Detailed information for compound 729392

Basic information

Technical information
  • TDR Targets ID: 729392
  • Name: N-(naphthalen-1-ylmethyl)-1-propan-2-ylbenzim idazol-2-amine
  • MW: 315.412 | Formula: C21H21N3
  • H donors: 1 H acceptors: 1 LogP: 5.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(n1c(NCc2cccc3c2cccc3)nc2c1cccc2)C
  • InChi: 1S/C21H21N3/c1-15(2)24-20-13-6-5-12-19(20)23-21(24)22-14-17-10-7-9-16-8-3-4-11-18(16)17/h3-13,15H,14H2,1-2H3,(H,22,23)
  • InChiKey: JSUVMQUNMCUCDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-isopropyl-N-(1-naphthylmethyl)benzimidazol-2-amine
  • 1-isopropyl-N-(1-naphthylmethyl)-2-benzimidazolamine
  • (1-isopropylbenzimidazol-2-yl)-(1-naphthylmethyl)amine
  • N-(naphthalen-1-ylmethyl)-1-propan-2-yl-benzimidazol-2-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0199 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0065 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0199 0.0185
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0223 0.0276
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0033 0.0244
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0223 0.0276
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.026 0.2268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0204 0.0252
Brugia malayi jmjC domain containing protein 0.0015 0.0014 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0065 0.0051
Schistosoma mansoni ferritin light chain 0.0017 0.0038 0.0025
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0065 0.0051
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0068 0.0682
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0456 0.0442
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0065 0.0051
Loa Loa (eye worm) hypothetical protein 0.0048 0.0357 0.0356
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0068 0.0501
Echinococcus multilocularis dna polymerase kappa 0.002 0.0068 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0204 0.1844
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0033 0.0288
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0199 0.1827
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0068 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0065 0.0051
Echinococcus multilocularis dna polymerase eta 0.002 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0148 0.1423 0.1421
Echinococcus multilocularis pyruvate kinase 0.0033 0.0204 0.019
Trypanosoma brucei calpain-like protein, putative 0.0117 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0804 0.0803
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0073 0.063 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0065 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0396 0.0488
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0122
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0123 0.1109
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0173 0.016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0037 0.0248 0.0234
Loa Loa (eye worm) hypothetical protein 0.0253 0.2539 0.2538
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0065 0.0079
Schistosoma mansoni hypothetical protein 0.0031 0.0184 0.017
Echinococcus multilocularis pyruvate kinase 0.0017 0.0033 0.0019
Schistosoma mansoni ferritin light chain 0.0017 0.0038 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0184 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Echinococcus multilocularis pyruvate kinase 0.0017 0.0033 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0223 0.0276
Echinococcus multilocularis cpg binding protein 0.0061 0.0502 0.0489
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0051 0.0396 0.3519
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0777 0.8084 0.8083
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0342 0.0533
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0326 0.3075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.026 0.2426
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0501
Onchocerca volvulus Huntingtin homolog 0.0118 0.1108 0.201
Brugia malayi Temporarily assigned gene name protein 44 0.0029 0.0156 0.0192
Leishmania major hypothetical protein, conserved 0.0025 0.0123 0.1007
Brugia malayi N-terminal motif family protein 0.019 0.1864 0.2304
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0199 0.0185
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0051 0.0063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0957 1 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0073 0.063 0.5731
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0811 0.0798
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0037 0.0248 0.0234
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0068 0.0084
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0037 0.0248 0.216
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0223 0.0276
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0199 0.0185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0811 0.0798
Echinococcus multilocularis geminin 0.0691 0.7174 0.717
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.026 0.0321
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0123 0.1382
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0065 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0777 0.8084 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0125
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0014 0.0013
Trichomonas vaginalis set domain proteins, putative 0.025 0.2504 0.3098
Entamoeba histolytica Ran family GTPase 0.0045 0.0326 0.4902
Brugia malayi hypothetical protein 0.0118 0.1108 0.1369
Loa Loa (eye worm) glutaminase 2 0.0284 0.2862 0.2861
Loa Loa (eye worm) hypothetical protein 0.0148 0.1423 0.1421
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0326 0.2876
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0409 0.0505
Trichomonas vaginalis ferritin, putative 0.0017 0.0038 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0223 0.021
