Detailed information for compound 657471

Basic information

Technical information
  • TDR Targets ID: 657471
  • Name: 6-chloro-2,3,4,9-tetrahydrocarbazol-1-one
  • MW: 219.667 | Formula: C12H10ClNO
  • H donors: 1 H acceptors: 1 LogP: 3.11 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c1CCCC(=O)c1[nH]2
  • InChi: 1S/C12H10ClNO/c13-7-4-5-10-9(6-7)8-2-1-3-11(15)12(8)14-10/h4-6,14H,1-3H2
  • InChiKey: PUQOGOYIOUCDPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZERO/008680
  • ZINC00097316
  • 6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one
  • MLS000122313
  • SMR000119735
  • Oprea1_632762
  • Oprea1_365572
  • CBMicro_007757
  • 6-Chloro-2,3,4,9-tetrahydro-carbazol-1-one
  • BAS 01261546
  • Carbazol-1(2H)-one, 3,4-dihydro-6-chloro-
  • BIM-0007845.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0033 0.0031 0.1309
Echinococcus multilocularis survival motor neuron protein 1 0.0703 0.1246 0.1244
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.0151 0.643
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0044 0.1492
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.005 0.128
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0017 0.0725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Brugia malayi Importin beta-1 subunit 0.0035 0.0034 0.027
Loa Loa (eye worm) hypothetical protein 0.007 0.0097 0.0783
Echinococcus granulosus intermediate filament protein 0.0033 0.003 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0015 0.0535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Mycobacterium ulcerans beta-lactamase 0.0145 0.0234 0.0433
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2751 0.4958 1
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0001 0.0063
Toxoplasma gondii hypothetical protein 0.0053 0.0067 0.2209
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.014 0.477
Onchocerca volvulus 0.0094 0.014 0.3618
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.002 0.0872
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0001 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.1877
Schistosoma mansoni cellular tumor antigen P53 0.0195 0.0323 0.0322
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0017 0.0725
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0015 0.0535
Onchocerca volvulus 0.0028 0.002 0.0526
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.002 0.0019
Onchocerca volvulus 0.0195 0.0323 0.833
Plasmodium vivax SET domain protein, putative 0.0029 0.0023 0.0874
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.014 0.5998
Leishmania major hypothetical protein, conserved 0.0024 0.0015 0.063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0031 0.0029
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.002 0.0872
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.014 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0094 0.014 0.1127
Plasmodium vivax vivapain-2 0.0033 0.0031 0.1176
Loa Loa (eye worm) hypothetical protein 0.0094 0.014 0.1127
Entamoeba histolytica Ran family GTPase 0.0026 0.0017 0.0577
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.02 0.8525
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.002 0.0526
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0031 0.1176
Mycobacterium tuberculosis Conserved protein 0.0145 0.0234 0.0446
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.005 0.128
Loa Loa (eye worm) hypothetical protein 0.0145 0.0234 0.188
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0234 0.0233
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0144 0.0143
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0017 0.0725
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 1
Onchocerca volvulus 0.0029 0.0023 0.0596
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.002 0.0872
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.002 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0031 0.1309
Onchocerca volvulus 0.0028 0.002 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0011 0.0365
Brugia malayi AMP-binding enzyme family protein 0.0094 0.014 0.1127
Echinococcus granulosus lamin dm0 0.0033 0.003 0.0028
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0154 0.0249 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Leishmania major cathepsin L-like protease 0.0126 0.02 0.8525
Plasmodium falciparum importin beta, putative 0.0035 0.0034 0.1298
Leishmania major cathepsin L-like protease 0.0033 0.0031 0.1309
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0015 0.063
Echinococcus granulosus expressed conserved protein 0.009 0.0134 0.0132
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0036 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0234 0.0446
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0144 0.1159
Echinococcus multilocularis lamin 0.0033 0.003 0.0028
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0044 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0001 0.005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0234 0.188
Entamoeba histolytica cysteine protease, putative 0.0033 0.0031 0.1041
Schistosoma mansoni peptidase Clp (S14 family) 0.0154 0.0249 0.0248
Mycobacterium ulcerans lipase LipD 0.0145 0.0234 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.005 0.2122
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.002 0.0763
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0022 0.0559
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.002 0.0014
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0031 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Brugia malayi Cathepsin L-like precursor 0.0033 0.0031 0.0246
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0044 0.1132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Entamoeba histolytica hypothetical protein 0.0179 0.0294 1
Trichomonas vaginalis esterase, putative 0.0145 0.0234 0.6032
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0234 0.6032
Brugia malayi beta-lactamase family protein 0.0145 0.0234 0.188
Brugia malayi Pre-SET motif family protein 0.0202 0.0337 0.2709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Echinococcus granulosus survival motor neuron protein 1 0.0703 0.1246 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Brugia malayi hypothetical protein 0.0179 0.0294 0.2364
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 1
Onchocerca volvulus 0.0028 0.002 0.0526
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0031 0.0789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Onchocerca volvulus 0.0033 0.0031 0.0789
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Onchocerca volvulus 0.0145 0.0234 0.6032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Mycobacterium ulcerans hypothetical protein 0.0145 0.0234 0.0433
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Toxoplasma gondii propionate-CoA ligase 0.0028 0.002 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0015 0.0535
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0036 0.0032
Onchocerca volvulus 0.0145 0.0234 0.6032
