Detailed information for compound 680145

Basic information

Technical information
  • TDR Targets ID: 680145
  • Name: STK148337
  • MW: 443.278 | Formula: C21H18INO2
  • H donors: 1 H acceptors: 1 LogP: 5.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(c(c1)C)NC(=O)c1cccc(c1)OCc1ccccc1
  • InChi: 1S/C21H18INO2/c1-15-12-18(22)10-11-20(15)23-21(24)17-8-5-9-19(13-17)25-14-16-6-3-2-4-7-16/h2-13H,14H2,1H3,(H,23,24)
  • InChiKey: HTJVLDIGKAYKRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_462985

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0064 0.0095 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0103 0.0102
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0003 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Schistosoma mansoni ferritin light chain 0.0018 0.0005 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0062 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0133
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0011 0.0133
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0003 0.0001
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0065 0.0764
Brugia malayi Heterochromatin protein 1 0.0072 0.0111 0.1312
Echinococcus granulosus dna polymerase eta 0.002 0.0009 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0003 0.0045
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2248 0.441 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0037 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0026 0.0259
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0009 0.0013
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0064 0.0095 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0163 0.0162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0064
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0115 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0011 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0049 0.0491
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0137 0.1627
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0003 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0125 0.0123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0103 0.1219
Echinococcus granulosus smad 0.0017 0.0003 0.0002
Echinococcus multilocularis geminin 0.0174 0.0313 0.0312
Schistosoma mansoni hypothetical protein 0.0174 0.0313 0.0312
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0403
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0166 0.0297 0.8929
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0115 0.3393
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Echinococcus multilocularis Smad4 0.0017 0.0003 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0009 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0133
Schistosoma mansoni Smad4 0.0017 0.0003 0.0002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0003 0.0001
Mycobacterium ulcerans beta-lactamase 0.0073 0.0115 0.0253
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0011 0.0133
Echinococcus multilocularis pyruvate kinase 0.0027 0.0023 0.0022
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0041 0.004
Echinococcus multilocularis pyruvate kinase 0.0034 0.0037 0.0036
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0064 0.0095 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0174 0.2056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0026 0.0259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0005 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0011 0.001
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0137 0.1627
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0023 0.0642
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0219
Echinococcus multilocularis dna polymerase kappa 0.002 0.0009 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0197
Onchocerca volvulus 0.0021 0.0011 0.0088
Echinococcus granulosus thioredoxin glutathione reductase 0.0185 0.0334 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0095 0.0094
Mycobacterium ulcerans transcriptional regulator 0.2252 0.4418 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0065 0.0656
Giardia lamblia Pyruvate kinase 0.0018 0.0004 0.0148
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0166 0.0297 0.8929
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0177 0.0319 0.0318
Brugia malayi glutathione reductase 0.0184 0.0332 0.3934
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0065 0.5062
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.005 0.0068 0.1972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0051 0.0511
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0064 0.0095 0.1127
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0166 0.0297 0.0296
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0023 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403
Trichomonas vaginalis set domain proteins, putative 0.0504 0.0965 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0133
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0115 0.0254
Brugia malayi steroid hormone receptor 0.0021 0.0011 0.0133
Echinococcus granulosus pyruvate kinase 0.0018 0.0004 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0041 0.004
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.0033
Echinococcus multilocularis lamin dm0 0.0029 0.0026 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0018 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.049
Plasmodium falciparum phd finger protein, putative 0.003 0.0029 0.0783
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0208
Echinococcus multilocularis smad 0.0017 0.0003 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0064 0.0095 0.2803
Loa Loa (eye worm) hypothetical protein 0.0085 0.0137 0.1627
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0102
Schistosoma mansoni apoferritin-2 0.0018 0.0005 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0064 0.0095 0.2835
Onchocerca volvulus 0.0029 0.0026 0.0246
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0005 0.0005
Echinococcus granulosus peregrin 0.003 0.0029 0.0027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0115 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0103 0.0102
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0115 0.3422
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0115 0.1356
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0064 0.0095 0.2835
Echinococcus multilocularis ferritin 0.0018 0.0005 0.0004
Echinococcus multilocularis L aminoadipate semialdehyde 0.0177 0.0319 0.0318
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0095 0.0094