Onchocerca volvulus 0.0026 0.0126 0.0118
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0588 0.0575
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.0341
Schistosoma mansoni importin beta-1 0.009 0.0804 0.0791
Schistosoma mansoni cpg binding protein 0.0061 0.0502 0.0489
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0068 0.0054
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0342 0.0328
Schistosoma mansoni hypothetical protein 0.0284 0.2862 0.2852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0396 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0491 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0073 0.063 0.0779
Schistosoma mansoni thyroid hormone receptor 0.002 0.0065 0.0051
Echinococcus multilocularis pyruvate kinase 0.0017 0.0033 0.0019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0037 0.0249 0.2167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0811 0.0798
Trichomonas vaginalis glutaminase, putative 0.0284 0.2862 0.3541
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Schistosoma mansoni pyruvate kinase 0.0033 0.0204 0.019
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0055 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1028 1
Trichomonas vaginalis glucosylceramidase, putative 0.0777 0.8084 1
Schistosoma mansoni hypothetical protein 0.0691 0.7174 0.717
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0117 0.1098 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0126 0.1424
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0588 0.5298
Trypanosoma brucei calpain, putative 0.0117 0.1098 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0065 0.0051
Schistosoma mansoni DNA polymerase eta 0.002 0.0068 0.0054
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0123 0.1077
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5544 0.6859
Echinococcus granulosus importin subunit beta 1 0.009 0.0804 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Schistosoma mansoni ran 0.0045 0.0326 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Leishmania major pyruvate kinase 0.0033 0.0204 0.1751
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0073 0.063 0.5682
Giardia lamblia Pyruvate kinase 0.0033 0.0204 0.5831
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0342 0.0328
Echinococcus granulosus leukotriene A 4 hydrolase 0.0026 0.0126 0.0113
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0475 0.4548
Schistosoma mansoni ferritin 0.0017 0.0038 0.0025
Schistosoma mansoni hypothetical protein 0.0031 0.0184 0.017
Chlamydia trachomatis pyruvate kinase 0.0033 0.0204 0.5
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0065 0.0079
Echinococcus multilocularis snurportin 1 0.0957 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0065 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2184 0.2183
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0217 0.4096
Schistosoma mansoni inositol monophosphatase 0.0038 0.026 0.0246
Brugia malayi jmjC domain containing protein 0.0015 0.0014 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Trichomonas vaginalis glucosylceramidase, putative 0.0777 0.8084 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0051 0.0396 0.3593
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0021 0.0076 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0051 0.045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0055 0.0042
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0037 0.0248 0.0234
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0065 0.0051
Entamoeba histolytica hypothetical protein 0.0051 0.0396 0.6071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0125
Echinococcus multilocularis translational activator gcn1 0.0017 0.0033 0.0019
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.9953
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0098 0.0096
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0475 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.026 0.2268
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0342 0.0328
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0033 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0065 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0065 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0073 0.063 0.5731
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0051 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0777 0.8084 1
Brugia malayi mbt repeat family protein 0.0046 0.0342 0.0421
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0051 0.005
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0204 0.2403
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0204 0.0267
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0065 0.0051
Echinococcus granulosus intermediate filament protein 0.0026 0.0129 0.0116
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0129 0.0128
Schistosoma mansoni hypothetical protein 0.0824 0.8592 0.859
Loa Loa (eye worm) hypothetical protein 0.0044 0.032 0.0318
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0126 0.1037
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0501
Echinococcus granulosus expressed protein 0.0017 0.0038 0.0025
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0624 0.0772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Brugia malayi Pre-SET motif family protein 0.0033 0.0199 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0182
Schistosoma mansoni ferritin 0.0017 0.0038 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0204 0.0251
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0588 0.5298
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0129 0.0128
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0588 0.0726
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0065 0.0051
Giardia lamblia DINP protein human, muc B family 0.002 0.0068 0.1198
