Detailed information for compound 563425

Basic information

Technical information
  • TDR Targets ID: 563425
  • Name: (2R,3R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-m ethyl-5-[(E)-prop-1-enyl]-2,3-dihydrobenzofur an
  • MW: 340.413 | Formula: C21H24O4
  • H donors: 0 H acceptors: 0 LogP: 4.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@@H](O2)c1ccc(c(c1)OC)OC
  • InChi: 1S/C21H24O4/c1-6-7-14-10-16-13(2)20(25-21(16)19(11-14)24-5)15-8-9-17(22-3)18(12-15)23-4/h6-13,20H,1-5H3/b7-6+/t13-,20-/m1/s1
  • InChiKey: ITFKWUHXYCXXFF-XSOBDOKWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran
  • (2R,3R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]coumaran
  • acuminatin
  • 41744-39-2
  • Benzofuran, 2-(3,4-dimethoxyphenyl)-2,3-dihydro-7-methoxy-3-methyl-5-(1-propenyl)-, (2R-(2alpha,3beta,5(E)))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni smad1 5 8 and 0.0032 0.0056 0.0202
Brugia malayi Pyruvate kinase, muscle isozyme 0.0149 0.0483 0.0483
Onchocerca volvulus 0.0018 0.0004 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.015 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0018 0.0018
Brugia malayi RNA binding protein 0.0062 0.0165 0.0165
Brugia malayi Cyclin, N-terminal domain containing protein 0.0293 0.1013 0.1013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0644 0.2301 0.2301
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0053 0.0207
Brugia malayi beta-lactamase family protein 0.0074 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0018 0.0018
Brugia malayi Cyclin, N-terminal domain containing protein 0.0422 0.1486 0.1486
Loa Loa (eye worm) hypothetical protein 0.0071 0.0197 0.0197
Echinococcus granulosus pyruvate kinase 0.0076 0.0217 0.0777
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0149 0.0483 0.2849
Loa Loa (eye worm) cyclin domain-containing protein 0.0071 0.0197 0.0197
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.003 0.0047 0.0185
Plasmodium vivax cyclin homologue, putative 0.0071 0.0197 0.0769
Brugia malayi cell division control protein 2 homolog 0.0496 0.1758 0.1758
Schistosoma mansoni pyruvate kinase 0.0149 0.0483 0.1726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0229 0.0894
Echinococcus multilocularis dna polymerase eta 0.0046 0.0106 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0018 0.0018
Echinococcus multilocularis pyruvate kinase 0.0076 0.0217 0.0676
Brugia malayi pyruvate kinase 0.0031 0.0052 0.0052
Onchocerca volvulus 0.0074 0.0209 0.1168
Loa Loa (eye worm) nuclear factor I 0.0018 0.0003 0.0003
Schistosoma mansoni importin beta-1 0.006 0.0159 0.0568
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0032 0.0123
Echinococcus granulosus cyclins 0.0071 0.0197 0.0705
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0779 0.2796 0.2796
Echinococcus multilocularis GPCR, family 2 0.0031 0.0052 0.0161
Onchocerca volvulus 0.0422 0.1486 0.832
Echinococcus granulosus cyclin G2 0.0071 0.0197 0.0705
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Loa Loa (eye worm) hypothetical protein 0.006 0.0159 0.0159
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0229 0.082
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0209 0.0814
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0159 0.062
Trichomonas vaginalis centaurin/arf, putative 0.0017 0.0000000097437 0.000000038014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.001 0.001
Trichomonas vaginalis cyclin B3, putative 0.0071 0.0197 0.0769
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0047 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0031 0.0052 0.0052
Schistosoma mansoni ap endonuclease 0.0039 0.0079 0.0283
Loa Loa (eye worm) hypothetical protein 0.0071 0.0197 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0018 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Leishmania major cathepsin L-like protease 0.0018 0.0004 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.0371 0.1327
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0071 0.0197 0.0705
Schistosoma mansoni DNA polymerase eta 0.0046 0.0106 0.0379
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0443 0.1562 0.1562
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.001 0.0036
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0496 0.1758 0.6285
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0079 0.0079
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Trichomonas vaginalis AGC family protein kinase 0.0715 0.2563 1
Giardia lamblia Cyclin fold protein 1, putative 0.0071 0.0197 0.0732
Echinococcus granulosus cyclin y 0.0071 0.0197 0.0705
Schistosoma mansoni hypothetical protein 0.0071 0.0197 0.0705
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.001 0.0036
Echinococcus granulosus expressed protein 0.0079 0.0229 0.082
Mycobacterium tuberculosis Conserved protein 0.0074 0.0209 0.1196
Trypanosoma cruzi NIMA-related kinase, putative 0.003 0.0047 0.0185
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Giardia lamblia Cyclin B-like protein 0.0071 0.0197 0.0732
Schistosoma mansoni pyruvate kinase 0.0076 0.0217 0.0777
Echinococcus multilocularis cyclin k 0.0071 0.0197 0.0613
Echinococcus granulosus Cyclin L1 0.0071 0.0197 0.0705
Trypanosoma brucei pyruvate kinase 1 0.0149 0.0483 0.1884
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0197 0.0769
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0098 0.0351
Schistosoma mansoni Cyclin fold protein 0.0071 0.0197 0.0705
Onchocerca volvulus 0.0064 0.0173 0.0967
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0197 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0047 0.017
Loa Loa (eye worm) glutaminase 2 0.033 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0483 0.171 0.171
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0032 0.0123
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0018 0.0018
Loa Loa (eye worm) beta-lactamase 0.0074 0.0209 0.0209
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0715 0.2563 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0018 0.0066
Echinococcus multilocularis tumor protein p63 0.0321 0.1115 0.3467
Trypanosoma brucei protein kinase, putative 0.003 0.0047 0.0185
Echinococcus multilocularis axis inhibition protein axin 0.0079 0.0229 0.0713
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0183 0.0656
Toxoplasma gondii pyruvate kinase PyK1 0.0149 0.0483 0.1884
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0017 0.0000000097437 0.000000034843
Brugia malayi pyruvate kinase, muscle isozyme 0.0031 0.0052 0.0052
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0004 0.0016
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0018 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.0079 0.0229 0.082
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Echinococcus granulosus cyclin B 0.0422 0.1486 0.5314
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0071 0.0197 0.0769
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0018 0.0066
