Detailed information for compound 646834

Basic information

Technical information
  • TDR Targets ID: 646834
  • Name: 3-(5,7-dichloro-1,3-benzoxazol-2-yl)aniline
  • MW: 279.121 | Formula: C13H8Cl2N2O
  • H donors: 1 H acceptors: 1 LogP: 4 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(Cl)c2c(c1)nc(o2)c1cccc(c1)N
  • InChi: 1S/C13H8Cl2N2O/c14-8-5-10(15)12-11(6-8)17-13(18-12)7-2-1-3-9(16)4-7/h1-6H,16H2
  • InChiKey: IYAWIRITEWPMIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-(5,7-dichloro-1,3-benzoxazol-2-yl)phenyl]amine
  • 6343-13-1
  • SBB001124
  • ZINC00125071

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0041 0.003 0.003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0015 0.041
Echinococcus granulosus expressed protein 0.0018 0.0006 0.0006
Brugia malayi intermediate filament protein 0.0026 0.0015 0.008
Brugia malayi Niemann-Pick C1 protein precursor 0.0191 0.0187 0.117
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0064 0.0201
Schistosoma mansoni apoferritin-2 0.0018 0.0006 0.0002
Echinococcus granulosus Protein patched homolog 1 0.0082 0.0073 0.0073
Trichomonas vaginalis importin beta-1, putative 0.0018 0.0006 0.0022
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0073 0.0064 0.0205
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0022 0.1722
Echinococcus granulosus nibrin 0.0017 0.0005 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0077 0.0068 0.043
Schistosoma mansoni survival motor neuron protein 0.0311 0.0313 0.0309
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0004 0.0014
Brugia malayi jmjC domain containing protein 0.0072 0.0063 0.0386
Schistosoma mansoni lamin 0.0026 0.0015 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0249 0.0248 0.085
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0005 0.0001
Treponema pallidum NADH oxidase 0.0027 0.0015 0.041
Echinococcus multilocularis peptidase Clp (S14 family) 0.0166 0.0161 0.016
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.0064 0.5239
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0079 0.297
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0022 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0171 0.0578
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0176 0.0172 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0015 0.014
Echinococcus multilocularis Niemann Pick C1 protein 0.0273 0.0273 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0069 0.022
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0011 0.0169
Mycobacterium ulcerans hypothetical protein 0.0078 0.0069 0.0224
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0008 0.0037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0194 0.019 0.0186
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0015 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0176 0.0172 0.058
Brugia malayi glutathione reductase 0.0077 0.0068 0.0418
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0073 0.0884
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0069 0.0069
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0015 0.0143
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0005 0.0294
Echinococcus granulosus peptidase Clp S14 family 0.0166 0.0161 0.016
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0069 0.0834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0005 0.0096
Schistosoma mansoni patched 1 0.0082 0.0073 0.0069
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0015 0.0035
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0022 0.0022
Brugia malayi glutaminase DH11.1 0.0207 0.0204 0.1278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0088 0.0084
Trypanosoma cruzi transcription factor btf3, putative 0.0026 0.0015 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0033
Loa Loa (eye worm) fibroinase 0.0033 0.0022 0.014
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.001 0.0521
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0005 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.0064 0.252
Loa Loa (eye worm) hypothetical protein 0.0096 0.0088 0.0556
Brugia malayi latrophilin 2 splice variant baaae 0.0089 0.008 0.0495
Onchocerca volvulus 0.0033 0.0022 0.0218
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0015 0.0015
Trichomonas vaginalis set domain proteins, putative 0.076 0.0783 1
Entamoeba histolytica Flap nuclease, putative 0.003 0.0019 0.0383
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Schistosoma mansoni lamin 0.0026 0.0015 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0088 0.0084
Echinococcus multilocularis transcription factor btf3 0.0026 0.0015 0.0015
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0006 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0015 0.0035
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0015 0.045
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0069 0.0834
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0015 0.045
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0004 0.02
Brugia malayi beta-lactamase family protein 0.0078 0.0069 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0015 0.0964
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.012 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0249 0.0248 0.0847
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0029 0.0182
