Detailed information for compound 715999

Basic information

Technical information
  • TDR Targets ID: 715999
  • Name: N-[2-(4-acetylpiperazin-1-yl)phenyl]-3,4,5-tr imethoxybenzamide
  • MW: 413.467 | Formula: C22H27N3O5
  • H donors: 1 H acceptors: 2 LogP: 2.06 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)Nc1ccccc1N1CCN(CC1)C(=O)C
  • InChi: 1S/C22H27N3O5/c1-15(26)24-9-11-25(12-10-24)18-8-6-5-7-17(18)23-22(27)16-13-19(28-2)21(30-4)20(14-16)29-3/h5-8,13-14H,9-12H2,1-4H3,(H,23,27)
  • InChiKey: DMSLFFXHLKSCOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-acetylpiperazin-1-yl)phenyl]-3,4,5-trimethoxy-benzamide
  • N-[2-(4-acetyl-1-piperazinyl)phenyl]-3,4,5-trimethoxybenzamide
  • N-[2-(4-ethanoylpiperazin-1-yl)phenyl]-3,4,5-trimethoxy-benzamide
  • ZINC04810744
  • STOCK5S-35684

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.003 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0013 0.0472
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0056
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0296 0.2053
Trypanosoma cruzi trypanothione reductase, putative 0.0269 0.0393 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0152 0.0212 0.0674
Giardia lamblia Glutamate synthase 0.0025 0.0013 0.0861
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0143 0.0197 0.0197
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0269 0.0393 0.1257
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0013 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0085 0.2495
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0162 0.4125
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0003 0.0091
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0057 0.1442
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0025 0.0075
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 1
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0063 0.1598
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0393
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0085 0.303
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0007 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.003 0.003
Mycobacterium ulcerans beta-lactamase 0.0041 0.0039 0.0121
Brugia malayi Latrophilin receptor protein 2 0.005 0.0053 0.0364
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.003 0.003
Brugia malayi Pre-SET motif family protein 0.0207 0.0296 0.2053
Mycobacterium ulcerans hypothetical protein 0.007 0.0085 0.0266
Mycobacterium ulcerans monoxygenase 0.0025 0.0013 0.0038
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0007 0.0175
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0023 0.0023
Schistosoma mansoni ferritin 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0057 0.1665
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0039 0.0121
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0013 0.0038
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0 0.0001
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0013 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.003 0.021
Leishmania major NADH dehydrogenase, putative 0.0025 0.0013 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.003 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0085 0.2148
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0039 0.1145
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.003 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.003 0.0812
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0085 0.0266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.003 0.021
Giardia lamblia GTOR 0.0089 0.0114 0.9469
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0007 0.0152
Schistosoma mansoni hypothetical protein 0.005 0.0053 0.0053
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0755
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0089 0.0114 0.0114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.003 0.003
Brugia malayi nuclear receptor RXR 0.0021 0.0008 0.0056
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0007 0.0175
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0093 0.012 0.0379
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.003 0.003
Plasmodium falciparum thioredoxin reductase 0.0269 0.0393 1
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1452
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1452
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.012 0.3044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0031 0.0896
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0162 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0089 0.0114 0.4073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0085 0.0267
Echinococcus granulosus GPCR family 2 0.005 0.0053 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0105 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.003 0.021
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0013 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0058 0.1689
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0013 0.0335
Schistosoma mansoni hypothetical protein 0.005 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0271
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0032 0.0801
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0039 0.0121
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0013 0.0472
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0013 0.0861
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0018 0.0003 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.003 0.003
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0013 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.0197 0.0197
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0007 0.0202
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0013 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0013 0.0335
Echinococcus granulosus expressed protein 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0007 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0162 0.4125
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1452
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0089 0.0114 0.2887
Entamoeba histolytica hypothetical protein 0.0143 0.0197 0.7084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0027
Schistosoma mansoni ferritin 0.0017 0.0001 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.027 0.0395 0.0395
Brugia malayi hypothetical protein 0.0021 0.0008 0.0056
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0013 0.0013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0093 0.012 0.3044
Schistosoma mansoni glutamate synthase 0.0025 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0093 0.012 0.5627