Echinococcus multilocularis smad 0.0032 0.0056 0.0175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni ran 0.0026 0.0032 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0209 0.0209
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0715 0.2563 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.009 0.0482
Loa Loa (eye worm) RGS-3 protein 0.0079 0.0229 0.0229
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0635 0.1974
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0205 0.0688 0.2462
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0018 0.0018
Schistosoma mansoni cyclin G 0.0071 0.0197 0.0705
Brugia malayi Cyclin C 0.0071 0.0197 0.0197
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0496 0.1758 0.1758
Onchocerca volvulus Pyruvate kinase homolog 0.0149 0.0483 0.2703
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0053 0.0207
Loa Loa (eye worm) hypothetical protein 0.0064 0.0173 0.0173
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0209 0.0649
Trichomonas vaginalis cyclin B, putative 0.0422 0.1486 0.5797
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.003 0.0047 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0779 0.2796 1
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0117 0.0457
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.009 0.0351
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0209 0.0746
Entamoeba histolytica hypothetical protein 0.003 0.0047 0.0185
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.003 0.0047 0.0185
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0018 0.0018
Loa Loa (eye worm) cyclin domain-containing protein 0.0293 0.1013 0.1013
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0079 0.0229 0.082
Brugia malayi hypothetical protein 0.0071 0.0197 0.0197
Schistosoma mansoni g1/s-specific cyclin C 0.0071 0.0197 0.0705
Loa Loa (eye worm) hypothetical protein 0.0074 0.0209 0.0209
Loa Loa (eye worm) AUR protein kinase 0.0715 0.2563 0.2563
Echinococcus multilocularis pyruvate kinase 0.0149 0.0483 0.1501
Trichomonas vaginalis glutaminase, putative 0.033 0.1149 0.4483
Loa Loa (eye worm) hypothetical protein 0.0079 0.0229 0.0229
Echinococcus granulosus G protein coupled receptor kinase 1 0.07 0.2505 0.8957
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0052 0.0052
Entamoeba histolytica cyclin family protein 0.0293 0.1013 0.3951
Echinococcus multilocularis pyruvate kinase 0.0117 0.0368 0.1144
Schistosoma mansoni serine/threonine protein kinase 0.0715 0.2563 0.9166
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0018 0.0103
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.001 0.0031
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trypanosoma brucei cyclin 3 0.0071 0.0197 0.0769
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.0371 0.1327
Entamoeba histolytica protein kinase, putative 0.0715 0.2563 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni cpg binding protein 0.003 0.0049 0.0177
Trichomonas vaginalis CMGC family protein kinase 0.0496 0.1758 0.6857
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0039
Giardia lamblia Aurora kinase 0.0715 0.2563 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0018 0.0057
Leishmania major folate/biopterin transporter, putative 0.003 0.0047 0.0185
Leishmania major mitotic cyclin, putative 0.0071 0.0197 0.0769
Loa Loa (eye worm) hypothetical protein 0.0422 0.1486 0.1486
Echinococcus multilocularis cyclin 0.0071 0.0197 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0018 0.0018
Echinococcus multilocularis Smad4 0.0032 0.0056 0.0175
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0071 0.0197 0.0769
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Entamoeba histolytica cell division protein kinase 2, putative 0.0496 0.1758 0.6857
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.001 0.0039
Toxoplasma gondii cathepsin CPL 0.0018 0.0004 0.0016
Echinococcus multilocularis Regulator of G protein signaling 20 0.0079 0.0229 0.0713
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0496 0.1758 0.6857
Echinococcus granulosus pyruvate kinase 0.0149 0.0483 0.1726
Echinococcus granulosus tumor protein p63 0.0321 0.1115 0.3987
Loa Loa (eye worm) hypothetical protein 0.0104 0.0318 0.0318
Echinococcus granulosus GPCR family 2 0.0031 0.0052 0.0185
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0018 0.0018
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.003 0.0047 0.0185
Brugia malayi MH1 domain containing protein 0.0032 0.0056 0.0056
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.003 0.0047 0.0185
Leishmania major cathepsin L-like protease 0.0069 0.0191 0.0747
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0067 0.0184 0.0184
Echinococcus multilocularis cpg binding protein 0.0032 0.0056 0.0174
Echinococcus granulosus cyclin y 0.0071 0.0197 0.0705
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0165 0.0592
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0209 0.1196
Entamoeba histolytica cyclin, domain containing protein 0.0071 0.0197 0.0769
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0079 0.0229 0.082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0205 0.0688 0.2462
Entamoeba histolytica cyclin, putative 0.0293 0.1013 0.3951
Onchocerca volvulus 0.0022 0.0018 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0018 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.001 0.0039
Echinococcus multilocularis pyruvate kinase 0.0149 0.0483 0.1501
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Loa Loa (eye worm) cyclin domain-containing protein 0.0071 0.0197 0.0197
Trichomonas vaginalis cyclins, putative 0.0293 0.1013 0.3951
Trichomonas vaginalis AGC family protein kinase 0.0715 0.2563 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Loa Loa (eye worm) pyruvate kinase 0.0149 0.0483 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0277 0.0989
Giardia lamblia PHD finger protein 15 0.0031 0.0053 0.0168
Onchocerca volvulus 0.0018 0.0004 0.0023
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.0003
Echinococcus multilocularis cyclin y 0.0071 0.0197 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Trichomonas vaginalis cyclins, putative 0.0071 0.0197 0.0769
Brugia malayi serine/threonine kinase 12 0.0715 0.2563 0.2563
Onchocerca volvulus 0.0018 0.0004 0.0023
Mycobacterium tuberculosis Conserved protein 0.0074 0.0209 0.1196
Trypanosoma brucei mitotic cyclin 6 0.0422 0.1486 0.5797
Leishmania major cathepsin L-like protease 0.0018 0.0004 0.0016
Brugia malayi hypothetical protein 0.0118 0.0371 0.0371
Plasmodium vivax glutathione reductase, putative 0.0042 0.009 0.0351
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0092 0.0329
Brugia malayi Bromodomain containing protein 0.0031 0.0053 0.0053
Schistosoma mansoni cyclin k 0.0071 0.0197 0.0705
Brugia malayi cyclin fold protein 1 variant b 0.0071 0.0197 0.0197
Echinococcus multilocularis cyclin B 0.0422 0.1486 0.462
Leishmania major cathepsin L-like protease 0.0069 0.0191 0.0747
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0004 0.0004
