Detailed information for compound 576217

Basic information

Technical information
  • TDR Targets ID: 576217
  • Name: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-bromo-2 -(hydroxymethyl)tetrahydrofuran-3-ol
  • MW: 330.138 | Formula: C10H12BrN5O3
  • H donors: 3 H acceptors: 5 LogP: -0.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)Br)n1cnc2c1ncnc2N
  • InChi: 1S/C10H12BrN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1
  • InChiKey: SBSSUAKDMQSKOH-QYYRPYCUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-bromo-2-(hydroxymethyl)-3-tetrahydrofuranol
  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-bromo-2-(hydroxymethyl)oxolan-3-ol
  • (2R,3R,4R,5R)-5-adenin-9-yl-4-bromo-2-methylol-tetrahydrofuran-3-ol
  • 2'-bromo-2'-deoxyadenosine
  • (2R,3R,4R,5R)-5-(6-amino-9-purinyl)-4-bromo-2-(hydroxymethyl)-3-tetrahydrofuranol
  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-bromo-2-methylol-tetrahydrofuran-3-ol
  • 2'-Deoxy-2'-bromoadenosine
  • 2-Dabr
  • Adenosine, 2'-bromo-2'-deoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum glutathione reductase 0.0046 0.0328 1
Schistosoma mansoni patched 1 0.0044 0.031 0.0575
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0039 0.0066
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2385 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0895 0.1476
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.001 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0125 0.1196 0.5013
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.1819 0.305
Plasmodium vivax SET domain protein, putative 0.0031 0.0161 0.248
Schistosoma mansoni bromodomain containing protein 0.0066 0.0544 0.1009
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0103 0.0956 0.4008
Onchocerca volvulus 0.0046 0.0332 0.0327
Onchocerca volvulus 0.0509 0.5391 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0509 0.0828
Brugia malayi CHE-14 protein 0.0044 0.031 0.052
Brugia malayi glutathione reductase 0.0046 0.0328 0.0549
Echinococcus multilocularis cpg binding protein 0.0065 0.0534 0.0895
Onchocerca volvulus 0.0075 0.065 0.0934
Schistosoma mansoni cpg binding protein 0.0065 0.0534 0.0991
Schistosoma mansoni mannosidase alpha class 2a 0.0098 0.0895 0.166
Echinococcus multilocularis neutral alpha glucosidase AB 0.0125 0.1196 0.2004
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1098 0.1098
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0125 0.1196 0.1982
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0477 0.0774
Trichomonas vaginalis esterase, putative 0.0075 0.065 0.2724
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0125 0.1196 0.5013
Loa Loa (eye worm) hypothetical protein 0.0304 0.3152 0.5272
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0954 0.1599
Brugia malayi CXXC zinc finger family protein 0.0059 0.0477 0.0799
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.065 0.2724
Loa Loa (eye worm) hypothetical protein 0.0046 0.0332 0.0531
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0077 0.0582
Brugia malayi Pre-SET motif family protein 0.0206 0.2076 0.348
Schistosoma mansoni alpha-glucosidase 0.0509 0.5391 1
Plasmodium vivax hypothetical protein, conserved 0.0075 0.065 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0161 0.0299
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.097 0.097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0341 0.0572
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0621 0.2606
Schistosoma mansoni hypothetical protein 0.0281 0.2901 0.5381
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0956 0.4008
Schistosoma mansoni hypothetical protein 0.0043 0.0293 0.0543
Trichomonas vaginalis alpha-glucosidase, putative 0.0125 0.1196 0.5013
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0039 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0125 0.1196 0.2004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.065 0.1065
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Plasmodium vivax glutathione reductase, putative 0.0046 0.0328 0.5043
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.3133 0.5239
Trichomonas vaginalis alpha-glucosidase, putative 0.0125 0.1196 0.5013
Schistosoma mansoni ran 0.0021 0.0054 0.0101
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.1819 0.305
Echinococcus granulosus geminin 0.0345 0.36 0.6035
Mycobacterium tuberculosis Probable reductase 0.0105 0.097 0.097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0329
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0328 0.2462
Echinococcus multilocularis protein dispatched 1 0.005 0.0378 0.0634
Echinococcus multilocularis lysosomal alpha glucosidase 0.0561 0.5965 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.065 0.065
Onchocerca volvulus 0.0059 0.0477 0.0603
Mycobacterium ulcerans alpha-mannosidase 0.0154 0.1512 1
Treponema pallidum NADH oxidase 0.0016 0 0.5
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0054 0.0834
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0039 0.0066
Echinococcus multilocularis lysosomal alpha mannosidase 0.0137 0.1331 0.2231
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0136 0.0228
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0106 0.0177
Schistosoma mansoni ran 0.0021 0.0054 0.0101
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0332 0.0557
Schistosoma mansoni alpha-glucosidase 0.0509 0.5391 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0328 0.2741
Trichomonas vaginalis alpha-glucosidase, putative 0.0125 0.1196 0.5013
Leishmania major GTP-binding protein, putative 0.0021 0.0054 0.0453
