Detailed information for compound 554944

Basic information

Technical information
  • TDR Targets ID: 554944
  • Name: 4-hydroxybutyl prop-2-enoate
  • MW: 144.168 | Formula: C7H12O3
  • H donors: 1 H acceptors: 2 LogP: 0.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCCOC(=O)C=C
  • InChi: 1S/C7H12O3/c1-2-7(9)10-6-4-3-5-8/h2,8H,1,3-6H2
  • InChiKey: NDWUBGAGUCISDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-propenoic acid 4-hydroxybutyl ester
  • acrylic acid 4-hydroxybutyl ester
  • 4-hydroxybutyl acrylate
  • prop-2-enoic acid 4-hydroxybutyl ester
  • 172599-74-5
  • 2478-10-6
  • ZINC01841196
  • 275573_ALDRICH
  • 1,4-Butanediol monoacrylate
  • 2-Propenoic acid, 4-hydroxybutyl ester
  • 4-Hydroxybutyl 2-propenoate
  • EINECS 219-606-3

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens jun proto-oncogene Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi bZIP transcription factor family protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus multilocularis jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus granulosus Basic leucine zipper bZIP transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus granulosus jun protein Get druggable targets OG5_131442 All targets in OG5_131442
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0282 0.0387
Onchocerca volvulus 0.0047 0.0376 0.1687
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0046
Onchocerca volvulus Huntingtin homolog 0.0129 0.1239 0.5901
Trichomonas vaginalis sugar transporter, putative 0.0104 0.0972 0.2861
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0247 0.1189
Loa Loa (eye worm) hypothetical protein 0.0099 0.0915 0.1268
Onchocerca volvulus 0.0035 0.0247 0.1057
Trypanosoma brucei delta-6 fatty acid desaturase, putative 0.0017 0.0059 0.0285
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0247 0.0849
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0017 0.0059 0.0074
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0533 0.0689
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0013 0.0016 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2217 1
Trypanosoma cruzi fatty acid desaturase, putative 0.0193 0.19 0.9144
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0055 0.0266
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0075
Leishmania major glucose transporter/membrane transporter D2, putative 0.0104 0.0972 0.4679
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0533 0.0689
Leishmania major myo-inositol/proton symporter (MIT) 0.0047 0.0376 0.1809
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0039 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0247 0.0727
Brugia malayi hypothetical protein 0.0043 0.0337 0.0464
Brugia malayi hypothetical protein 0.0047 0.0376 0.0518
Schistosoma mansoni alpha-glucosidase 0.0148 0.1435 0.1903
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0247 0.1114
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0068
Toxoplasma gondii facilitative glucose transporter GT1 0.0335 0.3398 0.5135
Onchocerca volvulus 0.0047 0.0376 0.1687
Echinococcus multilocularis calcium dependent protein kinase 0.0065 0.0566 0.0748
Trypanosoma brucei THT1 - hexose transporter, putative 0.0104 0.0972 0.4679
Plasmodium vivax hexose transporter 0.0335 0.3398 0.3388
Brugia malayi hypothetical protein 0.008 0.0716 0.0991
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0042 0.0202
Brugia malayi Fatty acid desaturase family protein 0.0017 0.0059 0.0078
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0013 0.0016 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0054 0.0071
Trypanosoma cruzi hexose transporter 0.0104 0.0972 0.4679
Loa Loa (eye worm) hypothetical protein 0.0129 0.1239 0.1718
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0055 0.0069
Toxoplasma gondii glycyl-tRNA synthetase 0.0013 0.0016 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0247 0.1114
Plasmodium falciparum calcium-dependent protein kinase 1 0.007 0.0612 0.0597
Leishmania major hypothetical protein, conserved 0.0047 0.0376 0.1809
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trypanosoma brucei glucose transporter 2A 0.0104 0.0972 0.4679
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.1686 0.234
Trypanosoma cruzi fatty acid desaturase, putative 0.0193 0.19 0.9144
Echinococcus granulosus Sugar transporter ERD6 protein 0.0047 0.0376 0.048
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0055 0.0083
Entamoeba histolytica hypothetical protein 0.0043 0.0337 0.5452
Mycobacterium ulcerans beta-lactamase 0.0035 0.0247 0.0849
Onchocerca volvulus 0.0047 0.0376 0.1687
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0017 0.0059 0.0074
Schistosoma mansoni hypothetical protein 0.0036 0.0259 0.034
Echinococcus granulosus synaptic vesicle 2 protein 0.0047 0.0376 0.048
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0042 0.0202
Schistosoma mansoni protein kinase 0.007 0.0611 0.0808
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0533 0.0704
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0247 0.1114
Echinococcus granulosus solute carrier family 22 0.0047 0.0376 0.048