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.071 0.0731 0.0727
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0015 0.1144
Schistosoma mansoni hypothetical protein 0.0089 0.008 0.0076
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0022 0.0022
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0064 0.0205
Brugia malayi beta-lactamase 0.0078 0.0069 0.0424
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0069 0.022
Leishmania major importin beta-1 subunit, putative 0.0018 0.0006 0.0166
Onchocerca volvulus 0.0078 0.0069 0.0821
Trichomonas vaginalis replication factor C large subunit, putative 0.0017 0.0005 0.0013
Mycobacterium ulcerans glutaminase 0.0207 0.0204 0.0698
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0186 0.0182 0.7153
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0006 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0029 0.0028
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0079 0.3
Brugia malayi Probable ClpP-like protease 0.0253 0.0252 0.1581
Brugia malayi topoisomerase 0.0017 0.0005 0.0021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0253 0.0252 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0015 0.0035
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0073 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.013 0.0123 0.0778
Schistosoma mansoni apoferritin-2 0.0018 0.0006 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.0192 0.0652
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0005 0.0029
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0166 0.0161 0.0542
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Brugia malayi Cathepsin L-like precursor 0.0033 0.0022 0.0128
Loa Loa (eye worm) ICD-1 protein 0.0026 0.0015 0.0095
Onchocerca volvulus Huntingtin homolog 0.0106 0.0099 0.1201
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0017 0.0005 0.0289
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 1
Giardia lamblia Replication factor C, subunit 1 0.0017 0.0005 0.0714
Plasmodium vivax importin-beta 2, putative 0.0022 0.001 0.0244
Schistosoma mansoni chromosome transmission fidelity factor 0.0017 0.0005 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.1144
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0015 0.0143
Onchocerca volvulus 0.0073 0.0064 0.0753
Leishmania major 4-coumarate:coa ligase-like protein 0.0249 0.0248 1
Echinococcus granulosus sterol regulatory element binding protein 0.0082 0.0073 0.0073
Toxoplasma gondii hypothetical protein 0.0087 0.0079 0.3
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0006 0.0028
Echinococcus multilocularis replication factor c subunit 1 0.0017 0.0005 0.0005
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0017 0.0005 0.0013
Mycobacterium ulcerans transcriptional regulator 0.2739 0.2858 1
Brugia malayi Latrophilin receptor protein 2 0.0041 0.003 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0014
Echinococcus multilocularis cpg binding protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0064 0.0402
Echinococcus granulosus lamin dm0 0.0026 0.0015 0.0014
Echinococcus multilocularis snurportin 1 0.0233 0.0232 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0069 0.569
Schistosoma mansoni cpg binding protein 0.0023 0.0011 0.0007
Onchocerca volvulus 0.0033 0.0022 0.0218
Plasmodium falciparum basic transcription factor 3b, putative 0.0026 0.0015 0.044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0088 0.3382
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0073 0.0064 0.2403
Brugia malayi hypothetical protein 0.0017 0.0005 0.0021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0006 0.0192
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0006 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Plasmodium falciparum thioredoxin reductase 0.0027 0.0015 0.045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0006 0.0048
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0015 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0249 0.0248 0.085
Echinococcus granulosus survival motor neuron protein 1 0.1524 0.1585 0.1584
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0073 0.0064 0.2403
Onchocerca volvulus 0.0033 0.0022 0.0218
Brugia malayi jmjC domain containing protein 0.0028 0.0017 0.0093
Plasmodium vivax vivapain-2 0.0033 0.0022 0.0726
Schistosoma mansoni hypothetical protein 0.0079 0.007 0.0066
Loa Loa (eye worm) glutaminase 2 0.0207 0.0204 0.1289
Brugia malayi Pax transcription activation domain interacting protein 0.0017 0.0005 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0028 0.0017 0.0012
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0073 0.0064 0.2403
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0022 0.0018
Brugia malayi Flap endonuclease-1 0.003 0.0019 0.0107
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0017 0.0105
Loa Loa (eye worm) glutaminase 0.0207 0.0204 0.1289
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0015 0.014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0028 0.0017 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.001 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.1144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.1144
Giardia lamblia PHD finger protein 15 0.0022 0.001 0.4276
Schistosoma mansoni hypothetical protein 0.0041 0.003 0.0026
