Detailed information for compound 566146

Basic information

Technical information
  • TDR Targets ID: 566146
  • Name: tazettine
  • MW: 331.363 | Formula: C18H21NO5
  • H donors: 1 H acceptors: 1 LogP: 1.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@H]1C=C[C@@]23[C@H](C1)N(C)C[C@@]3(O)OCc1c2cc2OCOc2c1
  • InChi: 1S/C18H21NO5/c1-19-9-18(20)17(4-3-12(21-2)6-16(17)19)13-7-15-14(22-10-23-15)5-11(13)8-24-18/h3-5,7,12,16,20H,6,8-10H2,1-2H3/t12-,16+,17+,18-/m1/s1
  • InChiKey: YLWAQARRNQVEHD-PBZHRCKQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CHEBI:32185

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei lipase domain protein, putative 0.0120321 0.342566 0.310286
Echinococcus granulosus protein kinase c eta type 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis tubulin alpha 1C chain 0.0233635 0.735387 0.730378
Trichomonas vaginalis tubulin epsilon chain, putative 0.0309965 1 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.00312409 0.0337547 0.0235362
Echinococcus multilocularis tubulin delta chain 0.00799564 0.202635 0.187543
Echinococcus granulosus tubulin gamma 1 chain 0.019624 0.605754 0.598292
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis neuropeptide Y receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis neuropeptide Y receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0029348 0.0271928 0.0087793
Loa Loa (eye worm) hypothetical protein 0.00969222 0.26145 0.247471
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.00390803 0.0609313 0.0431563
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis Diacylglycerol kinase theta 0.00276313 0.0212415 0.00271529
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00818063 0.209048 0.194077
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Brugia malayi GnHR receptor homolog 0.00818063 0.209048 0.194077
Echinococcus granulosus g-protein coupled receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Trypanosoma brucei rac serine-threonine kinase, putative 0.00390803 0.0609313 0.0148229
Loa Loa (eye worm) carboxylesterase 0.0213353 0.665078 0.658739
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Brugia malayi Protein kinase c protein 2 0.0127113 0.366113 0.354114
Schistosoma mansoni neuropeptide receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0120321 0.342566 0.330122
Trichomonas vaginalis tubulin beta chain, putative 0.0309965 1 1
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Leishmania major hypothetical protein, conserved 0.0120321 0.342566 0.319599
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00818063 0.209048 0.194077
Echinococcus multilocularis serine threonine protein kinase 0.0137719 0.40288 0.391578
Schistosoma mansoni tubulin subunit delta 0.00799564 0.202635 0.187543
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Brugia malayi Melatonin receptor type 1A 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin alpha-2 chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00818063 0.209048 0.194077
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00818063 0.209048 0.194077
Trichomonas vaginalis tubulin beta chain, putative 0.0233635 0.735387 0.719092
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Mycobacterium ulcerans cell division protein FtsZ 0.00799564 0.202635 0.249361
Brugia malayi follicle stimulating hormone receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin alpha 3 chain 0.0233635 0.735387 0.730378
Echinococcus multilocularis Endonuclease G 0.00519634 0.105593 0.0886633
Schistosoma mansoni serine/threonine protein kinase 0.016535 0.498669 0.489179
Echinococcus granulosus carboxylesterase 5A 0.0213353 0.665078 0.658739
Schistosoma mansoni diacylglycerol kinase theta 0.00276313 0.0212415 0.00271529
Schistosoma mansoni serine/threonine protein kinase 0.00276313 0.0212415 0.00271529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00818063 0.209048 0.339239
Onchocerca volvulus 0.00870706 0.227298 0.371742
Loa Loa (eye worm) tubulin alpha chain 0.0233635 0.735387 0.730378
Echinococcus granulosus tubulin alpha 0.0174383 0.529982 0.521086
Trichomonas vaginalis spcc417.12 protein, putative 0.00557244 0.118631 0.0643555
Loa Loa (eye worm) G-protein coupled receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus Tubulin beta 2C chain 0.0309965 1 1
Schistosoma mansoni rac gtpase activating protein 0.00276313 0.0212415 0.00271529
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.00390803 0.0609313 0.0431563
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.00868598 0.226567 0.211928
Schistosoma mansoni alpha tubulin 0.0233635 0.735387 0.730378
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.00276313 0.0212415 0.00271529
Brugia malayi Tachykinin-like peptides receptor 99D 0.00818063 0.209048 0.194077
Echinococcus multilocularis tubulin beta 1 chain 0.0309965 1 1
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Brugia malayi Dopamine receptor protein 2 0.00818063 0.209048 0.194077
Echinococcus granulosus protein kinase c epsilon type 0.0110098 0.307126 0.294011
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.00342408 0.0441544 0.0260619
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00818063 0.209048 0.194077
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.00969222 0.26145 0.247471
Echinococcus granulosus alpha tubulin 0.0233635 0.735387 0.730378
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Entamoeba histolytica protein kinase, putative 0.00390803 0.0609313 0.0405511
Loa Loa (eye worm) hypothetical protein 0.0153678 0.458204 0.447949
Trichomonas vaginalis tubulin, putative 0.00944268 0.2528 0.206786
Trypanosoma cruzi endonuclease G, putative 0.00519634 0.105593 0.100084
Brugia malayi Carboxylesterase family protein 0.00557244 0.118631 0.101948
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.00284743 0.0241639 0.00569301
Echinococcus granulosus tubulin alpha chain 0.0233635 0.735387 0.730378
Giardia lamblia Alpha-tubulin 0.0233635 0.735387 0.668141
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis neuropeptide receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis neuropeptides capa receptor 0.00818063 0.209048 0.194077
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.00557244 0.118631 0.0643555