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.065 0.065
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Echinococcus multilocularis geminin 0.0345 0.36 0.6035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0621 0.1042
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0086 0.0764 0.3205
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0407
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Loa Loa (eye worm) hypothetical protein 0.0075 0.065 0.1065
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0103 0.0956 0.1602
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0332 0.0616
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0077 0.0325
Loa Loa (eye worm) hypothetical protein 0.0044 0.031 0.0494
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.065 0.4297
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.065 0.065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0299
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0561 0.5965 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 0.0956 0.1579
Loa Loa (eye worm) hypothetical protein 0.0103 0.0956 0.1579
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1098 1
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0108 0.101 0.7589
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2076 0.3463
Echinococcus granulosus importin subunit beta 1 0.0028 0.0136 0.0228
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0091
Echinococcus granulosus Protein patched homolog 1 0.0044 0.031 0.052
Echinococcus multilocularis snurportin 1 0.0302 0.3133 0.5252
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1098 0.1098
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0103 0.0956 0.1773
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Schistosoma mansoni cpg binding protein 0.0059 0.0477 0.0884
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0136 0.1022
Brugia malayi Muscleblind-like protein 0.0304 0.3152 0.5285
Loa Loa (eye worm) hypothetical protein 0.0054 0.0419 0.0677
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0018
Loa Loa (eye worm) MBCTL1 0.0053 0.0402 0.0648
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0125 0.1196 0.1148
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0328 0.5043
Brugia malayi beta-lactamase family protein 0.0075 0.065 0.1089
Loa Loa (eye worm) hypothetical protein 0.0053 0.0402 0.0648
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0057 0.0096
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0332 0.0557
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0077 0.0325
Echinococcus multilocularis muscleblind protein 0.0304 0.3152 0.5285
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.065 0.4882
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.1654
Loa Loa (eye worm) hypothetical protein 0.0073 0.0621 0.1017
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0136 0.1022
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0402 0.0674
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0077 0.0325
Loa Loa (eye worm) mannosidase 0.0103 0.0956 0.1579
Loa Loa (eye worm) hypothetical protein 0.0047 0.0345 0.0552
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0103 0.0956 0.4008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.065 0.065
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0103 0.0956 0.4008
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0161 0.1348
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0103 0.0956 0.4008
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0098 0.0895 0.166
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0062 0.0509 0.0944
Schistosoma mansoni hypothetical protein 0.0345 0.36 0.6678
Brugia malayi lysosomal alpha-mannosidase 0.0098 0.0895 0.15
Leishmania major glycosyl hydrolase-like protein 0.0073 0.0621 0.5197
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0402 0.0674
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.065 0.1089
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.5087 0.5087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0329
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0954 0.0904
Toxoplasma gondii ABC1 family protein 0.0075 0.065 0.5434
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.1095 0.9163
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0328 0.0523
Echinococcus granulosus lysosomal alpha glucosidase 0.0561 0.5965 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0341 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0212 0.0888
Trypanosoma brucei glucosidase, putative 0.0125 0.1196 0.8984
Echinococcus multilocularis muscleblind protein 1 0.0304 0.3152 0.5285
Brugia malayi Glycosyl hydrolases family 38 protein 0.0098 0.0895 0.15
Echinococcus multilocularis alpha mannosidase 2 0.0098 0.0895 0.15
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0621 0.2606
Echinococcus multilocularis expressed conserved protein 0.0097 0.0885 0.1484
Schistosoma mansoni hypothetical protein 0.0302 0.3133 0.5811
Brugia malayi Bromodomain containing protein 0.0038 0.0238 0.0399
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0137 0.1331 0.2468
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.1196 0.8984
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0506 0.0848
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.097 0.7151
Echinococcus granulosus snurportin 1 0.0302 0.3133 0.5252
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0341 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0341 0.0572
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0407
Brugia malayi mbt repeat family protein 0.0046 0.0332 0.0557
