Detailed information for compound 823517

Basic information

Technical information
  • TDR Targets ID: 823517
  • Name: 2-(4-methyl-1-oxo-[1]benzothiolo[2,3-d]pyrida zin-2-yl)-N-[(4-propan-2-yloxyphenyl)methyl]a cetamide
  • MW: 421.512 | Formula: C23H23N3O3S
  • H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1nc(C)c2c(c1=O)c1ccccc1s2)NCc1ccc(cc1)OC(C)C
  • InChi: 1S/C23H23N3O3S/c1-14(2)29-17-10-8-16(9-11-17)12-24-20(27)13-26-23(28)21-18-6-4-5-7-19(18)30-22(21)15(3)25-26/h4-11,14H,12-13H2,1-3H3,(H,24,27)
  • InChiKey: VRHQVLNXNYIAJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-isopropoxyphenyl)methyl]-2-(4-methyl-1-oxo-benzothiopheno[2,3-d]pyridazin-2-yl)acetamide
  • N-[(4-isopropoxyphenyl)methyl]-2-(4-methyl-1-oxo-2-benzothiopheno[2,3-d]pyridazinyl)acetamide
  • N-(4-isopropoxybenzyl)-2-(1-keto-4-methyl-benzothiopheno[2,3-d]pyridazin-2-yl)acetamide
  • 2-(4-methyl-1-oxo-[1]benzothiolo[2,3-d]pyridazin-2-yl)-N-[(4-propan-2-yloxyphenyl)methyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0004
Brugia malayi Ets-domain containing protein 0.0058 0.016 0.0157
Trypanosoma brucei hexokinase 0.0143 0.05 0.1766
Brugia malayi Thioredoxin reductase 0.0115 0.0389 0.0387
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.0088 0.0212
Entamoeba histolytica serine/threonine protein kinase, putative 0.0169 0.0607 0.7017
Loa Loa (eye worm) hypothetical protein 0.0369 0.1407 0.1405
Schistosoma mansoni pyruvate kinase 0.0027 0.0035 0.0035
Treponema pallidum fructose-bisphosphate aldolase 0.0234 0.0864 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0153 0.0542 0.0542
Brugia malayi PHD-finger family protein 0.0052 0.0137 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.002 0.0006 0.0009
Brugia malayi polk-prov protein 0.0021 0.0014 0.0012
Loa Loa (eye worm) hexokinase 0.0143 0.05 0.0498
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0262 0.098 0.8927
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0088 0.0212
Plasmodium vivax hypothetical protein, conserved 0.002 0.001 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Echinococcus granulosus citrate lyase subunit beta protein 0.002 0.0006 0.0006
Onchocerca volvulus 0.0189 0.0686 0.0683
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.002 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0127 0.1439
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0087
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0102 0.0099
Entamoeba histolytica fatty acid elongase, putative 0.0132 0.0457 0.5282
Brugia malayi glucose-6-phosphate dehydrogenase 0.0075 0.0226 0.0224
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0088 0.0212
Echinococcus multilocularis hexokinase 0.0143 0.05 0.05
Trypanosoma brucei DNA polymerase eta, putative 0.0115 0.0388 0.1368
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0189 0.0686 0.794
Brugia malayi Associated with TFs and helicases family protein 0.002 0.001 0.0007
Trypanosoma brucei polo-like protein kinase 0.0169 0.0607 0.2143
Loa Loa (eye worm) hypothetical protein 0.0097 0.0318 0.0316
Onchocerca volvulus 0.0143 0.05 0.0497
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0004 0.0001
Toxoplasma gondii pyruvate kinase PyK1 0.0027 0.0035 0.0642
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Trypanosoma brucei hexokinase, putative 0.0143 0.05 0.1766
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0069 0.0205 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Loa Loa (eye worm) hexokinase 0.0044 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0001
Brugia malayi Importin beta-1 subunit 0.0023 0.002 0.0018
Echinococcus multilocularis transcription factor Dp 1 0.0031 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0102 0.0336 0.0334
Leishmania major DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.002 0.001 0.001
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0139 0.0484
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.0286 0.0284
Plasmodium vivax thioredoxin reductase, putative 0.0115 0.0389 0.0965
Echinococcus granulosus SAM and MBT domain containing protein 0.0038 0.0081 0.0081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0041 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0009 0.0015
Trypanosoma brucei hexokinase 0.0143 0.05 0.1766
Echinococcus granulosus GPCR family 2 0.0028 0.0041 0.0041
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Brugia malayi Bromodomain containing protein 0.0054 0.0145 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0069 0.0205 0.0205
Schistosoma mansoni DNA polymerase IV / kappa 0.0021 0.0014 0.0014
Schistosoma mansoni ets-related 0.0176 0.0632 0.0632
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0014 0.004