Echinococcus granulosus neuropeptide receptor 0.00818063 0.209048 0.194077
Brugia malayi Carboxyl transferase domain containing protein 0.00342408 0.0441544 0.0260619
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00818063 0.209048 0.194077
Brugia malayi putative neuropeptide receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Mycobacterium tuberculosis Carboxylesterase LipT 0.0239782 0.756698 1
Toxoplasma gondii alpha-tubulin I, putative 0.0233635 0.735387 0.735387
Echinococcus granulosus somatostatin receptor 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus granulosus Rac GTPase activating protein 1 0.00276313 0.0212415 0.00271529
Schistosoma mansoni amine GPCR 0.00818063 0.209048 0.194077
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0309965 1 1
Loa Loa (eye worm) hypothetical protein 0.0205759 0.638751 0.631913
Toxoplasma gondii alpha tubulin TUBA1 0.0233635 0.735387 0.735387
Brugia malayi tubulin alpha chain - mouse 0.0233635 0.735387 0.730378
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00818063 0.209048 0.194077
Trypanosoma cruzi alpha tubulin, putative 0.0233635 0.735387 0.733757
Echinococcus granulosus serine:threonine protein kinase N2 0.00425126 0.0728301 0.0552804
Plasmodium falciparum cysteine repeat modular protein 1 0.00312409 0.0337547 0.0235362
Schistosoma mansoni tubulin subunit epsilon 0.0195887 0.60453 0.597044
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.00557244 0.118631 0.101948
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus multilocularis unc 13 (munc13) 0.0029348 0.0271928 0.0087793
Echinococcus granulosus g protein coupled receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus tm gpcr rhodopsin 0.00818063 0.209048 0.194077
Echinococcus multilocularis serine:threonine protein kinase 38 0.00390803 0.0609313 0.0431563
Brugia malayi Thrombospondin type 1 domain containing protein 0.0188824 0.580045 0.572096
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00818063 0.209048 0.194077
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Echinococcus granulosus serine:threonine protein kinase N2 0.00390803 0.0609313 0.0431563
Brugia malayi amidase 0.0113594 0.319245 0.306359
Treponema pallidum cell division protein FtsZ 0.00799564 0.202635 0.5
Schistosoma mansoni endonuclease related 0.00519634 0.105593 0.0886633
Loa Loa (eye worm) hypothetical protein 0.00870706 0.227298 0.212672
Leishmania major beta tubulin 0.0309965 1 1
Loa Loa (eye worm) hypothetical protein 0.00870706 0.227298 0.212672
Trichomonas vaginalis tubulin alpha chain, putative 0.00944268 0.2528 0.206786
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.00390803 0.0609313 0.0431563
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0153678 0.458204 0.42484
Trichomonas vaginalis tubulin, putative 0.0309965 1 1
Echinococcus granulosus myotubularin protein 13 0.00276313 0.0212415 0.00271529
Brugia malayi Protein kinase domain containing protein 0.00390803 0.0609313 0.0431563
Trichomonas vaginalis tubulin beta chain, putative 0.00944268 0.2528 0.206786
Echinococcus granulosus tubulin beta 4A class IVa 0.0309965 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.00350046 0.0468021 0.0468021
Trichomonas vaginalis tubulin epsilon chain, putative 0.0233635 0.735387 0.719092
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Brugia malayi beta-tubulin, identical 0.0309965 1 1
Echinococcus multilocularis sex peptide receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus orexin receptor type 2 0.00818063 0.209048 0.194077
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.00735457 0.180412 0.164898
Onchocerca volvulus 0.00818063 0.209048 0.339239
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Brugia malayi neuropeptide F receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni tubulin subunit beta 0.0309965 1 1
Brugia malayi Tubulin alpha-2 chain 0.0233635 0.735387 0.730378
Schistosoma mansoni serine/threonine protein kinase 0.0110098 0.307126 0.294011
Onchocerca volvulus 0.00818063 0.209048 0.339239
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin alpha 2 0.0153678 0.458204 0.447949
Schistosoma mansoni biogenic amine receptor 0.00818063 0.209048 0.194077
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni atypical protein kinase C 0.00667116 0.15672 0.140758
Onchocerca volvulus 0.00868598 0.226567 0.370441
Loa Loa (eye worm) tubulin beta-4 chain 0.0309965 1 1
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Loa Loa (eye worm) hypothetical protein 0.00868598 0.226567 0.211928
Brugia malayi diacylglycerol kinase 0.00276313 0.0212415 0.00271529
Trypanosoma brucei beta tubulin 0.0309965 1 1
Toxoplasma gondii beta-tubulin, putative 0.0309965 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni neuropeptide receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.0166679 0.503272 0.49387
Brugia malayi Tubulin alpha chain 0.00799564 0.202635 0.187543
Schistosoma mansoni serine/threonine protein kinase 0.00284743 0.0241639 0.00569301
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.00276313 0.0212415 0.00271529
Leishmania major acetyl-CoA carboxylase, putative 0.00350046 0.0468021 0.0135032
Echinococcus granulosus neuropeptide s receptor 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.0188824 0.580045 1
Schistosoma mansoni hypothetical protein 0.0188824 0.580045 0.572096
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.00519634 0.105593 0.105593
Echinococcus granulosus dro:myosuppressin receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin alpha 2 0.00592513 0.130857 0.114406
Echinococcus multilocularis somatostatin receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis Tubulin beta 2C chain 0.0309965 1 1
Leishmania major beta tubulin 0.0309965 1 1
Onchocerca volvulus 0.00818063 0.209048 0.339239
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus granulosus peroxisome assembly protein 26 0.0233635 0.735387 0.730378
Echinococcus granulosus neuropeptide FF receptor 2 0.00818063 0.209048 0.194077
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Echinococcus multilocularis fmrfamide receptor 0.00818063 0.209048 0.194077
Entamoeba histolytica protein kinase, putative 0.00390803 0.0609313 0.0405511
Trypanosoma cruzi zeta tubulin, putative 0.0300369 0.966734 0.966529
