Detailed information for compound 792090

Basic information

Technical information
  • TDR Targets ID: 792090
  • Name: N-(4-bromo-2-fluorophenyl)-3,7-dimethyl-5-oxo -[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide
  • MW: 432.288 | Formula: C14H11BrFN3O3S2
  • H donors: 1 H acceptors: 3 LogP: 2.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c(c1)F)NS(=O)(=O)c1c(C)nc2n(c1=O)c(C)cs2
  • InChi: 1S/C14H11BrFN3O3S2/c1-7-6-23-14-17-8(2)12(13(20)19(7)14)24(21,22)18-11-4-3-9(15)5-10(11)16/h3-6,18H,1-2H3
  • InChiKey: WFAVHDGWWNANIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-fluoro-phenyl)-3,7-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidine-6-sulfonamide
  • N-(4-bromo-2-fluorophenyl)-3,7-dimethyl-5-oxo-6-thiazolo[3,2-a]pyrimidinesulfonamide
  • N-(4-bromo-2-fluoro-phenyl)-5-keto-3,7-dimethyl-thiazolo[3,2-a]pyrimidine-6-sulfonamide
  • N-(4-bromo-2-fluoro-phenyl)-3,7-dimethyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0062 0.0253 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0214 0.0721
Leishmania major hypothetical protein, conserved 0.0073 0.0317 0.1063
Toxoplasma gondii hypothetical protein 0.0063 0.0253 0.0985
Onchocerca volvulus 0.0032 0.0063 0.0008
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0204 0.1126 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0063 0.0253 0.0226
Loa Loa (eye worm) hypothetical protein 0.0073 0.0317 0.055
Loa Loa (eye worm) CXXC zinc finger family protein 0.0112 0.0561 0.0974
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0204 0.1126 0.3957
Loa Loa (eye worm) hypothetical protein 0.0603 0.3588 0.6226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0061 0.0105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0128 0.0217
Trichomonas vaginalis transmembrane protein nessy, putative 0.0063 0.0253 0.0872
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.063 0.5299
Brugia malayi CXXC zinc finger family protein 0.0112 0.0561 0.0878
Treponema pallidum alginate O-acetylation protein (algI) 0.0063 0.0253 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.01 0.0068
Mycobacterium ulcerans lipase LipD 0.0073 0.0317 0.2333
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0438
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0061 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0063 0.0086
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0063 0.0253 0.044
Loa Loa (eye worm) hypothetical protein 0.0442 0.2595 0.4503
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0089 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0061 0.0105
Loa Loa (eye worm) STAT protein 0.0128 0.0658 0.1142
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0063 0.0253 0.2379
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0063 0.0253 0.3342
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.099 0.0965
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0105 0.0513 0.1863
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0317 0.3168
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0062 0.0253 0.0438
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.063 0.5299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0358 0.0332
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0317 0.1114
Onchocerca volvulus Huntingtin homolog 0.0127 0.0653 0.2401
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0063 0.0253 0.0348
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0253 0.0337
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0956 0.5763 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0062 0.0253 0.0225
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0061 0.0083
Echinococcus granulosus neuropeptide receptor A26 0.0997 0.6014 0.8238
Toxoplasma gondii ABC1 family protein 0.0073 0.0317 0.1311
Mycobacterium ulcerans putative regulatory protein 0.0162 0.0865 0.753
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0743 0.2904
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0062 0.0253 0.0303
Trypanosoma cruzi glycerol uptake protein, putative 0.0063 0.0253 0.079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.099 0.1319
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0062 0.0253 0.0337
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Brugia malayi MBOAT family protein 0.0063 0.0253 0.0338
Echinococcus multilocularis neuropeptide s receptor 0.0997 0.6014 0.6003
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.2001 0.7538
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0062 0.0253 0.0786
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0063 0.0253 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.0869
Schistosoma mansoni coup transcription factor 0.0031 0.0061 0.0083
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.02 0.0173
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0141 0.074 0.0714
Loa Loa (eye worm) hypothetical protein 0.0489 0.2887 0.5009
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0253 0.0869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0061 0.0033
Leishmania major cAMP-specific phosphodiesterase, putative 0.0062 0.0253 0.0786
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0128 0.0247
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0253 0.0786
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0317 0.1114
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0063 0.0253 0.3342
Giardia lamblia Hypothetical protein 0.0062 0.0253 1
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0317 0.2333
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0071 0.004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Loa Loa (eye worm) hypothetical protein 0.008 0.0358 0.0622
Onchocerca volvulus 0.0063 0.0253 0.0781
Loa Loa (eye worm) hypothetical protein 0.0432 0.253 0.439
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1309 0.4897
