Detailed information for compound 757453

Basic information

Technical information
  • TDR Targets ID: 757453
  • Name: 5-methyl-1-[2-(4-methylphenoxy)ethyl]indole-2 ,3-dione
  • MW: 295.332 | Formula: C18H17NO3
  • H donors: 0 H acceptors: 2 LogP: 3.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)OCCN1c2ccc(cc2C(=O)C1=O)C
  • InChi: 1S/C18H17NO3/c1-12-3-6-14(7-4-12)22-10-9-19-16-8-5-13(2)11-15(16)17(20)18(19)21/h3-8,11H,9-10H2,1-2H3
  • InChiKey: YLRIIEKOEYGRFS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-methyl-1-[2-(4-methylphenoxy)ethyl]indoline-2,3-dione
  • 5-methyl-1-[2-(4-methylphenoxy)ethyl]isatin
  • MLS000707902
  • SMR000288969
  • ZINC02706820
  • 5-Methyl-1-(2-p-tolyloxy-ethyl)-1H-indole-2,3-dione
  • BAS 07249950

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Ras converting CAAX endopeptidase 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Saccharomyces cerevisiae Rce1p Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi CAAX amino terminal protease family protein Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans ras and a-factor terminal proteolysis Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni family U48 unassigned peptidase (U48 family) Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica CAAX prenyl protease family Get druggable targets OG5_129169 All targets in OG5_129169
Leishmania infantum CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani CAAX prenyl protease 2, putative Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis CAAX prenyl protease 2 Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Schistosoma mansoni family U48 unassigned peptidase (U48 family) Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi CAAX prenyl protease 2, putative Get druggable targets OG5_129169 All targets in OG5_129169
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_129169 All targets in OG5_129169
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48), putative Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus CAAX prenyl protease 2 Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia Hypothetical protein Get druggable targets OG5_129169 All targets in OG5_129169
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K08658 prenyl protein peptidase, putative Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans ras and a-factor terminal proteolysis Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense CAAX amino terminal protease, putative Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei CAAX amino terminal protease, putative Get druggable targets OG5_129169 All targets in OG5_129169
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Brugia malayi hypothetical protein Ras converting CAAX endopeptidase 1 225 aa 181 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0043 0.0379 0.0565
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0232 0.0681
Mycobacterium ulcerans hypothetical protein 0.0029 0.0198 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0336 0.0322
Plasmodium vivax heterochromatin protein 1, putative 0.0014 0.0017 0.005
Plasmodium falciparum phd finger protein, putative 0.0031 0.0232 0.0681
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0874 0.339
Loa Loa (eye worm) hypothetical protein 0.0054 0.0505 0.1479
Brugia malayi beta-lactamase family protein 0.0043 0.0379 0.1099
Echinococcus multilocularis chromobox protein 2 0.0014 0.0017 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0108 0.0093
Onchocerca volvulus 0.0058 0.0559 0.507
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0287
Toxoplasma gondii CAAX amino terminal protease family protein 0.0046 0.0406 0.5356
Brugia malayi jmjC domain containing protein 0.0103 0.1101 0.3279
Echinococcus multilocularis peregrin 0.0031 0.0232 0.0217
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.1088 0.3239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0198 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0108 0.0319
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0113 0.0379
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0198 0.0274
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0379 0.1395
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5866 0.586
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0017 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0041 0.0026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0108 0.0093
Onchocerca volvulus 0.0043 0.0379 0.3394
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0287
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0079 0.0065
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.007 0.0698 0.2061
Schistosoma mansoni DNA polymerase eta 0.0021 0.0108 0.0093
Onchocerca volvulus Alhambra homolog 0.0031 0.0232 0.202
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0155 0.1735 0.1722
Echinococcus multilocularis Chromo domain 0.0014 0.0017 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0017 0.005
Plasmodium vivax protease, putative 0.0046 0.0406 0.1194
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0017 0.0002
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0381 0.0367
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.082 0.2923
Brugia malayi Protein cec-1. 0.0014 0.0017 0.0007
Echinococcus granulosus dna polymerase kappa 0.0021 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Echinococcus granulosus cpg binding protein 0.0037 0.0296 0.0281
Echinococcus granulosus chromobox protein 1 0.0084 0.0874 0.0861
Treponema pallidum hypothetical protein 0.0291 0.3398 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0742 0.1929
Onchocerca volvulus 0.0014 0.0017 0.0021
Brugia malayi CAAX amino terminal protease family protein 0.0221 0.2545 0.7638
Schistosoma mansoni lamin 0.0033 0.0246 0.0232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0198 0.0553
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0105 0.1123 0.3345
Schistosoma mansoni kinase 0.0052 0.0479 0.0465
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0062 0.0142
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0017 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0108 0.0281
Giardia lamblia Hypothetical protein 0.0221 0.2545 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0108 0.0037
Schistosoma mansoni chromobox protein 0.0014 0.0017 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1099
Brugia malayi Bromodomain containing protein 0.0031 0.0232 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0015 0.0026 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0246 0.0698
