Detailed information for compound 732085

Basic information

Technical information
  • TDR Targets ID: 732085
  • Name: ethyl 1-[[4-(2-hydroxyethoxy)phenyl]methyl]-3 -(phenylmethyl)piperidine-3-carboxylate
  • MW: 397.507 | Formula: C24H31NO4
  • H donors: 1 H acceptors: 2 LogP: 3.54 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCOc1ccc(cc1)CN1CCCC(C1)(Cc1ccccc1)C(=O)OCC
  • InChi: 1S/C24H31NO4/c1-2-28-23(27)24(17-20-7-4-3-5-8-20)13-6-14-25(19-24)18-21-9-11-22(12-10-21)29-16-15-26/h3-5,7-12,26H,2,6,13-19H2,1H3
  • InChiKey: HEZODWZMXZPZDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[4-(2-hydroxyethoxy)phenyl]methyl]-3-(phenylmethyl)-3-piperidinecarboxylic acid ethyl ester
  • 3-(benzyl)-1-[4-(2-hydroxyethoxy)benzyl]nipecotic acid ethyl ester
  • ethyl 3-benzyl-1-[4-(2-hydroxyethoxy)benzyl]piperidine-3-carboxylate
  • MLS000735120
  • SMR000319431

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0245 0.2713 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0252 0.28 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0647 0.2312
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0054 0.0054
Brugia malayi Cam kinase protein 1 0.0064 0.0647 0.2312
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0035 0.0043
Toxoplasma gondii sugar transporter ST2 0.0029 0.0254 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Schistosoma mansoni glucose transporter 0.0029 0.0254 0.0316
Loa Loa (eye worm) hypothetical protein 0.0046 0.045 0.1608
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0187 0.4152
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0192
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0709
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.028 0.0306
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0715
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0647 0.8623
Brugia malayi nuclear hormone receptor 0.001 0.0035 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0715
Trypanosoma cruzi hexose transporter 0.0065 0.0657 0.8747
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0648 0.0977
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0362 0.1334
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.045 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.01 0.0109
Schistosoma mansoni hypothetical protein 0.0025 0.0204 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0125
Schistosoma mansoni sugar transporter 0.0029 0.0254 0.0316
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0187 0.4152
Schistosoma mansoni sugar transporter 0.0029 0.0254 0.0316
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0055 0.0198
Onchocerca volvulus 0.0035 0.0316 0.1049
Schistosoma mansoni zinc finger protein 0.0026 0.0212 0.0264
Plasmodium falciparum mitogen-activated protein kinase 2 0.0336 0.3758 0.3758
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0035 0.0043
Trypanosoma brucei sugar transporter, putative 0.0029 0.0254 0.3384
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0134 0.0134
Brugia malayi Bromodomain containing protein 0.0046 0.0448 0.1599
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.01 0.0227
Mycobacterium ulcerans lipase LipD 0.0039 0.0362 0.8036
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Trypanosoma cruzi ISWI complex protein 0.0018 0.0131 0.1743
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0038 0.0508
Schistosoma mansoni hypothetical protein 0.0208 0.2295 0.2858
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0253 0.0315
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0254 0.0907
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0119 0.0301
Onchocerca volvulus 0.0029 0.0254 0.0818
Onchocerca volvulus 0.0029 0.0254 0.0818
Schistosoma mansoni glucose transport protein 0.0208 0.2295 0.2858
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0751 0.0751
Echinococcus granulosus dnaJ subfamily B 0.0407 0.4568 0.5688
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2742 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0362 0.1334
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0187 0.249
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Trypanosoma brucei ISWI complex protein 0.0018 0.0131 0.1743
Echinococcus granulosus tumor protein p63 0.0333 0.3723 0.4636
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0751 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0054 0.0262
Loa Loa (eye worm) hypothetical protein 0.0052 0.0515 0.1838
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0035 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0668
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0254 0.0278
Entamoeba histolytica protein kinase, putative 0.0064 0.0647 0.8498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0125
Loa Loa (eye worm) hypothetical protein 0.0039 0.0362 0.1292
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0633 1
Echinococcus multilocularis tumor protein p63 0.0333 0.3723 0.4076
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0254 0.0316
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0657 0.8747
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0054 0.0067
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0054 0.3127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0762 0.0949
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0254 0.0798
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0204 0.073
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.1098
Echinococcus granulosus solute carrier family 22 0.0029 0.0254 0.0316
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0647 0.0806
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0633 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.01 0.015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0187 0.4152
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0657 0.2421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0125
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0254 0.0907
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0035 0.0125
Schistosoma mansoni coup transcription factor 0.001 0.0035 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0172 0.3815
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0254 0.0383
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0648 0.0977
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0806