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0408 0.2386 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0408 0.2386 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0408 0.2386 0.2365
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0224 0.125 0.4673
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0913 0.1584
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0062 0.0253 0.0225
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0061 0.0083
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.01 0.0072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Schistosoma mansoni hypothetical protein 0.0063 0.0253 0.0348
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0071 0.0122
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Loa Loa (eye worm) MBOAT family protein 0.0063 0.0253 0.044
Mycobacterium tuberculosis Conserved protein 0.0073 0.0317 0.0923
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0062 0.0253 0.0346
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0063 0.0253 0.0226
Loa Loa (eye worm) hypothetical protein 0.0073 0.0317 0.055
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0214 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0865 0.3205
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0913 0.0887
Trichomonas vaginalis porcupine, putative 0.0063 0.0253 0.0872
Giardia lamblia hypothetical protein 0.0062 0.0253 1
Brugia malayi Pre-SET motif family protein 0.0206 0.1136 0.1886
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.02 0.0231
Loa Loa (eye worm) hypothetical protein 0.0033 0.0071 0.0122
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.01 0.0173
Schistosoma mansoni zinc finger protein 0.0726 0.4345 0.5957
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0451 0.2647 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.1419 0.2382
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.063 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0253 0.0872
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0047 0.0064
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0317 0.3099
Loa Loa (eye worm) hypothetical protein 0.0073 0.0317 0.055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0317 0.055
Brugia malayi hypothetical protein 0.0141 0.074 0.1192
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Schistosoma mansoni alpha-glucosidase 0.0146 0.0767 0.1052
Entamoeba histolytica hypothetical protein, conserved 0.0063 0.0253 0.3342
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0071 0.0017
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0062 0.0253 0.0786
Echinococcus granulosus dnaJ subfamily B 0.1204 0.7293 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0063 0.0253 0.0348
Brugia malayi beta-lactamase family protein 0.0073 0.0317 0.0449
Schistosoma mansoni hypothetical protein 0.1204 0.7293 1
Schistosoma mansoni cpg binding protein 0.0121 0.0613 0.084
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0214 0.0618
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0317 0.0923
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0061 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.01 0.0125
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Echinococcus multilocularis survival motor neuron protein 1 0.0489 0.2887 0.2867
Mycobacterium leprae Probable lipase LipE 0.0073 0.0317 0.3099
Echinococcus granulosus zinc finger protein 0.0663 0.3959 0.5407
Schistosoma mansoni hypothetical protein 0.0141 0.074 0.1015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0016
Toxoplasma gondii hypothetical protein 0.0162 0.0865 0.4139
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0071 0.0175
Trichomonas vaginalis esterase, putative 0.0073 0.0317 0.1114
Plasmodium vivax hypothetical protein, conserved 0.0162 0.0865 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0128 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0842 0.2893
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.01 0.0285
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0063 0.0253 0.0348
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0042 0.0128 0.0249
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0214 0.0721
Brugia malayi Latrophilin receptor protein 2 0.008 0.0358 0.0522
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0063 0.0253 0.044
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0098 0.0071
Leishmania major hypothetical protein, conserved 0.0062 0.0253 0.0786
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0061 0.0038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0483 0.0742
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.063 0.2097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0061 0.0105
Schistosoma mansoni cpg binding protein 0.0121 0.0613 0.084
Entamoeba histolytica hypothetical protein 0.0141 0.074 1
Schistosoma mansoni sterol O-acyltransferase 1 0.0063 0.0253 0.0348
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0047 0.0019
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0253 0.0225
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.2368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0061 0.0105
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Plasmodium vivax phosphodiesterase gamma, putative 0.0062 0.0253 0.2368
Schistosoma mansoni alpha-glucosidase 0.0146 0.0767 0.1052
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0253 0.0786
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0061 0.0033
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0062 0.0253 0.0303
Mycobacterium tuberculosis Conserved protein 0.0073 0.0317 0.0923
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Trypanosoma cruzi glycerol uptake protein, putative 0.0063 0.0253 0.079
Echinococcus multilocularis muscleblind protein 0.0603 0.3588 0.357
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0041 0.0011
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.099 0.1358
