Detailed information for compound 582365

Basic information

Technical information
  • TDR Targets ID: 582365
  • Name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(3-methy lbut-2-enylamino)purin-9-yl]tetrahydrofuran-3 ,4-diol
  • MW: 335.358 | Formula: C15H21N5O4
  • H donors: 4 H acceptors: 6 LogP: 0.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCC=C(C)C
  • InChi: 1S/C15H21N5O4/c1-8(2)3-4-16-13-10-14(18-6-17-13)20(7-19-10)15-12(23)11(22)9(5-21)24-15/h3,6-7,9,11-12,15,21-23H,4-5H2,1-2H3,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
  • InChiKey: USVMJSALORZVDV-SDBHATRESA-N  


Substructure search Similarity search

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Synonyms

  • (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(3-methylbut-2-enylamino)-9-purinyl]tetrahydrofuran-3,4-diol
  • (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(3-methylbut-2-enylamino)purin-9-yl]oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-[6-(3-methylbut-2-enylamino)purin-9-yl]-5-methylol-tetrahydrofuran-3,4-diol
  • Isopentenyladenosine
  • 7724-76-7
  • 33156-15-9
  • SQ 22558
  • ZK 20 242
  • D05726
  • Riboprine (USAN)
  • ZINC00057125
  • C16427
  • Isopentenyl adenosine
  • 2-IPA
  • 2iPA
  • 6-(3-Methyl-2-butenylamino)purine riboside
  • 6-(gamma,gamma-Dimethylallylamino)purine riboside
  • 6-N-((3-Methyl-2-butenyl)amino)-9-beta-D-ribofuranosyl-9H-purine
  • 6-N-((3-Methyl-2-butenyl)amino)-9beta-D-ribofuranosylpurine
  • 9beta-D-Ribofuranosyl-9H-purine, N-(3-methyl-2-butenylamino)-
  • ADENOSINE, N-(3-METHYL-2-BUTENYL)-
  • Dimethylallyladenosine
  • EINECS 231-771-3
  • Isopentenyl adenine riboside
  • Isopentenyladenosine riboside
  • N(sup 6)-(2-Isopentenyl)adenosine
  • N(sup 6)-(delta(sup 2)-Isopentenyl)adenosine
  • N(sup 6)-Dimethylallyladenosine
  • N(sup 6)-Isopentenyladenosine
  • N-(3-Methyl-2-butenyl)adenosine
  • N-Isopentenyladenosine
  • N6-(2-Isopentenyl)adenosine
  • N6-(3-Methyl-2-butenyl)adenosine
  • N6-Isopentenyladenosine
  • NSC 105546
  • Riboprina [INN-Spanish]
  • Riboprine
  • Riboprine [USAN:INN]
  • Riboprinum [INN-Latin]

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Curated by TDR Targets References
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase glyceraldehyde 3-phosphate dehydrogenase, glycosomal 361 aa 371 aa 39.6 %
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase glyceraldehyde 3-phosphate dehydrogenase, glycosomal 361 aa 371 aa 39.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0757
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0236 0.0802 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 0.0782
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0022 0.0412
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0013 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0164 0.0537 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0019 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0457 0.85
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0172 0.0172
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.0463 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0236 0.0802 0.9849
Onchocerca volvulus 0.0142 0.0457 0.0665
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0007 0.0007
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0042 0.0091 0.0486
Onchocerca volvulus 0.0061 0.0163 0.0237
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0042 0.0091 0.0091
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0007 0.0011
Echinococcus granulosus chromobox protein 2 0.0023 0.0022 0.0022
Echinococcus granulosus peptidase Clp S14 family 0.0155 0.0505 0.0505
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0091 0.0486
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0046 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0046 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 0.0782
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Echinococcus multilocularis somatostatin receptor 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0057 0.0145 0.1742
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Brugia malayi Dopamine receptor 0.0022 0.0019 0.0031
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0091 0.0486
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0019 0.0019
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0007 0.0012
Brugia malayi sulfakinin receptor protein 0.0022 0.0019 0.0031
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0066 0.011
Brugia malayi CHD4 protein 0.0026 0.0035 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0115 0.0191
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0022 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0046 0.0067
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0019 0.0019
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0026 0.0026
Trichomonas vaginalis hypothetical protein 0.0023 0.0022 0.0032
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0057 0.0145 0.0768
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0022 0.0032
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0236 0.2901
Echinococcus multilocularis zinc finger protein 0.0024 0.0028 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0161 0.1979
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.0192 0.0319
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.054
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0106 0.0326 0.5887
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.054
Schistosoma mansoni amine GPCR 0.0022 0.0019 0.0019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0022 0.0412
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0035 0.0035
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0236 0.0802 0.0802
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0096 0.0288 0.0419
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0042 0.0091 0.0336
