.015 0.014
Brugia malayi Cytochrome P450 family protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) hhat protein 0.0149 0.0799 0.0789
Brugia malayi glutathione reductase 0.0047 0.0203 0.0203
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0593 0.0584
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0173 0.0163
Schistosoma mansoni hypothetical protein 0.005 0.0221 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Toxoplasma gondii hypothetical protein 0.0052 0.0231 0.2278
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0149 0.0799 0.0789
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0323
Plasmodium falciparum glutathione reductase 0.0047 0.0203 0.2297
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0027 0.0027
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.002 0.0047 0.0461
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.002 0.0047 0.0036
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.002 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0245 0.1354 0.1345
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.005 0.004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0141 0.0752 0.2099
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.0671
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0017
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0032
Schistosoma mansoni zinc finger protein 0.1734 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.002 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Loa Loa (eye worm) MBOAT family protein 0.1734 1 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0149 0.0799 0.0789
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.0998 0.0988
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0104 0.0538 0.148
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.062 0.1754
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0144 0.1702
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0104 0.0538 0.148
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1354 0.1345
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0087 0.0437 0.1226
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0027 0.0017
Trichomonas vaginalis porcupine, putative 0.0149 0.0799 0.2234
Mycobacterium ulcerans L-lysine aminotransferase 0.0087 0.0437 0.1226
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0087 0.0437 0.4403
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0037 0.0145 0.1734
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0438
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.001
Brugia malayi Importin beta-1 subunit 0.0028 0.0093 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0593 0.1641
Brugia malayi Inositol-1 0.0038 0.015 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0027 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0052 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0188
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0027 0.0017
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.002 0.0047 0.0062
Entamoeba histolytica hypothetical protein 0.0107 0.0552 0.6744
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0078
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0342
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0108 0.056 0.055
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0744 0.0735
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0027 0.0017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.5193 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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