Echinococcus multilocularis pyruvate kinase 0.0018 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0003 0.0001
Schistosoma mansoni glutamate synthase 0.0017 0.0003 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0115 0.1356
Onchocerca volvulus 0.0054 0.0076 0.0756
Plasmodium falciparum glutathione reductase 0.0064 0.0095 0.2803
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1356
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.005 0.0068 0.2208
Schistosoma mansoni hypothetical protein 0.0085 0.0137 0.0136
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0137 0.0136
Giardia lamblia GTOR 0.0048 0.0065 0.6686
Treponema pallidum NADH oxidase 0.0064 0.0095 0.314
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0003 0.0015
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0045 0.1325
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0003 0.0045
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0037 0.1081
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0011 0.0088
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0011 0.001
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0005 0.0078
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0011 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0062 0.0061
Brugia malayi beta-lactamase family protein 0.0073 0.0115 0.1356
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0015
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.0068 0.1972
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.1208
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0037 0.0439
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0109 0.0184 0.0411
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0045
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0009 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0184 0.0332 0.0747
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0011 0.0088
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0064 0.0095 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0208
Schistosoma mansoni lamin 0.0029 0.0026 0.0025
Echinococcus granulosus expressed protein 0.0018 0.0005 0.0004
Schistosoma mansoni chromobox protein 0.0072 0.0111 0.0109
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0009 0.0007
Schistosoma mansoni coup transcription factor 0.0021 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0201
Brugia malayi RNA binding protein 0.0068 0.0103 0.1219
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0419 0.0797 0.1802
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0111 0.1312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0133
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0037 0.1041
Brugia malayi jmjC domain containing protein 0.0098 0.0163 0.1932
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0005 0.0077
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0037 0.0439
Plasmodium falciparum thioredoxin reductase 0.0064 0.0095 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.009 0.0089
Trichomonas vaginalis mercuric reductase, putative 0.0064 0.0095 0.0973
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0115 0.1175
Schistosoma mansoni peptidase Clp (S14 family) 0.0166 0.0297 0.0296
Onchocerca volvulus 0.0024 0.0018 0.0153
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0029 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0003 0.0045
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0029 0.0783
Schistosoma mansoni glutamate synthase 0.0017 0.0003 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0219
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0017 0.1134
Brugia malayi nuclear receptor NHR-88 0.0021 0.0011 0.0133
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0095 0.2797
Echinococcus granulosus chromobox protein 1 0.0072 0.0111 0.0109
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0137 0.0136
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0026 0.0314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0034 0.0403
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0419 0.0797 0.1802
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0018 0.1208
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0003 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403
Echinococcus granulosus pyruvate kinase 0.0018 0.0004 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0103 0.1219
Brugia malayi TAR-binding protein 0.0068 0.0103 0.1219
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0064 0.0095 0.2803
Onchocerca volvulus 0.0075 0.0118 0.1198
Plasmodium vivax thioredoxin reductase, putative 0.0184 0.0332 1
Trypanosoma brucei unspecified product 0.002 0.0009 0.0219
Schistosoma mansoni hypothetical protein 0.0085 0.0137 0.0136
Mycobacterium ulcerans lipase LipD 0.0073 0.0115 0.0253
Trypanosoma brucei trypanothione reductase 0.0184 0.0332 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0177 0.0319 0.0318
Onchocerca volvulus 0.0073 0.0115 0.1161
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0029 0.0027
Brugia malayi glutamate synthase 0.0017 0.0003 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.001
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0065 0.191
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0276 0.0275
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0038
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0177 0.0319 0.3777
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0017 0.0197
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.004 0.1134
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0057 0.0082 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0095 0.2835
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0062 0.0737
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0062 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0055 0.0553
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0109 0.0184 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0133
Schistosoma mansoni lamin 0.0029 0.0026 0.0025
Brugia malayi PHD-finger family protein 0.003 0.0029 0.0338
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0003 0.0045
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.0062 0.0731
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0009 0.0102
Echinococcus granulosus glutamate synthase 0.0017 0.0003 0.0001
Echinococcus granulosus GPCR family 2 0.0033 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Schistosoma mansoni intermediate filament proteins 0.0029 0.0026 0.0025
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.1208
Schistosoma mansoni pyruvate kinase 0.0034 0.0037 0.0036
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0082 0.2412