Brugia malayi PAS domain containing protein 0.0047 0.0111 0.0184
Onchocerca volvulus Alhambra homolog 0.0029 0.0043 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0457 0.85
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0042 0.0091 0.0132
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0019 0.0019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0224 0.0326
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0161 0.1291
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0035 0.0035
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.018 0.3352
Onchocerca volvulus 0.0042 0.0091 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0091 0.0151
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0019 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0078 0.0078
Schistosoma mansoni adenoreceptor 0.0022 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0091 0.0151
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0044 0.0073
Schistosoma mansoni hypothetical protein 0.0029 0.0043 0.0043
Echinococcus granulosus orexin receptor type 2 0.0022 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0022 0.0019 0.0019
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0046 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Brugia malayi hypothetical protein 0.0143 0.0463 0.0767
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0026 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0019 0.0019
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.0091 0.1691
Onchocerca volvulus 0.0029 0.0044 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0007 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0142 0.0457 0.5307
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0003 0.0003
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0211 0.0211
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0236 0.0802 0.133
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Entamoeba histolytica hypothetical protein 0.0019 0.0007 0.0139
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0007 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0102 0.0313 0.0313
Brugia malayi neuropeptide F receptor 0.0022 0.0019 0.0031
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0091 0.1691
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0022 0.0022
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0107 0.0331 0.537
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0019 0.0031
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0042 0.0091 0.0486
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0448 0.0652
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0084 0.0084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus expressed protein 0.0366 0.1276 0.1276
Brugia malayi hypothetical protein 0.0019 0.0007 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0022 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0043 0.0531
Schistosoma mansoni amine GPCR 0.0022 0.0019 0.0019
Brugia malayi AKH receptor 0.0022 0.0019 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Brugia malayi SET domain containing protein 0.0032 0.0057 0.0094
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0042 0.0091 0.1133
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0082 0.1017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Leishmania major cathepsin L-like protease 0.0064 0.0172 0.3201
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0019 0.0019
Schistosoma mansoni myosin xvIII 0.0022 0.0019 0.0019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0007 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0103 0.1266
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0107 0.0331 0.6153
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.024 0.0814 0.0814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0056 0.0145 0.0211
Entamoeba histolytica hypothetical protein 0.0019 0.0007 0.0139
Brugia malayi G-protein coupled receptor 0.0022 0.0019 0.0031
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0007 0.0007
Brugia malayi Heterochromatin protein 1 0.0139 0.0448 0.0743
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.018 0.3352
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0022 0.0272
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0019 0.0019
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0757
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0019 0.0019
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0019 0.0031
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.003 0.0047 0.0078
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0042 0.0091 0.0336
Echinococcus granulosus allatostatin A receptor 0.0022 0.0019 0.0019
Toxoplasma gondii propionate-CoA ligase 0.0042 0.0091 0.1116
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0051 0.0124 0.2312
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0281 0.0281
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0107 0.0331 0.5816
Echinococcus granulosus sex peptide receptor 0.0022 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0091 0.0336
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0019
Brugia malayi neuropeptide F receptor 0.0022 0.0019 0.0031
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0007 0.0007
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0236 0.0802 0.0802
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0007 0.0012
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0042 0.0091 0.1116
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0164 0.0537 0.0537
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0019 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0013 0.0013
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0019 0.0027