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0172 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0633 0.8305
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0806
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0187 0.4152
Echinococcus granulosus General substrate transporter 0.0179 0.1961 0.2442
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Brugia malayi hypothetical protein 0.0029 0.0254 0.0907
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0125
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.0124
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0155 0.0193
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0054 0.0067
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0099 0.0355
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0187 0.0668
Loa Loa (eye worm) sugar transporter 0.0029 0.0254 0.0907
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0039 0.0362 0.1292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0515 0.0641
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0602 0.0659
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0668
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.045 0.7117
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0134 0.0134
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0657 0.8747
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0362 0.1292
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0038 0.0508
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0054 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0035 0.0043
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0647 0.2312
Mycobacterium tuberculosis Conserved protein 0.0039 0.0362 0.1197
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0054 0.0054
Plasmodium vivax sugar transporter, putative 0.0029 0.0254 0.0254
Schistosoma mansoni ap endonuclease 0.0019 0.0134 0.0167
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.0038 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0254 0.0936
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0362 0.4819
Entamoeba histolytica hypothetical protein 0.0074 0.0762 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Brugia malayi ecdysteroid receptor 0.001 0.0035 0.0125
Echinococcus multilocularis solute carrier family 22 0.0029 0.0254 0.0278
Giardia lamblia Hexose transporter 0.0029 0.0254 0.4016
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0038 0.0508
Brugia malayi isocitrate dehydrogenase 0.0016 0.01 0.0356
Trichomonas vaginalis esterase, putative 0.0039 0.0362 0.1334
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0254 0.0936
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.001 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.0054 0.1193
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0362 0.1197
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.0427
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0187 0.4152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0307 0.1098
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0647 0.0806
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.028 0.0348
Onchocerca volvulus 0.0039 0.0362 0.1221
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0515 0.0563
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0633 0.0788
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.0427
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0038 0.0508
Echinococcus multilocularis General substrate transporter 0.0179 0.1961 0.2147
Onchocerca volvulus 0.0029 0.0254 0.0818
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0648 0.0648
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0762 0.0949
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.045 0.045
Echinococcus multilocularis microtubule associated protein 2 0.0711 0.803 0.8792
Loa Loa (eye worm) hypothetical protein 0.0085 0.0894 0.3194
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.037 0.1228
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0054 0.0849
Onchocerca volvulus 0.0032 0.028 0.0914
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0125
Loa Loa (eye worm) hypothetical protein 0.0062 0.0633 0.2259
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.045 0.0561
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0124
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0254 0.0254
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0657 0.8747
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.01 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0254 0.0936
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0134 0.0354
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0657 0.2421
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Brugia malayi hypothetical protein 0.0029 0.0254 0.0907
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0054 0.0705
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0006
Brugia malayi hypothetical protein 0.0074 0.0762 0.272
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0038 0.0508
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.2295 0.2513
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0648 0.0648
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0187 0.2454
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0124
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0038
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0254 0.3384
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0035 0.0043
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2858
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Onchocerca volvulus 0.0049 0.0477 0.165
Brugia malayi hypothetical protein 0.0029 0.0254 0.0907
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0155 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0487 0.1738
Leishmania major hypothetical protein, conserved 0.001 0.0038 0.0508
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0362 0.0451
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0254 0.3384
Echinococcus granulosus solute carrier family 22 0.0029 0.0254 0.0316
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0054 0.0192
Leishmania major hypothetical protein, conserved 0.0029 0.0254 0.3384
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0187 0.0668
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0054 0.0849