Schistosoma mansoni hypothetical protein 0.0028 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0069 0.0205 0.2356
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Trypanosoma cruzi trypanothione reductase, putative 0.0115 0.0389 0.137
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0088 0.0212
Echinococcus granulosus pyruvate kinase 0.0027 0.0035 0.0035
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2513 1 1
Leishmania major pyruvate kinase 0.0027 0.0035 0.0113
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0088 0.0088
Mycobacterium tuberculosis Conserved protein 0.002 0.0006 0.0009
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0088 0.0986
Onchocerca volvulus 0.0143 0.05 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0209 0.2391
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0043 0.0102 0.0099
Brugia malayi Pyruvate kinase, muscle isozyme 0.0027 0.0035 0.0032
Echinococcus multilocularis importin subunit beta 1 0.0023 0.002 0.002
Plasmodium falciparum glutathione reductase 0.004 0.0088 0.0212
Echinococcus multilocularis hexokinase 0.0143 0.05 0.05
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Echinococcus multilocularis L aminoadipate semialdehyde 0.0066 0.0194 0.0194
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0262 0.098 0.2441
Trypanosoma brucei unspecified product 0.0048 0.0119 0.0413
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.0173 0.017
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0049 0.0123 0.03
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0088 0.1706
Onchocerca volvulus 0.0055 0.0148 0.0144
Onchocerca volvulus 0.009 0.0287 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0027 0.0035 0.0292
Brugia malayi Pre-SET motif family protein 0.0024 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0169 0.0607 0.2143
Brugia malayi Hexokinase family protein 0.009 0.0287 0.0285
Mycobacterium tuberculosis Conserved hypothetical protein 0.0069 0.0205 0.0506
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0088 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0023 0.0023
Echinococcus multilocularis chromobox protein 1 0.0125 0.0429 0.0429
Echinococcus multilocularis histone acetyltransferase MYST2 0.0043 0.0102 0.0102
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0014 0.0226
Giardia lamblia Fructose-bisphosphate aldolase 0.0234 0.0864 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0173 0.0171
Loa Loa (eye worm) glutathione reductase 0.0115 0.0389 0.0387
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0088 0.0301
Plasmodium falciparum thioredoxin reductase 0.004 0.0088 0.0212
Plasmodium vivax hypothetical protein, conserved 0.002 0.001 0.0018
Entamoeba histolytica fatty acid elongase, putative 0.0132 0.0457 0.5282
Schistosoma mansoni importin beta-1 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0722 0.2822 0.282
Trypanosoma brucei C-8 sterol isomerase, putative 0.0722 0.2822 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.0286 0.0284
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0169 0.0607 0.0605
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0264 0.3034
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.001 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0088 0.0301
Trypanosoma cruzi DNA polymerase eta, putative 0.0115 0.0388 0.1368
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0171 0.0614 0.0614
Plasmodium vivax SET domain protein, putative 0.0024 0.0023 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0081 0.0253 0.2907
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0035 0.0031
Leishmania major hexokinase, putative 0.0143 0.05 0.1766
Mycobacterium ulcerans hypothetical protein 0.002 0.0006 0.0009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0292 0.1097 0.2734
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1017 0.4006 1
Brugia malayi mbt repeat family protein 0.0038 0.0081 0.0078
Loa Loa (eye worm) CHromoDomain protein family member 0.0022 0.0016 0.0014
Trypanosoma brucei trypanothione reductase 0.0115 0.0389 0.137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0023 0.0416
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0022 0.0016 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0004 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Echinococcus multilocularis pyruvate kinase 0.0027 0.0035 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Echinococcus multilocularis neuropeptide s receptor 0.0369 0.1409 0.1409
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0014 0.004
Echinococcus multilocularis SAM and MBT domain containing protein 0.0038 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0055 0.0148 0.0146
Plasmodium falciparum glutathione reductase 0.0115 0.0389 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0119 0.0413
