Detailed information for compound 789461

Basic information

Technical information
  • TDR Targets ID: 789461
  • Name: N-(4-fluorophenyl)-4-(4,4,6-trimethyl-2-sulfa nylidene-1,3-diazinan-1-yl)butanamide
  • MW: 337.455 | Formula: C17H24FN3OS
  • H donors: 1 H acceptors: 1 LogP: 2.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)(C)N=C(N1CCCC(=O)Nc1ccc(cc1)F)S
  • InChi: 1S/C17H24FN3OS/c1-12-11-17(2,3)20-16(23)21(12)10-4-5-15(22)19-14-8-6-13(18)7-9-14/h6-9,12H,4-5,10-11H2,1-3H3,(H,19,22)(H,20,23)
  • InChiKey: ONAMTNXCHHBGRJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluorophenyl)-4-(4,4,6-trimethyl-2-thioxo-hexahydropyrimidin-1-yl)butanamide
  • N-(4-fluorophenyl)-4-(4,4,6-trimethyl-2-thioxo-1-hexahydropyrimidinyl)butanamide
  • N-(4-fluorophenyl)-4-(4,4,6-trimethyl-2-thioxo-hexahydropyrimidin-1-yl)butyramide
  • MLS000729570
  • N-(4-fluorophenyl)-4-(4,4,6-trimethyl-2-thioxotetrahydropyrimidin-1(2H)-yl)butanamide
  • SMR000307847
  • EU-0020797

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0109 0.0398
Trichomonas vaginalis alpha-glucosidase, putative 0.0169 0.0702 0.2568
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0075 0.0255 0.276
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0151 0.1634
Mycobacterium tuberculosis Probable dehydrogenase 0.0491 0.2234 0.8956
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0008 0.0091
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0038 0.0079 0.0859
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0075 0.0255 0.3256
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0098 0.0366 0.5218
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0583 0.2667 0.2667
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0075 0.0255 0.276
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.0549
Mycobacterium ulcerans aldehyde dehydrogenase 0.0144 0.0586 0.748
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0107 0.0107
Echinococcus granulosus lysosomal alpha glucosidase 0.0761 0.3514 0.3514
Onchocerca volvulus Huntingtin homolog 0.0137 0.0549 0.2564
Brugia malayi Importin beta-1 subunit 0.0199 0.0846 0.1793
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0546 0.2494 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0008 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0008 0.0091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0109 0.1178
Brugia malayi glutathione reductase 0.0215 0.0923 0.1956
Trypanosoma brucei PAB1-binding protein , putative 0.0086 0.0309 0.3341
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0297 0.3219
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0144 0.0586 0.0586
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0121 0.0477 0.1788
Loa Loa (eye worm) inositol-1 0.0044 0.0109 0.0109
Trichomonas vaginalis set domain proteins, putative 0.0254 0.1108 0.4051
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0144 0.0586 0.748
Brugia malayi TAR-binding protein 0.0075 0.0258 0.0546
Echinococcus granulosus jumonji domain containing 1A 0.0074 0.0249 0.0249
Brugia malayi jmjC domain containing protein 0.0074 0.0249 0.0529
Entamoeba histolytica hypothetical protein 0.0043 0.0107 0.152
Echinococcus granulosus expressed protein 0.003 0.0041 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0961 0.0961
Echinococcus multilocularis peptidase Clp (S14 family) 0.0122 0.0479 0.0479
Schistosoma mansoni hypothetical protein 0.1151 0.5368 0.5368
Schistosoma mansoni DNA polymerase eta 0.0053 0.0151 0.0151
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0075 0.0255 0.276
Schistosoma mansoni importin beta-1 0.0199 0.0846 0.0846
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0089 0.0324 0.0324
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0122 0.0479 0.1784
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0063 0.0199 0.2155
Schistosoma mansoni hypothetical protein 0.2127 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.0258 0.0546
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0121 0.0477 0.5165
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0258 0.0258
Echinococcus granulosus GTP binding nuclear protein Ran 0.0121 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0098 0.0366 0.0366
Entamoeba histolytica Ran family GTPase 0.0121 0.0477 0.6792
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0064 0.0204 0.2214
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0109 0.0408
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0084 0.0297 0.0297
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0257 0.2787
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0008 0.0107
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0053 0.0197
Toxoplasma gondii ABC1 family protein 0.0084 0.0297 0.1114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0162 0.0668 0.2441
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0063 0.0199 0.0756
Plasmodium vivax JmjC domain containing protein 0.0074 0.0249 0.2702
Toxoplasma gondii aldehyde dehydrogenase 0.0144 0.0586 0.2196