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0017 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.014 0.0243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0091 0.0156
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0001 0.005
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0234 0.9387
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.005 0.128
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.014 0.0257
Schistosoma mansoni inositol monophosphatase 0.004 0.0044 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0031 0.0029
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0017 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0164
Toxoplasma gondii cathepsin CPL 0.0033 0.0031 0.0678
Loa Loa (eye worm) hypothetical protein 0.0033 0.003 0.0237
Leishmania major cathepsin L-like protease 0.0033 0.0031 0.1309
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0219 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.1877
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.0164
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0246
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0097 0.3873
Loa Loa (eye worm) hypothetical protein 0.007 0.0097 0.0783
Brugia malayi AMP-binding enzyme family protein 0.0094 0.014 0.1127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0086
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.002 0.0164
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.014 0.5998
Echinococcus multilocularis peptidase Clp (S14 family) 0.0101 0.0153 0.0152
Brugia malayi cathepsin L-like precursor 0.0022 0.0011 0.0086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0234 0.0446
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0031 0.0789
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0327 0.2627
Echinococcus multilocularis lamin dm0 0.0033 0.003 0.0028
Loa Loa (eye worm) fibroinase 0.0033 0.0031 0.0246
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0044 0.1132
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0327 0.2627
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0234 0.6032
Schistosoma mansoni hypothetical protein 0.0372 0.0644 0.0643
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.014 0.0243
Schistosoma mansoni importin beta-1 0.0035 0.0034 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.005 0.128
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0234 0.6032
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0118
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.005 0.1687
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.014 0.477
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.002 0.0241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0234 0.188
Loa Loa (eye worm) hypothetical protein 0.0096 0.0144 0.1159
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0001 0.0012
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.002 0.0763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0144 0.0143
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0031 0.0789
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.005 0.128
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.005 0.128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Mycobacterium tuberculosis Conserved protein 0.0145 0.0234 0.0446
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0023 0.0022
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0017 0.0625
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0001 0.0063
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0086
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.002 0.0241
Loa Loa (eye worm) hypothetical protein 0.0154 0.0249 0.2002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.014 0.5998
Brugia malayi Probable ClpP-like protease 0.0154 0.0249 0.2002
Loa Loa (eye worm) hypothetical protein 0.0195 0.0323 0.2596
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0147 0.0146
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 0.0464
Loa Loa (eye worm) intermediate filament protein 0.0033 0.003 0.0237
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0031 0.1309
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0086
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.014 0.0243
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0031 0.0029
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0017 0.0136
Plasmodium vivax vivapain-2 0.0033 0.0031 0.1176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0023 0.0022
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0011 0.0086
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 1
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.002 0.0019
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0017 0.0096
Entamoeba histolytica hypothetical protein 0.0179 0.0294 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0001 0.0063
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0045 0.0044
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2751 0.4958 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0017 0.0625
Onchocerca volvulus 0.0022 0.0011 0.0277
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0229
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0045 0.0362
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.002 0.0014
Mycobacterium ulcerans transcriptional regulator 0.2751 0.4958 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0031 0.0246
Echinococcus granulosus tumor protein p63 0.1329 0.2381 0.238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0115 0.018 0.7676
Brugia malayi hypothetical protein 0.0024 0.0015 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0164
Echinococcus granulosus cathepsin l1 0.0033 0.0031 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0031 0.1041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0179 0.0294 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0015 0.063
Brugia malayi Cathepsin L-like precursor 0.0033 0.0031 0.0246
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.002 0.0872
Brugia malayi intermediate filament protein 0.0033 0.003 0.0237
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0034 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0023 0.0022
Schistosoma mansoni lamin 0.0033 0.003 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.014 0.0243
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0097 0.017
Echinococcus granulosus peptidase Clp S14 family 0.0101 0.0153 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.014 0.0243
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0327 0.0326
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.005 0.0048
Brugia malayi MH2 domain containing protein 0.0144 0.0232 0.1862
Schistosoma mansoni hypothetical protein 0.0143 0.0231 0.0229
Loa Loa (eye worm) cysteine protease 0.0033 0.0031 0.0246
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0337 0.2709
Schistosoma mansoni alpha glucosidase 0.0044 0.005 0.0048
Echinococcus granulosus cathepsin l1 0.0022 0.0011 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0234 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0031 0.0029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0644 0.5174