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0496 0.1758 0.6857
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0209 0.0746
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0084 0.0299
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0032 0.0098
Schistosoma mansoni hypothetical protein 0.0071 0.0197 0.0705
Onchocerca volvulus Pyruvate kinase homolog 0.0149 0.0483 0.2703
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0299 0.0299
Entamoeba histolytica hypothetical protein 0.0118 0.0371 0.1448
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0004 0.0013
Entamoeba histolytica cysteine protease, putative 0.0018 0.0004 0.0016
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0715 0.2563 0.9166
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0185
Echinococcus multilocularis pyruvate kinase 0.0076 0.0217 0.0676
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Echinococcus granulosus cyclins 0.0293 0.1013 0.3622
Echinococcus multilocularis peregrin 0.0031 0.0053 0.0165
Entamoeba histolytica hypothetical protein 0.0049 0.0117 0.0457
Plasmodium falciparum thioredoxin reductase 0.0042 0.009 0.0351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0635 0.1974
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0018 0.0066
Trypanosoma brucei cdc2-related kinase 3 0.0496 0.1758 0.6857
Loa Loa (eye worm) transcription factor SMAD2 0.0475 0.1682 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Brugia malayi hypothetical protein 0.0079 0.0229 0.0229
Trichomonas vaginalis cyclin A, putative 0.0422 0.1486 0.5797
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0293 0.1013 0.3149
Plasmodium vivax pyruvate kinase 2, putative 0.0076 0.0217 0.0848
Entamoeba histolytica hypothetical protein 0.0079 0.0229 0.0894
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.015 0.0584
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0071 0.0197 0.0705
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0169 0.0661
Schistosoma mansoni protein kinase 0.0715 0.2563 0.9166
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0117 0.0457
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0012 0.0042
Plasmodium vivax protein kinase Crk2 0.0496 0.1758 0.6857
Leishmania major trypanothione reductase 0.0042 0.009 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Plasmodium vivax importin-beta 2, putative 0.006 0.0159 0.062
Loa Loa (eye worm) AUR protein kinase 0.0715 0.2563 0.2563
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0056 0.0202
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0079 0.0229 0.082
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Mycobacterium tuberculosis Probable reductase 0.0095 0.0285 0.1659
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.015 0.0584
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Brugia malayi Smad1 0.0032 0.0056 0.0056
Chlamydia trachomatis pyruvate kinase 0.0149 0.0483 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0159 0.062
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0056 0.0175
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0032 0.0032
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0004 0.0015
Entamoeba histolytica cell division protein kinase 2, putative 0.0496 0.1758 0.6857
Loa Loa (eye worm) cyclin domain-containing protein 0.0071 0.0197 0.0197
Echinococcus multilocularis importin subunit beta 1 0.006 0.0159 0.0494
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0071 0.0197 0.0769
Trichomonas vaginalis AGC family protein kinase 0.0715 0.2563 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0079 0.0229 0.0713
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0715 0.2563 1
Trichomonas vaginalis cyclin B, putative 0.0422 0.1486 0.5797
Entamoeba histolytica hypothetical protein 0.0118 0.0371 0.1448
Brugia malayi Pre-SET motif family protein 0.0064 0.0173 0.0173
Trypanosoma brucei cyclin 9 0.0071 0.0197 0.0769
Echinococcus multilocularis cyclin dependent kinase 0.0496 0.1758 0.5464
Loa Loa (eye worm) hypothetical protein 0.0155 0.0506 0.0506
Brugia malayi Protein kinase domain containing protein 0.0496 0.1758 0.1758
Loa Loa (eye worm) hypothetical protein 0.0422 0.1486 0.1486
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0229 0.082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.1669 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Echinococcus granulosus geminin 0.0205 0.0688 0.2462
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0018 0.0066
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0158 0.0617
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0039
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0118 0.0371 0.1448
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0004 0.0023
Giardia lamblia Kinase, CMGC CDK 0.0496 0.1758 0.6844
Trichomonas vaginalis cyclin B3, putative 0.0293 0.1013 0.3951
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0197 0.0769
Trypanosoma brucei aurora B kinase 0.0715 0.2563 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0165 0.0514
Schistosoma mansoni ran 0.0026 0.0032 0.0113
Leishmania major protein kinase, putative 0.003 0.0047 0.0185
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0092 0.0277 0.0277
Brugia malayi PXA domain containing protein 0.0079 0.0229 0.0229
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0033 0.0117
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0053 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0209 0.1743
Brugia malayi jmjC domain containing protein 0.0103 0.0316 0.0316
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0496 0.1758 0.1758
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0018 0.0018
Echinococcus granulosus cyclin dependent kinase 5 0.0496 0.1758 0.6285
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0032 0.0123
Schistosoma mansoni smad1 5 8 and 0.0032 0.0056 0.0202
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0047 0.0185
Brugia malayi TAR-binding protein 0.0062 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Trichomonas vaginalis cyclin D, putative 0.0293 0.1013 0.3951
Giardia lamblia Hypothetical protein 0.0071 0.0197 0.0732
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.003 0.0047 0.0185
Toxoplasma gondii protein kinase domain-containing protein 0.003 0.0047 0.0185
Schistosoma mansoni cyclin G2 0.0071 0.0197 0.0705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0018 0.0057
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0032 0.0123
Echinococcus multilocularis cyclin dependent kinase 5 0.0496 0.1758 0.5464
Echinococcus granulosus importin subunit beta 1 0.006 0.0159 0.0568
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.0371 0.1154
Brugia malayi MH2 domain containing protein 0.0475 0.1682 0.1682
Brugia malayi serine/threonine protein kinase 6 0.0715 0.2563 0.2563
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0053 0.019
Entamoeba histolytica cyclin, putative 0.0422 0.1486 0.5797
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0004 0.0015
Trichomonas vaginalis cyclin D, putative 0.0071 0.0197 0.0769