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0107 0.0331 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0141 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0013 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0013 0.0013
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0106 0.0176
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0154 0.0256
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0022
Echinococcus granulosus chromobox protein 1 0.0139 0.0448 0.0448
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0164 0.0537 0.0537
Loa Loa (eye worm) helicase 0.0023 0.0022 0.0037
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0107 0.0331 0.6153
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0007 0.0007
Schistosoma mansoni single-minded 0.0047 0.0111 0.0111
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0042 0.0091 0.0336
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Schistosoma mansoni chromobox protein 0.0023 0.0022 0.0022
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0043 0.0043
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0019 0.0019
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0022 0.0272
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0115 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0106 0.0106
Schistosoma mansoni neuropeptide receptor 0.0022 0.0019 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0078 0.0078
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0164 0.0537 0.6699
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0011
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0107 0.0331 0.0549
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Onchocerca volvulus 0.0022 0.0019 0.0027
Onchocerca volvulus 0.0042 0.0091 0.0132
Brugia malayi hypothetical protein 0.0019 0.0007 0.0012
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0236 0.2945
Schistosoma mansoni bromodomain containing protein 0.0067 0.0184 0.0184
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0019 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Mycobacterium ulcerans acetyl-CoA synthetase 0.0042 0.0091 0.0336
Brugia malayi Bromodomain containing protein 0.0041 0.0089 0.0148
Echinococcus granulosus tumor protein p63 0.0681 0.2425 0.2425
Schistosoma mansoni amine GPCR 0.0022 0.0019 0.0019
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0043 0.0043
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0013 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0019 0.0019
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0305 0.5401
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0042 0.0091 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0019 0.0031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0142 0.0457 0.5307
Schistosoma mansoni amine GPCR 0.0022 0.0019 0.0019
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0164 0.0537 1
Brugia malayi Bromodomain containing protein 0.0079 0.0226 0.0376
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0013 0.0013
Echinococcus granulosus peregrin 0.0034 0.0065 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0019 0.0019
Schistosoma mansoni chromobox protein 0.0139 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0091 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Entamoeba histolytica hypothetical protein 0.0143 0.0463 0.861
Echinococcus granulosus g protein coupled receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis chromobox protein 1 0.0139 0.0448 0.0448
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0007 0.0007
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0164 0.0537 0.0537
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.054
Brugia malayi hypothetical protein 0.0023 0.0022 0.0037
Echinococcus granulosus g protein coupled receptor 0.0022 0.0019 0.0019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0019 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus granulosus zinc finger protein 0.0024 0.0028 0.0028
Brugia malayi hypoxia-induced factor 1 0.0146 0.0471 0.0782
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0019 0.0019
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0022 0.0276
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0007 0.0012
Schistosoma mansoni chromobox protein 0.0023 0.0022 0.0022
Brugia malayi Serotonin receptor 0.0022 0.0019 0.0031
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0013 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0172 0.3201
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0082 0.1519
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0477 0.0477
Brugia malayi putative neuropeptide receptor 0.0022 0.0019 0.0031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0044 0.0073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0103 0.015
Schistosoma mansoni peptidase Clp (S14 family) 0.0236 0.0802 0.0802
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 0.0782
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0106 0.0106
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0042 0.0091 0.0336
Leishmania major cathepsin L-like protease 0.0064 0.0172 0.3201
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.018 0.0299
Onchocerca volvulus 0.1898 0.687 1
Brugia malayi Probable ClpP-like protease 0.0236 0.0802 0.133
Brugia malayi larval opioid receptor 0.0022 0.0019 0.0031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0106 0.0176
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0019 0.0019
Brugia malayi PXA domain containing protein 0.0019 0.0007 0.0012
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0164 0.0537 1
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0022 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0107 0.0331 0.0549
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Brugia malayi GnHR receptor homolog 0.0022 0.0019 0.0031
Brugia malayi ORL1-like opioid receptor 0.0022 0.0019 0.0031
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0164 0.0537 0.6598
