Detailed information for compound 839447

Basic information

Technical information
  • TDR Targets ID: 839447
  • Name: 7-bromo-2-methyl-4-phenylpyrido[1,2-a]pyrimid in-5-ium
  • MW: 300.173 | Formula: C15H12BrN2+
  • H donors: 0 H acceptors: 1 LogP: 4.84 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2[n+](c1)c(cc(n2)C)c1ccccc1
  • InChi: 1S/C15H12BrN2/c1-11-9-14(12-5-3-2-4-6-12)18-10-13(16)7-8-15(18)17-11/h2-10H,1H3/q+1
  • InChiKey: JMVDJYTZJTYIDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-bromo-2-methyl-4-phenyl-pyrido[1,2-a]pyrimidin-5-ium
  • CBMicro_021343
  • ZINC00435480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0039 0.0439 0.0439
Onchocerca volvulus 0.0073 0.1052 0.2671
Onchocerca volvulus 0.004 0.0448 0.1137
Loa Loa (eye worm) hypothetical protein 0.0056 0.0744 0.1384
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1052 0.3752
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0973 0.2057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0276 0.109
Brugia malayi prolyl oligopeptidase family protein 0.0168 0.2786 0.5891
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0179 0.7076
Echinococcus multilocularis nmda type glutamate receptor 0.014 0.2268 0.2268
Echinococcus granulosus snurportin 1 0.031 0.5371 0.5371
Brugia malayi Cytochrome P450 family protein 0.0016 0.001 0.0022
Schistosoma mansoni hypothetical protein 0.0147 0.2412 0.3098
Echinococcus granulosus metabotropic glutamate receptor 5 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.01 0.1554 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.473 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.4361 0.922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2298 0.2298
Echinococcus granulosus tar DNA binding protein 0.0069 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1959
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.1192 0.1192
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1959
Toxoplasma gondii ABC1 family protein 0.0073 0.1052 0.4161
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0091 0.0192
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0179 0.064
Brugia malayi beta-lactamase family protein 0.0073 0.1052 0.2225
Brugia malayi beta-lactamase 0.0073 0.1052 0.2225
Echinococcus multilocularis NAD(P) binding domain 0.0154 0.2529 0.2529
Schistosoma mansoni ran 0.0021 0.0114 0.0146
Entamoeba histolytica hypothetical protein 0.0039 0.0434 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.0091 0.0091
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.3427 0.638
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1965 0.3658
Brugia malayi hypothetical protein 0.0025 0.0179 0.0379
Schistosoma mansoni glutamate receptor NMDA 0.027 0.4646 0.5966
Trichomonas vaginalis ran, putative 0.0021 0.0114 0.0241
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.4361 0.8121
Onchocerca volvulus 0.0049 0.062 0.1573
Onchocerca volvulus 0.0073 0.1052 0.2671
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.0091 0.0091
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0595 0.1257
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0056 0.0754 0.0754
Schistosoma mansoni bromodomain containing protein 0.0069 0.0973 0.125
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0906 0.0906
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1052 0.4363
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.0406
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.473 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.4361 0.922
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.062 0.0796
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0209 0.0209
Echinococcus granulosus metabotropic glutamate receptor 2 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.1192 0.2219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1052 0.1351
Plasmodium falciparum importin beta, putative 0.0029 0.0254 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1052 0.2225
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0973 0.0973
Echinococcus granulosus nmda type glutamate receptor 0.002 0.0091 0.0091
Toxoplasma gondii 6,7-dihydropteridine reductase 0.0154 0.2529 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2298 0.2298
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0153 0.0324
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.0091 0.0091
Onchocerca volvulus 0.0048 0.0595 0.151
Schistosoma mansoni importin beta-1 0.0029 0.0254 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1823 0.7207
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0434 0.0557
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0153 0.0324
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.002 0.0091 0.0169
Schistosoma mansoni hypothetical protein 0.008 0.1192 0.153
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.002 0.0091 0.0169
Schistosoma mansoni tyrosine kinase 0.002 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0042
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0744 0.1572
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0056 0.0104
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0399 0.0399
Echinococcus granulosus glutamate receptor subunit protein glur 0.0039 0.0439 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2298 0.2951
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1052 0.1351