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0059 0.0285
Echinococcus multilocularis lysyl tRNA synthetase 0.0051 0.0414 0.0545
Loa Loa (eye worm) hypothetical protein 0.0698 0.7194 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0333 0.1504
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0008 0.0037
Plasmodium falciparum mitogen-activated protein kinase 2 0.0367 0.3734 0.3724
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0013 0.0016 0.013
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0533 0.0704
Plasmodium vivax JmjC domain containing protein 0.0017 0.0055 0.004
Trypanosoma brucei Valosin-containing protein 0.0027 0.0161 0.0775
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0282 0.4541
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0031 0.009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0104 0.0972 0.4679
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0118 0.0159
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0056 0.0073
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0013 0.0016 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi Sugar transporter family protein 0.0335 0.3398 0.4721
Brugia malayi jmjC domain containing protein 0.0062 0.0533 0.0737
Chlamydia trachomatis lysine--tRNA ligase 0.0051 0.0414 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0031 0.009
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0134 0.2978
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0282 0.0426
Trypanosoma brucei fatty acid desaturase, putative 0.0209 0.2077 1
Leishmania major delta-5 fatty acid desaturase 0.0017 0.0059 0.0285
Loa Loa (eye worm) hypothetical protein 0.0055 0.0463 0.0639
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0017 0.0059 0.0285
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0104 0.0972 0.2861
Loa Loa (eye worm) Smad1 0.0016 0.0054 0.0071
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0282 0.037
Loa Loa (eye worm) sugar transporter 0.0047 0.0376 0.0518
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0348 0.1024
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0867 0.1148
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0059 0.0285
Giardia lamblia Sugar-proton symporter 0.0047 0.0376 0.62
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0834 0.109
Trichomonas vaginalis glutaminase, putative 0.0289 0.291 0.8563
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0068 0.0086
Plasmodium falciparum calcium-dependent protein kinase 4 0.007 0.0612 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0376 0.1106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4504
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0042 0.0051
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0051 0.0414 0.1217
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0051
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0028 0.0176 0.0519
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0118 0.0152
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Brugia malayi Smad1 0.0016 0.0054 0.0071
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0055 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2742 0.807
Loa Loa (eye worm) hypothetical protein 0.0132 0.1269 0.176
Toxoplasma gondii sugar transporter ST1 0.0047 0.0376 0.0568
Onchocerca volvulus 0.0047 0.0376 0.1687
Trypanosoma cruzi fatty acid desaturase, putative 0.0017 0.0059 0.0285
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0047 0.0376 0.1809
Mycobacterium ulcerans transmembrane alkane 1-monooxygenase AlkB 0.0017 0.0059 0.0204
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0042 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0031 0.009
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0042 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0055 0.0072
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0055 0.0069
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0013 0.0016 0.007
Trichomonas vaginalis glucose transporter, putative 0.0047 0.0376 0.1106
Plasmodium vivax calcium-dependent protein kinase, putative 0.007 0.0612 0.0597
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0047 0.0376 0.1696
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0247 0.1189
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0068 0.0597 0.0825
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0247 0.0727
Trypanosoma brucei sphingolipid delta 4 desaturase, putative 0.0017 0.0059 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2742 0.807
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.007
Echinococcus granulosus microtubule associated protein 2 0.0729 0.7526 1
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni hypothetical protein 0.0179 0.1758 0.2333
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0313 0.3158 0.4388
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0075
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0068 0.0597 0.9755
Loa Loa (eye worm) fatty acid desaturase 0.0017 0.0059 0.0078
Leishmania major protein kinase, putative 0.007 0.0611 0.2944
