TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 653.729 | Formula: C38H35N7O4
H donors: 1 H acceptors: 5 LogP: 5.46 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)[C@H]1N(Cc2ccccc2)O[C@@H]2[C@H]1C(=O)OC2
InChi: 1S/C38H35N7O4/c1-2-3-13-33-39-31-19-18-27(35-34-32(23-48-38(34)47)49-45(35)22-24-9-5-4-6-10-24)20-30(31)37(46)44(33)21-25-14-16-26(17-15-25)28-11-7-8-12-29(28)36-40-42-43-41-36/h4-12,14-20,32,34-35H,2-3,13,21-23H2,1H3,(H,40,41,42,43)/t32-,34+,35+/m0/s1
InChiKey: QAJPSJBFQOHNJI-RRKBCBNCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	403 aa	18.9 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	20.4 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	381 aa	19.7 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	300 aa	28.0 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	303 aa	25.4 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	22.7 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	292 aa	25.7 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	21.8 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.8 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	23.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	23.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	20.5 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	338 aa	23.4 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	26.4 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	362 aa	24.3 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	360 aa	22.2 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	366 aa	20.8 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	24.6 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	355 aa	23.9 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	339 aa	21.2 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	319 aa	24.1 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.8 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	319 aa	24.5 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	24.9 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	26.6 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	324 aa	24.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	349 aa	25.5 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.2 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	26.6 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0065	0.0065
Toxoplasma gondii	carbamoylphosphate synthetase	0.0032	0.0368	0.5717
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0644	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0245	0.2214
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0157	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0038	0.046	0.1561
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0424	0.0424
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0303	0.09
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.018	0.2541	0.8628
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0772	0.0772
Entamoeba histolytica	hypothetical protein	0.0011	0.0065	0.0587
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0644	0.1913
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0065	0.0065
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0017	0.0017
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0028	0.0028
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0644	0.0644
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0028	0.0028
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0864	0.0864
Brugia malayi	DIX domain containing protein	0.0009	0.0028	0.0096
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0028	0.0028
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0644	0.745
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0028	0.0028
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Mycobacterium leprae	Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf	0.0247	0.3514	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0397	0.0397
Brugia malayi	Protein cec-1.	0.0011	0.0065	0.0221
Toxoplasma gondii	hypothetical protein	0.0009	0.0028	0.0437
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0457	0.0457
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0587
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0065	0.0065
Onchocerca volvulus		0.0031	0.0346	0.1029
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0245	0.0698
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0245	0.2214
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0143	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0028	0.0096
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0644	0.1913
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0065	0.0221
Brugia malayi	SET domain containing protein	0.0012	0.0081	0.0275
Trypanosoma brucei	protein kinase, putative	0.0051	0.0644	0.745
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0644	0.745
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0245	0.0833
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0319	0.0319
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0083	0.1107	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0346	0.1176
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0193
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0644	0.0644
Brugia malayi	MH2 domain containing protein	0.0119	0.1646	0.5589
Schistosoma mansoni	smad	0.0008	0.0017	0.0017
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0228	0.0228
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0011	0.0065	0.101
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0424	0.0424
Onchocerca volvulus		0.0237	0.3366	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0129	0.0438
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0028	0.0028
Plasmodium vivax	heterochromatin protein 1, putative	0.0011	0.0065	0.1766
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0122	0.1412
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.1646	0.5589
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0011	0.0065	0.101
Brugia malayi	Smad1	0.0008	0.0017	0.0058
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0585	0.0585
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0028	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0028	0.0096
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0644	0.0644
Schistosoma mansoni	microtubule-associated protein tau	0.069	1	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0047	0.0585	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.0093	0.0093
Leishmania major	hypothetical protein, conserved	0.0015	0.0122	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0245	0.0833
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0093	0.0093
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0065	0.0065
Schistosoma mansoni	dishevelled	0.0009	0.0028	0.0028
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0864	0.2936
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0193
Schistosoma mansoni	hypothetical protein	0.0015	0.0122	0.0122