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0042 0.0091 0.0336
Schistosoma mansoni zinc finger protein 0.0024 0.0028 0.0028
Onchocerca volvulus 0.0263 0.0898 0.1307
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0007 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0047 0.0047
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0022 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Entamoeba histolytica hypothetical protein 0.0143 0.0463 0.861
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.018 0.018
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0022 0.0272
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0043 0.0531
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.0091 0.1691
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0007 0.0007
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0022 0.0032
Echinococcus granulosus chromobox protein 1 0.0139 0.0448 0.0448
Onchocerca volvulus 0.0022 0.0019 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0142 0.0457 0.8897
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0078 0.0224 0.0372
Echinococcus multilocularis sex peptide receptor 0.0022 0.0019 0.0019
Plasmodium vivax acyl-CoA synthetase, putative 0.0106 0.0326 0.4
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0172 0.0172
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0164 0.0537 1
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Brugia malayi PHD-finger family protein 0.0029 0.0043 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) heterochromatin protein 1 0.0139 0.0448 0.0743
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0196
Brugia malayi G protein-coupled receptor 0.0022 0.0019 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.0463 0.0463
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0013 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.018 0.3352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0051 0.0124 0.2312
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0022 0.0276
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0019 0.0031
Schistosoma mansoni chromobox protein 0.0139 0.0448 0.0448
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0163 0.027
Entamoeba histolytica hypothetical protein 0.0023 0.0022 0.0412
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.0091 0.0132
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0019 0.0031
Entamoeba histolytica acyl-coA synthetase, putative 0.0142 0.0457 0.85
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0162
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0007 0.0007
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0224 0.0326
Echinococcus granulosus neuropeptide receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0047 0.0111 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0011
Schistosoma mansoni neuropeptide receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0152 0.0495 0.0821
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Onchocerca volvulus 0.0022 0.0019 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0091 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0007 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.023 0.078 0.078
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0019 0.0031
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0091 0.0486
Echinococcus multilocularis chromobox protein 1 0.0139 0.0448 0.0448
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0305 0.5401
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0007 0.0007
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0019 0.0031
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0022 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0161 0.0161
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0022 0.0272
Echinococcus granulosus Chromobox protein 3 0.0023 0.0022 0.0022
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0019 0.0031
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0043 0.0531
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0013 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0161 0.1291
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0113 0.0352 0.0584
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0164 0.0537 0.4441
Entamoeba histolytica hypothetical protein 0.0023 0.0022 0.0412
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0081 0.0236 0.2044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Loa Loa (eye worm) hypothetical protein 0.01 0.0303 0.0502
Entamoeba histolytica hypothetical protein 0.0019 0.0007 0.0139
Onchocerca volvulus 0.0023 0.0022 0.0032
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0066 0.0066
Plasmodium vivax SET domain protein, putative 0.024 0.0814 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0471 0.0782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0091 0.1691
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0161 0.1291
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0152 0.2824
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0019 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0013 0.0021
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Onchocerca volvulus 0.0022 0.0019 0.0027
Schistosoma mansoni hypothetical protein 0.0143 0.0463 0.0463
Onchocerca volvulus 0.01 0.0303 0.0441
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0192 0.2353
Brugia malayi Protein cec-1. 0.0023 0.0022 0.0037
Onchocerca volvulus 0.0022 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0046 0.0067
Brugia malayi PHD-finger family protein 0.003 0.0047 0.0078
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0022 0.0019 0.0019
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0042 0.0091 0.0151
Echinococcus multilocularis serotonin receptor 0.0022 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0081 0.0236 0.2901
