Detailed information for compound 585566

Basic information

Technical information
  • TDR Targets ID: 585566
  • Name: (2S)-2-[[(2S)-2-[2-[[2-[[(2S)-2-(diallylamino )-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]a mino]ethylsulfanyl]-3-phenyl-propanoyl]amino] -4-methyl-pentanoic acid
  • MW: 638.817 | Formula: C34H46N4O6S
  • H donors: 5 H acceptors: 6 LogP: 2.9 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCN([C@H](C(=O)NCC(=O)NCCS[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccccc1)Cc1ccc(cc1)O)CC=C
  • InChi: 1S/C34H46N4O6S/c1-5-17-38(18-6-2)29(21-26-12-14-27(39)15-13-26)32(41)36-23-31(40)35-16-19-45-30(22-25-10-8-7-9-11-25)33(42)37-28(34(43)44)20-24(3)4/h5-15,24,28-30,39H,1-2,16-23H2,3-4H3,(H,35,40)(H,36,41)(H,37,42)(H,43,44)/t28-,29-,30-/m0/s1
  • InChiKey: CZRZYRKTYLLLRL-DTXPUJKBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2S)-2-[2-[[2-[[(2S)-2-(diallylamino)-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxoethyl]amino]ethylthio]-1-oxo-3-phenylpropyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S)-2-[2-[2-[[(2S)-2-[bis(prop-2-enyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]ethanoylamino]ethylsulfanyl]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S)-2-[2-[[2-[[(2S)-2-(diallylamino)-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]ethylthio]-3-phenyl-propanoyl]amino]-4-methyl-valeric acid
  • (2S)-2-[[(2S)-2-[2-[[2-[[(2S)-2-[bis(prop-2-enyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]ethylsulfanyl]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
  • ICI 154129
  • (2S)-2-[[(2S)-2-[2-[[2-[[(2S)-2-(di(prop-2-enyl)amino)-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]ethylsulfanyl]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S)-2-[2-[2-[[(2S)-2-(di(prop-2-enyl)amino)-3-(4-hydroxyphenyl)propanoyl]amino]ethanoylamino]ethylsulfanyl]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid
  • 83420-94-4
  • M-154,129
  • N,N-Bis(allyl)-tyr-gly-gly-psi-methylthio-phe-leu
  • N,N-Bis(allyl)-tyrosyl-glycyl-glycyl-psi-methylthio-phenylalanyl-leucine
  • N,N-Di-2-propenyl-L-tyrosylglycyl-(alphaS)-alpha-((2-aminoethyl)thio)benzenepropanoyl-L-leucine
  • Glycinamide, N,N-di-2-propenyl-L-tyrosyl-N-(2-((2-((1-carboxy-3-methylbutyl)amino)-2-oxo-1-(phenylmethyl)ethyl)thio)ethyl)-, (S-(R*,R*))-
  • ICI-154129
  • L-Leucine, N,N-di-2-propenyl-L-tyrosylglycyl-(alphaS)-alpha-((2-aminoethyl)thio)benzenepropanoyl-
  • M 154,129

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0048 0.0546 0.0546
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0032 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0032 0.0314 0.0634
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.2601 0.2601
Echinococcus granulosus peregrin 0.0031 0.0296 0.0296
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0261 0.3659
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.015 0.015
Onchocerca volvulus 0.0032 0.0314 0.0515
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.015 0.015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.02 0.2806 0.2806
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0303 0.4351 0.8779
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0534 0.0534
Echinococcus granulosus dna polymerase eta 0.0019 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.015 0.0304
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0351 0.0351
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0684 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0314 0.0634
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0081 0.0319
Schistosoma mansoni bromodomain containing protein 0.0064 0.0788 0.0788
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0804 1
Echinococcus multilocularis neuropeptide receptor A26 0.049 0.7128 0.7128
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0344 0.4956 0.4956
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0117 0.0237
Schistosoma mansoni hypothetical protein 0.007 0.0874 0.0874
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0117 0.0237
Brugia malayi jmjC domain containing protein 0.0038 0.0404 0.0815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1231 0.1231
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.2601 0.2601
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0534 0.0534
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1231 0.2484
Echinococcus multilocularis ectonucleotide 0.0027 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0481
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0261 0.9023
Brugia malayi Cell death protein 3 precursor 0.0031 0.0287 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.015 0.0304
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0399 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.015 0.0304
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0735 0.0735
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.038 0.1633
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.4161 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.1376 0.2777
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0136 0.0274
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0287 0.0287
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Mycobacterium ulcerans polyketide synthase 0.0026 0.0221 0.059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0038 0.0399 0.0399
Brugia malayi CXXC zinc finger family protein 0.0028 0.0255 0.0514
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0127 0.0211
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0049 0.0568 0.1146
Echinococcus multilocularis cpg binding protein 0.0032 0.0307 0.0307
Schistosoma mansoni DNA polymerase eta 0.0019 0.0117 0.0117
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0261 0.0527
Echinococcus granulosus neuropeptide receptor A26 0.049 0.7128 0.7128
Onchocerca volvulus 0.0184 0.2566 0.7595
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0804 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0281 0.3951
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.015 0.0304
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0069 0.0788
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0198 0.083
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0198 0.083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0532 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.015 0.015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.015 0.015
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0031 0.0287 0.0579
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0188 0.0188
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.015 0.015
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0255 0.0255
Loa Loa (eye worm) MBCTL1 0.0054 0.0632 0.1275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.015 0.015
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Brugia malayi PHD-finger family protein 0.0026 0.0223 0.0449
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0174 0.0352
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0632 0.0632