Schistosoma mansoni ferritin 0.0018 0.0005 0.0004
Leishmania major hypothetical protein, conserved 0.0027 0.0023 0.0642
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0103 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0041 0.004
Toxoplasma gondii ABC1 family protein 0.0073 0.0115 0.3393
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0064 0.0095 0.2835
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0095 0.314
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0023 0.06
Echinococcus granulosus lamin dm0 0.0029 0.0026 0.0025
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.0068 0.2208
Echinococcus granulosus lamin 0.0029 0.0026 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0118 0.0117
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.0068 0.1972
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0037 0.1081
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0009 0.0102
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1291
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Giardia lamblia Pyruvate kinase 0.0034 0.0037 0.3715
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Echinococcus granulosus tar DNA binding protein 0.0068 0.0103 0.0102
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0003 0.0001
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0115 0.0253
Leishmania major hypothetical protein, conserved 0.0073 0.0115 0.3422
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0011 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.0465 0.5507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0301
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0003 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0095 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0026 0.0253
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0095 0.2835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0137 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0023 0.06
Brugia malayi hypothetical protein 0.0017 0.0004 0.0044
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0003 0.0001
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0003 0.0033
Echinococcus multilocularis pyruvate kinase 0.0034 0.0037 0.0036
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0029 0.0338
Brugia malayi Bromodomain containing protein 0.003 0.0029 0.0338
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0045 0.1325
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0003 0.0045
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0029 0.0027
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.049 0.0488
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0045
Leishmania major DNA polymerase eta, putative 0.002 0.0009 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0115 0.3422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0062 0.0061
Schistosoma mansoni ferritin 0.0018 0.0005 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0111 0.1135
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0005 0.0077
Schistosoma mansoni pyruvate kinase 0.0034 0.0037 0.0036
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0023 0.06
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0115 0.1175
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0003 0.0001
Loa Loa (eye worm) Smad1 0.0017 0.0003 0.0038
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0026 0.0314
Schistosoma mansoni hypothetical protein 0.0085 0.0137 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0064 0.0095 0.2803
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0023 0.0642
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Chlamydia trachomatis pyruvate kinase 0.0034 0.0037 0.1166
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0055 0.0553
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0034 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0009 0.0013
Schistosoma mansoni ferritin light chain 0.0018 0.0005 0.0004
Onchocerca volvulus 0.0504 0.0965 1
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0045
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0037 0.1081
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0115 0.1175
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0037 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0026 0.0259
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0011 0.001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1356
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0003 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0033
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0009 0.0219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0115 0.0113
Echinococcus multilocularis pyruvate kinase 0.0018 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Schistosoma mansoni hypothetical protein 0.0079 0.0125 0.0123
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0064 0.0095 0.2835
Echinococcus granulosus ferritin 0.0018 0.0005 0.0004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Echinococcus granulosus pyruvate kinase 0.0018 0.0004 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0419 0.0797 0.1798
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0003 0.0001
Toxoplasma gondii hypothetical protein 0.0057 0.0082 0.2412
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0005 0.0005
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0045
Giardia lamblia DINP protein human, muc B family 0.002 0.0009 0.0626
Brugia malayi chromobox protein homolog 3 0.004 0.0049 0.0576
Leishmania major pyruvate kinase 0.0034 0.0037 0.1081
Plasmodium vivax glutathione reductase, putative 0.0184 0.0332 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0029 0.0783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0045 0.0454
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0015
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.0068 0.0147
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0037 0.0439
Mycobacterium tuberculosis Conserved protein 0.0073 0.0115 0.0254
Loa Loa (eye worm) RNA binding protein 0.0068 0.0103 0.1219
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0115 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0133
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0082 0.2702
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0276 0.0275
Schistosoma mansoni glutamate synthase 0.0017 0.0003 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0208
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0009 0.0075
Mycobacterium tuberculosis Conserved protein 0.0073 0.0115 0.0254
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0018 0.0033
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 1