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) carboxylesterase 0.00557244 0.118631 0.101948
Echinococcus multilocularis g protein coupled receptor 0.00818063 0.209048 0.194077
Trichomonas vaginalis tubulin beta-1 chain, putative 0.00799564 0.202635 0.153533
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00276313 0.0212415 0.00474622
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.00276313 0.0212415 0.00271529
Toxoplasma gondii kringle domain-containing protein 0.00312409 0.0337547 0.0337547
Brugia malayi AKH receptor 0.00818063 0.209048 0.194077
Trypanosoma brucei epsilon tubulin 0.0195887 0.60453 0.585112
Brugia malayi G-protein coupled receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin alpha 1C chain 0.0233635 0.735387 0.730378
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0113594 0.319245 0.306359
Echinococcus multilocularis hypothetical protein 0.0233635 0.735387 0.730378
Echinococcus multilocularis carboxylesterase 5A 0.0213353 0.665078 0.658739
Schistosoma mansoni fatty-acid amide hydrolase 0.0113594 0.319245 0.306359
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Mycobacterium leprae cell division protein FtsZ 0.00799564 0.202635 0.5
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00735457 0.180412 0.164898
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni diacylglycerol kinase theta 0.00276313 0.0212415 0.00271529
Trypanosoma brucei endonuclease G, putative 0.00519634 0.105593 0.0616773
Echinococcus granulosus acetylcholinesterase 0.0213353 0.665078 0.658739
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Schistosoma mansoni amine GPCR 0.00818063 0.209048 0.194077
Brugia malayi Carboxylesterase family protein 0.00557244 0.118631 0.101948
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis g protein coupled receptor 0.00818063 0.209048 0.194077
Brugia malayi Lipase family protein 0.0120321 0.342566 0.330122
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00557244 0.118631 0.101948
Trypanosoma brucei endonuclease G, putative 0.00519634 0.105593 0.0616773
Echinococcus multilocularis raf serine:threonine protein kinase 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis N chimaerin 0.00276313 0.0212415 0.00271529
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.00799564 0.202635 0.5
Brugia malayi tubulin alpha-2 chain 0.0233635 0.735387 0.730378
Schistosoma mansoni tubulin subunit beta 0.00799564 0.202635 0.187543
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Schistosoma mansoni unc-13 (munc13) 0.0029348 0.0271928 0.0087793
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Onchocerca volvulus 0.0060208 0.134174 0.205885
Schistosoma mansoni hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis Tubulin alpha 1 chain 0.0233635 0.735387 0.730378
Schistosoma mansoni adenoreceptor 0.00818063 0.209048 0.194077
Entamoeba histolytica tubulin family protein 0.0309965 1 1
Brugia malayi Carboxylesterase family protein 0.0213353 0.665078 0.658739
Trichomonas vaginalis tubulin epsilon chain, putative 0.0233635 0.735387 0.719092
Echinococcus granulosus Protein kinase C brain isozyme 0.016535 0.498669 0.489179
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Schistosoma mansoni opsin-like receptor 0.00818063 0.209048 0.194077
Trypanosoma brucei zeta tubulin, putative 0.0300369 0.966734 0.965101
Trypanosoma brucei alpha tubulin 0.0233635 0.735387 0.722395
Schistosoma mansoni myosin xvIII 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin alpha chain 0.0233635 0.735387 0.730378
Leishmania major gamma-tubulin 0.019624 0.605754 0.591981
Brugia malayi Ras association domain family 1 isoform A 0.00276313 0.0212415 0.00271529
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Leishmania major beta tubulin 0.0309965 1 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.00284743 0.0241639 0.00569301
Echinococcus multilocularis Tubulin beta 2C chain 0.0309965 1 1
Echinococcus granulosus G protein coupled receptor 139 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00557244 0.118631 0.178201
Trypanosoma cruzi hypothetical protein, conserved 0.00312409 0.0337547 0.0278032
Giardia lamblia Epsilon tubulin 0.010146 0.277183 0.093492
Echinococcus granulosus BC026374 protein S09 family 0.00557244 0.118631 0.101948
Schistosoma mansoni biogenic amine receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin delta chain 0.00799564 0.202635 0.187543
Trypanosoma brucei epsilon tubulin 0.0174383 0.529982 0.506904
Brugia malayi p70 ribosomal S6 kinase beta 0.00390803 0.0609313 0.0431563
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0120321 0.342566 0.330122
Trichomonas vaginalis tubulin, putative 0.0101813 0.278407 0.23397
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Trypanosoma cruzi beta tubulin, putative 0.0309965 1 1
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus granulosus N chimaerin 0.00276313 0.0212415 0.00271529
Giardia lamblia Beta tubulin 0.0309965 1 1
Loa Loa (eye worm) hypothetical protein 0.0166679 0.503272 0.49387
Brugia malayi RhoGAP domain containing protein 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Onchocerca volvulus 0.00276313 0.0212415 0.00474622
Schistosoma mansoni tubulin subunit beta 0.0309965 1 1
Echinococcus multilocularis beta tubulin 0.0309965 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni vav2 0.00276313 0.0212415 0.00271529
Echinococcus granulosus neuroligin 0.00557244 0.118631 0.101948
Brugia malayi Tubulin beta chain 0.00799564 0.202635 0.187543
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0212321 0.661501 0.661501
Onchocerca volvulus 0.00818063 0.209048 0.339239
Plasmodium vivax tubulin beta chain, putative 0.0309965 1 1
Schistosoma mansoni acetylcholinesterase 0.00557244 0.118631 0.101948
Trypanosoma brucei alpha tubulin, putative 0.00944268 0.2528 0.216112
Echinococcus granulosus RNA directed DNA polymerase 0.00969222 0.26145 0.247471
Loa Loa (eye worm) hypothetical protein 0.00868598 0.226567 0.211928
Schistosoma mansoni serine/threonine protein kinase 0.016535 0.498669 0.489179
Mycobacterium ulcerans carboxylesterase, LipT 0.0239782 0.756698 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Entamoeba histolytica PH domain containing protein kinase, putative 0.00425126 0.0728301 0.0527082
