Detailed information for compound 657256

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 443.491 | Formula: C27H25NO5
  • H donors: 1 H acceptors: 3 LogP: 4.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1N(CCc2ccccc2)C(=O)C(=C1C(=O)c1ccc(cc1)OC)O
  • InChi: 1S/C27H25NO5/c1-32-21-12-8-19(9-13-21)24-23(25(29)20-10-14-22(33-2)15-11-20)26(30)27(31)28(24)17-16-18-6-4-3-5-7-18/h3-15,24,30H,16-17H2,1-2H3
  • InChiKey: ALHZBTXOFILISB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0131 0.2887
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Schistosoma mansoni glutamate synthase 0.0025 0.0015 0.0015
Brugia malayi hypothetical protein 0.0017 0 0.0003
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0198 0.0198
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.0056
Brugia malayi Inositol-1 0.0036 0.0035 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0057 0.1329
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0015 0.0015
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0015 0.0092
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0094 0.0138 0.0138
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0078 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.0138 0.5628
Schistosoma mansoni lamin 0.0027 0.0019 0.0019
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0272 0.0454 0.0454
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0018 0.0004 0.0004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0035 0.0094
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0061
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0037 0.0801
Mycobacterium ulcerans hypothetical protein 0.0042 0.0045 0.0121
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0008 0.0175
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0015 0.0335
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0015 0.0567
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0045 0.0121
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0018
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0015 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0227 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.006 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0035 0.021
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0121 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0097 0.0266
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0015 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0065 0.1521
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0015 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0035 0.0808
Loa Loa (eye worm) glutathione reductase 0.0271 0.0452 0.2721
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0009 0.0056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0035 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0094 0.0138 0.3044
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0175
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.0138 0.3028
Giardia lamblia GTOR 0.009 0.0131 0.947
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0015 0.0038
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0015 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0057 0.1329
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0017 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0057 0.1326
Trichomonas vaginalis mercuric reductase, putative 0.0094 0.0138 0.3205
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0198 0.0198
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0035 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0082 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0035 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0035 0.021
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0094 0.0138 0.038
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0018
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0131 0.0131
Mycobacterium ulcerans hypothetical protein 0.0071 0.0097 0.0266
Loa Loa (eye worm) hypothetical protein 0.005 0.0061 0.0364
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0131 0.304
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0025 0.0015 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0035 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0097 0.2148
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0045 0.1047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0035 0.0035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0035 0.021
Schistosoma mansoni inositol monophosphatase 0.0036 0.0035 0.0035
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0033 0.071
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0008 0.0018
Schistosoma mansoni ferritin light chain 0.0017 0.0002 0.0002
Onchocerca volvulus 0.0042 0.0045 0.1047
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0 0.0001
Schistosoma mansoni glutamate synthase 0.0025 0.0015 0.0015
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0393
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0045 0.0994
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0035 0.0035
Schistosoma mansoni peptidase Clp (S14 family) 0.0153 0.0243 0.0243
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0033 0.0033
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0065 0.1442
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0097 0.303
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0072 0.1598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0066 0.1543
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0097 0.0585
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0017 0.0363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0061 0.0364
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0035 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.0374 0.225
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0153 0.0243 0.0243
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0015 0.0352
Echinococcus granulosus glutamate synthase 0.0025 0.0015 0.0015
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0082 0.1811
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0015 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0198 0.0198
Loa Loa (eye worm) thioredoxin reductase 0.0271 0.0452 0.2721
Brugia malayi Pre-SET motif family protein 0.0227 0.0374 0.225
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0198 0.0198
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0004 0.0023
Entamoeba histolytica hypothetical protein 0.0144 0.0227 0.7083
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0271 0.0452 0.1257
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0015 0.0038
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0198 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0097 0.0585
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0045 0.0121
Schistosoma mansoni hypothetical protein 0.0173 0.0278 0.0278
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0015 0.0352
Schistosoma mansoni hypothetical protein 0.0081 0.0116 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0015 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0008 0.0008
Echinococcus multilocularis protein dispatched 1 0.0096 0.0142 0.0142
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0015 0.0335
Echinococcus granulosus expressed protein 0.0017 0.0002 0.0002
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0001 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0035 0.0035
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0064 0.0386
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0035 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0258 0.0429 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0025 0.0568
Echinococcus granulosus peptidase Clp S14 family 0.0101 0.015 0.015
Leishmania major cathepsin L-like protease 0.0062 0.0082 0.1811