Brugia malayi hypothetical protein 0.0263 0.049 0.5801
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0065 0.191
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0092 0.1084
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0003 0.0015
Plasmodium vivax hypothetical protein, conserved 0.003 0.0029 0.0783
Schistosoma mansoni smad 0.0017 0.0003 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0208
Echinococcus granulosus geminin 0.0174 0.0313 0.0312
Onchocerca volvulus 0.0073 0.0115 0.1161
Treponema pallidum 4'-phosphopantetheinyl transferase 0.005 0.0068 0.2208
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0115 0.0254
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0045 0.1325
Loa Loa (eye worm) glutathione reductase 0.0184 0.0332 0.3934
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.0033
Schistosoma mansoni ferritin 0.0018 0.0005 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0115 0.3422
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.005 0.0068 0.5326
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0003 0.0015
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.0068 0.0147
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0095 0.2835
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0003 0.0033
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0037 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0026 0.0253
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0011 0.0133
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0166 0.0297 0.0296
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0005 0.0078
Echinococcus multilocularis microtubule associated protein 2 0.5078 1 1
Onchocerca volvulus 0.0177 0.0319 0.3285
Schistosoma mansoni hypothetical protein 0.0033 0.0034 0.0033
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0003 0.0015
Schistosoma mansoni hypothetical protein 0.0054 0.0076 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0065 0.0656
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.0062 0.0731
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0011 0.001
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0003 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0026 0.0251
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0466 0.0889 0.2011
Loa Loa (eye worm) hypothetical protein 0.0064 0.0095 0.1124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0095 0.0094
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0037 0.1081
Schistosoma mansoni hypothetical protein 0.0071 0.0109 0.0108
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0003 0.0015
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Echinococcus granulosus intermediate filament protein 0.0029 0.0026 0.0025
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0001 0.0016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0466 0.0889 0.2007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0011 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0018 0.0033
Brugia malayi Thioredoxin reductase 0.0184 0.0332 0.3934
Loa Loa (eye worm) hypothetical protein 0.0051 0.0071 0.0839
Entamoeba histolytica hypothetical protein 0.0079 0.0125 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0443 0.0844 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0133
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0068 0.2007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403
Trichomonas vaginalis ferritin, putative 0.0018 0.0005 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0062 0.0061
Schistosoma mansoni hypothetical protein 0.0033 0.0034 0.0033
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0037 0.0371
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0115 0.0253
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0137 0.0136
Schistosoma mansoni DNA polymerase eta 0.002 0.0009 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0064 0.0095 0.0094
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0219
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0065 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0133
Leishmania major DNA polymerase kappa, putative 0.002 0.0009 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0133
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0009 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0003 0.0001
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0037 0.0078
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0037 0.0078
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0003 0.0033
Onchocerca volvulus 0.0031 0.0032 0.0299
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0003 0.0045
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0065 0.191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0065 0.191
Schistosoma mansoni hypothetical protein 0.0033 0.0034 0.0033
Onchocerca volvulus Alhambra homolog 0.003 0.0029 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0011 0.0133
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Brugia malayi jmjC domain containing protein 0.0036 0.0041 0.0486
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0009 0.0219
Leishmania major trypanothione reductase 0.0184 0.0332 1
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.0465 0.5507
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0026 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0174 0.2056
Entamoeba histolytica hypothetical protein 0.0079 0.0125 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0174 0.2056
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0115 0.0254
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0005 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.001
Echinococcus multilocularis expressed protein 0.0018 0.0005 0.0004
Echinococcus multilocularis peregrin 0.003 0.0029 0.0027
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0064
Schistosoma mansoni hypothetical protein 0.003 0.0029 0.0027
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0003 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0034 0.0403
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0219
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0037 0.0356
Trypanosoma cruzi trypanothione reductase, putative 0.0184 0.0332 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0103 0.0102
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0003 0.0038
Brugia malayi intermediate filament protein 0.0029 0.0026 0.0314
Schistosoma mansoni cellular tumor antigen P53 0.0158 0.0282 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0133