Echinococcus multilocularis tubulin alpha chain 0.0233635 0.735387 0.730378
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus multilocularis neuropeptide s receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin alpha-3 chain 0.0139208 0.40804 0.396835
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00818063 0.209048 0.194077
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.00350046 0.0468021 0.0468021
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0153678 0.458204 0.447949
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus biogenic amine 5HT receptor 0.00818063 0.209048 0.194077
Entamoeba histolytica tubulin alpha chain, putative 0.0233635 0.735387 0.729644
Schistosoma mansoni serine/threonine protein kinase 0.00284743 0.0241639 0.00569301
Echinococcus multilocularis fmrfamide receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni amine GPCR 0.00818063 0.209048 0.194077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00818063 0.209048 0.194077
Schistosoma mansoni protein kinase C 0.0029348 0.0271928 0.0087793
Plasmodium falciparum alpha tubulin 2 0.0233635 0.735387 0.732589
Schistosoma mansoni neuropeptide f receptor 76f 0.00818063 0.209048 0.194077
Trypanosoma cruzi zeta tubulin, putative 0.0300369 0.966734 0.966529
Brugia malayi Tubulin beta chain 0.00944268 0.2528 0.238657
Brugia malayi Protein kinase domain containing protein 0.00312409 0.0337547 0.0154654
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00818063 0.209048 0.194077
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Trichomonas vaginalis tubulin beta chain, putative 0.0233635 0.735387 0.719092
Loa Loa (eye worm) TYRA-2 protein 0.00818063 0.209048 0.194077
Echinococcus granulosus tm gpcr rhodopsin 0.00818063 0.209048 0.194077
Echinococcus granulosus 7tm_1 domain containing protein 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin alpha chain 0.0233635 0.735387 0.730378
Brugia malayi Pleckstrin Homology Domain 0.00276313 0.0212415 0.00271529
Plasmodium vivax tubulin gamma chain, putative 0.019624 0.605754 0.601585
Trypanosoma brucei alpha tubulin 0.0233635 0.735387 0.722395
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00818063 0.209048 0.194077
Trypanosoma brucei beta tubulin 0.0309965 1 1
Plasmodium vivax tubulin epsilon chain, putative 0.0195887 0.60453 0.600347
Echinococcus granulosus tubulin alpha chain 0.0233635 0.735387 0.730378
Brugia malayi hypothetical protein 0.00557244 0.118631 0.101948
Echinococcus granulosus neuropeptide receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni tubulin subunit beta 0.0309965 1 1
Onchocerca volvulus 0.00557244 0.118631 0.178201
Schistosoma mansoni tubulin subunit beta 0.0309965 1 1
Brugia malayi alpha-tubulin 0.0233635 0.735387 0.730378
Loa Loa (eye worm) TK/ROR protein kinase 0.00312409 0.0337547 0.0154654
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Brugia malayi G-protein coupled receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.00284743 0.0241639 0.00569301
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Brugia malayi Carboxylesterase family protein 0.0213353 0.665078 0.658739
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Trypanosoma brucei beta tubulin 0.0174383 0.529982 0.506904
Schistosoma mansoni serine/threonine protein kinase 0.00390803 0.0609313 0.0431563
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni BC026374 protein (S09 family) 0.00557244 0.118631 0.101948
Trichomonas vaginalis tubulin gamma chain, putative 0.0195887 0.60453 0.580176
Leishmania major beta tubulin 0.0309965 1 1
Schistosoma mansoni tubulin subunit alpha 0.0233635 0.735387 0.730378
Schistosoma mansoni tubulin subunit gamma 0.019624 0.605754 0.598292
Schistosoma mansoni hypothetical protein 0.00276313 0.0212415 0.00271529
Giardia lamblia Gamma tubulin 0.019624 0.605754 0.505564
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00818063 0.209048 0.194077
Trichomonas vaginalis tubulin beta chain, putative 0.0233635 0.735387 0.719092
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis tubulin epsilon chain 0.0195887 0.60453 0.597044
Echinococcus multilocularis Tubulin beta 2C chain 0.0309965 1 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.00868598 0.226567 0.211928
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.00390803 0.0609313 0.0431563
Trypanosoma cruzi tubulin gamma chain 0.019624 0.605754 0.603326
Echinococcus granulosus NDR protein kinase 0.00390803 0.0609313 0.0431563
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00818063 0.209048 0.194077
Brugia malayi Protein kinase domain containing protein 0.00284743 0.0241639 0.00569301
Trichomonas vaginalis tubulin gamma chain, putative 0.019624 0.605754 0.581476
Brugia malayi sulfakinin receptor protein 0.00818063 0.209048 0.194077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00818063 0.209048 0.194077
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Echinococcus multilocularis dro:myosuppressin receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00557244 0.118631 0.101948
Echinococcus granulosus Tubulin beta 2C chain 0.0309965 1 1
Echinococcus granulosus serotonin receptor 0.00818063 0.209048 0.194077
Brugia malayi putative neuropeptide receptor NPR1 0.00818063 0.209048 0.194077
Entamoeba histolytica tubulin family protein 0.0309965 1 1
Loa Loa (eye worm) BEN-1 protein 0.0309965 1 1
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus Tubulin alpha 1 chain 0.0233635 0.735387 0.730378
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00818063 0.209048 0.194077
Echinococcus multilocularis neuropeptide FF receptor 2 0.00818063 0.209048 0.194077
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.00868598 0.226567 0.211928
Echinococcus multilocularis protein kinase c iota type 0.00667116 0.15672 0.140758
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Echinococcus multilocularis allatostatin A receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) alpha-tubulin 0.0233635 0.735387 0.730378
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00818063 0.209048 0.194077
Echinococcus granulosus Endonuclease G 0.00519634 0.105593 0.0886633
Onchocerca volvulus 0.0166679 0.503272 0.863265
Schistosoma mansoni hypothetical protein 0.00312409 0.0337547 0.0154654
