Detailed information for compound 552662

Basic information

Technical information
  • TDR Targets ID: 552662
  • Name: (17R)-5-(4-aminobutyl)-1,5-diazabicyclo[15.4. 0]henicosan-6-one
  • MW: 379.623 | Formula: C23H45N3O
  • H donors: 1 H acceptors: 1 LogP: 4.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCCN1CCCN2CCCC[C@H]2CCCCCCCCCCC1=O
  • InChi: 1S/C23H45N3O/c24-17-10-12-19-26-21-13-20-25-18-11-9-15-22(25)14-7-5-3-1-2-4-6-8-16-23(26)27/h22H,1-21,24H2/t22-/m1/s1
  • InChiKey: BMGOFEXYTOOWHE-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (17R)-5-(4-azanylbutyl)-1,5-diazabicyclo[15.4.0]henicosan-6-one
  • oncinotine
  • 21008-79-7
  • Pyrido(1,2-e)(1,5)diazacycloheptadecin-5(6H)-one, 4-(4-aminobutyl)octadecahydro-, (R)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0093 0.1003 0.217
Brugia malayi jmjC domain containing protein 0.0034 0.0085 0.0127
Brugia malayi Bromodomain containing protein 0.0062 0.0515 0.0769
Echinococcus granulosus polycomb protein SCMH1 0.0093 0.1003 0.0966
Schistosoma mansoni ap endonuclease 0.0037 0.0132 0.0106
Echinococcus multilocularis lysine specific demethylase 5A 0.0126 0.1518 0.1483
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0132 0.0236
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0129 0.1556 0.1521
Loa Loa (eye worm) hypothetical protein 0.008 0.0793 0.1184
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0335 0.0578
Toxoplasma gondii exonuclease III APE 0.0037 0.0132 0.1569
Brugia malayi jmjC domain containing protein 0.0244 0.3334 0.4978
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0085 0.0389
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0335 0.5084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0117
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.1556 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0143 0.0102
Loa Loa (eye worm) hypothetical protein 0.0093 0.1003 0.1498
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1475 0.1453
Echinococcus multilocularis SAM and MBT domain containing protein 0.0093 0.1003 0.0966
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0068 0.0619 0.3878
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0111 0.1212
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0041 0.0061
Brugia malayi Muscleblind-like protein 0.0292 0.4071 0.6077
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0085 0.0045
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0187 0.0279
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0085 0.0389
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0132 0.0692
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.1556 1
Onchocerca volvulus Huntingtin homolog 0.0239 0.326 1
Echinococcus granulosus muscleblind protein 0.0292 0.4071 0.4046
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.1576 0.2353
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0041 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0256 0.0382
Loa Loa (eye worm) hypothetical protein 0.0086 0.0897 0.1339
Brugia malayi Bromodomain containing protein 0.0075 0.072 0.1074
Echinococcus multilocularis lamin 0.0053 0.0378 0.0338
Brugia malayi jmjC domain containing protein 0.0034 0.0085 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0085 0.0127
Echinococcus multilocularis transcription factor btf3 0.0068 0.0619 0.0581
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0335 0.202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.0231
Schistosoma mansoni intermediate filament proteins 0.0053 0.0378 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0335 0.202
Loa Loa (eye worm) hypothetical protein 0.0057 0.0444 0.0662
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0444 0.0662
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.2028 0.1995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.0231
Plasmodium vivax JmjC domain containing protein 0.0034 0.0085 0.0116
Brugia malayi MH2 domain containing protein 0.0117 0.137 0.2045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0132 0.0692
Echinococcus multilocularis geminin 0.0331 0.4676 0.4654
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0335 0.202
Loa Loa (eye worm) hypothetical protein 0.0075 0.0722 0.1078
Echinococcus multilocularis muscleblind protein 0.0292 0.4071 0.4046
Loa Loa (eye worm) hypothetical protein 0.0292 0.4071 0.6077
Echinococcus granulosus phd:f box containing protein 0.0034 0.0085 0.0045
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0788 0.075
Loa Loa (eye worm) hypothetical protein 0.0239 0.326 0.4867
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1475 0.1453
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0444 0.6969
Loa Loa (eye worm) hypothetical protein 0.0138 0.1698 0.2535
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0108 0.0068
Echinococcus granulosus tar DNA binding protein 0.0124 0.1475 0.144
Schistosoma mansoni jumonji/arid domain-containing protein 0.013 0.1576 0.1554
Echinococcus multilocularis histone acetyltransferase MYST2 0.0106 0.1202 0.1166
Loa Loa (eye worm) hypothetical protein 0.0052 0.0363 0.0542
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.1003 0.098
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0085 0.0116
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0085 0.006
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0085 0.006
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0244 0.0219
Schistosoma mansoni hypothetical protein 0.0057 0.0444 0.0419
Brugia malayi PHD-finger family protein 0.0049 0.0316 0.0471
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0041 0.0061
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0085 0.0769
Brugia malayi mbt repeat family protein 0.0093 0.1003 0.1498
Schistosoma mansoni transcription factor btf3 0.0068 0.0619 0.0595
Schistosoma mansoni hypothetical protein 0.0331 0.4676 0.4662
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0335 0.05
Loa Loa (eye worm) hypothetical protein 0.0053 0.0378 0.0564
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0111 0.0007
Schistosoma mansoni alpha-glucosidase 0.0137 0.1685 0.1663
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.3984 1
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.1003 0.098
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0041 0.0099
Loa Loa (eye worm) hypothetical protein 0.0113 0.1309 0.1955
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0079 0.0038
Schistosoma mansoni hypothetical protein 0.03 0.4195 0.4181
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.137 0.2045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0108 0.0068
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0085 0.0769
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0079 0.0038
Brugia malayi Bromodomain containing protein 0.0146 0.1827 0.2727