Echinococcus granulosus hexokinase 0.0143 0.05 0.05
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0262 0.098 0.2441
Loa Loa (eye worm) hypothetical protein 0.0354 0.1346 0.1344
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0026 0.0031 0.0072
Echinococcus multilocularis pyruvate kinase 0.0021 0.0012 0.0012
Echinococcus multilocularis snurportin 1 0.0246 0.0914 0.0914
Echinococcus granulosus neuropeptide receptor A26 0.0369 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0075 0.0226 0.0794
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0041 0.0041
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1017 0.4006 1
Echinococcus granulosus chromobox protein 2 0.002 0.001 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0088 0.0212
Schistosoma mansoni DNA polymerase eta 0.0115 0.0388 0.0388
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0075 0.0226 0.0226
Plasmodium vivax importin-beta 2, putative 0.0023 0.002 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0014 0.004
Entamoeba histolytica hexokinase 2 0.0143 0.05 0.5781
Schistosoma mansoni hypothetical protein 0.0304 0.1146 0.1146
Loa Loa (eye worm) MBCTL1 0.0043 0.0102 0.0099
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0022 0.0016 0.0016
Echinococcus granulosus pyruvate kinase 0.0027 0.0035 0.0035
Echinococcus granulosus transcription factor Dp 1 0.0031 0.005 0.005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Loa Loa (eye worm) hexokinase type II 0.0143 0.05 0.0498
Schistosoma mansoni hypothetical protein 0.0061 0.0173 0.0173
Loa Loa (eye worm) PHD-finger family protein 0.0052 0.0137 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0004 0.0003
Entamoeba histolytica hypothetical protein 0.002 0.001 0.0087
Onchocerca volvulus 0.0066 0.0194 0.019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0088 0.0301
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.002 0.0062
Giardia lamblia Kinase, PLK 0.0169 0.0607 0.6976
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0041 0.0041
Echinococcus granulosus hexokinase type 2 0.0143 0.05 0.05
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0139 0.0484
Echinococcus granulosus chromobox protein 1 0.0125 0.0429 0.0429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0102 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0035 0.0032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0169 0.0607 0.0607
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0041 0.0041
Plasmodium falciparum pyruvate kinase 0.0027 0.0035 0.008
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0009 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0004 0.0003
Brugia malayi hexokinase 0.0143 0.05 0.0498
Leishmania major DNA polymerase kappa, putative 0.0021 0.0014 0.004
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0075 0.0226 0.0794
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1017 0.4006 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0088 0.1706
Onchocerca volvulus 0.0354 0.1346 0.1343
Echinococcus multilocularis thioredoxin glutathione reductase 0.0115 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0235 0.0869 0.0869
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.002 0.0006 0.0009
Entamoeba histolytica fatty acid elongase, putative 0.0132 0.0457 0.5282
Plasmodium vivax glutathione reductase, putative 0.0115 0.0389 0.0965
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.002 0.001 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0004 0.001
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0006 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0078 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Schistosoma mansoni hypothetical protein 0.0028 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Onchocerca volvulus Heterochromatin protein 1 homolog 0.007 0.0209 0.0205
Brugia malayi hypothetical protein 0.0354 0.1346 0.1344
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0429 0.4946
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0002 0.0002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.002 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0014 0.004
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0209 0.2391
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0066 0.0194 0.0194
Brugia malayi Fli-1 protein 0.0176 0.0632 0.063
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0081 0.0253 0.0625
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0004 0.0016
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1017 0.4006 1
Schistosoma mansoni chromobox protein 0.0125 0.0429 0.0429
Echinococcus multilocularis citrate lyase subunit beta protein 0.002 0.0006 0.0006
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1017 0.4006 1