Brugia malayi jmjC domain containing protein 0.0094 0.0281 0.0466
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0043 0.0072
Echinococcus multilocularis peregrin 0.0034 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0033 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0007 0.0007
Onchocerca volvulus 0.0022 0.0019 0.0027
Brugia malayi Pre-SET motif family protein 0.024 0.0814 0.1351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0106 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0263 0.0898 0.0898
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0042 0.0091 0.0486
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0013 0.0013
Echinococcus granulosus jumonji domain containing protein 0.004 0.0084 0.0084
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0007 0.0007
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0042 0.0091 0.0336
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0164 0.0537 1
Brugia malayi MH2 domain containing protein 0.0238 0.0807 0.1338
Echinococcus multilocularis peptidase Clp (S14 family) 0.0155 0.0505 0.0505
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0019 0.0019
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0164 0.0537 0.6598
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0155 0.0505 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Brugia malayi chromobox protein homolog 3 0.0078 0.0224 0.0372
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0068 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0457 0.0757
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0091 0.1691
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0051 0.0124 0.2312
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0457 0.8897
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0305 0.5401
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0022 0.0037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0155 0.0505 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0107 0.0331 0.0331
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0089 0.0263 0.0437
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.0091 0.1691
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0246 0.0358
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0019 0.0031
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0161 0.3
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni opsin-like receptor 0.0022 0.0019 0.0019
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0091 0.1116
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0013 0.0013
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0019 0.0019
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0007 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0142 0.0457 0.5307
Echinococcus granulosus g protein coupled receptor 0.0022 0.0019 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0457 0.85
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0019 0.0031
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0158 0.0516 0.0856
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0115 0.0191
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0457 0.0757
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0046 0.0067
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Echinococcus granulosus serotonin receptor 0.0022 0.0019 0.0019
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0022 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0059 0.0098
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0051 0.0124 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1667 0.6029 1
Brugia malayi hypothetical protein 0.0158 0.0516 0.0856
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0022 0.0022
Echinococcus granulosus fmrfamide receptor 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0022 0.0022
Onchocerca volvulus 0.0022 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0007 0.0007
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0256 0.0875 0.0875
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0113 0.0352 0.0584
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0019 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0102 0.0313 0.0313
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0022 0.0032
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0164 0.0537 0.0537
Schistosoma mansoni voltage-gated potassium channel 0.0112 0.0347 0.0347
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0011
Brugia malayi Melatonin receptor type 1A 0.0022 0.0019 0.0031
Plasmodium vivax acetyl-CoA synthetase, putative 0.0042 0.0091 0.1116
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0072
Onchocerca volvulus 0.0035 0.0066 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0007 0.0007
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0102 0.0313 0.0518
Echinococcus granulosus voltage gated potassium channel 0.003 0.0047 0.0047
Onchocerca volvulus 0.0022 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0457 0.5144
Schistosoma mansoni neuropeptide receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Echinococcus multilocularis chromobox protein 2 0.0023 0.0022 0.0022
Trichomonas vaginalis set domain proteins, putative 0.1898 0.687 1
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0172 0.3201
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0007 0.0012
Brugia malayi Pre-SET motif family protein 0.1667 0.6029 1
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0051
Schistosoma mansoni opsin-like receptor 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0019 0.0019
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0236 0.0802 0.9849
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0019 0.0031
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0026 0.0026
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0013 0.0013
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0078 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0091 0.0151