Echinococcus granulosus dna polymerase kappa 0.002 0.0009 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.5078 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0045 0.0454
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0034 0.0033
Brugia malayi Pre-SET motif family protein 0.0064 0.0095 0.1124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0033 0.0331
Onchocerca volvulus 0.0073 0.0115 0.1161
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0011 0.0088
Mycobacterium tuberculosis Probable reductase 0.0419 0.0797 0.1802
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0219
Brugia malayi hypothetical protein 0.0079 0.0125 0.1477
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0065 0.0063
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0076 0.0895
Toxoplasma gondii NADPH-glutathione reductase 0.0064 0.0095 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0095 0.0094
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0065 0.0764
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0009 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0064 0.0095 0.0209
Brugia malayi beta-lactamase 0.0073 0.0115 0.1356
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0018 0.0033
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0045 0.0454
Loa Loa (eye worm) hypothetical protein 0.0263 0.049 0.5801
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0003 0.0038
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0009 0.0013
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0015
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.0068 0.1972
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Echinococcus granulosus tumor protein p63 0.1082 0.2106 0.2105
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0109 0.1291
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0133
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0125 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0033
Echinococcus granulosus pyruvate kinase 0.0034 0.0037 0.0036
Giardia lamblia NADH oxidase lateral transfer candidate 0.0064 0.0095 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0115 0.0113
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0082 0.2412
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0003 0.0001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0166 0.0297 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0049 0.0491
Brugia malayi beta-lactamase family protein 0.0073 0.0115 0.1356
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 0.8929
Loa Loa (eye worm) thioredoxin reductase 0.0184 0.0332 0.3934
Echinococcus granulosus chromobox protein 1 0.0072 0.0111 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0276 0.0275
Echinococcus multilocularis tumor protein p63 0.1082 0.2106 0.2105
Brugia malayi Pre-SET motif family protein 0.0443 0.0844 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0109 0.0184 0.0183
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0003 0.0033
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0163 0.0162
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0018 0.0033
Leishmania major pyruvate kinase 0.0034 0.0037 0.1081
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0115 0.0253
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0373
Entamoeba histolytica hypothetical protein 0.0079 0.0125 1
Plasmodium falciparum thioredoxin reductase 0.0184 0.0332 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0062 0.0737
Brugia malayi ecdysteroid receptor 0.0021 0.0011 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0103 0.0102
Plasmodium falciparum glutathione reductase 0.0184 0.0332 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0095 0.2835
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0095 0.314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0062 0.0061
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0003 0.0001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0009 0.023
Trichomonas vaginalis esterase, putative 0.0073 0.0115 0.1175
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0158 0.0282 0.3343
Schistosoma mansoni hypothetical protein 0.0134 0.0235 0.0233
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0419 0.0797 0.1802
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0037 0.1041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.0896 0.2028
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0065 0.191
Onchocerca volvulus 0.0158 0.0282 0.2904
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0037 0.0356
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0052 0.005
Mycobacterium leprae Probable lipase LipE 0.0073 0.0115 0.0253
Schistosoma mansoni survival motor neuron protein 0.0054 0.0076 0.0074
Echinococcus multilocularis chromobox protein 1 0.0072 0.0111 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0202
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1356
Echinococcus granulosus peptidase Clp S14 family 0.0109 0.0184 0.0183
Toxoplasma gondii thioredoxin reductase 0.0184 0.0332 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0109 0.0184 0.041
Echinococcus multilocularis GPCR, family 2 0.0033 0.0034 0.0033
Plasmodium vivax SET domain protein, putative 0.0064 0.0095 0.2797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403
Mycobacterium tuberculosis Conserved protein 0.0073 0.0115 0.0254
Trichomonas vaginalis glutathione reductase, putative 0.0064 0.0095 0.0973
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0095 0.0094
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0055 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0103 0.0102
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0103 0.1219
Echinococcus multilocularis dna polymerase eta 0.002 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1356
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0001 0.0016
Echinococcus multilocularis chromobox protein 1 0.0072 0.0111 0.0109
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0134 0.0235 0.0233
Schistosoma mansoni ferritin 0.0018 0.0005 0.0004
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0137 0.0136
Mycobacterium leprae conserved hypothetical protein 0.005 0.0068 0.0147
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0005 0.0087
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.001
Loa Loa (eye worm) beta-lactamase 0.0073 0.0115 0.1356
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0003 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0045 0.0454
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0125 0.0123
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0041 0.004
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0045