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0039 0.0439 0.0439
Schistosoma mansoni ran 0.0021 0.0114 0.0146
Leishmania major hypothetical protein, conserved 0.0073 0.1052 0.3752
Schistosoma mansoni dihydropteridine reductase 0.0154 0.2529 0.3248
Loa Loa (eye worm) hypothetical protein 0.0042 0.0489 0.091
Mycobacterium ulcerans beta-lactamase 0.0073 0.1052 0.4363
Echinococcus granulosus glutamate NMDA receptor subunit 0.027 0.4646 0.4646
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0399 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2298 0.2951
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.3009 0.7638
Loa Loa (eye worm) hypothetical protein 0.0145 0.2375 0.4421
Mycobacterium leprae Probable lipase LipE 0.0073 0.1052 1
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0147 0.2412 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0254 0.1003
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1959
Loa Loa (eye worm) hypothetical protein 0.0048 0.0596 0.1109
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1052 0.1282
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.062 0.0796
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0179 0.7076
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1052 0.1052
Schistosoma mansoni glutamate receptor AMPA 0.0039 0.0439 0.0563
Schistosoma mansoni tyrosine kinase 0.002 0.0091 0.0116
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0015
Echinococcus granulosus NADP binding domain 0.0154 0.2529 0.2529
Schistosoma mansoni hypothetical protein 0.008 0.1192 0.153
Entamoeba histolytica Ran family GTPase 0.0021 0.0114 0.2625
Schistosoma mansoni hypothetical protein 0.0048 0.0595 0.0764
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3186 0.6735
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.01 0.1554 0.6445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0334
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0744 0.0744
Schistosoma mansoni hypothetical protein 0.0174 0.2894 0.3717
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0596 0.0765
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1052 0.2225
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1052 0.2225
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1958
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.062 0.1573
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.2894 0.6119
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1052 0.1959
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0254 0.2409
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1052 0.1282
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0179 0.1705
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1965 0.3658
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0209 0.0209
Onchocerca volvulus 0.0059 0.0798 0.2027
Mycobacterium tuberculosis Conserved protein 0.0073 0.1052 0.1282
Echinococcus granulosus nmda type glutamate receptor 0.014 0.2268 0.2268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2298 0.2298
Echinococcus granulosus muscleblind protein 0.0145 0.2375 0.2375
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0114 0.1082
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.3991 0.3991
Mycobacterium ulcerans formate hydrogenlyase HycD 0.004 0.0448 0.1858
Brugia malayi hypothetical protein 0.0234 0.3991 0.8437
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.014 0.2268 0.2268
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1052 0.2225
Schistosoma mansoni cpg binding protein 0.0059 0.0798 0.1025
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.062 0.062
Schistosoma mansoni hypothetical protein 0.031 0.5371 0.6897
Brugia malayi Metabotropic glutamate receptor precursor. 0.002 0.0091 0.0192
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0434 0.0434
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.001 0.0037
Schistosoma mansoni zinc finger protein 0.0024 0.0153 0.0197
Schistosoma mansoni hypothetical protein 0.008 0.1192 0.153
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.002 0.0091 0.0091
Mycobacterium ulcerans lipase LipD 0.0073 0.1052 0.4363
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0145 0.2375 0.4421
Plasmodium vivax importin-beta 2, putative 0.0029 0.0254 0.2409
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.1192 0.1192
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0147 0.2412 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.4361 0.8121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0906 0.0906
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0276 0.0354
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0804 0.0804
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0056 0.0754 0.2689
Echinococcus multilocularis glutamate receptor 2 0.002 0.0091 0.0091
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.001 0.0019
Brugia malayi NADH dehydrogenase subunit 1 0.004 0.0448 0.0947
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.7787 0.7787
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0179 0.064
Leishmania major cytochrome p450-like protein 0.0016 0.001 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0231 0.3935 0.8319
Entamoeba histolytica hypothetical protein 0.002 0.0091 0.2089
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Brugia malayi Importin beta-1 subunit 0.0029 0.0254 0.0536