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0234 1
Mycobacterium leprae Probable lipase LipE 0.0145 0.0234 0.0433
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0023 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0034 0.1437
Onchocerca volvulus 0.0028 0.002 0.0526
Schistosoma mansoni lamin 0.0033 0.003 0.0028
Entamoeba histolytica hypothetical protein 0.0179 0.0294 1
Mycobacterium ulcerans TetR family transcriptional regulator 0.2751 0.4958 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.005 0.2122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Brugia malayi Pre-SET motif family protein 0.0029 0.0023 0.0186
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.002 0.0872
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0031 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0234 0.0433
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 0.0464
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0179 0.0294 0.0293
Onchocerca volvulus 0.0033 0.003 0.0762
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.0164
Onchocerca volvulus 0.0033 0.0031 0.0789
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.002 0.0872
Brugia malayi Cathepsin L-like precursor 0.0033 0.0031 0.0246
Schistosoma mansoni hypothetical protein 0.004 0.0042 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.005 0.128
Brugia malayi Cathepsin L-like precursor 0.0033 0.0031 0.0246
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0186
Schistosoma mansoni patched 1 0.0041 0.0045 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.003 0.0237
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0234 0.6032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0021 0.002
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0145 0.0234 0.188
Schistosoma mansoni ran 0.0026 0.0017 0.0015
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.002 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0001 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0022 0.0559
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0234 0.0446
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0017
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.002 0.0872
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0001 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.002 0.0014
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.005 0.1489
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.002 0.0014
Onchocerca volvulus 0.0145 0.0234 0.6032
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0001 0.005
Brugia malayi CHE-14 protein 0.0041 0.0045 0.0362
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0234 0.0446
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0001 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0031 0.0029
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0031 0.1176
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0154 0.0249 0.0248
Trichomonas vaginalis ran, putative 0.0026 0.0017 0.0438
Schistosoma mansoni transcription factor LCR-F1 0.0179 0.0294 0.0293
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0017 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0929 0.1654 0.3319
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0234 0.0233
Schistosoma mansoni survival motor neuron protein 0.0143 0.0231 0.0229
Loa Loa (eye worm) hypothetical protein 0.0094 0.014 0.1127
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0234 0.0446
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.02 0.8525
Onchocerca volvulus 0.0033 0.0031 0.0789
Leishmania major GTP-binding protein, putative 0.0026 0.0017 0.0725
Brugia malayi hypothetical protein 0.0703 0.1246 1
Schistosoma mansoni hypothetical protein 0.004 0.0042 0.0041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.014 0.0243
Onchocerca volvulus 0.0033 0.003 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0045 0.1163
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0023 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0097 0.0156
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0031 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2751 0.4958 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.002 0.0526
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.002 0.0693
Leishmania major hypothetical protein, conserved 0.0145 0.0234 1
Schistosoma mansoni hypothetical protein 0.004 0.0042 0.0041
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.005 0.0399
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0001 0.005
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0017 0.0015
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0067 0.2626
Brugia malayi beta-lactamase family protein 0.0145 0.0234 0.188
Schistosoma mansoni microtubule-associated protein tau 0.5532 1 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.0164
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0031 0.0246
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0034 0.0806
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.0234 0.0433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Loa Loa (eye worm) hypothetical protein 0.0145 0.0234 0.188
Leishmania major cathepsin L-like protease 0.0033 0.0031 0.1309
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.014 0.0243
Onchocerca volvulus 0.0033 0.0031 0.0789
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.002 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0031 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0234 1
Schistosoma mansoni ran 0.0026 0.0017 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0101 0.0153 0.0269
Loa Loa (eye worm) hypothetical protein 0.0703 0.1246 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.0011 0.0086
Brugia malayi Cathepsin L-like precursor 0.0033 0.0031 0.0246
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0234 0.0446
Echinococcus granulosus importin subunit beta 1 0.0035 0.0034 0.0032
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0154 0.0249 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0232 0.1862
Echinococcus multilocularis snurportin 1 0.0372 0.0644 0.0643
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0219 0.0217
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0067 0.2626
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0154 0.0249 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0154 0.0249 0.0248
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Onchocerca volvulus 0.0033 0.0031 0.0789
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.002 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0034 0.1437
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0015 0.063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0091 0.0156
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.005 0.128
Trichomonas vaginalis set domain proteins, putative 0.023 0.0388 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0023 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.014 0.0257
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0234 0.188
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0234 0.0446
