Detailed information for compound 555356

Basic information

Technical information
  • TDR Targets ID: 555356
  • Name: [(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-y l)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-y l)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran -3-yl] hydrogen phosphate
  • MW: 548.398 | Formula: C18H25N6O12P
  • H donors: 7 H acceptors: 8 LogP: -6.46 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(nc1=O)N)O)O)n1ccc(nc1=O)N
  • InChi: 1S/C18H25N6O12P/c19-9-1-3-23(17(29)21-9)15-12(27)11(26)8(35-15)6-33-37(31,32)36-14-7(5-25)34-16(13(14)28)24-4-2-10(20)22-18(24)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H2,19,21,29)(H2,20,22,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
  • InChiKey: PTLMIIUMLITBQT-NCOIDOBVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,4R,5R)-5-(4-amino-2-oxo-1-pyrimidinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl [(2R,3S,4R,5R)-5-(4-amino-2-oxo-1-pyrimidinyl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(4-azanyl-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(4-azanyl-2-oxo-pyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(4-amino-2-keto-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(4-amino-2-keto-pyrimidin-1-yl)-4-hydroxy-2-methylol-tetrahydrofuran-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
  • cytidylyl-(3'-5')-cytidine
  • [(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
  • NSC 91550
  • Cytidylyl-(3'.5')-cytidine
  • EINECS 219-802-9
  • NSC 131650

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.003 0.0016 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0045 0.0062
Plasmodium falciparum purine nucleoside phosphorylase 0.0149 0.0714 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0634 0.197
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0142 0.0388
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0142 0.0364
Leishmania major hexokinase, putative 0.0078 0.0298 0.2513
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0077 0.0169
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0036
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.0714 0.4305
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0142 0.0367
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0083 0.0328 0.0854
Echinococcus multilocularis purine nucleoside phosphorylase 0.0655 0.3674 0.3674
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0064 0.0164
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0011 0.0034
Mycobacterium leprae probable uridine phosphorylase 0.0149 0.0714 0.1843
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Toxoplasma gondii hypothetical protein 0.0053 0.0153 0.143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0045 0.008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0022
Echinococcus granulosus hexokinase 0.0078 0.0298 0.0763
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0142 0.0142
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0224 0.1155 0.1155
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0084 0.0186
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0577 0.3219 0.8231
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Echinococcus granulosus uridine phosphorylase 1 0.0149 0.0714 0.1825
Loa Loa (eye worm) hypothetical protein 0.0098 0.0414 0.1285
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.0714 0.4305
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Trypanosoma brucei hypothetical protein, conserved 0.0219 0.1121 0.9706
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0218 0.0218
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0083 0.0328 0.0838
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0045 0.008
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0008 0.0024
Onchocerca volvulus 0.0232 0.1199 0.325
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0142 0.0364
Echinococcus granulosus hexokinase 0.0078 0.0298 0.0763
Schistosoma mansoni transient receptor potential channel 0.0062 0.0204 0.0521
Loa Loa (eye worm) uridine phosphorylase 0.0149 0.0714 0.2217
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0022 0.0056
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0022 0.0141
Mycobacterium tuberculosis Conserved hypothetical protein 0.0149 0.0714 0.1894
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0202 0.1022 0.1022
Brugia malayi CHE-14 protein 0.0042 0.0084 0.0228
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1033 0.2811
Echinococcus granulosus hexokinase 0.0078 0.0298 0.0763
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0241 0.125 0.3197
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0224 0.1155 0.3587
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.039 0.0996
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0142 0.0442
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0142 0.0364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Echinococcus granulosus tar DNA binding protein 0.0136 0.0634 0.1621
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0149 0.0714 0.6144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.003
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0016 0.0111
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0043 0.011
Brugia malayi beta-lactamase family protein 0.0035 0.0045 0.0122
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0142 0.0388
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.0714 0.4305
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0077 0.0169
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0505 0.2801 0.7161
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0634 0.197
Schistosoma mansoni methylthioadenosine phosphorylase 0.0224 0.1155 0.2952
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0142 0.0367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0045 0.0045
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0044 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0012 0.003
Loa Loa (eye worm) hexokinase type II 0.0078 0.0298 0.0927
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0577 0.3219 0.3219
Brugia malayi hypothetical protein 0.0111 0.0489 0.133
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Schistosoma mansoni purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0413 0.1055