Loa Loa (eye worm) glutamate receptor 2 0.0039 0.0439 0.0816
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0254 0.2409
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0754 0.1594
Loa Loa (eye worm) hypothetical protein 0.0092 0.141 0.2625
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0169 0.2804 1
Brugia malayi hypothetical protein 0.002 0.0091 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2298 0.2951
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0973 0.125
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0056 0.0754 0.7166
Brugia malayi mbt repeat family protein 0.0049 0.062 0.131
Entamoeba histolytica hypothetical protein 0.0039 0.0434 1
Brugia malayi mbt repeat family protein 0.0049 0.062 0.131
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Brugia malayi CXXC zinc finger family protein 0.0059 0.0798 0.1688
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.1082
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.473 1
Echinococcus granulosus zinc finger protein 0.0024 0.0153 0.0153
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0511 0.0952
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.001 0.0043
Loa Loa (eye worm) MBCTL1 0.0056 0.0744 0.1384
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.473 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0744 0.0744
Echinococcus multilocularis glutamate receptor 2 0.0059 0.0804 0.0804
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0108 0.0228
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0045 0.0057
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0045 0.0045
Brugia malayi Bromodomain containing protein 0.0081 0.1193 0.2522
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0254 0.0254
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.01 0.1554 0.5
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0744 0.0744
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.062 0.062
Brugia malayi hypothetical protein 0.0092 0.141 0.298
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0275 0.473 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0091 0.0169
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0059 0.0804 0.0804
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.2021 0.2596
Loa Loa (eye worm) RNA binding protein 0.0069 0.0973 0.1812
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0168 0.2786 0.2786
Schistosoma mansoni hypothetical protein 0.0039 0.0439 0.0563
Schistosoma mansoni ATP-binding cassette transporter 0.0039 0.0439 0.0563
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.1192 0.2519
Onchocerca volvulus 0.002 0.0091 0.023
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0076 0.0142
Schistosoma mansoni NADH dehydrogenase subunit 1 0.004 0.0448 0.0575
Trichomonas vaginalis esterase, putative 0.0073 0.1052 0.2225
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0076
Onchocerca volvulus 0.004 0.0448 0.1137
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.8207 1
Leishmania major hypothetical protein, conserved 0.0025 0.0179 0.064
Trypanosoma brucei ISWI complex protein 0.0016 0.0012 0.0111
Loa Loa (eye worm) hypothetical protein 0.0039 0.0445 0.0828
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0804 0.0804
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0744 0.0744
Brugia malayi RNA binding protein 0.0069 0.0973 0.2057
Schistosoma mansoni hypothetical protein 0.0021 0.0112 0.0144
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1052 0.1052
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.01 0.1554 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0434 0.0434
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.004 0.0448 0.0834
Brugia malayi Glutamate receptor 1 precursor 0.0039 0.0439 0.0927
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.4492
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.0406
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0091 0.0169
Echinococcus multilocularis metabotropic glutamate receptor 2 0.002 0.0091 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0596 0.0765
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.473 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0153 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1052 0.3752
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.1154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0011 0.0011
Echinococcus granulosus glutamate receptor 2 0.0059 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1959
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 1
Loa Loa (eye worm) glutamate receptor 0.002 0.0091 0.0169
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0114 0.0114
Brugia malayi PHD-finger family protein 0.0029 0.0253 0.0535
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0596 0.0596
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0798 0.1486
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0973 0.1812
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.1192 0.1192
Brugia malayi hypothetical protein 0.0043 0.0511 0.1081
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.473 1
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0439 0.0563
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.5371 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1052 0.1282