Leishmania major hypothetical protein, conserved 0.0078 0.0069 0.2737
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.009
Schistosoma mansoni hypothetical protein 0.0233 0.0232 0.0228
Leishmania major trypanothione reductase 0.0077 0.0068 0.2699
Loa Loa (eye worm) hypothetical protein 0.0253 0.0252 0.1592
Entamoeba histolytica hypothetical protein 0.0383 0.0389 1
Onchocerca volvulus 0.0073 0.0064 0.0753
Loa Loa (eye worm) hypothetical protein 0.0078 0.0069 0.0436
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0064 0.0391
Onchocerca volvulus 0.0073 0.0064 0.0753
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0006 0.0022
Schistosoma mansoni hypothetical protein 0.0383 0.0389 0.0385
Echinococcus multilocularis tumor protein p63 0.287 0.2995 0.2994
Schistosoma mansoni hypothetical protein 0.0079 0.007 0.0066
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 1
Onchocerca volvulus 0.076 0.0783 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.001 0.0254
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0069 0.0069
Plasmodium falciparum replication factor C subunit 1, putative 0.0017 0.0005 0.0042
Echinococcus multilocularis flap endonuclease 1 0.003 0.0019 0.0018
Mycobacterium tuberculosis Conserved protein 0.0078 0.0069 0.022
Brugia malayi Calcitonin receptor-like protein seb-1 0.013 0.0123 0.0766
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0006 0.0388
Echinococcus granulosus transcription factor btf3 0.0026 0.0015 0.0015
Echinococcus granulosus PHD finger protein rhinoceros 0.0022 0.001 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0191 0.0187 0.0187
Entamoeba histolytica hypothetical protein 0.0018 0.0006 0.0045
Schistosoma mansoni hypothetical protein 0.0079 0.007 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0014
Plasmodium vivax vivapain-2 0.0033 0.0022 0.0726
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0073 0.0064 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0088 0.0084
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0069 0.0436
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0048 0.0043
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0006 0.0048
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0017 0.0005 0.0027
Brugia malayi Cathepsin L-like precursor 0.0022 0.0011 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0064 0.0391
Entamoeba histolytica hypothetical protein 0.0383 0.0389 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0034 0.121
Echinococcus multilocularis cysteine protease 0.0033 0.0022 0.0022
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1571 0.1633 0.1633
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0006 0.0058
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0064 0.252
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0191
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0166 0.0161 0.0542
Onchocerca volvulus 0.0026 0.0015 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0015 0.0092
Leishmania major cathepsin L-like protease 0.0033 0.0022 0.0829
Schistosoma mansoni hypothetical protein 0.0022 0.001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0041 0.003 0.003
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0073 0.0064 0.0205
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0006 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0069 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0011 0.0083
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.0064 0.0765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Echinococcus granulosus ferritin 0.0018 0.0006 0.0006
Echinococcus granulosus cysteine protease 0.0017 0.0005 0.0005
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0019 0.0695
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.012 1
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.0068 0.561
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0253 0.0252 0.0866
Schistosoma mansoni hypothetical protein 0.031 0.0312 0.0308
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0019 0.0594
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0073 0.0064 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Trypanosoma brucei transcription factor BTF3, putative 0.0026 0.0015 0.0941
Echinococcus granulosus replication factor c subunit 1 0.0017 0.0005 0.0005
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0019 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Toxoplasma gondii thioredoxin reductase 0.0077 0.0068 0.258
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Loa Loa (eye worm) beta-lactamase 0.0078 0.0069 0.0436
Schistosoma mansoni hypothetical protein 0.0041 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0249 0.0248 0.1563
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0006 0.0022
Plasmodium vivax thioredoxin reductase, putative 0.0077 0.0068 0.258
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0022 0.0469
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0008 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.012 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0249 0.0248 0.085
Schistosoma mansoni ferritin 0.0018 0.0006 0.0002
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0069 0.0224
Brugia malayi Pre-SET motif family protein 0.0667 0.0687 0.4326