Echinococcus granulosus zinc finger protein 0.0023 0.0011 0.0011
Mycobacterium ulcerans beta-lactamase 0.0084 0.0297 0.3796
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0008 0.0119
Brugia malayi jmjC domain containing protein 0.0276 0.121 0.2563
Trichomonas vaginalis alpha-glucosidase, putative 0.0063 0.0199 0.0728
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0109 0.1178
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0297 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Trichomonas vaginalis alpha-glucosidase, putative 0.0063 0.0199 0.0728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Brugia malayi Glycosyl hydrolases family 31 protein 0.0063 0.0199 0.0422
Echinococcus multilocularis importin 5 0.0038 0.0079 0.0079
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0078 0.0273 0.0578
Treponema pallidum bacterioferrin (TpF1) 0.003 0.0041 0.0527
Plasmodium falciparum JmjC domain-containing protein, putative 0.0074 0.0249 0.2702
Echinococcus granulosus peptidase Clp S14 family 0.0122 0.0479 0.0479
Mycobacterium tuberculosis Probable reductase 0.0491 0.2234 0.8956
Loa Loa (eye worm) hypothetical protein 0.0199 0.0846 0.0846
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0084 0.0297 0.1191
Onchocerca volvulus 0.0254 0.1108 0.5446
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0084 0.0297 0.3796
Leishmania major importin beta-1 subunit, putative 0.0162 0.0668 0.7229
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0162 0.0668 0.2441
Trichomonas vaginalis glucosylceramidase, putative 0.0597 0.2735 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0249 0.0249
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0087 0.0349
Echinococcus multilocularis tar DNA binding protein 0.0075 0.0258 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0053 0.0053
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0078 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0086 0.0309 0.0309
Mycobacterium tuberculosis Probable lipase LipE 0.0084 0.0297 0.1191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0237 0.0237
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0109 0.1549
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0075 0.0255 0.054
Plasmodium vivax SET domain protein, putative 0.0032 0.0053 0.0569
Toxoplasma gondii NADPH-glutathione reductase 0.0075 0.0255 0.0956
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0078 0.0273 0.0273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0144 0.0586 0.0586
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0122 0.0479 0.192
Toxoplasma gondii LsmAD domain-containing protein 0.0086 0.0309 0.1157
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0008 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0008 0.0091
Schistosoma mansoni inositol monophosphatase 0.0044 0.0109 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0413 0.186 0.6802
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0546 0.2494 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0144 0.0586 0.2348
Loa Loa (eye worm) hypothetical protein 0.0048 0.013 0.013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0583 0.2667 0.2667
Toxoplasma gondii thioredoxin reductase 0.0215 0.0923 0.3462
Schistosoma mansoni aldehyde dehydrogenase 0.0144 0.0586 0.0586
Brugia malayi Inositol-1 0.0044 0.0109 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0297 0.3219
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0084 0.0297 0.0297
Echinococcus granulosus neutral alpha glucosidase AB 0.0169 0.0702 0.0702
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0008 0.0008
Echinococcus granulosus muscleblind protein 0.1015 0.472 0.472
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0089 0.0324 0.0324
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0257 0.2787
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0038 0.0079 0.0859
Echinococcus multilocularis expressed protein 0.003 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0084 0.0297 0.0297
Brugia malayi hypothetical protein 0.0055 0.0164 0.0347
Loa Loa (eye worm) hypothetical protein 0.0389 0.1745 0.1745
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0008 0.0008
Echinococcus multilocularis transportin 1 0.0038 0.0079 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0086 0.0309 0.3341
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0491 0.2234 0.8938
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Mycobacterium ulcerans bacterioferritin BfrA 0.003 0.0041 0.0527
Brugia malayi Thioredoxin reductase 0.0215 0.0923 0.1956
Onchocerca volvulus 0.044 0.199 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0278 0.122 0.122
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0109 0.0398
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0084 0.0297 0.1191
Trypanosoma cruzi hypothetical protein, conserved 0.0169 0.0702 0.7604
Trichomonas vaginalis ran, putative 0.0121 0.0477 0.1744
Plasmodium falciparum glutathione reductase 0.0075 0.0255 0.276
Echinococcus granulosus lysine specific demethylase 5A 0.0278 0.122 0.122