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.015 0.0584
Leishmania major importin beta-1 subunit, putative 0.0049 0.0117 0.0457
Trichomonas vaginalis CMGC family protein kinase 0.0496 0.1758 0.6857
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0071 0.0197 0.0705
Loa Loa (eye worm) MH2 domain-containing protein 0.0475 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0129 0.0411 0.0411
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0004 0.0013
Mycobacterium ulcerans lipase LipD 0.0074 0.0209 0.1743
Onchocerca volvulus 0.0018 0.0004 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Echinococcus multilocularis cyclin G2 0.0071 0.0197 0.0613
Echinococcus granulosus Smad4 0.0032 0.0056 0.0202
Echinococcus granulosus pyruvate kinase 0.0149 0.0483 0.1726
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0165 0.0592
Brugia malayi hypothetical protein 0.0071 0.0197 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0018 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0018 0.0066
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.0067 0.0184 0.0659
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0018 0.0066
Trichomonas vaginalis cyclin B3, putative 0.0071 0.0197 0.0769
Echinococcus multilocularis regulator of G protein signaling 3 0.0079 0.0229 0.0713
Echinococcus granulosus cyclin G2 0.0071 0.0197 0.0705
Trypanosoma brucei trypanothione reductase 0.0042 0.009 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0229 0.0894
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Plasmodium falciparum cyclin 0.0293 0.1013 0.3951
Schistosoma mansoni pyruvate kinase 0.0149 0.0483 0.1726
Plasmodium falciparum calcium-dependent protein kinase 7 0.003 0.0047 0.0185
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0018 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0056 0.0056
Trichomonas vaginalis cyclins, putative 0.0071 0.0197 0.0769
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Echinococcus granulosus smad 0.0032 0.0056 0.0202
Schistosoma mansoni ap endonuclease 0.0039 0.0079 0.0283
Echinococcus granulosus cyclin dependent kinase 0.0496 0.1758 0.6285
Brugia malayi Pre-SET motif family protein 0.0443 0.1562 0.1562
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0079 0.0308
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0018 0.0057
Echinococcus multilocularis dna polymerase kappa 0.002 0.001 0.0031
Trypanosoma cruzi cdc2-related kinase 3 0.0496 0.1758 0.6857
Leishmania major cathepsin L-like protease 0.0069 0.0191 0.0747
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0004 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0018 0.0066
Onchocerca volvulus 0.0018 0.0004 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0079 0.0308
Trypanosoma brucei rac serine-threonine kinase, putative 0.003 0.0047 0.0185
Echinococcus multilocularis cyclin dependent kinase 1 0.0496 0.1758 0.5464
Echinococcus granulosus tar DNA binding protein 0.0062 0.0165 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0229 0.0894
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.015 0.0584
Giardia lamblia Pyruvate kinase 0.0149 0.0483 0.1851
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0165 0.0592
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0004 0.0023
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Schistosoma mansoni hypothetical protein 0.0644 0.2301 0.8227
Mycobacterium ulcerans glutaminase 0.033 0.1149 1
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0071 0.0197 0.0197
Trypanosoma cruzi pyruvate kinase 2, putative 0.0149 0.0483 0.1884
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0079 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0004 0.0016
Echinococcus granulosus serine/threonine protein kinase 0.003 0.0047 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0635 0.0635
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0000000097437 0.000000038014
Plasmodium vivax SET domain protein, putative 0.0064 0.0173 0.0674
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0209 0.1196
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0018 0.0066
Echinococcus granulosus cyclin k 0.0071 0.0197 0.0705
Plasmodium vivax vivapain-2 0.0018 0.0004 0.0016
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0047 0.0185
Entamoeba histolytica p21-activated kinase 0.003 0.0047 0.0185
Trypanosoma cruzi Protein kinase B 0.003 0.0047 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0496 0.1758 0.6285
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0079 0.0229 0.0894
Schistosoma mansoni hypothetical protein 0.0118 0.0371 0.1327
Schistosoma mansoni cyclin B 0.0422 0.1486 0.5314
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Mycobacterium leprae Probable pyruvate kinase PykA 0.0149 0.0483 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0496 0.1758 0.6857
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0077 0.024
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.011
Echinococcus multilocularis snurportin 1 0.0644 0.2301 0.7153
Entamoeba histolytica hypothetical protein 0.0079 0.0229 0.0894
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.019
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.015 0.0584
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0004 0.0016
Echinococcus granulosus pyruvate kinase 0.0076 0.0217 0.0777
Leishmania major pyruvate kinase 0.0149 0.0483 0.1884
Toxoplasma gondii aurora kinase 0.0715 0.2563 1
Trichomonas vaginalis centaurin gamma, putative 0.0017 0.0000000097437 0.000000038014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0197 0.0197
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0032 0.0084
Entamoeba histolytica hypothetical protein 0.0071 0.0197 0.0769
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0324 0.1893
Entamoeba histolytica ARF GTPase activating protein, putative 0.0017 0.0000000097437 0.000000038014
Giardia lamblia Hypothetical protein 0.0293 0.1013 0.3927
Echinococcus multilocularis expressed protein 0.0079 0.0229 0.0713
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.009 0.0351
Trypanosoma cruzi mitotic cyclin, putative 0.0071 0.0197 0.0769
Echinococcus granulosus cyclin dependent kinase 1 0.0496 0.1758 0.6285
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0285 0.1659
Mycobacterium tuberculosis Conserved protein 0.0074 0.0209 0.1196
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0422 0.1486 0.5797
Echinococcus granulosus axis inhibition protein axin 0.0079 0.0229 0.082
Toxoplasma gondii pyruvate kinase PyKII 0.0076 0.0217 0.0848
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0079 0.0229 0.0229
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Echinococcus granulosus regulator of G protein signaling 3 0.0079 0.0229 0.082
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.003 0.0047 0.0185
Onchocerca volvulus Protein CNPPD1 homolog 0.0071 0.0197 0.1103
Echinococcus granulosus axis inhibition protein axin 0.0079 0.0229 0.082
Plasmodium falciparum cyclin 1 0.0071 0.0197 0.0769