Echinococcus granulosus muscleblind protein 0.0148 0.1423 0.1411
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1522 0.1521
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.2539 0.3139
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0117 0.1098 1
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0624 0.0772
Brugia malayi CXXC zinc finger family protein 0.0058 0.0467 0.0576
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0204 0.1751
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0037 0.0248 0.216
Onchocerca volvulus 0.0073 0.063 0.1089
Schistosoma mansoni ran 0.0045 0.0326 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trichomonas vaginalis hypothetical protein 0.0017 0.0033 0.0041
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0117 0.1098 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Loa Loa (eye worm) hypothetical protein 0.0067 0.0567 0.0566
Echinococcus multilocularis musashi 0.0026 0.0129 0.0116
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0777 0.8084 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0223 0.1933
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.026 0.0321
Trypanosoma brucei glucosidase, putative 0.0035 0.0223 0.2024
Trypanosoma brucei hypothetical protein 0.0117 0.1098 1
Onchocerca volvulus Huntingtin homolog 0.0118 0.1108 0.201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0117 0.1098 1
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5544 0.6859
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0248 0.2309
Plasmodium vivax importin-beta 2, putative 0.009 0.0804 1
Plasmodium vivax transportin, putative 0.0017 0.0033 0.0243
Onchocerca volvulus 0.0073 0.063 0.1089
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0051 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0588 0.5351
Brugia malayi jmjC domain containing protein 0.0015 0.0014 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0804 0.7315
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0068 0.0054
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.026 0.0784
Echinococcus granulosus dna polymerase kappa 0.002 0.0068 0.0054
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0491 0.0477
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0065 0.0051
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0073 0.063 0.0617
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0037 0.0248 0.2248
Brugia malayi jmjC domain containing protein 0.006 0.0491 0.0605
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0342 0.0328
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0053 0.0064
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0342 0.0328
Brugia malayi ecdysteroid receptor 0.002 0.0065 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Loa Loa (eye worm) hypothetical protein 0.0118 0.1108 0.1107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Echinococcus granulosus aminopeptidase N 0.0073 0.063 0.0617
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0051 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0065 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.0608
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0204 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0049 0.0035
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0033 0.019
Schistosoma mansoni hypothetical protein 0.0691 0.7174 0.717
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0096
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0409 0.0396
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0021 0.0076 0.0572
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0048 0.0357 0.3164
Loa Loa (eye worm) aminopeptidase N 0.0073 0.063 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0014 0.0113
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0467 0.0466
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0123 0.1382
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0037 0.0248 0.216
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0409 0.0396
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0204 0.1844
Leishmania major importin beta-1 subunit, putative 0.0073 0.0624 0.5627
Echinococcus multilocularis GPCR, family 2 0.0031 0.0184 0.017
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0126 0.0113
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.1864 0.3466
Echinococcus granulosus pyruvate kinase 0.0033 0.0204 0.019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0044 0.032 0.2819
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0065 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0129 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0018 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0065 0.0079
Echinococcus multilocularis lamin 0.0026 0.0129 0.0116
Toxoplasma gondii exonuclease III APE 0.0019 0.0051 0.0365
Schistosoma mansoni apoferritin-2 0.0017 0.0038 0.0025
Schistosoma mansoni hypothetical protein 0.0031 0.0184 0.017
Schistosoma mansoni importin-beta 2 0.0017 0.0033 0.0019
Brugia malayi TATA binding protein associated factor 0.0026 0.0126 0.0155
Brugia malayi tumor suppressor. 0.0338 0.3431 0.4243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0101 0.0125
Brugia malayi hypothetical protein 0.0029 0.0156 0.0192
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0065 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0065 0.0064
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1522 0.151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0627 0.0614
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0037 0.0248 0.216
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0223 0.2067
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0073 0.063 0.0779
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0018 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0851 0.8874 0.8873
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0048 0.0357 0.0344
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0126 0.1424