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Mycobacterium tuberculosis Conserved protein 0.0043 0.0379 0.0858
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.011 0.0323
Entamoeba histolytica CAAX amino terminal protease family 0.0046 0.0406 0.1537
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3328 0.3318
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0078
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.082 0.0807
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0467 0.1782
Schistosoma mansoni intermediate filament proteins 0.0033 0.0246 0.0232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0418 0.1217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0198 0.031
Onchocerca volvulus 0.0043 0.0379 0.3394
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1099
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0287
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0379 0.0858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0418 0.0404
Loa Loa (eye worm) helicase 0.0014 0.0017 0.0007
Toxoplasma gondii ABC1 family protein 0.0043 0.0379 0.4988
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0379 0.0858
Brugia malayi beta-lactamase 0.0043 0.0379 0.1099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0198 0.0553
Schistosoma mansoni survival motor neuron protein 0.0058 0.0559 0.0545
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0113 0.0379
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0745 0.0732
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.0654
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0379 0.1099
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0379 0.1431
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0198 0.0274
Brugia malayi CHD4 protein 0.0016 0.0041 0.008
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0155 0.1735 0.1722
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0379 0.1431
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0742 0.1929
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0198 0.0274
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.011 0.0323
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0379 0.0858
Giardia lamblia Kinase, PLK 0.0102 0.1088 0.402
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0379 0.1115
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0742 0.0729
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0418 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0108 0.0319
Brugia malayi PHD-finger family protein 0.0031 0.0232 0.0654
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5866 0.586
Mycobacterium tuberculosis Probable integral membrane protein 0.0046 0.0406 0.0939
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0108 0.0281
Schistosoma mansoni hypothetical protein 0.0494 0.5866 0.586
Loa Loa (eye worm) voltage-gated potassium channel 0.0152 0.1703 0.5095
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.1101 0.1088
Loa Loa (eye worm) hypothetical protein 0.0221 0.2545 0.7638
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0742 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0198 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Brugia malayi beta-lactamase family protein 0.0043 0.0379 0.1099
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0462 0.1762
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.065 0.872
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0017 0.0007
Echinococcus multilocularis CAAX prenyl protease 2 0.0221 0.2545 0.2534
Echinococcus multilocularis dna polymerase eta 0.0021 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0286 0.3328 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0418 0.0404
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0041 0.0026
Brugia malayi CXXC zinc finger family protein 0.0035 0.0272 0.0776
Echinococcus multilocularis musashi 0.0033 0.0246 0.0232
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0198 0.0716
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0411 0.0397
Mycobacterium tuberculosis Conserved protein 0.0043 0.0379 0.0858
Entamoeba histolytica CAAX prenyl protease family 0.0221 0.2545 1
Schistosoma mansoni cpg binding protein 0.0037 0.0296 0.0281
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0108 0.036
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0742 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0232 0.2957
Echinococcus granulosus geminin 0.0205 0.2342 0.2331
Echinococcus multilocularis chromobox protein 1 0.0084 0.0874 0.0861
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0108 0.0037
Mycobacterium ulcerans beta-lactamase 0.0043 0.0379 0.0824
Loa Loa (eye worm) hypothetical protein 0.0033 0.0252 0.0717
Trypanosoma brucei polo-like protein kinase 0.0102 0.1088 0.4211
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0041 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0418 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Echinococcus granulosus lamin dm0 0.0033 0.0246 0.0232
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0379 0.0365
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0221 0.2545 0.2534
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0232 0.0654
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0041 0.008
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0017 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0379 0.0858
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0017 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0379 0.1099
Leishmania major hypothetical protein, conserved 0.0043 0.0379 0.1112
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0336 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0424 0.1609
Mycobacterium ulcerans lipase LipD 0.0043 0.0379 0.0824
Schistosoma mansoni hypothetical protein 0.0071 0.072 0.0706
Onchocerca volvulus 0.0014 0.0017 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0062 0.0142
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0002
Echinococcus granulosus Chromo domain 0.0014 0.0017 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0108 0.0319
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0336 0.097
Echinococcus granulosus CAAX prenyl protease 2 0.0221 0.2545 0.2534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0418 0.0404
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0108 0.0319
Schistosoma mansoni hypothetical protein 0.0205 0.2342 0.2331
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Echinococcus granulosus lamin 0.0033 0.0246 0.0232