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0005 0.0289
Echinococcus multilocularis thioredoxin glutathione reductase 0.0078 0.0069 0.0068
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0073 0.0064 0.0201
Loa Loa (eye worm) pigment dispersing factor receptor c 0.013 0.0123 0.0778
Echinococcus multilocularis cysteine protease 0.0033 0.0022 0.0022
Brugia malayi PHD-finger family protein 0.0022 0.001 0.0054
Echinococcus granulosus flap endonuclease 1 0.003 0.0019 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0249 0.0248 0.6337
Plasmodium falciparum glutathione reductase 0.0027 0.0015 0.045
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0064 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0033
Trypanosoma brucei trypanothione reductase 0.0077 0.0068 0.552
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0022 0.0218
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0022 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0035 0.0221
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0069 0.022
Leishmania major cathepsin L-like protease 0.0033 0.0022 0.0829
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.001 0.0254
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0015 0.1144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Onchocerca volvulus 0.0078 0.0069 0.0821
Loa Loa (eye worm) hypothetical protein 0.0073 0.0064 0.0402
Onchocerca volvulus Huntingtin homolog 0.0106 0.0099 0.1201
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0022 0.0829
Brugia malayi CHE-14 protein 0.0082 0.0073 0.0449
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0079 0.3
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0019 0.127
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0015 0.0551
Loa Loa (eye worm) oxidoreductase 0.0073 0.0064 0.0402
Entamoeba histolytica hypothetical protein 0.0383 0.0389 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0253 0.0252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Mycobacterium tuberculosis Probable dehydrogenase 0.0176 0.0172 0.058
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0017 0.0005 0.0091
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0249 0.0248 0.085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0033
Echinococcus granulosus importin subunit beta 1 0.0022 0.001 0.001
Brugia malayi hypothetical protein 0.0383 0.0389 0.2443
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0196 0.0192 0.0652
Loa Loa (eye worm) hypothetical protein 0.0186 0.0182 0.1148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0069 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0171 0.0578
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0064 0.5239
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.0551
Leishmania major 4-coumarate:coa ligase-like protein 0.0249 0.0248 1
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0069 0.5602
Loa Loa (eye worm) hypothetical protein 0.0073 0.0064 0.0402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.0064 0.0391
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0005 0.0294
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0019 0.0189
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0064 0.0402
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0253 0.0252 1
Mycobacterium ulcerans lipase LipD 0.0078 0.0069 0.0224
Brugia malayi Importin beta-1 subunit 0.0022 0.001 0.0052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0004 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Loa Loa (eye worm) ctsf protein 0.0033 0.0022 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0022 0.0231
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0006 0.004
Schistosoma mansoni hypothetical protein 0.0041 0.003 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Schistosoma mansoni ferritin 0.0018 0.0006 0.0002
Trichomonas vaginalis glutaminase, putative 0.0207 0.0204 0.2569
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0005 0.0294
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0022 0.0726
Schistosoma mansoni ferritin light chain 0.0018 0.0006 0.0002
Toxoplasma gondii ATPase, AAA family protein 0.0017 0.0005 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0171 0.0578
Plasmodium vivax unspecified product 0.0017 0.0005 0.0045
Leishmania major cathepsin L-like protease 0.0033 0.0022 0.0829
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.0064 0.5239
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0022 0.0218
Loa Loa (eye worm) hypothetical protein 0.0082 0.0073 0.0461
Schistosoma mansoni glutaminase 0.0207 0.0204 0.02
Onchocerca volvulus 0.042 0.0427 0.5427
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0029
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0006 0.0004
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0073 0.0064 0.1551
Echinococcus multilocularis peregrin 0.0022 0.001 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.012 1
Leishmania major cathepsin L-like protease 0.0033 0.0022 0.0829
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.001 0.0521
Brugia malayi MH2 domain containing protein 0.0104 0.0096 0.0593
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0015 0.045
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0106 0.0099 0.0623
Plasmodium vivax vivapain-3 0.0017 0.0005 0.0045