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0634 0.1621
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0022 0.0022
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0224 0.1155 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0016 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0043 0.0043
Treponema pallidum pfs protein (pfs) 0.0149 0.0714 0.3191
Treponema pallidum uridine phosphorylase (udp) 0.0149 0.0714 0.3191
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0634 0.0634
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0142 0.0364
Schistosoma mansoni hypothetical protein 0.0064 0.0218 0.0557
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0407 0.2335
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0049 0.0129 0.031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0142 0.0388
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0149 0.0714 0.1926
Onchocerca volvulus 0.0035 0.0045 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Schistosoma mansoni hypothetical protein 0.0064 0.0218 0.0557
Entamoeba histolytica hypothetical protein 0.004 0.0077 0.0213
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0051 0.0138 0.043
Brugia malayi MH2 domain containing protein 0.0138 0.0649 0.1766
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Plasmodium falciparum phosphodiesterase delta, putative 0.003 0.0016 0.0111
Brugia malayi hypothetical protein 0.0239 0.124 0.3375
Toxoplasma gondii phosphorylase family protein 0.0149 0.0714 0.6957
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.07 0.1856
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0126 0.0343
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.07 0.1805
Leishmania major methylthioadenosine phosphorylase, putative 0.0224 0.1155 1
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0142 0.0388
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1199 0.3236
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0142 0.0388
Trichomonas vaginalis esterase, putative 0.0035 0.0045 0.008
Schistosoma mansoni transient receptor potential channel 0.0094 0.039 0.0996
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0388 0.0993
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0413 0.1282
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0064 0.0557
Brugia malayi hypothetical protein 0.0124 0.0565 0.1539
Plasmodium falciparum hexokinase 0.0078 0.0298 0.4118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0044 0.0044
Echinococcus multilocularis peregrin 0.0029 0.0008 0.0008
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0045 0.0062
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.039 0.039
Echinococcus granulosus peregrin 0.0029 0.0008 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0043 0.011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0218 0.0557
Echinococcus multilocularis purine nucleoside phosphorylase 0.0655 0.3674 0.3674
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0153 0.0375
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Plasmodium vivax SET domain protein, putative 0.0029 0.0012 0.0039
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0022 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0043 0.0133
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0142 0.0364
Schistosoma mansoni loxhd1 0.0038 0.0064 0.0164
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0214 0.1778
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Schistosoma mansoni alpha-glucosidase 0.0099 0.0419 0.107
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0064 0.0214 0.0544
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0149 0.0714 0.6144
Schistosoma mansoni hypothetical protein 0.004 0.0075 0.0192
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0045 0.0114
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0241 0.125 0.125
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.003 0.0016 0.0039
Mycobacterium tuberculosis Hypothetical protein 0.0149 0.0714 0.1894
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0022 0.0069
Giardia lamblia hypothetical protein 0.003 0.0016 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0142 0.0364
Echinococcus multilocularis GPCR, family 2 0.0064 0.0218 0.0218
Schistosoma mansoni metabotropic glutamate receptor 0.0039 0.0067 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0634 0.1621
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Schistosoma mansoni hypothetical protein 0.0139 0.0656 0.1676
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0045 0.0062
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0276 0.0705
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0142 0.0364
Leishmania major hypothetical protein, conserved 0.003 0.0016 0.0039
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0045 0.0122
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0073 0.0073
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0008 0.002
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0083 0.0328 0.277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0142 0.0388
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0044 0.0113
Onchocerca volvulus Hexokinase homolog 0.0049 0.0128 0.0328
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Echinococcus multilocularis protein patched 0.0042 0.0084 0.0084
Mycobacterium tuberculosis Conserved protein 0.0035 0.0045 0.0062
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0328 0.277
Leishmania major hexokinase, putative 0.0078 0.0298 0.2513
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0045 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0218 0.0593
Trypanosoma cruzi hexokinase, putative 0.0078 0.0298 0.2513
Onchocerca volvulus 0.0078 0.0298 0.0793
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.039 0.0996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0142 0.0442
Echinococcus granulosus expressed conserved protein 0.0091 0.0373 0.0953
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0083 0.0328 0.0328
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0016 0.0042
Entamoeba histolytica hexokinase 1 0.0078 0.0298 0.1636
Brugia malayi Pre-SET motif family protein 0.0029 0.0012 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0142 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0142 0.0388