Loa Loa (eye worm) hypothetical protein 0.019431 0.599061 0.591472
Onchocerca volvulus 0.00818063 0.209048 0.339239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00818063 0.209048 0.194077
Trichomonas vaginalis tubulin gamma chain, putative 0.0309965 1 1
Toxoplasma gondii beta-1 tubulin, putative 0.0309965 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.00807499 0.205386 0.190345
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Plasmodium falciparum tubulin epsilon chain, putative 0.0195887 0.60453 0.600347
Schistosoma mansoni hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) AGC/AKT protein kinase 0.00390803 0.0609313 0.0431563
Schistosoma mansoni biogenic amine (5HT) receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus Tubulin alpha 1 chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) tubulin beta chain 0.0309965 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00818063 0.209048 0.339239
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin beta-1 chain 0.0309965 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00818063 0.209048 0.194077
Brugia malayi C1-like domain containing protein 0.00284743 0.0241639 0.00569301
Schistosoma mansoni tubulin subunit alpha 0.0233635 0.735387 0.730378
Echinococcus granulosus hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00818063 0.209048 0.194077
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.00868598 0.226567 0.211928
Schistosoma mansoni serine/threonine kinase 0.00390803 0.0609313 0.0431563
Onchocerca volvulus 0.00557244 0.118631 0.178201
Onchocerca volvulus 0.00312409 0.0337547 0.0270329
Echinococcus granulosus neuropeptide Y receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.0029348 0.0271928 0.0087793
Echinococcus multilocularis tubulin subunit TubB 0.0233635 0.735387 0.730378
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.00944268 0.2528 0.206786
Echinococcus granulosus neuropeptides capa receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis tubulin alpha chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Brugia malayi diacylglycerol kinase 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis tubulin alpha 1C chain 0.0233635 0.735387 0.730378
Onchocerca volvulus 0.00868598 0.226567 0.370441
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Brugia malayi protein kinase C II. 0.0110098 0.307126 0.294011
Loa Loa (eye worm) neuropeptide F receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis acetylcholinesterase 0.0213353 0.665078 0.658739
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.00390803 0.0609313 0.0431563
Onchocerca volvulus 0.00818063 0.209048 0.339239
Schistosoma mansoni tubulin subunit alpha 0.0233635 0.735387 0.730378
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) RasGEF domain-containing protein 0.00276313 0.0212415 0.00271529
Brugia malayi G protein-coupled receptor F59B2.13 0.00818063 0.209048 0.194077
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00818063 0.209048 0.194077
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.00519634 0.105593 0.0743477
Brugia malayi Protein kinase domain containing protein 0.00390803 0.0609313 0.0431563
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus unc 13 munc13 0.0029348 0.0271928 0.0087793
Echinococcus multilocularis peroxisome assembly protein 26 0.0233635 0.735387 0.730378
Brugia malayi Serotonin receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin beta 1 chain 0.0309965 1 1
Echinococcus granulosus tubulin epsilon chain 0.0195887 0.60453 0.597044
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Brugia malayi endonuclease G, mitochondrial precursor 0.00519634 0.105593 0.0886633
Schistosoma mansoni serine/threonine protein kinase 0.00390803 0.0609313 0.0431563
Schistosoma mansoni serine/threonine protein kinase 0.00390803 0.0609313 0.0431563
Schistosoma mansoni tubulin subunit beta 0.0309965 1 1
Onchocerca volvulus 0.00818063 0.209048 0.339239
Plasmodium falciparum alpha tubulin 1 0.0233635 0.735387 0.732589
Leishmania major beta tubulin 0.0309965 1 1
Schistosoma mansoni alpha tubulin 0.0233635 0.735387 0.730378
Mycobacterium tuberculosis Cell division protein FtsZ 0.00799564 0.202635 0.131654
Echinococcus multilocularis BC026374 protein (S09 family) 0.00557244 0.118631 0.101948
Schistosoma mansoni gliotactin 0.00557244 0.118631 0.101948
Loa Loa (eye worm) melatonin receptor type 1A 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus granulosus zinc finger transcription factor gli2 0.0219538 0.686519 0.680586
Trichomonas vaginalis tubulin gamma chain, putative 0.00799564 0.202635 0.153533
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.00350046 0.0468021 0.0287598
Echinococcus multilocularis tubulin alpha 0.0174383 0.529982 0.521086
Echinococcus multilocularis Tubulin beta 2C chain 0.0309965 1 1
Trypanosoma brucei alpha tubulin 0.0233635 0.735387 0.722395
Brugia malayi Carboxylesterase family protein 0.00557244 0.118631 0.101948
Brugia malayi protein kinase C3,putative 0.00284743 0.0241639 0.00569301
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00818063 0.209048 0.194077
Trypanosoma brucei lipase domain protein, putative 0.0120321 0.342566 0.310286
Trypanosoma cruzi hypothetical protein, conserved 0.0120321 0.342566 0.338517
Schistosoma mansoni neuroligin 3 (S09 family) 0.00557244 0.118631 0.101948
Schistosoma mansoni neuropeptide receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.00390803 0.0609313 0.0431563
Brugia malayi Tubulin gamma chain 0.019624 0.605754 0.598292
Loa Loa (eye worm) hypothetical protein 0.0166679 0.503272 0.49387
Leishmania major beta tubulin 0.0309965 1 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0110098 0.307126 0.294011
Echinococcus multilocularis para nitrobenzyl esterase 0.00557244 0.118631 0.101948
Loa Loa (eye worm) AGC/NDR protein kinase 0.00390803 0.0609313 0.0431563
Echinococcus granulosus beta tubulin 0.0309965 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0233635 0.735387 0.719092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00818063 0.209048 0.194077
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.010146 0.277183 0.277183
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin subunit beta 0.0309965 1 1
Schistosoma mansoni amine GPCR 0.00818063 0.209048 0.194077