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0675 0.1378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0198 0.0499
Brugia malayi mbt repeat family protein 0.0047 0.0534 0.1078
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0493 0.1076
Schistosoma mansoni cpg binding protein 0.0028 0.0255 0.0255
Echinococcus multilocularis Endonuclease G 0.0019 0.0122 0.0122
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0261 0.0261
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0221 0.0785
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0117 0.1144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0534 0.1078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.015 0.015
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0184 0.2566 0.6057
Schistosoma mansoni microtubule-associated protein tau 0.0683 1 1
Brugia malayi Pre-SET motif family protein 0.003 0.0281 0.0566
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0395 0.0395
Brugia malayi Bromodomain containing protein 0.0076 0.0961 0.1939
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0117 0.0174
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0032 0.0314 0.0634
Echinococcus granulosus GPCR family 2 0.0048 0.0546 0.0546
Schistosoma mansoni cpg binding protein 0.0032 0.0307 0.0307
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0117 0.0237
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0184 0.2566 0.6057
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0131 0.048
Echinococcus granulosus dna polymerase kappa 0.0019 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0031 0.0287 0.0287
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0735 0.0735
Trypanosoma brucei endonuclease G, putative 0.0019 0.0122 0.1199
Echinococcus granulosus caspase 2 0.0031 0.0287 0.0287
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0117 0.0117
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0019 0.0122 0.1569
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1239 0.1239
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.015 0.0304
Trypanosoma cruzi endonuclease G, putative 0.0019 0.0122 0.0865
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0546 0.1103
Loa Loa (eye worm) hypothetical protein 0.004 0.0432 0.0871
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0804 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0804 0.0804
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0632 0.0632
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.5859 0.5859
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0095 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.015 0.015
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0184 0.2566 0.6057
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0081 0.0957
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0146 0.0294
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1231 0.1231
Onchocerca volvulus 0.0031 0.0287 0.0429
Plasmodium falciparum phd finger protein, putative 0.0029 0.0261 1
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0137 0.0253
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0019 0.0122 0.0865
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0198 0.083
Brugia malayi Pre-SET motif family protein 0.0207 0.2907 0.5867
Onchocerca volvulus 0.0023 0.0174 0.0075
Trypanosoma brucei endonuclease G, putative 0.0019 0.0122 0.1199
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0184 0.2566 0.6057
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0127 0.1723 0.883
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0174 0.0352
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0187 0.0771
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0117 0.0117
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0193 0.039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.015 0.015
Echinococcus granulosus geminin 0.0516 0.7512 0.7512
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0287 0.0287
Brugia malayi nuclear hormone receptor 0.0021 0.015 0.0304
Schistosoma mansoni hypothetical protein 0.0287 0.4104 0.4104
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0081 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0745 0.0745
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0281 0.0281
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0117 0.0117
Schistosoma mansoni coup transcription factor 0.0021 0.015 0.015
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0804 0.1699
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0281 0.0281
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.015 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.015 0.0304
Brugia malayi Bromodomain containing protein 0.0031 0.0296 0.0597
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0081 0.0673
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0675 0.8328
Onchocerca volvulus 0.0047 0.0534 0.1207
Schistosoma mansoni hypothetical protein 0.0048 0.0546 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.015 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.015 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0404 0.0815
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.015 0.0304
Schistosoma mansoni hypothetical protein 0.0104 0.1376 0.1376
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0198 0.04
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1946 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0184 0.2566 0.6057
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Echinococcus multilocularis GPCR, family 2 0.0048 0.0546 0.0546
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0344 0.4956 0.4956
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0632 0.0632
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0184 0.2566 0.5179
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0221 0.095
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0675 0.1378
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Brugia malayi PHD-finger family protein 0.0013 0.0024 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0344 0.4956 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0534 0.0534
Onchocerca volvulus Alhambra homolog 0.0029 0.0261 0.0348
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0804 0.1623
Leishmania major DNA polymerase kappa, putative 0.0019 0.0117 0.0808
Leishmania major endonuclease G, putative 0.0019 0.0122 0.0865
Echinococcus granulosus neuropeptide s receptor 0.049 0.7128 0.7128
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.015 0.0304
Brugia malayi nuclear receptor NHR-88 0.0021 0.015 0.0304
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.015 0.0304
Onchocerca volvulus 0.003 0.0281 0.0409
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.038 0.1227
Brugia malayi ecdysteroid receptor 0.0021 0.015 0.0304
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0261 0.0261
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0344 0.4956 0.4956
Trypanosoma brucei unspecified product 0.0019 0.0117 0.1144
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.015 0.015