Brugia malayi hypothetical protein 0.0106 0.0099 0.0611
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0383 0.0389 0.0388
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0022 0.0726
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0011 0.0006
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0073 0.0064 0.0205
Schistosoma mansoni importin beta-1 0.0022 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0186 0.0182 0.1148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Brugia malayi Thioredoxin reductase 0.0077 0.0068 0.0418
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0072 0.0063 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0088 0.0088
Onchocerca volvulus 0.0022 0.001 0.0063
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0079 0.0257
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0069 0.0224
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0064 0.0391
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.0069 0.0436
Schistosoma mansoni topbp1 0.0017 0.0005 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0022 0.001 0.0006
Echinococcus granulosus cathepsin l1 0.0022 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0078 0.0069 0.0436
Plasmodium falciparum flap endonuclease 1 0.003 0.0019 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0005 0.0013
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0176 0.0172 0.058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.1144
Echinococcus multilocularis protein patched 0.0082 0.0073 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0073 0.0064 0.0201
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0005 0.0001
Onchocerca volvulus 0.0078 0.0069 0.0821
Loa Loa (eye worm) glutathione reductase 0.0077 0.0068 0.043
Schistosoma mansoni topbp1 0.0017 0.0005 0.0001
Echinococcus granulosus lamin 0.0026 0.0015 0.0014
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2739 0.2858 1
Mycobacterium tuberculosis Conserved protein 0.0078 0.0069 0.022
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0015 0.041
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0029
Loa Loa (eye worm) hypothetical protein 0.042 0.0427 0.2697
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0005 0.0294
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Echinococcus multilocularis lysine specific demethylase 5A 0.0027 0.0015 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0249 0.0248 0.6337
Loa Loa (eye worm) hypothetical protein 0.0089 0.008 0.0506
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0022 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0005 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0011 0.0055
Echinococcus multilocularis microtubule associated protein 2 0.9555 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0011 0.0083
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0006 0.1511
Echinococcus granulosus Niemann Pick C1 protein 0.0273 0.0273 0.0272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0015 0.045
Echinococcus granulosus geminin 0.071 0.0731 0.0731
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0073 0.0064 0.0201
Loa Loa (eye worm) hypothetical protein 0.0186 0.0182 0.1148
Trichomonas vaginalis esterase, putative 0.0078 0.0069 0.0834
Mycobacterium ulcerans acetyl-CoA synthetase 0.0073 0.0064 0.0205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Echinococcus granulosus thioredoxin glutathione reductase 0.0078 0.0069 0.0068
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0004 0.0004
Echinococcus granulosus snurportin 1 0.0233 0.0232 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0005 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0804 0.083 0.083
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2739 0.2858 1
Mycobacterium ulcerans hypothetical protein 0.0249 0.0248 0.085
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0019 0.0119
Loa Loa (eye worm) hypothetical protein 0.01 0.0092 0.0583
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0249 0.0248 0.085
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0064
Schistosoma mansoni hypothetical protein 0.0311 0.0313 0.0309
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0069 0.0424
Loa Loa (eye worm) hypothetical protein 0.0078 0.0069 0.0436
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0064 0.0205
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0015 0.0084
Echinococcus multilocularis protein dispatched 1 0.0093 0.0085 0.0085
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0064 0.5142
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0176 0.0172 0.058
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Plasmodium falciparum importin beta, putative 0.0022 0.001 0.0244
Schistosoma mansoni acetyl-CoA synthetase 0.0073 0.0064 0.006
Loa Loa (eye worm) hypothetical protein 0.0191 0.0187 0.1181
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0383 0.0389 0.0388
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0166 0.0161 0.0546
Loa Loa (eye worm) cysteine protease 0.0033 0.0022 0.014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0041 0.003 0.0179
Echinococcus granulosus lysine specific demethylase 5A 0.0028 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0106 0.0099 0.0623
Mycobacterium ulcerans beta-lactamase 0.0078 0.0069 0.0224
