Detailed information for compound 675648

Basic information

Technical information
  • TDR Targets ID: 675648
  • Name: (4Z)-4-[(3-bromo-5-chloro-2-methoxyphenyl)met hylidene]-2-prop-2-enylsulfanyl-1,3-thiazol-5 -one
  • MW: 404.73 | Formula: C14H11BrClNO2S2
  • H donors: 0 H acceptors: 1 LogP: 5.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCSC1=NC(=Cc2cc(Cl)cc(c2OC)Br)C(=O)S1
  • InChi: 1S/C14H11BrClNO2S2/c1-3-4-20-14-17-11(13(18)21-14)6-8-5-9(16)7-10(15)12(8)19-2/h3,5-7H,1,4H2,2H3/b11-6-
  • InChiKey: WMNVAZVZKMKFCJ-WDZFZDKYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4Z)-2-allylsulfanyl-4-[(3-bromo-5-chloro-2-methoxy-phenyl)methylene]thiazol-5-one
  • (4Z)-2-(allylthio)-4-[(3-bromo-5-chloro-2-methoxyphenyl)methylene]-5-thiazolone
  • (4Z)-2-(allylthio)-4-(3-bromo-5-chloro-2-methoxy-benzylidene)thiazol-5-one
  • (4Z)-4-[(3-bromo-5-chloro-2-methoxy-phenyl)methylidene]-2-prop-2-enylsulfanyl-1,3-thiazol-5-one
  • ZINC03461140

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0026 0.005 0.005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Chlamydia trachomatis DNA topoisomerase I 0.0011 0.0011 0.3307
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0004 0.0541
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0096 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0005 0.0005
Chlamydia trachomatis SWIB complex protein 0.0011 0.0011 0.3307
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.005 0.5797
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0541
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0058
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0004 0.0475
Echinococcus multilocularis Smad4 0.0008 0.0005 0.0005
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0075 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0004 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.4087
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.4087
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000030366 0.0001
Onchocerca volvulus 0.0008 0.0004 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.005 0.5797
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0004 0.0073
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0004 0.0541
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0011
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0011 0.3307
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0086 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Schistosoma mansoni Smad4 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0233 0.056 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0004 0.0004
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0004 0.0475
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0011 0.0011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0086 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0205 0.0491 0.0491
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0004 0.0541
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Onchocerca volvulus 0.0008 0.0004 0.0073
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative 0.0006 0.0000000030366 0.00000005419
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Brugia malayi Pre-SET motif family protein 0.0029 0.0058 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0491 0.0491
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0541
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0004 0.0475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.4087
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0033 0.4438
Giardia lamblia Kinase, NEK-GL-like 0.0006 0.0000000030366 0.0001
Echinococcus granulosus geminin 0.0187 0.0447 0.0447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0096 0.0096
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0011 0.0011
Brugia malayi Inositol-1 0.0041 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0058 0.0058
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, STE STE20 0.0006 0.0000000030366 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0004 0.0004
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0541
Onchocerca volvulus 0.0008 0.0004 0.0073
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0004 0.0475
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0033
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0004 0.0475
Onchocerca volvulus 0.0026 0.005 0.0887
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0058 0.0058
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.005 0.5797
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0011 0.1287
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0005 0.0005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0004 0.0541
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0004 0.0541
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0004 0.0475
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0005 0.0005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0033 0.3892
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0096 0.0096
Giardia lamblia Kinase, NEK 0.0006 0 0.9999
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0058 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0004 0.0004
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0004 0.0475
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0275 0.0275
Giardia lamblia Kinase 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0233 0.056 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0004 0.0475
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0004 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0058 0.6716
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0275 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0096 0.0096
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0004 0.0475
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.4056 1 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0075 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0096 0.0096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.005 0.661
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0004 0.0004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.005 0.5797
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000030366 0.00000005419
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Onchocerca volvulus 0.0008 0.0004 0.0073
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0004 0.0707
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0004 0.0004
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0011 0.1287
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000030366 0.00000005419
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0004 0.0014
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0005
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0011 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0005 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0026 0.005 0.005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.005 0.5797
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0086 0.153
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.005 0.5797
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0011 0.0011 0.1917
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000030366 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0011 0.1917
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0004 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0004 0.0004
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0026 0.005 0.005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0086 0.153
Brugia malayi Protein kinase domain containing protein 0.0006 0.0000000030366 0.0000000030366
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0187 0.0447 0.0447
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000030366 0.00000005419
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Onchocerca volvulus 0.0029 0.0058 0.1028
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.005 0.661
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Onchocerca volvulus 0.0011 0.0011 0.0197
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0086 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0058 0.0058
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0541
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0004 0.0475
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1227 0.3016 0.302
Echinococcus multilocularis geminin 0.0187 0.0447 0.0447
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0004 0.0014
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0033 0.5796
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0004 0.0004
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0006 0.0000000030366 0.0000000030412
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.005 0.5797
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0086 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0058
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.005 0.5797
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0005 0.0005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Schistosoma mansoni brg-1 associated factor 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0197
Brugia malayi Smad1 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0033
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.005 0.5797
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000000030366 0.0000000030412
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0033 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0033 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.005 0.5797
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0541
Echinococcus granulosus Smad4 0.0008 0.0005 0.0005
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0005
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.005 0.5797
Giardia lamblia Kinase 0.0006 0 0.9999
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0004 0.0541
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Schistosoma mansoni smad 0.0008 0.0005 0.0005
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0086 0.0086
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Schistosoma mansoni protein kinase 0.4056 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0086 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0096 0.0096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0086 0.153
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0033
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0086 0.5
Loa Loa (eye worm) hypothetical protein 0.405 0.9985 1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0187 0.0447 0.0447
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0004 0.0541
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) hypothetical protein 0.1221 0.3001 0.3005
Loa Loa (eye worm) brahma associated protein 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0004 0.0004
Giardia lamblia Kinase, NEK-like 0.0006 0.0000000030366 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0006 0.0000000030366 0.00000005419
Echinococcus granulosus smad 0.0008 0.0005 0.0005
Schistosoma mansoni protein kinase 0.4056 1 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.005 0.5797
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1227 0.3016 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.4056 1 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Echinococcus multilocularis smad 0.0008 0.0005 0.0005
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0011 0.0011
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0011 0.3307
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0004 0.0014
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0004 0.0541
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0096 0.0096
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.005 0.661
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) Smad1 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0033
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0001 0.0191
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0086 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0096 0.0096
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0004 0.0541
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0086 0.0086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.005 0.5797
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Plasmodium vivax SET domain protein, putative 0.0029 0.0058 1
Giardia lamblia Kinase, NEK-frag 0.0006 0.0000000030366 0.0001
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0004 0.0475
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0086 0.0284
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) oxidoreductase 0.0008 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0117 0.0275 0.0275
Brugia malayi Protein kinase domain containing protein 0.0006 0.0000000030366 0.0000000030366
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.005 0.5797
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0058 0.0058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0055 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.005 0.661
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0004 0.0475
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1227 0.3016 1
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Loa Loa (eye worm) inositol-1 0.0041 0.0086 0.0086
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0011 0.0011
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0004 0.0475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0031 0.4087
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0004 0.122
Schistosoma mansoni inositol monophosphatase 0.0041 0.0086 0.0086
Giardia lamblia Kinase, NEK 0.0006 0.0000000030366 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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