Detailed information for compound 651644

Basic information

Technical information
  • TDR Targets ID: 651644
  • Name: 3-(4-methylphenyl)-2-[4-(2-oxochromen-3-yl)-1 ,3-thiazol-2-yl]prop-2-enenitrile
  • MW: 370.424 | Formula: C22H14N2O2S
  • H donors: 0 H acceptors: 3 LogP: 4.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1ccc(cc1)C)c1scc(n1)c1cc2ccccc2oc1=O
  • InChi: 1S/C22H14N2O2S/c1-14-6-8-15(9-7-14)10-17(12-23)21-24-19(13-27-21)18-11-16-4-2-3-5-20(16)26-22(18)25/h2-11,13H,1H3/b17-10+
  • InChiKey: NHXUPBWAORSKDA-LICLKQGHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(4-methylphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(4-methylphenyl)-2-[4-(2-oxochromen-3-yl)thiazol-2-yl]prop-2-enenitrile
  • 3-(4-methylphenyl)-2-[4-(2-oxochromen-3-yl)thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(4-methylphenyl)-2-[4-(2-oxo-3-chromenyl)-2-thiazolyl]prop-2-enenitrile
  • 3-(4-methylphenyl)-2-[4-(2-oxo-3-chromenyl)-2-thiazolyl]prop-2-enenitrile
  • 2-[4-(2-ketochromen-3-yl)thiazol-2-yl]-3-(4-methylphenyl)acrylonitrile
  • (E)-2-[4-(2-ketochromen-3-yl)thiazol-2-yl]-3-(4-methylphenyl)acrylonitrile
  • ZINC03997873
  • STOCK1S-27073
  • AE-848/36500020

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase kappa 0.0019 0.0009 0.0009
Echinococcus multilocularis expressed protein 0.0018 0.0007 0.0007
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0007 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.007 0.0351
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0009 0.0187
Giardia lamblia DINP protein human, muc B family 0.0019 0.0009 0.2005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0046 0.1627
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.007 0.0827
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0007 0.0435
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0026 0.0909
Echinococcus multilocularis cysteine protease 0.0034 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0064 0.006 0.006
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0058 0.0164
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0026 0.0909
Loa Loa (eye worm) fibroinase 0.0034 0.0026 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Leishmania major cathepsin L-like protease 0.0131 0.0136 0.5026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0187 0.0576
Leishmania major cathepsin L-like protease 0.0131 0.0136 0.5026
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0187 0.0187
Schistosoma mansoni cellular tumor antigen P53 0.0263 0.0288 0.0288
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0018 0.0018
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0029 0.0029
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0071
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0073 0.007 0.0201
Trypanosoma brucei unspecified product 0.0013 0.0002 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0012 0.006
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0012 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0026 0.0026
Leishmania major cathepsin L-like protease 0.0034 0.0026 0.0926
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0247 0.027 0.0842
Onchocerca volvulus 0.0034 0.0026 0.017
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0007
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0009 0.0009
Loa Loa (eye worm) RNA binding protein 0.0064 0.006 0.0301
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0073 0.007 0.0201
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0026 0.0026
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 1
Schistosoma mansoni microtubule-associated protein tau 0.8747 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0077
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0247 0.027 0.0842
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0018 0.0409
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0012 0.006
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0018 0.0646
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0073 0.007 0.0201
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0026 0.0926
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0113 0.1348
Trichomonas vaginalis set domain proteins, putative 0.0739 0.0833 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0073 0.007 0.1621
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0018 0.4379
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.004 0.004
Schistosoma mansoni acetyl-CoA synthetase 0.0073 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0012 0.006
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0153 0.0153
Brugia malayi Pre-SET motif family protein 0.065 0.073 0.3669
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0073 0.007 0.0201
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0252 0.0275 0.0275
Brugia malayi ecdysteroid receptor 0.0022 0.0012 0.006
Onchocerca volvulus 0.0739 0.0833 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0009 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Schistosoma mansoni hypothetical protein 0.0152 0.0161 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0026 0.013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0029 0.0835
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0046 0.0536
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi beta-lactamase 0.011 0.0113 0.0568
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0073 0.007 0.0201
Brugia malayi Cathepsin L-like precursor 0.0034 0.0026 0.013
Brugia malayi steroid hormone receptor 0.0022 0.0012 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0113 0.8296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 0.0859
Brugia malayi AMP-binding enzyme family protein 0.0247 0.027 0.1356
Schistosoma mansoni DNA polymerase eta 0.0045 0.0038 0.0038
Trichomonas vaginalis esterase, putative 0.011 0.0113 0.1348
Entamoeba histolytica acyl-CoA synthetase, putative 0.0247 0.027 0.6334
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Schistosoma mansoni thyroid hormone receptor 0.0174 0.0186 0.0186
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.065 0.073 0.3669
Echinococcus multilocularis tumor protein p63 0.1797 0.2044 0.2044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0187 0.0576
Plasmodium vivax acyl-CoA synthetase, putative 0.0185 0.0198 0.7197
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0113 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0073 0.007 0.2511
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0073 0.007 0.0201
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0041 0.1448
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.0275 1
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0012 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0046 0.1627