Plasmodium vivax acyl-CoA synthetase, putative 0.0186 0.0182 0.7165
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0249 0.0248 0.1553
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0311 0.0313 0.1966
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0069 0.0834
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0069 0.022
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0073 0.0064 0.0391
Leishmania major cathepsin L-like protease 0.0127 0.012 0.4811
Echinococcus multilocularis Niemann Pick C1 protein 0.0191 0.0187 0.0187
Echinococcus granulosus neuropeptide s receptor 0.0804 0.083 0.083
Plasmodium falciparum glutathione reductase 0.0077 0.0068 0.258
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.0551
Brugia malayi beta-NAC-like protein 0.0026 0.0015 0.0083
Echinococcus multilocularis neuropeptide s receptor 0.0804 0.083 0.083
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0019 0.0594
Plasmodium vivax vivapain-1 0.0017 0.0005 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.031 0.0312 0.0311
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0069 0.0834
Echinococcus multilocularis expressed conserved protein 0.0179 0.0175 0.0175
Toxoplasma gondii HEAT repeat-containing protein 0.0022 0.001 0.0244
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0196 0.0192 0.0656
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.0064 0.252
Trypanosoma cruzi importin beta-1 subunit, putative 0.0018 0.0006 0.0345
Onchocerca volvulus 0.0073 0.0064 0.0753
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0029
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0053 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0029 0.0025
Mycobacterium leprae Probable lipase LipE 0.0078 0.0069 0.0224
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0073 0.0064 0.0201
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0006 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0249 0.0248 0.1553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0015 0.1144
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0022 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0029 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0005 0.0013
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 1
Schistosoma mansoni microtubule-associated protein tau 0.9555 1 1
Onchocerca volvulus 0.0033 0.0022 0.0218
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0294
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0017 0.0005 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0022 0.0726
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0064 0.5239
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0015 0.0092
Entamoeba histolytica hypothetical protein 0.0017 0.0005 0.0027
Toxoplasma gondii ABC1 family protein 0.0078 0.0069 0.2618
Plasmodium vivax SET domain protein, putative 0.0096 0.0088 0.3382
Schistosoma mansoni hypothetical protein 0.0041 0.003 0.0026
Brugia malayi hypothetical protein 0.1524 0.1585 1
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0069 0.022
Leishmania major 4-coumarate:coa ligase-like protein 0.0249 0.0248 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0233 0.0232 0.1462
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0186 0.0182 0.0619
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0171 0.0578
Schistosoma mansoni ferritin 0.0018 0.0006 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0069 0.2618
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0015 0.041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0015 0.0551
Schistosoma mansoni transcription factor LCR-F1 0.0383 0.0389 0.0385
Onchocerca volvulus 0.0033 0.0022 0.0218
Plasmodium vivax acetyl-CoA synthetase, putative 0.0073 0.0064 0.2403
Echinococcus granulosus dnaJ subfamily B 0.031 0.0312 0.0311
Brugia malayi CXXC zinc finger family protein 0.0022 0.001 0.0051
Leishmania major cathepsin L-like protease 0.0033 0.0022 0.0829
Trichomonas vaginalis ferritin, putative 0.0018 0.0006 0.0028
Echinococcus multilocularis nibrin 0.0017 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Echinococcus multilocularis ferritin 0.0018 0.0006 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0006 0.0187
Echinococcus multilocularis lamin dm0 0.0026 0.0015 0.0014
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0004 0.0004
Schistosoma mansoni transcription factor btf3 0.0026 0.0015 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0004 0.0000069273
Plasmodium falciparum phd finger protein, putative 0.0022 0.001 0.0254
Toxoplasma gondii NAC domain-containing protein 0.0026 0.0015 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0005 0.0013
Onchocerca volvulus 0.0022 0.0011 0.007
Echinococcus granulosus cpg binding protein 0.0023 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0079 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0067
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0015 0.008
Loa Loa (eye worm) hypothetical protein 0.0078 0.0069 0.0436
Echinococcus multilocularis musashi 0.0026 0.0015 0.0014
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.0064 0.0765
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0022 0.0231
Plasmodium vivax hypothetical protein, conserved 0.0022 0.001 0.0254
Toxoplasma gondii cathepsin CPL 0.0033 0.0022 0.0726