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0264 0.3034
Onchocerca volvulus 0.004 0.0086 0.0082
Mycobacterium ulcerans hypothetical protein 0.0021 0.0014 0.0028
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0188 0.0188
Echinococcus multilocularis Chromobox protein 3 0.002 0.001 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0088 0.0212
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0069 0.0205 0.0506
Loa Loa (eye worm) runx1 0.0044 0.0106 0.0103
Echinococcus multilocularis neuropeptide receptor A26 0.0369 0.1409 0.1409
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0075 0.0226 0.0224
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1017 0.4006 1
Echinococcus multilocularis polycomb protein SCMH1 0.0038 0.0081 0.0081
Schistosoma mansoni pyruvate kinase 0.0027 0.0035 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0188 0.0188
Trypanosoma brucei chrX additional, unordered contigs 0.0021 0.0014 0.004
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.0388 0.0386
Onchocerca volvulus 0.0038 0.0081 0.0077
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0038 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0246 0.0914 0.0914
Echinococcus granulosus geminin 0.0304 0.1146 0.1146
Schistosoma mansoni myelin transcription factor 1 myt1 0.0043 0.0102 0.0102
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0087
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1017 0.4006 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.004 0.0088 0.0212
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0014 0.004
Brugia malayi PHD-finger family protein 0.002 0.0008 0.0005
Brugia malayi Pyruvate kinase, M2 isozyme 0.0027 0.0035 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0166 0.0594 0.0592
Brugia malayi CHD4 protein 0.0022 0.0016 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0088 0.0301
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0004 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0551 0.2138 0.2138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Brugia malayi Valyl-tRNA synthetase 0.002 0.001 0.0007
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0088 0.0867
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0004 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Brugia malayi Protein cec-1. 0.002 0.001 0.0007
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0081 0.0253 0.2813
Schistosoma mansoni hypothetical protein 0.0028 0.0041 0.0041
Echinococcus multilocularis GA binding protein alpha chain 0.0058 0.016 0.016
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0114 0.0385 0.3494
Entamoeba histolytica fatty acid elongase, putative 0.0132 0.0457 0.5282
Loa Loa (eye worm) hypothetical protein 0.009 0.0287 0.0285
Trichomonas vaginalis chromobox protein, putative 0.0075 0.023 0.2638
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0197 0.0689
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0093 0.0302 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Onchocerca volvulus 0.002 0.001 0.0006
Brugia malayi jmjC domain containing protein 0.0171 0.0614 0.0612
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0081 0.0081
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0052 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0035 0.0371
Leishmania major phosphopantetheinyl transferase-like protein 0.0019 0.0003 0.0000029788
Trichomonas vaginalis chromobox protein, putative 0.002 0.001 0.0082
Echinococcus multilocularis dna polymerase kappa 0.0069 0.0205 0.0205
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0035 0.0113
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0067 0.0197 0.3905
Leishmania major hypothetical protein, conserved 0.017 0.0609 0.2151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2513 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0188 0.0185
Leishmania major hypothetical protein, conserved 0.002 0.0009 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Leishmania major DNA polymerase eta, putative 0.0067 0.0197 0.0689
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0075 0.0226 0.0794
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0001
Echinococcus multilocularis dna polymerase eta 0.0115 0.0388 0.0388
Echinococcus multilocularis hexokinase type 2 0.0143 0.05 0.05
Brugia malayi chromobox protein homolog 3 0.007 0.0209 0.0206
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.002 0.001 0.0142
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.0088 0.0212
Brugia malayi Type III restriction enzyme, res subunit family protein 0.002 0.001 0.0007
Toxoplasma gondii thioredoxin reductase 0.0115 0.0389 0.7759