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.065 0.1205
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0073 0.0621 0.467
Leishmania major alpha glucosidase II subunit, putative 0.0125 0.1196 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0621 0.2606
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1438 0.241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0341 0.0633
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0048 0.0054
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0407
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0345 0.0578
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.117 0.194
Mycobacterium ulcerans lipase LipD 0.0075 0.065 0.4297
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0341 0.0572
Loa Loa (eye worm) beta-lactamase 0.0075 0.065 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.031 0.13
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0106 0.0177
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.097 0.097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0213 0.0357
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0402 0.0674
Trichomonas vaginalis alpha-glucosidase, putative 0.0125 0.1196 0.5013
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0332 0.0531
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0054 0.0453
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0103 0.0956 0.1602
Onchocerca volvulus 0.0075 0.065 0.0934
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.097 0.097
Schistosoma mansoni hypothetical protein 0.0043 0.0293 0.0543
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1098 0.1098
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.0023
Mycobacterium tuberculosis Possible conserved exported protein 0.093 1 1
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0154 0.1512 0.634
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0332 0.0327
Schistosoma mansoni importin beta-1 0.0028 0.0136 0.0252
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0621 0.2606
Echinococcus multilocularis zinc finger protein 0.0023 0.0074 0.0124
Brugia malayi Thioredoxin reductase 0.0046 0.0328 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0341 0.0633
Loa Loa (eye worm) hypothetical protein 0.0075 0.065 0.1065
Loa Loa (eye worm) glutathione reductase 0.0046 0.0328 0.0523
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0136 0.1137
Leishmania major importin beta-1 subunit, putative 0.0023 0.0077 0.0647
Brugia malayi Glycosyl hydrolases family 38 protein 0.0098 0.0895 0.15
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.065 0.1205
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.065 0.065
Echinococcus granulosus expressed conserved protein 0.0097 0.0885 0.1484
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.065 0.2724
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0621 0.2606
Loa Loa (eye worm) hypothetical protein 0.0038 0.0239 0.0374
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0213 0.0357
Schistosoma mansoni hypothetical protein 0.0345 0.36 0.6678
Loa Loa (eye worm) hypothetical protein 0.0102 0.0945 0.1562
Mycobacterium ulcerans beta-lactamase 0.0075 0.065 0.4297
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0402 0.0746
Schistosoma mansoni cpg binding protein 0.0065 0.0534 0.0991
Brugia malayi Pre-SET motif family protein 0.0031 0.0161 0.027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0106 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.065 0.2724
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.065 0.1089
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0137 0.1331 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.0328 1
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0103 0.0956 0.1602
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.031 0.052
Loa Loa (eye worm) hypothetical protein 0.0045 0.0322 0.0514
Brugia malayi Glycosyl hydrolases family 38 protein 0.0154 0.1512 0.2535
Loa Loa (eye worm) hypothetical protein 0.0075 0.065 0.1065
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.001 0.0016
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0328 0.0549
Brugia malayi Glycosyl hydrolases family 31 protein 0.0561 0.5965 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.065 0.1065
Echinococcus multilocularis lysosomal alpha glucosidase 0.0561 0.5965 1
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0103 0.0956 0.4008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0125 0.1196 0.5013
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0345 0.0578
Mycobacterium tuberculosis Conserved protein 0.0075 0.065 0.065
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.117 0.194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0341 0.0572
Plasmodium falciparum importin beta, putative 0.0028 0.0136 0.415
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.065 0.1065
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.065 0.4882
Trypanosoma brucei glycosyl hydrolase-like protein 0.0073 0.0621 0.467
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0621 0.2606
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0103 0.0956 0.1602
Brugia malayi MH2 domain containing protein 0.0123 0.117 0.1962
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0345 0.0639
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1438 0.241
Echinococcus granulosus lysosomal alpha mannosidase 0.0137 0.1331 0.2231
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.065 0.4882
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0073 0.0621 0.088