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0004 0.0084
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.032 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0035 0.0035
Schistosoma mansoni glutamate synthase 0.0025 0.0015 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0035 0.0035
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0008 0.0018
Brugia malayi Papain family cysteine protease containing protein 0.0016 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0097 0.0267
Echinococcus granulosus Niemann Pick C1 protein 0.0281 0.047 0.047
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0008 0.0018
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0008 0.0018
Schistosoma mansoni hypothetical protein 0.0173 0.0278 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0035 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0164 0.099
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0017 0.0341
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0035 0.0035
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0015 0.0015
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0153 0.0243 0.1466
Onchocerca volvulus 0.0071 0.0097 0.2261
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0008 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.0138 0.3028
Brugia malayi jmjC domain containing protein 0.0035 0.0033 0.02
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0094 0.0138 0.3044
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0094 0.0138 0.0379
Onchocerca volvulus 0.0042 0.0045 0.1047
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.009 0.1982
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0015 0.0335
Mycobacterium ulcerans lipase LipD 0.0042 0.0045 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0393
Brugia malayi glutathione reductase 0.0271 0.0452 0.2721
Onchocerca volvulus 0.0042 0.0045 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0025
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0027 0.0019 0.0019
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0065 0.1433
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0015 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.0056
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0097 0.0266
Treponema pallidum oxidoreductase 0.0025 0.0015 0.0567
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0618 0.1068 0.2977
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0015 0.0335
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0017 0.0363
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0029 0.0634
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0121 0.0121
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0015 0.0335
Brugia malayi jmjC domain containing protein 0.0131 0.0204 0.1229
Loa Loa (eye worm) hypothetical protein 0.0084 0.0121 0.0728
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0035 0.0035
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0015 0.0038
Schistosoma mansoni hypothetical protein 0.0109 0.0164 0.0164
Loa Loa (eye worm) fibroinase 0.0016 0 0.0001
Onchocerca volvulus 0.0027 0.0019 0.0439
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0035 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0094 0.0138 0.3028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0004 0.0079
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0015 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0049
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0025 0.054
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0035 0.0755
Echinococcus multilocularis expressed protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0057 0.1329
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0008 0.0152
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1621 0.2849 0.2849
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0025 0.0015 0.0335
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0015 0.0472
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0004 0.0004
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0065 0.2192
Brugia malayi nuclear receptor RXR 0.0022 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0045 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0098 0.2279
Brugia malayi Pre-SET motif family protein 0.0033 0.0029 0.0173
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0035 0.1096
Brugia malayi hypothetical protein 0.0144 0.0227 0.1367
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0131 0.287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0035 0.021
Brugia malayi beta-lactamase family protein 0.0042 0.0045 0.0271
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0004 0.0112
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0035 0.0777
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0035 0.0777
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0035 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0035 0.0035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0061 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0033 0.02
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0015 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Echinococcus granulosus survival motor neuron protein 1 0.0952 0.1661 0.1661
Schistosoma mansoni ferritin 0.0017 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.005 0.0061 0.0061
Onchocerca volvulus 0.0036 0.0035 0.0808
Echinococcus multilocularis expressed conserved protein 0.0185 0.0299 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0098 0.2279
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0065 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Plasmodium vivax glutathione reductase, putative 0.0271 0.0452 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0082 0.1811
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.0396 0.2382
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0194 0.0316 0.1901
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Echinococcus multilocularis glutamate synthase 0.0025 0.0015 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0008 0.0185
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0131 0.0131
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2039 0.3591 1
Plasmodium vivax thioredoxin reductase, putative 0.0271 0.0452 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0035 0.0035
Toxoplasma gondii FATC domain-containing protein 0.0017 0.0001 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0019 0.0114
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0033 0.0732
Schistosoma mansoni lamin 0.0027 0.0019 0.0019
Brugia malayi nuclear receptor NHR-88 0.0036 0.0035 0.021
Entamoeba histolytica hypothetical protein 0.0144 0.0227 0.7083
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0025 0.0518
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0015 0.0038
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0035 0.1393
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 0.0674
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0098 0.2167
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0045 0.1047
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0004 0.0079
Echinococcus multilocularis GPCR, family 2 0.005 0.0061 0.0061
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0035 0.021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0027 0.0027
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0187 0.4125
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0056
Brugia malayi jmjC domain containing protein 0.0035 0.0033 0.02
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0015 0.0038
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0015 0.0472
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0015 0.0015
Onchocerca volvulus 0.0021 0.0008 0.0185
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0094 0.0138 0.5365