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0067 0.0067
Onchocerca volvulus 0.0027 0.0017 0.0441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.003 0.021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.003 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1455
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0117 0.0156 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0039 0.0994
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0007 0.0018
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0013 0.0013
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1608 0.2476 0.2476
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0021 0.054
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.003 0.021
Brugia malayi ecdysteroid receptor 0.0036 0.003 0.021
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0023 0.0023
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0013 0.0312
Toxoplasma gondii exonuclease III APE 0.0018 0.0003 0.0079
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0085 0.2495
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0039 0.0121
Brugia malayi hypothetical protein 0.0021 0.0008 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0039 0.1145
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0013 0.0472
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0003 0.0079
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0093 0.012 0.3044
Onchocerca volvulus 0.0021 0.0007 0.0186
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Mycobacterium tuberculosis Probable dehydrogenase 0.0613 0.0929 0.2977
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0013 0.0335
Onchocerca volvulus 0.007 0.0085 0.2272
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0013 0.0386
Schistosoma mansoni patched 1 0.0084 0.0105 0.0105
Onchocerca volvulus 0.0036 0.003 0.0812
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0013 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0143 0.0989
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0025 0.0013 0.0335
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0021 0.054
Echinococcus multilocularis protein patched 0.0084 0.0105 0.0105
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0013 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0172 0.0172
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0013 0.0038
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0039 0.0039
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0056 0.1433
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Plasmodium falciparum glutathione reductase 0.0093 0.012 0.3044
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0007 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0393
Echinococcus multilocularis lamin 0.0027 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0014 0.0363
Entamoeba histolytica hypothetical protein 0.0017 0.0001 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0039 0.1145
Trypanosoma brucei trypanothione reductase 0.0269 0.0393 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0001 0.0001
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0152 0.0212 0.0212
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0013 0.0472
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0007 0.0175
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0093 0.012 0.3044
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0161
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0085 0.303
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.0409 0.0409
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0007 0.0018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0008 0.0008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0085 0.0266
Schistosoma mansoni hypothetical protein 0.0108 0.0143 0.0143
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0013 0.0335
Brugia malayi steroid hormone receptor 0.0036 0.003 0.021
Echinococcus multilocularis geminin 0.0171 0.0241 0.0241
Loa Loa (eye worm) inositol-1 0.0036 0.0031 0.0212
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0071 0.1811
Schistosoma mansoni ap endonuclease 0.0018 0.0003 0.0003
Plasmodium falciparum thioredoxin reductase 0.0093 0.012 0.3044
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0279 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0255 0.0371 0.2572
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0052 0.0056 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0021 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.01 0.013 0.0413
Schistosoma mansoni inositol monophosphatase 0.0036 0.0031 0.0031
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0013 0.0386
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0031 0.1096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0007 0.0175
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0171 0.0241 0.0241
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0039 0.0121
Schistosoma mansoni hypothetical protein 0.0081 0.01 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Echinococcus multilocularis glutamate synthase 0.0025 0.0013 0.0013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0001 0.0023
Brugia malayi Inositol-1 0.0036 0.0031 0.0212
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0025 0.0013 0.0038
Echinococcus multilocularis protein dispatched 1 0.0096 0.0124 0.0124
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0001 0.0001
Echinococcus multilocularis ferritin 0.0017 0.0001 0.0001
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0023 0.0023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0067 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0228 0.0228
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0089 0.0114 0.0114
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0089 0.0114 0.0114
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0025 0.0013 0.0038
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0013 0.0038
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0013 0.0013
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2019 0.3116 1
Giardia lamblia Thioredoxin reductase 0.0025 0.0013 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0039 0.0994
Echinococcus multilocularis GPCR, family 2 0.005 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0114
Echinococcus granulosus lamin 0.0027 0.0017 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0085 0.0266
Brugia malayi Probable ClpP-like protease 0.0152 0.0212 0.1466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.003 0.021
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0007 0.0018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0021 0.054
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0093 0.012 0.3044