Echinococcus granulosus GPCR family 2 0.0041 0.003 0.003
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0005 0.0005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0072 0.0063 0.0063
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0073 0.0064 0.0201
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0073 0.0064 0.0201
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0022 0.014
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0073 0.0064 0.0205
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0196 0.0192 0.0652
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0022 0.0469
Echinococcus multilocularis GPCR, family 2 0.0041 0.003 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 0.0866
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0015 0.045
Echinococcus granulosus cathepsin L 0.0017 0.0005 0.0005
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.001 0.0066
Onchocerca volvulus 0.0096 0.0088 0.1065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0667 0.0687 0.4333
Echinococcus multilocularis jumonji domain containing protein 0.0031 0.002 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0249 0.0248 0.085
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0064 0.0201
Plasmodium falciparum acyl-CoA synthetase 0.0186 0.0182 0.7165
Echinococcus multilocularis geminin 0.071 0.0731 0.0731
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0039 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0041 0.003 0.0191
Echinococcus multilocularis expressed protein 0.0018 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0022 0.001 0.0006
Entamoeba histolytica hypothetical protein 0.0026 0.0015 0.0284
Brugia malayi Cathepsin L-like precursor 0.0033 0.0022 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0176 0.0172 0.0584
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0069 0.0436
Echinococcus granulosus tumor protein p63 0.287 0.2995 0.2994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0015 0.1144
Brugia malayi Cathepsin L-like precursor 0.0022 0.0011 0.0055
Mycobacterium ulcerans TetR family transcriptional regulator 0.2739 0.2858 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0017 0.0005 0.0013
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0022 0.0022
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0005 0.0045
Brugia malayi Cathepsin L-like precursor 0.0033 0.0022 0.0128
Entamoeba histolytica hypothetical protein 0.0383 0.0389 1
Echinococcus multilocularis cathepsin L 0.0017 0.0005 0.0005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0015 0.0011
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0006 0.0004
Onchocerca volvulus 0.0033 0.0022 0.0218
Toxoplasma gondii exonuclease III APE 0.0018 0.0006 0.009
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0253 0.0252 0.0252
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0073 0.0064 0.5142
Loa Loa (eye worm) hypothetical protein 0.0186 0.0182 0.1148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0041 0.003 0.003
Schistosoma mansoni peptidase Clp (S14 family) 0.0253 0.0252 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0029 0.0025
Plasmodium falciparum thioredoxin reductase 0.0077 0.0068 0.258
Brugia malayi cathepsin L-like precursor 0.0022 0.0011 0.0055
Schistosoma mansoni cellular tumor antigen P53 0.042 0.0427 0.0423
Brugia malayi DKFZp564C0469 protein 0.0017 0.0005 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0015 0.0964
Brugia malayi Bromodomain containing protein 0.0022 0.001 0.0054
Echinococcus granulosus cathepsin l1 0.0033 0.0022 0.0022
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0069 0.0065
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0006 0.0388
Leishmania major cathepsin L-like protease 0.0127 0.012 0.4811
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0082 0.0073 0.0073
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0015 0.0964
Toxoplasma gondii propionate-CoA ligase 0.0073 0.0064 0.2403
Mycobacterium tuberculosis Conserved protein 0.0078 0.0069 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.0109 0.9026
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0019 0.1445
Onchocerca volvulus 0.0033 0.0022 0.0218
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0249 0.0248 0.085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0033
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0017 0.0005 0.0021
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0017 0.0005 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0804 0.083 0.083
Schistosoma mansoni flap endonuclease-1 0.0027 0.0016 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0069 0.0834
Trypanosoma cruzi transcription factor btf3, putative 0.0026 0.0015 0.1122
Leishmania major basic transcription factor 3a, putative 0.0026 0.0015 0.054
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0064 0.0201
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0064 0.0201
Brugia malayi AMP-binding enzyme family protein 0.0249 0.0248 0.1553
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0005 0.0029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0499 0.051 0.1766
Schistosoma mansoni ferritin light chain 0.0018 0.0006 0.0002
Schistosoma mansoni ferritin 0.0018 0.0006 0.0002
Leishmania major cathepsin L-like protease 0.0127 0.012 0.4811
