Detailed information for compound 680723

Basic information

Technical information
  • TDR Targets ID: 680723
  • Name: 1-(4-chloro-2-methylphenyl)-4-(4-methylpipera zin-1-yl)pyrazolo[4,5-e]pyrimidine
  • MW: 342.826 | Formula: C17H19ClN6
  • H donors: 0 H acceptors: 3 LogP: 3.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1ncnc2c1cnn2c1ccc(cc1C)Cl
  • InChi: 1S/C17H19ClN6/c1-12-9-13(18)3-4-15(12)24-17-14(10-21-24)16(19-11-20-17)23-7-5-22(2)6-8-23/h3-4,9-11H,5-8H2,1-2H3
  • InChiKey: SQAIWLIRHFJIFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chloro-2-methyl-phenyl)-4-(4-methylpiperazin-1-yl)pyrazolo[4,5-e]pyrimidine
  • 1-(4-chloro-2-methylphenyl)-4-(4-methyl-1-piperazinyl)pyrazolo[4,5-e]pyrimidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.7087 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.06 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0155 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0047 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1342 0.1342
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus RUN 0.0066 0.127 0.127
Brugia malayi intermediate filament protein 0.003 0.0467 0.086
Plasmodium vivax JmjC domain containing protein 0.0017 0.0186 0.0072
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.1322 0.3869
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.7087 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0047 0.0012
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0236 0.0364
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0309 0.4052
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0555 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0047 0.0012
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.05 0.0925
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0047 0.0047
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.1008 0.1008
Brugia malayi cytochrome P450 0.002 0.0236 0.0393
Onchocerca volvulus 0.0264 0.572 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0236 0.0595
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.131 0.131
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.2773 0.5532
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0236 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0485 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0236 0.0364
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0155 0.023
Loa Loa (eye worm) intermediate filament protein 0.003 0.0467 0.091
Brugia malayi steroid hormone receptor 0.0011 0.0047 0.0012
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0236 0.0388
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.7087 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0118 0.0118
Trypanosoma cruzi hexose transporter 0.0032 0.0509 0.8139
Loa Loa (eye worm) sugar transporter 0.0014 0.0118 0.0211
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0455 0.1254
Brugia malayi STAT protein, DNA binding domain containing protein 0.0161 0.3399 0.6767
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0186 0.0346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0025 0.0356 0.0687
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.05 0.0404
Schistosoma mansoni hypothetical protein 0.002 0.0236 0.0236
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0485 0.0485
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0309 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0118 0.0118
Onchocerca volvulus 0.0032 0.0511 0.0819
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0186 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0077 0.0077
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Loa Loa (eye worm) doublecortin family protein 0.0066 0.127 0.252
Plasmodium falciparum LCCL domain-containing protein 0.0066 0.127 0.1219
Brugia malayi Sugar transporter family protein 0.0014 0.0118 0.0156
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.131 0.3678
Echinococcus granulosus Polycystic kidney disease protein 0.0066 0.127 0.127
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Onchocerca volvulus 0.0014 0.0118 0.0126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0309 0.0813
Schistosoma mansoni hypothetical protein 0.0066 0.127 0.127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0455 0.0886
Trichomonas vaginalis set domain proteins, putative 0.0264 0.572 0.8041
Schistosoma mansoni lipoxygenase 0.0254 0.5492 0.5492
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0309 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0047 0.0012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.1262 0.1262
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0692 0.0692
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0186 0.0346
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0236 0.0364
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0186 0.1549
Schistosoma mansoni protein kinase 0.0031 0.05 0.05
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.06 0.0779
Schistosoma mansoni cpg binding protein 0.0034 0.0552 0.0552
Schistosoma mansoni hypothetical protein 0.0103 0.2097 0.2097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0509 0.0571
Schistosoma mansoni glucose transport protein 0.0103 0.2097 0.2097
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0236 0.0595
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.1188 0.2355
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0107 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0309 0.0309
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0236 0.0595
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0485 0.0261
Mycobacterium ulcerans putative regulatory protein 0.004 0.0693 0.1972
Echinococcus multilocularis lamin 0.003 0.0467 0.0467
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0118 0.0156
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0455 0.7037
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.0028 0.0424 0.2586
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0309 0.0273
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0047 0.0067
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0455 0.0885
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0047 0.0012
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0485 0.0485
Schistosoma mansoni single-minded 0.0054 0.1008 0.1008
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0309 0.0308
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0047 0.0067
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0185 0.1529
Echinococcus multilocularis General substrate transporter 0.0088 0.1773 0.1773
Schistosoma mansoni protein kinase 0.0031 0.05 0.05
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0236 0.0595
Echinococcus multilocularis RUN 0.0066 0.127 0.127
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0509 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0107 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Echinococcus multilocularis cpg binding protein 0.0034 0.0552 0.0552
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.05 0.0404
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0555 0.0555
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0118 0.5
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.05 0.0404
Brugia malayi Doublecortin family protein 0.0066 0.127 0.2478
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0047 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0047 0.0047
Mycobacterium ulcerans sugar transporter 0.0014 0.0118 0.024
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0236 0.0595
Brugia malayi Sugar transporter family protein 0.0103 0.2097 0.4144
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0186 0.1549