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0188 0.0188
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1239 0.1239
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.015 0.015
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0221 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0184 0.2566 0.5179
Echinococcus multilocularis microtubule associated protein 2 0.0683 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1231 0.1231
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0093 0.0093
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0032 0.0314 0.0314
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0137 0.0337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1231 0.1231
Schistosoma mansoni hypothetical protein 0.002 0.0136 0.0136
Echinococcus multilocularis caspase 2 0.0031 0.0287 0.0287
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0032 0.0314 0.0314
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0198 0.0664
Mycobacterium ulcerans polyketide synthase 0.0025 0.0198 0.0499
Giardia lamblia PHD finger protein 15 0.0029 0.0261 0.0356
Loa Loa (eye worm) hypothetical protein 0.0044 0.0484 0.0977
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0237
Onchocerca volvulus 0.0043 0.047 0.1005
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0804 0.0804
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Entamoeba histolytica hypothetical protein 0.0038 0.0399 0.0697
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0287 0.0429
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0081 0.0081
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0049
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0184 0.2566 0.6057
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0221 0.0785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0532 0.0532
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0184 0.2566 0.6057
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0198 0.0664
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0429 0.0429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.2091 0.422
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0117 0.0406
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0117 0.1144
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0081 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1231 0.2484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0187 0.0771
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0027 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.4161 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.015 0.0304
Brugia malayi jmjC domain containing protein 0.0094 0.1239 0.2499
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0532 0.1073
Echinococcus granulosus jumonji domain containing protein 0.004 0.0429 0.0429
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0117 0.0174
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0081 0.0957
Brugia malayi Thrombospondin type 1 domain containing protein 0.007 0.0874 0.1763
Brugia malayi hypothetical protein 0.0031 0.0287 0.0579
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0221 0.059
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0344 0.4956 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0399 0.0399
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0032 0.0314 0.0634
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0404 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.015 0.0304
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0221 0.306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.015 0.015
Echinococcus granulosus Endonuclease G 0.0019 0.0122 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.015 0.0304
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0081 0.0319
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.02 0.2806 0.2806
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0117 0.1144
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0221 0.059
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1946 0.7512
Schistosoma mansoni zinc finger protein 0.0021 0.0144 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.015 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0675 0.8264
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.4351 0.8779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1231 0.1231
Trypanosoma brucei ISWI complex protein 0.0015 0.0057 0.0365
Echinococcus multilocularis peregrin 0.0031 0.0296 0.0296
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0632 0.0632
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0632 0.1275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.015 0.015
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0287 0.0287
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.4161 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.038 0.1782
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0534 0.1078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0081 0.0081
Onchocerca volvulus 0.0235 0.3331 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0117 0.0808
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1946 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0022 0.0022
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0127 0.0281
Schistosoma mansoni hypothetical protein 0.0048 0.0546 0.0546
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.015 0.0304
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0081 0.0081
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0174 0.0704
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0404 0.0404
Schistosoma mansoni endonuclease related 0.0019 0.0122 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0532 0.0532
Brugia malayi isocitrate dehydrogenase 0.0017 0.0081 0.0163
Echinococcus granulosus zinc finger protein 0.0021 0.0144 0.0144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.015 0.015
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0534 0.1207
Echinococcus multilocularis neuropeptide s receptor 0.049 0.7128 0.7128
Schistosoma mansoni hypothetical protein 0.0516 0.7512 0.7512
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0137 0.051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0281 0.0281
Schistosoma mansoni thyroid hormone receptor 0.0021 0.015 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0117 0.1144
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0057
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0083 0.0083
Echinococcus multilocularis geminin 0.0516 0.7512 0.7512
Plasmodium vivax SET domain protein, putative 0.003 0.0281 1
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0719 0.145
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0032 0.0314 0.0314
Echinococcus multilocularis zinc finger protein 0.0021 0.0144 0.0144
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0019 0.0122 0.0865
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0534 0.0534
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0404 0.0404
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0081 0.0319
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.015 0.0304
