Detailed information for compound 728207

Basic information

Technical information
  • TDR Targets ID: 728207
  • Name: 2-[[5-(4-ethyl-5-methylthiophen-3-yl)-4-propa n-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • MW: 324.465 | Formula: C14H20N4OS2
  • H donors: 1 H acceptors: 3 LogP: 2.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(C)scc1c1nnc(n1C(C)C)SCC(=O)N
  • InChi: 1S/C14H20N4OS2/c1-5-10-9(4)20-6-11(10)13-16-17-14(18(13)8(2)3)21-7-12(15)19/h6,8H,5,7H2,1-4H3,(H2,15,19)
  • InChiKey: PMZPQKSEHXMKKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(4-ethyl-5-methyl-3-thienyl)-4-isopropyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • 2-[[5-(4-ethyl-5-methyl-3-thienyl)-4-isopropyl-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(4-ethyl-5-methyl-thiophen-3-yl)-4-propan-2-yl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • IVK/1102893
  • ZINC06727208

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0024 0.0015
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0278 0.0268
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0073 0.1727
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0272 0.1749
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.5658 0.5654
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0343 0.0334
Echinococcus multilocularis smad 0.0017 0.0016 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0016 0.0006
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0022 0.0073
Echinococcus multilocularis Endonuclease G 0.0224 0.1502 0.1494
Leishmania major cathepsin L-like protease 0.0067 0.0374 0.2435
Onchocerca volvulus 0.0374 0.2569 0.4513
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Brugia malayi hypothetical protein 0.0059 0.0317 0.0559
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1647 0.2908
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0059 0.0317 0.0523
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0164 0.1488
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0022 0.0012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0478 0.3082
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0016 0.0028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0022 0.0012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0016 0.0006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0166 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0977 1
Echinococcus multilocularis zinc finger protein 0.002 0.0043 0.0034
Echinococcus granulosus tumor protein p63 0.1051 0.7412 0.741
Plasmodium vivax hypothetical protein, conserved 0.0151 0.0977 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0059 0.0317 0.0523
Schistosoma mansoni Smad4 0.0017 0.0016 0.0006
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0059 0.0317 0.0523
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0261 0.0252
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0022 0.0012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0158
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0073 0.1727
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0028 0.0011
Brugia malayi TAR-binding protein 0.0129 0.082 0.1448
Mycobacterium ulcerans hypothetical protein 0.0151 0.0977 1
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Schistosoma mansoni cellular tumor antigen P53 0.0154 0.0997 0.0988
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0065 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.0414
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0442
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0059 0.0317 0.0308
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0164 0.0155
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0151 0.0977 0.141
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0478 0.0469
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0278 0.2264
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0374 0.2435
Brugia malayi hypothetical protein 0.0059 0.0317 0.0559
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Onchocerca volvulus 0.0151 0.0977 0.1693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0039
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0022 0.0012
Brugia malayi hypothetical protein 0.0016 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0034 0.014 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0469
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0374 0.2435
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0059 0.0317 0.0308
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0059 0.0317 0.0308
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0977 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0278 0.0378
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0136 0.0699
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0343 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Echinococcus multilocularis lamin 0.0027 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0073 0.1727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Mycobacterium tuberculosis Probable esterase LipL 0.0151 0.0977 0.141
Echinococcus granulosus transferase 0.0059 0.0317 0.0308
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0059 0.0317 0.2051
Onchocerca volvulus 0.0151 0.0977 0.1693
Brugia malayi beta-lactamase family protein 0.0151 0.0977 0.1725
Schistosoma mansoni microtubule-associated protein tau 0.1413 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0017