Onchocerca volvulus Neuropeptide F receptor homolog 0.00818063 0.209048 0.339239
Loa Loa (eye worm) tubulin gamma chain 0.019624 0.605754 0.598292
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Trypanosoma cruzi epsilon tubulin, putative 0.0195887 0.60453 0.602094
Echinococcus granulosus 7TM GPCR rhodopsin 0.00818063 0.209048 0.194077
Schistosoma mansoni tubulin subunit beta 0.0309965 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.00818063 0.209048 0.194077
Echinococcus granulosus fatty acid amide hydrolase 1 0.0113594 0.319245 0.306359
Echinococcus multilocularis orexin receptor type 2 0.00818063 0.209048 0.194077
Brugia malayi Tubulin beta-1 chain 0.0309965 1 1
Onchocerca volvulus 0.00818063 0.209048 0.339239
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni serine/threonine protein kinase 0.00390803 0.0609313 0.0431563
Brugia malayi Dopamine receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.00994819 0.270324 0.256512
Echinococcus multilocularis Tubulin alpha 1 chain 0.0233635 0.735387 0.730378
Schistosoma mansoni neuropeptide receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus Tubulin beta 2C chain 0.0309965 1 1
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Loa Loa (eye worm) beta-tubulin 0.0309965 1 1
Echinococcus multilocularis g protein coupled receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus neuropeptide Y receptor 0.00818063 0.209048 0.194077
Brugia malayi larval opioid receptor 0.00818063 0.209048 0.194077
Plasmodium vivax tubulin alpha chain, putative 0.0233635 0.735387 0.732589
Loa Loa (eye worm) tubulin beta chain 0.00799564 0.202635 0.187543
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.00390803 0.0609313 0.0431563
Schistosoma mansoni biogenic amine (5HT) receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Echinococcus granulosus beta tubulin 0.0309965 1 1
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Loa Loa (eye worm) hypothetical protein 0.0139208 0.40804 0.396835
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.00390803 0.0609313 0.0431563
Echinococcus multilocularis protein kinase c eta type 0.00276313 0.0212415 0.00271529
Onchocerca volvulus 0.00557244 0.118631 0.178201
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Schistosoma mansoni tubulin subunit alpha 0.00799564 0.202635 0.187543
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00818063 0.209048 0.194077
Leishmania major epsilon tubulin, putative 0.0195887 0.60453 0.590714
Onchocerca volvulus 0.00818063 0.209048 0.339239
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Schistosoma mansoni protein kinase C mu 0.00284743 0.0241639 0.00569301
Loa Loa (eye worm) hypothetical protein 0.0124553 0.357239 0.345073
Trichomonas vaginalis conserved hypothetical protein 0.00799564 0.202635 0.153533
Echinococcus multilocularis Rac GTPase activating protein 1 0.00276313 0.0212415 0.00271529
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Trichomonas vaginalis tubulin alpha chain, putative 0.00944268 0.2528 0.206786
Trichomonas vaginalis tubulin beta chain, putative 0.0233635 0.735387 0.719092
Loa Loa (eye worm) acetylcholinesterase 1 0.0213353 0.665078 0.658739
Brugia malayi ORL1-like opioid receptor 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus multilocularis tubulin gamma 1 chain 0.019624 0.605754 0.598292
Trypanosoma cruzi epsilon tubulin, putative 0.0195887 0.60453 0.602094
Trypanosoma cruzi tubulin delta chain 0.0212321 0.661501 0.659416
Echinococcus granulosus tachykinin peptides receptor 99D 0.00818063 0.209048 0.194077
Schistosoma mansoni amidase 0.0113594 0.319245 0.306359
Brugia malayi Protein kinase domain containing protein 0.00390803 0.0609313 0.0431563
Brugia malayi neuropeptide F receptor 0.00818063 0.209048 0.194077
Brugia malayi Carboxylesterase family protein 0.00557244 0.118631 0.101948
Leishmania major endonuclease G, putative 0.00519634 0.105593 0.0743477
Echinococcus granulosus alpha 1A adrenergic receptor 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00818063 0.209048 0.339239
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.00868598 0.226567 0.211928
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00557244 0.118631 0.101948
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.00284743 0.0241639 0.00569301
Trypanosoma brucei zeta tubulin 0.0300369 0.966734 0.965101
Brugia malayi Dopamine receptor protein 1 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.00390803 0.0609313 0.0431563
Loa Loa (eye worm) tubulin alpha 2 0.0153678 0.458204 0.447949
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0113594 0.319245 0.306359
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0193765 0.597173 0.589548
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Echinococcus granulosus para nitrobenzyl esterase 0.00557244 0.118631 0.101948
Echinococcus multilocularis RNA directed DNA polymerase 0.00969222 0.26145 0.247471
Echinococcus granulosus tm gpcr rhodopsin 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus fatty acid amide hydrolase 1 0.0113594 0.319245 0.306359
Entamoeba histolytica tubulin alpha-1 chain 0.0233635 0.735387 0.729644
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0174383 0.529982 0.529982
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0213353 0.665078 0.658739
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Loa Loa (eye worm) RhoGAP domain-containing protein 0.00276313 0.0212415 0.00271529
Echinococcus granulosus Diacylglycerol kinase theta 0.00276313 0.0212415 0.00271529
Trichomonas vaginalis tubulin, putative 0.00944268 0.2528 0.206786
Echinococcus granulosus family S9 non peptidase ue S09 family 0.00557244 0.118631 0.101948
Echinococcus granulosus Tubulin alpha 1 chain 0.0233635 0.735387 0.730378
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis tubulin alpha chain 0.0233635 0.735387 0.730378
Echinococcus multilocularis Tubulin beta 2C chain 0.0309965 1 1
Trichomonas vaginalis conserved hypothetical protein 0.00799564 0.202635 0.153533
Schistosoma mansoni amine GPCR 0.00818063 0.209048 0.194077
Trichomonas vaginalis lipase containing protein, putative 0.0120321 0.342566 0.30208
Loa Loa (eye worm) alpha-tubulin 0.0233635 0.735387 0.730378