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0067 0.0067
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0013 0.0335
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0013 0.0092
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0007 0.0049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0172 0.1191
Brugia malayi hypothetical protein 0.0025 0.0014 0.01
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0007 0.0018
Brugia malayi beta-lactamase 0.0041 0.0039 0.0271
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.0283 0.0283
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0013 0.0312
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0279 0.0279
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0089 0.0114 0.4073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0027
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.0056 0.1433
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0023 0.0565
Loa Loa (eye worm) hypothetical protein 0.0108 0.0143 0.0989
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0013 0.0335
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0008 0.0008
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0173 0.0173
Schistosoma mansoni jumonji domain containing protein 0.0117 0.0156 0.0156
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0007 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.003 0.021
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0021 0.053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0007 0.0049
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0093 0.012 0.3044
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0193 0.0275 0.1901
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0013 0.0335
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0023 0.0587
Schistosoma mansoni glutamate synthase 0.0025 0.0013 0.0013
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0013 0.0038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0031 0.0777
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.0197 0.0197
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0021 0.0518
Schistosoma mansoni coup transcription factor 0.0036 0.003 0.003
Trichomonas vaginalis ferritin, putative 0.0017 0.0001 0.0036
Brugia malayi intermediate filament protein 0.0027 0.0017 0.0114
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0023 0.0023
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.003 0.0812
Schistosoma mansoni lamin 0.0027 0.0017 0.0017
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0071 0.0085 0.2167
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0039 0.0972
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0003 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0053 0.0053
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0013 0.0335
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Leishmania major cathepsin L-like protease 0.0062 0.0071 0.1811
Loa Loa (eye worm) glutathione reductase 0.0269 0.0393 0.2721
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.0344 0.2382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0085 0.2495
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0057 0.1442
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0013 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0007 0.0018
Mycobacterium ulcerans transcriptional regulator 0.2023 0.3122 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0089 0.0114 0.287
Brugia malayi glutathione reductase 0.0269 0.0393 0.2721
Onchocerca volvulus 0.0193 0.0275 0.739
Brugia malayi hypothetical protein 0.0016 0 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0093 0.012 0.5627
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0023 0.0023
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0161
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0013 0.0567
Onchocerca volvulus 0.0021 0.0007 0.0186
Echinococcus granulosus expressed conserved protein 0.0183 0.026 0.026
Echinococcus granulosus survival motor neuron protein 1 0.0944 0.1444 0.1444
Schistosoma mansoni ferritin light chain 0.0017 0.0001 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0777
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0052 0.0164
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0777
Toxoplasma gondii ABC1 family protein 0.0041 0.0039 0.0994
Brugia malayi hypothetical protein 0.0143 0.0197 0.1367
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0114 0.0786
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0007 0.0175
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.003 0.021
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.003 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.003 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0021 0.0622
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0117 0.0156 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.003 0.021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0114 0.0786
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0162 0.0162
Brugia malayi MH2 domain containing protein 0.0237 0.0344 0.2382
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0014 0.0341
Schistosoma mansoni hypothetical protein 0.0081 0.01 0.01
Trichomonas vaginalis mercuric reductase, putative 0.0093 0.012 0.3509
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0105 0.0728
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0013 0.0038
Echinococcus granulosus lamin dm0 0.0027 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.0025 0.0013 0.0335
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0007 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.003 0.021
Brugia malayi TAR-binding protein 0.0127 0.0172 0.1191
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.0078 0.1982
Echinococcus granulosus lysine specific demethylase 5A 0.0117 0.0156 0.0156
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0023 0.0587
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0007 0.0018
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0013 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0114 0.3328
Loa Loa (eye worm) hypothetical protein 0.007 0.0085 0.0585
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0068 0.0081 0.0563
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0161
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0117 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0271
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0161
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0025 0.0013 0.0567
Plasmodium vivax JmjC domain containing protein 0.0031 0.0023 0.0587