Leishmania major ethanolamine phosphotransferase, putative 0.0059 0.0317 0.2051
Mycobacterium ulcerans lipase LipD 0.0151 0.0977 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Onchocerca volvulus 0.0807 0.5665 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0073 0.0469
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0478 0.0469
Brugia malayi Thrombospondin type 1 domain containing protein 0.0807 0.5665 1
Brugia malayi Bromodomain containing protein 0.0078 0.0458 0.0808
Schistosoma mansoni hypothetical protein 0.0034 0.014 0.0131
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0051 0.009
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0224 0.1502 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0077 0.0442
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Echinococcus multilocularis musashi 0.0027 0.009 0.008
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0201 0.0356
Leishmania major hypothetical protein, conserved 0.0151 0.0977 0.6482
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0028 0.0067
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0333 0.2157
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0151 0.0977 0.141
Loa Loa (eye worm) hypothetical protein 0.0374 0.2569 0.4535
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.0414
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0043
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0028 0.014
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.014 0.0248
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0152
Echinococcus granulosus Smad4 0.0017 0.0016 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0151 0.0977 0.141
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0065 0.0056
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0224 0.1502 1
Brugia malayi MH1 domain containing protein 0.0017 0.0016 0.0028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0097 0.0785
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0469
Echinococcus granulosus lamin 0.0027 0.009 0.008
Schistosoma mansoni lamin 0.0027 0.009 0.008
Schistosoma mansoni bromodomain containing protein 0.0066 0.037 0.0361
Schistosoma mansoni zinc finger protein 0.0016 0.0011 0.0002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0164 0.1431
Loa Loa (eye worm) hypothetical protein 0.0059 0.0317 0.0559
Schistosoma mansoni endonuclease related 0.0224 0.1502 0.1494
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0164 0.4821
Echinococcus granulosus zinc finger protein 0.002 0.0043 0.0034
Onchocerca volvulus 0.0025 0.0073 0.009
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0059 0.0317 1
Mycobacterium leprae hypothetical protein 0.0059 0.0317 0.2698
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0022 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0469
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Mycobacterium ulcerans hypothetical protein 0.0025 0.0073 0.0469
Trypanosoma brucei endonuclease G, putative 0.0224 0.1502 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0016 0.0006
Onchocerca volvulus 0.0151 0.0977 0.1693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0077 0.0576
Loa Loa (eye worm) TAR-binding protein 0.0129 0.082 0.1448
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0151 0.0977 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0024 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0253 0.0447
Brugia malayi AEL166Cp 0.0059 0.0317 0.0559
Echinococcus multilocularis Smad4 0.0017 0.0016 0.0006
Onchocerca volvulus 0.0154 0.0997 0.1727
Brugia malayi hypothetical protein 0.0025 0.0077 0.0136
Brugia malayi Probable ClpP-like protease 0.0081 0.0478 0.0844
Loa Loa (eye worm) Smad1 0.0017 0.0016 0.0028
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0024 0.0015
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0022 0.0012
Trypanosoma brucei endonuclease G, putative 0.0224 0.1502 1
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.082 0.1448
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0478 0.0469
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0151 0.0977 0.1725
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0022 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.1208
Brugia malayi endonuclease G, mitochondrial precursor 0.0224 0.1502 0.2651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0151 0.0977 0.1725
Echinococcus multilocularis cysteine protease 0.0018 0.0022 0.0012
Echinococcus granulosus lamin dm0 0.0027 0.009 0.008
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Echinococcus multilocularis cysteine protease 0.0018 0.0022 0.0012
Toxoplasma gondii hypothetical protein 0.0028 0.0097 0.0507
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0059 0.0317 1
Echinococcus granulosus intermediate filament protein 0.0027 0.009 0.008
Mycobacterium ulcerans hypothetical protein 0.0059 0.0317 0.304
Leishmania major endonuclease G, putative 0.0224 0.1502 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Mycobacterium tuberculosis Probable hydrolase 0.0151 0.0977 0.141
Trypanosoma brucei endonuclease G, putative 0.0224 0.1502 1
Echinococcus granulosus ectonucleotide 0.0315 0.2148 0.2141
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0073 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.1208
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0059 0.0317 0.0559
Echinococcus multilocularis ectonucleotide 0.0315 0.2148 0.2141