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0041 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0198 0.031
Echinococcus granulosus GPCR family 2 0.0033 0.0252 0.0238
Mycobacterium ulcerans integral membrane protein 0.0046 0.0406 0.0905
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0221 0.2545 1
Onchocerca volvulus 0.0035 0.0272 0.2395
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0742 0.0729
Trypanosoma brucei unspecified product 0.0021 0.0108 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0068 0.0203
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0108 0.0093
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.1088 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0113 0.0379
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0057
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0291 0.3398 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.082 0.2432
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.007 0.0698 0.0684
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0287
Echinococcus granulosus peregrin 0.0031 0.0232 0.0217
Schistosoma mansoni hypothetical protein 0.0033 0.0252 0.0238
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0046 0.0406 0.0939
Echinococcus granulosus Chromobox protein 3 0.0014 0.0017 0.0002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0108 0.0093
Echinococcus granulosus chromobox protein 1 0.0084 0.0874 0.0861
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0221 0.2545 0.2534
Onchocerca volvulus 0.0037 0.03 0.2655
Schistosoma mansoni hypothetical protein 0.0033 0.0252 0.0238
Mycobacterium tuberculosis Conserved protein 0.0043 0.0379 0.0858
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.082 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0256 0.0945
Schistosoma mansoni chromobox protein 0.0084 0.0874 0.0861
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0017 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0379 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0291 0.3398 1
Mycobacterium ulcerans hypothetical protein 0.0046 0.0406 0.0905
Loa Loa (eye worm) hypothetical protein 0.0071 0.072 0.2128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0198 0.0716
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1099
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0108 0.036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0068 0.0203
Loa Loa (eye worm) hypothetical protein 0.0033 0.0246 0.0698
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.1088 0.4235
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0379 0.1431
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0291 0.3398 1
Echinococcus multilocularis lamin 0.0033 0.0246 0.0232
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0017 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0379 0.0365
Loa Loa (eye worm) hypothetical protein 0.0021 0.0108 0.0281
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0246 0.0698
Trichomonas vaginalis esterase, putative 0.0043 0.0379 0.1431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0252 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0462 0.1762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0113 0.0379
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0103 0.0267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0406 0.0939
Schistosoma mansoni hypothetical protein 0.0033 0.0252 0.0238
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.1088 0.402
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.005
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0221 0.2545 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.1088 0.402
Entamoeba histolytica CAAX amino terminal protease family 0.0046 0.0406 0.1537
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0381 0.0367
Schistosoma mansoni lamin 0.0033 0.0246 0.0232
Loa Loa (eye worm) beta-lactamase 0.0043 0.0379 0.1099
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0291 0.3398 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0155 0.1735 0.5191
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0198 0.037
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0155 0.1735 0.1722
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0291 0.3398 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0198 0.0553
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.082 0.3149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1099
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.1088 0.402
Onchocerca volvulus 0.0033 0.0246 0.2155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0742 0.1929
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0061 0.0175
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0232 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Echinococcus multilocularis cpg binding protein 0.0037 0.0296 0.0281
Loa Loa (eye worm) hypothetical protein 0.007 0.0698 0.2061
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0467 0.1782
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0113 0.0379
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0232 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0379 0.1431
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3233 0.9501
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0379 0.1112
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0418 0.1217
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Schistosoma mansoni cpg binding protein 0.0037 0.0296 0.0281
Echinococcus granulosus intermediate filament protein 0.0033 0.0246 0.0232
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0874 0.2594
Echinococcus multilocularis GPCR, family 2 0.0033 0.0252 0.0238
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0379 0.0858
Loa Loa (eye worm) hypothetical protein 0.0021 0.011 0.0287
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0559 0.1642
Echinococcus granulosus chromobox protein 2 0.0014 0.0017 0.0002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.011 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0252 0.0717
Schistosoma mansoni hypothetical protein 0.0058 0.0559 0.0545
Brugia malayi hypothetical protein 0.0014 0.0017 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0198 0.0553
Plasmodium falciparum protease, putative 0.0046 0.0406 0.1194
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0272 0.0776
Echinococcus multilocularis chromobox protein 1 0.0084 0.0874 0.0861
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0113 0.0379
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0379 0.0824
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0232 0.2957