Echinococcus granulosus intermediate filament protein 0.0053 0.0378 0.0338
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0335 0.0295
Echinococcus multilocularis musashi 0.0053 0.0378 0.0338
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0335 0.0578
Onchocerca volvulus 0.0094 0.1019 0.2226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0079 0.0053
Schistosoma mansoni hypothetical protein 0.0094 0.1019 0.0996
Treponema pallidum hypothetical protein 0.0279 0.388 0.9729
Onchocerca volvulus 0.0092 0.0989 0.2121
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0085 0.006
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0444 0.0405
Trypanosoma cruzi transcription factor btf3, putative 0.0068 0.0619 0.3878
Schistosoma mansoni lamin 0.0053 0.0378 0.0353
Echinococcus multilocularis polycomb protein SCMH1 0.0093 0.1003 0.0966
Entamoeba histolytica transcription factor BTF3, putative 0.0068 0.0619 0.1318
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0132 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0108 0.0083
Schistosoma mansoni hypothetical protein 0.0331 0.4676 0.4662
Brugia malayi RNA, U transporter 1 0.008 0.0798 0.1191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0079 0.0053
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0378 0.0564
Loa Loa (eye worm) hypothetical protein 0.0086 0.0897 0.1339
Echinococcus granulosus geminin 0.0331 0.4676 0.4654
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0335 0.202
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0279 0.388 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0444 0.0419
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0085 0.0045
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0093 0.1003 0.217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.0231
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0244 0.0204
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1475 0.1453
Loa Loa (eye worm) ICD-1 protein 0.0068 0.0619 0.0924
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0335 0.0295
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0335 0.202
Brugia malayi hypothetical protein 0.0239 0.326 0.4867
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0085 0.0045
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0106 0.1202 0.1166
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0132 0.0692
Echinococcus granulosus histone acetyltransferase MYST2 0.0106 0.1202 0.1166
Toxoplasma gondii NAC domain-containing protein 0.0068 0.0619 1
Giardia lamblia PHD finger protein 15 0.0057 0.0444 0.081
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0335 0.202
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0129 0.1556 0.1521
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0619 0.1312
Echinococcus granulosus transcription factor Dp 1 0.0075 0.0717 0.0679
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0106 0.1202 0.1795
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.1556 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0111 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0256 0.0216
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0378 0.0564
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0085 0.006
Onchocerca volvulus Alhambra homolog 0.0057 0.0444 0.0229
Schistosoma mansoni jumonji domain containing protein 0.0206 0.2742 0.2723
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0093 0.1003 0.098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0041 0.0015
Plasmodium falciparum phd finger protein, putative 0.0057 0.0444 0.105
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0335 0.0295
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.1019 0.1522
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.2028 0.1995
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0129 0.1556 0.2323
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0111 0.0166
Echinococcus multilocularis lamin dm0 0.0053 0.0378 0.0338
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0085 0.0045
Loa Loa (eye worm) hypothetical protein 0.0106 0.1202 0.1795
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0111 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Echinococcus multilocularis zinc finger protein 0.0038 0.0155 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0111 0.0557
Echinococcus granulosus lamin dm0 0.0053 0.0378 0.0338
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0117 0.1365 0.133
Echinococcus granulosus zinc finger protein 0.0038 0.0155 0.0114
Schistosoma mansoni lamin 0.0053 0.0378 0.0353
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.3984 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0127
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1723 0.4247
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0244 0.3334 0.3307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0256 0.0382
Brugia malayi beta-NAC-like protein 0.0068 0.0619 0.0924
Loa Loa (eye worm) hypothetical protein 0.0292 0.4071 0.6077
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0079 0.0053
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0129 0.1556 0.3734
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0279 0.388 1
Brugia malayi jmjC domain containing protein 0.013 0.1576 0.2353
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0244 0.0204
Echinococcus multilocularis muscleblind protein 1 0.0292 0.4071 0.4046
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0619 0.1312
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0444 0.6969
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0085 0.0045
Loa Loa (eye worm) hypothetical protein 0.0239 0.326 0.4867
Echinococcus granulosus SAM and MBT domain containing protein 0.0093 0.1003 0.0966
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1723 0.4383
Schistosoma mansoni alpha-glucosidase 0.0137 0.1685 0.1663
Echinococcus granulosus lysine specific demethylase 5A 0.013 0.1576 0.1541
Loa Loa (eye worm) hypothetical protein 0.0462 0.6698 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0132 0.0091
Brugia malayi jmjC domain containing protein 0.0034 0.0085 0.0127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0648 0.061
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0132 0.0692
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0085 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0085 0.0127
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0085 0.006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0079 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0256 0.0216
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0097 0.0145
Schistosoma mansoni eyes absent homolog 0.0086 0.0897 0.0873
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0444 0.105
Loa Loa (eye worm) mbt repeat family protein 0.0093 0.1003 0.1498