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0047 0.0047
Brugia malayi hypothetical protein 0.0014 0.0118 0.0156
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0047 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.011 0.011
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.011 0.011
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0236 0.0595
Onchocerca volvulus 0.0014 0.0118 0.0126
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Onchocerca volvulus 0.0014 0.0118 0.0126
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Onchocerca volvulus 0.004 0.0693 0.1139
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.06 0.404
Schistosoma mansoni rab6-interacting 0.0066 0.127 0.127
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.06 1
Schistosoma mansoni jumonji domain containing protein 0.0065 0.1262 0.1262
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0047 0.0047
Echinococcus multilocularis Polycystic kidney disease protein 0.0066 0.127 0.127
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.011 0.0194
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0047 0.0047
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0186 0.0186
Echinococcus granulosus phd:f box containing protein 0.0017 0.0186 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.002 0.0236 0.0393
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0118 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.131 0.1927
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0236 0.0364
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.1303 0.1303
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0236 0.0364
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0118 0.0156
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0555 0.0555
Schistosoma mansoni glucose transporter 0.0014 0.0118 0.0118
Brugia malayi nuclear hormone receptor 0.0011 0.0047 0.0012
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0118 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0509 0.0571
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0047 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0236 0.0364
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.127 0.127
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0509 0.3288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0186 0.0186
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.05 0.0975
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0047 0.0067
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0077 0.0077
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0236 0.0595
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0118 0.024
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0236 0.0595
Leishmania major protein kinase, putative 0.0016 0.0154 0.0363
Leishmania major protein kinase, putative 0.0031 0.05 0.3214
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0231 0.0348
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0424 0.64
Loa Loa (eye worm) STAT protein 0.0161 0.3399 0.6785
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0186 0.0186
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0509 0.8139
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0509 0.8107
Echinococcus granulosus General substrate transporter 0.0088 0.1773 0.1773
Schistosoma mansoni lipoxygenase 0.0136 0.2836 0.2836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0047 0.0067
Onchocerca volvulus 0.0014 0.0118 0.0126
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0693 0.0693
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0119 0.0119
Brugia malayi hypothetical protein 0.0028 0.0424 0.0771
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0118 0.0118
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0309 0.395
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.1322 0.2582
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0047 0.0047
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0227 0.0227
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0047 0.0047
Leishmania major cytochrome p450-like protein 0.002 0.0236 0.104
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 0.9567 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0047 0.0012
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2097 0.2848
Plasmodium falciparum proline--tRNA ligase 0.0036 0.06 0.051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0455 0.7037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0047 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0346
Loa Loa (eye worm) hypothetical protein 0.0014 0.0119 0.0213
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus intermediate filament protein 0.003 0.0467 0.0467
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0236 0.0364
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.7087 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0047 0.0047
Mycobacterium leprae putative cytochrome p450 0.002 0.0236 0.0388
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0309 0.0813
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.1322 0.3718
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0555 0.1086
Schistosoma mansoni cpg binding protein 0.0032 0.0511 0.0511
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0236 0.0595
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0485 0.0896
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0231 0.0373
Loa Loa (eye worm) hypothetical protein 0.0031 0.0485 0.0946
Schistosoma mansoni hypothetical protein 0.004 0.0692 0.0692
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0455 0.6986
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0231 0.0348
Echinococcus multilocularis lamin dm0 0.003 0.0467 0.0467
Onchocerca volvulus 0.003 0.0467 0.0741
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0236 0.2574
Brugia malayi Pre-SET motif family protein 0.0232 0.5003 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0047 0.0067
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Leishmania major protein kinase, putative 0.0016 0.0154 0.0363
Schistosoma mansoni hypothetical protein 0.0455 1 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Trypanosoma brucei glucose transporter 1E 0.0032 0.0509 0.8107
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0309 0.0201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.05 0.0404
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Leishmania major glucose transporter, lmgt1 0.0032 0.0509 0.3288
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.05 0.0404
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0047 0.0047
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.1322 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.06 0.404
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0236 0.2446
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0485 0.0485
Leishmania major glucose transporter, lmgt3 0.0032 0.0509 0.3288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0555 0.0555
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0047 0.0047
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.05 0.7919
Brugia malayi CXXC zinc finger family protein 0.0032 0.0511 0.0948
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2097 0.2097
Onchocerca volvulus 0.0014 0.0118 0.0126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Loa Loa (eye worm) hypothetical protein 0.0031 0.05 0.0975
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0509 0.8139
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0511 0.0998
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0424 0.0323
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0309 0.0201
