Detailed information for compound 659505

Basic information

Technical information
  • TDR Targets ID: 659505
  • Name: 2-[[3-[(2-carboxyphenyl)carbamoyl]benzoyl]ami no]benzoic acid
  • MW: 404.372 | Formula: C22H16N2O6
  • H donors: 4 H acceptors: 6 LogP: 3.75 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)C(=O)Nc1ccccc1C(=O)O)Nc1ccccc1C(=O)O
  • InChi: 1S/C22H16N2O6/c25-19(23-17-10-3-1-8-15(17)21(27)28)13-6-5-7-14(12-13)20(26)24-18-11-4-2-9-16(18)22(29)30/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
  • InChiKey: RBWLNPUCKIHUDH-UHFFFAOYSA-N  


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Synonyms

  • 2-[[[3-[[(2-carboxyphenyl)amino]-oxomethyl]phenyl]-oxomethyl]amino]benzoic acid
  • 2-[[3-[(2-carboxyphenyl)carbamoyl]phenyl]carbonylamino]benzoic acid
  • BAS 00431953
  • CBDivE_006490
  • STK295526
  • Oprea1_414633
  • Oprea1_444419

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2343 0.4854
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0034 0.0344
Brugia malayi beta-lactamase family protein 0.0072 0.0307 0.0301
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0213 0.0442
Schistosoma mansoni pyruvate kinase 0.0021 0.0058 0.0121
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0153 0.0303
Echinococcus multilocularis protein patched 0.0047 0.0185 0.0212
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0097 0.1516
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.0404 0.0837
Loa Loa (eye worm) beta-lactamase 0.0072 0.0307 0.0301
Mycobacterium ulcerans pyruvate kinase 0.004 0.0153 0.2577
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0058 0.0792
Chlamydia trachomatis pyruvate kinase 0.004 0.0153 1
Entamoeba histolytica hypothetical protein 0.0035 0.0128 0.2081
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0145 0.0138
Echinococcus granulosus dna polymerase kappa 0.0039 0.0145 0.03
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.0018
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0034 0.0071
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0034 0.0071
Loa Loa (eye worm) pyruvate kinase 0.004 0.0153 0.0146
Giardia lamblia DINP protein human, muc B family 0.0039 0.0145 0.9404
Leishmania major DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Leishmania major DNA polymerase eta, putative 0.0038 0.0143 0.0127
Schistosoma mansoni hypothetical protein 0.0165 0.0754 0.1562
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0062 0.1562
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0153 0.0303
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0007 0.0014
Onchocerca volvulus 0.0029 0.0097 0.0186
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0016 0.0034 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0097 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0271 0.0264
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0128 0.0147
Brugia malayi Pip kinase protein 1 0.0016 0.0034 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0157 0.015
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.0034 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0084 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.005 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0014
Leishmania major C-8 sterol isomerase-like protein 0.208 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0145 0.4043
Trichomonas vaginalis esterase, putative 0.0072 0.0307 1
Brugia malayi beta-lactamase family protein 0.0072 0.0307 0.0301
Entamoeba histolytica hypothetical protein 0.0035 0.0128 0.2081
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Onchocerca volvulus 0.0072 0.0307 0.0623
Brugia malayi CXXC zinc finger family protein 0.0035 0.0126 0.0119
Schistosoma mansoni hypothetical protein 0.0041 0.0157 0.0325
Echinococcus multilocularis pyruvate kinase 0.0032 0.0112 0.0128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0007 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0097 0.1516
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0097 0.0575
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0094 0.1319
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0097 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0547 1
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0182 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0145 0.0416
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0547 1
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1009 0.4827 1
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0034 0.1334
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0547 0.1132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.005 0.0104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.009
Echinococcus multilocularis serotonin receptor 0.0148 0.0672 0.0769
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0097 0.0081
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0153 0.0454
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0034 0.0626
Loa Loa (eye worm) hypothetical protein 0.1063 0.5091 0.5087
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0145 0.2441
Echinococcus granulosus vesicular acetylcholine transporter 0.1009 0.4827 1
Leishmania major pyruvate kinase 0.004 0.0153 0.0137
Schistosoma mansoni thyroid hormone receptor 0.001 0.0007 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0126 0.0119
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0084 0.5
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0034 0.0018
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.0104
Schistosoma mansoni hypothetical protein 0.0165 0.0754 0.1562
Entamoeba histolytica hypothetical protein 0.0035 0.0128 0.2081
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Loa Loa (eye worm) pip kinase 2 0.0196 0.0906 0.09
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0084 0.013
Loa Loa (eye worm) MBCTL1 0.0053 0.0213 0.0207
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0084 0.0068
Loa Loa (eye worm) hypothetical protein 0.0109 0.0486 0.048
Onchocerca volvulus 0.0196 0.0906 0.1865
Onchocerca volvulus 0.0072 0.0307 0.0623
Brugia malayi vesicular acetylcholine transporter unc-17 0.1009 0.4827 0.4824
Mycobacterium ulcerans hypothetical protein 0.0072 0.0307 0.5487
Echinococcus multilocularis pyruvate kinase 0.0021 0.0058 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0642 0.0736
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0087 0.0071