Loa Loa (eye worm) hypothetical protein 0.0051 0.0181 0.0314
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1717 0.7111
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0726 0.4345 0.5939
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0317 0.2333
Trypanosoma brucei glycerol uptake protein, putative 0.0063 0.0253 0.079
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0913 0.1212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0061 0.0083
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0214 0.0618
Loa Loa (eye worm) hypothetical protein 0.0127 0.0653 0.1134
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0253 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0214 0.0618
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0061 0.0038
Schistosoma mansoni lipoxygenase 0.0054 0.02 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.2647 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0071 0.0052
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0071 0.0122
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0042 0.0128 0.0249
Leishmania major hypothetical protein, conserved 0.0062 0.0253 0.0786
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.029 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.0869
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0317 0.0923
Loa Loa (eye worm) MBOAT family protein 0.0063 0.0253 0.044
Leishmania major glycerol uptake protein, putative 0.0063 0.0253 0.079
Echinococcus granulosus o acyltransferase membrane bound domain 0.0063 0.0253 0.0304
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.01 0.0285
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0063 0.0253 0.0304
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Entamoeba histolytica hypothetical protein 0.0063 0.0253 0.3342
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Leishmania major glycerol uptake protein, putative 0.0063 0.0253 0.079
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0061 0.0083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.099 0.1631
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Echinococcus multilocularis pyruvate kinase 0.0033 0.0071 0.0043
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0214 0.0618
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0285
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0185 0.0493
Trypanosoma cruzi GUP1, putative 0.0063 0.0253 0.079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0061 0.0083
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0253 0.0303
Schistosoma mansoni mixed-lineage leukemia protein mll 0.024 0.1345 0.1844
Leishmania major hypothetical protein, conserved 0.0042 0.0128 0.0249
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Echinococcus multilocularis zinc finger protein 0.0027 0.0033 0.0005
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0063 0.0253 0.0226
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.0869
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0253 0.0337
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0317 0.0434
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0089 0.0061
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.01 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0063 0.0253 0.2302
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0061 0.0083
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Echinococcus granulosus cpg binding protein 0.0121 0.0613 0.0799
Loa Loa (eye worm) beta-lactamase 0.0073 0.0317 0.055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.01 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0253 0.0786
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.044
Schistosoma mansoni hypothetical protein 0.008 0.0358 0.0491
Echinococcus granulosus GPCR family 2 0.008 0.0358 0.0449
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0061 0.0033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.063 0.0603
Echinococcus granulosus o acyltransferase membrane bound domain 0.0063 0.0253 0.0304
Echinococcus multilocularis zinc finger protein 0.0663 0.3959 0.3942
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0253 0.0225
Toxoplasma gondii histone lysine methyltransferase SET1 0.0217 0.1203 0.5883
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0247 0.1389 0.5202
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus granulosus muscleblind protein 0.0603 0.3588 0.4897
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0047 0.0019
Trypanosoma cruzi GUP1, putative 0.0063 0.0253 0.079
Brugia malayi MAP kinase sur-1 0.0056 0.0214 0.0269
Echinococcus multilocularis Protein lozenge 0.0054 0.0202 0.0174
Echinococcus multilocularis dnaJ subfamily B 0.1204 0.7293 0.7285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0061 0.0105
Onchocerca volvulus 0.0073 0.0317 0.1038
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0063 0.0253 0.0226
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0358 0.0622
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0743 0.2904
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0172 0.0236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.063 0.2414
Brugia malayi MBOAT family protein 0.0063 0.0253 0.0338
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0172 0.0144
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0071 0.0175
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.01 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.099 0.1319
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0928 0.1521
Brugia malayi STAT protein, DNA binding domain containing protein 0.0128 0.0658 0.1048
Brugia malayi Bromodomain containing protein 0.0084 0.0388 0.0575
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0285
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.1419 0.2462
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.044