Brugia malayi Bromodomain containing protein 0.0038 0.0396 0.0799
Brugia malayi hypothetical protein 0.0038 0.0399 0.0806
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.0801
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0081 0.0081
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.015 0.015
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0019 0.0122 0.0865
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0127 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0395 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.0808
Schistosoma mansoni zinc finger protein 0.0015 0.0057 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.015 0.0304
Trypanosoma cruzi endonuclease G, putative 0.0019 0.0122 0.0865
Brugia malayi endonuclease G, mitochondrial precursor 0.0019 0.0122 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.015 0.0304
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.2091 0.422
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0083 0.0083
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0534 0.0534
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1376 0.2777
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0675 0.8264
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0287 0.0579
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0093 0.1135
Onchocerca volvulus 0.0028 0.0255 0.0328
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0532 0.0532
Schistosoma mansoni hypothetical protein 0.0405 0.5859 0.5859
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.015 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.1144
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0092 0.0185
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0081 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4161 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0261 0.3659
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.0808
Entamoeba histolytica hypothetical protein 0.0038 0.0399 0.0697
Entamoeba histolytica hypothetical protein 0.0038 0.0399 0.0697
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Schistosoma mansoni hypothetical protein 0.0516 0.7512 0.7512
Onchocerca volvulus 0.007 0.0874 0.2274
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0083 0.0083
Brugia malayi steroid hormone receptor 0.0021 0.015 0.0304
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.015 0.015
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0198 0.0499
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0048 0.0546 0.1103
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0221 0.095
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0198 0.0499
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.015 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0546 0.0546
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0117 0.0808
Schistosoma mansoni nuclear hormone receptor 0.0021 0.015 0.015
Brugia malayi mbt repeat family protein 0.0047 0.0534 0.1078
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0198 0.0499
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0038 0.0399 0.0697
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.015 0.015
Onchocerca volvulus 0.0032 0.0314 0.0515
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0255 0.0514
Loa Loa (eye worm) hypothetical protein 0.0054 0.0632 0.1275
Echinococcus granulosus cpg binding protein 0.0032 0.0307 0.0307
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.007 0.0874 0.1763
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.038 0.1782
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0081 0.0673
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0304
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0081 0.0163
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0027 0.0238 0.0238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.0808
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0399 0.0399
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0032 0.0314 0.0314
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0527
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0117 0.0406
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0261 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.015 0.0304
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0546 0.0546
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.0808
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0117 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.015 0.0304
Echinococcus multilocularis dna polymerase eta 0.0019 0.0117 0.0117
Schistosoma mansoni cpg binding protein 0.0032 0.0307 0.0307
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0804 1
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0184 0.2566 0.6057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.015 0.015
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0804 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.015 0.0304
Schistosoma mansoni hypothetical protein 0.0029 0.0261 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.015 0.0304
Loa Loa (eye worm) hypothetical protein 0.0041 0.0448 0.0904
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0804 0.1623
Echinococcus granulosus ectonucleotide 0.0027 0.0238 0.0238
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0083 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0361 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.015 0.0304
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0221 0.0785
Schistosoma mansoni hypothetical protein 0.0048 0.0546 0.0546
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0184 0.2566 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.015 0.015
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0949 0.0949
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.015 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1231 0.1231
Schistosoma mansoni hypothetical protein 0.0024 0.0191 0.0191
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0188 0.0188
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0546 0.1103
Trypanosoma brucei endonuclease G, putative 0.0019 0.0122 0.1199
Echinococcus granulosus dnaJ subfamily B 0.0405 0.5859 0.5859
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0184 0.2566 0.6057
Trichomonas vaginalis set domain proteins, putative 0.0235 0.3331 0.7949
Echinococcus granulosus FTZ F1 alpha 0.0021 0.015 0.015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.4161 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0527 0.1063
Loa Loa (eye worm) hypothetical protein 0.007 0.0874 0.1763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1231 0.1231
Leishmania major hypothetical protein, conserved 0.0057 0.0675 0.8264
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2907 0.5867
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0546 0.1103
Brugia malayi PHD-finger family protein 0.0029 0.0261 0.0527
Mycobacterium ulcerans thioesterase 0.0021 0.0137 0.0253

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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