Schistosoma mansoni protein kinase 0.0064 0.0647 0.0806
Echinococcus multilocularis cpg binding protein 0.0039 0.0365 0.0399
Toxoplasma gondii sugar transporter ST1 0.0029 0.0254 0.0383
Echinococcus multilocularis solute carrier family 22 0.0029 0.0254 0.0278
Echinococcus granulosus FTZ F1 alpha 0.001 0.0035 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0487 0.1738
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.4568 0.5001
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0657 0.8747
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0254 0.5643
Echinococcus granulosus microtubule associated protein 2 0.0711 0.803 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.045 0.0493
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0035 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0109 0.026
Leishmania major histidyl-tRNA synthetase, putative 0.0007 0 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0134 0.2972
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0035 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.008 0.0286
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0633 0.0693
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0119 0.2654
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0031 0.0039
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0254 0.0798
Schistosoma mansoni hypothetical protein 0.0018 0.0131 0.0163
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0657 0.2421
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0043
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0054 0.0059
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0031 0.0034
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.045 0.5997
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0254 0.0278
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0031 0.0039
Trypanosoma brucei glucose transporter 1E 0.0065 0.0657 0.8747
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.001 0.0036
Leishmania major glucose transporter, lmgt2 0.0065 0.0657 0.8747
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0362 0.1197
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0187 0.2454
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0155 0.0193
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0035 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0187 0.249
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0254 0.3384
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0362 0.1334
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.045 1
Entamoeba histolytica hypothetical protein 0.0046 0.045 0.591
Brugia malayi nuclear receptor NHR-88 0.001 0.0035 0.0125
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0633 0.0788
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0134 0.5267
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0213 0.0759
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0362 0.5444
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Mycobacterium tuberculosis Conserved protein 0.0039 0.0362 0.1197
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0125
Brugia malayi major facilitator superfamily protein 0.0029 0.0254 0.0907
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0602 0.075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0415 0.0454
Schistosoma mansoni hypothetical protein 0.0169 0.1845 0.2298
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.045 0.0561
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0035 0.0125
Loa Loa (eye worm) hypothetical protein 0.0039 0.0362 0.1292
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.0427
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.045 0.166
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0751 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0125
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0007 0 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0362 0.1334
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2513
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0043
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.045 0.6932
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.0109
Plasmodium vivax CDK-related protein kinase 6, putative 0.0884 1 1
Echinococcus granulosus zinc finger protein 0.0026 0.0212 0.0264
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0362 0.8036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0668
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0336 0.3758 0.5668
Onchocerca volvulus 0.0029 0.0254 0.0818
Leishmania major protein kinase, putative 0.0064 0.0647 0.8623
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0134 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0125
Mycobacterium ulcerans beta-lactamase 0.0039 0.0362 0.8036
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0362 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0125
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0134 0.0493
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0258 0.0321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Loa Loa (eye worm) hypothetical protein 0.0062 0.0633 0.2259
Schistosoma mansoni ap endonuclease 0.0019 0.0134 0.0167
Trypanosoma cruzi histidyl-tRNA synthetase 0.0007 0 0.0005
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0119 0.0119
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0134 0.2115
Onchocerca volvulus 0.0029 0.0254 0.0818
Loa Loa (eye worm) hypothetical protein 0.005 0.0487 0.1738
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0362 0.1197
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0253 0.0315
Loa Loa (eye worm) beta-lactamase 0.0039 0.0362 0.1292
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0054 0.1193
Toxoplasma gondii ABC1 family protein 0.0039 0.0362 0.0546
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0125
Brugia malayi hypothetical protein 0.0252 0.28 1
Onchocerca volvulus 0.0029 0.0254 0.0818
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.045 0.5997
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0657 0.2421
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0007 0 0.0001
Onchocerca volvulus 0.0029 0.0254 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0125
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0254 0.5643