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0089 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0061 0.0105
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0071 0.0041
Loa Loa (eye worm) hypothetical protein 0.0403 0.2351 0.408
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.0284
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.0869
Toxoplasma gondii hypothetical protein 0.0162 0.0865 0.4139
Schistosoma mansoni pyruvate kinase 0.0033 0.0071 0.0097
Brugia malayi MBOAT family protein 0.0063 0.0253 0.0338
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0317 0.1114
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0408 0.2386 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0317 0.055
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0062 0.0253 0.0786
Loa Loa (eye worm) hypothetical protein 0.032 0.1839 0.3191
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0317 0.1063
Brugia malayi MH2 domain containing protein 0.0254 0.1431 0.2404
Loa Loa (eye worm) MBOAT family protein 0.0726 0.4345 0.7539
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0061 0.0038
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus multilocularis pyruvate kinase 0.0033 0.0071 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0317 0.0434
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0224 0.125 0.4673
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.032 0.1839 0.2522
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.044
Echinococcus multilocularis cpg binding protein 0.0121 0.0613 0.0587
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0247 0.1389 0.5202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0214 0.0721
Brugia malayi follicle stimulating hormone receptor 0.0956 0.5763 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0214 0.0721
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0063 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0253 0.0786
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0451 0.2647 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0063 0.0253 0.0348
Onchocerca volvulus 0.0073 0.0317 0.1038
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0666 0.3977 0.6868
Echinococcus granulosus pyruvate kinase 0.0033 0.0071 0.0052
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0062 0.0253 0.0786
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Mycobacterium leprae conserved hypothetical protein 0.0162 0.0865 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0063 0.0086
Onchocerca volvulus Huntingtin homolog 0.0127 0.0653 0.2401
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0726 0.4345 0.4329
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0071 0.0017
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0061 0.0033
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.229
Brugia malayi beta-lactamase 0.0073 0.0317 0.0449
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0061 0.0033
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus multilocularis sterol O acyltransferase 1 0.0063 0.0253 0.0226
Leishmania major glycerol uptake protein, putative 0.0063 0.0253 0.079
Mycobacterium ulcerans putative regulatory protein 0.0162 0.0865 0.753
Onchocerca volvulus 0.0234 0.1309 0.5056
Brugia malayi Pre-SET motif family protein 0.0032 0.0063 0.0003
Schistosoma mansoni cpg binding protein 0.0112 0.0561 0.0769
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0061 0.0038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Entamoeba histolytica hypothetical protein 0.0141 0.074 1
Mycobacterium ulcerans beta-lactamase 0.0073 0.0317 0.2333
Brugia malayi PHD-finger family protein 0.0032 0.0067 0.0011
Loa Loa (eye worm) hypothetical protein 0.0603 0.3588 0.6226
Loa Loa (eye worm) hypothetical protein 0.0073 0.0317 0.055
Brugia malayi Bromodomain containing protein 0.004 0.0113 0.0092
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0224 0.125 0.4673
Loa Loa (eye worm) hypothetical protein 0.0049 0.0172 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0172 0.0236
Loa Loa (eye worm) PDE1B protein 0.0062 0.0253 0.0438
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0047 0.0019
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0052 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0061 0.0083
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0317 0.0923
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.1389 0.5693
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.063 0.0863
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0061 0.0105
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0061 0.0033
Echinococcus granulosus tumor protein p63 0.0328 0.1891 0.256
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0408 0.2386 0.3241
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0666 0.3977 0.5433
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0317 0.1063
Loa Loa (eye worm) hypothetical protein 0.0073 0.0317 0.055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0358 0.0522
Trypanosoma brucei protein kinase, putative 0.0056 0.0214 0.0618
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0743 0.2904
Leishmania major hypothetical protein, conserved 0.0063 0.0253 0.079
Onchocerca volvulus 0.0073 0.0317 0.1038
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.1431 0.2484
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Brugia malayi hypothetical protein 0.0432 0.253 0.433
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0408 0.2386 0.9006
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0317 0.1114
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0063 0.0253 0.3342
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0403 0.2351 0.4017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0214 0.0618
Schistosoma mansoni hypothetical protein 0.0172 0.0928 0.1272
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0063 0.0253 0.0348
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0047 0.0019
