Detailed information for compound 680763

Basic information

Technical information
  • TDR Targets ID: 680763
  • Name: 1-(4-chloro-2-methylphenyl)-4-(4-ethylpiperaz in-1-yl)pyrazolo[4,5-e]pyrimidine
  • MW: 356.853 | Formula: C18H21ClN6
  • H donors: 0 H acceptors: 3 LogP: 3.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1ncnc2c1cnn2c1ccc(cc1C)Cl
  • InChi: 1S/C18H21ClN6/c1-3-23-6-8-24(9-7-23)17-15-11-22-25(18(15)21-12-20-17)16-5-4-14(19)10-13(16)2/h4-5,10-12H,3,6-9H2,1-2H3
  • InChiKey: MTRKCSPJDKNMIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chloro-2-methyl-phenyl)-4-(4-ethylpiperazin-1-yl)pyrazolo[4,5-e]pyrimidine
  • 1-(4-chloro-2-methylphenyl)-4-(4-ethyl-1-piperazinyl)pyrazolo[4,5-e]pyrimidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0236 0.2574
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.118 0.1717
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0186 0.0186
Leishmania major cytochrome p450-like protein 0.002 0.0236 0.104
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0309 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0047 0.0012
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0309 0.0309
Schistosoma mansoni glucose transport protein 0.0103 0.2097 0.2097
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Echinococcus granulosus single minded 2 0.004 0.0693 0.0693
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0118 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0047 0.0012
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0236 0.0364
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0186 0.0186
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.1262 0.1262
Onchocerca volvulus 0.0066 0.127 0.2157
Brugia malayi hypothetical protein 0.0066 0.127 0.2478
Brugia malayi jmjC domain containing protein 0.0065 0.1262 0.2461
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0047 0.0067
Brugia malayi major facilitator superfamily protein 0.0014 0.0118 0.0156
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0047 0.0047
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.06 0.051
Brugia malayi hypoxia-induced factor 1 0.0168 0.3551 0.7074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0467 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.1303 0.1303
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Schistosoma mansoni rab6-interacting 0.0066 0.127 0.127
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0309 0.0309
Brugia malayi hypothetical protein 0.0182 0.3867 0.771
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0047 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Brugia malayi hypothetical protein 0.0018 0.0201 0.0322
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0236 0.0364
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0346
Onchocerca volvulus 0.0014 0.0118 0.0126
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.05 0.0617
Onchocerca volvulus 0.0034 0.0555 0.0896
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0236 0.0364
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0236 0.0595
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0236 0.0364
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0186 0.0346
Onchocerca volvulus 0.0014 0.0118 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0467 0.091
Schistosoma mansoni glucose transport protein 0.0103 0.2097 0.2097
Brugia malayi jmjC domain containing protein 0.0067 0.1303 0.2543
Schistosoma mansoni polycystin 1-related 0.0066 0.127 0.127
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2097 0.3201
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0186 0.0186
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0456 0.0456
Brugia malayi Sugar transporter family protein 0.0014 0.0118 0.0156
Brugia malayi Cam kinase protein 1 0.0031 0.05 0.0925
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.3551 0.709
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0186 0.1404
Brugia malayi hypothetical protein 0.0014 0.0118 0.0156
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0047 0.0012
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.011 0.011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.127 0.127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0186 0.0072
Entamoeba histolytica protein kinase, putative 0.0031 0.05 0.0282
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0424 0.6338
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.011 0.2647
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0309 0.0539
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0119 0.0119
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.3357 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0236 0.0595
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0692 0.0692
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0309 0.0592
Schistosoma mansoni hypothetical protein 0.0013 0.0077 0.0077
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0186 0.0109
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0047 0.0047
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.127 0.127
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0485 0.0527
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1303 0.2585
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.2773 0.5532
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0236 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0047 0.0067
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0118 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.05 0.05
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0236 0.0364
Schistosoma mansoni cpg binding protein 0.0034 0.0552 0.0552
Plasmodium falciparum protein kinase 7 0.029 0.63 0.6542
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0309 0.0284
Plasmodium falciparum protein kinase 6 0.0436 0.9567 1
Leishmania major glucose transporter, lmgt2 0.0032 0.0509 0.3288
Schistosoma mansoni intermediate filament proteins 0.003 0.0467 0.0467
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi MH2 domain containing protein 0.0133 0.2773 0.5507
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi ecdysteroid receptor 0.0011 0.0047 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.011 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0047 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0509 0.0571