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0093 0.3368
Loa Loa (eye worm) hypothetical protein 0.0146 0.0153 0.0771
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 1
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0113 0.0113
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.8747 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0012 0.006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0185 0.0198 0.0613
Plasmodium vivax SET domain protein, putative 0.0093 0.0093 0.3368
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0025 0.0057
Schistosoma mansoni peptidase Clp (S14 family) 0.0252 0.0275 0.0275
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0026 0.1843
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0001 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.006 0.0301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Schistosoma mansoni hypothetical protein 0.0383 0.0426 0.0426
Toxoplasma gondii cathepsin CPL 0.0034 0.0026 0.0909
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0113 0.0113
Plasmodium vivax vivapain-2 0.0034 0.0026 0.0909
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0073 0.007 0.0201
Loa Loa (eye worm) inositol-1 0.0037 0.0029 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0012 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0131 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.0435
Loa Loa (eye worm) oxidoreductase 0.0073 0.007 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0064 0.006 0.006
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0073 0.007 0.2511
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.0093 0.0093 0.0469
Echinococcus granulosus tumor protein p63 0.1797 0.2044 0.2044
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.007 0.256
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Schistosoma mansoni survival motor neuron protein 0.0357 0.0395 0.0395
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0029 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Loa Loa (eye worm) cysteine protease 0.0034 0.0026 0.013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0065
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0073 0.007 0.0201
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0026 0.0587
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Loa Loa (eye worm) hypothetical protein 0.0185 0.0198 0.0996
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0013 0.0013
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2746 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.007 0.0351
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0007 0.0215
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0009 0.0096
Loa Loa (eye worm) hypothetical protein 0.011 0.0113 0.0568
Echinococcus granulosus survival motor neuron protein 1 0.175 0.199 0.199
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0009 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0012 0.006
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0009 0.0589
Mycobacterium ulcerans hypothetical protein 0.011 0.0113 0.034
Echinococcus granulosus ferritin 0.0018 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.027 0.0842
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0113 0.1348
Loa Loa (eye worm) hypothetical protein 0.0247 0.027 0.1356
Schistosoma mansoni inositol monophosphatase 0.0037 0.0029 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0009 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0113 0.034
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0009 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0009 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0113 0.034
Onchocerca volvulus 0.0034 0.0026 0.017
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0025 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Brugia malayi AMP-binding enzyme family protein 0.0247 0.027 0.1356
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0026 0.0299
Echinococcus multilocularis survival motor neuron protein 1 0.175 0.199 0.199
Schistosoma mansoni tar DNA-binding protein 0.0064 0.006 0.006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0185 0.0198 0.0613
Entamoeba histolytica hypothetical protein 0.0383 0.0426 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.027 0.0842
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.004 0.004
Leishmania major cathepsin L-like protease 0.0131 0.0136 0.5026
Toxoplasma gondii hypothetical protein 0.0087 0.0086 0.3103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0029 0.034
Plasmodium falciparum acyl-CoA synthetase 0.0185 0.0198 0.7197
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 0.0859
Loa Loa (eye worm) acetyltransferase 0.0175 0.0187 0.094
Plasmodium vivax hypothetical protein, conserved 0.011 0.0113 0.4091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0013 0.0143
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0113 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Toxoplasma gondii propionate-CoA ligase 0.0073 0.007 0.2511
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.004 0.004
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0093 0.0093 0.0093
Leishmania major hypothetical protein, conserved 0.011 0.0113 0.417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.004 0.02
Loa Loa (eye worm) hypothetical protein 0.0093 0.0093 0.0469
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0073 0.007 0.0201
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0073 0.007 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Schistosoma mansoni hypothetical protein 0.0037 0.0029 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0136 1
Echinococcus granulosus dna polymerase eta 0.0045 0.0038 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Brugia malayi Muscleblind-like protein 0.0146 0.0153 0.0771
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0077
Loa Loa (eye worm) hypothetical protein 0.0185 0.0198 0.0996
Mycobacterium tuberculosis Conserved protein 0.011 0.0113 0.034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0012 0.0012
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0009 0.0296
Loa Loa (eye worm) hypothetical protein 0.0073 0.007 0.0351
Leishmania major DNA polymerase kappa, putative 0.0019 0.0009 0.0296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0706 0.0795 0.2522
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0247 0.027 0.0842
Schistosoma mansoni transcription factor LCR-F1 0.0383 0.0426 0.0426
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0048 0.0242
Loa Loa (eye worm) hypothetical protein 0.0054 0.0048 0.0242