Echinococcus multilocularis ferritin 0.0017 0.0002 0.0002
Onchocerca volvulus 0.0194 0.0316 0.7354
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0045 0.0973
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0008 0.0018
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.032 0.032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0326 0.0326
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0015 0.0352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0131 0.0786
Brugia malayi RNA binding protein 0.0128 0.0198 0.1191
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0056
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0015 0.0335
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0008 0.0049
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0131 0.0204 0.0204
Schistosoma mansoni ferritin 0.0017 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0053 0.0065 0.1433
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0033 0.0033
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0015 0.0335
Loa Loa (eye worm) hypothetical protein 0.0109 0.0164 0.099
Echinococcus multilocularis lamin 0.0027 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0098 0.2279
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0025 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0035 0.021
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0008 0.0018
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0015 0.0335
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2035 0.3584 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.006 0.0164
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0019 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0078 0.1816
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0015 0.0335
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0015 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0009 0.0009
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0025 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0262 0.0262
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0035 0.0033 0.02
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0078 0.1712
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0015 0.0335
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0015 0.0352
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0015 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0131 0.304
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0131 0.2887
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0094 0.0138 0.3044
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0094 0.0138 0.3044
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0015 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.006 0.0164
Giardia lamblia Glutamate synthase 0.0025 0.0015 0.0861
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0035 0.0035
Entamoeba histolytica protein kinase rad3, putative 0.0017 0.0001 0.0033
Mycobacterium tuberculosis Probable reductase 0.0618 0.1068 0.2977
Plasmodium vivax JmjC domain containing protein 0.0035 0.0033 0.0732
Brugia malayi beta-lactamase family protein 0.0042 0.0045 0.0271
Mycobacterium leprae Probable lipase LipE 0.0042 0.0045 0.0121
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0035 0.0808
Entamoeba histolytica hypothetical protein 0.0144 0.0227 0.7083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.0138 0.3044
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0033 0.0033
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0131 0.0131
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0025 0.054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0028
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0004 0.0091
Giardia lamblia Thioredoxin reductase 0.0025 0.0015 0.0861
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0015 0.0472
Toxoplasma gondii ABC1 family protein 0.0042 0.0045 0.0994
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0035 0.021
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0015 0.0472
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0101 0.015 0.0413
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0035 0.0035
Echinococcus multilocularis geminin 0.0173 0.0278 0.0278
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0097 0.2148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0057 0.1329
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0015 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0097 0.0266
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0097 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0121 0.2815
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0015 0.0038
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0008 0.0018
Entamoeba histolytica hypothetical protein 0.0144 0.0227 0.7083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0035 0.021
Mycobacterium tuberculosis Probable dehydrogenase 0.0618 0.1068 0.2977
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0045 0.0121
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.0001 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0035 0.0818
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0029 0.0029
Schistosoma mansoni apoferritin-2 0.0017 0.0002 0.0002
Onchocerca volvulus 0.0028 0.0022 0.0498
Plasmodium falciparum thioredoxin reductase 0.0094 0.0138 0.3044
Loa Loa (eye worm) oxidoreductase 0.0021 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0092
Brugia malayi ecdysteroid receptor 0.0036 0.0035 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0008 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0035 0.021
Schistosoma mansoni inositol monophosphatase 0.0036 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0098 0.2279
Leishmania major hypothetical protein, conserved 0.0035 0.0033 0.0732
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0018
Brugia malayi Thioredoxin reductase 0.0271 0.0452 0.2721
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0025 0.0148
Schistosoma mansoni hypothetical protein 0.0025 0.0015 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0153 0.0243 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0057 0.1326
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0062 0.0082 0.1811
Loa Loa (eye worm) ctsf protein 0.0016 0 0.0001
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0015 0.0015
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0065 0.1433
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.02
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0025 0.0015 0.0038
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0033 0.0033
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0033 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0045 0.1047
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0015 0.0312
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0061
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0015 0.0567
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0131 0.4073
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0004 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0078 0.0212
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.0204 0.1229
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0008 0.0185
Echinococcus granulosus lysine specific demethylase 5A 0.0131 0.0204 0.0204
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0187 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0033 0.02
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0097 0.303
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0069 0.0093 0.0563
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0008 0.0175
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0015 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0187 0.0515
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0033 0.0732