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.0126 0.1109
Echinococcus multilocularis dnaJ subfamily B 0.0824 0.8592 0.859
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0065 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0223 0.1933
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.0608
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0223 0.0276
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0065 0.0051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0065 0.0051
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0126 0.0311
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0248 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0811 0.1002
Echinococcus multilocularis pyruvate kinase 0.0033 0.0204 0.019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.01
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1522 0.1881
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0223 0.0276
Schistosoma mansoni ferritin 0.0017 0.0038 0.0025
Schistosoma mansoni nuclear hormone receptor 0.002 0.0065 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0567 0.07
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0126 0.0113
Schistosoma mansoni alpha-glucosidase 0.0135 0.1289 0.1277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0811 0.0798
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0248 0.216
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.6919 0.6915
Schistosoma mansoni inositol monophosphatase 0.0038 0.026 0.0246
Loa Loa (eye worm) hypothetical protein 0.019 0.1864 0.1863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Mycobacterium ulcerans glutaminase 0.0284 0.2862 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0357 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Brugia malayi Inositol-1 0.0038 0.026 0.032
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0065 0.0064
Loa Loa (eye worm) tumor suppressor 0.0338 0.3431 0.343
Schistosoma mansoni hypothetical protein 0.0957 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0409 0.0408
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1522 0.151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0897 0.0896
Echinococcus granulosus hypothetical protein 0.0029 0.0156 0.0142
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0068 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0021 0.0076 0.0062
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0126 0.1037
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0126 0.1424
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0065 0.0079
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0223 0.0222
Toxoplasma gondii FATC domain-containing protein 0.0051 0.0396 0.3763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Plasmodium vivax SET domain protein, putative 0.0033 0.0199 0.2345
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0068 0.0067
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0117 0.1098 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0126 0.1037
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0204 0.1872
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0456 0.0442
Onchocerca volvulus 0.0091 0.0818 0.1452
Echinococcus granulosus pyruvate kinase 0.0017 0.0033 0.0019
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0126 0.0125
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0248 0.0305
Schistosoma mansoni lamin 0.0026 0.0129 0.0116
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0184 0.017
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0126 0.1037
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0101 0.0911
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0624 0.5627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Brugia malayi nuclear hormone receptor 0.002 0.0065 0.0079
Echinococcus multilocularis muscleblind protein 0.0148 0.1423 0.1411
Trichomonas vaginalis glucosylceramidase, putative 0.0777 0.8084 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0037 0.0248 0.3601
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0155
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0223 0.0276
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0033 0.0032
Echinococcus granulosus dnaJ subfamily B 0.0824 0.8592 0.859
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0037 0.0248 0.2248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0065 0.0051
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0065 0.0051
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0342 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0501
Echinococcus granulosus GPCR family 2 0.0031 0.0184 0.017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0065 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0588 0.5298
Brugia malayi FAT domain containing protein 0.0016 0.0025 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0021 0.0076 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Loa Loa (eye worm) hypothetical protein 0.0118 0.1108 0.1107
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0456 0.0442
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0475 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Echinococcus multilocularis transportin 1 0.0017 0.0033 0.0019
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0033 0.0189
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Echinococcus granulosus transportin 1 0.0017 0.0033 0.0019
Echinococcus multilocularis pyruvate kinase 0.0026 0.013 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0588 0.0587
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0016 0.0025 0.0012
Brugia malayi Muscleblind-like protein 0.0148 0.1423 0.1759
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0033 0.0288
Echinococcus multilocularis ferritin 0.0017 0.0038 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0068 0.0083
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0098 0.1083