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0047 0.0185
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0047 0.0185
Mycobacterium ulcerans pyruvate kinase 0.0149 0.0483 0.415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0018 0.0066
Loa Loa (eye worm) cyclin C 0.0071 0.0197 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0018 0.0066
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0018 0.0103
Brugia malayi glutathione reductase 0.0042 0.009 0.009
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0004 0.0016
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0017 0.0000000097437 0.0000000097437
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Leishmania major cathepsin L-like protease 0.0018 0.0004 0.0016
Giardia lamblia G2/mitotic-specific cyclin B 0.0422 0.1486 0.578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Echinococcus multilocularis cyclin A3 4 0.0071 0.0197 0.0613
Echinococcus multilocularis regulator of G protein signaling 7 0.0079 0.0229 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0229 0.0894
Trypanosoma cruzi cdc2-related kinase 3 0.0496 0.1758 0.6857
Plasmodium falciparum phd finger protein, putative 0.0031 0.0053 0.0207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0018 0.0066
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0229 0.082
Loa Loa (eye worm) hypothetical protein 0.0074 0.0209 0.0209
Schistosoma mansoni cyclin d 0.0071 0.0197 0.0705
Schistosoma mansoni smad1 5 8 and 0.0032 0.0056 0.0202
Leishmania major hypothetical protein, conserved 0.0058 0.015 0.0584
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0004 0.0015
Brugia malayi Thioredoxin reductase 0.0042 0.009 0.009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.001 0.0036
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0209 0.1196
Mycobacterium ulcerans hypothetical protein 0.0074 0.0209 0.1743
Echinococcus multilocularis geminin 0.0205 0.0688 0.2141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0018 0.0057
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0052 0.0161
Trypanosoma cruzi cyclin 9, putative 0.0071 0.0197 0.0769
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0004 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0018 0.0066
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0715 0.2563 1
Leishmania major cyclin 9, putative 0.0071 0.0197 0.0769
Brugia malayi MH2 domain containing protein 0.0032 0.0056 0.0056
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0079 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0159 0.062
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0165 0.0592
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0004 0.0013
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Brugia malayi Protein kinase domain containing protein 0.003 0.0047 0.0047
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.015 0.0584
Entamoeba histolytica cyclin, domain containing protein 0.0071 0.0197 0.0769
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0293 0.1013 0.3622
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0047 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0197 0.0769
Plasmodium falciparum protein kinase 5 0.0496 0.1758 0.6857
Brugia malayi jmjC domain containing protein 0.004 0.0084 0.0084
Loa Loa (eye worm) AGC/AKT protein kinase 0.003 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0209 0.0814
Echinococcus granulosus cyclin A3 4 0.0071 0.0197 0.0705
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0079 0.0605
Onchocerca volvulus Cyclin L homolog 0.0071 0.0197 0.1103
Leishmania major DNA polymerase eta, putative 0.0046 0.0106 0.0413
Echinococcus multilocularis cysteine protease 0.0018 0.0004 0.0013
Loa Loa (eye worm) cyclin domain-containing protein 0.0071 0.0197 0.0197
Schistosoma mansoni glutaminase 0.033 0.1149 0.4109
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0084 0.0084
Echinococcus granulosus snurportin 1 0.0644 0.2301 0.8227
Brugia malayi MH2 domain containing protein 0.0032 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0018 0.0018
Trichomonas vaginalis cyclin D, putative 0.0293 0.1013 0.3951
Loa Loa (eye worm) hypothetical protein 0.0079 0.0229 0.0229
Schistosoma mansoni axis inhibition protein axin 0.0079 0.0229 0.082
Entamoeba histolytica protein kinase , putative 0.0715 0.2563 1
Trypanosoma cruzi cyclin, putative 0.0422 0.1486 0.5797
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0071 0.0197 0.0769
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0324 0.1893
Leishmania major protein kinase, putative 0.0715 0.2563 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0209 0.0746
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0209 0.0814
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0004 0.0016
Brugia malayi nuclear hormone receptor 0.0022 0.0018 0.0018
Schistosoma mansoni coup transcription factor 0.0022 0.0018 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0209 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.0197 0.0769
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0197 0.0197
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0299 0.0299
Giardia lamblia Cyclin A 0.0293 0.1013 0.3927
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Echinococcus granulosus cyclin B3 1 0.0293 0.1013 0.3622
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0117 0.0457
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0635 0.227
Loa Loa (eye worm) hypothetical protein 0.0074 0.0209 0.0209
Onchocerca volvulus 0.0155 0.0506 0.2833
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Loa Loa (eye worm) hypothetical protein 0.0079 0.0229 0.0229
Trypanosoma cruzi pyruvate kinase 2, putative 0.0149 0.0483 0.1884
Trypanosoma cruzi mitotic cyclin, putative 0.0071 0.0197 0.0769
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Trichomonas vaginalis pyruvate kinase, putative 0.0149 0.0483 0.1884
Onchocerca volvulus 0.0018 0.0004 0.0023
Brugia malayi hypothetical protein 0.0058 0.015 0.015
Echinococcus multilocularis Cyclin L1 0.0071 0.0197 0.0613
Trichomonas vaginalis cyclin B, putative 0.0071 0.0197 0.0769
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0173 0.0674
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0197 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0173 0.0617
Onchocerca volvulus 0.0018 0.0004 0.0023
Brugia malayi Regulator of G protein signaling domain containing protein 0.0079 0.0229 0.0229
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.003 0.0047 0.0185
Trichomonas vaginalis cyclins, putative 0.0422 0.1486 0.5797
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0176 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0635 0.227
Leishmania major GTP-binding protein, putative 0.0026 0.0032 0.0123
Loa Loa (eye worm) hypothetical protein 0.0074 0.0209 0.0209
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0079 0.027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0079 0.0308
Entamoeba histolytica protein kinase, putative 0.003 0.0047 0.0185