Toxoplasma gondii selenide, water dikinase 0.0025 0.0015 0.0335
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0131 0.2887
Onchocerca volvulus 0.0256 0.0426 0.9912
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0015 0.0038
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0094 0.0138 0.3028
Schistosoma mansoni hypothetical protein 0.0081 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0025 0.0568
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0187 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0035 0.021
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0131 0.2887
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0198 0.1191
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0015 0.0335
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0035 0.021
Brugia malayi CHE-14 protein 0.0084 0.0121 0.0728
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0109
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0015 0.0335
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0061 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0029 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0094 0.0138 0.0138
Loa Loa (eye worm) cysteine protease 0.0016 0 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0025 0.0148
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0094 0.0138 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0045 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0029 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0045 0.1047
Trichomonas vaginalis ferritin, putative 0.0017 0.0002 0.0033
Treponema pallidum thioredoxin reductase (trxB) 0.0025 0.0015 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0035 0.021
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0094 0.0138 0.3044
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0035 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0017 0.0363
Loa Loa (eye worm) hypothetical protein 0.0197 0.032 0.1929
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0101 0.015 0.0413
Schistosoma mansoni hypothetical protein 0.0194 0.0316 0.0316
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0008 0.0175
Echinococcus multilocularis musashi 0.0027 0.0019 0.0019
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0015 0.0015
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0008 0.0018
Plasmodium vivax SET domain protein, putative 0.0033 0.0029 0.0634
Schistosoma mansoni apoferritin-2 0.0017 0.0002 0.0002
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0015 0.0352
Loa Loa (eye worm) hypothetical protein 0.0103 0.0155 0.0932
Brugia malayi hypothetical protein 0.0952 0.1661 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0033 0.0732
Schistosoma mansoni ferritin light chain 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0015 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0045 0.0045
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0035 0.0777
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0015 0.0352
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Loa Loa (eye worm) hypothetical protein 0.0071 0.0097 0.0585
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0008 0.0018
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Onchocerca volvulus 0.0033 0.0029 0.0667
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Brugia malayi hypothetical protein 0.0022 0.0009 0.0056
Mycobacterium ulcerans TetR family transcriptional regulator 0.2039 0.3591 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0035 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0198 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0065 0.1521
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0056
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0015 0.0312
Toxoplasma gondii exonuclease III APE 0.0018 0.0004 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0187 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0025 0.0568
Leishmania major hypothetical protein, conserved 0.0025 0.0015 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0015 0.0312
Schistosoma mansoni jumonji domain containing protein 0.0131 0.0204 0.0204
Brugia malayi Probable ClpP-like protease 0.0153 0.0243 0.1466
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0094 0.0138 0.0829
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0008 0.0049
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0008 0.0248
Toxoplasma gondii NADPH-glutathione reductase 0.0094 0.0138 0.3044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0114
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0175
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0393
Leishmania major hypothetical protein, conserved 0.0025 0.0015 0.0335
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0097 0.0266
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0097 0.0266
Echinococcus granulosus tar DNA binding protein 0.0128 0.0198 0.0198
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0061 0.0364
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0045 0.0121
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0131 0.4073
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0153 0.0243 0.0243
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.0444 0.1235
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0049
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0094 0.0138 0.3044
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0015 0.0472
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0035 0.0818
Plasmodium falciparum glutathione reductase 0.0094 0.0138 0.3044
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0097 0.2148
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0128 0.0198 0.0198
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0065 0.1442
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0159 0.0254 0.1528
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Loa Loa (eye worm) hypothetical protein 0.0952 0.1661 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0045 0.0121
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0618 0.1068 0.2977
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 0.5385
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.0254 0.1528
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0061 0.0061
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0131 0.0786
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0097 0.303
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0008 0.0018
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0101 0.015 0.0413
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0025 0.0015 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0035 0.021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.0243 0.5385
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0094 0.0138 0.0379
Mycobacterium ulcerans beta-lactamase 0.0042 0.0045 0.0121
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0121 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Trypanosoma cruzi trypanothione reductase, putative 0.0271 0.0452 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0015 0.0038
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0008 0.0018
Brugia malayi MH2 domain containing protein 0.0239 0.0396 0.2382
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0008 0.0018
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0008 0.0049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0045 0.0271
Brugia malayi glutamate synthase 0.0025 0.0015 0.0092
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0152
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0035 0.0035
Brugia malayi hypothetical protein 0.0022 0.0009 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0035 0.021
Leishmania major hypothetical protein, conserved 0.0026 0.0017 0.0363
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0262 0.0262