Brugia malayi nuclear receptor NHR-88 0.0011 0.0047 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Brugia malayi hypothetical protein 0.0066 0.127 0.2478
Entamoeba histolytica protein kinase, putative 0.0031 0.05 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0047 0.0012
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0118 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni protein kinase 0.0031 0.05 0.05
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0485 0.0538
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.1322 0.1322
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi Pre-SET motif family protein 0.0034 0.0555 0.1036
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.131 0.131
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Onchocerca volvulus 0.0014 0.011 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0047 0.0012
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0118 0.0211
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.1322 0.3869
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.05 0.0617
Echinococcus granulosus lamin dm0 0.003 0.0467 0.0467
Plasmodium vivax SET domain protein, putative 0.0034 0.0555 0.0462
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0236 0.0236
Brugia malayi Cytochrome P450 family protein 0.0029 0.0455 0.0834
Brugia malayi Cytochrome P450 family protein 0.0029 0.0455 0.0834
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0485 0.0896
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.3357 1
Schistosoma mansoni cytochrome P450 0.002 0.0236 0.0236
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.05 0.0617
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Echinococcus multilocularis dnaJ subfamily B 0.0455 1 1
Plasmodium falciparum hexose transporter 0.0103 0.2097 0.2094
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Schistosoma mansoni coup transcription factor 0.0011 0.0047 0.0047
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.1322 0.1322
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.1262 0.1262
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0118 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0047 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0236 0.0364
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.06 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3515 0.3595
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0555 0.0707
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0118 0.024
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0227 0.0227
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.05 0.0404
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0254 0.5492 0.5492
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0236 0.0364
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.131 0.383
Onchocerca volvulus 0.0066 0.127 0.2157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0047 0.0067
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0236 0.2574
Leishmania major hypothetical protein, conserved 0.0017 0.0186 0.0626
Schistosoma mansoni loxhd1 0.0066 0.127 0.127
Plasmodium vivax multidomain scavenger receptor, putative 0.0066 0.127 0.1219
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0047 0.0047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0047 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi Cytochrome P450 family protein 0.0062 0.1188 0.2312
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3515 0.5495
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.131 0.131
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0236 0.0364
Onchocerca volvulus Putative transporter 0.0014 0.0118 0.0126
Echinococcus multilocularis musashi 0.003 0.0467 0.0467
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0236 0.104
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0118 0.0169
Echinococcus multilocularis 0.002 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0236 0.0595
Loa Loa (eye worm) cytochrome P450 0.002 0.0236 0.0447
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0047 0.0047
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0236 0.0595
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0236 0.0595
Brugia malayi PAS domain containing protein 0.0054 0.1008 0.195
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0509 0.8107
Plasmodium vivax hexose transporter 0.0103 0.2097 0.2094
Trypanosoma brucei glucose transporter 2A 0.0032 0.0509 0.8107
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0424 0.64
Echinococcus granulosus lamin 0.003 0.0467 0.0467
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0118 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Leishmania major cytochrome p450-like protein 0.0029 0.0455 0.2843
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0509 0.0571
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0236 0.0364
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0512 0.0512
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0485 0.0485
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.1303 0.1303
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.5003 1
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0186 0.0186
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0485 0.0946
Loa Loa (eye worm) sugar transporter 0.0103 0.2097 0.4176
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0424 0.0494
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0118 0.0169
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0047 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0424 0.0323
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Schistosoma mansoni lamin 0.003 0.0467 0.0467
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0118 0.0012
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0236 0.0595
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Brugia malayi hypothetical protein 0.004 0.0692 0.1313
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0236 0.0595
Brugia malayi bHLH-PAS transcription factor 0.004 0.0693 0.1314
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0047 0.0047
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.3357 1
Schistosoma mansoni lamin 0.003 0.0467 0.0467
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0245 0.0194
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0509 0.0571
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0456 0.0456
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.113 0.2237
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.131 0.9895
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.05 0.0404
Brugia malayi hypothetical protein 0.0014 0.0118 0.0156
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0509 0.8139
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.131 0.383
Toxoplasma gondii protein kinase, putative 0.029 0.63 1
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0236 0.0364
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.1322 0.1322
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0455 0.0885
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0555 0.0555
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0236 0.0595
Onchocerca volvulus 0.003 0.0467 0.0741
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0509 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.05 0.0975
Leishmania major hypothetical protein, conserved 0.0014 0.0118 0.0068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.05 0.0558
Loa Loa (eye worm) hypothetical protein 0.0066 0.127 0.252
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0455 0.0885
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0078 0.013
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0186 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0236 0.0364