Loa Loa (eye worm) hypothetical protein 0.0028 0.0424 0.0822
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0236 0.019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0236 0.0364
Brugia malayi major facilitator superfamily protein 0.0014 0.0118 0.0156
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.05 0.0404
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0186 0.0186
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0254 0.5492 0.5492
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0555 0.0555
Onchocerca volvulus 0.0014 0.0118 0.0126
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0555 0.0555
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0047 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0509 0.0571
Loa Loa (eye worm) hypothetical protein 0.0182 0.3867 0.7723
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0044 0.0061
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0236 0.0595
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0118 0.0169
Echinococcus granulosus cpg binding protein 0.0034 0.0552 0.0552
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0424 0.0323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.131 0.383
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3515 0.3595
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0509 0.0571
Onchocerca volvulus 0.003 0.0467 0.0741
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0555 0.0555
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0236 0.0595
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.1322 0.1322
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0455 0.0885
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0455 0.0885
Loa Loa (eye worm) hypothetical protein 0.0066 0.127 0.252
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.05 0.0558
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.05 0.0975
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0014 0.0118 0.0068
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.05 0.0404
Brugia malayi hypothetical protein 0.0014 0.0118 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0236 0.0364
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.131 0.383
Toxoplasma gondii protein kinase, putative 0.029 0.63 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0509 0.8139
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0118 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0066 0.127 0.252
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0309 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0078 0.013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0044
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0186 0.0186
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.05 0.0404
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0467 0.086
Onchocerca volvulus 0.0014 0.0118 0.0126
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0236 0.0595
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0236 0.0364
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0118 0.0169
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0424 0.0494
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Loa Loa (eye worm) sugar transporter 0.0103 0.2097 0.4176
Loa Loa (eye worm) hypothetical protein 0.0031 0.0485 0.0946
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Schistosoma mansoni lamin 0.003 0.0467 0.0467
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0424 0.0323
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0047 0.0012
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.1303 0.1303
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0485 0.0485
Leishmania major cytochrome p450-like protein 0.0029 0.0455 0.2843
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0509 0.0571
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0512 0.0512
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0236 0.0364
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.5003 1
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0186 0.0186
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0456 0.0456
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0509 0.0571
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Schistosoma mansoni lamin 0.003 0.0467 0.0467
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0245 0.0194
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.131 0.9895
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.113 0.2237
Brugia malayi bHLH-PAS transcription factor 0.004 0.0693 0.1314
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0236 0.0595
Brugia malayi hypothetical protein 0.004 0.0692 0.1313
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0118 0.0012
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0236 0.0595
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.3357 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0047 0.0047
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0047 0.0047
Plasmodium vivax multidomain scavenger receptor, putative 0.0066 0.127 0.1219
Leishmania major hypothetical protein, conserved 0.0017 0.0186 0.0626
Schistosoma mansoni loxhd1 0.0066 0.127 0.127
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0236 0.0364
Onchocerca volvulus Putative transporter 0.0014 0.0118 0.0126
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3515 0.5495
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.131 0.131
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.0062 0.1188 0.2312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.05 0.0404
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0118 0.024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0555 0.0707
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0227 0.0227
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3515 0.3595
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0236 0.2574
Onchocerca volvulus 0.0066 0.127 0.2157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0047 0.0067
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0254 0.5492 0.5492
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.131 0.383
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0236 0.0364
Brugia malayi PAS domain containing protein 0.0054 0.1008 0.195