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0281 0.047 0.047
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0078 0.0467
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0015 0.0312
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0078 0.0212
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0025 0.054
Leishmania major hypothetical protein, conserved 0.0025 0.0015 0.0335
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0094 0.0138 0.0379
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0015 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0035 0.0035
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0033 0.0033
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0015 0.0861
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0004 0.0079
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0008 0.0175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0029 0.0029
Echinococcus multilocularis protein patched 0.0084 0.0121 0.0121
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0008 0.0018
Echinococcus granulosus phd:f box containing protein 0.0035 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0025 0.0568
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0687 0.119 0.3319
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0009
Mycobacterium ulcerans dehydrogenase 0.0025 0.0015 0.0038
Mycobacterium tuberculosis Conserved protein 0.0042 0.0045 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0045 0.1047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0035 0.021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0029 0.0075
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0393
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0015 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0004 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0045 0.0121
Trichomonas vaginalis esterase, putative 0.0042 0.0045 0.1047
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.032 0.1929
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0144 0.0227 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0066 0.1543
Echinococcus granulosus geminin 0.0173 0.0278 0.0278
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0035 0.0035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0078 0.0212
Echinococcus multilocularis lysine specific demethylase 5A 0.0131 0.0204 0.0204
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0618 0.1068 0.2977
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0015 0.0038
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0015 0.0352
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0618 0.1068 0.2977
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.0138 0.5628
Trypanosoma brucei trypanothione reductase 0.0271 0.0452 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0035 0.021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0015 0.0352
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0033 0.0033
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0008 0.0049
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0035 0.0808
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0015 0.0472
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.032 0.032
Mycobacterium tuberculosis Conserved protein 0.0042 0.0045 0.0121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0198 0.1191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.006 0.0164
Brugia malayi nuclear hormone receptor 0.0036 0.0035 0.021
Onchocerca volvulus 0.0025 0.0015 0.0352
Onchocerca volvulus 0.0021 0.0008 0.0185
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0015 0.0335
Onchocerca volvulus 0.0021 0.0008 0.0185
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0187 0.4125
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0017 0.0001 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0017 0.0363
Mycobacterium ulcerans transcriptional regulator 0.2039 0.3591 1
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0035 0.0035
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2039 0.3591 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0098 0.2279
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0033 0.0732
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0045 0.0121
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0045 0.0045
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0015 0.0038
Echinococcus granulosus expressed conserved protein 0.0185 0.0299 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0035 0.021
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0015 0.0335
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0004 0.0079
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0029 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0007
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0015 0.0335
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0198 0.1191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0004 0.0004
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.0204 0.0204
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.0243 0.5385
Brugia malayi steroid hormone receptor 0.0036 0.0035 0.021
Leishmania major trypanothione reductase 0.0271 0.0452 1
Onchocerca volvulus 0.0258 0.0429 1
Brugia malayi intermediate filament protein 0.0027 0.0019 0.0114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0061 0.0061
Brugia malayi jmjC domain containing protein 0.0035 0.0033 0.02
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0081 0.0116 0.0116
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0033 0.0033
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0015 0.0038
Echinococcus granulosus ferritin 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0271
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0045 0.0271
Leishmania major cathepsin L-like protease 0.0062 0.0082 0.1811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0008 0.0018
Brugia malayi beta-lactamase 0.0042 0.0045 0.0271
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0015 0.0352
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0045 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0057 0.1326
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0015 0.0015
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0025 0.0518
Echinococcus granulosus lamin dm0 0.0027 0.0019 0.0019
Onchocerca volvulus 0.0027 0.0019 0.0439
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0173
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0008 0.0008
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0008 0.0175
Schistosoma mansoni intermediate filament proteins 0.0027 0.0019 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0029 0.0029
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0098 0.2149
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0025 0.0025
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0078 0.0078
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0001 0.0024
Mycobacterium ulcerans hypothetical protein 0.0025 0.0015 0.0038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0131 0.287
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0019 0.0114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0131 0.0204 0.0204
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Loa Loa (eye worm) RNA binding protein 0.0128 0.0198 0.1191
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0047 0.1005
Leishmania major hypothetical protein, conserved 0.0042 0.0045 0.0994
Leishmania major NADH dehydrogenase, putative 0.0025 0.0015 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0075 0.1735
Brugia malayi Latrophilin receptor protein 2 0.005 0.0061 0.0364
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0008 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0033 0.02