Trypanosoma brucei pyruvate kinase 1 0.0027 0.0035 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0035 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Echinococcus multilocularis chromobox protein 1 0.0125 0.0429 0.0429
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0139 0.0484
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.002 0.0006 0.0013
Leishmania major hexokinase, putative 0.0143 0.05 0.1766
Leishmania major DNA polymerase eta, putative 0.0115 0.0388 0.1368
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0022 0.0016 0.0016
Trypanosoma cruzi hexokinase, putative 0.0143 0.05 0.1766
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Mycobacterium ulcerans pyruvate kinase 0.0027 0.0035 0.008
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0137 0.0337
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0171 0.0614 0.0614
Echinococcus granulosus thioredoxin glutathione reductase 0.0115 0.0391 0.0391
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.0286 0.0284
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0648 0.2525 0.2525
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Loa Loa (eye worm) hypothetical protein 0.0066 0.0194 0.0192
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0004 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0262 0.098 0.2441
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.002 0.0006 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0066 0.0194 0.0192
Echinococcus multilocularis vesicular acetylcholine transporter 0.2513 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Echinococcus granulosus jumonji domain containing protein 0.0073 0.0219 0.0219
Plasmodium falciparum phd finger protein, putative 0.0052 0.0137 0.0337
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0262 0.098 0.2441
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0069 0.0205 0.0205
Brugia malayi hypothetical protein 0.0392 0.1498 0.1496
Mycobacterium tuberculosis Probable oxidoreductase 0.0292 0.1097 0.2734
Echinococcus multilocularis Protein lozenge 0.0044 0.0106 0.0106
Brugia malayi hypothetical protein 0.002 0.001 0.0007
Onchocerca volvulus 0.0392 0.1498 0.1495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0102 0.0336 0.0334
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0027 0.0035 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0004 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0004 0.0001
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0053 0.0139 0.1589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0058 0.016 0.0157
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0181 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0404 0.0401
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0088 0.0088
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0043 0.0102 0.0102
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0004 0.0003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0169 0.0607 0.0607
Plasmodium vivax DNA repair protein REV1, putative 0.0021 0.0014 0.0028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0048 0.0119 0.0119
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0088 0.0301
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0069 0.0205 0.2352
Toxoplasma gondii HEAT repeat-containing protein 0.0023 0.002 0.0351
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0009 0.0015
Trypanosoma cruzi polo-like protein kinase, putative 0.0169 0.0607 0.2143
Loa Loa (eye worm) hypothetical protein 0.0052 0.0137 0.0135
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0069 0.0205 0.0205
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0053 0.0139 0.0484
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0035 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.002 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0119 0.0413
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0115 0.0389 0.0965
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.017 0.0609 0.2151
Echinococcus granulosus GA binding protein alpha chain 0.0058 0.016 0.016
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.002 0.001 0.0018
Echinococcus multilocularis pyruvate kinase 0.0027 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0127 0.1439
Schistosoma mansoni kinase 0.0086 0.0273 0.0273
Brugia malayi hexokinase type II 0.0045 0.011 0.0107
Plasmodium falciparum thioredoxin reductase 0.0115 0.0389 0.0965
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0043 0.0043
Loa Loa (eye worm) thioredoxin reductase 0.0115 0.0389 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0078 0.0078
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0024 0.0024 0.0075
Echinococcus granulosus hexokinase 0.0143 0.05 0.05
Trichomonas vaginalis hypothetical protein 0.002 0.001 0.0082
Trypanosoma cruzi hexokinase, putative 0.0143 0.05 0.1766