Echinococcus granulosus Tubulin beta 2C chain 0.0309965 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) variant SH3 domain-containing protein 0.00276313 0.0212415 0.00271529
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.00868598 0.226567 0.211928
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis tubulin alpha chain 0.0233635 0.735387 0.730378
Schistosoma mansoni unc-13 (munc13) 0.0029348 0.0271928 0.0087793
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.00519634 0.105593 0.100084
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0029348 0.0271928 0.0087793
Echinococcus multilocularis neuropeptides capa receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00735457 0.180412 0.164898
Trypanosoma cruzi endonuclease G, putative 0.00519634 0.105593 0.100084
Schistosoma mansoni opsin-like receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00312409 0.0337547 0.0154654
Plasmodium falciparum tubulin beta chain 0.0309965 1 1
Schistosoma mansoni hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus allatostatin A receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00818063 0.209048 0.194077
Echinococcus granulosus peptide allatostatin:somatostatin 0.00818063 0.209048 0.194077
Echinococcus multilocularis zinc finger transcription factor gli2 0.0219538 0.686519 0.680586
Echinococcus granulosus ectonucleotide 0.00735457 0.180412 0.164898
Echinococcus granulosus tubulin alpha 3 chain 0.0233635 0.735387 0.730378
Trichomonas vaginalis tubulin alpha chain, putative 0.0309965 1 1
Echinococcus granulosus tubulin subunit TubB 0.0233635 0.735387 0.730378
Echinococcus multilocularis serotonin receptor 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00818063 0.209048 0.339239
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0188824 0.580045 0.572096
Giardia lamblia Alpha-tubulin 0.0233635 0.735387 0.668141
Trypanosoma cruzi tubulin delta chain 0.0212321 0.661501 0.659416
Loa Loa (eye worm) hypothetical protein 0.00557244 0.118631 0.101948
Echinococcus granulosus tubulin alpha chain 0.0233635 0.735387 0.730378
Plasmodium falciparum tubulin delta chain, putative 0.00799564 0.202635 0.194203
Echinococcus granulosus protein kinase C gamma type 0.0137719 0.40288 0.391578
Echinococcus multilocularis neuropeptide receptor 0.00818063 0.209048 0.194077
Trypanosoma brucei beta tubulin 0.0309965 1 1
Plasmodium vivax delta tubulin, putative 0.00799564 0.202635 0.194203
Entamoeba histolytica protein kinase, putative 0.00390803 0.0609313 0.0405511
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.0113594 0.319245 0.306359
Echinococcus granulosus tubulin alpha 1C chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) hypothetical protein 0.0213353 0.665078 0.658739
Echinococcus multilocularis Protein kinase C, brain isozyme 0.016535 0.498669 0.489179
Trypanosoma brucei endonuclease G, putative 0.00519634 0.105593 0.0616773
Loa Loa (eye worm) hypothetical protein 0.00276313 0.0212415 0.00271529
Echinococcus granulosus protein kinase c iota type 0.00667116 0.15672 0.140758
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.00390803 0.0609313 0.0431563
Echinococcus multilocularis neuroligin 0.00557244 0.118631 0.101948
Echinococcus granulosus sex peptide receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.00519634 0.105593 0.100084
Brugia malayi Zinc finger, C2H2 type family protein 0.0219538 0.686519 0.680586
Loa Loa (eye worm) hypothetical protein 0.00868598 0.226567 0.211928
Plasmodium falciparum tubulin gamma chain 0.019624 0.605754 0.601585
Echinococcus multilocularis tubulin alpha chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni neuropeptide F-like receptor 0.00818063 0.209048 0.194077
Leishmania major beta tubulin 0.0309965 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00870706 0.227298 0.212672
Brugia malayi Tubulin alpha-2 chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) lipase 0.0120321 0.342566 0.330122
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Loa Loa (eye worm) carboxylesterase 0.00557244 0.118631 0.101948
Schistosoma mansoni neuropeptide F-like receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.0213353 0.665078 0.658739
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Schistosoma mansoni opsin-like receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00818063 0.209048 0.194077
Loa Loa (eye worm) tubulin beta-2A chain 0.0309965 1 1
Toxoplasma gondii diacylglycerol kinase, putative 0.00276313 0.0212415 0.0212415
Trypanosoma cruzi hypothetical protein, conserved 0.0120321 0.342566 0.338517
Toxoplasma gondii AGC kinase 0.00390803 0.0609313 0.0609313
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0139208 0.40804 0.371587
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Loa Loa (eye worm) hypothetical protein 0.0233635 0.735387 0.730378
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00818063 0.209048 0.194077
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.00284743 0.0241639 0.00569301
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus multilocularis rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Trichomonas vaginalis tubulin beta chain, putative 0.0233635 0.735387 0.719092
Trichomonas vaginalis tubulin alpha chain, putative 0.0174383 0.529982 0.501038
Echinococcus granulosus rhodopsin orphan GPCR 0.00818063 0.209048 0.194077
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Plasmodium vivax tubulin alpha chain, putative 0.0233635 0.735387 0.732589
Giardia lamblia Beta tubulin 0.0309965 1 1
Echinococcus multilocularis protein kinase c epsilon type 0.0110098 0.307126 0.294011
Echinococcus multilocularis neuropeptide receptor A26 0.00818063 0.209048 0.194077
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00870706 0.227298 0.212672
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Echinococcus granulosus biogenic amine 5HT receptor 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00818063 0.209048 0.339239
Onchocerca volvulus 0.00944268 0.2528 0.417162
Trypanosoma brucei tubulin delta chain 0.0212321 0.661501 0.64488
Giardia lamblia Beta tubulin 0.0309965 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus fmrfamide receptor 0.00818063 0.209048 0.194077
Brugia malayi Cell division protein ftsZ 0.00799564 0.202635 0.187543
Echinococcus multilocularis tubulin alpha 3 chain 0.0233635 0.735387 0.730378