Loa Loa (eye worm) thioredoxin reductase 0.0215 0.0923 0.0923
Trichomonas vaginalis glucosylceramidase, putative 0.0413 0.186 0.6802
Schistosoma mansoni ferritin 0.003 0.0041 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0181 0.196
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0075 0.0255 0.276
Trichomonas vaginalis glucosylceramidase, putative 0.0597 0.2735 1
Brugia malayi beta-lactamase 0.0084 0.0297 0.063
Trichomonas vaginalis glucosylceramidase, putative 0.0597 0.2735 1
Echinococcus multilocularis jumonji domain containing 1A 0.0074 0.0249 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0076 0.0287
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0169 0.0702 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0169 0.0702 0.2568
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Leishmania major alpha glucosidase II subunit, putative 0.0169 0.0702 0.7604
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0008 0.0008
Echinococcus granulosus geminin 0.1151 0.5368 0.5368
Loa Loa (eye worm) hypothetical protein 0.1015 0.472 0.472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0157 0.0648 0.0648
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0151 0.032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0278 0.122 0.122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0297 0.0297
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0008 0.0008
Trichomonas vaginalis importin beta-1, putative 0.0162 0.0668 0.2441
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0075 0.0255 0.276
Brugia malayi beta-lactamase family protein 0.0084 0.0297 0.063
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0008 0.0018
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.003 0.0041 0.0165
Echinococcus multilocularis ferritin 0.003 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0169 0.0702 0.7604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0157 0.0648 0.0648
Schistosoma mansoni protein phosphatase 2C 0.0074 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0084 0.0297 0.0297
Leishmania major cathepsin L-like protease 0.0075 0.0257 0.2787
Loa Loa (eye worm) TAR-binding protein 0.0075 0.0258 0.0258
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0076 0.026 0.026
Trichomonas vaginalis alpha-glucosidase, putative 0.0169 0.0702 0.2568
Echinococcus granulosus importin subunit beta 1 0.0199 0.0846 0.0846
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.003 0.0041 0.0527
Loa Loa (eye worm) hypothetical protein 0.0053 0.0151 0.0151
Mycobacterium tuberculosis Probable oxidoreductase 0.0546 0.2494 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 1
Mycobacterium tuberculosis Probable lipase LipD 0.0084 0.0297 0.1191
Trichomonas vaginalis alpha-glucosidase, putative 0.0063 0.0199 0.0728
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0078 0.0273 0.0273
Plasmodium falciparum thioredoxin reductase 0.0215 0.0923 1
Treponema pallidum NADH oxidase 0.0075 0.0255 0.3256
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0074 0.0249 0.2702
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0186 0.0783 0.2935
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0109 0.0109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0047 0.0047
Schistosoma mansoni ran 0.0121 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0084 0.0297 0.0297
Plasmodium falciparum ataxin-2 like protein, putative 0.0086 0.0309 0.3341
Echinococcus granulosus lysine specific demethylase 6a 0.0074 0.0249 0.0249
Loa Loa (eye worm) beta-lactamase 0.0084 0.0297 0.0297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0107 0.0107
Entamoeba histolytica hypothetical protein 0.0043 0.0107 0.152
Echinococcus granulosus thioredoxin glutathione reductase 0.0215 0.0923 0.0923
Brugia malayi jmjC domain containing protein 0.0074 0.0249 0.0529
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0103 0.0103
Schistosoma mansoni apoferritin-2 0.003 0.0041 0.0041
Giardia lamblia NADH oxidase lateral transfer candidate 0.0075 0.0255 0.5344
Loa Loa (eye worm) hypothetical protein 0.0052 0.0149 0.0149
Plasmodium falciparum transportin 0.0038 0.0079 0.0859
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0121 0.0477 0.5165
Plasmodium vivax importin-beta 2, putative 0.0199 0.0846 0.9167
Echinococcus granulosus transportin 1 0.0038 0.0079 0.0079
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0089 0.0324 0.0324
Loa Loa (eye worm) glutathione reductase 0.0215 0.0923 0.0923
Echinococcus granulosus phd:f box containing protein 0.0074 0.0249 0.0249
Mycobacterium leprae conserved hypothetical protein 0.0084 0.0297 0.1043
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0258 0.0258
Echinococcus multilocularis geminin 0.1151 0.5368 0.5368
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0089 0.0324 0.0324
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0075 0.0255 0.276
Mycobacterium tuberculosis Probable esterase LipL 0.0084 0.0297 0.1191
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0292 0.0292