Mycobacterium ulcerans hypothetical protein 0.0142 0.0457 0.5307
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0164 0.0537 1
Entamoeba histolytica hypothetical protein 0.0143 0.0463 0.861
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0042 0.0091 0.0486
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0164 0.0537 0.5321
Brugia malayi jmjC domain containing protein 0.0038 0.0078 0.0129
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0047 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.0807 0.1338
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0305 0.5401
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0103 0.0103
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.024 0.0814 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0457 0.0757
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0164 0.0537 0.6598
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0022 0.0032
Loa Loa (eye worm) oxidoreductase 0.0042 0.0091 0.0151
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0078 0.0129
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0013 0.0013
Echinococcus granulosus hypothetical protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0151
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Brugia malayi PXA domain containing protein 0.0019 0.0007 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus somatostatin receptor 0.0022 0.0019 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0256 0.0875 0.0875
Schistosoma mansoni biogenic amine receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.018 0.1999
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0013 0.0013
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0019 0.0027
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0103 0.015
Echinococcus granulosus single minded 2 0.0044 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0164 0.0537 0.6402
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0007 0.0007
Brugia malayi Serotonin receptor 0.0022 0.0019 0.0031
Brugia malayi CXXC zinc finger family protein 0.0029 0.0044 0.0073
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0019 0.0019
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0107 0.0331 0.6153
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0019 0.0019
Brugia malayi Bromodomain containing protein 0.0034 0.0065 0.0107
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0013 0.0013
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0164 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0122 0.2272
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0022 0.0272
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0019 0.0031
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0013 0.0013
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0011
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0107 0.0331 0.0549
Leishmania major cathepsin L-like protease 0.0064 0.0172 0.3201
Brugia malayi Dopamine receptor protein 2 0.0022 0.0019 0.0031
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0019 0.0019
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.0091 0.0132
Entamoeba histolytica hypothetical protein 0.0023 0.0022 0.0412
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0194 0.0194
Echinococcus granulosus cpg binding protein 0.0032 0.0057 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0326 0.3528
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.018 0.0299
Onchocerca volvulus 0.0152 0.0495 0.072
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0035 0.0058
Echinococcus multilocularis Chromo domain 0.0023 0.0022 0.0022
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0051 0.0124 0.2312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0106 0.0106
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0022 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0033 0.0048
Brugia malayi RE15519p 0.0022 0.0019 0.0031
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0164 0.0537 0.0537
Echinococcus multilocularis microtubule associated protein 2 0.2754 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0065 0.0065
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 0.0782
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0019 0.0019
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0035 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0091 0.0486
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Leishmania major protein kinase, putative 0.0026 0.0033 0.0612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Loa Loa (eye worm) hypothetical protein 0.0256 0.0875 0.1452
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0082 0.0776
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0172 0.3201
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0281 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.024 0.0814 0.0814
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0457 0.5307
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Echinococcus granulosus Chromo domain 0.0023 0.0022 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0115 0.0191
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0022 0.0272
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.0256 0.0875 0.0875
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0051 0.0124 0.2312
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0164 0.0537 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0142 0.0457 0.5307
Entamoeba histolytica hypothetical protein 0.0143 0.0463 0.861
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0019 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0019 0.0031
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0042 0.0091 0.0486
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0068 0.0068
Schistosoma mansoni acetyl-CoA synthetase 0.0042 0.0091 0.0091
