Detailed information for compound 728207

Basic information

Technical information
  • TDR Targets ID: 728207
  • Name: 2-[[5-(4-ethyl-5-methylthiophen-3-yl)-4-propa n-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • MW: 324.465 | Formula: C14H20N4OS2
  • H donors: 1 H acceptors: 3 LogP: 2.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(C)scc1c1nnc(n1C(C)C)SCC(=O)N
  • InChi: 1S/C14H20N4OS2/c1-5-10-9(4)20-6-11(10)13-16-17-14(18(13)8(2)3)21-7-12(15)19/h6,8H,5,7H2,1-4H3,(H2,15,19)
  • InChiKey: PMZPQKSEHXMKKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(4-ethyl-5-methyl-3-thienyl)-4-isopropyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • 2-[[5-(4-ethyl-5-methyl-3-thienyl)-4-isopropyl-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(4-ethyl-5-methyl-thiophen-3-yl)-4-propan-2-yl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • IVK/1102893
  • ZINC06727208

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0009 0.0017
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0065 0.0056
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0278 0.2264
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0151 0.0977 0.1725
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.082 0.1448
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0224 0.1502 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0077 0.0576
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0065 0.0056
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0073 0.0469
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0224 0.1502 1
Echinococcus granulosus intermediate filament protein 0.0027 0.009 0.008
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0059 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0129
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.009 0.0158
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0059 0.0317 0.0523
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0028 0.014
Brugia malayi PHD-finger family protein 0.0026 0.0083 0.0147
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0278 0.0378
Schistosoma mansoni smad 0.0017 0.0016 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.009 0.0158
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Echinococcus multilocularis ectonucleotide 0.0315 0.2148 0.2141
Loa Loa (eye worm) intermediate filament protein 0.0027 0.009 0.0158
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0009 0.0017
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0006
Echinococcus multilocularis tumor protein p63 0.1051 0.7412 0.741
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0022 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0024 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0024 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Brugia malayi beta-lactamase 0.0151 0.0977 0.1725
Echinococcus granulosus cathepsin l1 0.0018 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0136
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0478 0.0469
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0097 0.0266
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Schistosoma mansoni Smad4 0.0017 0.0016 0.0006
Onchocerca volvulus 0.0151 0.0977 0.1693
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Echinococcus granulosus Endonuclease G 0.0224 0.1502 0.1494
Echinococcus multilocularis tar DNA binding protein 0.0129 0.082 0.0811
Trypanosoma brucei endonuclease G, putative 0.0224 0.1502 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0073 0.0076
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0029 0.0051
Brugia malayi Smad1 0.0017 0.0016 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0253 0.0447
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0022 0.0012
Echinococcus multilocularis lamin 0.0027 0.009 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0017
Brugia malayi MH1 domain containing protein 0.0017 0.0016 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0009 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0374 0.2435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0016 0.0028
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0016 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0977 0.6482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0977 0.0969
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0261 0.0252
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0022 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0059 0.0317 0.6467
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0442
Loa Loa (eye worm) hypothetical protein 0.0089 0.0535 0.0944
Echinococcus granulosus transferase 0.0059 0.0317 0.0308
Echinococcus multilocularis transferase 0.0059 0.0317 0.0308
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0152
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0059 0.0317 0.0559
Schistosoma mansoni zinc finger protein 0.0016 0.0011 0.0002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0028 0.0011
Mycobacterium ulcerans hypothetical protein 0.0059 0.0317 0.304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0039
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Brugia malayi Bromodomain containing protein 0.0078 0.0458 0.0808
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0478 0.0469
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.082 0.1448
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Leishmania major endonuclease G, putative 0.0224 0.1502 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0022 0.0039
Leishmania major hypothetical protein, conserved 0.0151 0.0977 0.6482
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0129
Brugia malayi beta-lactamase family protein 0.0151 0.0977 0.1725
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0059 0.0317 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0151 0.0977 0.141
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0024 0.0015
Brugia malayi hypothetical protein 0.0089 0.0535 0.0944
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0158
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0151 0.0977 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.0414
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0059 0.0317 1
Leishmania major cathepsin L-like protease 0.0067 0.0374 0.2435
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1647 0.2908
Mycobacterium ulcerans hypothetical protein 0.0025 0.0073 0.0469
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0253 0.0447
Loa Loa (eye worm) cysteine protease 0.0018 0.0022 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0129
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0059 0.0317 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0374 0.2435
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0164 0.0961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0261 0.0252
Loa Loa (eye worm) hypothetical protein 0.0374 0.2569 0.4535
Schistosoma mansoni lamin 0.0027 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0081 0.0478 0.0844
Echinococcus granulosus tumor protein p63 0.1051 0.7412 0.741