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0028	0.0028
Plasmodium vivax	SET domain protein, putative	0.003	0.0335	0.9102
Brugia malayi	Bromodomain containing protein	0.0075	0.0996	0.3382
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0864	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0245	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.0032	0.0368	0.1048
Schistosoma mansoni	hypothetical protein	0.0016	0.0129	0.0129
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0397	0.1348
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.2945	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1107	0.376
Brugia malayi	chromobox protein homolog 3	0.0039	0.047	0.1595
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0513	0.1525
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0129	0.0438
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0628	0.2132
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0864	1
Schistosoma mansoni	hypothetical protein	0.0021	0.02	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Echinococcus granulosus	histone lysine methyltransferase setb	0.0047	0.0585	0.0585
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Trichomonas vaginalis	Heterochromatin protein, putative	0.0011	0.0065	0.0193
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0065	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0397	0.1348
Echinococcus multilocularis	smad	0.0008	0.0017	0.0017
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0157	0.5
Echinococcus granulosus	GPCR family 2	0.0016	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0933	0.317
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0644	0.745
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.0093	0.0316
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0065	0.0065
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0129	0.0129
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0193
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0245	0.0833
Schistosoma mansoni	hypothetical protein	0.0016	0.0129	0.0129
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0065	0.0221
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.3366	1
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0824	0.0824
Entamoeba histolytica	hypothetical protein	0.0011	0.0065	0.0587
Brugia malayi	Bromodomain containing protein	0.0038	0.0459	0.1558
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0009	0.0028	0.0096
Echinococcus multilocularis	chromobox protein 1	0.007	0.0918	0.0918
Echinococcus granulosus	smad	0.0008	0.0017	0.0017
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0245	0.0833
Echinococcus multilocularis	Smad4	0.0008	0.0017	0.0017
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0245	0.0698
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0065	0.0221
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0028	0.0028
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Onchocerca volvulus		0.0011	0.0065	0.0193
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0335	0.5203
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0028	0.0028
Brugia malayi	PHD-finger family protein	0.0025	0.0263	0.0892
Schistosoma mansoni	dishevelled	0.0009	0.0028	0.0028
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0335	0.0335
Trichomonas vaginalis	hypothetical protein	0.0011	0.0065	0.0193
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0245	0.0698
Echinococcus granulosus	chromobox protein 1	0.007	0.0918	0.0918
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0065	0.0193
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0157	0.0532
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0245	0.0698
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Schistosoma mansoni	chromobox protein	0.0011	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Brugia malayi	MH1 domain containing protein	0.0008	0.0017	0.0058
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0644	0.0644
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0143	0.0408
Entamoeba histolytica	hypothetical protein	0.0011	0.0065	0.0587
Echinococcus multilocularis	microtubule associated protein 2	0.069	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0513	0.1525
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.0093	0.0093
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0245	0.0698
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0245	0.0698
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0644	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0587
Brugia malayi	MH2 domain containing protein	0.0008	0.0017	0.0058
Schistosoma mansoni	aspartate carbamoyltransferase	0.0032	0.0368	0.0368
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0065	0.0065
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0245	0.2836
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0148	0.0148
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0028	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0157	0.0535
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0129	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0129	0.0438
Brugia malayi	Heterochromatin protein 1	0.007	0.0918	0.3117
Schistosoma mansoni	hypothetical protein	0.0016	0.0129	0.0129
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0017	0.0058
Schistosoma mansoni	zinc finger protein	0.002	0.0185	0.0185
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0644	0.745
Brugia malayi	MAP kinase sur-1	0.0051	0.0644	0.2187
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.0032	0.0368	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.02	0.068
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0017	0.0017
Brugia malayi	N-terminal motif family protein	0.018	0.2541	0.8628
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0918	0.2728
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0065	0.0065
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0143	0.0408
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0143	0.0408
Loa Loa (eye worm)	helicase	0.0011	0.0065	0.0221
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0502	0.0502
Mycobacterium ulcerans	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	0.0247	0.3514	1
Brugia malayi	hypothetical protein	0.0009	0.0028	0.0096
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0245	0.2214
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0129	0.0129
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0245	0.0698
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0245	0.0833
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0017	0.0017
Brugia malayi	Pre-SET motif family protein	0.003	0.0335	0.1138
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0148	0.0148
Onchocerca volvulus		0.0011	0.0065	0.0193
Plasmodium falciparum	heterochromatin protein 1	0.0011	0.0065	0.1766
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0065	0.1766
Brugia malayi	CHD4 protein	0.0013	0.0093	0.0316