Brugia malayi Papain family cysteine protease containing protein 0.0016 0 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0003 0.0092
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0172 0.0172
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0067 0.1712
Onchocerca volvulus 0.0025 0.0013 0.0354
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0013 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0052 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0114 0.3328
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.003 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Loa Loa (eye worm) fibroinase 0.0016 0 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0013 0.0386
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0008 0.0008
Schistosoma mansoni ferritin 0.0017 0.0001 0.0001
Plasmodium vivax glutathione reductase, putative 0.0269 0.0393 1
Echinococcus granulosus glutamate synthase 0.0025 0.0013 0.0013
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 1
Brugia malayi Pre-SET motif family protein 0.003 0.0021 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1455
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0023 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0057 0.0178
Brugia malayi jmjC domain containing protein 0.0117 0.0156 0.1082
Echinococcus granulosus ferritin 0.0017 0.0001 0.0001
Onchocerca volvulus 0.0028 0.0019 0.05
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0093 0.012 0.3028
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.003 0.021
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0013 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0031 0.0023 0.0587
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.007 0.0085 0.0585
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0007 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0085 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.003 0.021
Echinococcus multilocularis peptidase Clp (S14 family) 0.01 0.013 0.013
Echinococcus granulosus geminin 0.0171 0.0241 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.003 0.003
Echinococcus multilocularis expressed protein 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0613 0.0929 0.2977
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0039 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.003 0.021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0085 0.0266
Brugia malayi CHE-14 protein 0.0084 0.0105 0.0728
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0013 0.0335
Schistosoma mansoni glutamate synthase 0.0025 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1455
Loa Loa (eye worm) hypothetical protein 0.007 0.0085 0.0585
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Entamoeba histolytica hypothetical protein 0.0143 0.0197 0.7084
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0003 0.0023
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0013 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0115
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0093 0.012 0.0829
Entamoeba histolytica hypothetical protein 0.0143 0.0197 0.7084
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0089 0.0114 0.2887
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.003 0.003
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0023 0.0023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0019 0.0019
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0031 0.0031
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0013 0.0013
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0271
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0025 0.0013 0.0335
Schistosoma mansoni hypothetical protein 0.005 0.0053 0.0053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0013 0.0386
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0093 0.012 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0093 0.012 0.3028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.003 0.021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.003 0.0812
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0023 0.0161
Mycobacterium tuberculosis Probable reductase 0.0613 0.0929 0.2977
Mycobacterium ulcerans lipase LipD 0.0041 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0071 0.1811
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0039 0.1145
Loa Loa (eye worm) hypothetical protein 0.0944 0.1444 1
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0158 0.0221 0.1528
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.0221 0.1528
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0057 0.2192
Loa Loa (eye worm) cysteine protease 0.0016 0 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0613 0.0929 0.2977
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0212 0.5386
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.0386 0.1235
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 0.0674
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0007 0.0018
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0007 0.0175
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0162 0.0162
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0053 0.0364
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0089 0.0114 0.2887
Mycobacterium tuberculosis Conserved protein 0.0041 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.007 0.0085 0.0585
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0003 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0162 0.0515
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0393
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0093 0.012 0.038
Loa Loa (eye worm) hypothetical protein 0.0152 0.0212 0.1466
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0013 0.0038
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0093 0.012 0.5364
Brugia malayi nuclear hormone receptor 0.0036 0.003 0.021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0093 0.012 0.012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0093 0.012 0.3044
Echinococcus granulosus intermediate filament protein 0.0027 0.0017 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0093 0.012 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0058 0.1689
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0013 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0085 0.0266
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0085 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0021 0.0622
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0172 0.0172
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0053 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0007 0.0049
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0056 0.0386
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0007 0.0018