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0966 0.6802 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0028 0.0067
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0059 0.0317 0.0308
Brugia malayi TAR-binding protein 0.0129 0.082 0.1448
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0065 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0469
Loa Loa (eye worm) hypothetical protein 0.0374 0.2569 0.4535
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Echinococcus multilocularis Endonuclease G 0.0224 0.1502 0.1494
Brugia malayi MH2 domain containing protein 0.0245 0.1647 0.2908
Echinococcus multilocularis cysteine protease 0.0018 0.0022 0.0012
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Loa Loa (eye worm) TAR-binding protein 0.0129 0.082 0.1448
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0224 0.1502 1
Loa Loa (eye worm) hypothetical protein 0.0374 0.2569 0.4535
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0059 0.0317 0.0308
Loa Loa (eye worm) hypothetical protein 0.004 0.0184 0.0324
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0022 0.0012
Schistosoma mansoni eyes absent homolog 0.0089 0.0535 0.0526
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0343 0.0334
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0022 0.0039
Echinococcus granulosus smad 0.0017 0.0016 0.0006
Onchocerca volvulus 0.0027 0.009 0.012
Brugia malayi hypothetical protein 0.0059 0.0317 0.0559
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Brugia malayi MH2 domain containing protein 0.0017 0.0016 0.0028
Mycobacterium tuberculosis Conserved protein 0.0151 0.0977 0.141
Brugia malayi intermediate filament protein 0.0027 0.009 0.0158
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0977 1
Onchocerca volvulus 0.0374 0.2569 0.4513
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0164 0.1488
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0077 0.0372
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0059 0.0317 0.0308
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0043
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0272 0.1749
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0136 0.017
Echinococcus granulosus ectonucleotide 0.0315 0.2148 0.2141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0164 0.1488
Brugia malayi hypothetical protein 0.0025 0.0077 0.0136
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0022 0.0039
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0478 0.4479
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0278 0.0268
Mycobacterium ulcerans beta-lactamase 0.0151 0.0977 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0016 0.0006
Schistosoma mansoni bromodomain containing protein 0.0066 0.037 0.0361
Schistosoma mansoni zinc finger protein 0.002 0.0043 0.0034
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0022 0.0012
Schistosoma mansoni hypothetical protein 0.0022 0.0051 0.0042
Mycobacterium ulcerans hypothetical protein 0.0151 0.0977 1
Schistosoma mansoni lamin 0.0027 0.009 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0374 0.2435
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0016 0.0006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0164 0.1488
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0252
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Mycobacterium ulcerans esterase/lipase LipP 0.0151 0.0977 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0136 0.0699
Mycobacterium tuberculosis Conserved protein 0.0151 0.0977 0.141
Trypanosoma brucei endonuclease G, putative 0.0224 0.1502 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0059 0.0317 0.0308
Brugia malayi MH2 domain containing protein 0.0017 0.0016 0.0028
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0022 0.0012
Mycobacterium tuberculosis Probable lipase LipD 0.0151 0.0977 0.141
Loa Loa (eye worm) hypothetical protein 0.005 0.0253 0.0447
Loa Loa (eye worm) hypothetical protein 0.0154 0.0997 0.1759
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0022 0.0073
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Loa Loa (eye worm) beta-lactamase 0.0151 0.0977 0.1725
Onchocerca volvulus 0.0151 0.0977 0.1693
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0022 0.0012
Schistosoma mansoni hypothetical protein 0.0807 0.5665 0.5661
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0073 0.1727
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0024 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Schistosoma mansoni inositol monophosphatase 0.0037 0.0164 0.0155
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0374 0.2569 0.4535
Mycobacterium leprae conserved hypothetical protein 0.0151 0.0977 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0016 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0374 0.2435
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0097 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0478 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0977 1
Brugia malayi Inositol-1 0.0037 0.0164 0.029
Brugia malayi Thrombospondin type 1 domain containing protein 0.0807 0.5665 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0059 0.0317 0.0523
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0151 0.0977 0.141
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0807 0.5665 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 0.4738
Echinococcus multilocularis zinc finger protein 0.002 0.0043 0.0034
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0051 0.009
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0343 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.0414
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0164 0.0155
Echinococcus granulosus beta LACTamase domain containing family member 0.0151 0.0977 0.0969
Loa Loa (eye worm) ctsf protein 0.0018 0.0022 0.0039
Leishmania major ethanolamine phosphotransferase, putative 0.0059 0.0317 0.2051
Schistosoma mansoni hypothetical protein 0.0034 0.014 0.0131
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0059 0.0317 0.0308
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Echinococcus multilocularis smad 0.0017 0.0016 0.0006
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0164 0.4821
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0059 0.0317 0.0523
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.5658 0.5654
Echinococcus granulosus tar DNA binding protein 0.0129 0.082 0.0811
Onchocerca volvulus 0.0027 0.009 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0073 0.1727
Brugia malayi Probable ClpP-like protease 0.0081 0.0478 0.0844
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Echinococcus granulosus Smad4 0.0017 0.0016 0.0006
Leishmania major cathepsin L-like protease 0.0067 0.0374 0.2435
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0252
Loa Loa (eye worm) hypothetical protein 0.0315 0.2148 0.3793
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0073 0.1727
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0315 0.2148 0.2141
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0469
Onchocerca volvulus 0.0807 0.5665 1