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0022 0.0022
Brugia malayi Bromodomain containing protein 0.0029 0.0008 0.0021
Echinococcus granulosus transcription factor btf3 0.004 0.0077 0.0197
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0022 0.0095
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0149 0.0714 0.6144
Echinococcus granulosus methylthioadenosine phosphorylase 0.0224 0.1155 0.2952
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0202 0.1022 0.8844
Schistosoma mansoni hexokinase 0.0078 0.0298 0.0763
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0416 0.1064
Echinococcus multilocularis purine nucleoside phosphorylase 0.0655 0.3674 0.3674
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0142 0.0142
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.009 0.037 0.0946
Loa Loa (eye worm) hypothetical protein 0.0059 0.0185 0.0576
Echinococcus multilocularis lysosomal alpha glucosidase 0.0099 0.0419 0.0419
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0149 0.0714 0.4305
Onchocerca volvulus 0.0038 0.0064 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Onchocerca volvulus Huntingtin homolog 0.0124 0.0565 0.1521
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0084 0.0084
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0077 0.0685
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0202 0.1022 0.8844
Toxoplasma gondii phosphorylase family protein 0.0149 0.0714 0.6957
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.003
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.065 0.065
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0075 0.0281 0.071
Plasmodium vivax phosphodiesterase gamma, putative 0.003 0.0016 0.0077
Schistosoma mansoni hypothetical protein 0.0035 0.0044 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Schistosoma mansoni hypothetical protein 0.004 0.0075 0.0192
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0049 0.0129 0.033
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0655 0.3674 1
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0142 0.0364
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0016 0.0039
Leishmania major basic transcription factor 3a, putative 0.004 0.0077 0.0578
Trypanosoma brucei uridine phosphorylase 0.0149 0.0714 0.6144
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0045 0.0062
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.07 0.1805
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0142 0.0364
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Echinococcus multilocularis geminin 0.0695 0.3911 0.3911
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0328 0.277
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Loa Loa (eye worm) glutamate receptor 0.0031 0.0024 0.0073
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0049 0.0129 0.033
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.1121 0.9706
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0142 0.0364
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0064 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0012 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0142 0.0388
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0049 0.0129 0.0351
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1033 0.3208
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Echinococcus multilocularis hexokinase 0.0078 0.0298 0.0298
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0045 0.0139
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0022 0.0095
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0655 0.3674 1
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0224 0.1155 1
Brugia malayi steroid hormone receptor 0.0052 0.0142 0.0388
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0218 0.0557
Leishmania major nucleoside phosphorylase-like protein 0.0149 0.0714 0.6144
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.0714 0.4305
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0077 0.0578
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0186 0.0577
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1034 0.3213
Schistosoma mansoni uridine phosphorylase 0.0149 0.0714 0.1825
Brugia malayi nuclear hormone receptor 0.0052 0.0142 0.0388
Schistosoma mansoni purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Loa Loa (eye worm) hypothetical protein 0.0097 0.0407 0.1265
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0634 0.1621
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0008 0.002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0022 0.0095
Onchocerca volvulus 0.0049 0.0126 0.0322
Echinococcus multilocularis transcription factor btf3 0.004 0.0077 0.0077
Leishmania major cAMP-specific phosphodiesterase, putative 0.003 0.0016 0.0039
Schistosoma mansoni lipoxygenase 0.0099 0.042 0.1074
Schistosoma mansoni methylthioadenosine phosphorylase 0.0149 0.0714 0.1825
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.16 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0008 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0413 0.1055
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0168 0.0823 0.0823
Schistosoma mansoni coup transcription factor 0.0052 0.0142 0.0364
Schistosoma mansoni hypothetical protein 0.0064 0.0218 0.0557
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0099 0.0419 0.13
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0142 0.0442
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0649 0.2016
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0204 0.0204
Brugia malayi hypothetical protein 0.0029 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Schistosoma mansoni hypothetical protein 0.0029 0.0008 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0142 0.0388
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0407 0.1108
Echinococcus multilocularis hexokinase 0.0078 0.0298 0.0298
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Brugia malayi MTAP 0.0224 0.1155 0.3143
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0142 0.0142
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0016 0.0016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Loa Loa (eye worm) hypothetical protein 0.0124 0.0565 0.1757
