Detailed information for compound 594433

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.363 | Formula: C14H14N6O6S
  • H donors: 4 H acceptors: 9 LogP: 0.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OS(=O)(=O)O.Nc1nc(N)c2c(n1)ncc(c2)Cc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C14H12N6O2.H2O4S/c15-12-11-6-9(7-17-13(11)19-14(16)18-12)5-8-1-3-10(4-2-8)20(21)22;1-5(2,3)4/h1-4,6-7H,5H2,(H4,15,16,17,18,19);(H2,1,2,3,4)
  • InChiKey: USUUWMAJNKAGFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0025 0.0055 0.0067
Loa Loa (eye worm) beta-lactamase 0.0071 0.0662 0.126
Schistosoma mansoni immunophilin 0.0054 0.0431 0.0821
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0195 0.0171
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.2542 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0055 0.0064
Brugia malayi Ets-domain containing protein 0.0071 0.0658 0.1218
Onchocerca volvulus 0.0079 0.0765 0.1939
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0195 0.0465
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0195 0.0873
Toxoplasma gondii cathepsin CPL 0.0079 0.0765 0.4419
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0492 0.6328
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0662 0.1108
Brugia malayi Cathepsin L-like precursor 0.0079 0.0765 0.1422
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0506 0.092
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0384 0.0694
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0055 0.0045
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0492 0.1813
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.035 0.0326
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0725 0.1345
Brugia malayi beta-lactamase 0.0071 0.0662 0.1225
Plasmodium vivax vivapain-2 0.0079 0.0765 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0384 0.1091
Brugia malayi Cathepsin L-like precursor 0.0079 0.0765 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.3076 0.5854
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0055 0.0451
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0492 0.1447
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0206 0.067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0662 0.1108
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0492 0.0287
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0424 0.5254 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0384 0.1091
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0054 0.0431 0.2342
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0148 0.1663 0.5323
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0343 0.1217
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.2999 0.5688
Onchocerca volvulus Cathepsin F homolog 0.0079 0.0765 0.1939
Echinococcus granulosus cathepsin L 0.0025 0.0055 0.0057
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0343 0.4054
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0335 0.0311
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0055 0.0104
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0436 0.0412
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Loa Loa (eye worm) hypothetical protein 0.0071 0.0662 0.126
Brugia malayi 6-phosphofructokinase 0.0216 0.2542 0.4818
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0206 0.0391
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0384 0.0687
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0138 0.0224
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0662 0.1225
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0384 0.036
Loa Loa (eye worm) hypothetical protein 0.0071 0.0662 0.126
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Loa Loa (eye worm) MBCTL1 0.0054 0.0436 0.0829
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0662 0.2011
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0662 0.8614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0431 0.0407
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0079 0.0765 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0055 0.0067
Echinococcus multilocularis cathepsin b 0.0424 0.5254 0.5242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Leishmania major peptidylprolyl isomerase-like protein 0.0054 0.0431 0.1571
Onchocerca volvulus 0.0057 0.0477 0.1171
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0765 0.0742
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0662 0.2492
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0424 0.5254 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0054 0.0431 0.0777
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0765 0.2904
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0492 0.272
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2044 0.6586
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0364 0.0693
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0765 0.0742
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0662 0.1108
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0384 0.0694
Brugia malayi Bromodomain containing protein 0.0075 0.0704 0.1305
Plasmodium vivax unspecified product 0.0047 0.0343 0.4322
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0195 0.0465
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.2542 0.4838
Schistosoma mansoni hypothetical protein 0.0352 0.4311 0.8204
Echinococcus multilocularis cathepsin L 0.0025 0.0055 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Loa Loa (eye worm) hypothetical protein 0.0041 0.026 0.0495
Onchocerca volvulus 0.0093 0.0937 0.2398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Leishmania major hypothetical protein, conserved 0.0071 0.0662 0.2492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0662 0.2492
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0662 0.126
Mycobacterium ulcerans 6-phosphofructokinase 0.0216 0.2542 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0662 0.1108
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0079 0.0765 0.1456
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0902 0.0879
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0902 0.1716
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1815 0.3455
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.2542 0.4838
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0193 0.0321
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0343 0.1217
Echinococcus granulosus cathepsin l cysteine peptidase 0.0079 0.0765 0.1416
Brugia malayi fibroinase precursor 0.0025 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0104
Schistosoma mansoni ap endonuclease 0.0076 0.0725 0.138
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0662 0.2011
Schistosoma mansoni survival motor neuron protein 0.0051 0.0399 0.076