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0018 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Plasmodium vivax pyruvate kinase, putative 0.0149 0.0483 0.1884
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0024 0.0027 0.0105
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0165 0.0165
Trypanosoma cruzi cdc2-related kinase 1 0.0496 0.1758 0.6857
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0173 0.0537
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0137 0.0535
Onchocerca volvulus 0.0074 0.0209 0.1168
Trypanosoma cruzi cyclin, putative 0.0422 0.1486 0.5797
Brugia malayi PXA domain containing protein 0.0079 0.0229 0.0229
Brugia malayi PHD-finger family protein 0.0031 0.0053 0.0053
Echinococcus granulosus cyclins 0.0293 0.1013 0.3622
Toxoplasma gondii hypothetical protein 0.0222 0.0753 0.2939
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0032 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0018 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0018 0.0018
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.003 0.0047 0.0185
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0197 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.0779 0.2796 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0018 0.0018
Toxoplasma gondii hypothetical protein 0.0071 0.0197 0.0769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0018 0.0018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0052 0.0161
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Trichomonas vaginalis cyclin B, putative 0.0422 0.1486 0.5797
Trichomonas vaginalis cyclin B, putative 0.0071 0.0197 0.0769
Giardia lamblia Pyruvate kinase 0.0076 0.0217 0.0812
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0084 0.0299
Trichomonas vaginalis set domain proteins, putative 0.0504 0.1786 0.6967
Brugia malayi Cyclin, N-terminal domain containing protein 0.0422 0.1486 0.1486
Brugia malayi serine/threonine-protein kinase 6 0.0715 0.2563 0.2563
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0053 0.019
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0018 0.0066
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0197 0.0197
Leishmania major DNA polymerase eta, putative 0.0032 0.0056 0.0218
Onchocerca volvulus 0.0074 0.0209 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0018 0.0066
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.011 0.0393
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0056 0.0175
Loa Loa (eye worm) pyruvate kinase 0.0149 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0079 0.0229 0.0229
Echinococcus granulosus cyclins 0.0293 0.1013 0.3622
Loa Loa (eye worm) hypothetical protein 0.0098 0.0299 0.0299
Schistosoma mansoni cpg binding protein 0.0032 0.0056 0.02
Loa Loa (eye worm) hypothetical protein 0.0054 0.0135 0.0135
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0191 0.0747
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0079 0.0079
Echinococcus granulosus Regulator of G protein signaling 20 0.0079 0.0229 0.082
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0032 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0209 0.0814
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Loa Loa (eye worm) hypothetical protein 0.0074 0.0209 0.0209
Echinococcus granulosus dna polymerase kappa 0.002 0.001 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0039
Echinococcus granulosus dna polymerase eta 0.0046 0.0106 0.0379
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.003 0.0047 0.0185
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0285 0.1659
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0049 0.0049
Trypanosoma brucei pyruvate kinase 1, putative 0.0149 0.0483 0.1884
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0106 0.0413
Loa Loa (eye worm) AUR protein kinase 0.0715 0.2563 0.2563
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0209 0.1743
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0052
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0056 0.0202
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0052 0.0185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0079 0.0308
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0149 0.0483 0.0483
Loa Loa (eye worm) pyruvate kinase 0.0149 0.0483 0.0483
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0635 0.227
Brugia malayi Cathepsin L-like precursor 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0079 0.0415
Toxoplasma gondii thioredoxin reductase 0.0042 0.009 0.0351
Onchocerca volvulus 0.0071 0.0197 0.1103
Trypanosoma cruzi cyclin 6, putative 0.0422 0.1486 0.5797
Loa Loa (eye worm) glutathione reductase 0.0042 0.009 0.009
Schistosoma mansoni cyclin l 0.0071 0.0197 0.0705
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0032 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0052 0.0052
Trichomonas vaginalis esterase, putative 0.0074 0.0209 0.0814
Echinococcus granulosus pyruvate kinase 0.0076 0.0217 0.0777
Leishmania major mitotic cyclin, putative 0.0071 0.0197 0.0769
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0191 0.0747
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0039
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0026 0.0033 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0173 0.0617
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.003 0.0047 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0191 0.0747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0173 0.0617
Plasmodium falciparum pyruvate kinase 2 0.0076 0.0217 0.0848
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0079 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0079 0.0308
Echinococcus granulosus G1:S specific cyclin D1 0.0071 0.0197 0.0705
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0071 0.0197 0.0613
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0079 0.0308
Loa Loa (eye worm) cysteine protease 0.0018 0.0004 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.0079 0.0229 0.0229
Toxoplasma gondii ABC1 family protein 0.0074 0.0209 0.0814
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0079 0.0246
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0229 0.082
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0079 0.0283
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0018 0.0066
Mycobacterium ulcerans beta-lactamase 0.0074 0.0209 0.1743
Toxoplasma gondii cyclin 4, putative 0.0071 0.0197 0.0769
Plasmodium falciparum glutathione reductase 0.0042 0.009 0.0351
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0209 0.0814
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0056 0.0218
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0098 0.0305
Loa Loa (eye worm) cyclin domain-containing protein 0.0071 0.0197 0.0197
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Plasmodium falciparum serine/threonine protein kinase, putative 0.0715 0.2563 1
Echinococcus multilocularis cyclins 0.0293 0.1013 0.3149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0052 0.0185