Echinococcus multilocularis purine nucleoside phosphorylase 0.0655 0.3674 0.3674
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0034 0.0258
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0022 0.006
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.0714 0.4305
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0371 0.095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0011 0.0049
Schistosoma mansoni patched 1 0.0042 0.0084 0.0214
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0202 0.1022 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0202 0.1022 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0413 0.1123
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0204 0.0521
Trypanosoma brucei hexokinase, putative 0.0078 0.0298 0.2513
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0142 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0142 0.0442
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.003 0.0016 0.0016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Onchocerca volvulus Huntingtin homolog 0.0124 0.0565 0.1521
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0034 0.0258
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1033 0.2811
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0142 0.0364
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0142 0.0388
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0045 0.0114
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.003 0.0016 0.004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0142 0.0388
Brugia malayi nuclear receptor NHR-88 0.0052 0.0142 0.0388
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0084 0.026
Onchocerca volvulus 0.0029 0.0012 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0045 0.008
Loa Loa (eye worm) PDE1B protein 0.0577 0.3219 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0142 0.0142
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0016 0.004
Brugia malayi RNA binding protein 0.0136 0.0634 0.1726
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.003 0.0016 0.0039
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0142 0.0142
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0064 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0016 0.0039
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.065 0.1663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0142 0.0442
Brugia malayi ecdysteroid receptor 0.0052 0.0142 0.0388
Loa Loa (eye worm) hypothetical protein 0.0049 0.0127 0.0395
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0064 0.0164
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.003 0.0016 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0142 0.0142
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0008 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0011 0.0034
Schistosoma mansoni uridine phosphorylase 0.0149 0.0714 0.1825
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0655 0.3674 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0016 0.0111
Echinococcus multilocularis hexokinase type 2 0.0078 0.0298 0.0298
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0149 0.0714 0.6957
Giardia lamblia UPL-1 0.0149 0.0714 0.1926
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0005 0.0014
Brugia malayi metabotropic glutamate receptor type 2 0.0039 0.0067 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0714 0.1908
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0077 0.0169
Plasmodium vivax hexokinase, putative 0.0078 0.0298 0.2865
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.003 0.0016 0.0039
Entamoeba histolytica hypothetical protein 0.0149 0.0714 0.4305
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.16 1
Echinococcus granulosus geminin 0.0695 0.3911 1
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0077 0.0213
Trypanosoma brucei hexokinase 0.0078 0.0298 0.2513
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0149 0.0714 0.3191
Leishmania major hypothetical protein, conserved 0.0035 0.0045 0.0294
Onchocerca volvulus 0.0035 0.0045 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0413 0.1055
Giardia lamblia Hypothetical protein 0.003 0.0016 0.0021
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0083 0.0328 0.277
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0016 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0082
Loa Loa (eye worm) ICD-1 protein 0.004 0.0077 0.024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0199
Echinococcus granulosus metabotropic glutamate receptor 2 0.0067 0.0231 0.059
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Brugia malayi isocitrate dehydrogenase 0.0031 0.0022 0.006
Echinococcus granulosus GPCR family 2 0.0064 0.0218 0.0557
Schistosoma mansoni hypothetical protein 0.0049 0.0126 0.0322
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0098 0.0414 0.0414
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.16 0.4342
Echinococcus multilocularis purine nucleoside phosphorylase 0.0655 0.3674 0.3674
Schistosoma mansoni rab6-interacting 0.0038 0.0064 0.0164
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0084 0.0214
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Schistosoma mansoni metabotropic glutamate receptor 0.0067 0.0231 0.059
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0077 0.0578
Echinococcus granulosus RUN 0.0038 0.0064 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0413 0.0413
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0045 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0714 0.1908
Loa Loa (eye worm) hexokinase 0.0078 0.0298 0.0927
Schistosoma mansoni hypothetical protein 0.0695 0.3911 1
Schistosoma mansoni hypothetical protein 0.0064 0.0218 0.0557
Toxoplasma gondii hexokinase 0.0078 0.0298 0.2865
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0142 0.0142
Onchocerca volvulus 0.0035 0.0045 0.0101
Loa Loa (eye worm) hypothetical protein 0.0139 0.0656 0.2036
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0022 0.0203
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0634 0.1621
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0655 0.3674 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0084 0.0214
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0045 0.0045