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0236 0.0595
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0467 0.086
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.05 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0118 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0066 0.127 0.252
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0309 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0509 0.0571
Loa Loa (eye worm) hypothetical protein 0.0028 0.0424 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0047 0.0012
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.011 0.011
Brugia malayi major facilitator superfamily protein 0.0014 0.0118 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0236 0.0364
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0236 0.019
Plasmodium falciparum protein kinase 6 0.0436 0.9567 1
Brugia malayi MH2 domain containing protein 0.0133 0.2773 0.5507
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi ecdysteroid receptor 0.0011 0.0047 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni intermediate filament proteins 0.003 0.0467 0.0467
Leishmania major glucose transporter, lmgt2 0.0032 0.0509 0.3288
Echinococcus granulosus cpg binding protein 0.0034 0.0552 0.0552
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0118 0.0169
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0236 0.0595
Loa Loa (eye worm) hypothetical protein 0.0182 0.3867 0.7723
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0044 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0509 0.0571
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0047 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.131 0.383
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3515 0.3595
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0424 0.0323
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0555 0.0555
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0254 0.5492 0.5492
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0186 0.0186
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.05 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Onchocerca volvulus 0.0014 0.0118 0.0126
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0692 0.0692
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.127 0.127
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0186 0.0109
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0013 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0309 0.0592
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0485 0.0527
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0119 0.0119
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.3357 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.011 0.2647
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0309 0.0539
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0692 0.0692
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0236 0.0595
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0236 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.05 0.05
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0118 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Plasmodium falciparum protein kinase 7 0.029 0.63 0.6542
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0309 0.0284
Schistosoma mansoni cpg binding protein 0.0034 0.0552 0.0552
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0236 0.0364
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.2773 0.5532
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1303 0.2585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0047 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0236 0.0364
Brugia malayi jmjC domain containing protein 0.0067 0.1303 0.2543
Schistosoma mansoni polycystin 1-related 0.0066 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.003 0.0467 0.091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0186 0.0346
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni glucose transport protein 0.0103 0.2097 0.2097
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0236 0.0364
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0236 0.0595
Brugia malayi hypothetical protein 0.0018 0.0201 0.0322
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Onchocerca volvulus 0.0034 0.0555 0.0896
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.05 0.0617
Onchocerca volvulus 0.0014 0.0118 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0236 0.0364
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0346
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.011 0.011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.127 0.127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0047 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Brugia malayi hypothetical protein 0.0014 0.0118 0.0156
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0186 0.1404
Entamoeba histolytica protein kinase, putative 0.0031 0.05 0.0282
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0424 0.6338
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0186 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2097 0.3201
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0186 0.0186
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Brugia malayi Cam kinase protein 1 0.0031 0.05 0.0925
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.3551 0.709
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Brugia malayi Sugar transporter family protein 0.0014 0.0118 0.0156
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0456 0.0456
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0047 0.0012
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Echinococcus granulosus single minded 2 0.004 0.0693 0.0693
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0118 0.024
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.1262 0.1262
Onchocerca volvulus 0.0066 0.127 0.2157
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0186 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0236 0.0364
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0186 0.0186
Leishmania major cytochrome p450-like protein 0.002 0.0236 0.104
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0236 0.2574
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.118 0.1717
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Schistosoma mansoni glucose transport protein 0.0103 0.2097 0.2097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0047 0.0012
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0309 0.0309
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0309 0.1637
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Brugia malayi hypoxia-induced factor 1 0.0168 0.3551 0.7074
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.06 0.051
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0309 0.0309
Brugia malayi hypothetical protein 0.0182 0.3867 0.771
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0047 0.0047
Schistosoma mansoni rab6-interacting 0.0066 0.127 0.127
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.1303 0.1303
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0467 0.091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0047 0.0067
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Brugia malayi jmjC domain containing protein 0.0065 0.1262 0.2461
Brugia malayi hypothetical protein 0.0066 0.127 0.2478
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0047 0.0047
Brugia malayi major facilitator superfamily protein 0.0014 0.0118 0.0156

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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