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.0068 0.2007
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0134 0.0235 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0202
Mycobacterium ulcerans TetR family transcriptional regulator 0.2252 0.4418 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0003 0.0045
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0014 0.0395
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0011 0.0133
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0038
Echinococcus multilocularis lamin 0.0029 0.0026 0.0025
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0064 0.0095 0.314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0034 0.0403
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0004 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0011 0.001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0466 0.0889 0.2011
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1356
Brugia malayi Smad1 0.0017 0.0003 0.0038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0011 0.001
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0003 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0166 0.0297 0.8929
Schistosoma mansoni hypothetical protein 0.0174 0.0313 0.0312
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0115 0.1175
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0009 0.0075
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0133
Loa Loa (eye worm) hypothetical protein 0.0073 0.0115 0.1356
Echinococcus multilocularis musashi 0.0029 0.0026 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0037 0.0439
Giardia lamblia PHD finger protein 15 0.003 0.0029 0.2791
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0011 0.001
Schistosoma mansoni chromobox protein 0.0072 0.0111 0.0109
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0011 0.001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0115 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0045 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0133
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0064 0.0095 0.0209
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2252 0.4418 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0208
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2252 0.4418 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0009 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0115 0.0254
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0003 0.0045
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0267
Schistosoma mansoni pyruvate kinase 0.0018 0.0004 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0041 0.0486
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0123 0.0122
Echinococcus granulosus pyruvate kinase 0.0034 0.0037 0.0036
Brugia malayi Probable ClpP-like protease 0.0166 0.0297 0.3516
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0314
Brugia malayi nuclear hormone receptor 0.0021 0.0011 0.0133
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0003 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0185 0.0334 0.0333
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0023 0.06
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0111 0.1135
Mycobacterium tuberculosis Probable dehydrogenase 0.0419 0.0797 0.1802
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0219
Entamoeba histolytica hypothetical protein 0.0079 0.0125 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0065 0.191
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0419 0.0797 0.1802
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0166 0.0297 0.3516
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0137 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0062 0.0061
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 0.0666
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0011 0.001
Plasmodium falciparum pyruvate kinase 0.0034 0.0037 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0031 0.031
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0009 0.0219
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0049 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0201
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0037 0.0439
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0037 0.0439
Schistosoma mansoni apoferritin-2 0.0018 0.0005 0.0004
Echinococcus granulosus Smad4 0.0017 0.0003 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0466 0.0889 0.2011
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0011 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0095 0.2835
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0011 0.001
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Onchocerca volvulus 0.0029 0.0026 0.0246
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0133
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0003 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0115 0.0113
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0133
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0065 0.5062
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0065 0.0656
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.049 0.0488
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0166 0.0297 0.0666
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0003 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0009 0.0007
Brugia malayi hypothetical protein 0.0027 0.0023 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0133
Leishmania major NADH dehydrogenase, putative 0.0017 0.0003 0.0045
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0003 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0177 0.0319 0.3777
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0219
Brugia malayi MH2 domain containing protein 0.0251 0.0465 0.5507
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.0068 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0095 0.2835
Schistosoma mansoni hypothetical protein 0.0033 0.0034 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0115 0.1175
Loa Loa (eye worm) hypothetical protein 0.0103 0.0174 0.2056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0026 0.0314
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0064 0.0095 0.0209
Echinococcus multilocularis glutamate synthase 0.0017 0.0003 0.0001
Mycobacterium ulcerans hypothetical protein 0.0073 0.0115 0.0253
Echinococcus multilocularis pyruvate kinase 0.0018 0.0004 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0064 0.0095 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.0403

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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