Echinococcus multilocularis serotonin receptor 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0019 0.0019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0019 0.0019
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0019 0.0031
Schistosoma mansoni opsin-like receptor 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0022 0.0019 0.0027
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0019 0.0019
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.018 0.018
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.0091 0.1691
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0172 0.3201
Onchocerca volvulus 0.0022 0.0019 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0019 0.0031
Schistosoma mansoni cpg binding protein 0.0032 0.0057 0.0057
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0047 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0042 0.0091 0.0091
Schistosoma mansoni histamine h1 receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0127
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0047 0.0047
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0103 0.1266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0106 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0457 0.85
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0477 0.0791
Brugia malayi hypothetical protein 0.0152 0.0495 0.0821
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0007 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0457 0.5307
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0022 0.0032
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0022 0.0412
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0019 0.0019
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0164 0.0537 1
Onchocerca volvulus 0.0042 0.0091 0.0132
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0035 0.0051
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0078
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0059 0.0098
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0019 0.0019
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0007 0.0007
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0046 0.0067
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0164 0.0537 0.0537
Plasmodium falciparum phd finger protein, putative 0.0029 0.0043 0.0539
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0019 0.0019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0246 0.0358
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0164 0.0537 0.0537
Onchocerca volvulus 0.0023 0.0022 0.0032
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0013 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.2754 1 1
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0046 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0019 0.0019
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0078 0.0078
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0164 0.0537 0.0782
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.0807 0.1338
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0022 0.0276
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0141 0.0205
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0457 0.0757
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0103 0.1266
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0091 0.0151
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Schistosoma mansoni cpg binding protein 0.0032 0.0057 0.0057
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0107 0.0331 0.0331
Echinococcus multilocularis cpg binding protein 0.0032 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Brugia malayi hypothetical protein 0.0022 0.0019 0.0031
Echinococcus granulosus neuropeptide receptor 0.0022 0.0019 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0454 0.0454
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0224 0.0326
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0019 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0161 0.0161
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0111 0.0111
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0013 0.0021
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0007 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Echinococcus multilocularis tumor protein p63 0.0681 0.2425 0.2425
Brugia malayi Dopamine receptor protein 1 0.0022 0.0019 0.0031
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0091 0.0336
Schistosoma mansoni biogenic amine receptor 0.0022 0.0019 0.0019
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Schistosoma mansoni biogenic amine receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0078 0.0078
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0161 0.2103
Plasmodium falciparum acyl-CoA synthetase 0.0106 0.0326 0.4061
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0019 0.0031
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0096 0.0288 0.0419
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0457 0.5307
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0164 0.0537 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0007 0.0012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.018 0.3352
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0019 0.0019
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0056 0.0145 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0013 0.0019
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0164 0.0537 0.0891
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0107 0.0331 0.0482
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0091 0.0151
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0155 0.0505 0.5818
Echinococcus multilocularis expressed protein 0.0366 0.1276 0.1276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0256 0.0875 0.0875
Loa Loa (eye worm) acetyltransferase 0.0147 0.0477 0.0791