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0013 0.0038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0003 0.0079
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.0156 0.1082
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0007 0.0018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0093 0.012 0.0379
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Mycobacterium ulcerans hypothetical protein 0.0025 0.0013 0.0038
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0013 0.0335
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0172 0.1191
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0007 0.0018
Brugia malayi AMP-binding enzyme family protein 0.007 0.0085 0.0585
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0013 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0013 0.0335
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0039 0.0271
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0031 0.0094
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2023 0.3122 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.003 0.021
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0152 0.0212 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0021 0.054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.003 0.003
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0007 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0049
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0013 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0021 0.0021
Entamoeba histolytica protein kinase rad3, putative 0.0017 0.0001 0.0033
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0007 0.0175
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0017 0.0114
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0023 0.0023
Schistosoma mansoni ferritin light chain 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0103 0.0135 0.0931
Treponema pallidum oxidoreductase 0.0025 0.0013 0.0567
Echinococcus multilocularis survival motor neuron protein 1 0.0944 0.1444 0.1444
Plasmodium vivax SET domain protein, putative 0.003 0.0021 0.053
Treponema pallidum NADH oxidase 0.0093 0.012 0.5627
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.003 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0014 0.0363
Schistosoma mansoni hypothetical protein 0.0193 0.0275 0.0275
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.01 0.013 0.0413
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0279 0.0279
Giardia lamblia NADH oxidase lateral transfer candidate 0.0093 0.012 1
Loa Loa (eye worm) ctsf protein 0.0016 0 0.0001
Schistosoma mansoni hypothetical protein 0.005 0.0053 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0021 0.0021
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0039 0.0121
Schistosoma mansoni apoferritin-2 0.0017 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0014 0.0363
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0021 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Trichomonas vaginalis esterase, putative 0.0041 0.0039 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0021 0.0622
Echinococcus multilocularis lysine specific demethylase 5A 0.0117 0.0156 0.0156
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0036 0.003 0.003
Mycobacterium ulcerans TetR family transcriptional regulator 0.2023 0.3122 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0071 0.0085 0.2149
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0161
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0001 0.0001
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2023 0.3122 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.021
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0013 0.0386
Brugia malayi Thioredoxin reductase 0.0269 0.0393 0.2721
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.003 0.021
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0013 0.0386
Echinococcus granulosus phd:f box containing protein 0.0031 0.0023 0.0023
Onchocerca volvulus 0.0021 0.0007 0.0186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0007 0.0018
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0031 0.0777
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0013 0.0567
Leishmania major hypothetical protein, conserved 0.0025 0.0014 0.0363
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0279 0.1929
Mycobacterium tuberculosis Conserved protein 0.0041 0.0039 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0052 0.0164
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0393
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.0197 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0195 0.0279 0.1929
Onchocerca volvulus 0.0041 0.0039 0.1051
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0023 0.0161
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0014 0.0363
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0013 0.0472
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0613 0.0929 0.2977
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Schistosoma mansoni hypothetical protein 0.0171 0.0241 0.0241
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.003 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0067 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0172 0.0172
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0613 0.0929 0.2977
Leishmania major hypothetical protein, conserved 0.0041 0.0039 0.0994
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0039 0.1145
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0013 0.0335
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0013 0.0312
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.003 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0021 0.0021
Toxoplasma gondii hypothetical protein 0.0052 0.0056 0.1433
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0003 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.0056
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0013 0.0335
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0681 0.1035 0.3318
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0007 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0105 0.3082
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0023 0.0587
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0021 0.0622
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0067 0.0467
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0068 0.1988
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0008 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0163 0.0228 0.0228
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.0409 0.0409
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0021 0.0021