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0007 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0087 0.0071
Brugia malayi Pip kinase protein 2 0.0196 0.0906 0.09
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.0034 0.0018
Trypanosoma brucei unspecified product 0.0039 0.0145 0.0129
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0307 0.5487
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0097 0.1516
Giardia lamblia Hypothetical protein 0.0016 0.0034 0.1334
Echinococcus multilocularis serotonin receptor 0.0148 0.0672 0.0769
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0642 0.1331
Brugia malayi mbt repeat family protein 0.0046 0.0182 0.0176
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0547 0.0626
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0097 0.1376
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.001 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.0713 0.1477
Loa Loa (eye worm) hypothetical protein 0.006 0.0249 0.0242
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0486 0.1007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0007 0.0014
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0007 0.0008
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0182 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Loa Loa (eye worm) hypothetical protein 0.208 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0307 0.0301
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0084 0.2423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0307 0.0636
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0642 0.0736
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0145 0.0138
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1009 0.4827 0.4824
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0097 0.019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0276 0.4891
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0153 0.0137
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0486 0.048
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0153 0.0146
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0307 1
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0145 0.0129
Loa Loa (eye worm) hypothetical protein 0.0047 0.0185 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0097 0.009
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.0404 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0185 0.5517
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0213 0.0442
Schistosoma mansoni vesicular acetylcholine transporter 0.1009 0.4827 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0145 0.03
Schistosoma mansoni hypothetical protein 0.0494 0.2343 0.4854
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0307 1
Echinococcus multilocularis geminin 0.0165 0.0754 0.0863
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0062 0.3326
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0307 0.0301
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0145 0.0129
Loa Loa (eye worm) hypothetical protein 0.0053 0.0213 0.0207
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.1334
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.0034 0.0018
Entamoeba histolytica hypothetical protein 0.0035 0.0128 0.2081
Schistosoma mansoni cpg binding protein 0.0037 0.0135 0.028
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0182 0.0378
Loa Loa (eye worm) hypothetical protein 0.0196 0.0906 0.09
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0307 0.0636
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0307 0.1179
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0007 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0007 0.0014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0062 0.0857
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0016 0.0034 0.0071
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.0713 0.0816
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0007 0.0014
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0185 0.0383
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0153 0.0303
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0007 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0307 0.1179
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0143 0.2383
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.0404 0.0398
Schistosoma mansoni cpg binding protein 0.0037 0.0135 0.028
Schistosoma mansoni thyroid hormone receptor 0.001 0.0007 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0128 0.0266
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0145 0.03
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0547 0.1132
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0185 0.0212
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0547 0.1132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.005 0.0044
Echinococcus multilocularis pyruvate kinase 0.0021 0.0058 0.0067
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.0034 0.0018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.0841 0.0963
Leishmania major pyruvate kinase 0.004 0.0153 0.0137
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0182 0.0378
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0307 0.1179
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0097 0.1516
Echinococcus multilocularis vesicular acetylcholine transporter 0.1009 0.4827 0.5528
Loa Loa (eye worm) FYVE zinc finger family protein 0.0016 0.0034 0.0028
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.0034 0.0018
Plasmodium falciparum pyruvate kinase 0.004 0.0153 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0145 0.0416
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0307 0.1179
Schistosoma mansoni pyruvate kinase 0.004 0.0153 0.0317
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0213 0.0207
Loa Loa (eye worm) hypothetical protein 0.0072 0.0307 0.0301
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.0034 0.0018
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0034 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0087 0.0071
Leishmania major hypothetical protein, conserved 0.0072 0.0307 0.0291
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0007 0.0014
Brugia malayi hypothetical protein 0.0035 0.0128 0.0122
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0062 0.0026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0145 0.03
Mycobacterium leprae Probable lipase LipE 0.0072 0.0307 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0182 0.0378