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0509 0.8107
Plasmodium vivax hexose transporter 0.0103 0.2097 0.2094
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0236 0.0595
Loa Loa (eye worm) cytochrome P450 0.002 0.0236 0.0447
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0047 0.0047
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0236 0.0595
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0236 0.0595
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0118 0.0118
Echinococcus granulosus lamin 0.003 0.0467 0.0467
Trypanosoma brucei glucose transporter 2A 0.0032 0.0509 0.8107
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0424 0.64
Echinococcus multilocularis musashi 0.003 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0236 0.104
Echinococcus multilocularis 0.002 0.0236 0.0236
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0118 0.0169
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Onchocerca volvulus 0.0014 0.011 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0047 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.131 0.131
Echinococcus granulosus lamin dm0 0.003 0.0467 0.0467
Plasmodium vivax SET domain protein, putative 0.0034 0.0555 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.05 0.0617
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0118 0.0211
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.1322 0.3869
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0485 0.0538
Schistosoma mansoni protein kinase 0.0031 0.05 0.05
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.1322 0.1322
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0118 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0047 0.0012
Brugia malayi Pre-SET motif family protein 0.0034 0.0555 0.1036
Onchocerca volvulus 0.0014 0.0118 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.1262 0.1262
Schistosoma mansoni sugar transporter 0.0014 0.0118 0.0118
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.1322 0.1322
Schistosoma mansoni coup transcription factor 0.0011 0.0047 0.0047
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.06 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0236 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0047 0.0012
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0118 0.0012
Brugia malayi Cytochrome P450 family protein 0.0029 0.0455 0.0834
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0485 0.0896
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.3357 1
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0236 0.0236
Brugia malayi Cytochrome P450 family protein 0.0029 0.0455 0.0834
Plasmodium falciparum hexose transporter 0.0103 0.2097 0.2094
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2097 0.2097
Echinococcus multilocularis dnaJ subfamily B 0.0455 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.05 0.0617
Schistosoma mansoni cytochrome P450 0.002 0.0236 0.0236
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0485 0.0485
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0236 0.2446
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.06 0.404
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2097 0.2097
Brugia malayi CXXC zinc finger family protein 0.0032 0.0511 0.0948
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.05 0.7919
Leishmania major glucose transporter, lmgt3 0.0032 0.0509 0.3288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0555 0.0555
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0047 0.0047
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.1322 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0047 0.0047
Leishmania major glucose transporter, lmgt1 0.0032 0.0509 0.3288
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.05 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.127 0.127
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0309 0.0201
Brugia malayi nuclear receptor NHR-88 0.0011 0.0047 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Entamoeba histolytica protein kinase, putative 0.0031 0.05 0.0282
Brugia malayi hypothetical protein 0.0066 0.127 0.2478
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Onchocerca volvulus 0.0014 0.0118 0.0126
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0424 0.0323
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0509 0.8139
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0511 0.0998
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Loa Loa (eye worm) hypothetical protein 0.0031 0.05 0.0975
Loa Loa (eye worm) hypothetical protein 0.0034 0.0555 0.1086
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0485 0.0946
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0231 0.0373
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0485 0.0896
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni cpg binding protein 0.0032 0.0511 0.0511
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0236 0.0595
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0236 0.0364
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0047 0.0047
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.7087 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus intermediate filament protein 0.003 0.0467 0.0467
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.1322 0.3718
Mycobacterium leprae putative cytochrome p450 0.002 0.0236 0.0388
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0309 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0047 0.0067
Brugia malayi Pre-SET motif family protein 0.0232 0.5003 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.05 0.0404
Echinococcus multilocularis solute carrier family 22 0.0014 0.0118 0.0118
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0309 0.0201
Schistosoma mansoni hypothetical protein 0.0455 1 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Trypanosoma brucei glucose transporter 1E 0.0032 0.0509 0.8107
Leishmania major protein kinase, putative 0.0016 0.0154 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Schistosoma mansoni hypothetical protein 0.004 0.0692 0.0692
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0236 0.2574
Onchocerca volvulus 0.003 0.0467 0.0741
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0455 0.6986