Trypanosoma cruzi endonuclease G, putative 0.0224 0.1502 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Trichomonas vaginalis esterase, putative 0.0151 0.0977 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0164 0.1431
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0022 0.0012
Echinococcus granulosus lamin 0.0027 0.009 0.008
Mycobacterium tuberculosis Conserved protein 0.0151 0.0977 0.141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0151 0.0977 0.1725
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0261 0.046
Echinococcus granulosus lamin dm0 0.0027 0.009 0.008
Trypanosoma cruzi endonuclease G, putative 0.0224 0.1502 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0059 0.0317 0.0523
Trypanosoma brucei hypothetical protein, conserved 0.0151 0.0977 0.6482
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0059 0.0317 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.1208
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0977 0.6482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0252
Onchocerca volvulus 0.0374 0.2569 0.4513
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Brugia malayi RNA binding protein 0.0129 0.082 0.1448
Brugia malayi MH1 domain containing protein 0.0017 0.0016 0.0028
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0059 0.0317 0.0523
Loa Loa (eye worm) inositol-1 0.0037 0.0164 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0977 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Schistosoma mansoni inositol monophosphatase 0.0037 0.0164 0.0155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0073 0.0076
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0478 0.4773
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0129
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0261 0.0252
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0016 0.0006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 0.4738
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Schistosoma mansoni cellular tumor antigen P53 0.0154 0.0997 0.0988
Brugia malayi beta-lactamase family protein 0.0151 0.0977 0.1725
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0166 0.0156
Brugia malayi hypothetical protein 0.0016 0.0013 0.0023
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0024 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0261 0.046
Loa Loa (eye worm) hypothetical protein 0.0034 0.014 0.0248
Brugia malayi AEL166Cp 0.0059 0.0317 0.0559
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0059 0.0317 0.2051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0151 0.0977 0.0969
Echinococcus multilocularis microtubule associated protein 2 0.1413 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0151 0.0977 0.141
Brugia malayi Bromodomain containing protein 0.004 0.0183 0.0323
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.0414
Schistosoma mansoni microtubule-associated protein tau 0.1413 1 1
Loa Loa (eye worm) fibroinase 0.0018 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Schistosoma mansoni intermediate filament proteins 0.0027 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0426 0.0752
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0442
Leishmania major cathepsin L-like protease 0.0067 0.0374 0.2435
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0478 0.3082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Brugia malayi hypothetical protein 0.0059 0.0317 0.0559
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0002
Toxoplasma gondii hypothetical protein 0.0028 0.0097 0.0507
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0073 0.0469
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0166 0.0156
Onchocerca volvulus 0.0025 0.0073 0.009
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0006
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0333 0.2157
Mycobacterium leprae hypothetical protein 0.0059 0.0317 0.2698
Mycobacterium ulcerans lipase LipD 0.0151 0.0977 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0024 0.0015
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0315 0.2148 0.2141
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Onchocerca volvulus 0.0154 0.0997 0.1727
Toxoplasma gondii ABC1 family protein 0.0151 0.0977 0.6456
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Trypanosoma brucei endonuclease G, putative 0.0224 0.1502 1
Echinococcus multilocularis Smad4 0.0017 0.0016 0.0006
Loa Loa (eye worm) RNA binding protein 0.0129 0.082 0.1448
Echinococcus multilocularis lamin dm0 0.0027 0.009 0.008
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0278 0.0268
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.1208
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0478 0.3082
Loa Loa (eye worm) hypothetical protein 0.0045 0.0216 0.0381
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0059 0.0317 0.0559
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0073 0.0469
Echinococcus granulosus zinc finger protein 0.002 0.0043 0.0034
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0059 0.0317 0.0308
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0469
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0253 0.0447
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0022 0.0012
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0097 0.1644
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0977 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0077 0.0442
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0024 0.0015
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0164 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0977 0.0969
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.014 0.0248
Onchocerca volvulus 0.0151 0.0977 0.1693
Echinococcus multilocularis cysteine protease 0.0018 0.0022 0.0012
Loa Loa (eye worm) Smad1 0.0017 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0201 0.0356
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Leishmania major hypothetical protein, conserved 0.0025 0.0077 0.0442
Loa Loa (eye worm) hypothetical protein 0.0089 0.0535 0.0944
Plasmodium vivax hypothetical protein, conserved 0.0151 0.0977 1
Mycobacterium tuberculosis Probable lipase LipE 0.0151 0.0977 0.141
Mycobacterium leprae Probable lipase LipE 0.0151 0.0977 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0073 0.0469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0261 0.0252
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0977 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0224 0.1502 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0151 0.0977 0.141
Schistosoma mansoni endonuclease related 0.0224 0.1502 0.1494
Echinococcus multilocularis musashi 0.0027 0.009 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1647 0.2908
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Brugia malayi endonuclease G, mitochondrial precursor 0.0224 0.1502 0.2651
Mycobacterium tuberculosis Probable hydrolase 0.0151 0.0977 0.141
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0278 0.0378

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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