Toxoplasma gondii melibiase subfamily protein 0.0583 0.2667 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Leishmania major hypothetical protein, conserved 0.0074 0.0249 0.2702
Trichomonas vaginalis alpha-glucosidase, putative 0.0169 0.0702 0.2568
Schistosoma mansoni zinc finger protein 0.0023 0.0011 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0169 0.0702 0.2568
Toxoplasma gondii Alpha-galactosidase 0.0082 0.0292 0.1095
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0075 0.0255 0.3256
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0039 0.0083 0.0083
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0186 0.0783 0.8478
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0008 0.0034
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0583 0.2667 0.2667
Toxoplasma gondii HEAT repeat-containing protein 0.0038 0.0079 0.0297
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0389 0.1745 0.1745
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0098 0.0366 0.5218
Loa Loa (eye worm) hypothetical protein 0.0063 0.0199 0.0199
Echinococcus multilocularis dna polymerase eta 0.0053 0.0151 0.0151
Leishmania major hypothetical protein, conserved 0.0084 0.0297 0.3219
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Toxoplasma gondii HEAT repeat-containing protein 0.0038 0.0079 0.0297
Echinococcus multilocularis lysosomal alpha glucosidase 0.0761 0.3514 0.3514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1834 0.8609 0.8609
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Loa Loa (eye worm) hypothetical protein 0.0084 0.0297 0.0297
Schistosoma mansoni phosphatidylserine receptor 0.0074 0.0249 0.0249
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0169 0.0702 0.2568
Leishmania major hypothetical protein, conserved 0.0086 0.0309 0.3341
Plasmodium vivax glutathione reductase, putative 0.0215 0.0923 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0055 0.0161 0.0341
Mycobacterium tuberculosis Conserved protein 0.0084 0.0297 0.1191
Schistosoma mansoni ferritin 0.003 0.0041 0.0041
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0122 0.0479 0.192
Trichomonas vaginalis ferritin, putative 0.003 0.0041 0.0151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0491 0.2234 0.8956
Schistosoma mansoni phd/f-box containing protein 0.0074 0.0249 0.0249
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0075 0.0255 0.276
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0249
Mycobacterium ulcerans hypothetical protein 0.0084 0.0297 0.3796
Echinococcus granulosus ferritin 0.003 0.0041 0.0041
Trichomonas vaginalis maltase-glucoamylase, putative 0.0063 0.0199 0.0728
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0000057452 0.0000057452
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0055 0.0161 0.0341
Schistosoma mansoni hypothetical protein 0.0043 0.0107 0.0107
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.1151 0.5368 0.5368
Schistosoma mansoni ran 0.0121 0.0477 0.0477
Echinococcus granulosus JmjC domain containing protein 4 0.0074 0.0249 0.0249
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0046 0.0117 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Mycobacterium tuberculosis Probable hydrolase 0.0084 0.0297 0.1191
Mycobacterium ulcerans esterase/lipase LipP 0.0084 0.0297 0.3796
Plasmodium falciparum ataxin-2 like protein, putative 0.0086 0.0309 0.3341
Toxoplasma gondii HEAT repeat-containing protein 0.0199 0.0846 0.3174
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0121 0.0477 0.0477
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0149 0.0149
Echinococcus multilocularis phd:f box containing protein 0.0074 0.0249 0.0249
Loa Loa (eye worm) kap beta 3 protein 0.0038 0.0079 0.0079
Brugia malayi hypothetical protein 0.0086 0.0309 0.0654
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0169 0.0702 0.2568
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0583 0.2667 0.2667
Brugia malayi hypothetical protein 0.0137 0.0549 0.1164
Echinococcus multilocularis JmjC domain containing protein 4 0.0074 0.0249 0.0249
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0063 0.0199 0.0728
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0546 0.2494 1
Brugia malayi beta-lactamase family protein 0.0084 0.0297 0.063
Echinococcus multilocularis lysine specific demethylase 6a 0.0074 0.0249 0.0249
Onchocerca volvulus Huntingtin homolog 0.0137 0.0549 0.2564
Trypanosoma cruzi importin beta-1 subunit, putative 0.0162 0.0668 0.7229
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0064 0.0204 0.2214
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0297 0.3219
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0237 0.0237
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 0.8478
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0389 0.1745 0.6382
Entamoeba histolytica HEAT repeat domain containing protein 0.0038 0.0079 0.1129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0249
Echinococcus multilocularis neutral alpha glucosidase AB 0.0169 0.0702 0.0702