Plasmodium falciparum importin beta, putative 0.009 0.0804 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0025 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0065 0.0064
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0204 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0475 0.1546
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1522 0.151
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.1818 0.1806
Leishmania major hypothetical protein, conserved 0.0017 0.0033 0.0177
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0123 0.1382
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0037 0.0248 0.216
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0065 0.0079
Schistosoma mansoni hypothetical protein 0.0073 0.0627 0.0614
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0811 0.081
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0014 0.0013
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0326 0.2956
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0126 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1167 0.1155
Entamoeba histolytica hypothetical protein 0.0073 0.0624 0.9899
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0217 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0588 0.0575
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.0126 0.1109
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.6919 0.6915
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0126 0.0113
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0475 0.4253
Loa Loa (eye worm) phosphatidylinositol 3 0.0037 0.0248 0.0247
Echinococcus granulosus pyruvate kinase 0.0017 0.0033 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0065 0.0079
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0326 0.0325
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0409 0.0396
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0342 0.0328
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0897 0.1109
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0068 0.0682
Schistosoma mansoni hypothetical protein 0.0067 0.0567 0.0554
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0068 0.0501
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0184 0.0226
Echinococcus granulosus FTZ F1 alpha 0.002 0.0065 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0123 0.1007
Onchocerca volvulus 0.0046 0.0342 0.0533
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0126 0.1424
Brugia malayi hypothetical protein 0.0026 0.0126 0.0155
Schistosoma mansoni thyroid hormone receptor 0.002 0.0065 0.0051
Schistosoma mansoni ferritin 0.0017 0.0038 0.0025
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0248 0.216
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0491 0.0477
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0475 0.0462
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0184 0.0182
Echinococcus granulosus microtubule associated protein 2 0.0667 0.6919 0.6915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Onchocerca volvulus 0.0026 0.0129 0.0124
Schistosoma mansoni pyruvate kinase 0.0033 0.0204 0.019
Echinococcus granulosus pyruvate kinase 0.0033 0.0204 0.019
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0049 0.0035
Brugia malayi jmjC domain containing protein 0.0057 0.0456 0.0562
Entamoeba histolytica protein kinase rad3, putative 0.0021 0.0076 0.0718
Echinococcus multilocularis lamin dm0 0.0026 0.0129 0.0116
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0804 0.7789
Echinococcus granulosus cpg binding protein 0.0061 0.0502 0.0489
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Leishmania major pyruvate kinase 0.0033 0.0204 0.1751
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0051 0.0298
Echinococcus multilocularis importin 5 0.0017 0.0033 0.0019
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0204 0.0267
Echinococcus multilocularis importin subunit beta 1 0.009 0.0804 0.0791
Schistosoma mansoni fkbp-rapamycin associated protein 0.0021 0.0076 0.0062
Echinococcus granulosus transcription factor Dp 1 0.004 0.0279 0.0265
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.9953
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0065 0.0051
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0456 0.0442
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0342 0.0341
Brugia malayi hypothetical protein 0.0025 0.0123 0.0151
Brugia malayi jmjC domain containing protein 0.0015 0.0014 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0627 0.0614
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0051 0.0468
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0326 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0624 0.0772
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0199 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0475 0.1546
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.9953
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0068 0.0608
Brugia malayi Pre-SET motif family protein 0.022 0.2184 0.2701
Echinococcus granulosus serine protein kinase ATM 0.0051 0.0396 0.0382
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0073 0.063 0.5682
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0065 0.0051
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0051 0.0396 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0065 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0065 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0065 0.0079
Plasmodium falciparum pyruvate kinase 0.0033 0.0204 0.2403
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0126 0.1037
Plasmodium falciparum transportin 0.0017 0.0033 0.0243
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.026 0.0246
Brugia malayi RNA, U transporter 1 0.0255 0.2556 0.3161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0051 0.0061
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0075
Leishmania major phosphatidylinositol kinase related protein, putative 0.0037 0.0249 0.2167