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.3252 0.3252
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.004 0.0448 0.0546
Loa Loa (eye worm) hypothetical protein 0.0092 0.141 0.2625
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0241
Chlamydia trachomatis glutamine binding protein 0.01 0.1554 0.5
Brugia malayi Cytochrome P450 family protein 0.0026 0.0197 0.0416
Brugia malayi Guanylyl cyclase protein 23 0.002 0.0091 0.0192
Echinococcus multilocularis NMDA receptor 0.0039 0.0439 0.0439
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0056 0.0754 0.2689
Schistosoma mansoni hypothetical protein 0.0346 0.6031 0.7744
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.01 0.1554 0.1894
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0112 0.0208
Brugia malayi Pre-SET motif family protein 0.0203 0.3427 0.7244
Schistosoma mansoni eyes absent homolog 0.0092 0.141 0.1811
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0179 0.0709
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0804 0.0804
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3186 0.6735
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0973 0.125
Schistosoma mansoni glutamate receptor NMDA 0.0059 0.0804 0.1033
Mycobacterium tuberculosis Conserved protein 0.0073 0.1052 0.1282
Brugia malayi hypothetical protein 0.0016 0.0018 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.3991 0.3991
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0091 0.0192
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.0091 0.0192
Brugia malayi Muscleblind-like protein 0.0145 0.2375 0.502
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0045 0.0057
Brugia malayi Bromodomain containing protein 0.0039 0.0443 0.0937
Onchocerca volvulus 0.003 0.0276 0.07
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0091 0.0116
Echinococcus granulosus GPCR family 2 0.008 0.1192 0.1192
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Echinococcus granulosus importin subunit beta 1 0.0029 0.0254 0.0254
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1052 0.1282
Loa Loa (eye worm) glutamate receptor 1 0.0039 0.0439 0.0816
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0114 0.0114
Echinococcus multilocularis muscleblind protein 1 0.0145 0.2375 0.2375
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0056 0.0754 0.2982
Echinococcus multilocularis geminin 0.0346 0.6031 0.6031
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.027 0.4646 0.4646
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0197 0.0366
Echinococcus granulosus geminin 0.0346 0.6031 0.6031
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0233 0.0233
Brugia malayi hypothetical protein 0.0039 0.0434 0.0917
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0114 0.045
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0091 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1052 0.2225
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Schistosoma mansoni protein kinase 0.002 0.0091 0.0116
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0056 0.0754 0.2689
Leishmania major importin beta-1 subunit, putative 0.0024 0.0153 0.0547
Schistosoma mansoni hypothetical protein 0.0346 0.6031 0.7744
Plasmodium vivax SET domain protein, putative 0.003 0.0276 0.262
Trypanosoma brucei cytochrome P450, putative 0.0016 0.001 0.0099
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0039 0.0439 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0973 0.125
Brugia malayi Glutamate receptor 2 precursor 0.0039 0.0439 0.0927
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0179 0.1705
Loa Loa (eye worm) hypothetical protein 0.0174 0.2894 0.5389
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1052 1
Schistosoma mansoni hypothetical protein 0.0442 0.7787 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0153 0.0153
Brugia malayi TAR-binding protein 0.0069 0.0973 0.2057
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1959
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0011 0.0014
Brugia malayi Pre-SET motif family protein 0.003 0.0276 0.0583
Echinococcus granulosus tyrosine kinase 0.002 0.0091 0.0091
Echinococcus granulosus cpg binding protein 0.0064 0.0895 0.0895
Entamoeba histolytica hypothetical protein 0.0024 0.0153 0.3539
Loa Loa (eye worm) dihydropteridine reductase-PC 0.0154 0.2529 0.4709
Brugia malayi beta-lactamase family protein 0.0073 0.1052 0.2225
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0564 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1052 0.1959
Loa Loa (eye worm) CYP4Cod1 0.0016 0.001 0.0019
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0275 0.473 0.8807
Echinococcus multilocularis GPCR, family 2 0.008 0.1192 0.1192
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0056 0.0754 0.7166
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.2298 0.4858
Schistosoma mansoni hypothetical protein 0.0039 0.0434 0.0557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2298 0.2298
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1052 0.4363
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.001 0.0019
Onchocerca volvulus 0.002 0.0091 0.023
Echinococcus multilocularis muscleblind protein 0.0145 0.2375 0.2375
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.002 0.0091 0.023
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0039 0.0439 0.0439