Leishmania major fatty acid desaturase, putative 0.0017 0.0059 0.0285
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0017 0.0059 0.0074
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4513
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0042 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0055 0.0072
Echinococcus granulosus jun protein 0.0101 0.0945 0.1237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0339
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0176 0.0214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0038
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0793
Entamoeba histolytica hypothetical protein 0.0043 0.0337 0.5452
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0414 0.1422
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.007 0.0611 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.3398 1
Trypanosoma brucei glucosidase, putative 0.0038 0.0282 0.1357
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0055 0.0072
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.007 0.0611 0.0846
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.1686 0.2237
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0134 1
Schistosoma mansoni glucose transport protein 0.0335 0.3398 0.4513
Echinococcus granulosus bloom syndrome protein 0.0023 0.0118 0.0136
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0533 0.0704
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0055 0.0069
Trypanosoma brucei THT1 - hexose transporter, putative 0.0104 0.0972 0.4679
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0017 0.0059 0.0204
Brugia malayi MH1 domain containing protein 0.0016 0.0054 0.0071
Brugia malayi jmjC domain containing protein 0.0017 0.0055 0.0072
Plasmodium vivax lysine--tRNA ligase, putative 0.0051 0.0414 0.0399
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0533 0.0704
Onchocerca volvulus 0.0047 0.0376 0.1687
Plasmodium falciparum calcium-dependent protein kinase 2 0.007 0.0612 0.0597
Onchocerca volvulus 0.0047 0.0376 0.1687
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.186 0.5473
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.007 0.0611 0.2944
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0051 0.0414 0.1991
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0047 0.0376 0.1292
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0042 0.0189
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0042 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0339
Brugia malayi MH2 domain containing protein 0.0016 0.0054 0.0071
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0017 0.0059 0.0285
Entamoeba histolytica hypothetical protein 0.0043 0.0337 0.5452
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi beta-lactamase family protein 0.0035 0.0247 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0104 0.0972 0.2861
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0808
Mycobacterium tuberculosis Probable conserved membrane protein 0.0017 0.0059 0.0267
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0248 0.0325
Mycobacterium ulcerans hypothetical protein 0.0017 0.0059 0.0204
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0042 0.0054
Leishmania major fatty-acid desaturase, putative 0.0209 0.2077 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0031 0.009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4513
Toxoplasma gondii sugar transporter ST2 0.0047 0.0376 0.0568
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.007 0.0612 0.0597
Plasmodium falciparum calcium-dependent protein kinase 3 0.007 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0414 0.1422
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.1686 0.234
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0176 0.0711
Echinococcus multilocularis solute carrier family 22 0.0047 0.0376 0.0495
Onchocerca volvulus 0.0209 0.2077 1
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0055 0.0069
Leishmania major delta-6 fatty acid desaturase 0.0017 0.0059 0.0285
Echinococcus multilocularis solute carrier family 22 0.0047 0.0376 0.0495
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0808
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0134 0.0461
Brugia malayi glycyl-tRNA synthetase 0.0013 0.0016 0.0017
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0013 0.0016 0.0262
Trypanosoma cruzi hexose transporter, putative 0.0047 0.0376 0.1809
Mycobacterium ulcerans electron transfer protein FdxB 0.0017 0.0059 0.0204
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0051 0.0414 0.1991
Brugia malayi Cam kinase protein 1 0.007 0.0611 0.0846
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0247 0.1114
Trypanosoma cruzi fatty acid desaturase, putative 0.0209 0.2077 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0054 0.0068
Loa Loa (eye worm) glutaminase 2 0.0289 0.291 0.4042
Onchocerca volvulus 0.0047 0.0376 0.1687
Onchocerca volvulus 0.01 0.0925 0.4371
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0047 0.0376 0.1292
Loa Loa (eye worm) hypothetical protein 0.0032 0.0215 0.0295
Loa Loa (eye worm) hypothetical protein 0.0094 0.0867 0.1201