Entamoeba histolytica cysteine protease, putative 0.0025 0.0055 0.0067
Loa Loa (eye worm) hypothetical protein 0.0067 0.0608 0.1158
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0436 0.0786
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Schistosoma mansoni hypothetical protein 0.0031 0.0138 0.0263
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0492 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3076 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0195 0.0465
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0436 0.0829
Loa Loa (eye worm) hypothetical protein 0.0071 0.0662 0.126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0021 0.004
Brugia malayi hypothetical protein 0.0312 0.3788 0.7199
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0138 0.0263
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0079 0.0765 1
Schistosoma mansoni hypothetical protein 0.0035 0.0193 0.0367
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0343 0.1217
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0662 0.2011
Onchocerca volvulus 0.0079 0.0765 0.1939
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0054 0.0431 0.0821
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Onchocerca volvulus 0.0071 0.0662 0.1664
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0662 0.1219
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.5668 1
Schistosoma mansoni cathepsin C 0.0025 0.0055 0.0104
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0492 0.272
Brugia malayi cathepsin B-like cysteine proteinase 0.0424 0.5254 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0054 0.0431 0.1007
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0055 0.0451
Loa Loa (eye worm) hypothetical protein 0.0071 0.0662 0.126
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0343 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0765 0.2352
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0055 0.0104
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0384 0.0731
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0343 0.0652
Schistosoma mansoni immunophilin 0.0054 0.0431 0.0821
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0384 0.1091
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0343 0.0615
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0384 0.0687
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0055 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3076 1
Trichomonas vaginalis fk506-binding protein, putative 0.0054 0.0431 0.1247
Loa Loa (eye worm) FKBP5 protein 0.0054 0.0431 0.0821
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0725 0.2258
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0424 0.5254 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.1525 0.2903
Loa Loa (eye worm) hypothetical protein 0.0038 0.023 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Mycobacterium tuberculosis Conserved protein 0.0071 0.0662 0.1108
Loa Loa (eye worm) hypothetical protein 0.0071 0.0662 0.126
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.2542 0.8234
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0072
Echinococcus granulosus cathepsin l1 0.0079 0.0765 0.1416
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0206 0.0939
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0662 0.2011
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0206 0.0181
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0436 0.0793
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0195 0.0465
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0384 0.1091
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0193 0.0367
Brugia malayi Cathepsin L-like precursor 0.0079 0.0765 0.1422
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0055 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0343 0.1217
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0662 0.1108
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0725 0.2219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0765 0.1939
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0054 0.0431 0.1247
Plasmodium falciparum cysteine proteinase falcipain 3 0.0079 0.0765 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0055 0.0451
Echinococcus granulosus cysteine protease 0.0047 0.0343 0.0608
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0725 0.1392
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0384 0.1383
Mycobacterium tuberculosis Conserved protein 0.0071 0.0662 0.1108
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0206 0.067
Mycobacterium tuberculosis Conserved protein 0.0071 0.0662 0.1108
Brugia malayi beta-lactamase family protein 0.0071 0.0662 0.1225
Echinococcus granulosus cathepsin l1 0.0057 0.0477 0.0865
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0662 0.2011
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0492 0.6154
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0608 0.1122
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.2542 0.4818
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0195 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0055 0.0104
Onchocerca volvulus 0.0079 0.0765 0.1939
Brugia malayi mbt repeat family protein 0.0047 0.035 0.0629
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0436 0.0412
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0054 0.0431 0.0784
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0055 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0055 0.0104
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0054 0.0431 0.0784
Onchocerca volvulus 0.0047 0.035 0.0833
Schistosoma mansoni hypothetical protein 0.0031 0.0138 0.0263
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0055 0.0104
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.2542 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0285 0.0542
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0658 0.1212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0055 0.0451
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0431 0.0777
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0054 0.0431 0.5301
Onchocerca volvulus 0.0071 0.0662 0.1664
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.004
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.0618
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0055 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0055 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0765 0.1422
Loa Loa (eye worm) cysteine protease 0.0079 0.0765 0.1456
Loa Loa (eye worm) hypothetical protein 0.0057 0.0477 0.0908
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0055 0.0451
Onchocerca volvulus 0.0312 0.3788 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.035 0.0667