Schistosoma mansoni glutamate receptor AMPA 0.0039 0.0439 0.0563
Entamoeba histolytica hypothetical protein 0.0039 0.0434 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.3252 0.3252
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0091 0.0192
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.062 0.062
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0973 0.1812
Echinococcus granulosus dnaJ subfamily B 0.0442 0.7787 0.7787
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1052 0.1282
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0064 0.0895 0.115
Mycobacterium ulcerans hypothetical protein 0.0073 0.1052 0.4363
Brugia malayi hypothetical protein 0.004 0.0448 0.0947
Loa Loa (eye worm) beta-lactamase 0.0073 0.1052 0.1959
Leishmania major extracellular receptor, putative 0.002 0.0091 0.0323
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0804 0.0804
Echinococcus multilocularis cpg binding protein 0.0064 0.0895 0.0895
Leishmania major GTP-binding protein, putative 0.0021 0.0114 0.0406
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.0804 0.0804
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.062 0.1154
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0168 0.2786 0.2786
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0011 0.0011
Echinococcus multilocularis glutamate receptor 2 0.0039 0.0439 0.0439
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.0091 0.0169
Brugia malayi Cytochrome P450 family protein 0.0016 0.001 0.0022
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0039 0.0439 0.0439
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.2298 0.4279
Echinococcus granulosus NADH dehydrogenase subunit 1 0.0147 0.2412 0.2412
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0059 0.0804 0.0804
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1052 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0056 0.0754 0.0754
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0276 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0973 0.125
Schistosoma mansoni hypothetical protein 0.0299 0.5165 0.6633
Onchocerca volvulus 0.0231 0.3939 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0168 0.2786 0.7073
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.3009 0.6361
Brugia malayi NADH dehydrogenase subunit 1, identical 0.004 0.0448 0.0947
Loa Loa (eye worm) hypothetical protein 0.0047 0.0586 0.1091
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.0804 0.0804
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0209 0.0268
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0039 0.0439 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1052 0.2225
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0439 0.0563
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0596 0.0596
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0153 0.0547
Entamoeba histolytica hypothetical protein 0.0039 0.0434 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0168 0.2786 0.3578
Mycobacterium tuberculosis Conserved protein 0.0073 0.1052 0.1282
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0744 0.0955
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0472
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0056 0.0754 0.0968
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0076
Brugia malayi RNA, U transporter 1 0.0083 0.1229 0.2597
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1052 0.1282
Schistosoma mansoni hypothetical protein 0.008 0.1192 0.153
Echinococcus multilocularis snurportin 1 0.031 0.5371 0.5371
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.1192 0.1192
Brugia malayi MH2 domain containing protein 0.0123 0.1965 0.4153
Leishmania major quinonoid dihydropteridine reductase 0.0169 0.2804 1
Echinococcus granulosus glutamate receptor 2 0.002 0.0091 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0276 0.0354
Trypanosoma cruzi extracellular receptor, putative 0.002 0.0091 0.0323
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0439 0.0563
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0045 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1052 1
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.001 0.0037
Echinococcus multilocularis tyrosine kinase 0.002 0.0091 0.0091
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0011 0.0011
Onchocerca volvulus 0.0073 0.1052 0.2671
Schistosoma mansoni survival motor neuron protein 0.0048 0.0595 0.0764
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0147 0.2412 0.2939
Loa Loa (eye worm) prolyl oligopeptidase 0.0168 0.2786 0.5188
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.062 0.062
Schistosoma mansoni cpg binding protein 0.0064 0.0895 0.115
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.1192 0.2219
Loa Loa (eye worm) hypothetical protein 0.0234 0.3991 0.7431
Brugia malayi Latrophilin receptor protein 2 0.008 0.1192 0.2519
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1052 0.1282
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0973 0.125
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.062 0.0796
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0042
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.0091 0.0091
Brugia malayi dihydropteridine reductase-like 0.0154 0.2529 0.5346

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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