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.2368
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0317 0.0923
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.2368
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0231 0.1291 0.1267
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0317 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.2001 0.7538
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0317 0.0923
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0061 0.0033
Schistosoma mansoni bromodomain containing protein 0.0072 0.0313 0.0429
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0128 0.0247
Echinococcus granulosus survival motor neuron protein 1 0.0489 0.2887 0.3931
Schistosoma mansoni survival motor neuron protein 0.01 0.0483 0.0663
Echinococcus granulosus o acyltransferase membrane bound domain 0.0063 0.0253 0.0304
Onchocerca volvulus 0.01 0.0483 0.1713
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0071 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0061 0.0038
Loa Loa (eye worm) hhat protein 0.0063 0.0253 0.044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0317 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0253 0.0786
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.099 0.1719
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Loa Loa (eye worm) hypothetical protein 0.004 0.0114 0.0197
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0071 0.004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0408 0.2386 0.9006
Schistosoma mansoni zinc finger protein 0.0027 0.0033 0.0045
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.0869
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0098 0.0066
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.063 0.5299
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0253 0.0869
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0128 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0253 0.0872
Plasmodium falciparum phosphodiesterase gamma, putative 0.0062 0.0253 0.229
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0285
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.063 0.2925
Toxoplasma gondii GAF domain-containing protein 0.0162 0.0865 0.4139
Schistosoma mansoni transcription factor LCR-F1 0.0141 0.074 0.1015
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0063 0.0253 0.0226
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0052 0.0071
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0214 0.0249
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0164 0.0225
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0071 0.004
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0062 0.0253 0.0303
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.032 0.1839 0.3119
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.2001 0.7538
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.01 0.1236
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0105 0.0513 0.1863
Mycobacterium tuberculosis Conserved protein 0.0073 0.0317 0.0923
Trypanosoma brucei glycerol uptake protein, putative 0.0063 0.0253 0.079
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0253 0.229
Echinococcus multilocularis tumor protein p63 0.0328 0.1891 0.1869
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0214 0.0249
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0061 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Entamoeba histolytica hypothetical protein 0.0141 0.074 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0358 0.0449
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0214 0.078
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.01 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.099 0.1358
Toxoplasma gondii hypothetical protein 0.0346 0.2001 1
Brugia malayi MBOAT family protein 0.0726 0.4345 0.7513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Onchocerca volvulus 0.0112 0.0561 0.2027
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0214 0.0186
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0214 0.7866
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0098 0.009
Plasmodium falciparum phosphodiesterase delta, putative 0.0062 0.0253 0.229
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0061 0.0083
Schistosoma mansoni hypothetical protein 0.008 0.0358 0.0491
Trypanosoma brucei glucosidase, putative 0.0038 0.01 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.099 0.1358
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0063 0.0253 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0061 0.0105
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0062 0.0253 0.0346
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0317 0.1063
Leishmania major mitochondrial DNA polymerase beta 0.03 0.1717 0.7111
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0062 0.0253 0.0303
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0141 0.074 0.0974
Entamoeba histolytica hypothetical protein 0.0141 0.074 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0062 0.0253 0.0337
Entamoeba histolytica vacuolar protein sorting 26 0.0063 0.0253 0.3342
Loa Loa (eye worm) runx1 0.0054 0.0202 0.035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0253 0.0786
Brugia malayi MBOAT family protein 0.0063 0.0253 0.0338
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0009 0.0016
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.0869
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0253 0.229
Echinococcus multilocularis muscleblind protein 1 0.0603 0.3588 0.357
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0231 0.1291 0.1733
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0062 0.0253 0.0786
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0061 0.0038
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0062 0.0253 0.0869
Echinococcus granulosus neuropeptide s receptor 0.0997 0.6014 0.8238