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0035 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Onchocerca volvulus 0.0051 0.0508 0.1765
Brugia malayi Bromodomain containing protein 0.0093 0.0976 0.3485
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0647 0.2312
Onchocerca volvulus 0.0029 0.0254 0.0818
Echinococcus granulosus cpg binding protein 0.0039 0.0365 0.0454
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0187 0.249
Giardia lamblia Sugar-proton symporter 0.0029 0.0254 0.4016
Leishmania major glycyl tRNA synthetase, putative 0.0007 0 0.0005
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.045 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0316 0.1128
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0007 0 0.0001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.01 0.1327
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.001 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.001 0.0036
Toxoplasma gondii protein kinase, putative 0.0588 0.663 1
Echinococcus multilocularis geminin 0.0169 0.1845 0.202
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.01 0.01
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0254 0.0316
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0657 0.8747
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Leishmania major glucose transporter, lmgt3 0.0065 0.0657 0.8747
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0765 0.0838
Schistosoma mansoni glucose transport protein 0.0208 0.2295 0.2858
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0134 0.1782
Entamoeba histolytica protein kinase, putative 0.0064 0.0647 0.8498
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0031 0.0039
Toxoplasma gondii exonuclease III APE 0.0019 0.0134 0.0202
Onchocerca volvulus 0.0029 0.0254 0.0818
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.2295 0.3462
Loa Loa (eye worm) hypothetical protein 0.0039 0.0362 0.1292
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0254 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0134 0.1782
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0633 0.0788
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0751 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0254 0.0936
Brugia malayi Pre-SET motif family protein 0.0215 0.2375 0.8481
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0035 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0657 0.2421
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0007 0 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0035 0.0125
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0119 0.2654
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0648 0.0648
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0751 0.1132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0705
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0109
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0007 0 0.0008
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0633 0.2332
Brugia malayi Pre-SET motif family protein 0.0032 0.028 0.0999
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0254 0.0907
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.028 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0362 0.4819
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2858
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Onchocerca volvulus 0.0039 0.0362 0.1221
Entamoeba histolytica hypothetical protein 0.0074 0.0762 1
Schistosoma mansoni zinc finger protein 0.0018 0.0131 0.0163
Echinococcus granulosus geminin 0.0169 0.1845 0.2298
Schistosoma mansoni hypothetical protein 0.0407 0.4568 0.5688
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.9134 1
Schistosoma mansoni hypothetical protein 0.0169 0.1845 0.2298
Leishmania major glucose transporter, lmgt1 0.0065 0.0657 0.8747
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0187 0.4152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0038
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0134 0.0167
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0362 0.1197
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0657 0.2421
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0124
Schistosoma mansoni survival motor neuron protein 0.0051 0.0508 0.0632
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0362 0.1334
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0187 0.2454
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0109 0.026
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0141
Schistosoma mansoni protein kinase 0.0064 0.0647 0.0806
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.01 0.1327
Brugia malayi beta-lactamase family protein 0.0039 0.0362 0.1292
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0362 0.4819
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0751 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0172 0.3815
Loa Loa (eye worm) hypothetical protein 0.0051 0.0499 0.1782
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0035 0.0043
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0187 0.4152
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0099 0.0355
Loa Loa (eye worm) hypothetical protein 0.0046 0.0449 0.1602
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0054 0.0192
Echinococcus multilocularis solute carrier family 22 0.0029 0.0254 0.0278
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0134 0.7789
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0648 0.0977
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.001 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0125
Schistosoma mansoni sugar transporter 0.0029 0.0254 0.0316
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0054 0.0715
Onchocerca volvulus 0.0029 0.0254 0.0818
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0038 0.0141
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0187 0.055
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Onchocerca volvulus 0.0029 0.0254 0.0818
Brugia malayi beta-lactamase 0.0039 0.0362 0.1292
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0323 0.4299
Onchocerca volvulus 0.0029 0.0254 0.0818
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0515 0.0641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.028 0.0348
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0751 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.045 0.0561