Leishmania major fatty acid desaturase, putative 0.0017 0.0059 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Leishmania major glucose transporter, lmgt3 0.0104 0.0972 0.4679
Onchocerca volvulus 0.0047 0.0376 0.1687
Plasmodium vivax sugar transporter, putative 0.0047 0.0376 0.0361
Echinococcus granulosus solute carrier family 22 0.0047 0.0376 0.048
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2742 0.807
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0597 0.0789
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0055 0.0083
Loa Loa (eye worm) hypothetical protein 0.0129 0.1239 0.1718
Onchocerca volvulus 0.0047 0.0376 0.1687
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Onchocerca volvulus 0.0047 0.0376 0.1687
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4513
Brugia malayi beta-lactamase family protein 0.0035 0.0247 0.0339
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0715 0.3443
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni glutaminase 0.0289 0.291 0.3863
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0247 0.0232
Schistosoma mansoni sugar transporter 0.0047 0.0376 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0972 0.2861
Mycobacterium tuberculosis Conserved protein 0.0035 0.0247 0.1114
Echinococcus multilocularis smad 0.0016 0.0054 0.0068
Loa Loa (eye worm) acyl-CoA desaturase 0.0193 0.19 0.2637
Mycobacterium ulcerans glutaminase 0.0289 0.291 1
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0072
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0031 0.0038
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0031 0.0147
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0282 0.0387
Leishmania major hypothetical protein, conserved 0.0017 0.0055 0.0266
Toxoplasma gondii protein kinase, putative 0.0643 0.6617 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0031 0.009
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.2742 0.3809
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0073
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0047 0.0376 0.0495
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0031 0.009
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0013 0.0016 0.0017
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0042 0.0202
Echinococcus granulosus solute carrier family 22 0.0047 0.0376 0.048
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0013 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0068 0.0597 0.0825
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0247 0.0849
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0047 0.0376 0.1696
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.007 0.0612 0.0925
Brugia malayi MH2 domain containing protein 0.0242 0.2416 0.3355
Trichomonas vaginalis glucose transporter, putative 0.0104 0.0972 0.2861
Brugia malayi Sugar transporter family protein 0.0047 0.0376 0.0518
Brugia malayi Major Facilitator Superfamily protein 0.0047 0.0376 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0055 0.0069
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0042 0.0051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0793
Leishmania major hypothetical protein, conserved 0.0035 0.0247 0.1189
Mycobacterium ulcerans ATPase 0.0017 0.0058 0.0199
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0834 0.1104
Schistosoma mansoni hypothetical protein 0.0179 0.1758 0.2333
Loa Loa (eye worm) hypothetical protein 0.0066 0.0574 0.0794
Loa Loa (eye worm) hypothetical protein 0.0051 0.0414 0.0571
Loa Loa (eye worm) fatty acid desaturase 0.0017 0.0059 0.0078
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0059 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0339
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0027 0.0161 0.0146
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.007 0.0612 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0376 0.1106
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Leishmania major delta-4 fatty acid desaturase 0.0017 0.0059 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0434 0.0598
Leishmania major delta-12 fatty acid desaturase 0.0017 0.0059 0.0285
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0247 0.1189
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0055 0.0053
Mycobacterium tuberculosis Conserved protein 0.0035 0.0247 0.1114
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.7526 1
Plasmodium falciparum protein kinase 7 0.0643 0.6617 0.6612
Loa Loa (eye worm) hypothetical protein 0.0246 0.2464 0.3422
Onchocerca volvulus 0.0209 0.2077 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0175 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2742 0.807
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0533 0.0737
Toxoplasma gondii transporter, major facilitator family protein 0.0047 0.0376 0.0568
Echinococcus granulosus calcium dependent protein kinase 0.0065 0.0566 0.0733
Onchocerca volvulus 0.0047 0.0376 0.1687
Echinococcus granulosus General substrate transporter 0.0288 0.2903 0.3845
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni sugar transporter 0.0047 0.0376 0.0495