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0195 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0195 0.0465
Loa Loa (eye worm) hypothetical protein 0.0057 0.0477 0.0908
Brugia malayi Bromodomain containing protein 0.0038 0.0229 0.0397
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0054 0.0431 0.0784
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0206 0.0045
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0055 0.0451
Brugia malayi MAP kinase sur-1 0.005 0.0384 0.0694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0902 0.1677
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0436 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0662 0.1225
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0492 0.1447
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.004
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0054 0.0431 0.0784
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0477 0.1398
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0384 0.1383
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0195 0.0326
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0332
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.076
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0765 0.0742
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0195 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0492 0.272
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0206 0.0353
Echinococcus granulosus GPCR family 2 0.0031 0.0138 0.0217
Onchocerca volvulus 0.0079 0.0765 0.1939
Echinococcus granulosus cathepsin L cysteine proteinase 0.0079 0.0765 0.1416
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0054 0.0431 0.1571
Loa Loa (eye worm) hypothetical protein 0.0098 0.1013 0.1929
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0662 0.0639
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0138 0.0217
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0216 0.2542 1
Entamoeba histolytica hypothetical protein 0.0025 0.0055 0.0067
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.0618
Loa Loa (eye worm) ctsf protein 0.0079 0.0765 0.1456
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.0618
Loa Loa (eye worm) phosphofructokinase 0.0216 0.2542 0.4838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0902 0.0879
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3076 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0057 0.0477 0.0908
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0765 0.1422
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Schistosoma mansoni immunophilin 0.0046 0.0335 0.0638
Echinococcus granulosus cathepsin b 0.0424 0.5254 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0343 0.0615
Mycobacterium leprae Probable lipase LipE 0.0071 0.0662 0.2492
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0506 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0765 0.1422
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0104
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0054 0.0431 0.0821
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0206 0.0346
Trypanosoma brucei cysteine peptidase C (CPC) 0.0148 0.1663 0.6253
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.2542 0.8234
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.2366 0.2347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0902 0.1716
Schistosoma mansoni gabp alpha 0.0071 0.0658 0.1253
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0725 0.122
Entamoeba histolytica hypothetical protein 0.0035 0.0193 0.0618
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0765 0.1456
Leishmania major ATP-dependent phosphofructokinase 0.0216 0.2542 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0492 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0055 0.0104
Echinococcus multilocularis cathepsin L 0.0047 0.0343 0.0319
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0424 0.5254 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0055 0.0064
Echinococcus granulosus geminin 0.0352 0.4311 0.8196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2044 0.6586
Brugia malayi Cytochrome P450 family protein 0.0049 0.0364 0.0656
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0725 0.2744
Entamoeba histolytica cysteine protease, putative 0.0025 0.0055 0.0067
Onchocerca volvulus 0.0079 0.0765 0.1939
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0343 0.1217
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0198 0.0331
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0138 0.0217
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1815 0.3428
Brugia malayi Ets-domain containing protein 0.0071 0.0658 0.1218
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0054 0.0431 0.1571
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0492 0.1447
Brugia malayi beta-lactamase family protein 0.0071 0.0662 0.1225
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1013 0.1896
Loa Loa (eye worm) hypothetical protein 0.0424 0.5254 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0148 0.1663 0.3164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0725 0.1345
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0055 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.2542 0.8234
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.2542 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0054 0.0431 0.0784
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0032
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0206 0.05
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0206 0.0391
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0206 0.0181
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0765 0.1456
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0725 0.9435
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0055 0.0451
Brugia malayi PHD-finger family protein 0.0025 0.0055 0.0066
Loa Loa (eye worm) hypothetical protein 0.0054 0.0436 0.0829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0902 0.1716
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0148 0.1663 0.6488
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1815 0.1795
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Echinococcus multilocularis cysteine protease 0.0079 0.0765 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0477 0.1398
Toxoplasma gondii exonuclease III APE 0.0076 0.0725 0.4169
Loa Loa (eye worm) hypothetical protein 0.0312 0.3788 0.721
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0343 0.0652
Loa Loa (eye worm) fibroinase 0.0079 0.0765 0.1456
Trichomonas vaginalis esterase, putative 0.0071 0.0662 0.2011