Loa Loa (eye worm) hypothetical protein 0.0074 0.0209 0.0209
Schistosoma mansoni smad 0.0032 0.0056 0.0202
Echinococcus multilocularis cyclin dependent kinase 1 0.0496 0.1758 0.5464
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0197 0.0769
Echinococcus multilocularis regulator of G protein signaling 3 0.0079 0.0229 0.0713
Echinococcus multilocularis beta adrenergic receptor kinase 0.0779 0.2796 0.8694
Echinococcus multilocularis G1:S specific cyclin D1 0.0071 0.0197 0.0613
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0056 0.0202
Loa Loa (eye worm) Smad1 0.0032 0.0056 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0018 0.0066
Giardia lamblia Kinase, CMGC CDK 0.0496 0.1758 0.6844
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0165 0.0165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0285 0.1659
Echinococcus granulosus regulator of G protein signaling 7 0.0079 0.0229 0.082
Onchocerca volvulus Cyclin L homolog 0.0071 0.0197 0.1103
Schistosoma mansoni serine/threonine protein kinase 0.0496 0.1758 0.6285
Entamoeba histolytica cyclin C, putative 0.0071 0.0197 0.0769
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0197 0.0769
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.003 0.0047 0.0185
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.003 0.0047 0.0185
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0229 0.082
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Echinococcus multilocularis cyclin t1 0.0071 0.0197 0.0613
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0017 0.0000000097437 0.000000030294
Echinococcus multilocularis pyruvate kinase 0.0076 0.0217 0.0676
Leishmania major hypothetical protein, conserved 0.0074 0.0209 0.0814
Trichomonas vaginalis cyclins, putative 0.02 0.067 0.2615
Plasmodium vivax vivapain-2 0.0018 0.0004 0.0016
Brugia malayi MH1 domain containing protein 0.0032 0.0056 0.0056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0117 0.0457
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0071 0.0197 0.0613
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0033 0.0102
Trypanosoma cruzi aurora B kinase, putative 0.0715 0.2563 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0079 0.0308
Onchocerca volvulus Alhambra homolog 0.0031 0.0053 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0004 0.0016
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Brugia malayi RNA, U transporter 1 0.0172 0.0567 0.0567
Plasmodium falciparum pyruvate kinase 0.0149 0.0483 0.1884
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0209 0.0814
Entamoeba histolytica hypothetical protein 0.003 0.0047 0.0185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0299 0.0299
Onchocerca volvulus Pyruvate kinase homolog 0.0149 0.0483 0.2703
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0092 0.0277 0.0277
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0056 0.0056
Brugia malayi beta-lactamase family protein 0.0074 0.0209 0.0209
Echinococcus granulosus peregrin 0.0031 0.0053 0.019
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0018 0.0018
Trichomonas vaginalis cyclin A, putative 0.0071 0.0197 0.0769
Trypanosoma cruzi cdc2-related kinase 1 0.0496 0.1758 0.6857
Echinococcus granulosus cyclin b3 0.0293 0.1013 0.3622
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0052 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0209 0.0814
Loa Loa (eye worm) glutaminase 0.033 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0018
Loa Loa (eye worm) PXA domain-containing protein 0.0079 0.0229 0.0229
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0056 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Echinococcus granulosus beta-adrenergic receptor kinase 0.0779 0.2796 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0285 0.1659
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0018 0.0066
Schistosoma mansoni cyclin B3 0.0293 0.1013 0.3622
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0229 0.0894
Brugia malayi Importin beta-1 subunit 0.006 0.0159 0.0159
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.003 0.0047 0.0185
Entamoeba histolytica protein kinase, putative 0.0715 0.2563 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747
Echinococcus granulosus cathepsin l1 0.0018 0.0004 0.0015
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0032 0.0123
Brugia malayi nuclear receptor NHR-88 0.0022 0.0018 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.009 0.009
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0285 0.1659
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0209 0.1196
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0079 0.0229 0.082
Echinococcus multilocularis axis inhibition protein axin 0.0079 0.0229 0.0713
Brugia malayi glutaminase DH11.1 0.033 0.1149 0.1149
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0047 0.0185
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0184 0.0184
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0004 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0173 0.0617
Echinococcus granulosus cyclins 0.0293 0.1013 0.3622
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0018 0.0018
Trichomonas vaginalis cyclins, putative 0.0422 0.1486 0.5797
Giardia lamblia Hypothetical protein 0.0071 0.0197 0.0732
Brugia malayi Pyruvate kinase, M2 isozyme 0.0149 0.0483 0.0483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0095 0.0285 0.28
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.001 0.0039
Brugia malayi regulator of G-protein signaling rgs-7 0.0079 0.0229 0.0229
Plasmodium falciparum importin beta, putative 0.006 0.0159 0.062
Entamoeba histolytica hypothetical protein 0.0118 0.0371 0.1448
Toxoplasma gondii cyclin dependent kinase binding protein 0.0071 0.0197 0.0769
Echinococcus granulosus cyclin t1 0.0071 0.0197 0.0705
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0017 0.0000000097437 0.000000038014
Loa Loa (eye worm) hypothetical protein 0.0079 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Trichomonas vaginalis cyclin B, putative 0.0422 0.1486 0.5797
Entamoeba histolytica Ran family GTPase 0.0026 0.0032 0.0123
Schistosoma mansoni axis inhibition protein axin 0.0079 0.0229 0.082
Trichomonas vaginalis pyruvate kinase, putative 0.0149 0.0483 0.1884
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0079 0.0229 0.0713
Echinococcus multilocularis cysteine protease 0.0018 0.0004 0.0013
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0071 0.0197 0.0769
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Echinococcus multilocularis aurora kinase A 0.0715 0.2563 0.7969
Onchocerca volvulus 0.0047 0.011 0.0615
Brugia malayi ecdysteroid receptor 0.0022 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0635 0.227
Leishmania major cathepsin L-like protease 0.0018 0.0004 0.0016
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0316 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0018 0.0018
Leishmania major cathepsin L-like protease 0.0018 0.0004 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0018 0.0057