Trypanosoma brucei Aminopeptidase M1, putative 0.0073 0.063 0.5731
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0223 0.319
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0123 0.1007
Schistosoma mansoni coup transcription factor 0.002 0.0065 0.0051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0076 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0811 0.0798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0051 0.0561
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0475 0.0462
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0051 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Leishmania major GTP-binding protein, putative 0.0045 0.0326 0.2876
Loa Loa (eye worm) phosphatidylinositol 3 0.0037 0.0248 0.0247
Schistosoma mansoni hypothetical protein 0.0029 0.0156 0.0142
Loa Loa (eye worm) MBCTL1 0.0052 0.0409 0.0408
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0051 0.0044
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0037 0.0248 0.3601
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0065 0.0051
Brugia malayi intermediate filament protein 0.0026 0.0129 0.0159
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0013
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0588 0.0575
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Echinococcus multilocularis protein quaking 0.0029 0.0156 0.0142
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0065 0.0051
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0037 0.0248 0.0234
Brugia malayi steroid hormone receptor 0.002 0.0065 0.0079
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0204 0.0585
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.026 0.3799
Brugia malayi Peptidase family M1 containing protein 0.0073 0.063 0.0778
Schistosoma mansoni cpg binding protein 0.0061 0.0502 0.0489
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0037 0.0248 0.2248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0065 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0475 0.1546
Brugia malayi Peptidase family M1 containing protein 0.0073 0.063 0.0778
Echinococcus granulosus translational activator gcn1 0.0017 0.0033 0.0019
Echinococcus granulosus pyruvate kinase 0.0017 0.0033 0.0019
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0184 0.0226
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0037 0.0248 0.216
Schistosoma mansoni hypothetical protein 0.0029 0.0156 0.0142
Onchocerca volvulus 0.0058 0.0467 0.0775
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0804 0.7315
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0033 0.0244
Onchocerca volvulus Glucosylceramidase homolog 0.0509 0.5253 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0065 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0026 0.0126 0.0113
Leishmania major DNA polymerase kappa, putative 0.002 0.0068 0.0501
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0627 0.0614
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0588 0.9302
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0065 0.0051
Onchocerca volvulus 0.0033 0.0199 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0204 0.3786
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0033 0.0189
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0223 0.021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0051 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0204 0.0267
Schistosoma mansoni ap endonuclease 0.0019 0.0051 0.0037
Brugia malayi Importin beta-1 subunit 0.009 0.0804 0.0993
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0014 0.0013
Echinococcus granulosus protein quaking 0.0029 0.0156 0.0142
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0051 0.0037
Echinococcus granulosus lamin dm0 0.0026 0.0129 0.0116
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.1098 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Brugia malayi mbt repeat family protein 0.0046 0.0342 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0018 0.0004
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0204 0.0252
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0204 0.0203
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0026 0.0126 0.0113
Giardia lamblia GTOR 0.0037 0.0248 0.7346
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0186 0.1825 0.1814
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0326 0.2876
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0068 0.0589
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0051 0.0063
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.026 0.2356
Toxoplasma gondii aminopeptidase N protein 0.0026 0.0126 0.1109
Loa Loa (eye worm) glutaminase 0.0284 0.2862 0.2861
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0186 0.1825 0.1814
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0199 0.0185
Echinococcus multilocularis aminopeptidase N 0.0073 0.063 0.0617
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0117 0.1098 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0033 0.0019
Brugia malayi kap beta 3 protein 0.0017 0.0033 0.0039
Brugia malayi glutaminase DH11.1 0.0284 0.2862 0.354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0065 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0811 0.0798
Loa Loa (eye worm) hypothetical protein 0.0048 0.0357 0.0356
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0073 0.063 0.0617
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0279 0.0265
Schistosoma mansoni hypothetical protein 0.0031 0.0184 0.017
Trichomonas vaginalis ran, putative 0.0045 0.0326 0.0403
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0126 0.1139
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0223 0.1933
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0126 0.0156
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0065 0.0051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0204 0.0251
Echinococcus granulosus lamin 0.0026 0.0129 0.0116