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0954 0.1599
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.065 0.065
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0092 0.0829 0.3476
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0103 0.0956 0.4008
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0054 0.0091
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0954 0.1599
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.097 0.097
Plasmodium vivax importin-beta 2, putative 0.0028 0.0136 0.2093
Brugia malayi beta-lactamase family protein 0.0075 0.065 0.1089
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0506 0.0848
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0332 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0345 0.0639
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0137 0.1331 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.097 0.097
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0154 0.1512 0.2514
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0332 0.0557
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.031 0.052
Echinococcus granulosus zinc finger protein 0.0023 0.0074 0.0124
Echinococcus granulosus muscleblind protein 0.0304 0.3152 0.5285
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 1
Brugia malayi Bromodomain containing protein 0.0077 0.067 0.1123
Echinococcus granulosus alpha mannosidase 2 0.0035 0.0212 0.0355
Echinococcus multilocularis protein patched 0.0044 0.031 0.052
Trichomonas vaginalis ran, putative 0.0021 0.0054 0.0227
Echinococcus granulosus neutral alpha glucosidase AB 0.0125 0.1196 0.2004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0135 0.0227
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0125 0.1196 1
Trichomonas vaginalis alpha-mannosidase, putative 0.0154 0.1512 0.634
Loa Loa (eye worm) hypothetical protein 0.0103 0.0954 0.1576
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.065 0.2724
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0064
Trichomonas vaginalis maltase-glucoamylase, putative 0.0125 0.1196 0.5013
Brugia malayi mbt repeat family protein 0.0046 0.0332 0.0557
Brugia malayi PHD-finger family protein 0.0028 0.0131 0.022
Brugia malayi beta-lactamase 0.0075 0.065 0.1089
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0103 0.0956 0.4008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0621 0.057
Echinococcus granulosus cpg binding protein 0.0065 0.0534 0.0895
Schistosoma mansoni alpha glucosidase 0.0125 0.1196 0.2218
Onchocerca volvulus 0.0098 0.0895 0.1403
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0332 0.0616
Brugia malayi Importin beta-1 subunit 0.0028 0.0136 0.0228
Schistosoma mansoni hypothetical protein 0.0043 0.0293 0.0543
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0332 0.0616
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0028 0.0136 0.0201
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0103 0.0956 0.1602
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.065 0.1089
Mycobacterium tuberculosis Conserved protein 0.0075 0.065 0.065
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0621 0.2606
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0402 0.0674
Echinococcus multilocularis transfer RNA-Trp 0.0103 0.0956 0.1602
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0621 0.2606
Leishmania major trypanothione reductase 0.0046 0.0328 0.2741
Schistosoma mansoni hypothetical protein 0.0043 0.0293 0.0543
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.065 0.2724
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0054 0.0091
Onchocerca volvulus 0.0075 0.065 0.0934
Leishmania major hypothetical protein, conserved 0.0075 0.065 0.5434
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.065 0.4297
Loa Loa (eye worm) hypothetical protein 0.004 0.0264 0.0417
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0137 0.1331 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0073 0.0621 0.467
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0328 0.0549
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.031 0.0494
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0971 0.1802
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0402 0.0674
Loa Loa (eye worm) hypothetical protein 0.0075 0.065 0.1065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1217 0.2258
Schistosoma mansoni zinc finger protein 0.0023 0.0074 0.0137
Loa Loa (eye worm) hypothetical protein 0.0089 0.08 0.1318
Mycobacterium ulcerans hypothetical protein 0.0075 0.065 0.4297
Echinococcus granulosus alpha mannosidase 2 0.0029 0.0147 0.0247
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.065 0.065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Onchocerca volvulus 0.0234 0.2385 0.4252
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0161 0.027
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0959
Brugia malayi RNA, U transporter 1 0.008 0.0707 0.1185
Loa Loa (eye worm) hypothetical protein 0.0304 0.3152 0.5272
Loa Loa (eye worm) hypothetical protein 0.0098 0.0895 0.1476
Trichomonas vaginalis sucrase-isomaltase, putative 0.0125 0.1196 0.5013
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.1196 0.8984
Onchocerca volvulus 0.0098 0.0895 0.1403
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.065 0.065
Trypanosoma brucei trypanothione reductase 0.0046 0.0328 0.2462
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0341 0.0546
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0125 0.1196 0.1148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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