Onchocerca volvulus 0.008 0.0716 0.335
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0017
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0055 0.0069
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0056 0.0073
Schistosoma mansoni glucose transporter 0.0047 0.0376 0.0495
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.186 0.5473
Trypanosoma cruzi hexose transporter, putative 0.0104 0.0972 0.4679
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0118 0.0347
Echinococcus granulosus Smad4 0.0016 0.0054 0.0051
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0013 0.0016 0.0054
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0013 0.0016 0.0024
Brugia malayi vesicle-fusing ATPase 0.0016 0.0054 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Entamoeba histolytica cdc48-like protein, putative 0.0027 0.0161 0.2539
Leishmania major lysyl-tRNA synthetase, putative 0.0051 0.0414 0.1991
Loa Loa (eye worm) hypothetical protein 0.007 0.0611 0.0846
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0042 0.0202
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.2416 0.3355
Entamoeba histolytica protein kinase, putative 0.007 0.0611 1
Schistosoma mansoni hypothetical protein 0.0043 0.0337 0.0443
Echinococcus granulosus smad 0.0016 0.0054 0.0051
Entamoeba histolytica protein kinase, putative 0.007 0.0611 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0068 0.0597 0.0825
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0533 0.0704
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0047 0.0376 0.0495
Echinococcus granulosus lysyl tRNA synthetase 0.0051 0.0414 0.053
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0282 0.1357
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.008 0.0715 0.1081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0247 0.0339
Schistosoma mansoni protein kinase 0.007 0.0611 0.0808
Brugia malayi isocitrate dehydrogenase 0.0015 0.0042 0.0054
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0068 0.0597 0.1756
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0031 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0434 0.0598
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0013 0.0016 0.0017
Echinococcus granulosus solute carrier family 22 0.0047 0.0376 0.048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0248 0.034
Toxoplasma gondii ABC1 family protein 0.0035 0.0247 0.0373
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0339
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Loa Loa (eye worm) hypothetical protein 0.0053 0.0434 0.0598
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0013 0.0016 0.013
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.007
Brugia malayi hypothetical protein 0.0129 0.1239 0.1718
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0055 0.0053
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.007 0.0611 0.0846
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni glycyl-tRNA synthetase 0.0013 0.0016 0.0016
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.1686 0.2225
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi Major Facilitator Superfamily protein 0.0047 0.0376 0.0518
Giardia lamblia Prolyl-tRNA synthetase 0.0068 0.0597 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4504
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.0017 0.0059 0.0285
Trypanosoma brucei sugar transporter, putative 0.0047 0.0376 0.1809
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0055 0.0069
Entamoeba histolytica hypothetical protein 0.0051 0.0414 0.6722
Plasmodium falciparum lysine--tRNA ligase 0.0051 0.0414 0.0399
Brugia malayi Sugar transporter family protein 0.0047 0.0376 0.0518
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Plasmodium falciparum calcium-dependent protein kinase 5 0.007 0.0612 0.0597
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0247 0.0324
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0027 0.0161 0.2539
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0715 0.3443
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0247 0.1114
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0016 0.0075
Loa Loa (eye worm) major facilitator superfamily transporter 0.0047 0.0376 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0042 0.0054
Brugia malayi major facilitator superfamily protein 0.0047 0.0376 0.0518
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Mycobacterium tuberculosis Conserved protein 0.0035 0.0247 0.1114
Echinococcus multilocularis solute carrier family 22 0.0047 0.0376 0.0495
Brugia malayi MH2 domain containing protein 0.0016 0.0054 0.0071
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0248 0.0309
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0867 0.1148
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0339
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0414 0.0545
Schistosoma mansoni hypothetical protein 0.0335 0.3398 0.4513
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0282 0.083
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0808
Plasmodium vivax CDK-related protein kinase 6, putative 0.0965 1 1