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Onchocerca volvulus		0.0041	0.0502	0.1492
Schistosoma mansoni	hypothetical protein	0.0016	0.0129	0.0129
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0122	0.1412
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0148	0.0148
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0017	0.0058
Trypanosoma brucei	ISWI complex protein	0.0015	0.0122	0.1412
Brugia malayi	hypothetical protein	0.0011	0.0065	0.0221
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0011	0.0065	0.101
Brugia malayi	MH1 domain containing protein	0.0008	0.0017	0.0058
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0245	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0039	0.047	0.1595
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0017	0.0017
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0772	0.0772
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.047	0.1396
Echinococcus granulosus	Chromo domain	0.0011	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0028	0.0096
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0028	0.0028
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0065	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0157	0.0535
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.047	0.1396
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0245	0.0833
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Echinococcus granulosus	Smad4	0.0008	0.0017	0.0017
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0644	0.745
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0513	0.1525
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0522	0.1774
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0028	0.0096
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0644	0.2187
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.2541	0.7549
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0864	0.7808
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0028	0.0096
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0245	0.2836
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.047	0.1396
Onchocerca volvulus		0.0024	0.0245	0.0728
Echinococcus granulosus	chromobox protein 1	0.007	0.0918	0.0918
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0864	0.2936
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0585	0.1986
Leishmania major	carbamoyl-phosphate synthase, putative	0.0032	0.0368	0.4259
Schistosoma mansoni	Smad4	0.0008	0.0017	0.0017
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0245	0.0698
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0065	0.0065
Echinococcus multilocularis	Chromo domain	0.0011	0.0065	0.0065
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0587
Loa Loa (eye worm)	hypothetical protein	0.005	0.0628	0.2132
Onchocerca volvulus		0.0009	0.0028	0.0084
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0065	0.0193
Echinococcus multilocularis	zinc finger protein	0.002	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0011	0.0065	0.0065
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0157	0.4276
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0457	0.0457
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0065	0.0221
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0148	0.0148
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0644	0.0644
Schistosoma mansoni	chromobox protein	0.007	0.0918	0.0918
Echinococcus granulosus	zinc finger protein	0.002	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0157	0.0535
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0028	0.0028
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0644	0.745
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0644	0.1913
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0585	0.0585
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0028	0.0096
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0065	0.0193
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0918	0.2728
Echinococcus multilocularis	chromobox protein 1	0.007	0.0918	0.0918
Schistosoma mansoni	dep domain containing protein	0.0009	0.0028	0.0028
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0028	0.0028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0628	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0157	0.0535
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0494	0.1679
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0065	0.0193
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0065	0.1766
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0157	0.0448
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.1646	0.5589
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0157	0.4276
Schistosoma mansoni	zinc finger protein	0.0015	0.0122	0.0122
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0011	0.0065	0.1766
Brugia malayi	MH2 domain containing protein	0.0008	0.0017	0.0058
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0864	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0017	0.0017
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0644	0.1913
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0083	0.1107	1
Plasmodium falciparum	carbamoyl phosphate synthetase	0.0032	0.0368	1
Loa Loa (eye worm)	Smad1	0.0008	0.0017	0.0058
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0628	0.2132
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0303	0.09
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0918	0.3117
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0028	0.0096
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0065	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0065	0.0193
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0228	0.0228
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0129	0.0129
Schistosoma mansoni	chromobox protein	0.007	0.0918	0.0918
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0864	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0644	0.745
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0245	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0157	0.0535
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0028	0.0028
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0245	0.0698
Brugia malayi	Pre-SET motif family protein	0.0208	0.2945	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0245	0.0698
Schistosoma mansoni	chromobox protein	0.0011	0.0065	0.0065
Wolbachia endosymbiont of Brugia malayi	AICAR transformylase/IMP cyclohydrolase PurH	0.0247	0.3514	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0017	0.0017
Echinococcus granulosus	chromobox protein 2	0.0011	0.0065	0.0065
Mycobacterium tuberculosis	Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo	0.0247	0.3514	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 94 nM	In vitro binding affinity to angiotensin II receptor in bovine adrenal cortex	ChEMBL.	No reference
IC50 (binding)	= 94 nM	In vitro binding affinity to angiotensin II receptor in bovine adrenal cortex	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 79489