Trypanosoma brucei hypothetical protein, conserved 0.0084 0.0297 0.3219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0157 0.0648 0.0648
Leishmania major hypothetical protein, conserved 0.0038 0.0079 0.0859
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0534 0.2436 0.9764
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0069 0.0226 0.2452
Trichomonas vaginalis glucosylceramidase, putative 0.0597 0.2735 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Loa Loa (eye worm) hypothetical protein 0.1015 0.472 0.472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0297 0.1087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0121 0.0477 0.5165
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0249
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0121 0.0477 0.0477
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0075 0.0255 0.276
Schistosoma mansoni inositol monophosphatase 0.0044 0.0109 0.0109
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0157 0.0648 0.1372
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Brugia malayi Muscleblind-like protein 0.1015 0.472 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.003 0.0041 0.0165
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0144 0.0586 0.6342
Onchocerca volvulus 0.0084 0.0297 0.1263
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Brugia malayi Pre-SET motif family protein 0.0223 0.0961 0.2037
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0761 0.3514 0.3514
Trichomonas vaginalis glucosylceramidase, putative 0.0597 0.2735 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0063 0.0199 0.2155
Leishmania major glycosyl hydrolase-like protein 0.0063 0.0199 0.2155
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Schistosoma mansoni aldehyde dehydrogenase 0.0144 0.0586 0.0586
Brugia malayi RNA, U transporter 1 0.0567 0.2591 0.5489
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0008 0.0034
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0028 0.0028
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0064 0.0204 0.0665
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0109 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Mycobacterium ulcerans lipase LipD 0.0084 0.0297 0.3796
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0074 0.0249 0.0935
Echinococcus multilocularis muscleblind protein 1 0.1015 0.472 0.472
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0087 0.0186
Echinococcus multilocularis translational activator gcn1 0.0038 0.0079 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0491 0.2234 0.8956
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0583 0.2667 0.2667
Schistosoma mansoni jumonji domain containing protein 0.0276 0.121 0.121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0144 0.0586 0.748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Trichomonas vaginalis alpha-glucosidase, putative 0.0169 0.0702 0.2568
Schistosoma mansoni alpha-glucosidase 0.0655 0.301 0.301
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0121 0.0477 0.101
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0257 0.2787
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0075 0.0255 0.3256
Schistosoma mansoni peptidase Clp (S14 family) 0.0186 0.0783 0.0783
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0109 0.139
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0702 0.1488
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0169 0.0702 0.2633
Brugia malayi Bromodomain containing protein 0.0089 0.0324 0.0685
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0186 0.0783 0.0783
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.2127 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0186 0.0783 0.3023
Leishmania major trypanothione reductase 0.0215 0.0923 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0008 0.0031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0297 0.0297
Plasmodium falciparum thioredoxin reductase 0.0075 0.0255 0.276
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0121 0.0477 0.5165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0186 0.0783 0.2935
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0491 0.2234 0.8956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Schistosoma mansoni hypothetical protein 0.0039 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0043 0.0107 0.152
Schistosoma mansoni apoferritin-2 0.003 0.0041 0.0041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0276 0.121 0.121
Brugia malayi kap beta 3 protein 0.0038 0.0079 0.0168
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0109 0.1178
Schistosoma mansoni hypothetical protein 0.0025 0.0017 0.0017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0064 0.0204 0.2611
Trypanosoma brucei importin beta-1 subunit, putative 0.0199 0.0846 0.9167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0258 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0297 0.1087
Leishmania major cathepsin L-like protease 0.0075 0.0257 0.2787