Brugia malayi jmjC domain containing protein 0.0017 0.0055 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0533 0.0704
Echinococcus multilocularis Smad4 0.0016 0.0054 0.0068
Plasmodium falciparum hexose transporter 0.0335 0.3398 0.3388
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0611 0.0808
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.007 0.0612 0.0597
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0333 0.1504
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0247 0.0727
Echinococcus multilocularis solute carrier family 22 0.0047 0.0376 0.0495
Loa Loa (eye worm) glutaminase 0.0289 0.291 0.4042
Onchocerca volvulus 0.0047 0.0376 0.1687
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0042 0.0202
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0017 0.0058 0.0087
Brugia malayi jmjC domain containing protein 0.0017 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0339
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.0945 0.1237
Echinococcus granulosus Fatty acid desaturase type 1 0.0017 0.0059 0.0058
Echinococcus multilocularis General substrate transporter 0.0288 0.2903 0.3855
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0193 0.19 0.1887
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0075
Loa Loa (eye worm) major facilitator superfamily transporter 0.0047 0.0376 0.0518
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0056 0.0073
Brugia malayi MH1 domain containing protein 0.0016 0.0054 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0031 0.009
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.1758 0.8442
Loa Loa (eye worm) RecQ helicase 0.0023 0.0118 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi beta-lactamase 0.0035 0.0247 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0282 0.083
Mycobacterium ulcerans hypothetical protein 0.0017 0.0059 0.0204
Schistosoma mansoni protein kinase 0.007 0.0611 0.0808
Schistosoma mansoni Smad4 0.0016 0.0054 0.0068
Plasmodium vivax proline--tRNA ligase, putative 0.008 0.0715 0.0701
Schistosoma mansoni fatty acid desaturase 0.0017 0.0059 0.0074
Echinococcus multilocularis synaptic vesicle 2 protein 0.0047 0.0376 0.0495
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.2416 0.3355
Trypanosoma cruzi hexose transporter, putative 0.0057 0.0478 0.2299
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0055 0.0266
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.7526 1
Trypanosoma brucei cytochrome b5-dependent oleate desaturase 0.0017 0.0059 0.0285
Echinococcus granulosus GPCR family 2 0.0017 0.0056 0.0054
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0176 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1758 0.5175
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Brugia malayi valosin containing protein 0.0016 0.0054 0.0071
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0008 0.0023
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0282 0.1357
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0118 0.0347
Plasmodium falciparum proline--tRNA ligase 0.008 0.0715 0.0701
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0072
Mycobacterium tuberculosis Putative conserved ATPase 0.0017 0.0058 0.0261
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0248 0.034
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0008 0.0037
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0027 0.0161 0.021
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0031 0.0147
Onchocerca volvulus Putative transporter 0.0047 0.0376 0.1687
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Schistosoma mansoni alpha-glucosidase 0.0148 0.1435 0.1903
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0068 0.0597 1
Brugia malayi small heat shock protein 0.0698 0.7194 1
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0367 0.3734 0.3724
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0054 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0611 0.18
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Brugia malayi jmjC domain containing protein 0.0062 0.0533 0.0737
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0282 0.083
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0867 0.1134
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0055 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0247 0.0727
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0333 0.5587
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0055 0.0266
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0337 0.0443
Loa Loa (eye worm) FAT-3 protein 0.0017 0.0059 0.0078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0337 0.0443
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0533 0.0689
Echinococcus granulosus phd:f box containing protein 0.0017 0.0055 0.0053
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0078
Giardia lamblia Lysyl-tRNA synthetase 0.0051 0.0414 0.6849
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0017 0.0059 0.0285
Onchocerca volvulus Huntingtin homolog 0.0129 0.1239 0.5901
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0247 0.0727
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0597 0.0789
