Detailed information for compound 675209

Basic information

Technical information
  • TDR Targets ID: 675209
  • Name: 2-[7-[(4-methoxyphenyl)methoxy]-4,8-dimethyl- 2-oxochromen-3-yl]acetic acid
  • MW: 368.38 | Formula: C21H20O6
  • H donors: 1 H acceptors: 3 LogP: 3.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)COc1ccc2c(c1C)oc(=O)c(c2C)CC(=O)O
  • InChi: 1S/C21H20O6/c1-12-16-8-9-18(26-11-14-4-6-15(25-3)7-5-14)13(2)20(16)27-21(24)17(12)10-19(22)23/h4-9H,10-11H2,1-3H3,(H,22,23)
  • InChiKey: MSOBEMBLPMHQGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[7-[(4-methoxyphenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]acetic acid
  • 2-[7-[(4-methoxyphenyl)methoxy]-4,8-dimethyl-2-oxo-3-chromenyl]acetic acid
  • 2-[2-keto-7-(4-methoxybenzyl)oxy-4,8-dimethyl-chromen-3-yl]acetic acid
  • 2-[7-[(4-methoxyphenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]ethanoic acid
  • EU-0046885
  • Oprea1_422797

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0006
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0013 0.3514
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0063 0.0063
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0011 0.0013 0.2063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0055 0.6657
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Brugia malayi Protein kinase domain containing protein 0.0006 0.0000000032682 0.0000000032682
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0063 0.6756
Schistosoma mansoni Smad4 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0006 0.0591
Schistosoma mansoni smad 0.0008 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0102 0.0102
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0003 0.0327
Echinococcus granulosus smad 0.0008 0.0006 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0063 0.0063
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0297 0.0298
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0034 0.4169
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0006 0.0006
Plasmodium vivax SET domain protein, putative 0.003 0.0063 1
Giardia lamblia Kinase, STE STE20 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000032682 0.000000054088
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0037 0.4515
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0082 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0093 0.031
Brugia malayi Inositol-1 0.0042 0.0093 0.0093
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0006 0.0672
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0529 0.053
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0093 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.3856 1 1
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0006 0.0000000032682 0.0000000032731
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Onchocerca volvulus 0.0027 0.0055 0.0904
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0013 0.1394
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0001 0.9999
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0055 0.6657
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1167 0.3016 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0093 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0006
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0013 0.0013
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0093 0.0093
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0093 1
Loa Loa (eye worm) brahma associated protein 0.0011 0.0013 0.0013
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0006 0.0672
Giardia lamblia Kinase, NEK 0.0006 0.0001 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0055 0.5848
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0013 0.0013
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0055 0.5848
Onchocerca volvulus 0.0008 0.0006 0.0091
Schistosoma mansoni protein kinase 0.3856 1 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0006 0.0672
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000032682 0.000000054088
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans hypothetical protein 0.0027 0.0055 0.5848
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000032682 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0063 0.0063
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0055 0.5848
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0013 0.0013
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0013 0.3514
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Schistosoma mansoni brg-1 associated factor 0.0011 0.0013 0.0013
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0006 0.1489
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Onchocerca volvulus 0.0011 0.0013 0.0216
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0093 1
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0037 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0006 0.0591
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.0209 0.0529 0.0529
Onchocerca volvulus 0.0238 0.0604 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0006 0.0591
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0055
Onchocerca volvulus 0.0008 0.0006 0.0091
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0006 0.0591
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0093 0.1546
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000032682 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0102 0.0102
Echinococcus multilocularis geminin 0.0191 0.0482 0.0482
Giardia lamblia Kinase 0.0006 0.0001 0.9999
Loa Loa (eye worm) Smad1 0.0008 0.0006 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0055 0.5848
Onchocerca volvulus 0.0008 0.0006 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0006 0.0006
Echinococcus granulosus Smad4 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0013 0.0013
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0055 0.0055
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1167 0.3016 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0055 0.0055
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.3856 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.1161 0.3001 0.3005
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0006 0.0591
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0006 0.0018
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0006 0.0591
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0006 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0102 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0034 0.4169
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0006 0.0672
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0034 0.4169
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0006
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0006 0.0006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000032682 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.003 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000000032682 0.0000000032731
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0006
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0006 0.0591
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0013 0.0013
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0013 0.0013
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0093 0.1546
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0063 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0006 0.0672
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0013
Chlamydia trachomatis SWIB complex protein 0.0011 0.0013 0.3514
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0001 0.0001
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0006 0.0591
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0013 0.2063
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Schistosoma mansoni inositol monophosphatase 0.0042 0.0093 0.0093
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0055 0.5848
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0006 0.0018
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0013
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0055 0.6657
Giardia lamblia Kinase, NEK-GL-like 0.0006 0.0000000032682 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0055 0.5848
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0055 0.5848
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000032682 0.000000054088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0034 0.4169
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0006 0.0672
Echinococcus granulosus geminin 0.0191 0.0482 0.0482
Schistosoma mansoni hypothetical protein 0.0191 0.0482 0.0482
Chlamydia trachomatis DNA topoisomerase I 0.0011 0.0013 0.3514
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0055 0.0055
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0006 0.0672
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Onchocerca volvulus 0.003 0.0063 0.1045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0093 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0063 0.0063
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0006 0.0672
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0006 0.0874
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0006 0.0672
Echinococcus multilocularis Smad4 0.0008 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0055 0.6657
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.006 0.006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0063 0.0063
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0055 0.5848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0102 0.0102
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0102 0.0102
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0006 0.0672
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1167 0.3016 0.302
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0297 0.0298
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) hypothetical protein 0.385 0.9985 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0006 0.0591
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0063 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0055 0.5848
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0037 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0013 0.0216
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0055 0.5848
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0006 0.0591
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0013 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0037 0.3966
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0006 0.0091
Brugia malayi MH2 domain containing protein 0.012 0.0297 0.0297
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0055
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000032682 0.0001
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0037 0.5871
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) inositol-1 0.0042 0.0093 0.0094
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0082 1
Echinococcus multilocularis smad 0.0008 0.0006 0.0006
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Brugia malayi Smad1 0.0008 0.0006 0.0006
Schistosoma mansoni protein kinase 0.3856 1 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trichomonas vaginalis harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative 0.0006 0.0000000032682 0.000000054088
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0093 0.0093
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0093 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0013 0.0013
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0006 0.0672
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0102 0.0102
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0006 0.0672
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0093 0.1546
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0006 0.0591
Brugia malayi Protein kinase domain containing protein 0.0006 0.0000000032682 0.0000000032682
Giardia lamblia Kinase 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0006 0.0018
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0055 0.5848
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0013 0.1394
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Schistosoma mansoni inositol monophosphatase 0.0042 0.0093 0.0093
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Onchocerca volvulus 0.0008 0.0006 0.0091
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0006 0.0672
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000032682 0.0001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Schistosoma mansoni hypothetical protein 0.0191 0.0482 0.0482
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0055 0.5848
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000032682 0.000000054088
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0006 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0055 0.5848
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0006 0.0591
Giardia lamblia Kinase, NEK 0.0006 0.0000000032682 0.0001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0102 0.0102
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0006 0.0672
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0102 0.0102

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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