Schistosoma mansoni ferritin 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0687 0.119 0.3319
Brugia malayi jmjC domain containing protein 0.0131 0.0204 0.1229
Schistosoma mansoni cellular tumor antigen P53 0.0256 0.0426 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.009 0.2087
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0008 0.0008
Schistosoma mansoni coup transcription factor 0.0036 0.0035 0.0035
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0687 0.119 0.3319
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0029 0.0029
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0008 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.021
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0015 0.0352
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0015 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0004 0.0079
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0138 0.3044
Loa Loa (eye worm) beta-lactamase 0.0042 0.0045 0.0271
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0098 0.2167
Loa Loa (eye worm) hypothetical protein 0.0071 0.0097 0.0585
Echinococcus multilocularis survival motor neuron protein 1 0.0952 0.1661 0.1661
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0035 0.021
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0015 0.0352
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0025 0.054
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0065 0.2619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0069 0.0093 0.0563
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.0396 0.2382
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0045 0.0045
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0015 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.5649 1 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0015 0.0335
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.0254 0.1528
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0033 0.0732
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0035 0.0818
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0198 0.0198
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0015 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0017 0.0363
Plasmodium falciparum thioredoxin reductase 0.0271 0.0452 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0066 0.1543
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0097 0.0585
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0121 0.0728
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0004 0.0023
Giardia lamblia NADH oxidase lateral transfer candidate 0.0094 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.02
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0078 0.0078
Plasmodium falciparum glutathione reductase 0.0271 0.0452 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.0204 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0045 0.0994
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0187 0.0187
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0058 0.1285
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0035 0.0035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0227 0.0227
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0015 0.0015
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0153 0.0243 0.5385
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0687 0.119 0.3313
Echinococcus granulosus tumor protein p63 0.1749 0.3076 0.3076
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.0243 0.0674
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0025 0.0015 0.0335
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.0138 0.3044
Toxoplasma gondii thioredoxin reductase 0.0271 0.0452 1
Schistosoma mansoni ferritin 0.0017 0.0002 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0262 0.0262
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0094 0.0138 0.3044
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0053 0.0065 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0005 0.0105
Schistosoma mansoni survival motor neuron protein 0.0194 0.0316 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0014 0.0319
Schistosoma mansoni patched 1 0.0084 0.0121 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0097 0.0266
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0004 0.0056
Treponema pallidum NADH oxidase 0.0094 0.0138 0.5628
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0097 0.0266
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0045 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0035 0.021
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0198 0.0198
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0029 0.0075
Trichomonas vaginalis glutathione reductase, putative 0.0094 0.0138 0.3205
Echinococcus multilocularis tumor protein p63 0.1749 0.3076 0.3076
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0005 0.01
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0107 0.2496
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0082 0.1811
Echinococcus granulosus lamin 0.0027 0.0019 0.0019
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0175
Echinococcus granulosus thioredoxin glutathione reductase 0.0272 0.0454 0.0454
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0025 0.0015 0.0567
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0015 0.0015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0004 0.0091
Schistosoma mansoni hypothetical protein 0.005 0.0061 0.0061
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0033 0.0033
Loa Loa (eye worm) inositol-1 0.0036 0.0035 0.0212
Entamoeba histolytica hypothetical protein 0.0017 0.0001 0.0033
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0015 0.0335
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0081 0.0116 0.0116
Brugia malayi hypothetical protein 0.0026 0.0017 0.01
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0008 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0097 0.0266
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0131 0.304
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0097 0.0266
Schistosoma mansoni ap endonuclease 0.0018 0.0004 0.0004
Brugia malayi TAR-binding protein 0.0128 0.0198 0.1191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0082 0.1791
Mycobacterium ulcerans monoxygenase 0.0025 0.0015 0.0038
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0618 0.1068 0.2972
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0033 0.0033
Echinococcus multilocularis peptidase Clp (S14 family) 0.0101 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0271
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0008 0.0175
Loa Loa (eye worm) hypothetical protein 0.0071 0.0097 0.0585
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0271
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0022
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0065 0.0178
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0035 0.0777
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0008 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.5649 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.01
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0033 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.0254 0.1528
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0004 0.0084
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0015 0.0352
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0035 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0138 0.3044
Loa Loa (eye worm) hypothetical protein 0.0256 0.0426 0.2562
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0045 0.0121
Echinococcus multilocularis lamin dm0 0.0027 0.0019 0.0019
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0015 0.0335

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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