Onchocerca volvulus 0.0035 0.0247 0.1057
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.007 0.0612 0.0925
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0793
Toxoplasma gondii lysine-tRNA ligase 0.0051 0.0414 0.0625
Leishmania major glucose transporter, lmgt2 0.0104 0.0972 0.4679
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0047 0.0376 0.0361
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0247 0.0324
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3_2 0.0017 0.0059 0.0204
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0247 0.0308
Trypanosoma cruzi fatty acid desaturase, putative 0.0017 0.0059 0.0285
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0054 0.0068
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0282 0.4541
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0071
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0017 0.0059 0.0204
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.2742 0.3809
Trichomonas vaginalis esterase, putative 0.0035 0.0247 0.0727
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0715 0.3443
Schistosoma mansoni hypothetical protein 0.0082 0.0745 0.0986
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.0945 0.1251
Mycobacterium ulcerans lipase LipD 0.0035 0.0247 0.0849
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0282 0.083
Giardia lamblia AAA family ATPase 0.0017 0.0058 0.0727
Mycobacterium leprae Probable lipase LipE 0.0035 0.0247 0.414
Mycobacterium ulcerans sugar transporter 0.0047 0.0376 0.1292
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0282 0.083
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0058 0.0087
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0054 0.0071
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Mycobacterium ulcerans hypothetical protein 0.0035 0.0247 0.0849
Brugia malayi Delta5 fatty acid desaturase 0.0017 0.0059 0.0078
Leishmania major glucose transporter, lmgt1 0.0104 0.0972 0.4679
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0715 0.3443
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0068 0.0597 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0376 0.1106
Trypanosoma cruzi hexose transporter, putative 0.0104 0.0972 0.4679
Leishmania major stearic acid desaturase, putative 0.0209 0.2077 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2742 0.807
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0017 0.0059 0.0058
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0027 0.0161 0.0146
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.007 0.0612 0.0597
Schistosoma mansoni jun-related protein 0.0082 0.0745 0.0986
Schistosoma mansoni transient receptor potential channel 0.0062 0.0533 0.0704
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0047 0.0376 1
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni transient receptor potential channel 0.0094 0.0867 0.1148
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0089 0.0074
Trypanosoma cruzi Valosin-containing protein, putative 0.0027 0.0161 0.0775
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0247 0.1114
Loa Loa (eye worm) hypothetical protein 0.0059 0.05 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0376 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0376 0.1106
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0017 0.0059 0.0267
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0054 0.0051
Loa Loa (eye worm) vesicle-fusing ATPase 0.0016 0.0054 0.0071
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0031 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0414 0.0545
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0056 0.007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0072
Trichomonas vaginalis sugar transport protein, putative 0.0047 0.0376 0.1106
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0031 0.0147
Giardia lamblia Hexose transporter 0.0047 0.0376 0.62
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0337 0.0428
Brugia malayi acyl-CoA desaturase 0.0193 0.19 0.2637
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0533 0.0704
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0093
Trypanosoma cruzi sugar transporter, putative 0.0047 0.0376 0.1809
Toxoplasma gondii sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein 0.0017 0.0059 0.009
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0247 0.414
Schistosoma mansoni alpha glucosidase 0.0038 0.0282 0.037
Brugia malayi Fatty acid desaturase family protein 0.0017 0.0059 0.0078
Brugia malayi bZIP transcription factor family protein 0.0101 0.0945 0.1309
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0533 0.0689
Echinococcus multilocularis GPCR, family 2 0.0017 0.0056 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0282 0.1357
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0114 0.1076 0.1426
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0247 0.1114
Schistosoma mansoni sugar transporter 0.0047 0.0376 0.0495
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0259 0.0355
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0056 0.007