Echinococcus multilocularis protein dispatched 1 0.0054 0.0217 0.0248
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0097 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0307 1
Schistosoma mansoni coup transcription factor 0.001 0.0007 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0007 0.0014
Echinococcus multilocularis pyruvate kinase 0.0021 0.0058 0.0067
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0084 0.5
Echinococcus granulosus dna polymerase eta 0.0065 0.0271 0.0562
Mycobacterium tuberculosis Conserved protein 0.0072 0.0307 0.1179
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0097 0.0575
Loa Loa (eye worm) histone methyltransferase 0.0011 0.001 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0072 0.0307 0.0301
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.0672 0.1392
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2343 0.2683
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0271 0.0255
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0182 0.0378
Schistosoma mansoni pyruvate kinase 0.004 0.0153 0.0317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0009
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.0906 0.1038
Echinococcus granulosus pyruvate kinase 0.0021 0.0058 0.0121
Loa Loa (eye worm) hypothetical protein 0.0072 0.0307 0.0301
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0153 0.2577
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0547 0.0531
Brugia malayi Latrophilin receptor protein 2 0.0019 0.005 0.0044
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0007 0.0014
Schistosoma mansoni hypothetical protein 0.0045 0.0177 0.0366
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0146
Loa Loa (eye worm) pip kinase 1 0.0016 0.0034 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.2187 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0145 0.0129
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0249 0.0242
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0153 0.0146
Echinococcus multilocularis pyruvate kinase 0.004 0.0153 0.0175
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0153 0.4342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0314 0.065
Brugia malayi CHE-14 protein 0.0047 0.0185 0.0178
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0094 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.0672 0.1392
Echinococcus multilocularis expressed conserved protein 0.0103 0.0454 0.052
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.0104
Echinococcus granulosus pyruvate kinase 0.0021 0.0058 0.0121
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.0018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0307 0.1179
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0007 0.0014
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.0104
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0007 0.0014
Echinococcus granulosus geminin 0.0165 0.0754 0.1562
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0307 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0007 0.0014
Echinococcus multilocularis dna polymerase eta 0.0065 0.0271 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0642 0.1331
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0153 0.4342
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0128 0.0266
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0182 0.0364
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0044
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1817 0.8733 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.0906 0.1877
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0547 1
Brugia malayi mbt repeat family protein 0.0046 0.0182 0.0176
Giardia lamblia Pyruvate kinase 0.004 0.0153 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0065 0.0271 0.0264
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0007 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0249 0.0242
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0153 0.3093
Schistosoma mansoni patched 1 0.0047 0.0185 0.0383
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.005 0.0104
Trypanosoma brucei pyruvate kinase 1 0.004 0.0153 0.0137
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0547 1
Schistosoma mansoni DNA polymerase eta 0.0065 0.0271 0.0562
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0055
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0058 0.1443
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0642 0.0636
Loa Loa (eye worm) hypothetical protein 0.0072 0.0307 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0097 0.009
Echinococcus granulosus pyruvate kinase 0.0021 0.0058 0.0121
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0055
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0182 0.0378
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0097 0.1376
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0097 0.1376
Loa Loa (eye worm) hypothetical protein 0.0072 0.0307 0.0301
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.0034 0.0018
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0034 0.0344
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0307 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0153 0.0146
Echinococcus granulosus pyruvate kinase 0.004 0.0153 0.0317
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0145 0.0166
Schistosoma mansoni hypothetical protein 0.0282 0.132 0.2734
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1118 0.1112
Trypanosoma brucei unspecified product 0.0027 0.0087 0.0071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0236 0.0229
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0213 0.0442
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0016 0.0034 0.0071
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0153 0.0137
Schistosoma mansoni hypothetical protein 0.0035 0.0128 0.0266
Loa Loa (eye worm) hypothetical protein 0.0148 0.0672 0.0665
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0097 0.1516
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0547 0.2302
Schistosoma mansoni hypothetical protein 0.0045 0.0177 0.0366
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.0672 0.0665
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0213 0.0244
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0034 0.0344
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0642 0.0636