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0807 0.5665 1
Echinococcus multilocularis microtubule associated protein 2 0.1413 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0009 0.0017
Brugia malayi beta-lactamase 0.0151 0.0977 0.1725
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0164 0.0961
Toxoplasma gondii ABC1 family protein 0.0151 0.0977 0.6456
Brugia malayi intermediate filament protein 0.0027 0.009 0.0158
Loa Loa (eye worm) fibroinase 0.0018 0.0022 0.0039
Echinococcus multilocularis tumor protein p63 0.1051 0.7412 0.741
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0077 0.0372
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0253 0.0447
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Leishmania major cathepsin L-like protease 0.0067 0.0374 0.2435
Echinococcus granulosus smad 0.0017 0.0016 0.0006
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0315 0.2148 0.2141
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0224 0.1502 1
Trypanosoma cruzi endonuclease G, putative 0.0224 0.1502 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0016 0.0006
Echinococcus multilocularis transferase 0.0059 0.0317 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0252
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0374 0.2435
Loa Loa (eye worm) ctsf protein 0.0018 0.0022 0.0039
Schistosoma mansoni hypothetical protein 0.0022 0.0051 0.0042
Brugia malayi MH2 domain containing protein 0.0017 0.0016 0.0028
Schistosoma mansoni smad 0.0017 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0374 0.2569 0.4535
Echinococcus multilocularis tar DNA binding protein 0.0129 0.082 0.0811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Loa Loa (eye worm) RNA binding protein 0.0129 0.082 0.1448
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0442
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0129
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0278 0.0268
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0261 0.046
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0024 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Mycobacterium tuberculosis Conserved protein 0.0151 0.0977 0.141
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0022 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0261 0.0252
Echinococcus granulosus Endonuclease G 0.0224 0.1502 0.1494
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 0.4738
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0977 0.0969
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0151 0.0977 0.141
Loa Loa (eye worm) hypothetical protein 0.0089 0.0535 0.0944
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Loa Loa (eye worm) hypothetical protein 0.0315 0.2148 0.3793
Schistosoma mansoni inositol monophosphatase 0.0037 0.0164 0.0155
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Echinococcus granulosus tar DNA binding protein 0.0129 0.082 0.0811
Echinococcus multilocularis beta LACTamase domain containing family member 0.0151 0.0977 0.0969
Loa Loa (eye worm) intermediate filament protein 0.0027 0.009 0.0158
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.009 0.0158
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Onchocerca volvulus 0.0027 0.009 0.012
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0059 0.0317 0.0308
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0059 0.0317 0.0308
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Loa Loa (eye worm) inositol-1 0.0037 0.0164 0.029
Mycobacterium tuberculosis Probable lipase LipE 0.0151 0.0977 0.141
Schistosoma mansoni tar DNA-binding protein 0.0129 0.082 0.0811
Mycobacterium tuberculosis Conserved protein 0.0151 0.0977 0.141
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0009 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0129
Onchocerca volvulus 0.0027 0.009 0.012
Loa Loa (eye worm) cysteine protease 0.0018 0.0022 0.0039
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0315 0.2148 0.2141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0261 0.0252
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0977 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0059 0.0317 0.0559
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0164 0.0155
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0059 0.0317 0.6467
Loa Loa (eye worm) hypothetical protein 0.0374 0.2569 0.4535
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0059 0.0317 0.0308
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0374 0.2569 0.4535
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0073 0.0469
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0059 0.0317 0.0308
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0129
Leishmania major cathepsin L-like protease 0.0067 0.0374 0.2435
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0253 0.0447
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0977 1
Brugia malayi MH2 domain containing protein 0.0245 0.1647 0.2908
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0016 0.0028
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0097 0.1644
Brugia malayi MH1 domain containing protein 0.0017 0.0016 0.0028
Schistosoma mansoni hypothetical protein 0.0059 0.0317 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0022 0.0073
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0029 0.0051
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0065 0.0056
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0059 0.0317 0.5