Loa Loa (eye worm) hypothetical protein 0.0068 0.0597 0.0825
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Mycobacterium ulcerans integral membrane transport protein 0.0047 0.0376 0.1292
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0434 0.0598
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.1686 0.2237
Trypanosoma brucei glucose transporter 1E 0.0104 0.0972 0.4679
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.0017 0.0059 0.0285
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0051
Echinococcus multilocularis glycyl tRNA synthetase 0.0013 0.0016 0.0016
Trypanosoma cruzi hexose transporter, putative 0.0104 0.0972 0.4679
Brugia malayi jmjC domain containing protein 0.0017 0.0055 0.0072
Brugia malayi major facilitator superfamily protein 0.0047 0.0376 0.0518
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.007
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0042 0.0026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0247 0.0339
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.0808
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0282 0.083
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0041 0.0026
Brugia malayi Major Facilitator Superfamily protein 0.0047 0.0376 0.0518
Entamoeba histolytica hypothetical protein 0.0043 0.0337 0.5452
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0055 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0972 0.2861
Echinococcus multilocularis jun protein 0.0101 0.0945 0.1251
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0008 0.0037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4504
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0335 0.3398 0.4513
Trichomonas vaginalis sugar transporter, putative 0.0047 0.0376 0.1106
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0282 0.0355
Loa Loa (eye worm) hypothetical protein 0.0036 0.0259 0.0355
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0282 0.083
Onchocerca volvulus 0.0017 0.0059 0.014
Plasmodium falciparum stearoyl-CoA desaturase 0.0193 0.19 0.1887
Trypanosoma brucei glucose transporter, putative 0.0104 0.0972 0.4679
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0055 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0282 0.083
Loa Loa (eye worm) sugar transporter 0.0335 0.3398 0.4721
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0715 0.3443
Schistosoma mansoni smad 0.0016 0.0054 0.0068
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0051 0.0414 0.6932
Trichomonas vaginalis glucose transporter, putative 0.0104 0.0972 0.2861
Onchocerca volvulus 0.0047 0.0376 0.1687
Trypanosoma brucei delta-4 fatty acid desaturase 0.0017 0.0059 0.0285
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.007 0.0611 0.0793
Loa Loa (eye worm) beta-lactamase 0.0035 0.0247 0.0339
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0055 0.0053
Onchocerca volvulus 0.0047 0.0376 0.1687
Echinococcus multilocularis geminin 0.0179 0.1758 0.2333
Schistosoma mansoni glucose transport protein 0.0335 0.3398 0.4513
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0176 0.0266
Onchocerca volvulus 0.0035 0.0247 0.1057
Toxoplasma gondii sugar transporter ST3 0.0047 0.0376 0.0568
Schistosoma mansoni transient receptor potential channel 0.0062 0.0533 0.0704
Echinococcus granulosus geminin 0.0179 0.1758 0.2321
Trypanosoma cruzi glucose transporter, putative 0.0047 0.0376 0.1809
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2742 0.807
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0367 0.3734 0.5643
Schistosoma mansoni glucose transport protein 0.0335 0.3398 0.4513
Schistosoma mansoni sugar transporter 0.0047 0.0376 0.0495
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0027 0.0161 0.0775
Brugia malayi hypothetical protein 0.0047 0.0376 0.0518
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0056 0.0054
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0176 0.023
Brugia malayi glutaminase DH11.1 0.0289 0.291 0.4042
Brugia malayi hypothetical protein 0.0047 0.0376 0.0518
Brugia malayi lysyl-tRNA synthetase 0.0051 0.0414 0.0571
Trichomonas vaginalis myo-inositol transporter, putative 0.0047 0.0376 0.1106
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.0017 0.0059 0.0267
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0031 0.0379
Onchocerca volvulus 0.0047 0.0376 0.1687
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0247 0.0324
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0068 0.0597 0.0789
Loa Loa (eye worm) hypothetical protein 0.0047 0.0376 0.0518
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0056 0.0054
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0335 0.3398 0.4504
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0282 0.083
Onchocerca volvulus 0.0047 0.0376 0.1687

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.8571 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.7086 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 38.9 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.1306 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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