Mycobacterium ulcerans dehydrogenase 0.0025 0.0013 0.0038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0093 0.012 0.0379
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0013 0.0038
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0023 0.0023
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0031 0.0896
Onchocerca volvulus 0.0235 0.0341 0.9178
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0007 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0007 0.0049
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0007 0.0018
Brugia malayi beta-lactamase family protein 0.0041 0.0039 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0092
Toxoplasma gondii thioredoxin reductase 0.0269 0.0393 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0007 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.003 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.003 0.021
Leishmania major hypothetical protein, conserved 0.0025 0.0013 0.0335
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0013 0.0092
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0007 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0085 0.2495
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0014 0.0363
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.01 0.013 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0053 0.0053
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0114 0.3328
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.012 0.3044
Brugia malayi beta-lactamase family protein 0.0041 0.0039 0.0271
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0105 0.0105
Brugia malayi nuclear receptor NHR-88 0.0036 0.003 0.021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.003 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 0.0674
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0068 0.0081 0.0563
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0071 0.1811
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0013 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.0221 0.1528
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0031 0.1394
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0023 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0341 1
Treponema pallidum thioredoxin reductase (trxB) 0.0025 0.0013 0.0567
Mycobacterium tuberculosis Conserved protein 0.0041 0.0039 0.0121
Echinococcus multilocularis microtubule associated protein 2 0.6444 1 1
Toxoplasma gondii FATC domain-containing protein 0.0017 0.0001 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0003 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.003 0.021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0013 0.0386
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0013 0.0386
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0031 0.0031
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0013 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0021 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0057 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0085 0.2495
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0093 0.012 0.3044
Onchocerca volvulus 0.0041 0.0039 0.1051
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0085 0.2148
Brugia malayi hypothetical protein 0.0944 0.1444 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0017 0.0001 0.0033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0681 0.1035 0.3312
Loa Loa (eye worm) RNA binding protein 0.0127 0.0172 0.1191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0023 0.0587
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0007 0.0247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.003 0.021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0681 0.1035 0.3318
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0007 0.0018
Onchocerca volvulus 0.0255 0.0371 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0078 0.2285
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0162 0.0162
Schistosoma mansoni intermediate filament proteins 0.0027 0.0017 0.0017
Brugia malayi RNA binding protein 0.0127 0.0172 0.1191
Brugia malayi Cathepsin L-like precursor 0.0016 0 0.0001
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0065 0.19
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0053 0.0364
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0007 0.0202
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.004 0.1004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0039 0.0121
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0007 0.0152
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0021 0.0518
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0007 0.0175
Onchocerca volvulus 0.0027 0.0017 0.0441
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0014 0.0363
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0021 0.0148
Echinococcus multilocularis musashi 0.0027 0.0017 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0017 0.0114
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0013 0.0312
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0089 0.0114 0.2887
Onchocerca volvulus 0.003 0.0021 0.0561
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0145
Trypanosoma cruzi target of rapamycin kinase 3 0.0071 0.0085 0.2167
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0067 0.0067
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.0001 0.0023
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0039 0.0271
Schistosoma mansoni hypothetical protein 0.0025 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0007
Mycobacterium ulcerans hypothetical protein 0.0041 0.0039 0.0121
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0013 0.0335
Onchocerca volvulus 0.0041 0.0039 0.1051
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.005 0.1455
Leishmania major cathepsin L-like protease 0.0062 0.0071 0.1811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0007 0.0007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0039 0.0121
Schistosoma mansoni peptidase Clp (S14 family) 0.0152 0.0212 0.0212
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0003 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0172 0.1191
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0212 0.5386
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0162 0.0515
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0025 0.0013 0.0335
Schistosoma mansoni hypothetical protein 0.0081 0.01 0.01
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0023 0.0587
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.003 0.003
Leishmania major trypanothione reductase 0.0269 0.0393 1
Schistosoma mansoni cellular tumor antigen P53 0.0255 0.0371 0.0371