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0132 0.0236
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0111 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0335 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0335 0.0578
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0132 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Schistosoma mansoni alpha glucosidase 0.0035 0.0111 0.0085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0132 0.0236
Brugia malayi PHD-finger family protein 0.0057 0.0444 0.0662
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1475 0.2202
Echinococcus granulosus peregrin 0.0062 0.0515 0.0476
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1475 0.1453
Schistosoma mansoni hypothetical protein 0.0035 0.0108 0.0083
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.3984 1
Echinococcus multilocularis peregrin 0.0062 0.0515 0.0476
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0244 0.3334 0.3307
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Schistosoma mansoni hypothetical protein 0.0573 0.8427 0.8423
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1475 0.1453
Brugia malayi hypothetical protein 0.0462 0.6698 1
Onchocerca volvulus Huntingtin homolog 0.0239 0.326 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0279 0.388 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0132 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0374 0.5349 0.533
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0111 0.0557
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0106 0.1202 0.1166
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0132 0.0196
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0788 0.075
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0085 0.0127
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0079 0.0038
Echinococcus granulosus snurportin 1 0.03 0.4195 0.4172
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0444 0.0405
Schistosoma mansoni jumonji/arid domain-containing protein 0.013 0.1576 0.1554
Leishmania major hypothetical protein, conserved 0.0034 0.0085 0.0389
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.6698 0.6684
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0374 0.5349 0.533
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0111 0.0557
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0085 0.0389
Trypanosoma brucei protein kinase, putative 0.005 0.0335 0.202
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0117 0.1365 0.133
Brugia malayi TAR-binding protein 0.0124 0.1475 0.2202
Schistosoma mansoni ap endonuclease 0.0037 0.0132 0.0106
Schistosoma mansoni bromodomain containing protein 0.0124 0.1473 0.1451
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0041 0.0099
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0335 0.0527
Brugia malayi hypothetical protein 0.0086 0.0897 0.1339
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0129 0.1556 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0041 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0619 0.1312
Brugia malayi MAP kinase sur-1 0.005 0.0335 0.05
Plasmodium vivax basic transcription factor 3b, putative 0.0068 0.0619 0.1506
Brugia malayi intermediate filament protein 0.0053 0.0378 0.0564
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0132 0.0091
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0111 0.007
Trypanosoma brucei transcription factor BTF3, putative 0.0068 0.0619 0.3878
Entamoeba histolytica hypothetical protein 0.0068 0.0619 0.1318
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.3984 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1475 0.2202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0256 0.0216
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1475 0.144
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.2028 0.3028
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0335 0.202
Brugia malayi mbt repeat family protein 0.0093 0.1003 0.1498
Schistosoma mansoni myelin transcription factor 1 myt1 0.0106 0.1202 0.118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0079 0.0038
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0132 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.137 0.2045
Brugia malayi RNA binding protein 0.0124 0.1475 0.2202
Schistosoma mansoni survival motor neuron protein 0.0094 0.1019 0.0996
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0085 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0648 0.061
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0143 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3984 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0132 0.006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0041 0.0099
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.2028 0.1995
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0129 0.1556 0.1534
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.6698 0.6684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0256 0.0216
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0335 0.0295
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.4195 0.6264
Schistosoma mansoni hypothetical protein 0.004 0.0187 0.0161
Echinococcus granulosus lamin 0.0053 0.0378 0.0338
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.2028 0.3028
Schistosoma mansoni zinc finger protein 0.0038 0.0155 0.0129
Leishmania major basic transcription factor 3a, putative 0.0068 0.0619 0.3878
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.138 0.2061
Loa Loa (eye worm) MBCTL1 0.0106 0.1202 0.1795
Brugia malayi isocitrate dehydrogenase 0.0031 0.0041 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1475 0.2202
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0279 0.388 1
Brugia malayi hypothetical protein 0.0035 0.0108 0.0162
Brugia malayi jmjC domain containing protein 0.0034 0.0085 0.0127
Loa Loa (eye worm) hypothetical protein 0.0083 0.0851 0.127
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0129 0.1556 0.2323
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0378 0.0564
Echinococcus granulosus transcription factor btf3 0.0068 0.0619 0.0581
Trypanosoma brucei glucosidase, putative 0.0035 0.0111 0.0557
Loa Loa (eye worm) RNA binding protein 0.0124 0.1475 0.2202
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0279 0.388 1
Echinococcus multilocularis snurportin 1 0.03 0.4195 0.4172
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.0717 0.0679
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0127
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0335 0.031
Plasmodium falciparum basic transcription factor 3b, putative 0.0068 0.0619 0.1506

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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