Entamoeba histolytica hypothetical protein 0.002 0.001 0.0087
Echinococcus granulosus hexokinase 0.0143 0.05 0.05
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0246 0.0914 0.0912
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0075 0.0226 0.0559
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0292 0.1097 0.2734
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0041 0.0039
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.002 0.001 0.001
Loa Loa (eye worm) heterochromatin protein 1 0.0125 0.0429 0.0426
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0292 0.1097 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0088 0.0212
Echinococcus granulosus polycomb protein SCMH1 0.0038 0.0081 0.0081
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0045 0.0043
Treponema pallidum NADH oxidase 0.004 0.0088 0.0986
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.0361 0.0358
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0053 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.007 0.0209 0.0206
Trypanosoma brucei unspecified product 0.0048 0.0119 0.0413
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0004 0.0003
Onchocerca volvulus Hexokinase homolog 0.009 0.0287 0.0283
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0014 0.004
Trichomonas vaginalis chromobox protein, putative 0.0075 0.023 0.2638
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0722 0.2822 1
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0473 0.0473
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0081 0.0253 0.2907
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0088 0.0085
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0081 0.0253 0.0625
Loa Loa (eye worm) hypothetical protein 0.0392 0.1498 0.1496
Giardia lamblia PHD finger protein 15 0.0052 0.0137 0.1453
Brugia malayi Pre-SET motif family protein 0.0166 0.0594 0.0592
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0234 0.0864 1
Onchocerca volvulus 0.0044 0.0105 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0004 0.0001
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0081 0.0253 0.2907
Loa Loa (eye worm) hypothetical protein 0.0089 0.0286 0.0284
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0035 0.0031
Brugia malayi SET domain containing protein 0.0021 0.0013 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0004 0.001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0088 0.0088
Schistosoma mansoni vesicular acetylcholine transporter 0.2513 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0004 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0105 0.0105
Leishmania major trypanothione reductase 0.0115 0.0389 0.137
Leishmania major DNA damage repair protein, putative 0.0021 0.0014 0.004
Echinococcus multilocularis geminin 0.0304 0.1146 0.1146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0081 0.0081
Toxoplasma gondii hexokinase 0.0143 0.05 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.0108
Onchocerca volvulus Alhambra homolog 0.0052 0.0137 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Plasmodium falciparum DNA repair protein REV1, putative 0.0021 0.0014 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.0205 0.0203
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0048
Brugia malayi Hexokinase family protein 0.0044 0.0105 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0169 0.0607 0.7016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0081 0.0253 0.503
Schistosoma mansoni lozenge 0.0044 0.0106 0.0106
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0124
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0069 0.0205 0.0203
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0404 0.0401
Mycobacterium tuberculosis Probable reductase 0.0262 0.098 0.2441
Brugia malayi jmjC domain containing protein 0.0065 0.0188 0.0185
Echinococcus multilocularis Chromo domain 0.002 0.001 0.001
Schistosoma mansoni cellular tumor antigen P53 0.004 0.0086 0.0086
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0088 0.0986
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0429 0.4946
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0088 0.0301
Toxoplasma gondii PHD-finger domain-containing protein 0.0052 0.0137 0.2706
Plasmodium falciparum importin beta, putative 0.0023 0.002 0.0044
Echinococcus multilocularis chromobox protein 2 0.002 0.001 0.001
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0034 0.0064 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0205 0.0719
Leishmania major pyruvate kinase 0.0027 0.0035 0.0113
Loa Loa (eye worm) fli-1 protein 0.0176 0.0632 0.063
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0205 0.0719
Loa Loa (eye worm) mbt repeat family protein 0.0038 0.0081 0.0078