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0253 0.098
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.229
Loa Loa (eye worm) hhat protein 0.0063 0.0253 0.044
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0061 0.0038
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0063 0.0253 0.0304
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0061 0.0038
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0071 0.01
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0061 0.0038
Schistosoma mansoni hypothetical protein 0.008 0.0358 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0253 0.0872
Schistosoma mansoni alpha glucosidase 0.0038 0.01 0.0136
Echinococcus multilocularis GPCR, family 2 0.008 0.0358 0.0332
Brugia malayi Hhat protein 0.0063 0.0253 0.0338
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Mycobacterium ulcerans hypothetical protein 0.0158 0.0842 0.731
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0408 0.2386 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0062 0.0253 0.0225
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0214 0.0618
Loa Loa (eye worm) hypothetical protein 0.0074 0.0321 0.0557
Leishmania major glycerol uptake protein, putative 0.0063 0.0253 0.079
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0253 0.0303
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1136 0.1971
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0253 0.0869
Loa Loa (eye worm) hypothetical protein 0.0127 0.0653 0.1134
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0317 0.0923
Plasmodium falciparum GAF domain-related protein, putative 0.0162 0.0865 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0253 0.0346
Brugia malayi beta-lactamase family protein 0.0073 0.0317 0.0449
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0451 0.2647 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0253 0.0786
Brugia malayi hypothetical protein 0.0489 0.2887 0.4956
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0913 0.1494
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.01 0.1236
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0317 0.0391
Onchocerca volvulus 0.0048 0.0164 0.0418
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0062 0.0253 0.0786
Brugia malayi diacylglycerol acyltransferase 0.0063 0.0253 0.0338
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.2737 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0408 0.2386 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0214 0.0371
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.1431 0.2484
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0062 0.0253 0.0225
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.01 0.0092
Loa Loa (eye worm) hypothetical protein 0.0042 0.0129 0.0224
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.029 0.0263
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0062 0.0253 0.0786
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0438
Chlamydia trachomatis pyruvate kinase 0.0033 0.0071 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0317 0.0449
Loa Loa (eye worm) hypothetical protein 0.0172 0.0928 0.161
Schistosoma mansoni hypothetical protein 0.008 0.0358 0.0491
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0408 0.2386 0.3272
Loa Loa (eye worm) hypothetical protein 0.0604 0.3592 0.6233
Toxoplasma gondii hypothetical protein 0.0048 0.0166 0.0534
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0063 0.0253 0.0304
Loa Loa (eye worm) hypothetical protein 0.0432 0.253 0.439
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0063 0.0253 0.0226
Schistosoma mansoni hypothetical protein 0.01 0.0483 0.0663
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.099 0.0965
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0063 0.0253 0.0985
Echinococcus multilocularis neuropeptide receptor A26 0.0997 0.6014 0.6003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0105
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0052 0.0026
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0214 0.0186
Echinococcus granulosus sterol O acyltransferase 1 0.0063 0.0253 0.0304
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0162 0.0865 0.298
Brugia malayi Muscleblind-like protein 0.0603 0.3588 0.6186
Mycobacterium ulcerans hypothetical protein 0.0073 0.0317 0.2333
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0172 0.0192
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0913 0.0887
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0317 0.0923
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0666 0.3977 0.396
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.044
Onchocerca volvulus 0.0432 0.253 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0061 0.0083
Leishmania major glycerol uptake protein, putative 0.0063 0.0253 0.079
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.01 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0214 0.0293
Brugia malayi hypothetical protein 0.0127 0.0653 0.104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0061 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.063 0.0863
Schistosoma mansoni lozenge 0.0054 0.0202 0.0276
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.1717 0.7111
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0063 0.0253 0.0304
Trypanosoma cruzi glycerol uptake protein, putative 0.0063 0.0253 0.079
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0063 0.0253 0.0985
Schistosoma mansoni pyruvate kinase 0.0033 0.0071 0.0097
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1717 0.7111
Onchocerca volvulus 0.0098 0.0472 0.1666
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0408 0.2386 0.9006
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0042 0.0128 0.0249

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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