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0022 0.0032
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0102 0.0313 0.0518
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0019 0.0019
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0164 0.0537 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0007 0.0012
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0042 0.0091 0.0336
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0246 0.0358
Brugia malayi G-protein coupled receptor 0.0022 0.0019 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0161 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0172 0.1817
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0042 0.0091 0.0486
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0236 0.0802 0.9849
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0019 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0457 0.5144
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0091 0.1691
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0047 0.0047
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0448 0.0652
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0236 0.0802 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0457 0.85

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) at protein/ligand 1:10 to 1:100 molar ratio by 2D COSY NMR analysis ChEMBL. 25184810
Activity (binding) Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) at protein/ligand 1:10 to 1:100 molar ratio by WaterLOGSY NMR analysis ChEMBL. 25184810
Activity (binding) Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) at protein/ligand 1:10 to 1:100 molar ratio by saturation transfer difference NMR analysis ChEMBL. 25184810
Activity (binding) Inhibition of human brain MAOA ChEMBL. 18834112
Activity (binding) Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) at protein/ligand 1:10 to 1:100 molar ratio by WaterLOGSY 1D 1H NMR analysis ChEMBL. 25184810
CC50 (ADMET) = 5.8 uM Cytotoxicity against human RD cells ChEMBL. 26854380
IC50 (binding) > 5000 uM Inhibitory activity measured for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Leishmania. mexicana ChEMBL. 9822549
Inhibition (binding) = 84 % Inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase) ChEMBL. 9934461
Inhibition (binding) = 84 % Inhibitory activity was measured for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Leishmania. mexicana at 10 mM ChEMBL. 9822549
Kd (binding) = 0.55 mM Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H11 of isopentenylic moiety by saturation transfer difference NMR analysis ChEMBL. 25184810
Kd (binding) = 1.21 mM Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H14-H15 of isopentenylic moiety by saturation transfer difference NMR analysis ChEMBL. 25184810
Kd (binding) = 2.02 mM Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H2/H8 of purine ring by saturation transfer difference NMR analysis ChEMBL. 25184810
Kd (binding) = 2.21 mM Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H12 of isopentenylic moiety by saturation transfer difference NMR analysis ChEMBL. 25184810
Potency (functional) 3.3489 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8325 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from in-silico analysis (ECO:0000043) Leishmania mexicana 28592  
Annotator: aaronjr@u.washington.edu Comment: Drug: 4546-55-8; Drug: 158555-06-7; Drug: 13389-15-6; Drug: 15262-12-1; Drug: 65456-83-9; Drug: 65456-85-1; Drug: 65456-86-2; Drug: 102029-71-0; Drug: 220522-93-0; Drug: 220522-94-1; Drug: 220522-95-2; Drug: 220522-96-3; Drug: 220522-97-4; Drug: 220522-98-5; Drug: 220522-99-6; Drug: 220523-00-2; Drug: 220523-01-3; Drug: 220523-02-4; Drug: 220523-03-5; Drug: 220523-04-6; Drug: 220523-05-7; Drug: 220523-06-8; Drug: 220523-07-9. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; References: 9934461
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from in-silico analysis (ECO:0000043) Leishmania mexicana 26942  
Annotator: aaronjr@u.washington.edu Comment: Drug: 4546-55-8; Drug: 158555-06-7; Drug: 13389-15-6; Drug: 15262-12-1; Drug: 65456-83-9; Drug: 65456-85-1; Drug: 65456-86-2; Drug: 102029-71-0; Drug: 220522-93-0; Drug: 220522-94-1; Drug: 220522-95-2; Drug: 220522-96-3; Drug: 220522-97-4; Drug: 220522-98-5; Drug: 220522-99-6; Drug: 220523-00-2; Drug: 220523-01-3; Drug: 220523-02-4; Drug: 220523-03-5; Drug: 220523-04-6; Drug: 220523-05-7; Drug: 220523-06-8; Drug: 220523-07-9. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; References: 9934461
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania mexicana 28592  
Annotator: aaronjr@u.washington.edu Comment: Drug: 4546-55-8; Drug: 158555-06-7; Drug: 13389-15-6; Drug: 15262-12-1; Drug: 65456-83-9; Drug: 65456-85-1; Drug: 65456-86-2; Drug: 102029-71-0; Drug: 220522-93-0; Drug: 220522-94-1; Drug: 220522-95-2; Drug: 220522-96-3; Drug: 220522-97-4; Drug: 220522-98-5; Drug: 220522-99-6; Drug: 220523-00-2; Drug: 220523-01-3; Drug: 220523-02-4; Drug: 220523-03-5; Drug: 220523-04-6; Drug: 220523-05-7; Drug: 220523-06-8; Drug: 220523-07-9. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; References: 9934461
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania mexicana 26942  
Annotator: aaronjr@u.washington.edu Comment: Drug: 4546-55-8; Drug: 158555-06-7; Drug: 13389-15-6; Drug: 15262-12-1; Drug: 65456-83-9; Drug: 65456-85-1; Drug: 65456-86-2; Drug: 102029-71-0; Drug: 220522-93-0; Drug: 220522-94-1; Drug: 220522-95-2; Drug: 220522-96-3; Drug: 220522-97-4; Drug: 220522-98-5; Drug: 220522-99-6; Drug: 220523-00-2; Drug: 220523-01-3; Drug: 220523-02-4; Drug: 220523-03-5; Drug: 220523-04-6; Drug: 220523-05-7; Drug: 220523-06-8; Drug: 220523-07-9. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; References: 9934461

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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