Loa Loa (eye worm) hypothetical protein 0.011 0.0113 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0012 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Plasmodium vivax acetyl-CoA synthetase, putative 0.0073 0.007 0.2511
Schistosoma mansoni hypothetical protein 0.0357 0.0395 0.0395
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.027 1
Leishmania major cathepsin L-like protease 0.0034 0.0026 0.0926
Brugia malayi nuclear hormone receptor 0.0022 0.0012 0.006
Plasmodium vivax unspecified product 0.0018 0.0007 0.0215
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0065
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0086 0.0253
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0029 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.007 0.0201
Loa Loa (eye worm) beta-lactamase 0.011 0.0113 0.0568
Brugia malayi Flap endonuclease-1 0.0028 0.0018 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0012 0.006
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0187 0.0187
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.007 0.256
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0113 0.034
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0026 0.013
Brugia malayi MH2 domain containing protein 0.0126 0.0131 0.0659
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2746 0.3131 1
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0007 0.0007
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.007 0.0201
Mycobacterium ulcerans transcriptional regulator 0.2746 0.3131 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0012 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0012
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0013 0.0065
Onchocerca volvulus 0.0263 0.0288 0.336
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0012 0.0012
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0018 0.0092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0247 0.027 0.6334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0029 0.0029
Brugia malayi Cathepsin L-like precursor 0.0034 0.0026 0.013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0006 0.0031
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0018 0.1286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0034 0.0026 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0247 0.027 0.0842
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.004 0.004
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0165 0.0176 0.054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0247 0.027 0.1356
Echinococcus multilocularis muscleblind protein 0.0146 0.0153 0.0153
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0048 0.0242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0383 0.0426 0.0426
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0113 0.034
Brugia malayi hypothetical protein 0.0383 0.0426 0.2138
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) ctsf protein 0.0034 0.0026 0.013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Onchocerca volvulus 0.0023 0.0013 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0038 0.2765
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0012 0.006
Echinococcus granulosus cathepsin L 0.0018 0.0007 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0012 0.0012
Echinococcus granulosus expressed protein 0.0018 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0174 0.0186 0.0186
Schistosoma mansoni flap endonuclease-1 0.0025 0.0015 0.0015
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0187 0.0576
Plasmodium vivax vivapain-2 0.0034 0.0026 0.0909
Onchocerca volvulus 0.0073 0.007 0.0705
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0029 0.2096
Brugia malayi AMP-binding enzyme family protein 0.0073 0.007 0.0351
Echinococcus multilocularis dna polymerase eta 0.0045 0.0038 0.0038
Brugia malayi RNA binding protein 0.0064 0.006 0.0301
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 1
Brugia malayi Probable ClpP-like protease 0.0252 0.0275 0.1382
Echinococcus multilocularis tar DNA binding protein 0.0064 0.006 0.006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0247 0.027 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0064 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0263 0.0288 0.1446
Onchocerca volvulus 0.0073 0.007 0.0705
Mycobacterium ulcerans TetR family transcriptional regulator 0.2746 0.3131 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0006 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0012 0.0012
Mycobacterium leprae Probable lipase LipE 0.011 0.0113 0.034
Brugia malayi hypothetical protein 0.175 0.199 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0029 0.034
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0018 0.1286
Onchocerca volvulus 0.0247 0.027 0.3142
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0073 0.007 0.5092
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0181 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0012 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0012 0.006
Brugia malayi Inositol-1 0.0037 0.0029 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0012 0.006
Onchocerca volvulus 0.0034 0.0026 0.017
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0012 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.027 0.0842
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0046 0.0046
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0073 0.007 0.0351
Echinococcus granulosus histone lysine methyltransferase setb 0.0093 0.0093 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0045
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0007 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.007 0.0201
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0187 0.094
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0023 0.1628
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2746 0.3131 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Echinococcus multilocularis cathepsin L 0.0018 0.0007 0.0007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0029 0.0072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0113 0.034
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0046 0.1627
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0001 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0009 0.0045
Leishmania major cathepsin L-like protease 0.0034 0.0026 0.0926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0247 0.027 0.1356
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.027 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Echinococcus multilocularis 0.0013 0.0001 0.0001
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0038 0.0193
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0113 0.0568
Trypanosoma brucei unspecified product 0.0013 0.0002 0.0077