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Echinococcus multilocularis muscleblind protein 0.1015 0.472 0.472
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0121 0.0477 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0038 0.0079 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Loa Loa (eye worm) hypothetical protein 0.0186 0.0783 0.0783
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0107 0.0107
Echinococcus multilocularis zinc finger protein 0.0023 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Echinococcus multilocularis snurportin 1 0.2127 1 1
Trichomonas vaginalis mercuric reductase, putative 0.0075 0.0255 0.0932
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0075 0.0255 0.1022
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0583 0.2667 0.2667
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0169 0.0702 1
Trichomonas vaginalis glutathione reductase, putative 0.0075 0.0255 0.0932
Trichomonas vaginalis sucrase-isomaltase, putative 0.0169 0.0702 0.2568
Echinococcus granulosus translational activator gcn1 0.0038 0.0079 0.0079
Plasmodium falciparum importin beta, putative 0.0199 0.0846 0.9167
Echinococcus multilocularis beta LACTamase domain containing family member 0.0084 0.0297 0.0297
Echinococcus granulosus dna polymerase eta 0.0053 0.0151 0.0151
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0074 0.0249 0.2702
Leishmania major cathepsin L-like protease 0.0075 0.0257 0.2787
Leishmania major DNA polymerase eta, putative 0.0037 0.0076 0.0828
Trypanosoma brucei trypanothione reductase 0.0215 0.0923 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Mycobacterium tuberculosis Conserved protein 0.0084 0.0297 0.1191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0103 0.0103
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0074 0.0249 0.2702
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0109 0.139
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0075 0.0255 0.3256
Toxoplasma gondii hypothetical protein 0.0064 0.0204 0.0766
Trichomonas vaginalis hypothetical protein 0.0038 0.0079 0.029
Plasmodium vivax transportin, putative 0.0038 0.0079 0.0859
Schistosoma mansoni alpha glucosidase 0.0169 0.0702 0.0702
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0109 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0157 0.0648 0.0648
Echinococcus multilocularis importin subunit beta 1 0.0199 0.0846 0.0846
Brugia malayi jmjC domain containing protein 0.0074 0.0249 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Brugia malayi jmjC domain containing protein 0.0278 0.122 0.2585
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0075 0.0255 0.276
Echinococcus granulosus beta LACTamase domain containing family member 0.0084 0.0297 0.0297
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0074 0.0249 0.0249
Trichomonas vaginalis esterase, putative 0.0084 0.0297 0.1087
Schistosoma mansoni alpha-glucosidase 0.0655 0.301 0.301
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0075 0.0255 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0075 0.0255 0.0956
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0151 0.1634
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0258 0.0258
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0702 0.0702
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0075 0.0255 0.276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0149 0.0149
Onchocerca volvulus Glucosylceramidase homolog 0.0392 0.176 0.8813
Echinococcus multilocularis lysine specific demethylase 5A 0.0276 0.121 0.121
Loa Loa (eye worm) hypothetical protein 0.0084 0.0299 0.0299
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0039 0.0083 0.0083
Brugia malayi PHD-finger family protein 0.003 0.0041 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.0258 0.0258
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0249 0.0249
Leishmania major DNA polymerase eta, putative 0.0053 0.0151 0.1634
Brugia malayi RNA binding protein 0.0075 0.0258 0.0546
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.0255 0.276
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0297 0.1087
Trichomonas vaginalis alpha-glucosidase, putative 0.0063 0.0199 0.0728
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0075 0.0255 0.276
Loa Loa (eye worm) RNA binding protein 0.0075 0.0258 0.0258
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0089 0.0324 0.6803
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0076 0.0828
Trypanosoma brucei unspecified product 0.0023 0.0008 0.0091
Giardia lamblia DINP protein human, muc B family 0.0023 0.0008 0.0176
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0089 0.0324 0.0324
Echinococcus granulosus tar DNA binding protein 0.0075 0.0258 0.0258
Brugia malayi Probable ClpP-like protease 0.0186 0.0783 0.1659
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0597 0.2735 0.5794
Brugia malayi Melibiase family protein 0.0389 0.1745 0.3698
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0121 0.0477 0.5165