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0231 0.0348
Echinococcus multilocularis lamin dm0 0.003 0.0467 0.0467
Schistosoma mansoni lipoxygenase 0.0136 0.2836 0.2836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0047 0.0067
Echinococcus granulosus General substrate transporter 0.0088 0.1773 0.1773
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0693 0.0693
Onchocerca volvulus 0.0014 0.0118 0.0126
Loa Loa (eye worm) STAT protein 0.0161 0.3399 0.6785
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0424 0.64
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0231 0.0348
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0509 0.8107
Onchocerca volvulus 0.0014 0.0118 0.0126
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0186 0.0186
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0509 0.8139
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0047 0.0012
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2097 0.2848
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 0.9567 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0119 0.0213
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0346
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0047 0.0047
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0455 0.7037
Plasmodium falciparum proline--tRNA ligase 0.0036 0.06 0.051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.1322 0.2582
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0119 0.0119
Brugia malayi hypothetical protein 0.0028 0.0424 0.0771
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0118 0.0118
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0309 0.395
Leishmania major cytochrome p450-like protein 0.002 0.0236 0.104
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0047 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0047 0.0047
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0227 0.0227
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0118 0.0156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.1303 0.1303
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0236 0.0364
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0236 0.0364
Brugia malayi nuclear hormone receptor 0.0011 0.0047 0.0012
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0118 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0555 0.0555
Schistosoma mansoni glucose transporter 0.0014 0.0118 0.0118
Onchocerca volvulus 0.0014 0.0118 0.0126
Brugia malayi Cytochrome P450 family protein 0.002 0.0236 0.0393
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.131 0.1927
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus phd:f box containing protein 0.0017 0.0186 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0047 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0118 0.024
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0077 0.0077
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0236 0.0595
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.05 0.0975
Brugia malayi jmjC domain containing protein 0.0017 0.0186 0.0292
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0186 0.0186
Leishmania major protein kinase, putative 0.0016 0.0154 0.0363
Leishmania major protein kinase, putative 0.0031 0.05 0.3214
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0236 0.0595
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0509 0.0571
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0047 0.0047
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0509 0.3288
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.127 0.127
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0236 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Brugia malayi Sugar transporter family protein 0.0103 0.2097 0.4144
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0236 0.0595
Mycobacterium ulcerans sugar transporter 0.0014 0.0118 0.024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.011 0.011
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.011 0.011
Brugia malayi hypothetical protein 0.0014 0.0118 0.0156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0047 0.0047
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0186 0.1549
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0047 0.0047
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.05 0.0404
Echinococcus multilocularis cpg binding protein 0.0034 0.0552 0.0552
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0014 0.0107 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0509 0.8107
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0236 0.0595
Echinococcus multilocularis RUN 0.0066 0.127 0.127
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0047 0.0012
Brugia malayi Doublecortin family protein 0.0066 0.127 0.2478
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0118 0.5
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.05 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.06 1
Schistosoma mansoni jumonji domain containing protein 0.0065 0.1262 0.1262
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0047 0.0047
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0186 0.0186
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.011 0.0194
Echinococcus multilocularis Polycystic kidney disease protein 0.0066 0.127 0.127
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0047 0.0047
Onchocerca volvulus 0.0014 0.0118 0.0126
Onchocerca volvulus 0.004 0.0693 0.1139
Entamoeba histolytica hypothetical protein 0.004 0.0692 0.0566
Onchocerca volvulus 0.0014 0.0118 0.0126
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0236 0.0595
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Schistosoma mansoni rab6-interacting 0.0066 0.127 0.127
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.06 0.404
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0309 0.0309
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0236 0.0595
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0485 0.0261
Loa Loa (eye worm) hypothetical protein 0.0014 0.0107 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0047 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0047 0.0047
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0455 0.7037
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0118 0.0156