Echinococcus granulosus lamin 0.0033 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0094 0.014 0.1127
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0044 0.0042
Loa Loa (eye worm) inositol-1 0.004 0.0044 0.0353
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.005 0.0399
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Schistosoma mansoni hypothetical protein 0.004 0.0042 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0234 0.6032
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Brugia malayi RNA, U transporter 1 0.0099 0.015 0.1205
Loa Loa (eye worm) beta-lactamase 0.0145 0.0234 0.188
Schistosoma mansoni alpha-glucosidase 0.0169 0.0278 0.0276
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0044 0.0048
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0001 0.0038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.002 0.0164
Loa Loa (eye worm) hypothetical protein 0.007 0.0097 0.0783
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0143 0.0231 0.1851
Echinococcus multilocularis expressed conserved protein 0.009 0.0134 0.0132
Entamoeba histolytica cysteine protease, putative 0.0017 0.0001 0.005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0023 0.0022
Schistosoma mansoni inositol monophosphatase 0.004 0.0044 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.014 0.0243
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0031 0.1176
Loa Loa (eye worm) oxidoreductase 0.0028 0.002 0.0164
Onchocerca volvulus 0.0114 0.0177 0.4556
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.002 0.0014
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.002 0.0014
Leishmania major importin beta-1 subunit, putative 0.0028 0.0022 0.0927
Onchocerca volvulus 0.023 0.0388 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0232 0.1862
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0001 0.005
Schistosoma mansoni hypothetical protein 0.0179 0.0294 0.0293
Loa Loa (eye worm) hypothetical protein 0.007 0.0097 0.0783
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0031 0.0789
Brugia malayi Cathepsin L-like precursor 0.0033 0.0031 0.0246
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.005 0.1687
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.1877
Echinococcus multilocularis cysteine protease 0.0033 0.0031 0.0029
Entamoeba histolytica hypothetical protein 0.0179 0.0294 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0091 0.0156
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0097 0.3873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.02 0.8525
Mycobacterium ulcerans hypothetical protein 0.0094 0.014 0.0243
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.002 0.0164
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0022 0.0927
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0234 0.188
Echinococcus multilocularis tumor protein p63 0.1329 0.2381 0.238
Echinococcus granulosus snurportin 1 0.0372 0.0644 0.0643
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0234 0.0233
Mycobacterium tuberculosis Conserved protein 0.0145 0.0234 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0011 0.0277
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.005 0.0048
Toxoplasma gondii ABC1 family protein 0.0145 0.0234 0.9352
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.007 0.0097 0.0783
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.005 0.128
Leishmania major cathepsin L-like protease 0.0033 0.0031 0.1309
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0101 0.0153 0.0283
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.002 0.0014
Brugia malayi Inositol-1 0.004 0.0044 0.0353
Plasmodium vivax importin-beta 2, putative 0.0035 0.0034 0.1298
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0044 0.1132
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.002 0.0014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0144 0.4903
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0001 0.0063
Loa Loa (eye worm) ctsf protein 0.0033 0.0031 0.0246
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.02 0.8525
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0327 0.0326
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0234 0.0433
Onchocerca volvulus 0.0033 0.0031 0.0789
Onchocerca volvulus 0.0143 0.0231 0.5941
Loa Loa (eye worm) hypothetical protein 0.0035 0.0034 0.027
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.005 0.2122
Entamoeba histolytica hypothetical protein 0.0028 0.0022 0.0737
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0023 0.0358
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0154 0.0249 0.0464
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0053 0.0067 0.0093
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.002 0.0872
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0091 0.0156
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.02 0.8525
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0022 0.0559
Leishmania major cathepsin L-like protease 0.0126 0.02 0.8525
Brugia malayi beta-lactamase 0.0145 0.0234 0.188
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0001 0.005
Entamoeba histolytica acyl-coA synthetase, putative 0.0094 0.014 0.477
Echinococcus multilocularis protein patched 0.0041 0.0045 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.5532 1 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.002 0.0872
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0154 0.0249 1
Echinococcus multilocularis cysteine protease 0.0033 0.0031 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0031 0.0789
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0101 0.0153 0.0283
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0327 0.0326
Echinococcus multilocularis musashi 0.0033 0.003 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0011 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0031 0.0789
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.003 0.0237
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0145 0.0234 0.188
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1574 0.2825 0.2824
Schistosoma mansoni alpha-glucosidase 0.0169 0.0278 0.0276
Loa Loa (eye worm) hypothetical protein 0.005 0.0062 0.0497
Onchocerca volvulus 0.0033 0.0031 0.0789
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0234 0.0233
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.1877
Echinococcus multilocularis protein dispatched 1 0.0047 0.0056 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0031 0.1041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0031 0.0789
Schistosoma mansoni intermediate filament proteins 0.0033 0.003 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0001 0.0063
Trypanosoma brucei glucosidase, putative 0.0044 0.005 0.2122
Leishmania major cathepsin L-like protease 0.0126 0.02 0.8525
Brugia malayi Cathepsin L-like precursor 0.0022 0.0011 0.0086

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1778 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 0.1778 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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