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.1088 0.3239
Mycobacterium ulcerans hypothetical protein 0.0043 0.0379 0.0824
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3328 0.3318
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0742 0.1959
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0221 0.2545 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.082 0.3178
Schistosoma mansoni cpg binding protein 0.0035 0.0272 0.0257
Onchocerca volvulus 0.0029 0.0198 0.1708
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.082 0.2923
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.1088 0.1075
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0017 0.0002
Schistosoma mansoni hypothetical protein 0.0033 0.0252 0.0238
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0221 0.2545 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0312 0.0298
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0108 0.0093
Brugia malayi chromobox protein homolog 3 0.0047 0.0424 0.1235
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0411 0.0397
Mycobacterium ulcerans hypothetical protein 0.0046 0.0406 0.0905
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0379 0.0565
Trypanosoma brucei CAAX amino terminal protease, putative 0.0221 0.2545 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0108 0.036
Toxoplasma gondii hypothetical protein 0.0046 0.0406 0.5356
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0232 0.0217
Loa Loa (eye worm) hypothetical protein 0.0047 0.0424 0.1235
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0046 0.0406 0.0939
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0198 0.0553
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0198 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0256 0.0945
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0017 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0379 0.1431
Toxoplasma gondii hypothetical protein 0.0046 0.0406 0.5356
Onchocerca volvulus 0.0033 0.0246 0.2155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.1099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0379 0.0365
Echinococcus multilocularis lamin dm0 0.0033 0.0246 0.0232
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.082 0.0807
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.082 0.2432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0007
Echinococcus granulosus dna polymerase eta 0.0021 0.0108 0.0093
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0113 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.1088 0.1075
Brugia malayi hypothetical protein 0.0286 0.3328 1
Echinococcus multilocularis geminin 0.0205 0.2342 0.2331
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0639 0.1883
Schistosoma mansoni chromobox protein 0.0084 0.0874 0.0861
Schistosoma mansoni hypothetical protein 0.0031 0.0232 0.0217
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0336 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1123 0.3345
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0017 0.005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0467 0.4219
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0252 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0379 0.1112
Chlamydia trachomatis hypothetical protein 0.0046 0.0406 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0418 0.0404
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0198 0.0716
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0252 0.0238
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0252 0.0717
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0198 0.0274
Brugia malayi SET domain containing protein 0.0015 0.0026 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0108 0.0281
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0742 0.2604
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0379 0.0824
Onchocerca volvulus 0.0043 0.0379 0.3394
Loa Loa (eye worm) hypothetical protein 0.0037 0.03 0.086
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0198 0.0274
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.1088 0.1075
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.007 0.0698 0.0684
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0844 0.083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.1101 0.1088
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.072 0.2128
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0874 0.339
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1123 0.3345
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0379 0.0858
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1123 0.3345
Giardia lamblia PHD finger protein 15 0.0031 0.0232 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.1088 0.4235
Brugia malayi jmjC domain containing protein 0.004 0.0336 0.097
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0742 0.0729
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0198 0.0274
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0246 0.0698
Onchocerca volvulus 0.0015 0.0026 0.0107
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0379 0.0858
Schistosoma mansoni hypothetical protein 0.0205 0.2342 0.2331
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0198 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0108 0.0319
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0041 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.011 0.0006
Brugia malayi Heterochromatin protein 1 0.0084 0.0874 0.2594
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.0676
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0057
Loa Loa (eye worm) hypothetical protein 0.007 0.0698 0.2061
Brugia malayi intermediate filament protein 0.0033 0.0246 0.0698
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0252 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.082 0.2923
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0113 0.0379
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0424 0.3812
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0017 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0424 0.1609
Schistosoma mansoni chromobox protein 0.0014 0.0017 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0252 0.0238

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 1.603 uM PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] ChEMBL. No reference
AC50 (binding) = 12.84 uM PUBCHEM_BIOASSAY: Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] ChEMBL. No reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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