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0258 0.0258
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0186 0.0783 1
Plasmodium falciparum glutathione reductase 0.0215 0.0923 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0089 0.0324 0.1217
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0276 0.121 0.121
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0215 0.0923 0.3702
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0074 0.0249 0.0935
Schistosoma mansoni ferritin light chain 0.003 0.0041 0.0041
Schistosoma mansoni ferritin 0.003 0.0041 0.0041
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0075 0.0255 0.3256
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0141
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0389 0.1745 0.1745
Trypanosoma cruzi trypanothione reductase, putative 0.0215 0.0923 1
Trypanosoma brucei glucosidase, putative 0.0169 0.0702 0.7604
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0008 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.0549
Entamoeba histolytica hypothetical protein 0.0162 0.0668 0.9507
Trichomonas vaginalis glucosylceramidase, putative 0.0597 0.2735 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0086 0.0309 0.3341
Onchocerca volvulus 0.0084 0.0297 0.1263
Trypanosoma brucei importin beta-1 subunit, putative 0.0199 0.0846 0.9167
Trichomonas vaginalis alpha-glucosidase, putative 0.0063 0.0199 0.0728
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0008 0.0008
Schistosoma mansoni ferritin 0.003 0.0041 0.0041
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0583 0.2667 0.2667
Entamoeba histolytica hypothetical protein 0.0043 0.0107 0.152
Schistosoma mansoni ferritin light chain 0.003 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0089 0.0324 0.0324
Plasmodium vivax ataxin-2 like protein, putative 0.0086 0.0309 0.3341
Echinococcus granulosus importin 5 0.0038 0.0079 0.0079
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0109 0.1178
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0249 0.0249
Brugia malayi Pre-SET motif family protein 0.0032 0.0053 0.0111
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0063 0.0199 0.0728
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0084 0.0297 0.1191
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0257 0.2787
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0186 0.0783 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.0648 0.0648
Leishmania major GTP-binding protein, putative 0.0121 0.0477 0.5165
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0075 0.0255 0.276
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0028 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0075 0.0255 0.276
Brugia malayi Glycosyl hydrolases family 31 protein 0.0761 0.3514 0.7444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0157 0.0648 0.0648
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0008 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0215 0.0923 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0215 0.0923 0.0923
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0075 0.0255 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0149 0.0149
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0017 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0084 0.0297 0.063
Mycobacterium tuberculosis Conserved protein 0.0084 0.0297 0.1191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0278 0.122 0.122
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0491 0.2234 0.8956
Loa Loa (eye worm) hypothetical protein 0.0084 0.0297 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0008 0.0091
Schistosoma mansoni bromodomain containing protein 0.0075 0.0257 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0297 0.1087
Schistosoma mansoni importin-beta 2 0.0038 0.0079 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0075 0.0255 0.0255
Mycobacterium leprae Probable lipase LipE 0.0084 0.0297 0.1043
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0597 0.2735 0.2735
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0063 0.0199 0.2834
Mycobacterium ulcerans bacterioferritin BfrB 0.003 0.0041 0.0527
Onchocerca volvulus 0.0084 0.0297 0.1263
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.176 0.6436
Trypanosoma brucei glycosyl hydrolase-like protein 0.0063 0.0199 0.2155
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0076 0.026 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0257 0.2787
Brugia malayi jmjC domain containing protein 0.0074 0.0249 0.0529
Brugia malayi hypothetical protein 0.0043 0.0107 0.0226
Echinococcus multilocularis lysosomal alpha glucosidase 0.0761 0.3514 0.3514
Echinococcus granulosus dna polymerase kappa 0.0023 0.0008 0.0008
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0028 0.0028
Brugia malayi Bromodomain containing protein 0.0046 0.0116 0.0247

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 141.2538 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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