Schistosoma mansoni lamin 0.0027 0.009 0.008
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.009 0.0158
Brugia malayi Smad1 0.0017 0.0016 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0374 0.2435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0129
Loa Loa (eye worm) hypothetical protein 0.0081 0.0478 0.0844
Brugia malayi Bromodomain containing protein 0.004 0.0183 0.0323
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0073 0.0469
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 0.4738
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.0184 0.0324
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0073 0.0469
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0166 0.0156
Mycobacterium ulcerans beta-lactamase 0.0151 0.0977 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0024 0.0015
Brugia malayi PHD-finger family protein 0.0026 0.0083 0.0147
Leishmania major hypothetical protein, conserved 0.0025 0.0077 0.0442
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0164 0.1488
Mycobacterium tuberculosis Conserved protein 0.0151 0.0977 0.141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0977 0.0969
Loa Loa (eye worm) hypothetical protein 0.0045 0.0216 0.0381
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0009 0.0017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0278 0.0378
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0059 0.0317 0.0308
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0136
Brugia malayi RNA binding protein 0.0129 0.082 0.1448
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0252
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Loa Loa (eye worm) beta-lactamase 0.0151 0.0977 0.1725
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0261 0.0252
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.082 0.1448
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0478 0.4479
Schistosoma mansoni eyes absent homolog 0.0089 0.0535 0.0526
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.005
Trypanosoma cruzi endonuclease G, putative 0.0224 0.1502 1
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1647 0.2908
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0136 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0073 0.0076
Loa Loa (eye worm) hypothetical protein 0.0074 0.0426 0.0752
Mycobacterium leprae conserved hypothetical protein 0.0151 0.0977 1
Schistosoma mansoni zinc finger protein 0.002 0.0043 0.0034
Brugia malayi hypothetical protein 0.0089 0.0535 0.0944
Loa Loa (eye worm) hypothetical protein 0.0089 0.0535 0.0944
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0164 0.1488
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0478 0.3082
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.0414
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Onchocerca volvulus 0.0374 0.2569 0.4513
Leishmania major cathepsin L-like protease 0.0018 0.0022 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0977 0.6482
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.005 0.0253 0.0447
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0059 0.0317 0.0523
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0097 0.0266
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0374 0.2569 0.2562
Trypanosoma brucei hypothetical protein, conserved 0.0151 0.0977 0.6482
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0016 0.0006
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0478 0.4773
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0977 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0164 0.1026
Trichomonas vaginalis esterase, putative 0.0151 0.0977 1
Mycobacterium ulcerans esterase/lipase LipP 0.0151 0.0977 1
Brugia malayi Inositol-1 0.0037 0.0164 0.029
Mycobacterium leprae Probable lipase LipE 0.0151 0.0977 1
Brugia malayi MH2 domain containing protein 0.0017 0.0016 0.0028
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0374 0.2569 0.2562
Schistosoma mansoni inositol monophosphatase 0.0037 0.0164 0.0155
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0006
Schistosoma mansoni hypothetical protein 0.0807 0.5665 0.5661
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0478 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0022 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0966 0.6802 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.009 0.008
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0059 0.0317 0.0523
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0024 0.0015
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0261 0.046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0224 0.1502 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0977 0.1725
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0252
Echinococcus granulosus beta LACTamase domain containing family member 0.0151 0.0977 0.0969
Brugia malayi beta-lactamase family protein 0.0151 0.0977 0.1725
Loa Loa (eye worm) hypothetical protein 0.0154 0.0997 0.1759
Echinococcus multilocularis lamin dm0 0.0027 0.009 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0977 0.6482
Echinococcus granulosus cathepsin l1 0.0018 0.0022 0.0012
Brugia malayi Cathepsin L-like precursor 0.0018 0.0022 0.0039
Schistosoma mansoni smad1 5 8 and 0.0017 0.0016 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0374 0.2435

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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