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0248 0.2248
Schistosoma mansoni cpg binding protein 0.0058 0.0467 0.0454
Brugia malayi hypothetical protein 0.0073 0.0627 0.0775
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0326 0.0312
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0026 0.0126 0.0125
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0475 0.0462
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0126 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0248 0.0307
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0203
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0068 0.0084
Echinococcus granulosus ferritin 0.0017 0.0038 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0509 0.5253 0.6499
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0018 0.0004
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0326 0.0312
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.026 1
Entamoeba histolytica aminopeptidase, putative 0.0073 0.063 1
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0126 0.1037
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0068 0.0054
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0126 0.1037
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1423 0.1411
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0117 0.1098 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0051 0.0341
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0024
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0023 0.0101 0.0863
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0073 0.063 0.5682
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0326 0.3947
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.026 0.0246
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0016 0.0025 0.0012
Echinococcus multilocularis serine protein kinase ATM 0.0051 0.0396 0.0382
Schistosoma mansoni alpha-glucosidase 0.0135 0.1289 0.1277
Schistosoma mansoni ap endonuclease 0.0019 0.0051 0.0037
Schistosoma mansoni alpha glucosidase 0.0035 0.0223 0.021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0055 0.0042
Loa Loa (eye worm) inositol-1 0.0038 0.026 0.0259
Schistosoma mansoni intermediate filament proteins 0.0026 0.0129 0.0116
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Echinococcus granulosus dna polymerase eta 0.002 0.0068 0.0054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.026 0.0321
Trypanosoma cruzi Aminopeptidase M1, putative 0.0073 0.063 0.5682
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.1818 0.1806
Onchocerca volvulus 0.025 0.2504 0.4702
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0037 0.0248 0.0234
Loa Loa (eye worm) hypothetical protein 0.0026 0.0124 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.0608
Trypanosoma cruzi aminopeptidase, putative 0.0073 0.063 0.5682
Onchocerca volvulus 0.0026 0.0129 0.0124
Echinococcus granulosus importin 5 0.0017 0.0033 0.0019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0199 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0065 0.0079
Mycobacterium ulcerans aminopeptidase N PepN 0.0073 0.063 0.2095
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.026 0.2268
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0051 0.0605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0125
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0777 0.8084 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0065 0.0051
Brugia malayi hypothetical protein 0.0073 0.063 0.0778
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0037 0.0248 0.2248
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0223 0.0276
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0204 0.9244
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0068 0.0105
Loa Loa (eye worm) peptidase family M1 containing protein 0.0026 0.0126 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0076 0.0094
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0068 0.0083
Echinococcus multilocularis expressed protein 0.0017 0.0038 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0199 0.0185
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0223 0.0276
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0048 0.0357 0.0344
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0037 0.0248 0.0234
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0051 0.0341
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0204 0.1751
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0037 0.0248 0.216
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.9953
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0491 0.0489
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0326 0.0401
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0223 0.319
Brugia malayi hypothetical protein 0.0016 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0608
Leishmania major phosphatidylinositol 3-kinase, putative 0.0037 0.0248 0.216
Schistosoma mansoni glutaminase 0.0284 0.2862 0.2852
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0223 0.0275
Echinococcus granulosus geminin 0.0691 0.7174 0.717
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0065 0.0051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0326 0.3947
Schistosoma mansoni apoferritin-2 0.0017 0.0038 0.0025
Schistosoma mansoni lamin 0.0026 0.0129 0.0116
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0409 0.0396
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0073 0.063 0.0617
Brugia malayi nuclear receptor NHR-88 0.002 0.0065 0.0079
Leishmania major DNA polymerase eta, putative 0.002 0.0068 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0065 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0811 0.0798
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0409 0.0396
Trypanosoma brucei unspecified product 0.002 0.0068 0.0608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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