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0055 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.2542 0.8234
Echinococcus multilocularis GPCR, family 2 0.0031 0.0138 0.0114
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0055 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0424 0.5254 1
Toxoplasma gondii ABC1 family protein 0.0071 0.0662 0.3777
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0384 0.2049
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0055 0.0064
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0477 0.0871
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0902 0.1716
Echinococcus multilocularis cysteine protease 0.0079 0.0765 0.0742
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0492 0.1447
Loa Loa (eye worm) fli-1 protein 0.0216 0.2543 0.4839
Onchocerca volvulus 0.0079 0.0765 0.1939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0055 0.0104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0055 0.0104
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0662 0.2492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0662 0.126
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0055 0.0104
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.3076 0.5838
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0343 0.0615
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0725 0.2744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.2542 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0138 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0492 0.1447
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0055 0.0104
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0025 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0216 0.2542 1
Schistosoma mansoni hypothetical protein 0.0031 0.0138 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0391
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0384 0.036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0195 0.0627
Echinococcus multilocularis fk506 binding protein 0.0054 0.0431 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0206 0.05
Brugia malayi 6-phosphofructokinase 0.0216 0.2542 0.4818
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0104
Brugia malayi phosphofructokinase 0.0216 0.2542 0.4818
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1013 0.1929
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0725 0.138
Schistosoma mansoni hypothetical protein 0.0067 0.0608 0.1158
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0725 0.1345
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1815 0.1795
Onchocerca volvulus 0.0051 0.0399 0.0963
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0902 0.1677
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0662 0.1225
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0658 0.1253
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0148 0.1663 0.3137
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0492 0.1447
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0765 0.2904
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0072
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.035 0.0667
Mycobacterium ulcerans beta-lactamase 0.0071 0.0662 0.2492
Trypanosoma brucei protein kinase, putative 0.005 0.0384 0.0806
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0206 0.0353
Brugia malayi cathepsin L-like precursor 0.0057 0.0477 0.0871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0765 0.2352
Loa Loa (eye worm) hypothetical protein 0.0251 0.2999 0.5708
Plasmodium vivax unspecified product 0.0025 0.0055 0.0451
Mycobacterium ulcerans lipase LipD 0.0071 0.0662 0.2492
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0477 0.0871
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0725 0.2744
Loa Loa (eye worm) cathepsin B 0.0148 0.1663 0.3164
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0055 0.0064
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0055 0.0104
Echinococcus granulosus 6 phosphofructokinase 0.0216 0.2542 0.4814
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0343 0.0652
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0343 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Brugia malayi Cathepsin L-like precursor 0.0079 0.0765 0.1422
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0195 0.0465
Brugia malayi mbt repeat family protein 0.0047 0.035 0.0629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0765 0.0742
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.035 0.0623
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0055 0.0451
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0492 0.6154
Loa Loa (eye worm) hypothetical protein 0.0061 0.0524 0.0998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0343 0.0615
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0195 0.0465
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0206 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0138 0.0263
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1815 0.3424
Giardia lamblia Cathepsin B precursor 0.0148 0.1663 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0343 0.1217
Schistosoma mansoni alpha glucosidase 0.0035 0.0195 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0765 0.2352
Toxoplasma gondii cathepsin B 0.0148 0.1663 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0055 0.0067
Schistosoma mansoni ap endonuclease 0.0076 0.0725 0.138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0343 0.0629
Echinococcus granulosus cathepsin L 0.0047 0.0343 0.0608
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0765 0.1939
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0384 0.0694
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0492 0.1447
Loa Loa (eye worm) hypothetical protein 0.0047 0.035 0.0667
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0399 0.0723
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0662 0.1108
Onchocerca volvulus 0.0079 0.0765 0.1939
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0335 0.0594
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0384 0.2049
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0343 0.0608
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3076 1
Schistosoma mansoni cathepsin s 0.0022 0.0021 0.004
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.2542 0.4838
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0054 0.0431 0.5512
Echinococcus multilocularis geminin 0.0352 0.4311 0.4296
Giardia lamblia Cathepsin B precursor 0.0148 0.1663 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0195 0.0371
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.035 0.0833
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0055 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0343 0.0954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0195 0.0627