Brugia malayi Cathepsin L-like precursor 0.0023 0.0013 0.0065
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0009 0.0006
Mycobacterium leprae conserved hypothetical protein 0.011 0.0113 0.034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Brugia malayi beta-lactamase family protein 0.011 0.0113 0.0568
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0247 0.027 0.0842
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0007 0.0435
Onchocerca volvulus 0.011 0.0113 0.1233
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0034 0.0026 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0012 0.006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0073 0.007 0.0201
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.006
Brugia malayi nuclear receptor NHR-88 0.0022 0.0012 0.006
Loa Loa (eye worm) hypothetical protein 0.011 0.0113 0.0568
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0247 0.027 0.0842
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.007 0.5092
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0006 0.0006
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0073 0.007 0.007
Schistosoma mansoni thyroid hormone receptor 0.0174 0.0186 0.0186
Echinococcus multilocularis cysteine protease 0.0034 0.0026 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0383 0.0426 0.0426
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0113 0.034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0093 0.0093
Echinococcus granulosus cathepsin l1 0.0023 0.0013 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0012 0.0012
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0086 0.3103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0012 0.006
Echinococcus multilocularis peptidase Clp (S14 family) 0.0165 0.0176 0.0176
Mycobacterium tuberculosis Conserved protein 0.011 0.0113 0.034
Trypanosoma brucei unspecified product 0.0019 0.0009 0.0589
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0026 0.0026
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0026 0.0909
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0104 0.7633
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0093 0.0093
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0029 0.1053
Entamoeba histolytica hypothetical protein 0.0383 0.0426 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0012 0.006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0026 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0026 0.013
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0023 0.0803
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0252 0.0275 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0073 0.007 0.0201
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0113 0.0113
Plasmodium vivax vivapain-3 0.0018 0.0007 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0093 0.0093
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0026 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0136 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0131 0.0659
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0009 0.0589
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0001 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Onchocerca volvulus 0.0073 0.007 0.0705
Echinococcus multilocularis ferritin 0.0018 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0007
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0161 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0123 0.904
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.007 0.5092
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0073 0.007 0.0201
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.011 0.0113 0.0568
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.007 0.0351
Echinococcus multilocularis GPCR, family 2 0.0017 0.0006 0.0006
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.007 0.0827
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0031
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0009 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0026 0.0299
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0144
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0048 0.0242
Loa Loa (eye worm) hypothetical protein 0.0146 0.0153 0.0771
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0252 0.0275 0.0275
Leishmania major cathepsin L-like protease 0.0034 0.0026 0.0926
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0187 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0012 0.0012
Loa Loa (eye worm) TAR-binding protein 0.0064 0.006 0.0301
Loa Loa (eye worm) hypothetical protein 0.011 0.0113 0.0568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.004 0.004
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0012 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0357 0.0395 0.1986
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0018 0.0209
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0113 0.8296
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0113 0.8296
Onchocerca volvulus 0.0093 0.0093 0.0991
Leishmania major cathepsin L-like protease 0.0034 0.0026 0.0926
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0007
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0073 0.007 0.0201
Entamoeba histolytica cysteine protease, putative 0.0034 0.0026 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.0435
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0113 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0029 0.2096
Echinococcus granulosus flap endonuclease 1 0.0028 0.0018 0.0018
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0073 0.007 0.0351
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.007 0.5092
Loa Loa (eye worm) hypothetical protein 0.0045 0.0038 0.0193
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0034 0.0026 0.017
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0026 0.017
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0029 0.1033
Onchocerca volvulus 0.0034 0.0026 0.017
Brugia malayi Cathepsin L-like precursor 0.0034 0.0026 0.013
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0018 0.0634
Echinococcus granulosus peptidase Clp S14 family 0.0165 0.0176 0.0176
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0086 0.295
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0165 0.0176 0.054
Trypanosoma cruzi cruzipain precursor, putative 0.0131 0.0136 1
Leishmania major DNA polymerase eta, putative 0.0032 0.0023 0.0818
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0018 0.0634
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0001 0.0001
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0046 0.0536
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0007 0.0435