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0049 0.0129 0.031
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.16 1
Schistosoma mansoni hypothetical protein 0.004 0.0075 0.0192
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0655 0.3674 1
Echinococcus multilocularis uridine phosphorylase 1 0.0149 0.0714 0.0714
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0045 0.0294
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0634 0.1726
Schistosoma mansoni alpha-glucosidase 0.0099 0.0419 0.107
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0407 0.0407
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0149 0.0714 0.1894
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0407 0.1041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0142 0.0364
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.124 0.124
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0016 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0045 0.008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0045 0.0114
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0204 0.0521
Schistosoma mansoni hypothetical protein 0.004 0.0075 0.0192
Echinococcus multilocularis purine nucleoside phosphorylase 0.0505 0.2801 0.2801
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0011 0.0049
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0022 0.0141
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0045 0.0365
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0142 0.0364
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0067 0.0231 0.0231
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0214 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0045 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0413 0.1055
Onchocerca volvulus 0.0038 0.0064 0.0154
Echinococcus multilocularis expressed conserved protein 0.0091 0.0373 0.0373
Onchocerca volvulus 0.0078 0.0298 0.0793
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Brugia malayi Metabotropic glutamate receptor precursor. 0.008 0.0306 0.0833
Toxoplasma gondii ABC1 family protein 0.0035 0.0045 0.0365
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0016 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0016 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0012 0.003
Onchocerca volvulus 0.0052 0.0142 0.0367
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0043 0.011
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.003 0.0016 0.004
Brugia malayi beta-NAC-like protein 0.004 0.0077 0.021
Plasmodium falciparum phosphodiesterase gamma, putative 0.003 0.0016 0.0111
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Loa Loa (eye worm) beta-lactamase 0.0035 0.0045 0.0139
Mycobacterium tuberculosis Conserved protein 0.0035 0.0045 0.0062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0012 0.0012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0142 0.0388
Schistosoma mansoni survival motor neuron protein 0.0049 0.0126 0.0322
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0224 0.1155 0.3058
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0083 0.0328 0.0838
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.003 0.0016 0.0077
Brugia malayi Hexokinase family protein 0.0078 0.0298 0.0812
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0202 0.1022 0.8844
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0049 0.0129 0.0129
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0049 0.0129 0.031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0142 0.0364
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0241 0.125 0.3884
Brugia malayi hypothetical protein 0.0038 0.0064 0.0175
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.003 0.0016 0.0016
Onchocerca volvulus 0.0049 0.0128 0.0328
Loa Loa (eye worm) hypothetical protein 0.0505 0.2801 0.87
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.003 0.0016 0.0048
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0649 0.2016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0099 0.0419 0.1139
Echinococcus granulosus jumonji domain containing protein 0.004 0.0073 0.0187
Schistosoma mansoni hypothetical protein 0.0695 0.3911 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0048
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0045 0.0062
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0577 0.3219 0.8231
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0035
Brugia malayi PHD-finger family protein 0.0029 0.0008 0.0021
Onchocerca volvulus 0.0066 0.0229 0.0603
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0139
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0064 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0142 0.0388
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Loa Loa (eye worm) hypothetical protein 0.0204 0.1033 0.3208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1146 0.3077
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0149 0.0714 0.1926
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0012 0.0012
Toxoplasma gondii NAC domain-containing protein 0.004 0.0077 0.0685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0142 0.0442
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0016 0.0042
Brugia malayi hypothetical protein 0.0035 0.0044 0.012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0142 0.0367
Echinococcus multilocularis purine nucleoside phosphorylase 0.0655 0.3674 0.3674
Schistosoma mansoni transcription factor btf3 0.004 0.0077 0.0197
Brugia malayi uridine phosphorylase family protein 0.0149 0.0714 0.1943
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0199
Echinococcus granulosus lysosomal alpha glucosidase 0.0099 0.0419 0.107
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0655 0.3674 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0218 0.0676
Brugia malayi Doublecortin family protein 0.0038 0.0064 0.0175
Brugia malayi hypothetical protein 0.0038 0.0064 0.0175
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0016 0.0039
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0045 0.0062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0142 0.0364
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0656 0.1784
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0016 0.0039