Trichomonas vaginalis AGC family protein kinase 0.00390803 0.0609313 0.00310237
Onchocerca volvulus 0.00818063 0.209048 0.339239
Trypanosoma brucei alpha tubulin 0.0233635 0.735387 0.722395
Schistosoma mansoni histamine h1 receptor 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.0120321 0.342566 0.577039
Leishmania major delta tubulin, putative 0.0212321 0.661501 0.649675
Trypanosoma brucei beta tubulin 0.0309965 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.00944268 0.2528 0.206786
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.00390803 0.0609313 0.0431563
Echinococcus multilocularis acetylcholinesterase 0.0213353 0.665078 0.658739
Echinococcus multilocularis G protein coupled receptor 139 0.00818063 0.209048 0.194077
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis g-protein coupled receptor 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00818063 0.209048 0.339239
Loa Loa (eye worm) AGC/PKN protein kinase 0.00390803 0.0609313 0.0431563
Echinococcus multilocularis ectonucleotide 0.00735457 0.180412 0.164898
Brugia malayi Kringle domain containing protein 0.00312409 0.0337547 0.0154654
Entamoeba histolytica tubulin gamma chain 0.019624 0.605754 0.597198
Brugia malayi Tubulin alpha chain 0.0233635 0.735387 0.730378
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.00350046 0.0468021 0.0287598
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus tubulin alpha chain 0.0233635 0.735387 0.730378
Loa Loa (eye worm) BEN-1 protein 0.0309965 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0309965 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.00818063 0.209048 0.194077
Echinococcus multilocularis myotubularin protein 13 0.00276313 0.0212415 0.00271529
Echinococcus granulosus neuropeptides capa receptor 0.00818063 0.209048 0.194077
Echinococcus granulosus acetylcholinesterase 0.0213353 0.665078 0.658739
Echinococcus granulosus raf serine:threonine protein kinase 0.00276313 0.0212415 0.00271529
Trypanosoma brucei tubulin gamma chain 0.019624 0.605754 0.586396
Loa Loa (eye worm) hypothetical protein 0.00818063 0.209048 0.194077
Trypanosoma brucei epsilon tubulin 0.0195887 0.60453 0.585112
Brugia malayi hypothetical protein 0.00818063 0.209048 0.194077
Leishmania major zeta tubulin, putative 0.0300369 0.966734 0.965572
Brugia malayi RE15519p 0.00818063 0.209048 0.194077
Echinococcus multilocularis Tubulin alpha 1 chain 0.0233635 0.735387 0.730378
Trichomonas vaginalis tubulin epsilon chain, putative 0.00799564 0.202635 0.153533
Onchocerca volvulus 0.0029348 0.0271928 0.0153458
Onchocerca volvulus 0.00818063 0.209048 0.339239
Echinococcus multilocularis tubulin subunit beta 0.0309965 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0309965 1 1
Loa Loa (eye worm) zinc finger protein 0.0219538 0.686519 0.680586
Schistosoma mansoni biogenic amine receptor 0.00818063 0.209048 0.194077
Brugia malayi RhoGAP domain containing protein 0.00276313 0.0212415 0.00271529
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0233635 0.735387 0.719092
Onchocerca volvulus 0.00557244 0.118631 0.178201
Echinococcus granulosus g protein coupled receptor 0.00818063 0.209048 0.194077
Brugia malayi Serotonin receptor 0.00818063 0.209048 0.194077
Entamoeba histolytica protein kinase, putative 0.00390803 0.0609313 0.0405511
Echinococcus granulosus neuropeptide receptor A26 0.00818063 0.209048 0.194077
Echinococcus granulosus tissue type plasminogen activator 0.00312409 0.0337547 0.0154654
Echinococcus granulosus g protein coupled receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni protein kinase C mu 0.00276313 0.0212415 0.00271529
Loa Loa (eye worm) raf kinase 0.00276313 0.0212415 0.00271529
Brugia malayi Hr1 repeat family protein 0.00390803 0.0609313 0.0431563
Trichomonas vaginalis lipase containing protein, putative 0.0120321 0.342566 0.30208
Schistosoma mansoni acetyl-CoA carboxylase 0.00350046 0.0468021 0.0287598
Echinococcus multilocularis tissue type plasminogen activator 0.00312409 0.0337547 0.0154654
Brugia malayi Variant SH3 domain containing protein 0.00276313 0.0212415 0.00271529
Brugia malayi G protein-coupled receptor 0.00818063 0.209048 0.194077
Toxoplasma gondii beta tubulin 0.0309965 1 1
Leishmania major alpha tubulin 0.0233635 0.735387 0.726143
Brugia malayi Trypsin family protein 0.00870706 0.227298 0.212672
Echinococcus multilocularis serotonin receptor 0.00818063 0.209048 0.194077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00818063 0.209048 0.194077
Onchocerca volvulus 0.00818063 0.209048 0.339239
Brugia malayi RhoGEF domain containing protein 0.00276313 0.0212415 0.00271529
Echinococcus multilocularis beta tubulin 0.0309965 1 1
Schistosoma mansoni alpha tubulin 0.0233635 0.735387 0.730378
Leishmania major beta tubulin 0.0309965 1 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1 ug ml-1 Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 5 ug ml-1 Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 5.9 ug ml-1 Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 6.9 ug ml-1 Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 7.3 ug ml-1 Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 11.1 ug ml-1 Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 11.1 ug ml-1 Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 11.8 ug ml-1 Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
ED50 (functional) = 12.9 ug ml-1 Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay ChEMBL. 8229020
IC50 (functional) = 5.42 ug ml-1 Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 19299148
IC50 (functional) > 10 uM Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay ChEMBL. 20550100
IC50 (functional) > 10 uM Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay ChEMBL. 20550100
IC50 (functional) > 10 uM Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay ChEMBL. 20550100
IC50 (functional) > 10 uM Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay ChEMBL. 23190013
Ki (binding) Inhibition of AChE at 10 uM by Ellman's assay ChEMBL. 20655219

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 19299148
Mus musculus ChEMBL23 20550100
Homo sapiens ChEMBL23 20550100

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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