Brugia malayi Cathepsin L-like precursor 0.0023 0.0013 0.0065
Loa Loa (eye worm) hypothetical protein 0.011 0.0113 0.0568
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0035
Mycobacterium ulcerans beta-lactamase 0.011 0.0113 0.034
Onchocerca volvulus 0.0357 0.0395 0.467
Loa Loa (eye worm) hypothetical protein 0.0185 0.0198 0.0996
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0012 0.006
Schistosoma mansoni tar DNA-binding protein 0.0064 0.006 0.006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.0275 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.027 1
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0136 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.0275 1
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0007 0.0139
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0165 0.0176 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0136 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0073 0.007 0.0201
Echinococcus granulosus cathepsin l1 0.0034 0.0026 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0026 0.0587
Loa Loa (eye worm) hypothetical protein 0.0185 0.0198 0.0996
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.004 0.004
Schistosoma mansoni coup transcription factor 0.0022 0.0012 0.0012
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0041 0.0935
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0073 0.007 0.0201
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0041 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.007 0.0201
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0012 0.006
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0029 0.0667
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0247 0.027 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0012 0.006
Brugia malayi Cathepsin L-like precursor 0.0034 0.0026 0.013
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.004 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.007 0.0201
Plasmodium falciparum flap endonuclease 1 0.0028 0.0018 0.0634
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.007 0.0351
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0086 0.3103
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0029 0.2096
Mycobacterium ulcerans lipase LipD 0.011 0.0113 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0013 0.0143
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0093 0.0093
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Mycobacterium ulcerans acetyl-CoA synthetase 0.0073 0.007 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0012 0.006
Plasmodium vivax vivapain-1 0.0018 0.0007 0.0215
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0012 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Loa Loa (eye worm) hypothetical protein 0.0185 0.0198 0.0996
Brugia malayi AMP-binding enzyme family protein 0.0073 0.007 0.0351
Mycobacterium tuberculosis Conserved protein 0.011 0.0113 0.034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Echinococcus granulosus tar DNA binding protein 0.0064 0.006 0.006
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0073 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0383 0.0426 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0012 0.0012
Entamoeba histolytica acyl-coA synthetase, putative 0.0247 0.027 0.6334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0113 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0012 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0029 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0252 0.0275 0.1382
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0113 0.1348
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0073 0.007 0.256
Brugia malayi beta-lactamase family protein 0.011 0.0113 0.0568
Loa Loa (eye worm) hypothetical protein 0.0247 0.027 0.1356
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0012 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0026 0.017
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0073 0.007 0.5092
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0247 0.027 0.0842
Brugia malayi Cathepsin L-like precursor 0.0034 0.0026 0.013
Brugia malayi TAR-binding protein 0.0064 0.006 0.0301
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0073 0.007 0.2511
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0007
Toxoplasma gondii ABC1 family protein 0.011 0.0113 0.4091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.006
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0009 0.0589
Onchocerca volvulus 0.0034 0.0026 0.017
Brugia malayi cathepsin L-like precursor 0.0023 0.0013 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.175 0.199 1
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0113 0.1348
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Loa Loa (eye worm) hypothetical protein 0.0034 0.0026 0.013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.004 0.02
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.007 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0013 0.0281
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0009 0.0009
Trichomonas vaginalis ferritin, putative 0.0018 0.0007 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0012 0.006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0113 0.0568
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.006 0.0301
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.007 0.5092
Entamoeba histolytica hypothetical protein 0.0383 0.0426 1
Echinococcus granulosus cysteine protease 0.0018 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0589
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Echinococcus granulosus muscleblind protein 0.0146 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0006
Onchocerca volvulus 0.0073 0.007 0.0705
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0073 0.007 0.0351
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0113 0.1348
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0006 0.0031
Onchocerca volvulus 0.011 0.0113 0.1233
Onchocerca volvulus 0.011 0.0113 0.1233
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.007 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0026 0.0299
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0026 0.017
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0038 0.2765
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0252 0.0275 0.0859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0026 0.0299
Echinococcus granulosus GPCR family 2 0.0017 0.0006 0.0006
Leishmania major DNA polymerase eta, putative 0.0045 0.0038 0.139
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0007 0.0435

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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