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0224 0.1155 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Schistosoma mansoni hypothetical protein 0.0038 0.0064 0.0164
Schistosoma mansoni polycystin 1-related 0.0038 0.0064 0.0164
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Chlamydia trachomatis AMP nucleosidase 0.0149 0.0714 0.5
Brugia malayi beta-lactamase family protein 0.0035 0.0045 0.0122
Echinococcus multilocularis RUN 0.0038 0.0064 0.0064
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0577 0.3219 0.8762
Echinococcus multilocularis purine nucleoside phosphorylase 0.0505 0.2801 0.2801
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.003 0.0016 0.0042
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0142 0.0364
Trypanosoma cruzi hexokinase, putative 0.0078 0.0298 0.2513
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.124 0.317
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0124 0.0565 0.1757
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0022 0.0095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0202 0.1022 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Loa Loa (eye worm) hexokinase 0.0078 0.0298 0.0927
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0218 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0153 0.0475
Loa Loa (eye worm) hypothetical protein 0.0052 0.0142 0.0442
Loa Loa (eye worm) RNA binding protein 0.0136 0.0634 0.197
Brugia malayi jmjC domain containing protein 0.0094 0.0388 0.1057
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0083 0.0328 0.0854
Loa Loa (eye worm) hypothetical protein 0.0094 0.039 0.121
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0016 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0016 0.0039
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0149 0.0714 0.1843
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0218 0.0218
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0064 0.08
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.16 0.433
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0142 0.0364
Echinococcus granulosus leukotriene A 4 hydrolase 0.0241 0.125 0.3197
Toxoplasma gondii Purine nucleoside phosphorylase 0.0149 0.0714 0.6957
Brugia malayi TAR-binding protein 0.0136 0.0634 0.1726
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0077 0.0985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0413 0.1055
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0016 0.0077
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0153 0.0375
Loa Loa (eye worm) glutamate receptor 0.008 0.0306 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0142 0.0388
Schistosoma mansoni transient receptor potential channel 0.0062 0.0204 0.0521
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0072 0.0262 0.0714
Schistosoma mansoni methylthioadenosine phosphorylase 0.0224 0.1155 0.2952
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0204 0.0204
Onchocerca volvulus 0.0078 0.0298 0.0793
Loa Loa (eye worm) hexokinase 0.0049 0.0128 0.0397
Brugia malayi beta-lactamase 0.0035 0.0045 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.1121 0.9706
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0142 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0142 0.0442
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0045 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0045 0.0114
Echinococcus granulosus purine nucleoside phosphorylase 0.0655 0.3674 0.9394
Brugia malayi Hexokinase family protein 0.0049 0.0128 0.0348
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0634 0.1621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0142 0.0442
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0045 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0328 0.0854
Echinococcus granulosus metabotropic glutamate receptor 5 0.0098 0.0414 0.1058
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.003 0.0016 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0077 0.0578
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0218 0.0676
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0202 0.1022 0.8844
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0153 0.0375
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.0714 0.1908
Loa Loa (eye worm) hypothetical protein 0.0239 0.124 0.3852
Entamoeba histolytica hexokinase 2 0.0078 0.0298 0.1636
Brugia malayi jmjC domain containing protein 0.0035 0.0043 0.0117
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0016 0.0039
Schistosoma mansoni rab6-interacting 0.0038 0.0064 0.0164
Brugia malayi hexokinase 0.0078 0.0298 0.0812
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0168 0.0823 0.2104
Brugia malayi Pre-SET motif family protein 0.0204 0.1034 0.2816
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0142 0.0388
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0401
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Mycobacterium tuberculosis Conserved protein 0.0035 0.0045 0.0062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0142 0.0364
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0328 0.277
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0016 0.0111
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0049 0.0129 0.0351
Loa Loa (eye worm) hypothetical protein 0.0042 0.0084 0.026
Trypanosoma brucei hexokinase 0.0078 0.0298 0.2513
Echinococcus multilocularis lysosomal alpha glucosidase 0.0099 0.0419 0.0419
Leishmania major hypothetical protein, conserved 0.0219 0.1121 0.9706
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0083 0.0328 0.0854
Echinococcus multilocularis hexokinase 0.0078 0.0298 0.0298
Echinococcus granulosus hexokinase type 2 0.0078 0.0298 0.0763
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0142 0.0364
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0202 0.1022 0.2614
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0083 0.0328 0.0854
Echinococcus multilocularis protein dispatched 1 0.0047 0.0118 0.0118
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0655 0.3674 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0016 0.0077
Schistosoma mansoni lipoxygenase 0.0168 0.0823 0.2104

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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