Schistosoma mansoni hypothetical protein 0.0034 0.0307 0.0383
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0362 0.0451
Echinococcus granulosus GPCR family 2 0.0016 0.0099 0.0124
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0054 0.0192
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0362 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0064 0.0647 0.2312
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0099 0.0355
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.01 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0362 0.0451
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.28 0.3487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0109 0.026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0487 0.1738
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Echinococcus multilocularis zinc finger protein 0.0026 0.0212 0.0232
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2513
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0415 0.0517
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Brugia malayi CXXC zinc finger family protein 0.0035 0.0316 0.1128
Brugia malayi beta-lactamase family protein 0.0039 0.0362 0.1292
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0709
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0751 0.0751
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.01 0.015
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0709
Onchocerca volvulus 0.0029 0.0254 0.0818
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0134 0.1782
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0648 0.0648
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) sugar transporter 0.0208 0.2295 0.8197
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0035 0.0125
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0362 0.8036
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0134 0.0146
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.045 0.5997
Schistosoma mansoni hypothetical protein 0.0074 0.0762 0.0949
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.01 0.1327
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Schistosoma mansoni bromodomain containing protein 0.0007 0.0002 0.0002
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.045 0.0679
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0035 0.0043
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0054 0.0192
Brugia malayi PHD-finger family protein 0.0032 0.0286 0.1021
Entamoeba histolytica hypothetical protein 0.0074 0.0762 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0131 0.1743
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0657 0.8747
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0362 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Loa Loa (eye worm) hypothetical protein 0.0049 0.0481 0.1719
Loa Loa (eye worm) hypothetical protein 0.0049 0.0477 0.1703
Plasmodium vivax SET domain protein, putative 0.0032 0.028 0.028
Schistosoma mansoni sugar transporter 0.0029 0.0254 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2375 0.8481
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0772 0.0962
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0254 0.0936
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2513
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0031 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0035 0.0125
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0254 0.0936
Mycobacterium ulcerans hypothetical protein 0.001 0.0038 0.0848
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.0427
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.01 0.1327
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0125
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0362 0.0396
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.28 0.3065
Loa Loa (eye worm) hypothetical protein 0.0053 0.053 0.1893
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0109
Brugia malayi Sugar transporter family protein 0.0208 0.2295 0.8197
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0648 0.0648
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0253 0.0277
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.0054 0.2114
Schistosoma mansoni protein kinase 0.0064 0.0647 0.0806
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0254 0.3384
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Schistosoma mansoni nuclear hormone receptor 0.001 0.0035 0.0043
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0254 0.0907
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0055 0.0069
Mycobacterium tuberculosis Conserved protein 0.0039 0.0362 0.1197
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.0054 0.2114
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2713 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0633 0.2259
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.037 0.5587
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0254 0.3384
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0508 0.1813
Leishmania major hypothetical protein, conserved 0.0018 0.0131 0.1743
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0648 0.0648
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0187 0.055
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0043
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0035 0.0043
Leishmania major hypothetical protein, conserved 0.001 0.0038 0.0508
Plasmodium falciparum hexose transporter 0.0208 0.2295 0.2295
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.01 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0515 0.0641
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0054 0.0081
Brugia malayi lysyl-tRNA synthetase 0.0046 0.045 0.1608
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2295 0.846
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0715 0.1079
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Schistosoma mansoni microtubule-associated protein tau 0.0711 0.803 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0134 0.1756
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0035 0.0038
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0054 0.0059
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2858
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0385 0.1419