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.0906 0.1877
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.005 0.0044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0307 0.0352
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.0906 0.1877
Loa Loa (eye worm) pyruvate kinase 0.004 0.0153 0.0146
Echinococcus granulosus FTZ F1 alpha 0.001 0.0007 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Echinococcus granulosus pyruvate kinase 0.004 0.0153 0.0317
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0007 0.0014
Trypanosoma brucei C-8 sterol isomerase, putative 0.208 1 1
Onchocerca volvulus 0.0035 0.0126 0.0247
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0097 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0486 0.0557
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0007 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0642 0.1331
Onchocerca volvulus 0.0046 0.0182 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0084 0.1274
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0153 0.0137
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0084 0.1274
Schistosoma mansoni hypothetical protein 0.0045 0.0177 0.0366
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0034 0.0071
Trypanosoma cruzi C-8 sterol isomerase, putative 0.208 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0145 0.2423
Brugia malayi polk-prov protein 0.0012 0.0016 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0143 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0016 0.0034 0.0028
Entamoeba histolytica hypothetical protein 0.0026 0.0084 0.1091
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0084 0.1274
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0145 0.0129
Leishmania major DNA polymerase eta, putative 0.0065 0.0271 0.0255
Echinococcus granulosus GPCR family 2 0.0019 0.005 0.0104
Mycobacterium tuberculosis Conserved protein 0.0072 0.0307 0.1179
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0007 0.0008
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.0034 0.0018
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0034 0.0018
Mycobacterium tuberculosis Conserved protein 0.0072 0.0307 0.1179
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0097 0.1516
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.0404 0.0837
Mycobacterium ulcerans hypothetical protein 0.0029 0.0097 0.1516
Trypanosoma brucei unspecified product 0.0027 0.0087 0.0071
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0084 0.4943
Echinococcus multilocularis cpg binding protein 0.0037 0.0135 0.0155
Onchocerca volvulus 0.0072 0.0307 0.0623
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0145 0.0166
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0307 0.1179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.005 0.0058
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0034 0.0071
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0185 0.0383
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0307 1
Echinococcus granulosus cpg binding protein 0.0037 0.0135 0.028
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0213 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0642 0.1331
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0084 0.1274
Mycobacterium ulcerans lipase LipD 0.0072 0.0307 0.5487
Echinococcus granulosus expressed conserved protein 0.0103 0.0454 0.0941
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0084 0.2321
Mycobacterium ulcerans beta-lactamase 0.0072 0.0307 0.5487
Loa Loa (eye worm) hypothetical protein 0.0041 0.0157 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0307 0.0636
Brugia malayi beta-lactamase 0.0072 0.0307 0.0301
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0034 0.0039
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0182 0.0209
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0097 0.1516
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0307 0.0291
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0016 0.0034
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0486 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.001 0.0012
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0185 0.0178
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.0841 0.1742
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0307 0.5487
Toxoplasma gondii ABC1 family protein 0.0072 0.0307 0.5487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0642 0.1331
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0307 0.0291
Plasmodium vivax pyruvate kinase, putative 0.004 0.0153 0.4696
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0494 0.1024
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0145 0.2423
Echinococcus multilocularis GPCR, family 2 0.0019 0.005 0.0058
Schistosoma mansoni cpg binding protein 0.0035 0.0126 0.0261
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0307 0.1179
Giardia lamblia Pyruvate kinase 0.0021 0.0058 0.3073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0145 0.0129
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0307 0.0301
Onchocerca volvulus 0.0092 0.0404 0.0824
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0271 0.0255
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0058 0.3073
Loa Loa (eye worm) hypothetical protein 0.0092 0.0404 0.0398
Echinococcus multilocularis pyruvate kinase 0.004 0.0153 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0307 0.0291
Schistosoma mansoni hypothetical protein 0.0045 0.0177 0.0366
Brugia malayi follicle stimulating hormone receptor 0.024 0.1118 0.1112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0249 0.0242
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0034 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0145 0.4043
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0034 0.0018

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 54.9 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5702 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM ATP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 12.982 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate and 500microM CoASH. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.575 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.575 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM D-luciferin. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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