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0114 0.0385 0.0955
Brugia malayi glutathione reductase 0.0115 0.0389 0.0387
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Entamoeba histolytica fatty acid elongase, putative 0.0132 0.0457 0.5282
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0012
Giardia lamblia DINP protein human, muc B family 0.0069 0.0205 0.2251
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0069 0.0205 0.0719
Giardia lamblia Pyruvate kinase 0.0027 0.0035 0.0244
Loa Loa (eye worm) hexokinase 0.0143 0.05 0.0498
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0009 0.0117
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0038 0.0081 0.0077
Brugia malayi mbt repeat family protein 0.0038 0.0081 0.0078
Echinococcus granulosus importin subunit beta 1 0.0023 0.002 0.002
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0041 0.0039
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.002 0.0006 0.0013
Toxoplasma gondii PHD-finger domain-containing protein 0.0052 0.0137 0.2706
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0023 0.0023
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0114 0.0385 0.0955
Echinococcus multilocularis hexokinase 0.0143 0.05 0.05
Trypanosoma brucei unspecified product 0.0069 0.0205 0.0719
Entamoeba histolytica hexokinase 1 0.0143 0.05 0.5781
Echinococcus multilocularis peregrin 0.0054 0.0145 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0088 0.0301
Echinococcus multilocularis GPCR, family 2 0.0028 0.0041 0.0041
Echinococcus granulosus vesicular acetylcholine transporter 0.2513 1 1
Schistosoma mansoni hypothetical protein 0.0052 0.0137 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0607 0.0607
Echinococcus multilocularis jumonji domain containing protein 0.0073 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.002 0.0006 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0188 0.0188
Schistosoma mansoni hexokinase 0.0143 0.05 0.05
Trichomonas vaginalis chromobox protein, putative 0.002 0.001 0.0082
Echinococcus granulosus Chromo domain 0.002 0.001 0.001
Echinococcus multilocularis tumor protein p63 0.027 0.101 0.101
Echinococcus granulosus L aminoadipate semialdehyde 0.0066 0.0194 0.0194
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0035 0.0113
Brugia malayi Bromodomain containing protein 0.006 0.0168 0.0166
Plasmodium vivax pyruvate kinase, putative 0.0027 0.0035 0.008
Mycobacterium tuberculosis Probable dehydrogenase 0.0262 0.098 0.2441
Mycobacterium ulcerans DNA polymerase IV 0.0069 0.0205 0.0506
Brugia malayi Bromodomain containing protein 0.0031 0.005 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0004 0.0003
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0014 0.004
Entamoeba histolytica hypothetical protein 0.002 0.001 0.0087
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0088 0.0212
Schistosoma mansoni chromobox protein 0.002 0.001 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0088 0.0301
Onchocerca volvulus 0.0143 0.05 0.0497
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0048 0.0119 0.0119
Brugia malayi Hexokinase family protein 0.0143 0.05 0.0498
Echinococcus granulosus dna polymerase eta 0.0115 0.0388 0.0388
Trypanosoma brucei hypothetical protein, conserved 0.017 0.0609 0.2151
Schistosoma mansoni microtubule-associated protein tau 0.0551 0.2138 0.2138
Brugia malayi serine/threonine-protein kinase plk-2 0.0169 0.0607 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Trypanosoma brucei pyruvate kinase 1, putative 0.0027 0.0035 0.0113
Trichomonas vaginalis Heterochromatin protein, putative 0.002 0.001 0.0082
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.002 0.002
Echinococcus granulosus chromobox protein 1 0.0125 0.0429 0.0429
Brugia malayi MH2 domain containing protein 0.0119 0.0404 0.0401
Plasmodium vivax heterochromatin protein 1, putative 0.002 0.001 0.0018
Loa Loa (eye worm) hexokinase 0.009 0.0287 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0014 0.004
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0153 0.0542 0.0542
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0075 0.0226 0.0226
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0002 0.0002
Leishmania major C-8 sterol isomerase-like protein 0.0722 0.2822 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Echinococcus granulosus Chromobox protein 3 0.002 0.001 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0075 0.023 0.0226
Mycobacterium ulcerans hypothetical protein 0.0019 0.0004 0.0003
Echinococcus granulosus PHD finger protein rhinoceros 0.0052 0.0137 0.0137
Echinococcus granulosus dna polymerase kappa 0.0069 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Plasmodium falciparum heterochromatin protein 1 0.002 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0057 0.0154 0.0152