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0209 0.1196
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0173 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0715 0.2563 0.7969
Loa Loa (eye worm) RNA binding protein 0.0062 0.0165 0.0165
Trichomonas vaginalis cyclin B, putative 0.0293 0.1013 0.3951
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0185
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0018 0.0018
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.003 0.0047 0.0185
Brugia malayi hypothetical protein 0.0037 0.0075 0.0075
Trypanosoma cruzi NIMA-related kinase, putative 0.003 0.0047 0.0185
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0053 0.0207
Echinococcus granulosus aurora kinase A 0.0715 0.2563 0.9166
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0079 0.0308
Echinococcus multilocularis cyclin b3 0.0293 0.1013 0.3149
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0079 0.0229 0.082
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0047 0.0185
Echinococcus multilocularis cyclin B3 1 0.0293 0.1013 0.3149
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.001 0.0039
Brugia malayi beta-lactamase 0.0074 0.0209 0.0209
Echinococcus granulosus cyclins 0.0293 0.1013 0.3622
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0039
Schistosoma mansoni z-protein (S1r protein) 0.0079 0.0229 0.082
Echinococcus multilocularis cyclin G2 0.0071 0.0197 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0173 0.0617
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0185
Trypanosoma brucei unspecified product 0.002 0.001 0.0039
Trypanosoma cruzi serine/threonine protein kinase, putative 0.003 0.0047 0.0185
Leishmania major serine/threonine-protein kinase a, putative 0.003 0.0047 0.0185
Trypanosoma brucei mitotic cyclin 0.0071 0.0197 0.0769
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0004 0.0016
Brugia malayi hypothetical protein 0.0155 0.0506 0.0506
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0045 0.0103 0.0103
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0238 0.0851
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0053 0.0165
Echinococcus multilocularis regulator of G protein signaling 0.0079 0.0229 0.0713
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0079 0.0308
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0209 0.1196
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0893 0.3216 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0165 0.0165
Loa Loa (eye worm) cyclin domain-containing protein 0.2742 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0004 0.0015
Echinococcus granulosus cpg binding protein 0.0032 0.0056 0.02
Loa Loa (eye worm) pyruvate kinase-PB 0.0104 0.0318 0.0318
Loa Loa (eye worm) ctsf protein 0.0018 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0032 0.0056 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0004 0.0016
Brugia malayi steroid hormone receptor 0.0022 0.0018 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0162 0.0578
Plasmodium vivax cyclin 4, putative 0.0071 0.0197 0.0769
Leishmania major cyclin 0.0422 0.1486 0.5797
Trichomonas vaginalis AGC family protein kinase 0.0715 0.2563 1
Entamoeba histolytica protein kinase domain containing protein 0.0715 0.2563 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0191 0.0747
Entamoeba histolytica cyclin family protein 0.0293 0.1013 0.3951
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.003 0.0047 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0293 0.1013 0.3951
Echinococcus multilocularis rac serine:threonine kinase 0.003 0.0047 0.0147
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0324 0.4216
Echinococcus granulosus cyclin 0.0071 0.0197 0.0705
Onchocerca volvulus 0.003 0.0049 0.0277
Echinococcus multilocularis cyclin y 0.0071 0.0197 0.0613
Brugia malayi hypothetical protein 0.0079 0.0229 0.0229
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0084 0.0299
Brugia malayi Regulator of G protein signaling domain containing protein 0.0079 0.0229 0.0229
Leishmania major protein kinase, putative 0.003 0.0047 0.0185
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0316 0.0981
Entamoeba histolytica pyruvate kinase, putative 0.0104 0.0318 0.124
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0000000097437 0.000000038014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0635 0.227
Trypanosoma cruzi CYC2-like cyclin, putative 0.0422 0.1486 0.5797
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0004 0.0023
Schistosoma mansoni Smad4 0.0032 0.0056 0.0202
Trypanosoma brucei cdc2-related kinase 1 0.0496 0.1758 0.6857
Trichomonas vaginalis cyclins, putative 0.0422 0.1486 0.5797
Onchocerca volvulus 0.0504 0.1786 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0049 0.0049
Trichomonas vaginalis AGC family protein kinase 0.003 0.0047 0.0185
Trichomonas vaginalis cyclins, putative 0.0422 0.1486 0.5797
Trichomonas vaginalis CMGC family protein kinase 0.0496 0.1758 0.6857
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0049 0.0177
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0018 0.0066
Leishmania major pyruvate kinase 0.0149 0.0483 0.1884
Entamoeba histolytica hypothetical protein 0.0079 0.0229 0.0894
Echinococcus multilocularis G protein coupled receptor kinase 1 0.07 0.2505 0.7788
Leishmania major DNA polymerase kappa, putative 0.002 0.001 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0165 0.0592
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0496 0.1758 0.1758
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0229 0.0894
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0209 0.1196
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0017 0.0000000097437 0.000000038014
Brugia malayi A-kinase anchor protein 10, precursor 0.0079 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0079 0.0229 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0209 0.0814
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0324 0.1893
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0106 0.0413
Trichomonas vaginalis ran, putative 0.0026 0.0032 0.0123
Loa Loa (eye worm) hypothetical protein 0.0046 0.0106 0.0106
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0092 0.0286
Loa Loa (eye worm) CYL-1 protein 0.0071 0.0197 0.0197
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0018 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0018 0.0018
Schistosoma mansoni cyclins 0.0293 0.1013 0.3622
Loa Loa (eye worm) fibroinase 0.0018 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0191 0.0747

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 28.7 uM Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA ChEMBL. 19880317
IC50 (binding) = 223 uM Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA ChEMBL. 19880317
MIC (functional) > 100 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 10799 by broth microdilution method ChEMBL. 19658431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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