Echinococcus multilocularis lamin dm0 0.0027 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.005 0.0053 0.0364
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0039 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0013 0.0335
Mycobacterium leprae Probable lipase LipE 0.0041 0.0039 0.0121
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0008 0.0056
Brugia malayi glutamate synthase 0.0025 0.0013 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0003 0.0112
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0021 0.0021
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0013 0.0013
Echinococcus multilocularis expressed conserved protein 0.0183 0.026 0.026
Echinococcus granulosus FTZ F1 alpha 0.0036 0.003 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.0221 0.1528
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0025 0.0075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0003 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0031 0.0896
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0013 0.0386
Toxoplasma gondii NADPH-glutathione reductase 0.0093 0.012 0.3044
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.003 0.003
Loa Loa (eye worm) oxidoreductase 0.0021 0.0007 0.0049
Schistosoma mansoni microtubule-associated protein tau 0.6444 1 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0013 0.0038
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0017 0.0114
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0013 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0039 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.0344 0.2382
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0013 0.0092
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0613 0.0929 0.2971
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0023 0.0023
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0085 0.0266
Leishmania major cathepsin L-like protease 0.0062 0.0071 0.1811
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0003 0.0079
Schistosoma mansoni hypothetical protein 0.0127 0.0173 0.0173
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0003 0.0092
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0056 0.2619
Echinococcus granulosus peptidase Clp S14 family 0.01 0.013 0.013
Loa Loa (eye worm) beta-lactamase 0.0041 0.0039 0.0271
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0085 0.0267
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0271
Schistosoma mansoni hypothetical protein 0.0081 0.01 0.01
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0025 0.0013 0.0038
Schistosoma mansoni ferritin 0.0017 0.0001 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.003 0.003
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0013 0.0013
Brugia malayi jmjC domain containing protein 0.0117 0.0156 0.1082
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0023 0.0161
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0089 0.0114 0.287
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0007 0.0175
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0071 0.1811
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0085 0.303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.1792
Schistosoma mansoni lamin 0.0027 0.0017 0.0017
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0007 0.0175
Echinococcus multilocularis tumor protein p63 0.1742 0.2684 0.2684
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0004 0.01
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0093 0.2733
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0161
Echinococcus granulosus thioredoxin glutathione reductase 0.027 0.0395 0.0395
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0013 0.0386
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0013 0.0472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0052 0.0164
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0271
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.003 0.003
Trichomonas vaginalis glutathione reductase, putative 0.0093 0.012 0.3509
Brugia malayi AMP-binding enzyme family protein 0.007 0.0085 0.0585
Echinococcus granulosus tar DNA binding protein 0.0127 0.0172 0.0172
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0093 0.012 0.3044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0021 0.0148
Schistosoma mansoni apoferritin-2 0.0017 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0228 0.0228
Plasmodium vivax thioredoxin reductase, putative 0.0269 0.0393 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0028
Schistosoma mansoni survival motor neuron protein 0.0193 0.0275 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0012 0.0349
Loa Loa (eye worm) hypothetical protein 0.0084 0.0105 0.0728
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0003 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0085 0.0266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0093 0.012 0.3044
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0057 0.0178
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0143 0.0197 0.7084
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0152 0.0212 0.0212
Echinococcus granulosus tumor protein p63 0.1742 0.2684 0.2684
Mycobacterium tuberculosis Probable oxidoreductase 0.0681 0.1035 0.3318
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.003 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0093 0.012 0.3028
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0212 0.5386
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0013 0.0312
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0085 0.2148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0058 0.1689
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0105 0.0105
Plasmodium falciparum glutathione reductase 0.0269 0.0393 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0003 0.0091
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0023 0.0023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0093 0.012 0.3028
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0067 0.0212
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0162 0.0515
Toxoplasma gondii selenide, water dikinase 0.0025 0.0013 0.0335
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0013 0.0013
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0051 0.1285
Loa Loa (eye worm) thioredoxin reductase 0.0269 0.0393 0.2721
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0172 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0039 0.0994
Schistosoma mansoni jumonji/arid domain-containing protein 0.0117 0.0156 0.0156

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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