Schistosoma mansoni cpg binding protein 0.0035 0.0316 0.0393
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0155 0.017
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.045 0.045
Brugia malayi Isocitrate dehydrogenase 0.0016 0.01 0.0356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.001 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0035 0.0043
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0054 0.0192
Echinococcus multilocularis GPCR, family 2 0.0016 0.0099 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0125
Trichomonas vaginalis helicase, putative 0.0008 0.001 0.0036
Onchocerca volvulus 0.0029 0.0254 0.0818
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Chlamydia trachomatis histidine--tRNA ligase 0.0007 0 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0187 0.2503
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0038
Trypanosoma brucei glucose transporter 2A 0.0065 0.0657 0.8747
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0647 0.2386
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0125
Loa Loa (eye worm) hypothetical protein 0.0016 0.0099 0.0355
Brugia malayi steroid hormone receptor 0.001 0.0035 0.0125
Treponema pallidum glycyl-tRNA synthetase 0.0007 0 0.002
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0633 0.2259
Plasmodium vivax hexose transporter 0.0208 0.2295 0.2295
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Schistosoma mansoni cpg binding protein 0.0039 0.0365 0.0454
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0043
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2295 0.2858
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Mycobacterium ulcerans hypothetical protein 0.0039 0.0362 0.8036
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0657 0.2421
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0134 0.0478
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0134 0.0478
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Brugia malayi Sugar transporter family protein 0.0029 0.0254 0.0907
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0035 0.0043
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0648 0.0648
Schistosoma mansoni cpg binding protein 0.0039 0.0365 0.0454
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0907
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0007 0 0.0005
Onchocerca volvulus 0.0029 0.0254 0.0818
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0054 0.0067
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0765 0.0953
Schistosoma mansoni bromodomain containing protein 0.0078 0.0814 0.1014
Mycobacterium ulcerans sugar transporter 0.0029 0.0254 0.5643
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.001 0.0036
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0362 0.1197
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0054 0.0058
Mycobacterium ulcerans hypothetical protein 0.0023 0.0187 0.4152
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0715
Onchocerca volvulus 0.0023 0.0187 0.0568
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0163 0.0584
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0806
Trypanosoma brucei histidyl-tRNA synthetase 0.0007 0 0.0005
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0647 0.0709
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0254 0.5643
Echinococcus granulosus solute carrier family 22 0.0029 0.0254 0.0316
Brugia malayi Sugar transporter family protein 0.0029 0.0254 0.0907
Entamoeba histolytica hypothetical protein 0.0074 0.0762 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0109 0.026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.001 0.0036
Schistosoma mansoni glucose transport protein 0.0208 0.2295 0.2858
Onchocerca volvulus 0.0039 0.0362 0.1221
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.037 0.1228
Mycobacterium leprae Probable lipase LipE 0.0039 0.0362 0.5444
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0 0.0005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.01 0.0356
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0043
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0648 0.0648
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.01 0.1327
Toxoplasma gondii sugar transporter ST3 0.0029 0.0254 0.0383
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.001 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0035 0.0043
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0007 0 0.0014
Leishmania major hypothetical protein, conserved 0.0039 0.0362 0.4819
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0336 0.3758 0.3758
Brugia malayi major facilitator superfamily protein 0.0029 0.0254 0.0907
Toxoplasma gondii anticodon binding domain-containing protein 0.0007 0 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0055 0.0061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0362 0.1292
Plasmodium falciparum protein kinase 7 0.0588 0.663 0.663
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0134 0.1782
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0254 0.0907
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0362 0.1197
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0125
Schistosoma mansoni hypothetical protein 0.0051 0.0508 0.0632
Echinococcus granulosus solute carrier family 22 0.0029 0.0254 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0254 0.0936
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0187 0.0668
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0054 0.1193
Onchocerca volvulus Putative transporter 0.0029 0.0254 0.0818
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0762 0.0834
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0043
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0254 0.0316
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0187 0.2503
Loa Loa (eye worm) hypothetical protein 0.0039 0.0362 0.1292
Trypanosoma brucei glucose transporter, putative 0.0065 0.0657 0.8747
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0657 0.8747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0125
Onchocerca volvulus 0.0029 0.0254 0.0818
Echinococcus multilocularis solute carrier family 22 0.0029 0.0254 0.0278
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0477 0.0594

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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