Loa Loa (eye worm) hypothetical protein 0.0079 0.0765 0.1456
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0492 0.272
Entamoeba histolytica cysteine protease, putative 0.0079 0.0765 0.2904
Schistosoma mansoni hypothetical protein 0.0031 0.0138 0.0263
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0055 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0765 0.1422
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0055 0.0451
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0477 0.1754
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0332
Schistosoma mansoni bromodomain containing protein 0.0063 0.0552 0.1051
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.0725 0.4169
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0725 0.1339
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.035 0.0326
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1926 0.6195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.035 0.0667
Brugia malayi Cathepsin L-like precursor 0.0057 0.0477 0.0871
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0054 0.0431 0.0784
Brugia malayi Fli-1 protein 0.0216 0.2543 0.4819
Leishmania major cathepsin L-like protease 0.0079 0.0765 0.2904
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.035 0.0623
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0902 0.1683
Echinococcus granulosus cathepsin b 0.0424 0.5254 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0384 0.0806
Onchocerca volvulus 0.0025 0.0055 0.0045
Leishmania major fk506-binding protein 1-like protein 0.0054 0.0431 0.1571
Plasmodium vivax vivapain-1 0.0047 0.0343 0.4322
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0054 0.0431 0.1007
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0055 0.0104
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0662 0.199
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0055 0.0064
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0492 0.6328
Echinococcus multilocularis 6 phosphofructokinase 0.0216 0.2542 0.2524
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0343 0.0615
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0206 0.0353
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1013 0.1896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0343 0.0954
Brugia malayi hypothetical protein 0.0251 0.2999 0.5691
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1926 0.5036
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0384 0.0731
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0054 0.0431 0.1571
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0662 0.126
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0138 0.0114
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0384 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0206 0.05
Brugia malayi hypothetical protein 0.0035 0.0193 0.0328
Plasmodium vivax vivapain-2 0.0079 0.0765 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.0662 0.2492
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.2542 0.4838
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0765 0.1422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0343 0.0629
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0725 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.2999 0.2982
Plasmodium vivax vivapain-3 0.0047 0.0343 0.4322
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Loa Loa (eye worm) hypothetical protein 0.0071 0.0662 0.126
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0725 0.2219
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0195 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3076 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0765 0.2429
Entamoeba histolytica cysteine protease, putative 0.0047 0.0343 0.1217
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0765 0.1422
Brugia malayi cathepsin L precursor 0.0025 0.0055 0.0064
Schistosoma mansoni ets-related 0.0216 0.2543 0.4839
Entamoeba histolytica cysteine protease, putative 0.0025 0.0055 0.0067
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0658 0.0635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0193 0.0168
Brugia malayi Cathepsin L-like precursor 0.0057 0.0477 0.0871
Loa Loa (eye worm) hypothetical protein 0.0046 0.0335 0.0638
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0662 0.1108
Giardia lamblia Cathepsin B precursor 0.0148 0.1663 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.1525 0.2903
Trichomonas vaginalis immunophilin, putative 0.0054 0.0431 0.1247
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0138 0.0114
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0477 0.0908
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0198 0.0174
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.2366 0.4478
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0765 0.1456
Loa Loa (eye worm) hypothetical protein 0.007 0.0648 0.1234
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0216 0.2542 0.4448
Brugia malayi Cathepsin L-like precursor 0.0079 0.0765 0.1422
Brugia malayi Cathepsin L-like precursor 0.0079 0.0765 0.1422
Schistosoma mansoni hypothetical protein 0.0304 0.3687 0.7017
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0054 0.0431 0.2342
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0206 0.0346
Onchocerca volvulus 0.0071 0.0662 0.1664
Leishmania major cysteine peptidase A (CPA) 0.0079 0.0765 0.2904
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.035 0.0667
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0054 0.0431 0.1247
Entamoeba histolytica cysteine protease, putative 0.0025 0.0055 0.0067
Echinococcus multilocularis cathepsin b 0.0424 0.5254 0.5242
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3076 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0206 0.0346
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.0725 0.5
Schistosoma mansoni hypothetical protein 0.0352 0.4311 0.8204
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0725 0.946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0765 0.2352

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -2.65 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = -0.27 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.37 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 91 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0.85 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 0 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 91 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.03 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.94319 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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