Plasmodium vivax basic transcription factor 3b, putative 0.0026 0.0015 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0022 0.0231
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0015 0.7588
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0004 0.0026
Echinococcus multilocularis PHD finger protein rhinoceros 0.0022 0.001 0.001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.0084 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0073 0.0064 0.0205
Brugia malayi Pre-SET motif family protein 0.0096 0.0088 0.0544
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0069 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0069 0.569
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Onchocerca volvulus 0.0026 0.0015 0.0121
Loa Loa (eye worm) hypothetical protein 0.0186 0.0182 0.1148
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0073 0.0064 0.0205
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Mycobacterium tuberculosis Probable reductase 0.0176 0.0172 0.058
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0021
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0249 0.0248 0.1563
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0092 0.7598
Plasmodium vivax replication factor C subunit 1, putative 0.0017 0.0005 0.0042
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0191 0.0187 0.476
Echinococcus multilocularis importin subunit beta 1 0.0022 0.001 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0077 0.0068 0.0217
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0006 0.0006
Brugia malayi RNA, U transporter 1 0.0062 0.0052 0.0319
Echinococcus multilocularis survival motor neuron protein 1 0.1524 0.1585 0.1584
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0073 0.0064 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0041 0.003 0.003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0249 0.0248 0.0847
Entamoeba histolytica acyl-coA synthetase, putative 0.0249 0.0248 0.6337
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.0249 0.0248 0.085
Schistosoma mansoni hypothetical protein 0.071 0.0731 0.0727
Onchocerca volvulus 0.0311 0.0313 0.3958
Onchocerca volvulus 0.0249 0.0248 0.3117
Echinococcus granulosus expressed conserved protein 0.0179 0.0175 0.0175
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0082 0.0073 0.0461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0029 0.017
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0073 0.0064 0.0201
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0186 0.0182 0.0616
Brugia malayi beta-lactamase family protein 0.0078 0.0069 0.0424
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0073 0.0064 0.0205
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0017 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0249 0.0248 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.0088 0.0084
Brugia malayi Cathepsin L-like precursor 0.0033 0.0022 0.0128
Echinococcus granulosus jumonji domain containing protein 0.0031 0.002 0.0019
Echinococcus granulosus intermediate filament protein 0.0026 0.0015 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.0096 0.0605
Onchocerca volvulus Alhambra homolog 0.0022 0.001 0.0067
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0253 0.0252 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0253 0.0252 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.012 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0064 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0015 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0029 0.0028
Brugia malayi Cathepsin L-like precursor 0.0033 0.0022 0.0128
Schistosoma mansoni DNA ligase IV 0.0017 0.0005 0.0001
Schistosoma mansoni intermediate filament proteins 0.0026 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0022 0.014
Echinococcus multilocularis lamin 0.0026 0.0015 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.0096 0.0605
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0022 0.0231
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0069 0.0224
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0022 0.014
Echinococcus granulosus peregrin 0.0022 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0033 0.0022 0.0469
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0249 0.0248 0.085
Brugia malayi Cathepsin L-like precursor 0.0033 0.0022 0.0128
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2739 0.2858 1
Plasmodium vivax glutathione reductase, putative 0.0077 0.0068 0.258
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0015 0.0964
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0089
Brugia malayi hypothetical protein 0.0017 0.0005 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0005 0.0289
Entamoeba histolytica transcription factor BTF3, putative 0.0026 0.0015 0.0284
Schistosoma mansoni cpg binding protein 0.0023 0.0011 0.0007
Leishmania major GTP-binding protein, putative 0.0016 0.0004 0.0096
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0015 0.045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.013 0.0123 0.0766
Trypanosoma cruzi FHA domain containing protein, putative 0.0017 0.0005 0.0289
Loa Loa (eye worm) hypothetical protein 0.1524 0.1585 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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