Mycobacterium ulcerans putative regulatory protein 0.004 0.0693 0.1972
Echinococcus multilocularis lamin 0.003 0.0467 0.0467
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.06 0.0779
Schistosoma mansoni cpg binding protein 0.0034 0.0552 0.0552
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Schistosoma mansoni protein kinase 0.0031 0.05 0.05
Schistosoma mansoni glucose transport protein 0.0103 0.2097 0.2097
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.1188 0.2355
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0236 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0509 0.0571
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Schistosoma mansoni hypothetical protein 0.0103 0.2097 0.2097
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0185 0.1529
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0309 0.0308
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0485 0.0485
Schistosoma mansoni single-minded 0.0054 0.1008 0.1008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0047 0.0012
Schistosoma mansoni protein kinase 0.0031 0.05 0.05
Echinococcus multilocularis General substrate transporter 0.0088 0.1773 0.1773
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0309 0.0273
Leishmania major hypothetical protein, conserved 0.0028 0.0424 0.2586
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0186 0.0186
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.05 0.05
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0455 0.0885
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0047 0.0067
Echinococcus granulosus solute carrier family 22 0.0014 0.0118 0.0118
Brugia malayi Sugar transporter family protein 0.0014 0.0118 0.0156
Plasmodium falciparum LCCL domain-containing protein 0.0066 0.127 0.1219
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Echinococcus granulosus Polycystic kidney disease protein 0.0066 0.127 0.127
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.131 0.3678
Onchocerca volvulus 0.0032 0.0511 0.0819
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.002 0.0236 0.0236
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0485 0.0485
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Loa Loa (eye worm) doublecortin family protein 0.0066 0.127 0.252
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0077 0.0077
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0186 0.0109
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0309 0.0309
Schistosoma mansoni lipoxygenase 0.0254 0.5492 0.5492
Trichomonas vaginalis set domain proteins, putative 0.0264 0.572 0.8041
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0236 0.0364
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0186 0.0346
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0186 0.1549
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0692 0.0692
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.1262 0.1262
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0047 0.0012
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0309 0.0813
Trypanosoma brucei glucose transporter, putative 0.0032 0.0509 0.8107
Onchocerca volvulus 0.0014 0.0118 0.0126
Loa Loa (eye worm) hypothetical protein 0.0029 0.0455 0.0886
Schistosoma mansoni hypothetical protein 0.0066 0.127 0.127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0047 0.0047
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0236 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0047 0.0012
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.7087 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.1322 0.3869
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.1008 0.1008
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.05 0.0925
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0555 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0047 0.0012
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0309 0.4052
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0155 0.0284
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.06 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.7087 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0154 0.0899
Plasmodium vivax JmjC domain containing protein 0.0017 0.0186 0.0072
Brugia malayi intermediate filament protein 0.003 0.0467 0.086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0118 0.0211
Echinococcus granulosus RUN 0.0066 0.127 0.127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1342 0.1342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0047 0.0012
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0186 0.0186
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.7087 1
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0236 0.0388
Brugia malayi steroid hormone receptor 0.0011 0.0047 0.0012
Loa Loa (eye worm) intermediate filament protein 0.003 0.0467 0.091
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0155 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0356 0.0687
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.05 0.0404
Brugia malayi STAT protein, DNA binding domain containing protein 0.0161 0.3399 0.6767
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0186 0.0346
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Trypanosoma cruzi hexose transporter 0.0032 0.0509 0.8139
Loa Loa (eye worm) sugar transporter 0.0014 0.0118 0.0211
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0455 0.1254
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0118 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0118 0.0012
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0236 0.0595
Onchocerca volvulus 0.0264 0.572 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.7087 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0236 0.0595
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.131 0.131
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.2773 0.5532
Brugia malayi cytochrome P450 0.002 0.0236 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0236 0.0364
Onchocerca volvulus 0.0014 0.0118 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0118 0.0012
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0485 0.1156

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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