Echinococcus granulosus snurportin 1 0.0246 0.0914 0.0914
Echinococcus granulosus peregrin 0.0054 0.0145 0.0145
Schistosoma mansoni gabp alpha 0.0058 0.016 0.016
Brugia malayi Ets-domain containing protein 0.0058 0.016 0.0157
Trichomonas vaginalis DNA polymerase eta, putative 0.0069 0.0205 0.2352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0234 0.0864 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0043 0.0102 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0014 0.004
Echinococcus granulosus tumor protein p63 0.027 0.101 0.101
Brugia malayi M-phase phosphoprotein, mpp8 0.002 0.001 0.0007
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0053 0.0139 0.0139
Brugia malayi hypothetical protein 0.002 0.0009 0.0006
Chlamydia trachomatis oxoacyl-ACP synthase III 0.1017 0.4006 1
Treponema pallidum hexokinase (hxk) 0.0143 0.05 0.5779
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0025 0.0027 0.0085
Echinococcus multilocularis PHD finger protein rhinoceros 0.0052 0.0137 0.0137
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0009 0.0021
Schistosoma mansoni hypothetical protein 0.0304 0.1146 0.1146
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0088 0.0301
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0169 0.0607 0.2143
Brugia malayi RNA, U transporter 1 0.0066 0.019 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0078 0.0078
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0053 0.0139 0.0137
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.001 0.0018
Schistosoma mansoni chromobox protein 0.002 0.001 0.001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0053 0.0139 0.0137
Echinococcus multilocularis microtubule associated protein 2 0.0551 0.2138 0.2138
Mycobacterium ulcerans DNA polymerase IV 0.0069 0.0205 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0014 0.004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0234 0.0864 1
Echinococcus granulosus neuropeptide s receptor 0.0369 0.1409 0.1409
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0053 0.0139 0.0139
Brugia malayi Heterochromatin protein 1 0.0125 0.0429 0.0426
Trichomonas vaginalis chromobox protein, putative 0.002 0.001 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.0205 0.0719
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.002 0.001 0.0142
Trichomonas vaginalis Citrate lyase beta chain, putative 0.002 0.0006 0.0042
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0049 0.0123 0.2414
Loa Loa (eye worm) hypothetical protein 0.0354 0.1346 0.1344
Schistosoma mansoni hypothetical protein 0.002 0.001 0.001
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0035 0.0032
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0075 0.0226 0.0559
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0075 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0084
Plasmodium vivax hexokinase, putative 0.0143 0.05 0.1243
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0009 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Schistosoma mansoni chromobox protein 0.0125 0.0429 0.0429
Schistosoma mansoni bromodomain containing protein 0.0051 0.013 0.013
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0722 0.2822 0.282
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0041 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0119 0.0413
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.017 0.0609 0.2151
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0007
Echinococcus granulosus histone acetyltransferase MYST2 0.0043 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0028 0.0041 0.0041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0169 0.0607 0.0603
Loa Loa (eye worm) hypothetical protein 0.0115 0.0388 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Mycobacterium ulcerans hypothetical protein 0.002 0.0006 0.0009
Loa Loa (eye worm) helicase 0.002 0.001 0.0007
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0075 0.0226 0.2598
Onchocerca volvulus 0.002 0.001 0.0006
Plasmodium falciparum hexokinase 0.0143 0.05 0.1243
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0035 0.0371
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0004 0.0004
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0014 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0078 0.0078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0102 0.0336 0.0336
Chlamydia trachomatis pyruvate kinase 0.0027 0.0035 0.008
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0088 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0205 0.0719
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0004 0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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